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Jan Tack

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https://www.readbyqxmd.com/read/27915009/exploring-gastrointestinal-variables-affecting-drug-and-formulation-behavior-methodologies-challenges-and-opportunities
#1
REVIEW
Bart Hens, Maura Corsetti, Robin Spiller, Luca Marciani, Tim Vanuytsel, Jan Tack, Arjang Talattof, Gordon L Amidon, Mirko Koziolek, Werner Weitschies, Clive G Wilson, Roelof J Bennink, Joachim Brouwers, Patrick Augustijns
Various gastrointestinal (GI) factors affect drug and formulation behavior after oral administration, including GI transfer, motility, pH and GI fluid volume and composition. An in-depth understanding of these physiological and anatomical variables is critical for a continued progress in oral drug development. In this review, different methodologies (invasive versus non-invasive) to explore the impact of physiological variables on formulation behavior in the human GI tract are presented, revealing their strengths and limitations...
November 30, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27865990/exploring-the-link-between-gastric-motility-and-intragastric-drug-distribution-in-man
#2
Jens Van Den Abeele, Joachim Brouwers, Jan Tack, Patrick Augustijns
In drug development, the stomach is often considered to be a simple, one-compartmental organ, a waiting room for transfer of an orally administered dosage form to the duodenum. However, factors such as gastric acidity and hydrodynamics in the gastric environment may influence drug disposition. Although a link between gastrointestinal drug behaviour and gastric motility has often been hypothesized, they have not been simultaneously investigated in humans yet. In this proof-of-concept study, the combination of a well-established intraluminal sampling technique with high-resolution manometric measurements in the gastrointestinal tract was evaluated...
November 16, 2016: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/27769304/3d-printing-techniques-in-a-medical-setting-a-systematic-literature-review
#3
Philip Tack, Jan Victor, Paul Gemmel, Lieven Annemans
BACKGROUND: Three-dimensional (3D) printing has numerous applications and has gained much interest in the medical world. The constantly improving quality of 3D-printing applications has contributed to their increased use on patients. This paper summarizes the literature on surgical 3D-printing applications used on patients, with a focus on reported clinical and economic outcomes. METHODS: Three major literature databases were screened for case series (more than three cases described in the same study) and trials of surgical applications of 3D printing in humans...
October 21, 2016: Biomedical Engineering Online
https://www.readbyqxmd.com/read/27693678/gastrointestinal-dissolution-supersaturation-and-precipitation-of-the-weak-base-indinavir-in-healthy-volunteers
#4
Jari Rubbens, Joachim Brouwers, Jan Tack, Patrick Augustijns
This study investigated the impact of relevant gastrointestinal conditions on the intraluminal dissolution, supersaturation and precipitation behavior of the weakly basic drug indinavir. The influence of (i) concomitant PPI intake and (ii) the nutritional state on the gastrointestinal behavior of indinavir was assessed in order to identify the underlying mechanisms responsible for previously reported interactions. Five healthy volunteers were recruited into a crossover study containing the following arms: fasted state, fed state and fasted state with concomitant proton pump inhibitor (PPI) use...
December 2016: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/27678159/regardless-of-etiology-progressive-renal-disease-causes-ultrastructural-and-functional-alterations-of-peritubular-capillaries
#5
Janka Bábíčková, Barbara M Klinkhammer, Eva M Buhl, Sonja Djudjaj, Mareike Hoss, Felix Heymann, Frank Tacke, Jürgen Floege, Jan U Becker, Peter Boor
Progressive renal diseases are associated with rarefaction of peritubular capillaries, but the ultrastructural and functional alterations of the microvasculature are not well described. To study this, we analyzed different time points during progressive kidney damage and fibrosis in 3 murine models of different disease etiologies. These models were unilateral ureteral obstruction, unilateral ischemia-reperfusion injury, and Col4a3-deficient mice, we analyzed ultrastructural alterations in patient biopsy specimens...
September 24, 2016: Kidney International
https://www.readbyqxmd.com/read/27639359/differential-brain-responses-to-gradual-intragastric-nutrient-infusion-and-gastric-balloon-distension-a-role-for-gut-peptides
#6
Huynh Giao Ly, Patrick Dupont, Koen Van Laere, Inge Depoortere, Jan Tack, Lukas Van Oudenhove
BACKGROUND: Rapid gastric balloon distension to discomfort threshold activates the "pain neuromatrix" and deactivates exteroceptive sensory and "default mode network" regions. However, little is known about brain mechanisms underlying tolerance of meal-induced gastric distension. We aimed to directly compare brain responses to gradual balloon distension and intragastric nutrient infusion and to explore the role of differential gut peptide release in these responses. MATERIALS AND METHODS: Brain responses to balloon- and nutrient-induced distension (to individually titrated pain or maximal satiation threshold) were measured in 15 healthy volunteers using H2(15)O-PET on 2 separate days in counterbalanced order...
September 14, 2016: NeuroImage
https://www.readbyqxmd.com/read/27621111/relevance-of-serum-sclerostin-concentrations-in-critically-ill-patients
#7
Alexander Koch, Ralf Weiskirchen, Sebastian Ludwig, Lukas Buendgens, Jan Bruensing, Eray Yagmur, Christer Baeck, Ulf Herbers, Christian Trautwein, Frank Tacke
PURPOSE: Sclerostin is a negative regulator of bone metabolism and associated with chronic morbidities. We investigated circulating sclerostin in critically ill patients. METHODS: A total of 264 patients (170 with sepsis) were studied prospectively upon admission to the medical intensive care unit (ICU) and on day 7. Patients' survival was followed for up to 3 years. RESULTS: Sclerostin serum levels were significantly elevated in critically ill patients at ICU admission compared with 99 healthy controls...
August 22, 2016: Journal of Critical Care
https://www.readbyqxmd.com/read/27596695/pan-colonic-pressurizations-associated-with-relaxation-of-the-anal-sphincter-in-health-and-disease-a-new-colonic-motor-pattern-identified-using-high-resolution-manometry
#8
Maura Corsetti, Giuseppe Pagliaro, Ingrid Demedts, Eveline Deloose, Annemie Gevers, Charlotte Scheerens, Nathalie Rommel, Jan Tack
OBJECTIVES: Only a few studies have applied high-resolution manometry (HRM) to the study of colonic motility in adults and none of them have concurrently evaluated colonic and anal motor activity. The aim of the study was to evaluate colonic and anal motor activity by means of HRM in healthy subjects. As the present study revealed the presence of a new colonic motor pattern (pan-colonic pressurizations) in healthy subjects, three additional studies were conducted: the first and the second to exclude that this motor event results from an artifact due to abdominal wall contraction and to confirm its modulation by cholinergic stimulation, and the third, as pilot study, to test the hypothesis that this colonic pattern is defective in patients with chronic constipation refractory to current pharmacological treatments...
September 6, 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27576295/an-in-depth-view-into-human-intestinal-fluid-colloids-intersubject-variability-in-relation-to-composition
#9
Danny Riethorst, Peter Baatsen, Caroline Remijn, Amitava Mitra, Jan Tack, Joachim Brouwers, Patrick Augustijns
Intestinal fluids dictate the intraluminal environment, and therefore, they substantially affect the absorption of orally taken drugs. The characterization of human intestinal fluids (HIF) and the design of simulated intestinal fluids (SIF) mainly focus on composition, not necessarily taking into account the ultrastructure of HIF. Colloidal structures in HIF and SIF can enhance the solubilizing capacity for lipophilic drugs while decreasing the bioaccessible fraction. As such, colloids present in HIF play a crucial role and require an in-depth characterization...
October 3, 2016: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/27557427/the-intragastric-pressure-measurement-a-novel-method-to-assess-gastric-accommodation-in-functional-dyspepsia-children
#10
Florencia Carbone, Jan Tack, Ilse Hoffman
: Impaired gastric accommodation (GA) is proposed as a main pathophysiological mechanism for functional dyspepsia (FD). At present, the gastric barostat is the gold standard to measure GA. Hence, this procedure is very invasive and it might alter gastric physiology. Recently, we proposed the measurement of intragastric pressure (IGP) by means of high resolution manometry during nutrient intake as a potential alternative for assessing GA in adults. OBJECTIVES: Our aim was first to study the feasibility of the IGP measurement with nutrient tolerance in children with FD and second to compare these results with young healthy adults...
August 24, 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27533315/esophageal-atresia-future-directions-for-research-on-the-digestive-tract
#11
Maissa Rayyan, Nathalie Rommel, Jan Tack, Jan Deprest, Karel Allegaert
Esophageal atresia (EA) is a congenital malformation defined by the discontinuity of the esophagus occurring in 2.4 in 10,000 births. As survival rates are high, the significant medical morbidity became more relevant. Short-term and long-term morbidities involve the respiratory and gastrointestinal system in the majority of the patients. The impact of this morbidity seems large enough to inspire researchers to develop experimental animal models that may help understanding the pathogenesis and pathophysiology...
August 17, 2016: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27490433/understanding-human-immune-function-using-the-resources-from-the-human-functional-genomics-project
#12
Mihai G Netea, Leo A B Joosten, Yang Li, Vinod Kumar, Marije Oosting, Sanne Smeekens, Martin Jaeger, Rob Ter Horst, Melanie Schirmer, Hera Vlamakis, Richard Notebaart, Norman Pavelka, Raul Raul Aguirre-Gamboa, Morris A Swertz, Rahajeng N Tunjungputri, Wouter van de Heijden, Eric A Franzosa, Aylwin Ng, Daniel Graham, Kara Lassen, Kiki Schraa, Romana Netea-Maier, Jan Smit, Quirijn de Mast, Frank van de Veerdonk, Bart Jan Kullberg, Cees Tack, Inge van de Munckhof, Joost Rutten, Jacqueline van der Graaf, Lude Franke, Marten Hofker, Iris Jonkers, Mathieu Platteel, Astrid Maatman, Jingyuan Fu, Alexandra Zhernakova, Jos W M van der Meer, Charles A Dinarello, Andre van der Ven, Curtis Huttenhouwer, Hans Koenen, Irma Joosten, Ramnik J Xavier, Cisca Wijmenga
No abstract text is available yet for this article.
August 4, 2016: Nature Medicine
https://www.readbyqxmd.com/read/27448273/differential-activation-in-amygdala-and-plasma-noradrenaline-during-colorectal-distention-by-administration-of-corticotropin-releasing-hormone-between-healthy-individuals-and-patients-with-irritable-bowel-syndrome
#13
Yukari Tanaka, Motoyori Kanazawa, Michiko Kano, Joe Morishita, Toyohiro Hamaguchi, Lukas Van Oudenhove, Huynh Giao Ly, Patrick Dupont, Jan Tack, Takuhiro Yamaguchi, Kazuhiko Yanai, Manabu Tashiro, Shin Fukudo
Irritable bowel syndrome (IBS) often comorbids mood and anxiety disorders. Corticotropin-releasing hormone (CRH) is a major mediator of the stress response in the brain-gut axis, but it is not clear how CRH agonists change human brain responses to interoceptive stimuli. We tested the hypothesis that brain activation in response to colorectal distention is enhanced after CRH injection in IBS patients compared to healthy controls. Brain H215O- positron emission tomography (PET) was performed in 16 male IBS patients and 16 age-matched male controls during baseline, no distention, mild and intense distention of the colorectum using barostat bag inflation...
2016: PloS One
https://www.readbyqxmd.com/read/27423779/lanreotide-autogel-in-the-treatment-of-idiopathic-refractory-diarrhea-results-of-an-exploratory-controlled-before-and-after-open-label-multicenter-prospective-clinical-trial
#14
Raf Bisschops, Vincent De Ruyter, Gauthier Demolin, Didier Baert, Tom Moreels, Piet Pattyn, Hans Verhelst, Luc Lepoutre, Joris Arts, Philip Caenepeel, Patrick Ooghe, Thierry Codden, Pascal Maisonobe, Elke Petrens, Jan Tack
PURPOSE: Chronic idiopathic diarrhea is the passage of loose stools >3 times daily, or a stool weight >200 g/d, persisting for >4 weeks without clear clinical cause. Patients refractory to standard anti-diarrhetics have limited treatment options. Somatostatin analogues have the ability to reduce gastrointestinal secretions and motility. This study evaluated the efficacy and safety of lanreotide Autogel(*) 120 mg in chronic idiopathic diarrhea. METHODS: Other anti-diarrhetics were not allowed during the study and were stopped at screening...
August 2016: Clinical Therapeutics
https://www.readbyqxmd.com/read/27340029/in-vitro-and-in-vivo-investigation-of-the-gastrointestinal-behavior-of-simvastatin
#15
Sophie Geboers, Jef Stappaerts, Jan Tack, Pieter Annaert, Patrick Augustijns
Simvastatin (SV) is marketed as a lactone ester prodrug which is hydrolyzed to the active simvastatin hydroxyacid (SVA). SV is characterized by a low solubility and undergoes extensive first-pass metabolism. In this study, the influence of the upper gastrointestinal environment on the intraluminal behavior of simvastatin was investigated by a series of in vitro experiments. Dissolution, stability and two-stage dissolution tests were performed using simulated and human gastrointestinal fluids. The dissolution studies revealed a relatively slow dissolution of SV as well as conversion of SV to SVA...
August 20, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27337985/complications-of-botulinum-toxin-injections-for-treatment-of-esophageal-motility-disorders%C3%A2
#16
Froukje B van Hoeij, Jan F Tack, John E Pandolfino, Joel M Sternbach, Sabine Roman, André J P M Smout, Albert J Bredenoord
In achalasia and spastic esophageal motility disorders, botulinum toxin (botox) injection is considered an effective and low-risk procedure for short-term symptom relief. It is mainly offered to medically high-risk patients. However, no analysis of risks of botox injections has been performed. To determine the incidence and risk factors of procedure-related complications after esophageal botox injections, we analyzed the records of all patients undergoing botox injection therapy for esophageal motility disorders at four university hospitals in Europe and North America between 2008 and 2014...
June 24, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/27331917/modern-management-of-irritable-bowel-syndrome-more-than-motility
#17
Jan Tack, Tim Vanuytsel, Maura Corsetti
In the treatment of irritable bowel syndrome (IBS), loperamide seems efficacious for diarrhea and ispaghula for constipation, while musculotropic spasmolytics may relieve abdominal pain. Antidepressants were found to be efficacious for abdominal pain, but their tolerance may be problematic and the therapeutic effect varied largely between trials. While meta-analyses suggest efficacy of probiotics as a group, the quality of the trials is often suboptimal and there is large variability. Lubiprostone, a chloride channel activator, and linaclotide, a guanylyl cyclase-C agonist, showed favorable effects on multiple symptoms in IBS with constipation...
2016: Digestive Diseases
https://www.readbyqxmd.com/read/27267380/eluxadoline-for-the-treatment-of-diarrhoea-predominant-irritable-bowel-syndrome
#18
Emidio Scarpellini, Lucrezia Laterza, Gianluca Ianiro, Jan Tack, Ludovico Abenavoli, Antonio Gasbarrini
INTRODUCTION: Irritable bowel syndrome (IBS) treatment is challenging physicians because of its multifactorial physiopathology. In particular, abdominal pain and diarrhea management lack one unique effective pharmacological remedy. Opioid receptors, present in the central nervous system (CNS) and the enteric nervous system (ENS), are involved in visceral sensitivity and gastrointestinal motility control. To date only a few opioid receptor modulators are currently in use for the treatment of IBS but with dosage limitations due to the early development of severe constipation...
July 2016: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/27147123/design-of-treatment-trials-for-functional-gastrointestinal-disorders
#19
E Jan Irvine, Jan Tack, Michael D Crowell, Kok Ann Gwee, Meiyun Ke, Max J Schmulson, William E Whitehead, Brennan Spiegel
This article summarizes recent progress and regulatory guidance on design of trials to assess the efficacy of new therapies for functional gastrointestinal disorders (FGIDs). The double-masked, placebo-controlled, parallel-group design remains the accepted standard for evaluating treatment efficacy. A control group is essential, and a detailed description of the randomization process and concealed allocation method must be included in the study report. The control will most often be placebo, but for therapeutic procedures and for behavioral treatment trials, respectively, a sham procedure and control intervention with similar expectation of benefit, but lacking the treatment principle, are recommended...
May 2016: Gastroenterology
https://www.readbyqxmd.com/read/27147122/gastroduodenal-disorders
#20
Vincenzo Stanghellini, Francis K L Chan, William L Hasler, Juan R Malagelada, Hidekazu Suzuki, Jan Tack, Nicholas J Talley
Symptoms that can be attributed to the gastroduodenal region represent one of the main subgroups among functional gastrointestinal disorders. A slightly modified classification into the following 4 categories is proposed: (1) functional dyspepsia, characterized by 1 or more of the following: postprandial fullness, early satiation, epigastric pain, and epigastric burning, which are unexplained after a routine clinical evaluation; and includes 2 subcategories: postprandial distress syndrome that is characterized by meal-induced dyspeptic symptoms and epigastric pain syndrome that does not occur exclusively postprandially; the 2 subgroups can overlap; (2) belching disorders, defined as audible escapes of air from the esophagus or the stomach, are classified into 2 subcategories, depending on the origin of the refluxed gas as detected by intraluminal impedance measurement belching: gastric and supragastric belch; (3) nausea and vomiting disorders, which include 3 subcategories: chronic nausea and vomiting syndrome; cyclic vomiting syndrome; and cannabinoid hyperemesis syndrome; and (4) rumination syndrome...
May 2016: Gastroenterology
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