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JOURNAL ARTICLE
Hayfa Sharif, Caroline L Hoad, Nichola Abrehart, Penny A Gowland, Robin C Spiller, Sian Kirkham, Sabarinathan Loganathan, Michalis Papadopoulos, Marc A Benninga, David Devadason, Luca Marciani
Recent magnetic resonance imaging (MRI) studies showed that colonic volumes in children are different between health and functional constipation. The length of the colon has however been rarely measured and principally using unphysiological colon preparations or cadaver studies. The main objective of this study was to measure the length of the undisturbed colon in children with functional constipation (FC) and healthy controls. Here, the colon of 19 healthy controls (10-18 years old) and 16 children with FC (7-18 years old) was imaged using MRI...
2024: PloS One
#2
EDITORIAL
Robin Spiller
No abstract text is available yet for this article.
October 2023: Alimentary Pharmacology & Therapeutics
#3
JOURNAL ARTICLE
Eva Niggl, Arjan Bouman, Lauren C Briere, Remco M Hoogenboezem, Ilse Wallaard, Joohyun Park, Jakob Admard, Martina Wilke, Emilio D R O Harris-Mostert, Minetta Elgersma, Jennifer Bain, Meena Balasubramanian, Siddharth Banka, Paul J Benke, Miriam Bertrand, Alyssa E Blesson, Jill Clayton-Smith, Jamie M Ellingford, Madelyn A Gillentine, Dana H Goodloe, Tobias B Haack, Mahim Jain, Ian Krantz, Sharon M Luu, Molly McPheron, Candace L Muss, Sarah E Raible, Nathaniel H Robin, Michael Spiller, Susan Starling, David A Sweetser, Isabelle Thiffault, Francesco Vetrini, Dennis Witt, Emily Woods, Dihong Zhou, Ype Elgersma, Annelot C M van Esbroeck
Heterogeneous nuclear ribonucleoprotein C (HNRNPC) is an essential, ubiquitously abundant protein involved in mRNA processing. Genetic variants in other members of the HNRNP family have been associated with neurodevelopmental disorders. Here, we describe 13 individuals with global developmental delay, intellectual disability, behavioral abnormalities, and subtle facial dysmorphology with heterozygous HNRNPC germline variants. Five of them bear an identical in-frame deletion of nine amino acids in the extreme C terminus...
August 3, 2023: American Journal of Human Genetics
#4
REVIEW
Alexander Yule, Darren Sills, Sherie Smith, Robin Spiller, Alan R Smyth
INTRODUCTION: Gastrointestinal (GI) related symptoms, complications, and comorbidities in cystic fibrosis (CF) are common and research to reduce their burden is a priority to the CF community. To enable future research, this review aimed to summarize the range of GI symptoms, complications and comorbidities seen in CF, the underlying pathophysiology, and treatments. AREAS COVERED: This was a rapid systematic review undertaken using the recommendations from the Cochrane Rapid Reviews Methods Group...
June 22, 2023: Expert Review of Respiratory Medicine
#5
EDITORIAL
David Gunn, Alexander Ford, Amanda Farrin, Robin Spiller
No abstract text is available yet for this article.
June 2023: Alimentary Pharmacology & Therapeutics
#6
JOURNAL ARTICLE
Meshari T Alshammari, Ali S Alyami, Victoria Wilkinson-Smith, Robin C Spiller, Penny Gowland, Luca Marciani, Gordon W Moran, Caroline L Hoad
BACKGROUND: Magnetic resonance imaging (MRI) tagging techniques have been applied to the GI tract to assess bowel contractions and content mixing. We aimed to evaluate the dependence of a tagging measurement (for assessing chyme mixing) on inter-observer variability in both the ascending colon (AC) and descending colon (DC) and to investigate the temporal variation and hence reliability of the colonic tagging technique by acquiring multiple measurements over time on healthy participants...
May 9, 2023: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
#7
JOURNAL ARTICLE
Thomas Sühn, Nazila Esmaeili, Sandeep Y Mattepu, Moritz Spiller, Axel Boese, Robin Urrutia, Victor Poblete, Christian Hansen, Christoph H Lohmann, Alfredo Illanes, Michael Friebe
The direct tactile assessment of surface textures during palpation is an essential component of open surgery that is impeded in minimally invasive and robot-assisted surgery. When indirectly palpating with a surgical instrument, the structural vibrations from this interaction contain tactile information that can be extracted and analysed. This study investigates the influence of the parameters contact angle α and velocity v→ on the vibro-acoustic signals from this indirect palpation. A 7-DOF robotic arm, a standard surgical instrument, and a vibration measurement system were used to palpate three different materials with varying α and v→...
March 15, 2023: Sensors
#8
JOURNAL ARTICLE
David Gunn, Rabia Topan, Lorna Barnard, Ron Fried, Ivana Holloway, Richard Brindle, Maura Corsetti, Mark Scott, Adam Farmer, Kapil Kapur, David Sanders, Maria Eugenicos, Nigel Trudgill, Peter Whorwell, John Mclaughlin, Ayesha Akbar, Lesley Houghton, Phil G Dinning, Qasim Aziz, Alexander C Ford, Amanda J Farrin, Robin Spiller
BACKGROUND: Ondansetron may be beneficial in irritable bowel syndrome with diarrhoea (IBS-D). AIM: To conduct a 12-week parallel group, randomised, double-blind, placebo-controlled trial of ondansetron 4 mg o.d. (titrated up to 8 mg t.d.s.) in 400 IBS-D patients. PRIMARY ENDPOINT: % responders using the Food and Drug Administration (FDA) composite endpoint. Secondary and mechanistic endpoints included stool consistency (Bristol Stool Form Scale) and whole gut transit time (WGTT)...
June 2023: Alimentary Pharmacology & Therapeutics
#9
JOURNAL ARTICLE
Jonna Jalanka, David Gunn, Gulzar Singh, Shanthi Krishnasamy, Melanie Lingaya, Fiona Crispie, Laura Finnegan, Paul Cotter, Louise James, Adam Nowak, Giles Major, Robin C Spiller
OBJECTIVES: Persistent bowel dysfunction following gastroenteritis (postinfectious (PI)-BD) is well recognised, but the associated changes in microbiota remain unclear. Our aim was to define these changes after gastroenteritis caused by a single organism, Campylobacter jejuni , examining the dynamic changes in the microbiota and the impact of antibiotics. DESIGN: A single-centre cohort study of 155 patients infected with Campylobacter jejuni . Features of the initial illness as well as current bowel symptoms and the intestinal microbiota composition were recorded soon after infection (visit 1, <40 days) as well as 40-60 days and >80 days later (visits 2 and 3)...
March 2023: Gut
#10
JOURNAL ARTICLE
Nikola Fritz, Sabrina Berens, Yuanjun Dong, Cristina Martínez, Stefanie Schmitteckert, Lesley A Houghton, Miriam Goebel-Stengel, Verena Wahl, Maria Kabisch, Dorothea Götze, Mauro D'Amato, Tenghao Zheng, Ralph Röth, Hubert Mönnikes, Jonas Tesarz, Felicitas Engel, Annika Gauss, Martin Raithel, Viola Andresen, Jutta Keller, Thomas Frieling, Christian Pehl, Christoph Stein-Thöringer, Gerard Clarke, Paul J Kennedy, John F Cryan, Timothy G Dinan, Eamonn M M Quigley, Robin Spiller, Caroll Beltrán, Ana María Madrid, Verónica Torres, Emeran A Mayer, Gregory Sayuk, Maria Gazouli, George Karamanolis, Mariona Bustamante, Xavier Estivil, Raquel Rabionet, Per Hoffmann, Markus M Nöthen, Stefanie Heilmann-Heimbach, Börge Schmidt, André Franke, Wolfgang Lieb, Wolfgang Herzog, Guy Boeckxstaens, Mira M Wouters, Magnus Simrén, Gudrun A Rappold, Maria Vicario, Javier Santos, Rainer Schaefert, Justo Lorenzo-Bermejo, Beate Niesler
Irritable bowel syndrome (IBS) is a gut-brain disorder of multifactorial origin. Evidence of disturbed serotonergic function in IBS accumulated for the 5-HT3 receptor family. 5-HT3 Rs are encoded by HTR3 genes and control GI function, and peristalsis and secretion, in particular. Moreover, 5-HT3 R antagonists are beneficial in the treatment of diarrhea predominant IBS (IBS-D). We previously reported on functionally relevant SNPs in HTR3A c.-42C > T (rs1062613), HTR3C p.N163K (rs6766410), and HTR3E c...
September 19, 2022: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
#11
JOURNAL ARTICLE
M Atanasov, N Spiller, F Neese
A mixed valence binuclear Fe2.5+ -Fe2.5+ (Robin-Day Class III) transition metal complex, [Fe2.5+ μTe2 Fe2.5+ ]1- , composed of two FeN2 Te2 pseudo-tetrahedral units with μ-bridging Te2- ligands was reported to exist in an unprecedented S = 3/2 ground state (Nature Chemistry, https://doi.org/10.1038/s41557-021-00853-5). For this and the homologous complexes containing Se2- and S2- , the Anderson-Hasegawa double exchange spin-Hamiltonian was broadly used to interpret the corresponding structural, spectroscopic and magnetic data...
August 31, 2022: Physical Chemistry Chemical Physics: PCCP
#12
MULTICENTER STUDY
Sabrina Berens, Yuanjun Dong, Nikola Fritz, Jutta Walstab, Mauro D'Amato, Tenghao Zheng, Verena Wahl, Felix Boekstegers, Justo Lorenzo Bermejo, Cristina Martinez, Stefanie Schmitteckert, Egbert Clevers, Felicitas Engel, Annika Gauss, Wolfgang Herzog, Robin Spiller, Miriam Goebel-Stengel, Hubert Mönnikes, Viola Andresen, Frieling Thomas, Jutta Keller, Christian Pehl, Christoph Stein-Thöringer, Gerard Clarke, Timothy G Dinan, Eamonn M Quigley, Gregory Sayuk, Magnus Simrén, Jonas Tesarz, Gudrun Rappold, Lukas van Oudenhove, Rainer Schaefert, Beate Niesler
BACKGROUND: Single-nucleotide polymorphisms (SNPs) of the serotonin type 3 receptor subunit ( HTR3 ) genes have been associated with psychosomatic symptoms, but it is not clear whether these associations exist in irritable bowel syndrome (IBS). AIM: To assess the association of HTR3 polymorphisms with depressive, anxiety, and somatization symptoms in individuals with IBS. METHODS: In this retrospective study, 623 participants with IBS were recruited from five specialty centers in Germany, Sweden, the United States, the United Kingdom, and Ireland...
June 7, 2022: World Journal of Gastroenterology: WJG
#13
JOURNAL ARTICLE
Neele S Dellschaft, Christabella Ng, Caroline Hoad, Luca Marciani, Robin Spiller, Iain Stewart, Alex Menys, Helen Barr, Penny A Gowland, Giles Major, Alan R Smyth
People with cystic fibrosis (CF) experience digestive symptoms but the mechanisms are incompletely understood. Here we explore causes and consequences of slower gastrointestinal transit using magnetic resonance imaging (MRI). Twelve people with CF and 12 healthy controls, matched for age and gender, underwent MRI scans, both fasted and after standardised meals, over 6.5 h. Fasted small bowel motility scores were lower in CF than in controls. No difference in ascending colon chyme T1 was detected. The difference in texture between small bowel and colon contents, seen in health, was diminished in CF...
May 2022: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
#14
JOURNAL ARTICLE
Chris Eijsbouts, Tenghao Zheng, Nicholas A Kennedy, Ferdinando Bonfiglio, Carl A Anderson, Loukas Moutsianas, Joanne Holliday, Jingchunzi Shi, Suyash Shringarpure, Alexandru-Ioan Voda, Gianrico Farrugia, Andre Franke, Matthias Hübenthal, Gonçalo Abecasis, Matthew Zawistowski, Anne Heidi Skogholt, Eivind Ness-Jensen, Kristian Hveem, Tõnu Esko, Maris Teder-Laving, Alexandra Zhernakova, Michael Camilleri, Guy Boeckxstaens, Peter J Whorwell, Robin Spiller, Gil McVean, Mauro D'Amato, Luke Jostins, Miles Parkes
Irritable bowel syndrome (IBS) results from disordered brain-gut interactions. Identifying susceptibility genes could highlight the underlying pathophysiological mechanisms. We designed a digestive health questionnaire for UK Biobank and combined identified cases with IBS with independent cohorts. We conducted a genome-wide association study with 53,400 cases and 433,201 controls and replicated significant associations in a 23andMe panel (205,252 cases and 1,384,055 controls). Our study identified and confirmed six genetic susceptibility loci for IBS...
November 2021: Nature Genetics
#15
JOURNAL ARTICLE
Neele Dellschaft, Caroline Hoad, Luca Marciani, Penny Gowland, Robin Spiller
BACKGROUND: New developments in MRI have allowed the non-invasive, accurate measurement of the small bowel water content (SBWC). AIMS: To collate studies measuring SBWC following ingestion of a range of foods in both health and disease to provide data for adequately powering future studies in this area. METHODS: This collation brings together 29 studies including 954 participants (530 healthy, 54 diverticulosis, 255 IBS, 53 functional constipation, 12 cystic fibrosis, 15 Crohn's disease, 20 coeliac disease, 15 scleroderma) which have been carried out in a single centre using comparable study designs...
October 30, 2021: Alimentary Pharmacology & Therapeutics
#16
RANDOMIZED CONTROLLED TRIAL
David Gunn, Zainab Abbas, Hannah C Harris, Giles Major, Caroline Hoad, Penny Gowland, Luca Marciani, Samantha K Gill, Fred J Warren, Megan Rossi, Jose Maria Remes-Troche, Kevin Whelan, Robin C Spiller
OBJECTIVE: Health-promoting dietary fibre including inulin often triggers gastrointestinal symptoms in patients with IBS, limiting their intake. Our aim was to test if coadministering psyllium with inulin would reduce gas production. DESIGN: A randomised, four-period, four-treatment, placebo-controlled, crossover trial in 19 patients with IBS. Subjects ingested a 500 mL test drink containing either inulin 20 g, psyllium 20 g, inulin 20 g+ psyllium 20 g or dextrose 20 g (placebo)...
May 2022: Gut
#17
MULTICENTER STUDY
Sandra Mohr, Nikola Fritz, Christian Hammer, Cristina Martínez, Sabrina Berens, Stefanie Schmitteckert, Verena Wahl, Malin Schmidt, Lesley A Houghton, Miriam Goebel-Stengel, Maria Kabisch, Dorothea Götze, Irina Milovač, Mauro D'Amato, Tenghao Zheng, Ralph Röth, Hubert Mönnikes, Felicitas Engel, Annika Gauss, Jonas Tesarz, Martin Raithel, Viola Andresen, Thomas Frieling, Jutta Keller, Christian Pehl, Christoph Stein-Thöringer, Gerard Clarke, Paul J Kennedy, John F Cryan, Timothy G Dinan, Eamonn M M Quigley, Robin Spiller, Caroll Beltrán, Ana María Madrid, Verónica Torres, Edith Pérez de Arce, Wolfgang Herzog, Emeran A Mayer, Gregory Sayuk, Maria Gazouli, George Karamanolis, Lejla Kapur-Pojskič, Mariona Bustamante, Raquel Rabionet, Xavier Estivil, André Franke, Wolfgang Lieb, Guy Boeckxstaens, Mira M Wouters, Magnus Simrén, Gudrun A Rappold, Maria Vicario, Javier Santos, Rainer Schaefert, Justo Lorenzo-Bermejo, Beate Niesler
Irritable bowel syndrome (IBS) is a gut-brain disorder in which symptoms are shaped by serotonin acting centrally and peripherally. The serotonin transporter gene SLC6A4 has been implicated in IBS pathophysiology, but the underlying genetic mechanisms remain unclear. We sequenced the alternative P2 promoter driving intestinal SLC6A4 expression and identified single nucleotide polymorphisms (SNPs) that were associated with IBS in a discovery sample. Identified SNPs built different haplotypes, and the tagging SNP rs2020938 seems to associate with constipation-predominant IBS (IBS-C) in females...
August 2021: Journal of Cellular and Molecular Medicine
#18
JOURNAL ARTICLE
Hayfa Sharif, Caroline L Hoad, Nichola Abrehart, Penny A Gowland, Robin C Spiller, Sian Kirkham, Sabarinathan Loganathan, Michalis Papadopoulos, Marc A Benninga, David Devadason, Luca Marciani
BACKGROUND: Functional constipation in children is common. Management of this condition can be challenging and is often based on symptom reports. Increased, objective knowledge of colonic volume changes in constipation compared to health could provide additional information. However, very little data on paediatric colonic volume is available except from methods that are invasive or require unphysiological colonic preparations. OBJECTIVES: (1) To measure volumes of the undisturbed colon in children with functional constipation (FC) using magnetic resonance imaging (MRI) and provide initial normal range values for healthy controls, and (2) to investigate possible correlation of colonic volume with whole gut transit time (WGTT)...
May 28, 2021: Diagnostics
#19
JOURNAL ARTICLE
Jonna Jalanka, Ching Lam, Andrew Bennett, Anna Hartikainen, Fiona Crispie, Laura A Finnegan, Paul D Cotter, Robin Spiller
Background/Aims: Diarrhea-predominant irritable bowel syndrome (IBS-D) has been previously associated with evidence of immune activation and altered microbiota. Our aim is to assess the effect of the anti-inflammatory agent, mesalazine, on inflammatory gene expression and microbiota composition in IBS-D. Methods: We studied a subset of patients (n = 43) from a previously published 12-week radomized placebo-controlled trial of mesalazine. Mucosal biopsies were assessed by immunohistochemistry and reverse transcription-polymerase chain reaction for a range of markers of inflammation, altered permeability, and sensory receptors including Toll-like receptors (TLRs) at randomization after treatment...
April 30, 2021: Journal of Neurogastroenterology and Motility
#20
MULTICENTER STUDY
Vincent Cibert-Goton, Ching Lam, Melanie Lingaya, Yirga Falcone, John N Wood, David C Bulmer, Robin Spiller
INTRODUCTION: Despite heterogeneity, an increased prevalence of psychological comorbidity and an altered pronociceptive gut microenvironment have repeatedly emerged as causative pathophysiology in patients with irritable bowel syndrome (IBS). Our aim was to study these phenomena by comparing gut-related symptoms, psychological scores, and biopsy samples generated from a detailed diarrhea-predominant IBS patient (IBS-D) cohort before their entry into a previously reported clinical trial...
February 22, 2021: Clinical and Translational Gastroenterology
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