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lymphocytes and diabetes type 2

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https://www.readbyqxmd.com/read/29409002/ptpn22-and-ctla-4-polymorphisms-are-associated-with-polyglandular-autoimmunity
#1
Juliane Houcken, Christina Degenhart, Klaus Bender, Jochem König, Lara Frommer, George J Kahaly
Context: Single nucleotide polymorphisms (SNP) of various genes increase susceptibility to monoglandular autoimmunity. Scarce data are available in autoimmune polyglandular syndromes (APS). Objective: Evaluate potential associations of eight SNP with APS. Setting: Academic referral endocrine clinic. Patients: A total of 543 patients with APS, monoglandular autoimmunity and controls. Intervention: The SNP protein tyrosine phosphatase non-receptor type 22 (PTPN22) rs2476601 (+1858), cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) rs3087243 (CT60) and rs231775 (AG49), Vitamin D Receptor (VDR) rs1544410 (Bsm I), rs7975232 (Apa I), rs731236 (Taq I), tumor necrosis factor alpha rs1800630 (-863) and Interleukin-2 receptor alpha rs10795791 were tested by single base extension in all subjects...
February 1, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29375842/visceral-leishmaniasis-in-a-patient-with-diabetes-mellitus-type-2-and-discrete-bicytopenia
#2
Verena Schwetz, Christian Trummer, Claudia Friedl, Christine Beham-Schmid, Roman Kulnik, Albert Wölfler, Karl Horvath, Stefanie Wunsch, Jürgen Prattes, Ines Zollner-Schwetz, Thomas R Pieber, Julia K Mader, Robert Krause
An Austrian patient with diabetes mellitus type 2 developed visceral leishmaniasis after trips to Spain and Crete, presenting with slight bicytopenia, later developing severe pancytopenia. Travel history taking is important due to an extended incubation period. Coexistence of diabetes mellitus can impair T lymphocyte function and cause higher relapse rates.
January 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29351188/proangiogenic-effect-of-metformin-in-endothelial-cells-is-via-upregulation-of-vegfr1-2-and-their-signaling-under-hyperglycemia-hypoxia
#3
Sherin Bakhashab, Farid Ahmed, Hans-Juergen Schulten, Fahad W Ahmed, Michael Glanville, Mohammed H Al-Qahtani, Jolanta U Weaver
Cardiovascular disease is the leading cause of morbidity/mortality worldwide. Metformin is the first therapy offering cardioprotection in type 2 diabetes and non-diabetic animals with unknown mechanism. We have shown that metformin improves angiogenesis via affecting expression of growth factors/angiogenic inhibitors in CD34⁺ cells under hyperglycemia-hypoxia. Now we studied the direct effect of physiological dose of metformin on human umbilical vein endothelial cells (HUVEC) under conditions mimicking hypoxia-hyperglycemia...
January 19, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29329700/-a-listeria-breast-abscess-in-a-man
#4
E Marsaudon, J Berthy, S Mamoune, A Deniel, S Ksiyer, D Tiuca
INTRODUCTION: Listeriosis is a food-borne illness leading to bacteriemia or central nervous system infection especially in pregnant women or high-risk patients. It is rarely a localized infection. Breast contamination has rarely been reported in lactating women. We report a breast abscess in man. CASE REPORT: A 80 year old man, hypertensive and arrhythmic, was explored for weakness and dehydration. Type 2 diabetes and chronic lymphocytic leukemia were diagnosed...
January 9, 2018: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29317328/investigation-of-in-vitro-genotoxic-effects-of-an-anti-diabetic-drug-sitagliptin
#5
Deniz Yuzbasioglu, Cemile Enguzel-Alperen, Fatma Unal
Sitagliptin is an active ingredient of antidiabetic drug used in the treatment of type 2 diabetes mellitus (T2DM). In this study, the genotoxic effects of sitagliptin were determined in human lymphocytes by using chromosome aberrations (CAs), sister chromatid exchanges (SCEs), micronucleus (MN) and comet assays. 31.25-1000 μg/mL concentrations of sitagliptin were used. Sitagliptin significantly increased the frequency of CAs and SCEs at the highest concentration at 24 h treatment and all concentrations (except 250 μg/mL for CA, except 31...
January 6, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29289901/established-and-suggested-exposures-on-cll-sll-etiology-results-from-the-cll-mcc-spain-study
#6
Yolanda Benavente, Delphine Casabonne, Laura Costas, Claudia Robles, Esther Alonso, Esmeralda de la Banda, Eva Gonzalez-Barca, Rafael Marcos-Gragera, Javier Llorca, Adonina Tardón, José J Monleon, Marta Aymerich, Elías Campo, Eva Gimeno-Vázquez, Gemma Castaño-Vinyals, Nuria Aragonés, Marina Pollán, Manolis Kogevinas, Sílvia de Sanjosé
INTRODUCTION: Chronic Lymphocytic Leukemia (CLL/SLL) is the most common adult leukemia in Western countries. Although it is mostly an indolent disease it is still incurable and with limited knowledge in relation to its etiology. We aim to confirm and quantify established risk factors for CLL/SLL using a multi-center epidemiological population-based case-control study on CLL/SLL as well as to explore new exposures inconclusively associated with CLL/SLL METHODS: Using the framework provided by the large MCC-Spain case-control study, we explored established and suggested risk factors associated with CLL/SLL using data collected through a face-to-face interview...
February 2018: Cancer Epidemiology
https://www.readbyqxmd.com/read/29285450/neutrophil-lymphocyte-ratio-is-a-novel-reliable-predictor-of-nephropathy-retinopathy-and-coronary-artery-disease-in-indians-with-type-2-diabetes
#7
Sachin Chittawar, Deep Dutta, Zahran Qureshi, Vineet Surana, Sagar Khandare, Tribhuvan Nath Dubey
Background and Aims: Neutrophil-lymphocyte ratio (NLR) has been suggested to be a predictor of coronary artery disease (CAD), and end-organ damage in type-2 diabetes mellitus (T2DM). Similar data are lacking from Indians with T2DM. Hence, this study aimed to evaluate the role of NLR as a predictor of microvascular complications and CAD in T2DM. Subjects and Methods: Consecutive T2DM patients attending the outpatient services of 2 different hospitals, who gave consent, underwent clinical, anthropometric evaluation, and evaluation for the occurrence of retinopathy, nephropathy, neuropathy, and CAD...
November 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29285097/mir-34a-and-mir-125b-are-upregulated-in-peripheral-blood-mononuclear-cells-from-patients-with-type-2-diabetes-mellitus
#8
Yanxin Shen, Huiling Xu, Xiaoyuan Pan, Weijiang Wu, Hui Wang, Linlin Yan, Miaomiao Zhang, Xia Liu, Sheng Xia, Qixiang Shao
Type 2 diabetes mellitus (T2DM) is a leading cause of blindness, non-traumatic amputation and end-stage renal disease, as well as a major cardiovascular risk factor. To determine whether miR-125b and miR-34a serve an important role in the development of T2DM, the current study investigated the expression profile of two microRNAs (miR-34a and miR-125b) and their relative genes in peripheral blood mononuclear cells from 73 patients with T2DM and 52 healthy donors by reverse transcription-quantitative polymerase chain reaction In addition, the association between miR-34a, miR-125b and their relevant genes expression profile were analyzed with respect to the pathogenesis of T2DM...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29259496/immunosenescence-in-aging-between-immune-cells-depletion-and-cytokines-up-regulation
#9
REVIEW
Maria Teresa Ventura, Marco Casciaro, Sebastiano Gangemi, Rosalba Buquicchio
Background: The immunosenescence is a relatively recent chapter, correlated with the linear extension of the average life began in the nineteenth century and still in progress. The most important feature of immunosenescence is the accumulation in the "immunological space" of memory and effector cells as a result of the stimulation caused by repeated clinical and subclinical infections and by continuous exposure to antigens (inhalant allergens, food, etc.). This state of chronic inflammation that characterizes senescence has a significant impact on survival and fragility...
2017: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/29259102/altered-homeostasis-and-development-of-regulatory-t-cell-subsets-represent-an-il-2r-dependent-risk-for-diabetes-in-nod-mice
#10
Connor J Dwyer, Allison L Bayer, Carmen Fotino, Liping Yu, Cecilia Cabello-Kindelan, Natasha C Ward, Kevin H Toomer, Zhibin Chen, Thomas R Malek
The cytokine interleukin-2 (IL-2) is critical for the functions of regulatory T cells (Tregs). The contribution of polymorphisms in the gene encoding the IL-2 receptor α subunit (IL2RA), which are associated with type 1 diabetes, is difficult to determine because autoimmunity depends on variations in multiple genes, where the contribution of any one gene product is small. We investigated the mechanisms whereby a modest reduction in IL-2R signaling selectively in T lymphocytes influenced the development of diabetes in the NOD mouse model...
December 19, 2017: Science Signaling
https://www.readbyqxmd.com/read/29193677/gallic-acid-a-common-dietary-phenolic-improves-health-associated-biochemical-parameters-and-prevents-oxidative-damage-of-dna-in-type-2-diabetes-patients-results-of-a-placebo-controlled-pilot-study
#11
Franziska Ferk, Michael Kundi, Helmut Brath, Thomas Szekeres, Halh Al-Serori, Miroslav Mišík, Philipp Saiko, Rodrig Marculescu, Karl-Heinz Wagner, Siegfried Knasmueller
SCOPE: Oxidative imbalance plays a key role in cancer induction and cardiovascular diseases (CVD) in patients with type 2 diabetes mellitus (T2DM). The aim of this study was to find out if gallic acid (GA) prevents oxidative stress in diabetic patients. Therefore, we investigated its impact on oxidation of DNA bases and on other health-related macromolecules. METHODS AND RESULTS: We performed an intervention study (n = 19) with GA and monitored alterations of the DNA stability in single cell gel electrophoresis (SCGE) assays in lymphocytes...
November 28, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29189047/combined-serum-free-light-chain-levels-are-associated-with-carotid-atherosclerosis-in-type-2-diabetes-mellitus
#12
Felix Aberer, Norbert Joachim Tripolt, Hubert Scharnagl, Julian Zedler, Michaela Eder, Abderrahim Oulhaj, Tatjana Stojakovic, Harald Sourij
BACKGROUND: Patients with type 2 diabetes mellitus face an increased risk of cardiovascular events compared to non-diabetic counterparts. Chronic inflammation and activation of the immune system, including B-lymphocyte maturation is believed to play a role in atherosclerosis. Recent investigations suggest combined serum free light chains as a potential biomarker for cardiovascular events. The aim of this analysis was to investigate the association of combined serum free light chain with carotid atherosclerosis in subjects with type 2 diabetes mellitus...
November 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29137012/the-relationship-between-neutrophil-to-lymphocyte-ratio-and-diabetic-peripheral-neuropathy-in-type-2-diabetes-mellitus
#13
Tingting Xu, Zihua Weng, Chu Pei, Siyuan Yu, Yating Chen, Wenjie Guo, Xingzuo Wang, Peng Luo, Jia Sun
To explore the relationship between neutrophil-to-lymphocyte ratio (NLR) and diabetic peripheral neuropathy (DPN) in type 2 diabetes mellitus.A total of 557 newly diagnosed Type 2 Diabetes Mellitus (T2DM) patients were recruited, including 397 T2DM patients without complication (DM group) as well as 160 T2DM patients complicated with DPN (DPN group). Student t test, Mann-Whitney U test, or χ test was applied to the data of the 2 groups, including the levels of neutrophils and lymphocytes as well as the NLR values of peripheral blood and other biochemistry indexes; Pearson correlation analysis was used to calculate the correlation of NLR and detected factors; risk factors of DPN were estimated via logistic regression analysis and multivariate analysis...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29125137/red-blood-cell-distribution-width-relative-lymphocyte-count-and-type-2-diabetes-mellitus-predict-all-cause-mortality-in-patients-with-advanced-heart-failure
#14
Bożena Szyguła-Jurkiewicz, Łukasz Siedlecki, Łukasz Pyka, Ewa Romuk, Piotr Przybyłowski, Mariusz Gąsior
INTRODUCTION    Early identification of patients with advanced heart failure (HF) who are at a higher risk for poor outcome is an important element of patient management, both from the medical and the economic point of view. OBJECTIVES    In the present study, we sought to determine the association between hematologic parameters assessed on admission and within the 3-year mortality period in patients consecutively admitted with advanced HF.  We also investigated the association between baseline demographic and clinical data and mortality...
November 9, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/29073286/differential-adipokine-receptor-expression-on-circulating-leukocyte-subsets-in-lean-and-obese-children
#15
Genoveva Keustermans, Laila B van der Heijden, Berlinda Boer, Rianne Scholman, Roos Nuboer, Gerard Pasterkamp, Berent Prakken, Wilco de Jager, Eric Kalkhoven, Arieke J Janse, Henk S Schipper
BACKGROUND: Childhood obesity prevalence has increased worldwide and is an important risk factor for type 2 diabetes (T2D) and cardiovascular disease (CVD). The production of inflammatory adipokines by obese adipose tissue contributes to the development of T2D and CVD. While levels of circulating adipokines such as adiponectin and leptin have been established in obese children and adults, the expression of adiponectin and leptin receptors on circulating immune cells can modulate adipokine signalling, but has not been studied so far...
2017: PloS One
https://www.readbyqxmd.com/read/29070459/-neutrophil-to-lymphocyte-ratio-as-a-predictor-for-type-2-diabetes-mellitus-in-patients-with-chronic-obstructive-pulmonary-disease-a-cohort-study-of-404-cases
#16
Tao Ye, Yin Yang, Kai Wang, Mei Wang, Jia Sun, Yue DU, Xin Chen
OBJECTIVE: To assess the value of neutrophil?to?lymphocyte ratio (NLR) for predicting type 2 diabetes mellitus (T2DM) in patients with chronic obstructive pulmonary disease (COPD). METHODS: A cohort of 404 non?diabetic patients diagnosed with stable COPD between January, 2010 and December, 2012 at Zhujiang Hospital were enrolled and followed up for 3 years, during which fast blood glucose (FBG) was monitored every 6 months. The primary endpoint was the occurrence of T2DM, and the cumulative incidence of T2DM in this cohort was calculated...
October 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28992267/white-blood-cell-fractions-correlate-with-lesions-of-diabetic-kidney-disease-and-predict-loss-of-kidney-function-in-type-2-diabetes
#17
Kevin M Wheelock, Pierre-Jean Saulnier, Stephanie K Tanamas, Pavithra Vijayakumar, E Jennifer Weil, Helen C Looker, Robert L Hanson, Kevin V Lemley, Berne Yee, William C Knowler, Samy Hadjadj, Bezhad Najafian, Michael Mauer, Robert G Nelson
Background: Inflammation linked to diabetic kidney disease (DKD) may affect white blood cell (WBC) counts and differentials. We examined the cross-sectional associations of total WBC count and WBC fractions with structural lesions of DKD in 108 Pima Indians with Type 2 diabetes who underwent research kidney biopsies. We also examined the longitudinal association of these WBC variables with renal function loss (RFL) in 941 Europeans with Type 2 diabetes from the SURDIAGENE study. Methods: Associations of WBC variables with morphometric parameters were assessed by linear regression...
July 18, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28988715/self-transducible-bimodal-pdx1-foxp3-protein-lifts-insulin-secretion-and-curbs-autoimmunity-boosting-tregs-in-type-1-diabetic-mice
#18
Christina Amatya, Ilian A Radichev, Jacob Ellefson, Mark Williams, Alexei Y Savinov
Type 1 diabetes (T1D) is characterized by massive destruction of insulin-producing β cells by autoreactive T lymphocytes, arising via defective immune tolerance. Therefore, effective anti-T1D therapeutics should combine autoimmunity-preventing and insulin production-restoring properties. We constructed a cell-permeable PDX1-FOXP3-TAT fusion protein (FP) composed of two transcription factors: forkhead box P3 (FOXP3), the master regulator of differentiation and functioning of self-tolerance-promoting Tregs, and pancreatic duodenal homeobox-1 (PDX1), the crucial factor supporting β cell development and maintenance...
September 7, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28986401/activation-of-cd4-and-cd8-t-lymphocytes-by-insulin-and-gad-in-patients-with-type-1-or-2-diabetes-mellitus
#19
Borros Arneth
BACKGROUND: The origin of autoimmune disease type 1 diabetes is still unknown. AIM: This study assessed the activation of CD4+ and CD8+ T-lymphocytes by human insulin and human glutamate decarboxylase (GAD) in patients with type 1 or type 2 diabetes mellitus (DM) and healthy volunteers. MATERIALS AND METHODS: The expression of CD69, a marker of T-lymphocyte activity, was determined in whole blood samples by flow cytometry after 12 h of incubation with or without insulin or GAD...
November 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28983603/inflammatory-and-oxidative-stress%C3%A2-associated-factors-in-chronic-intermittent-hypoxia-in-chinese-patients-rats-lymphocytes-and-endotheliocytes
#20
Hui Ren, Ke Hu
In order to investigate the association between inflammatory and oxidative stress (OS)‑associated factors in chronic intermittent hypoxia (CIH), 238 CIH patients and 156 healthy volunteers were included. CIH rat and lymphocytes were used as experimental models. Interleukin (IL)‑6, tumor necrosis factor‑α (TNF‑α), C‑reactive protein (CRP), nitric oxide (NO) and nitric oxide synthase (NOS) were analyzed. Patients with CIH were older, with hypertension, increased heart rate (HR) and body mass index (BMI), and there were more males than females...
December 2017: Molecular Medicine Reports
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