Zhouyang Li, Yinfang Wu, Haipin Chen, Chen Zhu, Lingling Dong, Yong Wang, Huiwen Liu, Xuchen Xu, Jiesen Zhou, Yanping Wu, Wen Li, Songmin Ying, Huahao Shen, Zhihua Chen
Increasing toxicological and epidemiological studies have demonstrated that ambient particulate matter (PM) could cause adverse health effects including inflammation in the lung. Alveolar macrophages represent a major type of innate immune responses to foreign substances. However, the detailed mechanisms of inflammatory responses induced by PM exposure in macrophages are still unclear. We observed that coarse PM treatment rapidly activated mechanistic target of rapamycin (MTOR) in mouse alveolar macrophages in vivo, and in cultured mouse bone marrow-derived macrophages, mouse peritoneal macrophages, and RAW264...
March 21, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists