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Peritoneal sclerosis

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https://www.readbyqxmd.com/read/28153198/encapsulating-peritoneal-sclerosis
#1
REVIEW
Helen Alston, Stanley Fan, Masaaki Nakayama
Encapsulating peritoneal sclerosis (EPS) is a rare but serious complication of peritoneal dialysis. In this review, we describe the clinical picture and histologic changes to the peritoneal membrane that are associated with EPS and provide an update on current diagnosis and management. We also discuss the recent studies that have suggested that the use of more biocompatible solutions containing lower concentrations of glucose degradation product that often are pH neutral in combination with a change in clinical practice (reducing glucose exposure and monitoring peritoneal membrane function) might ameliorate peritoneal degeneration, reduce the incidence of EPS, and minimize the severity of the disease...
January 2017: Seminars in Nephrology
https://www.readbyqxmd.com/read/28110075/tlr9-mediated-regulatory-b10-cell-amplification-following-sub-total-body-irradiation-implications-in-attenuating-eae
#2
Jinsheng Hong, Jie Fang, Ruilong Lan, Qi Tan, Yeping Tian, Mei Zhang, Paul Okunieff, Lurong Zhang, Jianhua Lin, Deping Han
Autoimmunity and inflammation are controlled in part by regulatory B (Breg) cells, including the recently identified IL-10-competent B10 cell subset that represents 1%-3% of mouse spleen B cells. In this study, the influence of irradiation on Breg/B10 cell generation and IL-10 production mediated by TLR9 signaling pathways was investigated. Spleen and peritoneal cavity Breg/B10 cell frequencies were significantly expanded three weeks after sub-total body irradiation (sub-TBI, 5Gy or 10Gy) in adult male wild type (WT) C57BL/6(B6) mice but not in TLR9(-/-) mice...
March 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28012100/the-peritoneal-sieving-of-sodium-a-simple-and-powerful-test-to-rule-out-the-onset-of-encapsulating-peritoneal-sclerosis-in-patients-undergoing-peritoneal-dialysis
#3
Vincenzo La Milia, Selena Longhi, Elisabetta Sironi, Giuseppe Pontoriero
BACKGROUND AND AIMS: Encapsulating peritoneal sclerosis (EPS) is an uncommon but severe complication of peritoneal dialysis (PD). A reliable screening tool to identify patients at risk of developing or not EPS is currently not available. We aimed to evaluate whether the reduction in dialysate sodium concentration (sodium sieving) at 60 min (ΔDNa60), during a peritoneal equilibration test with 3.86% glucose concentration (3.86%-PET) was able to early rule out patients who will not develop EPS...
December 24, 2016: Journal of Nephrology
https://www.readbyqxmd.com/read/27997959/parthenolide-modulates-immune-response-in-cells-from-c57bl-6-mice-induced-with-experimental-autoimmune-encephalomyelitis
#4
Lara Soares Aleixo de Carvalho, Lívia Beatriz Almeida Fontes, Matheus Coutinho Gazolla, Débora Dos Santos Dias, Maria Aparecida Juliano, Gilson Costa Macedo, José Otávio do Amaral Corrêa, Ademar A Da Silva Filho
Multiple sclerosis is a chronic inflammatory and autoimmune disease of the central nervous system that affects more than 2.5 million people worldwide. Experimental autoimmune encephalomyelitis is a murine autoimmune disease used to study multiple sclerosis. Parthenolide, a natural sesquiterpene lactone found in Tanacetum parthenium L., is known for its strong anti-inflammatory activity. Herein, we have investigated the in vitro immunomodulatory effects of parthenolide on cytokine production and nitric oxide in cultured cells from myelin oligodendrocyte glycoprotein 35-55 amino acid peptide mice...
December 20, 2016: Planta Medica
https://www.readbyqxmd.com/read/27964725/the-enigma-of-primary-and-secondary-encapsulating-peritoneal-sclerosis
#5
Hisham Allam, Omer Al Yahri, Sharon Mathew, Adham Darweesh, Ahmed Nafea Suliman, Sherif Abdelaziem, Mohamed Khairat, Adriana Toro, Isidoro Di Carlo
BACKGROUND: Encapsulating Peritoneal Sclerosis (EPS) describes a variety of diseases that are frequently confused with different names and different etiopathogeneses. The aim of this article is to report personal experience of focusing on correct classification and the status of current diagnosis and treatment. METHODS: A retrospective analysis was performed. Age, sex, ethnic origin, past medical history, symptoms and their duration, radiological tools and signs, laboratory tests, preoperative diagnosis, surgical approach, intraoperative findings, pathological findings, hospital stay, morbidity and mortality were studied...
December 13, 2016: BMC Surgery
https://www.readbyqxmd.com/read/27942181/combined-surgical-and-immunosupressive-therapy-for-encapsulating-peritoneal-sclerosis
#6
P K Bipi, N Gracious, S Kumar, J George
Encapsulating peritoneal sclerosis (EPS) is an infrequent but serious complication of long-term peritoneal dialysis with 50% mortality and lack consensus on treatment. The pathogenesis of EPS is ill understood, and diagnosis lacks specificity and relies on clinical, radiographic and microscopic evaluation. Since there is no general agreement on managing EPS, we report a case treated successfully with surgery followed by immunosuppressive therapy with tamoxifen and steroids. He later successfully underwent deceased donor renal transplantation...
November 2016: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/27781116/case-report-of-a-patient-undergoing-peritoneal-dialysis-with-encapsulating-peritoneal-sclerosis-superimposed-with-calciphylaxis
#7
Jun Li Tsai, Ming Ju Wu, Cheng Hsu Chen, Shang Feng Tsai
INTRODUCTION: Encapsulating peritoneal sclerosis (EPS) is a rare but devastating complication of peritoneal dialysis (PD). Tamoxifen has been generally well-tolerated, even without randomized controlled trials. CASE PRESENTATION: Herein, we report a case of a patient undergoing 12 years of PD who developed EPS and calciphylaxis simultaneously. We also provide a comprehensive discussion about the association between EPS and calciphylaxis. Moreover, although tamoxifen is used in EPS due to its inhibition of fibroblast-transforming growth factor beta (TGFβ) production, it may worsen the calciphylaxis due to a hypercoagulable state...
August 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/27774831/risk-factors-of-severe-peritoneal-sclerosis-in-chronic-peritoneal-dialysis-patients
#8
Sudabeh Alatab, Iraj Najafi, Gholamreza Pourmand, Mostafa Hosseini, Soroosh Shekarchian
Peritoneal dialysis (PD) offers the healthiest way for starting renal replacement therapy (RRT) in End Stage Renal Disease patients, however exposes long-term PD patients to a dangerous complication named encapsulating peritoneal sclerosis (EPS). In this study, we searched for possible risk factors of EPS. Data were collected from two PD centers covering period 1995-2012 and comprised 464 patients. Control group defined as PD patients stayed on PD >42 month (n = 122), and case group was 12 confirmed EPS patients...
October 24, 2016: Renal Failure
https://www.readbyqxmd.com/read/27751625/paraneoplastic-systemic-sclerosis-about-3-cases-and-review-of-literature
#9
J-B Monfort, I Lazareth, P Priollet
OBJECTIVE: Association between cancer and systemic sclerosis (SSc) has been described. However, paraneoplastic SSc is not well known. The aim of this article is to describe cases of paraneoplastic systemic sclerosis and to compare them to other cases of the literature, to find characteristics that can make suspect a paraneoplastic mechanism when SSc is diagnosed. METHODS: We retrospectively analyzed patients, in our department who, over the last 15 years, presented with Raynaud's phenomenon with a diagnosis of SSc (including cancer during the period of SSc)...
December 2016: Journal des Maladies Vasculaires
https://www.readbyqxmd.com/read/27723234/a-combination-of-corticosteroid-sirolimus-and-intradialytic-parenteral-nutrition-in-encapsulating-peritoneal-sclerosis-case-report-and-literature-review
#10
REVIEW
Alexandre Minetto Brabo, Nayrana Soares Do Carmo Reis, Pasqual Barretti, Daniela Ponce
Encapsulating peritoneal sclerosis (EPS) is a rare complication of peritoneal dialysis that carries a high morbidity and mortality. Although its pathogenesis is still not clear, the "two hit theory" suggests that long term deterioration of the peritoneum combined with intraperitoneal inflammation is needed in the pathogenesis of EPS. To date, there is no proven effective therapy with an absence of randomized controlled trials. Individual case reports and small case series have reported on the use of tamoxifen and corticosteroids for medical management of EPS...
October 9, 2016: Hemodialysis International
https://www.readbyqxmd.com/read/27721224/a-new-experience-with-encapsulating-peritoneal-sclerosis-role-of-early-intervention
#11
Tahere Sadat Kalantarian, Iraj Najafi
After 20 years of peritoneal dialysis in Iran, we have encountered with several cases of encapsulating peritoneal sclerosis (EPS) in past few years. Many of these cases remained undiagnosed until advanced stages due to lack of suspicion. In centers with more experience about EPS, mortality has decreased by early diagnostic interventions. Peritoneal dialysis nurses may not be aware of EPS and radiologists are usually not familiar with EPS, either. To increase knowledge about this condition, we decided to present this review article with the case study of one of the 1st patients with EPS at our center...
September 2016: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/27659928/percutaneous-endoscopic-gastrostomy-with-jejunal-extension-for-an-encapsulating-peritoneal-sclerosis-refractory-to-surgical-enterolysis
#12
Masataka Banshodani, Hideki Kawanishi, Misaki Moriishi, Sadanori Shintaku, Shinji Hashimoto, Shinichiro Tsuchiya
Surgical enterolysis is the final option for patients with encapsulating peritoneal sclerosis (EPS). However, EPS is sometimes refractory to surgical enterolysis. This is the first report of successful use of percutaneous endoscopic gastrostomy with jejunal extension (PEG-J) in a patient with EPS that was refractory to surgical enterolysis. We propose that sustained drainage of digestive juices by PEG-J, along with central venous nourishment at home, can be a treatment option for patients with EPS that cannot be treated with radical measures...
September 2016: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/27651961/pneumatosis-cystoides-intestinalis-in-patients-with-systemic-sclerosis-a-case-report-and-review-of-39-japanese-cases
#13
Manabu Kaneko, Shin Sasaki, Shuzo Teruya, Kosuke Ozaki, Kazuhiro Ishimaru, Emi Terai, Hiroshi Nakayama, Toshiyuki Watanabe
Pneumatosis cystoides intestinalis (PCI) is a rare gastrointestinal complication of systemic sclerosis (SSc) characterized by intramural accumulation of gas within thin-walled cysts. We report the case of an 82-year-old female patient with pneumoperitoneum due to PCI associated with SSc and review the features of the 39 Japanese cases. The median patient age was 57 years (range 24-83 years) and the male/female ratio was 1 : 12. In the recent decade, 14 out of 15 cases (93.3%) evaluated with CT scans were diagnosed with PCI...
2016: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/27628605/a-case-of-encapsulating-peritoneal-sclerosis-complicated-by-malignant-peritoneal-mesothelioma
#14
Genta Kanai, Takatoshi Kakuta, Takashi Hirukawa, Chizuko Okamatsu, Masafumi Fukagawa
We report a case of peritoneal mesothelioma discovered in a patient during peritoneal dialysis. The patient was a 55-year-old woman who had no history of asbestos exposure. Owing to end-stage kidney failure, she had been undergoing peritoneal dialysis for over 8 years, and she had been diagnosed with encapsulating peritoneal sclerosis. She was admitted to the hospital for intestinal obstruction. Three months later, she noticed an enlarging mass in the epigastric region. Computed tomography showed a 10-cm mass originating in the abdominal wall that had invaded the liver...
September 20, 2016: Tokai Journal of Experimental and Clinical Medicine
https://www.readbyqxmd.com/read/27596540/surgical-management-of-complications-with-peritoneal-dialysis
#15
REVIEW
Andrzej Ratajczak, Małgorzata Lange-Ratajczak, Adam Bobkiewicz, Adam Studniarek
This report reviews the most common surgical interventions and complications of chronic peritoneal dialysis (PD) patients. Based on the current knowledge as well as our experience we detail the role of these surgical procedures. We supplement the reported knowledge in the field with our own experience in this area. The areas discussed include early complications such as surgical wound hemorrhage, bleeding from the catheter, intestinal perforation and urinary bladder perforation, dialysate leakage through the wound, as well as late complications including catheter kinking or occlusion, retention of fluid in the peritoneal recess, hernias and hydrothorax, and encapsulating peritoneal sclerosis...
January 2017: Seminars in Dialysis
https://www.readbyqxmd.com/read/27559700/fty720-induced-lymphopenia-does-not-aggravate-mortality-in-a-murine-model-of-polymicrobial-abdominal-sepsis
#16
Jana Enderes, Julia van der Linde, Jan Müller, Bich-Thu Tran, Wolfram von Bernstorff, Claus-Dieter Heidecke, Tobias Schulze
BACKGROUND: FTY720 is an immunosuppressive molecule licensed for the treatment of chronic relapsing multiple sclerosis (MS). It attenuates the adaptive immune response by sequestering T cells within secondary lymphoid organs via its action as functional antagonist of sphingosine-1-phasphate. To date, it is unknown whether FTY-induced lymphopenia puts MS patients at increased risk for severe forms of postoperative infectious complications such as abdominal sepsis. OBJECTIVES: To determine the effect of FTY720-induced lymphopenia on survival to sepsis secondary to postoperative intraabdominal infections in a murine model of polymicrobial sepsis...
March 2017: Shock
https://www.readbyqxmd.com/read/27556577/risk-factors-for-encapsulating-peritoneal-sclerosis-analysis-of-a-36-year-experience-in-a-university-hospital
#17
Masatsugu Nakao, Izumi Yamamoto, Yukio Maruyama, Masamitsu Morishita, Akio Nakashima, Nanae Matsuo, Yudo Tanno, Ichiro Ohkido, Masato Ikeda, Hiroyasu Yamamoto, Keitaro Yokoyama, Takashi Yokoo
AIM: Encapsulating peritoneal sclerosis (EPS) is a rare but serious complication that occurs in peritoneal dialysis (PD) therapy. The present study aimed to identify the risk factors, especially peritonitis and biocompatible PD fluid. METHODS: The study included 703 patients who received PD between January 1980 and March 2015 at two centers. The patients were divided into two groups: those who had developed EPS (EPS group: n = 44) and those who had no documentary evidence of EPS (non-EPS group: n = 659)...
August 24, 2016: Nephrology
https://www.readbyqxmd.com/read/27540308/the-number-of-patients-with-severe-encapsulating-peritoneal-sclerosis-is-decreasing-in-a-large-referral-center-in-germany
#18
Daniel Kitterer, Niko Braun, M Dominik Alscher, Stephan Segerer, Joerg Latus
BACKGROUND: Encapsulating peritoneal sclerosis (EPS) is the most severe complication associated with long-term peritoneal dialysis (PD). Previous studies noticed a sharp decline in new patients with severe EPS. We investigated the number of severe EPS patients in our large referral center over almost 20 years. METHODS: All late-stage EPS patients who underwent major surgery due to extensive symptoms caused by bowel obstruction (vomiting, abdominal pain, and weight loss) between March 1997 and end of December 2015 in our hospital were included in the present study...
2016: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/27525063/the-interplay-between-microbiota-and-inflammation-lessons-from-peritonitis-and-sepsis
#19
REVIEW
Leandro A Lobo, Claudia F Benjamim, Ana Carolina Oliveira
Mammals harbor a complex gut-associated microbiota, comprising bacteria that provide immunological, metabolic and neurological benefits to the host, and contribute to their well-being. However, dysregulation of the microbiota composition, known as dysbiosis, along with the associated mucosal immune response have a key role in the pathogenesis of many inflammatory diseases, including inflammatory bowel diseases (IBDs), type 1 and type 2 diabetes, asthma, multiple sclerosis, among others. In addition, outside the gut lumen, bacteria from microbiota are the causative agent of peritoneal inflammation, abdominal sepsis and systemic sepsis...
July 2016: Clinical & Translational Immunology
https://www.readbyqxmd.com/read/27478609/incidence-and-outcome-of-encapsulating-peritoneal-sclerosis
#20
Michaela C Petrie, Jamie P Traynor, Robert A Mactier
BACKGROUND: Studies report variation in the incidence and outcomes of encapsulating peritoneal sclerosis (EPS). This study reports the incidence and outcome of EPS cases in a national cohort of peritoneal dialysis (PD) patients. METHODS: The incident cohort of adult patients who started PD between 1 January 2000 and 31 December 2007 in Scotland (n = 1238) was identified from the Scottish Renal Registry. All renal units in Scotland identified potential EPS cases diagnosed from 1 January 2000 to 31 December 2014, by which point all patients had a minimum of 7 years follow-up from start of PD...
August 2016: Clinical Kidney Journal
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