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Herpes simplex keratitis

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https://www.readbyqxmd.com/read/28700252/modified-allogenic-simple-limbal-epithelial-transplantation-followed-by-keratoplasty-as-treatment-for-total-limbal-stem-cell-deficiency
#1
Alfonso Vasquez-Perez, Mayank A Nanavaty
PURPOSE: To describe a modified allogenic simple limbal epithelial transplant (SLET) technique with large donor tissue explants followed by keratoplasty. METHODS: A 69-year-old with conjunctival melanoma on her left eye developed total limbal stem cell deficiency (LSCD) after multiple cycles of topical mitomycin. She also had herpes stromal keratitis while on treatment with mitomycin. She underwent modified allogenic SLET with large donor limbal tissue explants glued on the cornea directly and the amniotic membrane placed over the limbal explants...
July 12, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28666730/risk-factors-for-secondary-glaucoma-in-herpetic-anterior-uveitis
#2
Lisette Hoeksema, Nomdo M Jansonius, Leonoor I Los
PURPOSE: To determine the incidence of elevated intraocular pressure (IOP) and secondary glaucoma in herpetic anterior uveitis (AU), due to either herpes simplex or varicella zoster virus, by using the Standardization of Uveitis Nomenclature (SUN) criteria, and to identify risk factors for the development of glaucoma. DESIGN: Retrospective, observational cohort study. METHODS: Patients with herpetic AU presenting themselves between 2001 and 2013 at the ophthalmology department of the University Medical Center Groningen were included...
June 27, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28637763/analysis-of-hsv-reactivation-in-explant-reveals-a-method-dependent-difference-in-measured-timing-of-reactivation
#3
Jessica R Doll, Nancy M Sawtell
Herpes simplex virus (HSV) infection is widespread in the human population. Following orofacial infection, HSV establishes latency in innervating sensory neurons, primarily located in the trigeminal ganglia. A central feature of HSV pathogenesis is the ability to periodically reactivate in those neurons and transport back to the body surface. Both transmission and disease; such as keratitis, encephalitis, and neurodegeneration, have been linked to reactivation. Despite invaluable insights obtained from model systems, interactions between viral and host functions that regulate reactivation are still incompletely understood...
June 21, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28591279/detection-of-herpes-simplex-1-and-2-and-varicella-zoster-virus-by-quantitative-real-time-polymerase-chain-reaction-in-corneas-from-patients-with-bacterial-keratitis
#4
Heloisa Nascimento, Aripuanã Watanabe, Ana Carolina Cabreira Vieira, Andrea Pelegrini, Maria Cecília Yu, Paulo José Martins Bispo, Celso Francisco Hernandes Granato, Ana Luisa Höfling-Lima
Objective: Bacterial keratitis occurs worldwide, and despite recent developments, it remains a potentially blinding condition. This study assesses the presence of herpes simplex virus (HSV-1 and -2) and varicella zoster virus (VZV) by quantitative real-time polymerase chain reaction (qPCR) in corneal scrapings from patients with bacterial keratitis. Methods: A total of 65 patients with clinical diagnoses of infectious corneal ulcers prospectively underwent clinical eye examinations...
March 2017: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28584076/frontline-science-aspirin-triggered-resolvin-d1-controls-herpes-simplex-virus-induced-corneal-immunopathology
#5
Naveen K Rajasagi, Siddheshvar Bhela, Siva Karthik Varanasi, Barry T Rouse
Stromal keratitis (SK) is a chronic immunopathological lesion of the eye, caused by HSV-1 infection, and a common cause of vision impairment in humans. The inflammatory lesions in the cornea are primarily caused by neutrophils with the active participation of CD4(+) T cells. Therefore, the targeting of these immune cell types and their products represents a potentially valuable form of therapy to reduce the severity of disease. Resolvin D1 (RvD1) and its epimer aspirin-triggered RvD1 (AT-RvD1) are lipid mediators derived from docosahexaenoic acid (DHA) and were shown to promote resolution in several inflammatory disease models...
June 5, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28559714/practice-patterns-for-herpes-simplex-keratitis-a-survey-of-ophthalmologists-in-gulf-coast-countries
#6
Mashael A Alkhayyal, Donald U Stone
PURPOSE: Herpes simplex is a common cause of visual disability, and there are published evidence-based guidelines for therapy. This survey aims to determine the preferred practice patterns of ophthalmologists in Gulf Coast Countries regarding herpetic eye disease, as well as identify areas of controversy or barriers to acceptance of evidence-based protocols. METHODS: Anonymous web-based survey of ophthalmologists in Saudi Arabia, Bahrain, the United Arab Emirates, and Oman...
April 2017: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/28520594/amplivue-is-a-practical-and-timely-test-for-the-detection-of-hsv-from-keratitis-specimens
#7
Regis P Kowalski, Lisa M Karenchak, Deepinder K Dhaliwal, Alex Mammen
OBJECTIVE: The laboratory diagnostic detection of herpes simplex virus (HSV) from eye samples must be practical, timely, and definitive for appropriate therapy. Although polymerase chain reaction (PCR) and/or cell culture can be definitive, HSV results can be delayed. Enzyme Linked Virus Inducible System (ELVIS) is a test that can provide results within 24 to 48 hr. We evaluated "AmpliVue HSV 1+2 Assay" as a molecular colorimetric test that can detect HSV (1 or 2) DNA within 1 hr. METHODS: Cornea/conjunctival samples were tested retrospectively with AmpliVue against 53 true-positive and 20 true-negative specimens collected in chlamydial transport medium...
May 16, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28513490/coexistence-of-herpes-simplex-virus-infection-in-microsporidial-stromal-keratitis-associated-with-granulomatous-inflammation
#8
Ruchi Mittal, Praveen K Balne, Srikant Sahu, Sujata Das, Savitri Sharma
BACKGROUND: Microsporidial stromal keratitis poses several diagnostic challenges. Patients may present with corneal ulceration, marked stromal thinning, or even as a quite corneal scar. The presentation of microsporidial stromal keratitis commonly mimics viral keratitis. Microbiology scrapings are usually helpful; however, scraping and culture-negative cases pose a significant diagnostic dilemma. Histopathological examination is diagnostic but shows varying degree of inflammation, predominantly composed of polymorphonuclear leukocytes...
April 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28495905/long-term-outcomes-of-the-boston-type-i-keratoprosthesis-in-eyes-with-previous-herpes-simplex-virus-keratitis
#9
Melinda Fry, Carolina Aravena, Fei Yu, Jaffer Kattan, Anthony J Aldave
PURPOSE: To report the long-term outcomes of the Boston type I keratoprosthesis (Kpro) in eyes with prior herpes simplex virus (HSV) keratitis. METHODS: Retrospective review of all Kpro procedures performed by a single surgeon from 1 May 2004 to 1 January 2015. RESULTS: 13 of 173 Kpro procedures were performed in 11 eyes with prior HSV keratitis. There was not a significant difference in the percentage of eyes with and without prior HSV keratitis with preoperative (9% vs 8%, p=1...
May 11, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28491875/understanding-the-role-of-chemokines-and-cytokines-in-experimental-models-of-herpes-simplex-keratitis
#10
REVIEW
Tayaba N Azher, Xiao-Tang Yin, Patrick M Stuart
Herpes simplex keratitis is a disease of the cornea caused by HSV-1. It is a leading cause of corneal blindness in the world. Underlying molecular mechanism is still unknown, but experimental models have helped give a better understanding of the underlying molecular pathology. Cytokines and chemokines are small proteins released by cells that play an important proinflammatory or anti-inflammatory role in modulating the disease process. Cytokines such as IL-17, IL-6, IL-1α, and IFN-γ and chemokines such as MIP-2, MCP-1, MIP-1α, and MIP-1β have proinflammatory role in the destruction caused by HSV including neutrophil infiltration and corneal inflammation, and other chemokines and cytokines such as IL-10 and CCL3 can have a protective role...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28489722/bilateral-herpetic-keratitis-after-bilateral-intravitreal-bevacizumab-for-exudative-macular-degeneration
#11
Angeline M Derham, Eric Chen, Vatinee Y Bunya, Ronan E OʼMalley
PURPOSE: To report a case of bilateral herpetic epithelial keratitis after bilateral intravitreal bevacizumab injections for the treatment of exudative age-related macular degeneration. METHODS: A 66-year-old man with diabetes and an extensive history of bilateral anti-vascular endothelial growth factor treatments for exudative age-related macular degeneration received an intravitreal bevacizumab injection in the right eye and triple therapy (bevacizumab, photodynamic therapy, and triamcinolone acetonide) in the left eye...
July 2017: Cornea
https://www.readbyqxmd.com/read/28451758/the-evaluation-of-diagnostic-efficiency-for-stromal-herpes-simplex-keratitis-by-the-combination-of-tear-hsv-siga-and-hsv-dna
#12
Jini Qiu, Feifei Huang, Zhujian Wang, Jianjiang Xu, Chaoran Zhang
PURPOSE: To assess the differential diagnostic values for stromal herpes simplex keratitis (HSK) by using tear HSV-sIgA, tear HSV-DNA, and the combination. METHODS: Tear samples for both eyes and the paired serum were collected from 187 stromal HSK and 56 controls. Enzyme-linked immune sorbent assay (ELISA) was used to analyze the tear HSV-sIgA and serum IgG/IgM/IgA. The levels of tear HSV-DNA were measured by polymerase chain reaction (PCR). RESULTS: The positive rates for tear HSV-sIgA and HSV-DNA were 36...
July 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28380101/the-outcome-of-penetrating-keratoplasty-for-corneal-scarring-due-to-herpes-simplex-keratitis
#13
Yesim Altay, Sema Tamer, Abdullah Sencer Kaya, Ozgur Balta, Ayse Burcu, Firdevs Ornek
Purpose: To determine the outcomes of penetrating keratoplasty (PK) for treatment of corneal scarring caused by Herpes simplex virus (HSV) keratitis, and whether the corneal scar type affects treatment outcome. Methods: A retrospective analysis of patients who underwent PK for HSV-related corneal scarring between January 2008 and July 2011 was performed. The patients were categorized into two groups. Group 1 consisted of patients with a quiescent herpetic corneal scar and group 2 consisted of patients who developed a corneal descemetocele or perforation secondary to persistent epithelial defects with no active stromal inflammation...
January 2017: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28378806/fibroblast-growth-factor-2-drives-and-maintains-progressive-corneal-neovascularization-following-hsv-1-infection
#14
H R Gurung, M M Carr, K Bryant, A J Chucair-Elliott, D Jj Carr
Herpes simplex virus type 1 (HSV-1) infection of the cornea induces vascular endothelial growth factor A (VEGF-A)-dependent lymphangiogenesis that continues to develop well beyond the resolution of infection. Inflammatory leukocytes infiltrate the cornea and have been implicated to be essential for corneal neovascularization, an important clinically relevant manifestation of stromal keratitis. Here we report that cornea infiltrating leukocytes including neutrophils and T cells do not have a significant role in corneal neovascularization past virus clearance...
April 5, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28374243/development-of-recombinant-hsv-based-vaccine-vectors
#15
Richard Voellmy, David C Bloom, Nuria Vilaboa, Joyce Feller
Herpes simplex virus (HSV) causes significant morbidity on the human population through such clinical syndromes as cold sores, genital herpes, herpes stromal keratitis, and encephalitis. Attempts to generate efficacious vaccines to date have failed. We have recently described the use of a conditionally replication-competent HSV-1 vector to immunize mice against a lethal challenge of HSV-1. The unique feature of this vaccine vector is that its replication is tightly controlled and can only occur in the presence of local heat and the presence of a small molecule inducer (an antiprogestin)...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28320407/association-between-sensitivity-of-viral-thymidine-kinase-associated-acyclovir-resistant-herpes-simplex-virus-type-1-and-virulence
#16
Natsumi Omura, Hikaru Fujii, Tomoki Yoshikawa, Souichi Yamada, Shizuko Harada, Takuya Inagaki, Miho Shibamura, Haruko Takeyama, Masayuki Saijo
BACKGROUND: Acyclovir (ACV)-resistant (ACVr) herpes simplex virus type 1 (HSV-1) infections are concern in immunocompromised patients. Most clinical ACVr HSV-1 isolates have mutations in the viral thymidine kinase (vTK) genes. The vTK-associated ACVr HSV-1 shows reduced virulence, but the association between the level of resistance and the virulence of the vTK-associated ACVr HSV-1 is still unclear. METHODS: The virulence in mice of 5 vTK-associated ACVr HSV-1 clones with a variety of ACV sensitivities, when inoculated through intracerebral and corneal routes, was evaluated in comparison with ACV-sensitive (ACVs) parent HSV-1 TAS...
March 21, 2017: Virology Journal
https://www.readbyqxmd.com/read/28278385/the-type-i-interferon-response-and-age-dependent-susceptibility-to-herpes-simplex-virus-infection
#17
Daniel Giraldo, Douglas R Wilcox, Richard Longnecker
Herpes simplex virus type 1 (HSV-1) is a highly prevalent human neurotropic pathogen. HSV-1 infection is associated with a variety of diseases ranging from benign orolabial lesions to more serious and even life-threatening conditions such as herpes simplex keratitis and herpes simplex encephalitis (HSE). HSE is a rare occurrence among healthy adult individuals, but newborns are a particularly susceptible population. Type I IFN signaling has been identified as a crucial component of the innate immune response to the control of HSV-1 infection...
May 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28275607/intracorneal-and-intraocular-invasion-of-ocular-surface-squamous-neoplasia-after-intraocular-surgery-report-of-two-cases-and-review-of-the-literature
#18
Juan C Murillo, Anat Galor, Michael C Wu, Natasha K Kye, James Wong, Ibrahim O Ahmed, Madhura Joag, Nabeel Shalabi, William Lahners, Sander Dubovy, Carol L Karp
PURPOSE: The aim of this paper was to describe 2 cases of ocular surface squamous neoplasia (OSSN) of the conjunctiva with intracorneal and intraocular extension following intraocular surgery. METHODS: We conducted a clinical pathological retrospective case series. RESULTS: Case 1 underwent cataract surgery in the setting of an unnoticed adjacent OSSN. An excisional biopsy with cryotherapy and intraoperative mitomycin C was subsequently performed, confirming OSSN...
January 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/28176902/herpes-simplex-keratitis-challenges-in-diagnosis-and-clinical-management
#19
REVIEW
Tayaba N Azher, Xiao-Tang Yin, Deena Tajfirouz, Andrew Jw Huang, Patrick M Stuart
Herpes simplex virus is responsible for numerous ocular diseases, the most common of which is herpetic stromal keratitis. This is a recurrent infection of the cornea that typically begins with a subclinical infection of the cornea that establishes a latent infection of sensory ganglia, most often the trigeminal ganglia. Recurring infections occur when the virus is reactivated from latency and travels back to the cornea, where it restimulates an inflammatory response. This inflammatory response can lead to decreased corneal sensation, scarring, and blindness...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28138334/atopic-keratoconjunctivitis-complicated-by-kocuria-koreensis-keratitis-the-first-case
#20
Noriko Inada, Jun Shoji, Satoru Yamagami
BACKGROUND: Patients with atopic dermatitis have a predisposition to Staphylococcus aureus and a Herpes simplex virus infection. The treatment of atopic diseases with steroid and immunosuppressive agents induces opportunistic infection. However, there is a concern regarding visual prognosis in patients with atopic keratoconjunctivitis (AKC) complicated with infectious keratitis. We report an unusual case of an atopic shield ulcer with Kocuria keratitis. CASE PRESENTATION: A 51-year-old Japanese man presented with a 14-day history of eye pain and visual loss in his left eye...
2017: Allergy, Asthma, and Clinical Immunology
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