keyword
https://read.qxmd.com/read/38044787/pediatric-corneal-transplantation-in-uyo-nigeria-early-experiences
#21
JOURNAL ARTICLE
E D Nkanga, Ui E Umana, A A Ibanga, E D Nkanga, E I Ezeh, E U Ani, D G Nkanga, B A Etim, S I Akpan
The burden of avoidable blindness from corneal disease is significantly higher where access to specialist eye care, the cost of treatment and the treatment infrastructure including eye banking, are beyond the reach of the impoverished masses. Corneal transplantation in children is challenging: it is more technically complex; patients often require multiple examinations under general anaesthesia to optimize treatment outcomes. There is also the increased risk of several complications including graft dehiscence, infection, rejection, and inappropriate patient or caregiver care...
November 1, 2023: Nigerian Journal of Clinical Practice
https://read.qxmd.com/read/38044450/congenital-herpes-simplex-with-ophthalmic-and-multisystem-features-a-case-report
#22
JOURNAL ARTICLE
Samuel Montenegro Pereira, Rian Vilar Lima, Maria Carolina Rocha Muniz, Marcus Breno Farias Araújo, Luiz de Moraes Ferreira Júnior, Juliana Tiburtino de Queiroz Sales Martins, Cláudia Faustino Coelho Luz, David Antônio Camelo Cid, Daniel da Rocha Lucena
BACKGROUND: Neonatal herpes simplex virus (HSV) infection is rare and has significant morbimortality rates. Approximately 85% of newborns are infected intrapartum, and risk factors for mother-to-child transmission include vaginal delivery, primary maternal infection, and prolonged rupture of membranes. Neonatal HSV can manifest with isolated mucocutaneous lesions, neurological involvement, or disseminated disease. In general, herpetic infection can cause blepharoconjunctivitis or keratitis...
December 4, 2023: BMC Pediatrics
https://read.qxmd.com/read/38038483/diagnostic-performance-of-real-time-quantitative-pcr-in-tear-samples-in-various-subtypes-of-herpes-simplex-keratitis
#23
JOURNAL ARTICLE
Gautier Hoarau, Oscar Haigh, Christelle Vauloup-Fellous, Rafaël Boucher, Alexandra Rouquette, Pascale Faure, Lamia Limam, Marc Labetoulle, Antoine Rousseau
Diagnosis of herpes simplex keratitis (HSK) is mostly based on clinical findings, yet biological confirmation supports management of challenging cases. This study evaluated the place of real-time quantitative PCR (RT-qPCR) on tear samplings in the management of HSK. Clinical records of patients who underwent tear sampling tested by RT-qPCR for herpes simplex virus type 1 for an acute episode of corneal inflammation or defect between January 2013 and December 2021 were retrospectively reviewed, and results were compared to clinical diagnosis (i...
December 1, 2023: Journal of Clinical Microbiology
https://read.qxmd.com/read/38034811/highly-sensitive-and-naked-eye-detection-of-herpes-simplex-virus-type-1-using-lamp-crispr-cas12-diagnostic-technology-and-gold-nanoparticles
#24
JOURNAL ARTICLE
Mengqi Huang, Yihong Chen, Libin Zheng, Yu-Feng Yao
Herpes simplex virus type 1 (HSV-1) Keratitis (HSK) is a highly prevalent eye disease worldwide, characterized by lifelong recurrent episodes and a major risk of leading to blindness. Detecting HSV-1 promptly and accurately can initiate a timely and appropriate therapeutic regimen, minimizing tissue damage and preventing vision impairment. Currently, PCR is the most reliable method for identifying HSV-1, but its utilization for point-of-care (POC) HSV-1 detection is limited due to the need for sophisticated equipment, particularly in areas with limited resources...
November 2023: Heliyon
https://read.qxmd.com/read/38022132/atypical-ocular-toxoplasmosis-multifocal-segmental-retinal-arteritis-kyrieleis-arteritis-and-peripheral-choroidal-leision
#25
Joobin Khadamy
A 45-year-old immunocompetent man with a two-week history of unilateral painful red eye was referred to the university hospital for further investigation. High intraocular pressure, corneal edema, large pigmented keratic precipitates, cells and flares in the anterior chamber, patches of iris transillumination with atrophy, multifocal segmental retinal arteritis (SRA) or Kyrieleis arteritis, and peripheral choroidal elevation with overlying vitritis without adjacent old scars were observed. Toxoplasmosis, varicella-zoster virus, herpes simplex, and cytomegalovirus serologies (IgG) were positive...
October 2023: Curēus
https://read.qxmd.com/read/38015175/unique-attributes-of-guinea-pigs-as-new-models-to-study-ocular-herpes-pathophysiology-and-recurrence
#26
JOURNAL ARTICLE
Tejabhiram Yadavalli, Chandrashekhar Patil, Pankaj Sharma, Ipsita Volety, Hemant Borase, Divya Kapoor, Deepak Shukla
PURPOSE: The objective of this study was to explore the ocular and systemic outcomes of herpes simplex virus type 1 (HSV-1) infection in guinea pigs, to monitor the spontaneous reactivation of the virus, and to assess the effectiveness of various treatments, drawing comparisons to conventional rabbit models. METHODS: Guinea pigs and rabbits were infected in the right corneas with differing doses and strains of HSV-1. Observations were made over a 71-day period, focusing on comparing ocular lesions, viral shedding patterns, and weight loss between the two animal models...
November 1, 2023: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/37981051/targeted-delivery-of-herpes-simplex-virus-glycoprotein-d-to-cd169-macrophages-using-ganglioside-liposomes-alleviates-herpes-simplex-keratitis-in-mice
#27
JOURNAL ARTICLE
Wenhao Shen, Chenchen Wang, Jiaxuan Jiang, Yun He, Qi Liang, Kai Hu
Herpes simplex keratitis (HSK) is a common blinding corneal disease caused by herpes simplex virus type 1 (HSV-1) infection. Antiviral drugs and corticosteroids haven't shown adequate therapeutic efficacy. During the early stages of HSV-1 infection, macrophages serve as the first line of defense. In particular, CD169+ macrophages play an important role in phagocytosis and antigen presentation. Therefore, we constructed GM-gD-lip, a ganglioside GM1 liposome vaccine encapsulating HSV-1 glycoprotein D and targeting CD169+ macrophages...
November 17, 2023: Journal of Controlled Release
https://read.qxmd.com/read/37959793/large-subunit-of-the-human-herpes-simplex-virus-terminase-as-a-promising-target-in-design-of-anti-herpesvirus-agents
#28
JOURNAL ARTICLE
Victor P Krasnov, Valeriya L Andronova, Alexander V Belyavsky, Sophia S Borisevich, George A Galegov, Oleg F Kandarakov, Dmitry A Gruzdev, Olga A Vozdvizhenskaya, Galina L Levit
Herpes simplex virus type 1 (HSV-1) is an extremely widespread pathogen characterized by recurrent infections. HSV-1 most commonly causes painful blisters or sores around the mouth or on the genitals, but it can also cause keratitis or, rarely, encephalitis. First-line and second-line antiviral drugs used to treat HSV infections, acyclovir and related compounds, as well as foscarnet and cidofovir, selectively inhibit herpesvirus DNA polymerase (DNA-pol). It has been previously found that ( S )-4-[6-(purin-6-yl)aminohexanoyl]-7,8-difluoro-3,4-dihydro-3-methyl-2 H -[1,4]benzoxazine (compound 1 ) exhibits selective anti-herpesvirus activity against HSV-1 in cell culture, including acyclovir-resistant mutants, so we consider it as a lead compound...
October 31, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/37922039/new-onset-of-herpes-simplex-keratitis-after-blepharoplasty-case-series-and-review-of-the-literature
#29
REVIEW
Chen Shtayer, Asaf Friehmann, Arie Nemet
PURPOSE: To report 3 cases of new-onset herpes simplex keratitis (HSK) after uncomplicated extraocular plastic surgery and discuss potential risk factors. METHODS: This case series includes 3 patients who underwent uncomplicated blepharoplastic surgery. Within 2 weeks postoperatively, all patients reported ocular discomfort, and their ophthalmic examinations revealed corneal lesions suspicious of HSK. One case was confirmed as an active herpes infection, and the other 2 cases were clinically diagnosed with HSK...
November 2023: Ophthalmic Plastic and Reconstructive Surgery
https://read.qxmd.com/read/37823644/impaired-glucocorticoid-receptor-function-attenuates-herpes-simplex-virus-1-production-during-explant-induced-reactivation-from-latency-in-female-mice
#30
JOURNAL ARTICLE
Kelly S Harrison, Nishani Wijesekera, Anastasia G J Robinson, Vanessa C Santos, Robert H Oakley, John A Cidlowski, Clinton Jones
Following acute infection, sensory neurons in trigeminal ganglia (TG) are important sites for the life-long latency of human alpha-herpes virus 1 (HSV-1). Acute or chronic stress in humans correlates with increased reactivation from latency, which can lead to recurrent HSV-1 disease, for example, herpes labialis, herpes stromal keratitis, and encephalitis. The glucocorticoid receptor (GR) and the synthetic corticosteroid dexamethasone stimulate key viral transcriptional cis-regulatory modules, viral replication, and explant-induced reactivation from latency...
October 12, 2023: Journal of Virology
https://read.qxmd.com/read/37809344/herpetic-anterior-uveitis-following-covid-19-vaccines-a-case-series
#31
JOURNAL ARTICLE
Muriel Ott, Thanoosha Nagamany, Souska Zandi, Francesco Pichi, Aniruddha Agarwal, Ester Carreño, Vishali Gupta, Dilraj S Grewal, Emmett T Cunningham, Marion R Munk
PURPOSE: To report a case series of herpetic uveitis following COVID-19 vaccinations. METHODS: Demographic, clinical and treatment-related data of herpetic anterior uveitis cases was collected at five tertiary eye hospitals between January 2021 and June 2022. A retrospective database review at one of the centers comparing the number of cases of herpetic eye disease before and after the introduction of COVID-19 vaccination was performed as well. RESULTS: Twenty-four patients (9 female, 15 male) with a mean age of 54 years (range 28-83 years) were diagnosed with herpetic uveitis, reporting an onset of symptoms 3-42 days after the first, second or third dose of COVID-19 vaccination...
2023: Frontiers in Medicine
https://read.qxmd.com/read/37765049/therapeutic-potential-of-biochanin-a-in-herpes-simplex-keratitis
#32
JOURNAL ARTICLE
Nan Zhou, Deyuan Zheng, Qiao You, Taige Chen, Jiaxuan Jiang, Wenhao Shen, Di Zhang, Junpeng Liu, Deyan Chen, Kai Hu
Herpes simplex keratitis (HSK) is a blinding eye disease that is initiated by the herpes simplex virus type 1 (HSV-1). Resistance to acyclovir (ACV) and the side effects of corticosteroid drugs have become concerning issues, so it is crucial to develop new antivirals for treating HSK. In this study, we report that biochanin A (BCA), a naturally occurring flavonoid compound, provides multifaceted protective effects with anti-viral, anti-inflammatory, anti-oxidative stress and anti-apoptotic activities to alleviate HSK...
September 1, 2023: Pharmaceuticals
https://read.qxmd.com/read/37747039/herpes-simplex-dendritic-keratitis
#33
JOURNAL ARTICLE
Giuseppe Giannaccare, Massimiliano Borselli
New England Journal of Medicine, Volume 389, Issue 13, September 2023.
September 28, 2023: New England Journal of Medicine
https://read.qxmd.com/read/37743596/birth-prevalence-and-characteristics-of-congenital-corneal-opacities
#34
JOURNAL ARTICLE
Kaitlynn Borik, Brian G Mohney, David Hodge, Margaret M Reynolds
PURPOSE/AIM: To report the birth prevalence and natural history of congenital corneal opacities among a population-based cohort of children. MATERIALS AND METHODS: The medical records of patients <5 years diagnosed with a congenital onset corneal opacity while residing in Olmsted County, Minnesota, from January 1, 1977, through December 31, 2016, were retrospectively reviewed. RESULTS: Fourteen patients were diagnosed with a congenital corneal opacity during the 40-year study period for a birth prevalence of 1 in 5188 live births...
September 24, 2023: European Journal of Ophthalmology
https://read.qxmd.com/read/37713628/lately-diagnosed-acanthamoeba-keratitis-manifesting-as-an-intrastromal-corneal-abscess-a-case-report
#35
JOURNAL ARTICLE
Sepehr Feizi, Zahra Karjou, Hamed Esfandiari
A 42-year-old female contact lens wearer presented to a local emergency department with a 3-day history of decreased vision and ocular discomfort in her right eye. She was started on topical fluorometholone and oral acyclovir with initial diagnosis of herpes simplex keratitis. After 3 weeks of worsening symptoms, she was diagnosed with bacterial corneal ulcer and treated with levofloxacin eye drops every 2 hr. After 14 days of no improvement, she was referred to our clinic for further workup. Slitlamp examination demonstrated a solitary dense 3×3-mm infiltration involving anterior and central corneal stroma...
September 15, 2023: Eye & Contact Lens
https://read.qxmd.com/read/37668848/herpes-simplex-virus-keratitis-electronic-medical-records-driven-big-data-analytics-report-from-a-tertiary-eye-institute-of-south-india
#36
JOURNAL ARTICLE
Anthony Vipin Das, Gagan Satyashree, Joveeta Joseph, Bhupesh Bagga
OBJECTIVE: To describe the demographics and clinical profile of Herpes Simplex Virus (HSV) Keratitis in patients presenting to a multi-tier ophthalmology hospital network in South India. METHODS: We have reviewed the medical records of all patients having a clinical diagnosis of any form of HSV keratitis, seen between May 2012 and August 2020 across the L V Prasad Eye Institute network. All the further analyses of the groups were performed using the keywords used for making the diagnosis of HSV keratitis and the data were collected from the electronic medical record system...
September 5, 2023: International Ophthalmology
https://read.qxmd.com/read/37632997/luteolin-inhibits-herpes-simplex-virus-1-infection-by-activating-cyclic-guanosine-monophosphate-adenosine-monophosphate-synthase-mediated-antiviral-innate-immunity
#37
JOURNAL ARTICLE
Yuan Wang, Feng Li, Zexu Wang, Xiaowei Song, Zhe Ren, Xiao Wang, Yifei Wang, Kai Zheng
BACKGROUND: The successive outbreaks of large-scale infectious diseases due to virus infection have been a major threat to human health in recent decades. Herpes simplex virus I (HSV-1) is a widely-disseminated DNA virus that infects the central nervous system to cause herpes labialis, keratitis and herpes simplex virus encephalitis (HSE), resulting in recurrent lifelong clinical or subclinical episodes. Luteolin is a plant flavone that has been extensively used in the treatment of various human diseases, including carcinogenesis, inflammation and chronic degenerative diseases...
August 17, 2023: Phytomedicine
https://read.qxmd.com/read/37631985/bms-265246-a-cyclin-dependent-kinase-inhibitor-inhibits-the-infection-of-herpes-simplex-virus-type-1
#38
JOURNAL ARTICLE
Lefang Jiang, Yang Yu, Zhuogang Li, Yarou Gao, Haonan Zhang, Mingxin Zhang, Weihua Cao, Qun Peng, Xulin Chen
Herpes simplex virus type 1 (HSV-1) infections are prevalent illnesses that can cause mucocutaneous ulcerative disease, keratitis, and genital herpes. In patients with compromised immune systems, the infection can lead to serious problems, such as encephalitis. Additionally, neonatal infections can cause brain problems and even death. Current first-line antiviral drugs are nucleoside analog inhibitors that target viral polymerase, and resistant strains have emerged. As a result, new drugs with distinct action modes are needed...
July 28, 2023: Viruses
https://read.qxmd.com/read/37602179/cytomegalovirus-keratitis-in-acute-myeloblastic-leukemia
#39
Seyed-Hashem Daryabari, Seyed Aliasghar Mosavi, Mohsen Moghtaderi
A 58-year-old woman presented with acute myeloblastic leukemia (AML) developed a bilateral dendritic epithelial keratitis without retinitis. The patient was initially treated with oral acyclovir with a possible diagnosis of herpes simplex virus (HSV) keratitis. Polymerase chain reaction (PCR) was performed on ocular discharge specimens collected by soft-tipped applicators reported as cytomegalovirus (CMV). Then, acyclovir was discontinued and bilateral CMV keratitis was treated with IV ganciclovir and her epithelial lesions gradually disappeared...
2023: Oman Journal of Ophthalmology
https://read.qxmd.com/read/37547606/combined-versus-sequential-penetrating-keratoplasty-and-cataract-surgery-for-herpes-simplex-keratitis-a-retrospective-study
#40
JOURNAL ARTICLE
Yani Wang, Jun Cheng, Nannan Yang, Ting Li, Yanling Dong, Lixin Xie
PURPOSE: To compare the surgical outcomes of combined penetrating keratoplasty (PK) and cataract surgery with those of sequential surgery (cataract surgery after PK) for herpes simplex keratitis (HSK). METHODS: The medical records of consecutive patients diagnosed with HSK who underwent combined or sequential PK and cataract surgery in active and stable stages between June 2015 and June 2022 were reviewed retrospectively. Complications, graft survival, endothelial cell density (ECD), and final BCVA were compared and analyzed between both surgical methods in each stage...
2023: Frontiers in Medicine
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