keyword
https://read.qxmd.com/read/37666657/abnormal-gastrointestinal-motility-is-a-major-factor-in-explaining-symptoms-and-a-potential-therapeutic-target-in-patients-with-disorders-of-gut-brain-interaction
#21
REVIEW
Michael Camilleri
The objective of this article is to review the evidence of abnormal gastrointestinal (GI) tract motor functions in the context of disorders of gut-brain interaction (DGBI). These include abnormalities of oesophageal motility, gastric emptying, gastric accommodation, colonic transit, colonic motility, colonic volume and rectal evacuation. For each section regarding GI motor dysfunction, the article describes the preferred methods and the documented motor dysfunctions in DGBI based on those methods. The predominantly non-invasive measurements of gut motility as well as therapeutic interventions directed to abnormalities of motility suggest that such measurements are to be considered in patients with DGBI not responding to first-line approaches to behavioural or empirical dietary or pharmacological treatment...
November 24, 2023: Gut
https://read.qxmd.com/read/37638839/the-role-of-gastric-function-in-control-of-food-intake-and-body-weight-in-relation-to-obesity-as-well-as-pharmacological-and-surgical-interventions
#22
REVIEW
Michael Camilleri
PURPOSE: The objectives of this review are to summarize the role of gastric motor functions in the development of satiation (defined broadly as postprandial fullness) and satiety (reduced appetite or postponing desire to eat after a meal) and their impact on weight change. The specific topics are the methods of measurement of gastric emptying and accommodation and their impact on food intake, satiation, and satiety. A second focus contrasts bariatric surgery to endoscopic gastroplasty that alter gastric emptying and incretin responses in markedly divergent manners...
August 28, 2023: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://read.qxmd.com/read/37582318/body-appreciation-around-the-world-measurement-invariance-of-the-body-appreciation-scale-2-bas-2-across-65-nations-40-languages-gender-identities-and-age
#23
JOURNAL ARTICLE
Viren Swami, Ulrich S Tran, Stefan Stieger, Toivo Aavik, Hamed Abdollahpour Ranjbar, Sulaiman Olanrewaju Adebayo, Reza Afhami, Oli Ahmed, Annie Aimé, Marwan Akel, Hussam Al Halbusi, George Alexias, Khawla F Ali, Nursel Alp-Dal, Anas B Alsalhani, Sara Álvares-Solas, Ana Carolina Soares Amaral, Sonny Andrianto, Trefor Aspden, Marios Argyrides, John Jamir Benzon R Aruta, Stephen Atkin, Olusola Ayandele, Migle Baceviciene, Radvan Bahbouh, Andrea Ballesio, David Barron, Ashleigh Bellard, Sóley Sesselja Bender, Kerime Derya Beydağ, Gorana Birovljević, Marie-Ève Blackburn, Teresita Borja-Alvarez, Joanna Borowiec, Miroslava Bozogáňová, Solfrid Bratland-Sanda, Matthew H E M Browning, Anna Brytek-Matera, Marina Burakova, Yeliz Çakır-Koçak, Pablo Camacho, Vittorio Emanuele Camilleri, Valentina Cazzato, Silvia Cerea, Apitchaya Chaiwutikornwanich, Trawin Chaleeraktrakoon, Tim Chambers, Qing-Wei Chen, Xin Chen, Chin-Lung Chien, Phatthanakit Chobthamkit, Bovornpot Choompunuch, Emilio J Compte, Jennifer Corrigan, Getrude Cosmas, Richard G Cowden, Kamila Czepczor-Bernat, Marcin Czub, Wanderson Roberto da Silva, Mahboubeh Dadfar, Simon E Dalley, Lionel Dany, Jesus Alfonso D Datu, Pedro Henrique Berbert de Carvalho, Gabriel Lins de Holanda Coelho, Avila Odia S De Jesus, Sonia Harzallah Debbabi, Sandesh Dhakal, Francesca Di Bernardo, Donka D Dimitrova, Jacinthe Dion, Barnaby Dixson, Stacey M Donofrio, Marius Drysch, Hongfei Du, Angel M Dzhambov, Claire El-Jor, Violeta Enea, Mehmet Eskin, Farinaz Farbod, Lorleen Farrugia, Leonie Fian, Maryanne L Fisher, Michał Folwarczny, David A Frederick, Matthew Fuller-Tyszkiewicz, Adrian Furnham, Antonio Alías García, Shulamit Geller, Marta Ghisi, Alireza Ghorbani, Maria Angeles Gomez Martinez, Sarah Gradidge, Sylvie Graf, Caterina Grano, Gyöngyvér Gyene, Souheil Hallit, Motasem Hamdan, Jonathan E Handelzalts, Paul H P Hanel, Steven R Hawks, Issa Hekmati, Mai Helmy, Tetiana Hill, Farah Hina, Geraldine Holenweger, Martina Hřebíčková, Olasupo Augustine Ijabadeniyi, Asma Imam, Başak İnce, Natalia Irrazabal, Rasa Jankauskiene, Ding-Yu Jiang, Micaela Jiménez-Borja, Verónica Jiménez-Borja, Evan M Johnson, Veljko Jovanović, Marija Jović, Marko Jović, Alessandra Costa Pereira Junqueira, Lisa-Marie Kahle, Adam Kantanista, Ahmet Karakiraz, Ayşe Nur Karkin, Erich Kasten, Salam Khatib, Nuannut Khieowan, Patricia Joseph Kimong, Litza Kiropoulos, Joshua Knittel, Neena Kohli, Mirjam Koprivnik, Aituar Kospakov, Magdalena Król-Zielińska, Isabel Krug, Garry Kuan, Yee Cheng Kueh, Omar Kujan, Miljana Kukić, Sanjay Kumar, Vipul Kumar, Nishtha Lamba, Mary Anne Lauri, Maria Fernanda Laus, Liza April LeBlanc, Hyejoo J Lee, Małgorzata Lipowska, Mariusz Lipowski, Caterina Lombardo, Andrea Lukács, Christophe Maïano, Sadia Malik, Mandar Manjary, Lidia Márquez Baldó, Martha Martinez-Banfi, Karlijn Massar, Camila Matera, Olivia McAnirlin, Moisés Roberto Mebarak, Anwar Mechri, Juliana Fernandes Filgueiras Meireles, Norbert Mesko, Jacqueline Mills, Maya Miyairi, Ritu Modi, Adriana Modrzejewska, Justyna Modrzejewska, Kate E Mulgrew, Taryn A Myers, Hikari Namatame, Mohammad Zakaria Nassani, Amanda Nerini, Félix Neto, Joana Neto, Angela Noguiera Neves, Siu-Kuen Ng, Devi Nithiya, Jiaqing O, Sahar Obeid, Camila Oda-Montecinos, Peter Olamakinde Olapegba, Tosin Tunrayo Olonisakin, Salma Samir Omar, Brynja Örlygsdóttir, Emrah Özsoy, Tobias Otterbring, Sabine Pahl, Maria Serena Panasiti, Yonguk Park, Muhammad Mainuddin Patwary, Tatiana Pethö, Nadezhda Petrova, Jakob Pietschnig, Sadaf Pourmahmoud, Vishnunarayan Girishan Prabhu, Vita Poštuvan, Pavol Prokop, Virginia L Ramseyer Winter, Magdalena Razmus, Taotao Ru, Mirjana Rupar, Reza N Sahlan, Mohammad Salah Hassan, Anđela Šalov, Saphal Sapkota, Jacob Owusu Sarfo, Yoko Sawamiya, Katrin Schaefer, Michael Schulte-Mecklenbeck, Veya Seekis, Kerim Selvi, Mehdi Sharifi, Anita Shrivastava, Rumana Ferdousi Siddique, Valdimar Sigurdsson, Vineta Silkane, Ana Šimunić, Govind Singh, Alena Slezáčková, Christine Sundgot-Borgen, Gill Ten Hoor, Passagorn Tevichapong, Arun Tipandjan, Jennifer Todd, Constantinos Togas, Fernando Tonini, Juan Camilo Tovar-Castro, Lise Katrine Jepsen Trangsrud, Pankaj Tripathi, Otilia Tudorel, Tracy L Tylka, Anar Uyzbayeva, Zahir Vally, Edmunds Vanags, Luis Diego Vega, Aitor Vicente-Arruebarrena, Jose Vidal-Mollón, Roosevelt Vilar, Hyxia Villegas, Mona Vintilă, Christoph Wallner, Mathew P White, Simon Whitebridge, Sonja Windhager, Kah Yan Wong, Eric Kenson Yau, Yuko Yamamiya, Victoria Wai Lan Yeung, Marcelo Callegari Zanetti, Magdalena Zawisza, Nadine Zeeni, Martina Zvaríková, Martin Voracek
The Body Appreciation Scale-2 (BAS-2) is a widely used measure of a core facet of the positive body image construct. However, extant research concerning measurement invariance of the BAS-2 across a large number of nations remains limited. Here, we utilised the Body Image in Nature (BINS) dataset - with data collected between 2020 and 2022 - to assess measurement invariance of the BAS-2 across 65 nations, 40 languages, gender identities, and age groups. Multi-group confirmatory factor analysis indicated that full scalar invariance was upheld across all nations, languages, gender identities, and age groups, suggesting that the unidimensional BAS-2 model has widespread applicability...
August 13, 2023: Body Image
https://read.qxmd.com/read/37562453/overview-of-the-enteric-nervous-system
#24
JOURNAL ARTICLE
Gary M Mawe, Kenton M Sanders, Michael Camilleri
Propulsion of contents in the gastrointestinal tract requires coordinated functions of the extrinsic nerves to the gut from the brain and spinal cord, as well as the neuromuscular apparatus within the gut. The latter includes excitatory and inhibitory neurons, pacemaker cells such as the interstitial cells of Cajal and fibroblast-like cells, and smooth muscle cells. Coordination between these extrinsic and enteric neurons results in propulsive functions which include peristaltic reflexes, migrating motor complexes in the small intestine which serve as the housekeeper propelling to the colon the residual content after digestion, and mass movements in the colon which lead to defecation...
August 2023: Seminars in Neurology
https://read.qxmd.com/read/37536942/prolonged-febrile-illness-following-first-dose-of-chadox1
#25
JOURNAL ARTICLE
Michael Caruana Dingli, Luke Bugeja, Robert Camilleri
A woman in her 40s, with a known history of fibromyalgia, presented with high-grade fever and constitutional symptoms occurring 5 days following vaccination with Oxford-AstraZeneca COVID-19 vaccine (ChAdOx1). Her inflammatory markers and neutrophil count were found to be elevated and as such, she was started on antibiotics. Despite treatment, markers remained elevated and temperature spikes persisted for another 4 weeks before these symptoms subsided, and her blood tests normalised. All investigations taken in the interim were negative, with no source being identified for the fever...
August 3, 2023: BMJ Case Reports
https://read.qxmd.com/read/37482172/a-randomized-controlled-trial-of-efficacy-and-safety-of-cannabidiol-in-idiopathic-and-diabetic-gastroparesis
#26
JOURNAL ARTICLE
Ting Zheng, Joelle BouSaba, Ann Taylor, Saam Dilmaghani, Irene Busciglio, Paula Carlson, Monique Torres, Michael Ryks, Duane Burton, William Scott Harmsen, Michael Camilleri
BACKGROUND & AIMS: Cannabis (delta-9-tetrahydrocannabinol), a nonselective cannabinoid-receptor agonist, relieves nausea and pain. Cannabidiol (CBD), a cannabinoid receptor 2 inverse agonist with central effects, also reduces gut sensation and inflammation. We compared the effects of 4 weeks of treatment with pharmaceutical CBD vs placebo in patients with idiopathic or diabetic (diabetes mellitus) gastroparesis. METHODS: We performed a randomized, double-blinded, placebo-controlled study of CBD twice daily (Epidiolex escalated to 20 mg/kg/d; Jazz Pharmaceuticals, Dublin, Ireland) in patients with nonsurgical gastroparesis with delayed gastric emptying of solids (GES)...
July 22, 2023: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/37457592/persistent-animal-identification-leveraging-non-visual-markers
#27
JOURNAL ARTICLE
Michael P J Camilleri, Li Zhang, Rasneer S Bains, Andrew Zisserman, Christopher K I Williams
Our objective is to locate and provide a unique identifier for each mouse in a cluttered home-cage environment through time, as a precursor to automated behaviour recognition for biological research. This is a very challenging problem due to (i) the lack of distinguishing visual features for each mouse, and (ii) the close confines of the scene with constant occlusion, making standard visual tracking approaches unusable. However, a coarse estimate of each mouse's location is available from a unique RFID implant, so there is the potential to optimally combine information from (weak) tracking with coarse information on identity...
2023: Machine Vision and Applications
https://read.qxmd.com/read/37455609/focal-epidermodysplasia-verruciformis-like-pathologic-changes-in-skin-neoplasms
#28
JOURNAL ARTICLE
Nessa Aghazadeh Mohandesi, Rewan M Abdelwahab, Michael J Camilleri
No abstract text is available yet for this article.
July 17, 2023: Journal of Cutaneous Pathology
https://read.qxmd.com/read/37350432/neutrophilic-eccrine-hidradenitis-a-retrospective-study
#29
JOURNAL ARTICLE
Nasro A Isaq, Nimay Anand, Michael J Camilleri, Nessa A Mohandesi, Afsaneh Alavi
BACKGROUND: Neutrophilic eccrine hidradenitis (NEH) is a benign neutrophilic dermatosis not well recognized beyond an association with malignancy. Although the disease is commonly reported in adults with malignancy, this association is uncommon in children. The diagnosis of NEH is predominantly based on histologic findings to exclude alternative diagnoses for adults, but biopsy is not usually required for children. METHODS: A retrospective study was performed of adult and pediatric patients diagnosed with NEH at three Mayo Clinic sites from January 1, 1992, to January 1, 2022...
June 23, 2023: International Journal of Dermatology
https://read.qxmd.com/read/37333362/concerted-epithelial-and-stromal-changes-during-progression-of-barrett-s-esophagus-to-invasive-adenocarcinoma-exposed-by-multi-scale-multi-omics-analysis
#30
Michael K Strasser, David L Gibbs, Philippe Gascard, Joanna Bons, John W Hickey, Christian M Schürch, Yuqi Tan, Sarah Black, Pauline Chu, Alican Ozkan, Nathan Basisty, Veena Sangwan, Jacob Rose, Samah Shah, Sophie Camilleri-Broet, Pierre-Oliver Fiset, Nicolas Bertos, Julie Berube, Haig Djambazian, Rui Li, Spyridon Oikonomopoulos, Daffolyn Rachael Fels-Elliott, Sarah Vernovsky, Elee Shimshoni, Deborah Collyar, Ann Russell, Ioannis Ragoussis, Matthew Stachler, James R Goldenring, Stuart McDonald, Donald E Ingber, Birgit Schilling, Garry P Nolan, Thea D Tlsty, Sui Huang, Lorenzo E Ferri
Esophageal adenocarcinoma arises from Barrett's esophagus, a precancerous metaplastic replacement of squamous by columnar epithelium in response to chronic inflammation. Multi-omics profiling, integrating single-cell transcriptomics, extracellular matrix proteomics, tissue-mechanics and spatial proteomics of 64 samples from 12 patients' paths of progression from squamous epithelium through metaplasia, dysplasia to adenocarcinoma, revealed shared and patient-specific progression characteristics. The classic metaplastic replacement of epithelial cells was paralleled by metaplastic changes in stromal cells, ECM and tissue stiffness...
June 11, 2023: bioRxiv
https://read.qxmd.com/read/37196797/apposition-of-fibroblasts-with-metaplastic-gastric-cells-promotes-dysplastic-transition
#31
JOURNAL ARTICLE
Su-Hyung Lee, Ela W Contreras Panta, David Gibbs, Yoonkyung Won, Jimin Min, Changqing Zhang, Joseph T Roland, Se-Hoon Hong, Yoojin Sohn, Evan Krystofiak, Bogun Jang, Lorenzo Ferri, Veena Sangwan, Jiannis Ragoussis, Sophie Camilleri-Broët, Joseph Caruso, Chira Chen-Tanyolac, Michael Strasser, Philippe Gascard, Thea D Tlsty, Sui Huang, Eunyoung Choi, James R Goldenring
BACKGROUND & AIMS: Elements of field cancerization including atrophic gastritis, metaplasia and dysplasia promote gastric cancer development in association with chronic inflammation. However, it remains unclear how stroma changes during carcinogenesis and how the stroma contributes to progression of gastric preneoplasia. Here we investigated heterogeneity of fibroblasts, one of the most important elements in the stroma, and their roles in neoplastic transformation of metaplasia. METHODS: We utilized single cell transcriptomics to evaluate the cellular heterogeneity of mucosal cells from human gastric cancer patients...
May 15, 2023: Gastroenterology
https://read.qxmd.com/read/37164114/potential-value-of-biomarker-based-approaches-for-evaluation-and-management-of-costly-functional-gastrointestinal-diseases
#32
REVIEW
Michael Camilleri, Joelle BouSaba
No abstract text is available yet for this article.
May 8, 2023: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/37150810/histopathologic-features-predictive-of-perivascular-deposition-of-iga-on-direct-immunofluorescence-in-cases-of-leukocytoclastic-vasculitis-a-retrospective-study-of-112-specimens
#33
JOURNAL ARTICLE
Fangyi Xie, Emma F Johnson, David A Wetter, Michael J Camilleri, Austin Todd, Julia S Lehman
IgA vasculitis is a small-vessel vasculitis subtype with increased risk of systemic involvement. We aimed to investigate if any light-microscopic features can predict the presence of perivascular granular IgA deposits on direct immunofluorescence (DIF) microscopy. We performed a retrospective search of cutaneous pathology reports from our internal and consultation practice (January 1, 2010-October 5, 2021) with a diagnosis of leukocytoclastic vasculitis and accompanying DIF. A blinded dermatopathologist reviewed standard microscopy slides for predetermined histopathological features...
July 2023: Journal of Cutaneous Pathology
https://read.qxmd.com/read/37144536/bile-acid-diarrhea-as-bad-as-it-gets
#34
REVIEW
Joelle BouSaba, Michael Camilleri
PURPOSE OF REVIEW: Bile acid diarrhea (BAD) is a common but under-recognized gastrointestinal condition that manifests with increased stool frequency and urgency, and a looser stool consistency. The aim of this review is to present recent advances in the pathophysiology, mechanisms, manifestations, diagnosis, and treatment of BAD. RECENT FINDINGS: Patients with BAD have evidence of accelerated colonic transit, increased gut mucosal permeability, altered stool microbiome composition, and decreased quality of life...
May 1, 2023: Current Opinion in Gastroenterology
https://read.qxmd.com/read/37084852/effects-of-fgf19-analogue-aldafermin-in-patients-with-bile-acid-diarrhea-a-randomized-placebo-control-trial
#35
JOURNAL ARTICLE
Joelle BouSaba, Monique Torres, Saam Dilmaghani, W Scott Harmsen, Lei Ling, Michael Camilleri
No abstract text is available yet for this article.
April 20, 2023: Gastroenterology
https://read.qxmd.com/read/37007741/phenotype-tailored-lifestyle-intervention-on-weight-loss-and-cardiometabolic-risk-factors-in-adults-with-obesity-a-single-centre-non-randomised-proof-of-concept-study
#36
JOURNAL ARTICLE
Lizeth Cifuentes, Wissam Ghusn, Fauzi Feris, Alejandro Campos, Daniel Sacoto, Alan De la Rosa, Alison McRae, Thom Rieck, Sara Mansfield, Jason Ewoldt, Jamie Friend, Karen Grothe, Ryan J Lennon, Maria D Hurtado, Matthew M Clark, Michael Camilleri, Donald D Hensrud, Andres Acosta
BACKGROUND: Lifestyle interventions for weight loss are currently not individualised to underlying pathophysiology and behavioral traits in obesity. We aim to compare the outcome of a standard lifestyle intervention (SLI) to phenotype-tailored lifestyle interventions (PLI) on weight loss, cardiometabolic risk factors and physiologic variables contributing to obesity. METHODS: This 12-week, single-centre non-randomised proof-of-concept clinical trial including men and women aged 18-65 years with a body mass index (BMI) greater than 30 without history of any bariatric procedure, and current use of any medication known to affect weight...
April 2023: EClinicalMedicine
https://read.qxmd.com/read/37001737/update-on-treatment-of-abdominal-pain-in-irritable-bowel-syndrome-a-narrative-review
#37
REVIEW
Michael Camilleri, Saam Dilmaghani
The objectives of this narrative review are to update readers on the current state-of-the-art regarding diverse approaches for the treatment of pain, global symptoms, or adequate relief in irritable bowel syndrome (IBS). The article appraises medications, dietary interventions including low fermentable oligosaccharides, disaccharides, and monosaccharides and polyols (FODMAP) diet, fecal microbial transplantation (FMT), electrical approaches, and behavioral therapies including cognitive behavioral therapy (CBT), gut-directed hypnotherapy (GDH), mindfulness, and open-label placebo...
May 2023: Pharmacology & Therapeutics
https://read.qxmd.com/read/36999540/pharmacogenetic-interactions-of-medications-administered-for-weight-loss-in-adults-a-systematic-review-and-meta-analysis
#38
REVIEW
Joelle BouSaba, Kia Vosoughi, Saam Dilmaghani, Larry J Prokop, Michael Camilleri
Aim: To analyze roles of single nucleotide variants (SNVs) on weight loss with US FDA-approved medications. Materials & methods: We searched the literature up until November 2022. Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines were followed. Results: 14 studies were included in qualitative analysis and seven in meta-analysis. SNVs in CNR1 , GLP-1R , MC4R , TCF7L2 , CTRB1/2 , ADIPOQ , SORCS1 and ANKK1 were evaluated relative to weight loss with glucagon-like peptide-1 agonists (13 studies) or naltrexone-bupropion (one study)...
April 2023: Pharmacogenomics
https://read.qxmd.com/read/36968499/research-trends-in-the-field-of-the-gut-brain-interaction-functional-dyspepsia-in-the-spotlight-an-integrated-bibliometric-and-science-mapping-approach
#39
REVIEW
Tai Zhang, Beihua Zhang, Xiangxue Ma, Jiaqi Zhang, Yuchen Wei, Fengyun Wang, Xudong Tang
OBJECTIVES: This study aims to perform a bibliometric analysis of functional dyspepsia (FD), which includes visualizing bibliographic information, in order to identify prevailing study themes, topics of interest, contributing journals, countries, institutions, and authors as well as co-citation patterns. METHODS: The Web of Science™ Core Collection Database was used to retrieve all peer-reviewed scientific publications related to FD research. The validated search terms were entered into the "title" and "author keywords" fields, and the results were sorted by publication year from 2006 to 2022...
2023: Frontiers in Neuroscience
https://read.qxmd.com/read/36944480/ten-reasons-gastroenterologists-and-hepatologists-should-be-treating-obesity
#40
REVIEW
Michael Camilleri, Emad M El-Omar
No abstract text is available yet for this article.
June 2023: Gut
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