Victor P Krasnov, Valeriya L Andronova, Alexander V Belyavsky, Sophia S Borisevich, George A Galegov, Oleg F Kandarakov, Dmitry A Gruzdev, Olga A Vozdvizhenskaya, Galina L Levit
Herpes simplex virus type 1 (HSV-1) is an extremely widespread pathogen characterized by recurrent infections. HSV-1 most commonly causes painful blisters or sores around the mouth or on the genitals, but it can also cause keratitis or, rarely, encephalitis. First-line and second-line antiviral drugs used to treat HSV infections, acyclovir and related compounds, as well as foscarnet and cidofovir, selectively inhibit herpesvirus DNA polymerase (DNA-pol). It has been previously found that ( S )-4-[6-(purin-6-yl)aminohexanoyl]-7,8-difluoro-3,4-dihydro-3-methyl-2 H -[1,4]benzoxazine (compound 1 ) exhibits selective anti-herpesvirus activity against HSV-1 in cell culture, including acyclovir-resistant mutants, so we consider it as a lead compound...
October 31, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry