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Michael Camilleri

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https://www.readbyqxmd.com/read/29717197/effects-of-ngm282-an-fgf19-variant-on-colonic-transit-and-bowel-function-in-functional-constipation-a-randomized-phase-2-trial
#1
Ibironke Oduyebo, Michael Camilleri, Alfred D Nelson, Disha Khemani, Sara Linker Nord, Irene Busciglio, Duane Burton, Deborah Rhoten, Michael Ryks, Paula Carlson, Leslie Donato, Alan Lueke, Kathline Kim, Stephen J Rossi, Alan R Zinsmeister
OBJECTIVE: NGM282 is an analog of fibroblast growth factor 19 (FGF19), a potent inhibitor of bile acid (BA) synthesis in animals and humans. In phase 2 trials in type 2 diabetes and primary biliary cholangitis, NGM282 was associated with dose-related abdominal cramping and diarrhea. We aimed to examine effects of NGM282 on colonic transit, stool frequency and consistency, hepatic BA synthesis (fasting serum C4), fecal fat, and BA in functional constipation (FC). METHODS: Two-dose NGM282 (1 and 6 mg, subcutaneously daily), parallel-group, randomized, placebo-controlled, 14-day study in patients with FC (Rome III criteria) and baseline colonic transit 24 h geometric center (GC) <3...
May 2, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29709540/implications-of-pharmacogenomics-to-the-management-of-ibs
#2
REVIEW
Michael Camilleri
The objectives are to review the role of pharmacogenomics in drug metabolism of medications typically used in patients with irritable bowel syndrome (IBS) focusing predominantly on cytochrome P450 metabolism. Other aims are to provide examples of genetic variation of receptors or intermediary pathways that are targets for IBS drugs and to critically appraise the situations where precision medicine is impacting health in IBS. Pharmacogenomics impacts both pharmacokinetics and pharmacodynamics. Although large clinical trials have not incorporated testing for genetic variations that could impact the efficacy of medications in IBS, there are therapeutic advantages to inclusion of pharmacogenomics testing for individual patients, as has been demonstrated particularly in the treatment with central neuromodulators in psychiatry practice...
April 27, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29626450/female-specific-association-between-variants-on-chromosome-9-and-self-reported-diagnosis-of-irritable-bowel-syndrome
#3
Ferdinando Bonfiglio, Tenghao Zheng, Koldo Garcia-Etxebarria, Fatemeh Hadizadeh, Luis Bujanda, Francesca Bresso, Lars Agreus, Anna Andreasson, Aldona Dlugosz, Greger Lindberg, Peter T Schmidt, Pontus Karling, Bodil Ohlsson, Magnus Simren, Susanna Walter, Gerardo Nardone, Rosario Cuomo, Paolo Usai-Satta, Francesca Galeazzi, Matteo Neri, Piero Portincasa, Massimo Bellini, Giovanni Barbara, Anna Latiano, Matthias Hübenthal, Vincent Thijs, Mihai G Netea, Daisy Jonkers, Lin Chang, Emeran A Mayer, Mira M Wouters, Guy Boeckxstaens, Michael Camilleri, Andre Franke, Alexandra Zhernakova, Mauro D'Amato
BACKGROUND & AIMS: Genetic factors are believed to affect risk for irritable bowel syndrome (IBS), but there have been no sufficiently powered and adequately sized studies. To identify DNA variants associated with IBS risk, we performed a genome-wide association study (GWAS) of the large UK Biobank population-based cohort, which includes genotype and health data from 500,000 participants. METHODS: We studied 7,287,191 high-quality single-nucleotide polymorphisms in individuals who self-reported a doctor's diagnosis of IBS (cases; m=9576) compared to the remainder of the cohort (controls; n=336,499) (mean age of study subjects, 40-69 years)...
April 4, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29624132/collaboration-in-a-competitive-healthcare-system-negotiation-101-for-clinicians
#4
Robyn Clay-Williams, Andrew Johnson, Paul Lane, Zhicheng Li, Lauren Camilleri, Teresa Winata, Michael Klug
Purpose The purpose of this paper is to evaluate the effectiveness of negotiation training delivered to senior clinicians, managers and executives, by exploring whether staff members implemented negotiation skills in their workplace following the training, and if so, how and when. Design/methodology/approach This is a qualitative study involving face-to-face interviews with 18 senior clinicians, managers and executives who completed a two-day intensive negotiation skills training course. Interviews were transcribed verbatim, and inductive interpretive analysis techniques were used to identify common themes...
April 9, 2018: Journal of Health Organization and Management
https://www.readbyqxmd.com/read/29622808/expert-consensus-document-advances-in-the-diagnosis-and-classification-of-gastric-and-intestinal-motility-disorders
#5
REVIEW
Jutta Keller, Gabrio Bassotti, John Clarke, Phil Dinning, Mark Fox, Madhusudan Grover, Per M Hellström, Meiyun Ke, Peter Layer, Carolina Malagelada, Henry P Parkman, S Mark Scott, Jan Tack, Magnus Simren, Hans Törnblom, Michael Camilleri
Disturbances of gastric, intestinal and colonic motor and sensory functions affect a large proportion of the population worldwide, impair quality of life and cause considerable health-care costs. Assessment of gastrointestinal motility in these patients can serve to establish diagnosis and to guide therapy. Major advances in diagnostic techniques during the past 5-10 years have led to this update about indications for and selection and performance of currently available tests. As symptoms have poor concordance with gastrointestinal motor dysfunction, clinical motility testing is indicated in patients in whom there is no evidence of causative mucosal or structural diseases such as inflammatory or malignant disease...
April 6, 2018: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29582208/update-on-bile-acid-malabsorption-finally-ready-for-prime-time
#6
REVIEW
Priya Vijayvargiya, Michael Camilleri
PURPOSE OF REVIEW: To provide an update on the prevalence, pathophysiology, disease associations, and treatment options for bile acid malabsorption (BAM). RECENT FINDINGS: •Molecular mechanisms-BAs prevent water reabsorption and increase water secretion by intracellular mediators, increasing aquaporin channels and intracellular permeability. •Inflammatory bowel disease-new molecular mechanisms of BAM are identified in patients without ileal disease, including changes in expression of ileal BA transporter and nuclear receptors involved in BA homeostasis...
March 26, 2018: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/29563144/guanylate-cyclase-c-as-a-therapeutic-target-in-gastrointestinal-disorders
#7
REVIEW
Scott A Waldman, Michael Camilleri
Functional gastrointestinal disorders (FGIDs) and IBDs are two of the most prevalent disorders of the GI tract and consume a significant proportion of healthcare resources. Recent studies have shown that membrane-bound guanylate cyclase-C (GC-C) receptors lining the GI tract may serve as novel therapeutic targets in the treatment of FGIDs and IBDs. GC-C receptor activation by its endogenous paracrine hormones uroguanylin and guanylin, and the resulting intracellular production of its downstream effector cyclic GMP, occurs in a pH-dependent manner and modulates key physiological functions...
March 21, 2018: Gut
https://www.readbyqxmd.com/read/29545633/chronic-nausea-and-vomiting-evaluation-and-treatment
#8
REVIEW
Brian E Lacy, Henry P Parkman, Michael Camilleri
Nausea is an uneasy feeling in the stomach while vomiting refers to the forceful expulsion of gastric contents. Chronic nausea and vomiting represent a diverse array of disorders defined by 4 weeks or more of symptoms. Chronic nausea and vomiting result from a variety of pathophysiological processes, involving gastrointestinal and non-gastrointestinal causes. The prevalence of chronic nausea and vomiting is unclear, although the epidemiology of specific conditions, such as gastroparesis and cyclic vomiting syndrome, is better understood...
March 15, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29502568/col1a1-mutations-presenting-as-descending-perineum-syndrome-in-a-young-patient-with-hypermobility-syndrome
#9
Priya Vijayvargiya, Michael Camilleri, Robert R Cima
A 22-year-old woman presented with 12 years of progressive constipation; she had increased joint flexibility, hyperextensible skin, and excessive perineal descent on examination. Radiological studies confirmed evidence of rectal evacuation disorder due to descending perineum syndrome, enterocele, and rectocele. In a wide genetic screen (∼611,000 single nucleotide polymorphisms), 4 variations were identified in COL1A1 gene ([rs72656352, Chr17: 50,185,535-50,185,539, deletion], [rs72654794, Chr17: 50,188,575, deletion], [rs72667023, Chr17: 50,198,170, deletion], [rs67828806, Chr17: 50,198,177 G→C])...
March 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29470146/towards-an-effective-peripheral-visceral-analgesic-responding-to-the-national-opioid-crisis
#10
Michael Camilleri
This is an editorial summarizing recent new developments in visceral analgesics. This promising field is important as a new approach to address abdominal pain with peripheral visceral analgesics is considered a key approach to addressing the current opioid crisis. Some of the novel compounds address peripheral pain mechanisms through modulation of opioid receptors through biased ligands, nociceptin/orphanin FQ opioid peptide (NOP) receptor or dual action on NOP and μ-opioid receptor, buprenorphine and morphiceptin analogs...
February 22, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29408290/increased-prevalence-of-rare-sucrase-isomaltase-si-pathogenic-variants-in-irritable-bowel-syndrome-patients
#11
Koldo Garcia-Etxebarria, Tenghao Zheng, Ferdinando Bonfiglio, Luis Bujanda, Aldona Dlugosz, Greger Lindberg, Peter T Schmidt, Pontus Karling, Bodil Ohlsson, Magnus Simren, Susanna Walter, Gerardo Nardone, Rosario Cuomo, Paolo Usai-Satta, Francesca Galeazzi, Matteo Neri, Piero Portincasa, Massimo Bellini, Giovanni Barbara, Daisy Jonkers, Shanti Eswaran, William D Chey, Purna Kashyap, Lin Chang, Emeran A Mayer, Mira M Wouters, Guy Boeckxstaens, Michael Camilleri, Andre Franke, Mauro D'Amato
No abstract text is available yet for this article.
February 20, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29305933/effects-of-weight-loss-medications-on-cardiometabolic-risk-profiles-a-systematic-review-and-network-meta-analysis
#12
Rohan Khera, Ambarish Pandey, Apoorva K Chandar, Mohammad H Murad, Larry J Prokop, Ian J Neeland, Jarett D Berry, Michael Camilleri, Siddharth Singh
BACKGROUND & AIMS: We performed a systematic review and network meta-analysis to evaluate the overall and comparative effects of weight-loss medications approved by the Food and Drug Administration for long-term use on cardiometabolic risk profiles of obese adults. METHODS: We performed a systematic literature review through February 28, 2017 to identify randomized clinical trials of the effects of Food and Drug Administration-approved weight-loss medications (ie, orlistat, lorcaserin, naltrexone-bupropion, phentermine-topiramate, and liraglutide) administered to obese adults for 1 year or more, compared with placebo or another active agent...
April 2018: Gastroenterology
https://www.readbyqxmd.com/read/29243034/application-of-pyridostigmine-in-pediatric-gastrointestinal-motility-disorders-a-case-series
#13
Mhd Louai Manini, Michael Camilleri, Rayna Grothe, Carlo Di Lorenzo
BACKGROUND: Gastrointestinal (GI) motility disorders are common in children. Treatment is challenging with limited medical and surgical options. Pyridostigmine, an acetyl cholinesterase inhibitor, increases acetylcholine at the neuromuscular junction promoting intestinal contractions. Little is known about the role and dosing of pyridostigmine in pediatric GI motility disorders. METHODS: We present a case series of children with GI dysmotility managed with oral pyridostigmine...
April 2018: Paediatric Drugs
https://www.readbyqxmd.com/read/29239347/chronic-constipation
#14
REVIEW
Michael Camilleri, Alexander C Ford, Gary M Mawe, Phil G Dinning, Satish S Rao, William D Chey, Magnus Simrén, Anthony Lembo, Tonia M Young-Fadok, Lin Chang
Chronic constipation is a prevalent condition that severely impacts the quality of life of those affected. Several types of primary chronic constipation, which show substantial overlap, have been described, including normal-transit constipation, rectal evacuation disorders and slow-transit constipation. Diagnosis of primary chronic constipation involves a multistep process initiated by the exclusion of 'alarm' features (for example, unintentional weight loss or rectal bleeding) that might indicate organic diseases (such as polyps or tumours) and a therapeutic trial with first-line treatments such as dietary changes, lifestyle modifications and over-the-counter laxatives...
December 14, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29215610/breath-testing-consensus-guidelines-for-sibo-res-ipsa-locquitor
#15
William Paterson, Michael Camilleri, Magnus Simren, Guy Boeckxstaens, Stephen J Vanner
No abstract text is available yet for this article.
December 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29199141/effects-of-amitriptyline-and-escitalopram-on-sleep-and-mood-in-patients-with-functional-dyspepsia
#16
Linda M Herrick, Michael Camilleri, Cathy D Schleck, Alan R Zinsmeister, Yuri A Saito, Nicholas J Talley
BACKGROUND & AIMS: Tricyclic antidepressants are effective in reducing symptoms of functional dyspepsia (FD). We performed a post hoc analysis of data from a previous randomized clinical trial to determine whether the benefits of an antidepressant on gastrointestinal symptoms in patients with FD were mediated by improving sleep or reducing anxiety. We explored the relationships between psychological measures, quality of sleep, and relief of symptoms. METHODS: We analyzed data from a multicenter, double-blind trial that evaluated the efficacy of antidepressants on symptoms of FD, from October 2006 through October 2012...
March 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29189322/ulcerating-tumor-of-the-scalp-challenge
#17
Stanislav N Tolkachjov, Lisa A Drage, Lawrence E Gibson, Michael J Camilleri, David A Wetter
No abstract text is available yet for this article.
December 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29189319/ulcerating-tumor-of-the-scalp-answer
#18
Stanislav N Tolkachjov, Lisa A Drage, Lawrence E Gibson, Michael J Camilleri, David A Wetter
No abstract text is available yet for this article.
December 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29155353/advantages-and-limitations-of-the-federal-adverse-events-reporting-system-in-assessing-adverse-event-reporting-for-eluxadoline
#19
EDITORIAL
Victor Chedid, Priya Vijayvargiya, Michael Camilleri
No abstract text is available yet for this article.
March 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29102744/modulating-bile-acid-pathways-and-tgr5-receptors-for-treating-liver-and-gi-diseases
#20
REVIEW
Harmeet Malhi, Michael Camilleri
Bile acids are central signals in enterohepatic communication and also integrate microbiota-derived signals into this signaling axis. Discovery of the tissue distribution and signaling pathways activated by the natural receptors for bile acids, farnesoid X receptor and G protein-coupled bile acid receptor 1 (GPBAR1) also known as TGR5, and bile acid transporters has led to the development of therapeutic agents that target these molecules. Obeticholic acid, a selective FXR agonist, and NGM282, a non-mitogenic FGF-19 analog, are two of the agents in this pipeline...
December 2017: Current Opinion in Pharmacology
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