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https://www.readbyqxmd.com/read/28845321/evaluation-of-anterior-segment-changes-of-patients-taking-alpha1-blockers-by-ultrasound-biomicroscopy-in-the-drug-free-period
#1
Yeliz Acar, Kadir Eltutar, Sibel Zırtıloğlu
OBJECTIVES: To evaluate and compare anterior segment changes in patients taking alpha-1 (α1) blockers (tamsulosin, terazosin, doxazosin, alfuzosin) for benign prostatic hypertrophy, during drug intake and drug-free period, using ultrasound biomicroscopy (UBM). MATERIALS AND METHODS: In this prospective study, UBM was done before and after pupil dilatation in 31 phakic eyes of 19 male patients taking α1-blockers. Undilated and dilated UBM was repeated before cataract extraction, after stopping the drug for 10 days...
August 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28775239/reversion-of-epithelial-mesenchymal-transition-by-a-novel-agent-dz-50-via-igf-binding-protein-3-in-prostate-cancer-cells
#2
Zheng Cao, Shahriar Koochekpour, Stephen E Strup, Natasha Kyprianou
Dysregulation of transforming growth factor-β1 (TGF-β1) and insulin-like growth factor (IGF) axis has been linked to reactive stroma dynamics in prostate cancer progression. IGF binding protein-3 (IGFBP3) induction is initiated by stroma remodeling and could represent a potential therapeutic target for prostate cancer. In previous studies a lead quinazoline-based Doxazosin® derivative, DZ-50, impaired prostate tumor growth by targeting proteins involved in focal adhesion, anoikis resistance and epithelial-mesenchymal-transition (EMT)...
July 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28750355/doxazosin-nanoencapsulation-improves-its-in-vitro-antiproliferative-and-anticlonogenic-effects-on-breast-cancer-cells
#3
J Krai, A Beckenkamp, M M Gaelzer, A R Pohlmann, S S Guterres, E C Filippi-Chiela, C Salbego, A Buffon, R C R Beck
Doxazosin has been evaluated for the treatment of several types of cancer. Here, the antitumor effect of the nanoencapsulated form of doxazosin was evaluated in an in vitro model of breast cancer (MCF7 cell line). Doxazosin-loaded polymeric nanocapsules (DXZ-NC) were produced by interfacial deposition of preformed polymer with homogeneous aspect, spherical shape, mean diameter of about 130nm, positive zeta potential (+5mV), and encapsulation efficiency close to 35%. The Alamar Blue(®) assay and cell counting were carried out to assess cell viability and cell number, respectively...
October 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28740068/a-case-report-of-cystic-pheochromocytoma
#4
Shoaib Z Junejo, Sandeep Tuli, David M Heimann, Issac Sachmechi, David Reich
BACKGROUND Pheochromocytoma is a rare catecholamine-producing tumor with an estimated incidence of less than 0.1% in the global population. We present a case of cystic pheochromocytoma that was diagnosed as an incidental finding. The patient presented with abdominal pain and had a history of hypertension. CASE REPORT A 64-year-old man with hypertension presented with a clinical history of intermittent abdominal pain for one year. He denied sweating, palpitations, headache or back pain. He was found to have an elevated blood pressure of 170/90 and no palpable abdominal mass...
July 25, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28715066/comparison-of-phenoxybenzamine-and-doxazosin-in-perioperative-management-of-patients-with-pheochromocytoma
#5
Klaudia Malec, Piotr Miśkiewicz, Agnieszka Witkowska, Ewa Krajewska, Sadegh Toutounchi, Zbigniew Gałązka, Mariusz Piotrowski, Agata Kącka, Tomasz Bednarczuk, Urszula Ambroziak
BACKGROUND: adrenalectomy with preoperative pharmacological preparation is strongly recommended in patients diagnosed with pheochromocytoma in order to prevent perioperative complications. AIM: to compare phenoxybenzamine and doxazosin in terms of perioperative hemodynamic status in patients with pheochromocytoma prepared to adrenalectomy. METHODS: retrospective analysis of 44 patients with pheochromocytoma (aged 16-80 yr, female-29) who underwent adrenalectomy...
July 17, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28648579/release-mechanism-of-doxazosin-from-carrageenan-matrix-tablets-effect-of-ionic-strength-and-addition-of-sodium-dodecyl-sulphate
#6
Petra Kos, Matej Pavli, Saša Baumgartner, Ksenija Kogej
The polyelectrolyte matrix tablets loaded with an oppositely charged drug exhibit complex drug-release mechanisms. In this study, the release mechanism of a cationic drug doxazosin mesylate (DM) from matrix tablets based on an anionic polyelectrolyte λ-carrageenan (λ-CARR) is investigated. The drug release rates from λ-CARR matrices are correlated with binding results based on potentiometric measurements using the DM ion-sensitive membrane electrode and with molecular characteristics of the DM-λ-CARR-complex particles through hydrodynamic size measurements...
June 22, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28641581/thyrotoxic-and-pheochromocytoma-multisystem-crisis-a-case-report
#7
Kodai Suzuki, Takahito Miyake, Hideshi Okada, Fuminori Yamaji, Yuichiro Kitagawa, Tetsuya Fukuta, Ryu Yasuda, Yoshihito Tanaka, Haruka Okamoto, Sho Nachi, Tomoaki Doi, Takahiro Yoshida, Keisuke Kumada, Shozo Yoshida, Hiroaki Ushikoshi, Izumi Toyoda, Shinji Ogura
BACKGROUND: Thyrotoxic crisis and pheochromocytoma multisystem crisis are rare, life-threatening, emergency endocrine diseases with various clinical manifestations. Here we report a case of a patient who simultaneously developed thyrotoxic crisis and pheochromocytoma multisystem crisis and required intensive cardiovascular management. CASE PRESENTATION: A 60-year-old Asian man experienced nausea and vomiting, and subsequently developed dyspnea and cold sweats while farming...
June 23, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28559399/heterogeneity-in-early-responses-in-allhat-antihypertensive-and-lipid-lowering-treatment-to-prevent-heart-attack-trial
#8
RANDOMIZED CONTROLLED TRIAL
Sanket S Dhruva, Chenxi Huang, Erica S Spatz, Andreas C Coppi, Frederick Warner, Shu-Xia Li, Haiqun Lin, Xiao Xu, Curt D Furberg, Barry R Davis, Sara L Pressel, Ronald R Coifman, Harlan M Krumholz
Randomized trials of hypertension have seldom examined heterogeneity in response to treatments over time and the implications for cardiovascular outcomes. Understanding this heterogeneity, however, is a necessary step toward personalizing antihypertensive therapy. We applied trajectory-based modeling to data on 39 763 study participants of the ALLHAT (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial) to identify distinct patterns of systolic blood pressure (SBP) response to randomized medications during the first 6 months of the trial...
July 2017: Hypertension
https://www.readbyqxmd.com/read/28551590/higher-pretreatment-blood-pressure-is-associated-with-greater-alcohol-drinking-reduction-in-alcohol-dependent-individuals-treated-with-doxazosin
#9
Carolina L Haass-Koffler, Kimberly Goodyear, William H Zywiak, Molly Magill, Sarah E Eltinge, Paul M Wallace, Victoria M Long, Nitya Jayaram-Lindström, Robert M Swift, George A Kenna, Lorenzo Leggio
BACKGROUND: Preclinical and clinical research suggest that the α1 receptor antagonist prazosin reduces alcohol consumption. Furthermore, clinical studies indicate a role for prazosin in treating Post-Traumatic Stress Disorder (PTSD) symptoms and a recent trial suggested that pre-treatment blood pressure (BP) predicts therapeutic response for prazosin in PTSD patients. Whether pre-treatment BP may predict response to α1 blockers in alcohol-dependent (AD) patients is unknown. We previously reported a randomized controlled trial (RCT) where doxazosin, an α1 receptor antagonist with a more favorable pharmacokinetic profile than prazosin, reduced drinks per week (DPW) and heavy drinking days (HDD) in AD patients with a high family history density of alcoholism...
August 1, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28538203/uhplc-ms-ms-method-with-sample-dilution-to-test-therapeutic-adherence-through-quantification-of-ten-antihypertensive-drugs-in-urine-samples
#10
Amedeo De Nicolò, Valeria Avataneo, Franco Rabbia, Mauro Sciandra, Francesco Tosello, Jessica Cusato, Elisa Perlo, Paolo Mulatero, Franco Veglio, Giovanni Di Perri, Antonio D'Avolio
Nowadays, hypertension represents an important health problem, particularly in developed countries. In some cases the standard therapeutic approaches are not able to reestablish the normal blood pressure values: this condition is called "resistant hypertension". However, a fraction of cases of resistant hypertension are actually due to poor adherence to the prescribed therapy. Therapeutic Drug Monitoring could represent a direct and useful tool to correctly identify non-compliant patients. Nevertheless, high throughput methods for the simultaneous monitoring of a wide panel of drugs in the same analysis are lacking and, furthermore, there is not a generally acknowledged "standard" matrix for this test (plasma or urine)...
May 13, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28507312/design-and-evaluation-of-ephrina1-mutants-with-cerebral-protective-effect
#11
Yuanjun Zhu, Yuanqing Gao, Danping Zheng, Mengyang Shui, Kuai Yu, Xiaoyan Liu, Yuan Lin, Li Su, Wenxing Yang, Yinye Wang
The activation of EphA2 receptor by its natural ligand EphrinA1 causes blood brain barrier dysfunction, and inactivation of EphA2 reduces BBB damage in ischemic stroke. Thus, EphA2 targeted antagonists may serve as neuroprotective agents. We engineered four mutants of EphrinA1, EM1, EM2, EM3 and EM4, respectively. The computational analysis showed that these four mutants were capable of interacting with EphA2. Their potential neuroprotective effects were examined in mouse focal ischemia/reperfusion (I/R) model...
May 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28499171/quinazoline-based-%C3%AE-1-adrenoreceptor-antagonists-with-potent-antiproliferative-activity-in-human-prostate-cancer-cell-lines
#12
Valentina Maestri, Andrea Tarozzi, Elena Simoni, Antonio Cilia, Elena Poggesi, Marina Naldi, Benedetta Nicolini, Letizia Pruccoli, Michela Rosini, Anna Minarini
New α1-adrenoreceptor (α1-AR) antagonists related to prazosin and doxazosin were synthesized by replacing piperazine ring with (S)- or (R)-3-aminopiperidine. Binding studies indicated that the S configuration at the 3-C position of the piperidine ring is crucial for an optimal interaction of the compounds at all three α1-AR subtypes. Quinazolines 9 and 10, bearing a quinone ring on the lateral chain, exhibited also potent antiproliferative activity in LNCaP androgen-sensitive prostate cancer cell lines, higher than that of doxazosin...
May 4, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28459764/the-effect-of-the-bedtime-dosing-doxazosin-on-nocturnal-hypoxia-triggered-blood-pressure-surge-in-a-young-adult-man-with-severe-obstructive-sleep-apnea-syndrome-and-a-history-of-three-recurrent-sleep-onset-strokes
#13
Tetsuro Yoshida, Mitsuo Kuwabara, Satoshi Hoshide, Kazuomi Kario
No abstract text is available yet for this article.
June 2017: Blood Pressure Monitoring
https://www.readbyqxmd.com/read/28440455/%C3%AE-adrenoceptor-mediated-enhanced-inducibility-of-atrial-fibrillation-in-a-canine-system-inflammation-model
#14
Ying-Ying Chen, Ze-Wei Sun, Jian-Ping Jiang, Xiao-Dong Kang, Lin-Lin Wang, Yue-Liang Shen, Xu-Dong Xie, Liang-Rong Zheng
The exact mechanism associated with inflammation and atrial fibrillation (AF) remains unknown. The aim of the present study was to investigate the roles of connexin 43 (Cx43) and a1‑adrenergic receptor (α1‑AR) activation in the pathogenesis of system inflammation‑induced AF. A canine model of chronic low‑grade system inflammation was established by administrating a low dose of lipopolysaccharide (LPS; 0.1 µg/kg) for 2 weeks. Programmed stimulation was applied on the right atrial appendage to determine the effective refractory periods (ERP) and the window of vulnerability (WOV)...
June 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28440105/effect-of-doxazosin-on-stress-reactivity-and-the-ability-to-resist-smoking
#15
Terril L Verplaetse, Andrea H Weinberger, Lindsay M Oberleitner, Kathryn Mz Smith, Brian P Pittman, Julia M Shi, Jeanette M Tetrault, Meaghan E Lavery, Marina R Picciotto, Sherry A McKee
Preclinical findings support a role for α1-adrenergic antagonists in reducing nicotine-motivated behaviors, but these findings have yet to be translated to humans. The current study evaluated whether doxazosin would attenuate stress-precipitated smoking in the human laboratory. Using a well-validated laboratory analogue of smoking-lapse behavior, this pilot study evaluated whether doxazosin (4 and 8 mg/day) versus placebo attenuated the effect of stress (vs neutral imagery) on tobacco craving, the ability to resist smoking and subsequent ad-libitum smoking in nicotine-deprived smokers ( n=35)...
April 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28349274/a-systematic-review-of-add-on-pharmacologic-therapy-in-the-treatment-of-resistant-hypertension
#16
REVIEW
Anita P Tataru, Arden R Barry
INTRODUCTION: The objective of this systematic review was to evaluate the efficacy and safety of add-on pharmacologic therapies in the treatment of resistant hypertension (RH), defined as blood pressure (BP) above target despite three antihypertensive agents. METHODS: A systematic search was performed in MEDLINE, Embase, CENTRAL, CINAHL, ClinicalTrials.gov, and Google Scholar (inception to June 2016) to identify randomized controlled trials (RCTs) that compared any antihypertensive agent with control in patients with RH...
August 2017: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/28272220/clinical-study-of-duloxetine-hydrochloride-combined-with-doxazosin-for-the-treatment-of-pain-disorder-in-chronic-prostatitis-chronic-pelvic-pain-syndrome-an-observational-study
#17
RANDOMIZED CONTROLLED TRIAL
Mingxin Zhang, Hanzhong Li, Zhigang Ji, Dexin Dong, Su Yan
To explore the safety and efficacy of the selective 5-serotonin and norepinephrine reuptake inhibitor duloxetine hydrochloride and alpha-adrenergic receptor blocker (alpha-blocker) doxazosin mesylate-controlled tablets in the treatment of pain disorder in chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).In all, 150 patients were enrolled and 126 patients completed the study (41 patients in the doxazosin group, 41 patients in the sertraline group, and 44 patients in the duloxetine group). This was an open randomized 6-month study...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27992238/antiangiogenic-effects-of-doxazosin-on-experimental-choroidal-neovascularization-in-mice
#18
Jiaxian Guo, Xueting Luo, Jian Liang, Meichun Xiao, Xiaodong Sun
PURPOSE: The present study was designed to evaluate the effects of doxazosin on experimental choroidal neovascularization (CNV) in mice. METHODS: Six- to 8-week-old male C57BL/6 mice were divided into a control group and a doxazosin-treated group (5 mg/kg, i.p., daily). Experimental CNV was induced by laser photocoagulation. Seven and 14 days after laser induction, fluorescein angiography, choroidal flat mounts, and histological studies were performed to evaluate the fluorescence leakage, area, and thickness of CNV lesions, respectively...
January 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27987130/ultrasound-image-features-of-intravesical-prostatic-protrusion-indicated-failure-of-medication-therapy-of-finasteride-and-doxazosin-in-patients-with-benign-prostatic-hyperplasia-luts-bph
#19
Qiang Liu, Yunkai Zhu, Jianping Liu, Jun Qi, Jian Kang
BACKGROUND: Intravesical prostatic protrusion (IPP) is a type of benign prostatic hyperplasia (BPH) adenoma, and it plays a critical role in the pathogenesis of bladder outlet obstruction in patients with lower urinary tract syndromes (LUTS/BPH). AIMS: The goal of this study was to investigate the effect of a combination therapy with finasteride and doxazosin on IPP in BPU/LUTS patients. METHODS: A total of 322 BPH patients with enlarged prostatic volume as well as moderate to severe symptom scores were enrolled and divided into four groups according to the degree of IPP (IPP > 10 mm, 5-10 mm, <5 mm and no IPP) in this study...
March 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/27981373/-combined-treatment-of-bps-with-tamsulosin-and-finasteride-literature-review-and-prescription-data
#20
K Höfner, S Ulrich, R Berges
Combined therapy of benign prostatic syndrome (BPS) with α1-blockers and 5α-reductase (5AR)-inhibitors is recommended according to two leading studies on doxazosin/finasteride and tamsulosin/dutasteride for all 10 in Germany possible combinations (five α1-blockers and two 5AR inhibitors). Because tamsulosin and finasteride predominate in the treatment of BPS in Germany, the role of the combination tamsulosin/finasteride and its scientific basis from clinical studies has been investigated. A pharmacoepidemiological extrapolation from receipts of pharmacy data centres showed a strong increase of the combination tamsulosin/finasteride since 2003...
May 2017: Der Urologe. Ausg. A
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