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Peritoneal sclerosis

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https://www.readbyqxmd.com/read/28676511/absence-of-post-transplantation-encapsulating-peritoneal-sclerosis-after-relatively-short-exposure-to-peritoneal-dialysis-prospective-analysis-using-repeated-abdominal-ct-scanning
#1
Alferso C Abrahams, Maaike K van Gelder, Jan Willem van der Veer, Pim A de Jong, Maarten S van Leeuwen, Walther H Boer
BACKGROUND: Encapsulating peritoneal sclerosis (EPS) is the most severe complication of peritoneal dialysis (PD). Several retrospective reports published between 2007 and 2009 have suggested an increasing incidence of EPS occurring after kidney transplantation. We conducted a prospective observational study to determine the incidence of post-transplantation EPS and identify possible risk factors. METHODS: Consecutive PD patients undergoing kidney transplantation between 2009 and 2013 were included...
July 2017: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/28676508/the-potential-cardiovascular-benefits-of-low-glucose-degradation-product-biocompatible-peritoneal-dialysis-fluids-a-review-of-the-literature
#2
REVIEW
Charlotte E Grantham, Katherine L Hull, Matthew P M Graham-Brown, Daniel S March, James O Burton
Cardiovascular mortality in the end-stage renal disease (ESRD) population remains the leading cause of death. Targeting traditional cardiovascular risk factors has proven unsuccessful in this patient population, and therefore attention has turned to risk factors related to chronic kidney disease (CKD). The toxicity of high-glucose peritoneal dialysis (PD) solutions has been well documented. The breakdown of glucose into glucose degradation products (GDP) and advanced glycation end-products (AGE) has the ability to alter cell viability and cause premature apoptosis and is strongly correlated with interstitial fibrosis and microvascular sclerosis...
July 2017: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/28676507/length-of-time-on-peritoneal-dialysis-and-encapsulating-peritoneal-sclerosis-position-paper-for-ispd-2017-update
#3
Edwina A Brown, Joanne Bargman, Wim van Biesen, Ming-Yang Chang, Frederic O Finkelstein, Helen Hurst, David W Johnson, Hideki Kawanishi, Mark Lambie, Thyago Proença de Moraes, Johann Morelle, Graham Woodrow
No abstract text is available yet for this article.
July 2017: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/28674469/pharmaceutical-approval-update
#4
Mary Choy
Niraparib (Zejula) for recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer; ocrelizumab (Ocrevus) for relapsing or primary progressive multiple sclerosis; and dupilumab (Dupixent) for moderate-to-severe atopic dermatitis.
July 2017: P & T: a Peer-reviewed Journal for Formulary Management
https://www.readbyqxmd.com/read/28673451/a-prospective-proteomics-study-identified-potential-biomarkers-of-encapsulating-peritoneal-sclerosis-in-peritoneal-effluent
#5
Vasileios Zavvos, Anthony T Buxton, Caroline Evans, Mark Lambie, Simon J Davies, Nicholas Topley, Martin Wilkie, Angela Summers, Paul Brenchley, Dimitrios S Goumenos, Timothy S Johnson
Encapsulating peritoneal sclerosis (EPS) is a potentially devastating complication of peritoneal dialysis (PD). Diagnosis is often delayed due to the lack of effective and accurate diagnostic tools. We therefore examined peritoneal effluent for potential biomarkers that could predict or confirm the diagnosis of EPS and would be valuable in stratifying at-risk patients and driving appropriate interventions. Using prospectively collected samples from the Global Fluid Study and a cohort of Greek PD patients, we utilized 2D SDSPAGE/ MS and iTRAQ to identify changes in the peritoneal effluent proteome from patients diagnosed with EPS and controls matched for treatment exposure...
July 1, 2017: Kidney International
https://www.readbyqxmd.com/read/28667272/adiponectin-is-an-endogenous-anti-fibrotic-mediator-and-therapeutic-target
#6
Roberta G Marangoni, Yuri Masui, Feng Fang, Benjamin Korman, Gabriel Lord, Junghwa Lee, Katja Lakota, Jun Wei, Philipp E Scherer, Laszlo Otvos, Toshimasa Yamauchi, Naoto Kubota, Takashi Kadowaki, Yoshihide Asano, Shinichi Sato, Warren G Tourtellotte, John Varga
Skin fibrosis in systemic sclerosis (SSc) is accompanied by attrition of dermal white adipose tissue (dWAT) and reduced levels of circulating adiponectin. Since adiponectin has potent regulatory effects on fibroblasts, we sought to assess adiponectin signaling in SSc skin biopsies, and evaluate fibrosis in mice with adiponectin gain- and loss-of-function mutations. Furthermore, we investigated the effects and mechanism of action of agonist peptides targeting adiponectin receptors in vitro and in vivo. We found that adiponectin pathway activity was significantly reduced in a subset of SSc skin biopsies...
June 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28653946/the-truth-on-current-peritoneal-dialysis-state-of-the-art
#7
R T Krediet, A C Abrahams, C W H de Fijter, M G H Betjes, W H Boer, B C van Jaarsveld, C J A M Konings, F W Dekker
The share of peritoneal dialysis (PD) in the spectrum of chronic dialysis has decreased markedly in the Netherlands in the last 15 years. Consequently, the knowledge of nephrologists and nursing staff on PD has declined leading to a negative spiral in which loss of experience resulted in loss of enthusiasm to offer PD to patients and also in less interest in the new PD developments. All these changes took place while the results of PD improved and patient survival was at least similar to that on haemodialysis...
June 2017: Netherlands Journal of Medicine
https://www.readbyqxmd.com/read/28576435/-encapsulating-peritoneal-sclerosis
#8
Jean-Philippe Ryckelynck, Clémence Béchade, Nicolas Bouvier, Maxence Ficheux, Bruno Hurault de Ligny, Thierry Lobbedez
Encapsulating peritoneal sclerosis is a rare but devastating complication of long-term peritoneal dialysis with a high mortality rate. The incidence is between 0.5 and 2.5%, decreasing with time. PSE is defined as a clinical syndrome with signs of gastrointestinal obstruction, inflammation parameters, radiological and macroscopic changes. The duration of treatment and the cessation of peritoneal dialysis are the main risks. About 75% occured in patients on hemodialysis or after kidney transplantation. Morphological alterations are disappearance of mesothelial layer, submesothelial fibrosis, interstitial sclerosis and vasculopathy...
May 30, 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/28551820/cd147-expression-in-peritoneal-injury
#9
Harald Seeger, Joerg Latus, Daniel Kitterer, M Dominik Alscher, Dagmar Biegger, Jin Chen, Ilka Edenhofer, Rudolf P Wüthrich, Stephan Segerer
BACKGROUND: Peritoneal injury is an important cause of technical failure of long-term peritoneal dialysis (PD). Encapsulating peritoneal sclerosis (EPS) is a severe complication of long-term PD with potentially life threatening consequences. CD147 is a glycoprotein with diverse functions including modulation of extracellular matrix via induction of matrix metalloproteinases, cell adhesion, and regulation of immune reactions. We hypothesized that CD 147 plays a role in the peritoneal cavity...
May 27, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28507181/fli1-deficiency-induces-cxcl6-expression-in-dermal-fibroblasts-and-endothelial-cells-contributing-to-the-development-of-fibrosis-and-vasculopathy-in-systemic-sclerosis
#10
Takashi Taniguchi, Yoshihide Asano, Kouki Nakamura, Takashi Yamashita, Ryosuke Saigusa, Yohei Ichimura, Takehiro Takahashi, Tetsuo Toyama, Ayumi Yoshizaki, Shinichi Sato
OBJECTIVE: CXCL6, a chemokine with proangiogenic property, is reported to be involved in vasculopathy associated with systemic sclerosis (SSc). We investigated the contribution of CXCL6 to SSc development by focusing on the association of friend leukemia virus integration 1 (Fli1) deficiency, a potential predisposing factor of SSc, with CXCL6 expression and clinical correlation of serum CXCL6 levels. METHODS: mRNA levels of target genes and the binding of Fli1 to the CXCL6 promoter were evaluated by quantitative reverse transcription-PCR and chromatin immunoprecipitation, respectively...
May 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28414753/sustained-low-peritoneal-effluent-ccl18-levels-are-associated-with-preservation-of-peritoneal-membrane-function-in-peritoneal-dialysis
#11
Marta Ossorio, María Auxiliadora Bajo, Gloria Del Peso, Virginia Martínez, María Fernández, María José Castro, Aranzazu Rodríguez-Sanz, Rosario Madero, Teresa Bellón, Rafael Selgas
Peritoneal membrane failure (PMF) and, ultimately, encapsulating peritoneal sclerosis (EPS) are the most serious peritoneal dialysis (PD) complications. Combining clinical and peritoneal transport data with the measurement of molecular biomarkers, such as the chemokine CCL18, would improve the complex diagnosis and management of PMF. We measured CCL18 levels in 43 patients' effluent and serum at baseline and after 1, 2, and 3 years of PD treatment by retrospective longitudinal study, and evaluated their association with PMF/EPS development and peritoneal risk factors...
2017: PloS One
https://www.readbyqxmd.com/read/28393968/-encapsulating-peritoneal-sclerosis
#12
Rubén Torres, Paula Ebner, María Eugenia Sanhueza, Miriam Alvo, Erico Segovia, Paula Segura
BACKGROUND: Encapsulating peritoneal sclerosis (EPS) is a complication of peritoneal dialysis (PD) with a low prevalence but high mortality. It is characterized by peritoneal inflammation and fibrosis with subsequent development of intestinal encapsulation. It is associated with a long lapse on PD, frequent episodes of peritonitis, high glucose solution use, and high peritoneal transport status. AIM: To report the clinical features of patients on PD, who developed EPS...
January 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28360369/significant-decreasing-incidence-of-encapsulating-peritoneal-sclerosis-in-the-dutch-population-of-peritoneal-dialysis-patients
#13
Michiel G H Betjes, Sayed M Habib, Els W Boeschoten, Aline C Hemke, Dick G Struijk, Ralph Westerhuis, Alferso C Abrahams, Mario R Korte
The Dutch Encapsulating Peritoneal Sclerosis (EPS) Registry was started in 2009. Cases were identified by contacting all Dutch nephrologists twice yearly. The predefined criteria for EPS allowed for inclusion of patients with diagnosed and suspected EPS. Cases registered between January 2009 and January 2015 were analyzed with follow-up until September 2015. Fifty-three EPS cases were identified, of which 28.3% were post-transplantation EPS cases. Fourteen patients were initially categorized as suspected EPS, of whom 13 developed EPS...
March 2017: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/28289671/encapsulating-peritoneal-sclerosis-in-liver-transplant-recipients-a-report-of-2-cases
#14
Kyo Won Lee, Chan Woo Cho, Nuri Lee, Sanghoon Lee, Jong Man Kim, Gyu-Seong Choi, Choon Hyuck David Kwon, Jae-Won Joh, Suk-Koo Lee
Encapsulating peritoneal sclerosis (EPS) is a rare cause of intestinal obstruction by a thick fibrous membrane wrapping around the small intestine. It is a possible complication after liver transplantation (LT) that can be fatal. This report describes 2 cases of EPS after LT that were successfully treated with surgery, corticosteroids, tamoxifen, and mammalian target of rapamycin inhibitor. After treatment in both cases, the patients were able to start oral feeding and have been symptom free for more than 1 year...
March 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/28153198/encapsulating-peritoneal-sclerosis
#15
REVIEW
Helen Alston, Stanley Fan, Masaaki Nakayama
Encapsulating peritoneal sclerosis (EPS) is a rare but serious complication of peritoneal dialysis. In this review, we describe the clinical picture and histologic changes to the peritoneal membrane that are associated with EPS and provide an update on current diagnosis and management. We also discuss the recent studies that have suggested that the use of more biocompatible solutions containing lower concentrations of glucose degradation product that often are pH neutral in combination with a change in clinical practice (reducing glucose exposure and monitoring peritoneal membrane function) might ameliorate peritoneal degeneration, reduce the incidence of EPS, and minimize the severity of the disease...
January 2017: Seminars in Nephrology
https://www.readbyqxmd.com/read/28110075/tlr9-mediated-regulatory-b10-cell-amplification-following-sub-total-body-irradiation-implications-in-attenuating-eae
#16
Jinsheng Hong, Jie Fang, Ruilong Lan, Qi Tan, Yeping Tian, Mei Zhang, Paul Okunieff, Lurong Zhang, Jianhua Lin, Deping Han
Autoimmunity and inflammation are controlled in part by regulatory B (Breg) cells, including the recently identified IL-10-competent B10 cell subset that represents 1%-3% of mouse spleen B cells. In this study, the influence of irradiation on Breg/B10 cell generation and IL-10 production mediated by TLR9 signaling pathways was investigated. Spleen and peritoneal cavity Breg/B10 cell frequencies were significantly expanded three weeks after sub-total body irradiation (sub-TBI, 5Gy or 10Gy) in adult male wild type (WT) C57BL/6(B6) mice but not in TLR9(-/-) mice...
March 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28012100/the-peritoneal-sieving-of-sodium-a-simple-and-powerful-test-to-rule-out-the-onset-of-encapsulating-peritoneal-sclerosis-in-patients-undergoing-peritoneal-dialysis
#17
Vincenzo La Milia, Selena Longhi, Elisabetta Sironi, Giuseppe Pontoriero
BACKGROUND AND AIMS: Encapsulating peritoneal sclerosis (EPS) is an uncommon but severe complication of peritoneal dialysis (PD). A reliable screening tool to identify patients at risk of developing or not EPS is currently not available. We aimed to evaluate whether the reduction in dialysate sodium concentration (sodium sieving) at 60 min (ΔDNa60), during a peritoneal equilibration test with 3.86% glucose concentration (3.86%-PET) was able to early rule out patients who will not develop EPS...
December 24, 2016: Journal of Nephrology
https://www.readbyqxmd.com/read/27997959/parthenolide-modulates-immune-response-in-cells-from-c57bl-6-mice-induced-with-experimental-autoimmune-encephalomyelitis
#18
Lara Soares Aleixo de Carvalho, Lívia Beatriz Almeida Fontes, Matheus Coutinho Gazolla, Débora Dos Santos Dias, Maria Aparecida Juliano, Gilson Costa Macedo, José Otávio do Amaral Corrêa, Ademar A Da Silva Filho
Multiple sclerosis is a chronic inflammatory and autoimmune disease of the central nervous system that affects more than 2.5 million people worldwide. Experimental autoimmune encephalomyelitis is a murine autoimmune disease used to study multiple sclerosis. Parthenolide, a natural sesquiterpene lactone found in Tanacetum parthenium L., is known for its strong anti-inflammatory activity. Herein, we have investigated the in vitro immunomodulatory effects of parthenolide on cytokine production and nitric oxide in cultured cells from myelin oligodendrocyte glycoprotein 35-55 amino acid peptide mice...
May 2017: Planta Medica
https://www.readbyqxmd.com/read/27964725/the-enigma-of-primary-and-secondary-encapsulating-peritoneal-sclerosis
#19
Hisham Allam, Omer Al Yahri, Sharon Mathew, Adham Darweesh, Ahmed Nafea Suliman, Sherif Abdelaziem, Mohamed Khairat, Adriana Toro, Isidoro Di Carlo
BACKGROUND: Encapsulating Peritoneal Sclerosis (EPS) describes a variety of diseases that are frequently confused with different names and different etiopathogeneses. The aim of this article is to report personal experience of focusing on correct classification and the status of current diagnosis and treatment. METHODS: A retrospective analysis was performed. Age, sex, ethnic origin, past medical history, symptoms and their duration, radiological tools and signs, laboratory tests, preoperative diagnosis, surgical approach, intraoperative findings, pathological findings, hospital stay, morbidity and mortality were studied...
December 13, 2016: BMC Surgery
https://www.readbyqxmd.com/read/27942181/combined-surgical-and-immunosupressive-therapy-for-encapsulating-peritoneal-sclerosis
#20
P K Bipi, N Gracious, S Kumar, J George
Encapsulating peritoneal sclerosis (EPS) is an infrequent but serious complication of long-term peritoneal dialysis with 50% mortality and lack consensus on treatment. The pathogenesis of EPS is ill understood, and diagnosis lacks specificity and relies on clinical, radiographic and microscopic evaluation. Since there is no general agreement on managing EPS, we report a case treated successfully with surgery followed by immunosuppressive therapy with tamoxifen and steroids. He later successfully underwent deceased donor renal transplantation...
November 2016: Indian Journal of Nephrology
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