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https://www.readbyqxmd.com/read/29790305/lyme-disease-associated-igg4-autoantibodies-correlate-with-synovial-pathology-in-antibiotic-refractory-lyme-arthritis
#1
Katherine B Sulka, Klemen Strle, Jameson T Crowley, Robert B Lochhead, Robert Anthony, Allen C Steere
OBJECTIVE: To determine whether IgG subclasses of B. burgdorferi antibodies differ from those of 3 Lyme disease (LD)-associated autoantibodies. METHODS: The IgG antibody subclasses were determined by ELISA in serum samples from 215 patients representative of each of the 3 stages of Lyme disease. Antibody and cytokine profiles were measured in matched serum and synovial fluid (SF) samples from Lyme arthritis patients. Synovial tissue from patients with antibiotic-refractory arthritis was examined for histologic features, IgG subclasses of plasma cells, and mRNA subclass expression...
May 23, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29744961/segmental-membranous-nephropathy-with-severe-igg3-deposition
#2
Atsushi Kondo, Yuya Hashimura, Takamichi Uchiyama, Norishige Yoshikawa, Hirotaka Minami
No abstract text is available yet for this article.
May 9, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29737082/-study-on-construction-of-recombinant-bb-pgex-opri-vaccine-of-pseudomonas-aeruginosa-and-its-protection-effect
#3
Xiao Liu, Wen-Gui Li, Guang-Xu Luo
OBJECTIVE: To construct the recombinant Bb-pGEX- OprI vaccine of Pseudomonas aeruginosa (Pa) outer membrane protein I (OprI) and study its protection effect in mice against Pa. METHODS: The OprI gene was amplified by PCR,and cloned into pGEX-1λT to generate pGEX- OprI . The pGEX- OprI was transformed into Bifidobacterium bifidum (Bb) to construct recombinant Bb-pGEX- OprI vaccine by electroporation. After identification with double enzyme digestion,PCR and sequencing,the vaccine was then induced with IPTG,and its expression was analyzed and identified by SDS-PAGE and Western blot respectively...
January 2018: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/29733355/cytophilic-antibodies-against-key-plasmodium-falciparum-blood-stage-antigens-contribute-to-protection-against-clinical-malaria-in-a-high-transmission-region-of-eastern-india
#4
Ikhlaq Hussain Kana, Asier Garcia-Senosiain, Susheel K Singh, Régis Wendpayangde Tiendrebeogo, Bishwanath Kumar Chourasia, Pawan Malhotra, Surya K Sharma, Manoj K Das, Subhash Singh, Bright Adu, Michael Theisen
Background: The collection of clinical data from a tribal population in a malaria endemic area of India suggests the occurrence of naturally acquired immunity (NAI) against Plasmodium falciparum malaria. Methods: Quantity and functionality of Immunoglobulin G (IgG) antibodies against intact merozoites and recombinant proteins were assessed in a 13-month longitudinal cohort study of 121 individuals, 3-60 years of age. Results: Opsonic phagocytosis of merozoites activity was strongly associated (hazard ratio [HR] = 0...
May 4, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29731066/distribution-of-anti-abo-immunoglobulin-g-subclass-and-c1q-antibody-in-abo-incompatible-kidney-transplantation
#5
K H Lee, D I Won, J-M Yook, K Y Kim, S M Park, J H Park, E S Lee, J-H Lim, H-Y Jung, J-Y Choi, S-H Park, C-D Kim, Y-L Kim, H-K Kim, S Huh, J-H Cho
INTRODUCTION: To investigate the correlation between serum anti-ABO immunoglobulin G (IgG) and IgG subclasses, anti-ABO IgG subclasses were measured by flow cytometry (FCM) in ABO-incompatible (ABOi) kidney transplant recipients. We also evaluated baseline anti-ABO C1q antibody. METHOD: Baseline anti-ABO IgG titers were measured by both FCM and column agglutination technique methods in 18 ABOi kidney transplant recipients. The mean florescence intensity (MFI) ratios of baseline anti-ABO IgG subclasses and anti-ABO C1q antibody were obtained by FCM and followed-up after rituximab treatment, each plasmapheresis (PP) session, and kidney transplantation...
May 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29721239/meningitis-spondylodiscitis-pneumonia-and-septic-shock-with-streptococcus-pneumoniae-in-a-previously-healthy-woman-with-isolated-igg2-igg3-iga-deficiency-and-monoclonal-gammopathy-of-undetermined-significance
#6
Shahin Gaini, David Gudnason, Bjarni Á Steig, Jenny Jónsdóttir Nielsen
A 66 years old Caucasian woman with pneumococcal meningitis was treated and discharged after an uncomplicated course. Five months later she was readmitted with fever and right side abdominal pain and diagnosed with pneumococcal spondylodiscitis. One year later she was treated for a severe chest X-ray confirmed left lobar pneumonia. Two years later she was diagnosed with a pneumococcal pneumonia in her left lung with septic shock. An immune deficiency screen revealed slightly reduced IgA levels, low IgG2 levels, low IgG3 levels and high IgG1 levels...
March 29, 2018: Infectious Disease Reports
https://www.readbyqxmd.com/read/29712861/hcmv-glycoprotein-b-subunit-vaccine-efficacy-mediated-by-nonneutralizing-antibody-effector-functions
#7
Cody S Nelson, Tori Huffman, Jennifer A Jenks, Eduardo Cisneros de la Rosa, Guanhua Xie, Nathan Vandergrift, Robert F Pass, Justin Pollara, Sallie R Permar
Human cytomegalovirus (HCMV) is the most common congenital infection worldwide, frequently causing hearing loss and brain damage in afflicted infants. A vaccine to prevent maternal acquisition of HCMV during pregnancy is necessary to reduce the incidence of infant disease. The glycoprotein B (gB) + MF59 adjuvant subunit vaccine platform is the most successful HCMV vaccine tested to date, demonstrating ∼50% efficacy in preventing HCMV acquisition in multiple phase 2 trials. However, the mechanism of vaccine protection remains unknown...
April 30, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29709461/different-biochemical-patterns-in-type-ii-and-type-iii-mixed-cryoglobulinemia-in-hcv-positive-patients
#8
Umberto Basile, Francesca Gulli, Laura Gragnani, Krizia Pocino, Cecilia Napodano, Luca Miele, Stefano Angelo Santini, Mariapaola Marino, Anna Linda Zignego, Gian Ludovico Rapaccini
BACKGROUND: Reversible cryoprecipitability of proteins is observed as a concomitant feature of immune complex formation. Mixed cryoglobulinemia (MC) is systemic vasculitis, associated with mixed IgM and IgG cryoglobulins (CGs) showing rheumatoid factor (RF) activity. It is frequently associated with hepatitis C virus (HCV). This study investigates the presence of IgG RF and anti-nuclear antibodies (ANA) in cryoprecipitates of patients with type III and type II MC, to understand the biochemical patterns associated with different types of MC to a greater degree...
April 4, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29706136/human-antibodies-activate-complement-against-plasmodium-falciparum-sporozoites-and-are-associated-with-protection-against-malaria-in-children
#9
Liriye Kurtovic, Marije C Behet, Gaoqian Feng, Linda Reiling, Kiprotich Chelimo, Arlene E Dent, Ivo Mueller, James W Kazura, Robert W Sauerwein, Freya J I Fowkes, James G Beeson
BACKGROUND: Antibodies targeting Plasmodium falciparum sporozoites play a key role in human immunity to malaria. However, antibody mechanisms that neutralize sporozoites are poorly understood. This has been a major constraint in developing highly efficacious vaccines, as we lack strong correlates of protective immunity. METHODS: We quantified the ability of human antibodies from malaria-exposed populations to interact with human complement, examined the functional effects of complement activity against P...
April 30, 2018: BMC Medicine
https://www.readbyqxmd.com/read/29703767/encephalitis-with-mglur5-antibodies-symptoms-and-antibody-effects
#10
Marianna Spatola, Lidia Sabater, Jesús Planagumà, Eugenia Martínez-Hernandez, Thaís Armangué, Harald Prüss, Takahiro Iizuka, Ruben L Caparó Oblitas, Jean-Christophe Antoine, Richard Li, Nicholas Heaney, Niall Tubridy, Elvira Munteis Olivas, Myrna R Rosenfeld, Francesc Graus, Josep Dalmau
OBJECTIVE: To report the clinical features of 11 patients with metabotropic glutamate receptor 5 (mGluR5) antibody-associated encephalitis, immunoglobulin G (IgG) subclass, and effects of the antibodies on neuronal mGluR5 clusters. METHODS: Clinical information was retrospectively obtained from referring physicians. Antibodies to mGluR5 and IgG subclasses were determined with brain immunohistochemistry and cell-based assays. The effects of the antibodies were examined on rat hippocampal neurons with reported techniques...
April 27, 2018: Neurology
https://www.readbyqxmd.com/read/29684416/development-of-antibody-biomarkers-of-long-term-and-recent-dengue-virus-infections
#11
Eduardo J M Nascimento, James W Huleatt, Marli T Cordeiro, Priscila M S Castanha, James K George, Eduard Grebe, Alex Welte, Monique Brown, Donald S Burke, Ernesto T A Marques
Dengue virus (DENV) infections elicit antibody responses to the non-structural protein 1 (NS1) that are associated with protection against disease. However, the antibody isotypes and subclasses involved, and their kinetics have not been extensively studied. We characterized the antibody responses to DENV NS1 by enzyme-linked immunosorbent assay (ELISA) in a longitudinal cohort of 266 confirmed dengue cases in Recife, Northeast Brazil. Samples were collected during the febrile phase and up to over 3 years after onset of symptoms...
April 20, 2018: Journal of Virological Methods
https://www.readbyqxmd.com/read/29618330/filaria-specific-antibody-response-profiling-in-plasma-from-anti-retroviral-na%C3%A3-ve-loa-loa-microfilaraemic-hiv-1-infected-people
#12
Ghislain Donald Njambe Priso, Abel Lissom, Loveline N Ngu, Nadesh N Nji, Jules Colince Tchadji, Thibau Flaurant Tchouangueu, Georgia E Ambada, Carole Stéphanie Sake Ngane, Brigitte Laure Dafeu, Larissa Djukouo, Inès Nyebe, Suzanne Magagoum, Apeh Alfred Ngoh, Ouambo Fotso Herve, Rosario Garcia, Anna Gutiérrez, Arinze S Okoli, Charles O Esimone, Flobert Njiokou, Chae Gyu Park, Alain Bopda Waffo, Godwin W Nchinda
BACKGROUND: In West and Central Africa areas of endemic Loa loa infections overlap with regions of high prevalence of human immunodeficiency virus type 1 (HIV-1) infections. Because individuals in this region are exposed to filarial parasites from birth, most HIV-1 infected individuals invariably also have a history of filarial parasite infection. Since HIV-1 infection both depletes immune system and maintains it in perpetual inflammation, this can hamper Loa loa filarial parasite mediated immune modulation, leading to enhanced loaisis...
April 4, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29616329/proliferative-glomerulonephritis-with-monoclonal-igg-deposits-in-children-and-young-adults
#13
Guolan Xing, Robert Gillespie, Badreldin Bedri, Albert Quan, Pingchuan Zhang, Xin J Zhou
BACKGROUND: Proliferative glomerulonephritis with monoclonal IgG deposits (PGNMID) has been recognized as a distinct entity in recent years. To the best of our knowledge, all patients with PGNMID reported thus far were older than 20 years of age. We now report five cases of PGNMID in patients under 20 years of age. METHODS: The clinical database was searched for patients with native kidney biopsies from 9/2011 to 8/2017, and cases with a diagnosis of PGNMID were retrieved...
April 3, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29603375/age-specific-pediatric-reference-ranges-for-immunoglobulins-and-complement-proteins-on-the-optilite-%C3%A2-automated-turbidimetric-analyzer
#14
Marina Garcia-Prat, Gemma Vila-Pijoan, Susana Martos Gutierrez, Guadalupe Gala Yerga, Esther García Guantes, Mónica Martínez-Gallo, Andrea Martín-Nalda, Pere Soler-Palacín, Manuel Hernández-González
BACKGROUND: Measurement of immunoglobulins and complement proteins are frontline tests used in the assessment of immune system integrity, and reference values can vary with age. Their measurement provides an insight into the function of the innate and adaptive immune systems. METHODS: We generated pediatric reference ranges for IgG, IgA, IgM, IgD, the IgG and IgA subclasses, and C3 and C4 using the Optilite™ turbidimetric analyzer. RESULTS: The concentrations of IgG, IgA, and IgD showed an increase with age, as expected, while IgM remained stable between the age groups...
March 30, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29578484/hsv-1-specific-igg-subclasses-distribution-and-serum-neutralizing-activity-in-alzheimer-s-disease-and-in-mild-cognitive-impairment
#15
Simone Agostini, Roberta Mancuso, Ambra Hernis, Andrea Saul Costa, Raffaello Nemni, Mario Clerici
Human Herpes Simplex Virus type 1 (HSV-1) infection is suggested to play a role in the development of Alzheimer's disease (AD). Immunoglobulin G (IgG) neutralize HSV-1 activity, but the virus can evade IgG-mediated immune responses by expressing receptor that efficiently binds the Fc portion of all IgG subclasses with the exception of IgG3. We analyzed HSV-1-specific IgG subclasses and IgG-mediated serum neutralization activity against HSV-1 in individuals with a diagnosis of either AD or mild cognitive impairment (MCI), comparing the results with those obtained in age-matched healthy controls (HC)...
March 23, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29573417/what-do-anti-toxoplasma-gondii-iga-and-igg-subclasses-in-human-saliva-indicate
#16
I Cañedo-Solares, F Gómez-Chávez, H Luna-Pastén, L B Ortiz-Alegría, Y Flores-García, R Figueroa-Damián, C A Macedo-Romero, D Correa
Diagnostic tests for toxoplasmosis are based on serological techniques due to their high sensitivity. Some IgG subclasses are related to clinical outcome in the congenital form. In this work, we determined the levels of IgG, IgA, IgG1, IgG2, IgG3 and IgG4 anti-Toxoplasma gondii antibodies in paired saliva and serum samples from 91 women by indirect ELISA using a crude extract of the RH strain. The levels of IgA, IgG2, IgG3 and IgG4 antibodies and, to a lesser extent, IgG1 did not correlate between saliva and serum, that is, most cases that were positive for one Ig class in a sample were negative or very low in the other, and vice versa...
May 2018: Parasite Immunology
https://www.readbyqxmd.com/read/29550761/identification-of-igg3-specific-epitope-that-remedies-problem-in-diagnostic-igg-subclass-determination-due-to-human-genetic-variation
#17
Heather L Howie, Xiaohong Wang, Linda Kapp, Jenna N Lebedev, James C Zimring
There are four subtypes of human IgG with different effector functions. Quantifying the relative amount of each IgG subtype is important for laboratory diagnosis in multiple settings. However, in an evolving landscape of the appreciation of human variability and the need for precision/personalised laboratory diagnosis, it has also been shown that there are numerous natural variants of IgG subtypes, with at least 29 having been described. It has recently been reported that commercially available polyclonal antisera to IgG3 cross react with variants of other IgG subtypes, while available monoclonal anti-IgG3 have a blind-spot for the IgG3-04 variant...
June 2018: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29523330/igg-subclasses-response-to-a-set-of-mycobacterial-antigens-in-different-stages-of-mycobacterium-tuberculosis-infection
#18
Leonardo Silva de Araujo, Nidai de Bárbara Moreira da Silva, Janaina Aparecida Medeiros Leung, Fernanda Carvalho Queiroz Mello, Maria Helena Féres Saad
Despite the reported high heterogeneity of the human immune response to tuberculosis (TB), new studies may contribute to the understanding of Mycobacterium tuberculosis immunopathogenesis. To investigate the patterns of humoral response during latent (LTBI) and active TB, we evaluated specific IgG subclasses' response, by ELISA, to a set of mycobacterial antigens (Rv2029c, Rv2031c, Rv2034, Rv2628, Rv3353c ESAT6:CFP10, and the new chimeric PstS1(285-374) :CFP10) in plasma samples from exposed uninfected controls (ExC, n = 24), LTBI (n = 61), and TB (n = 15) donors...
January 2018: Tuberculosis
https://www.readbyqxmd.com/read/29520274/single-domain-antibodies-and-the-promise-of-modular-targeting-in-cancer-imaging-and-treatment
#19
REVIEW
María Elena Iezzi, Lucía Policastro, Santiago Werbajh, Osvaldo Podhajcer, Gabriela Alicia Canziani
Monoclonal antibodies and their fragments have significantly changed the outcome of cancer in the clinic, effectively inhibiting tumor cell proliferation, triggering antibody-dependent immune effector cell activation and complement mediated cell death. Along with a continued expansion in number, diversity, and complexity of validated tumor targets there is an increasing focus on engineering recombinant antibody fragments for lead development. Single-domain antibodies (sdAbs), in particular those engineered from the variable heavy-chain fragment (VHH gene) found in Camelidae heavy-chain antibodies (or IgG2 and IgG3), are the smallest fragments that retain the full antigen-binding capacity of the antibody with advantageous properties as drugs...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29514914/reduced-cell-associated-dna-and-improved-viral-control-in-macaques-following-passive-transfer-of-a-single-anti-v2-monoclonal-antibody-and-repeated-shiv-challenges
#20
Ann J Hessell, Mariya B Shapiro, Rebecca Powell, Delphine C Malherbe, Sean P McBurney, Shilpi Pandey, Tracy Cheever, William F Sutton, Christoph Kahl, Byung Park, Susan Zolla-Pazner, Nancy L Haigwood
A high level of V1V2-specific IgG antibodies in vaccinees' sera was the only independent variable that correlated with a reduced risk of HIV acquisition in the RV144 clinical trial. In contrast, IgG avidity, antibody neutralization, and antibody-dependent cellular cytotoxicity each failed as independent correlates of infection. Extended analyses of RV144 samples demonstrated antiviral activity of V1V2-specific vaccine-induced antibodies. V2-specific antibodies have also been associated with protection from SIV, and the V2i-specific subset of human monoclonal antibodies (mAbs), while poor neutralizers, mediate Fc-dependent antiviral functions in vitro The objective of this study was to determine the protective efficacy of a V2i-specific human mAb 830A against mucosal SHIV challenge...
March 7, 2018: Journal of Virology
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