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https://www.readbyqxmd.com/read/28808216/modeling-and-validating-three-dimensional-human-normal-cervix-and-cervical-cancer-tissues-in-vitro
#1
Anna Karolina Zuk, Xuesong Wen, Stephen Dilworth, Dong Li, Lucy Ghali
The use of three dimensional in vitro systems in cancer research is a promising path for developing effective anticancer therapies. The aim of this study was to engineer a functional 3-Din vitro model of normal and cancerous cervical tissue.Normal epithelial and immortalized cervical epithelial carcinoma cell lines were used to construct 3-D artificial normal cervical and cervical cancerous tissues. De-epidermised dermis (DED) was used as a scaffold for both models. Morphological analyses were conducted by using hematoxylin and eosin staining and characteristics of the models were studied by analyzing the expression of different structural cytokeratins and differential protein marker Mad1 using immunohistochemical technique...
January 19, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/28755871/cyclohexene-fused-1-3-oxazines-with-selective-antibacterial-and-antiparasitic-action-and-low-cytotoxic-effects
#2
Maria R M de Brito, Walter J Peláez, Martín S Faillace, Gardenia C G Militão, Jackson R G S Almeida, Gustavo A Argüello, Zsolt Szakonyi, Ferenc Fülöp, Maria C Salvadori, Fernanda S Teixeira, Rivelilson M Freitas, Pedro L S Pinto, Ana C Mengarda, Marcos P N Silva, Ademar A Da Silva Filho, Josué de Moraes
Oxazine derivatives, a class of heterocyclic compounds, exhibit a variety of biological properties, such as anticonvulsant and antitumor activities. In this study, we evaluated the effect of two cyclohexene-fused 1,3-oxazines (cis‑1-benzyl-N-phenyl-1,4,4a,5,8,8a-hexahydro-3,1-benzoxazin-2-imine (1) and trans‑N-phenyl-1,4,4a,5,8,8a-hexahydro-3,1-benzoxazin-2-imine (2)) in cultures of Bacillus cereus, Enterococcus faecalis, Escherichia coli, Klebsiella pneumoniae, Salmonella enterica, Serratia marcescens, Shigella flexneri and Staphylococcus aureus by the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC)...
July 26, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28753926/the-prostaglandin-ep3-receptor-is-an-independent-negative-prognostic-factor-for-cervical-cancer-patients
#3
Helene Heidegger, Sebastian Dietlmeier, Yao Ye, Christina Kuhn, Aurelia Vattai, Caroline Aberl, Udo Jeschke, Sven Mahner, Bernd Kost
We know that one of the main risk factors for cervical cancer is an infection with high-risk human papillomavirus (HR-HPV). Prostaglandins and their receptors are very important for the tumour growth and tumour-associated angiogenesis. Little is known about the expression of the Prostaglandin E receptor type 3 (EP3) or the Prostaglandin (PG)E₂-EP3 signalling in cervical cancer, so the aim of the study was to analyse the expression of the EP3 receptor in cervical cancer and find prognostic factors in relation to survival; EP3 immunohistological staining of 250 cervical cancer slides was performed and analysed with a semi-quantitative score...
July 19, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28670843/poorly-differentiated-vaginal-adenocarcinoma-with-aggressive-behavior-pap-smear-findings
#4
José Eleutério, Francisca Margalene Medeiros de Freitas, Denise Nunes Oliveira, David Freitas Moreira, Mirley Sângela Pessoa
Vaginal carcinoma is a rare condition. In this report, we describe a case of a poorly differentiated aggressive adenocarcinoma in a woman with a three month history of vaginal bleeding and a negative Pap smear done six months prior to her consultation. Specular examination showed a normal cervix, but there was a bleeding ulcer (2 cm in diameter) in the upper third of the vagina. Cytology revealed poorly differentiated atypical cells, and the biopsy established a diagnosis of vaginal adenocarcinoma with little differentiation...
July 3, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28629213/la-sopravvivenza-dei-pazienti-oncologici-in-italia
#5
Vincenzo Coviello, Carlotta Buzzoni, Mario Fusco, Alessandro Barchielli, Francesco Cuccaro, Roberta De Angelis, Adriano Giacomin, Stefano Luminari, Giorgia Randi, Lucia Mangone
OBJECTIVES: Population-based survival statistics are fundamental to assess the efficacy of services offered to improve cancer patients' prognosis. This study aims to update cancer survival estimates for the Italian population, as well as provide new measures, such as the crude probability of death, which takes into account the possibility of dying from causes other than cancer, and the change in life expectancy after a cancer diagnosis, to properly address various questions. RESULTS: The study includes 1,932,450 cancer cases detected by the Network of Italian Cancer Registries (AIRTUM) from 1994 to 2011 and provides estimates for 38 cancer sites and for allsites cancer...
March 2017: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/28614543/cytopathologic-evaluation-of-patients-submitted-to-radiotherapy-for-uterine-cervix-cancer
#6
Cátia Martins Leite Padilha, Mário Lúcio Cordeiro Araújo, Sergio Augusto Lopes de Souza
Cervical cancer is an important public health problem. Pap smear is the leading strategy of screening programs for cervical cancer worldwide. However, delayed diagnosis leads to more aggressive and less effective treatments. Patients with uterine cervix malignancies who are referred for radiotherapy have advanced-stage disease, which results in high rates of locoregional recurrence. The use of radiotherapy as a treatment for cervical cancer causes morphological changes in neoplastic and non-neoplastic epithelial cells, as well as in stromal cells, which make it difficult to diagnose the residual lesion, resulting in a dilemma in cytopathological routine...
April 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28599153/effects-of-repeated-biaxial-loads-on-the-creep-properties-of-cardinal-ligaments
#7
Adwoa Baah-Dwomoh, Raffaella De Vita
The cardinal ligament (CL) is one of the major pelvic ligaments providing structural support to the vagina/cervix/uterus complex. This ligament has been studied mainly with regards to its important function in the treatment of different diseases such as surgical repair for pelvic organ prolapse and radical hysterectomy for cervical cancer. However, the mechanical properties of the CL have not been fully determined, despite the important in vivo supportive role of this ligament within the pelvic floor. To advance our limited knowledge about the elastic and viscoelastic properties of the CL, we conducted three consecutive planar equi-biaxial tests on CL specimens isolated from swine...
May 31, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28576184/radiation-oncology-management-of-stage-i-iii-cervix-cancer
#8
REVIEW
Lana de Souza Lawrence
Radiotherapy plays a critical role in the management of cervix carcinoma, in the adjuvant setting for patients with high-risk pathologic features and in the definitive setting for locoregionally advanced disease. External beam radiotherapy fields encompass potential areas of microscopic disease spread in addition to known areas of gross disease. In the presence of gross disease, however, escalation of dose is required that is best accomplished using a brachytherapy boost to spare surrounding normal organs from toxicity...
July 2017: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/28574604/boosting-the-snr-by-adding-a-receive-only-endorectal-monopole-to-an-external-antenna-array-for-high-resolution-t2-weighted-imaging-of-early-stage-cervical-cancer-with-7-t-mri
#9
I M L van Kalleveen, J P Hoogendam, A J E Raaijmakers, F Visser, C S Arteaga de Castro, R H M Verheijen, P R Luijten, R P Zweemer, W B Veldhuis, D W J Klomp
The aim of this study was to investigate the signal-to-noise ratio (SNR) gain in early-stage cervical cancer at ultrahigh-field MRI (e.g. 7 T) using a combination of multiple external antennas and a single endorectal antenna. In particular, we used an endorectal monopole antenna to increase the SNR in cervical magnetic resonance imaging (MRI). This should allow high-resolution, T2 -weighted imaging and magnetic resonance spectroscopy (MRS) for metabolic staging, which could facilitate the local tumor status assessment...
September 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28560854/pharmacogenetic-analysis-of-irreversible-severe-cisplatin-induced-nephropathy-a-case-report-of-a-27-year-old-woman
#10
Corine de Jong, Stefan Sanders, Geert-Jan Creemers, Artur M Burylo, Margot Taks, Jan H M Schellens, Maarten J Deenen
In this report we describe a young patient diagnosed with bulky FIGO stage IIIb squamous cell cervix carcinoma with severe and irreversible nephropathy after three weekly low-doses of cisplatin. Besides several known risk factors such as hypomagnesemia and hypoalbuminemia, the patient also proved to be homozygously polymorphic for two polymorphisms within the COMT gene (c.615 + 310C>T and c.616-367C>T). As COMT polymorphism has been associated with cisplatin-induced ototoxicity, its effect on nephrotoxicity of cisplatin should be the subject of further investigation...
September 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28448799/isolation-of-antioxidant-phenolics-from-schinopsis-brasiliensis-based-on-a-preliminary-lc-ms-profiling
#11
Clisiane Carla de Souza Santos, Milena Masullo, Antonietta Cerulli, Angela Mari, Charles Dos Santos Estevam, Cosimo Pizza, Sonia Piacente
The phenolic content of the ethanol extract of the stem bark of the Brazilian plant Schinopsis brasiliensis Engl. (Anacardiaceae) has been evaluated together with the antioxidant activity. The good antioxidant activity exhibited in the Trolox Equivalent Antioxidant Capacity (TEAC) assay (TEAC value = 3.04 mg/mL) encouraged us to investigate its constituents. An analytical approach based on LC-ESIMS(n) was applied to rapidly obtain a metabolite profile of the ethanol extract of the stem bark of S. brasiliensis...
August 2017: Phytochemistry
https://www.readbyqxmd.com/read/28447562/dosimetric-advantages-of-a-clinical-daily-adaptive-plan-selection-strategy-compared-with-a-non-adaptive-strategy-in-cervical-cancer-radiation-therapy
#12
Agustinus J A J van de Schoot, Peter de Boer, Jorrit Visser, Lukas J A Stalpers, Coen R N Rasch, Arjan Bel
BACKGROUND: Radiation therapy (RT) using a daily plan selection adaptive strategy can be applied to account for interfraction organ motion while limiting organ at risk dose. The aim of this study was to quantify the dosimetric consequences of daily plan selection compared with non-adaptive RT in cervical cancer. MATERIAL AND METHODS: Ten consecutive patients who received pelvic irradiation, planning CTs (full and empty bladder), weekly post-fraction CTs and pre-fraction CBCTs were included...
May 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28421163/phase-i-trial-of-triapine-cisplatin-paclitaxel-chemotherapy-for-advanced-stage-or-metastatic-solid-tumor-cancers
#13
Charles A Kunos, Edward Chu, Della Makower, Andreas Kaubisch, Mario Sznol, Susan Percy Ivy
Ribonucleotide reductase (RNR) is an enzyme involved in the de novo synthesis of deoxyribonucleotides, which are critical for DNA replication and DNA repair. Triapine is a small-molecule RNR inhibitor. A phase I trial studied the safety of triapine in combination with cisplatin-paclitaxel in patients with advanced stage or metastatic solid tumor cancers in an effort to capitalize on disrupted DNA damage repair. A total of 13 patients with various previously treated cancers were given a 96-h continuous intravenous (i...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28404551/endocervical-gastric-type-adenocarcinoma-an-unrelated-hpv-tumour-difficulties-in-screening-and-diagnosis
#14
Priscila Carneiro Lima, Julio Teixeira, Guilherme Nogueira Aires, Liliana De Angelo Andrade
Gastric-type adenocarcinoma of the cervix (GAS) is an uncommon and aggressive tumour unrelated to human papillomavirus (HPV) infection with distinctive histological and immunohistochemical characteristics. GAS may be associated with lobular endocervical glandular hyperplasia (LEGH), another unusual lesion. We report a case of a 59-year-old woman with screening cytology 'AGC-Neo' and cervical conisation exhibiting cervical intraepithelial neoplasia grade 1, extensive LEGH and canal sampling with abundant mucinous cells...
April 11, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28400857/estimation-of-the-overall-burden-of-cancers-precancerous-lesions-and-genital-warts-attributable-to-9-valent-hpv-vaccine-types-in-women-and-men-in-europe
#15
Susanne Hartwig, Jean Lacau St Guily, Géraldine Dominiak-Felden, Laia Alemany, Silvia de Sanjosé
BACKGROUND: In addition to cervical cancer, human papillomavirus (HPV) is responsible for a significant proportion of cancers and precancerous lesions of the vulva, vagina, anus, penis, head and neck, as well as genital warts. We estimated the annual number of new cases of these diseases attributable to 9-valent HPV vaccine types in women and men in Europe. METHODS: The annual number of new cancers of the cervix, vulva, vagina, anus, penis, and selected head and neck sites in the population of the European Medicines Agency territory was estimated based on age-specific incidence rates extracted from Cancer Incidence in 5 Continents, Volume X and Eurostat population data for 2015...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28369882/worldwide-burden-of-cancer-attributable-to-hpv-by-site-country-and-hpv-type
#16
Catherine de Martel, Martyn Plummer, Jerome Vignat, Silvia Franceschi
HPV is the cause of almost all cervical cancer and is responsible for a substantial fraction of other anogenital cancers and oropharyngeal cancers. Understanding the HPV-attributable cancer burden can boost programs of HPV vaccination and HPV-based cervical screening. Attributable fractions (AFs) and the relative contributions of different HPV types were derived from published studies reporting on the prevalence of transforming HPV infection in cancer tissue. Maps of age-standardized incidence rates of HPV-attributable cancers by country from GLOBOCAN 2012 data are shown separately for the cervix, other anogenital tract and head and neck cancers...
August 15, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28365229/the-role-of-interleukin-10-in-human-papilloma-virus-infection-and-progression-to-cervical-carcinoma
#17
REVIEW
Fernanda Costa Brandão Berti, Ana Paula Lombardi Pereira, Guilherme Cesar Martelossi Cebinelli, Kleber Paiva Trugilo, Karen Brajão de Oliveira
Although Human Papillomavirus (HPV) exerts a vital influence on cervical carcinogenesis, other factors influence the development of a squamous intraepithelial lesion (SIL) that may or not progress to cervical cancer. Among several cytokines, Interleukin 10 (IL-10) stands out as an important anti-inflammatory factor, leading to immune system evasion through an immunosuppressive state. In the cervical microenvironment, during different stages of HPV infection, IL-10 production can be induced and maintained by different cell sources, including infected keratinocytes, some subsets of dendritic cells (DC), tumor associated macrophages (TAM), T regulatory cells (Treg) and tumor cells...
March 23, 2017: Cytokine & Growth Factor Reviews
https://www.readbyqxmd.com/read/28362190/hpv-epigenetic-mechanisms-related-to-oropharyngeal-and-cervix-cancers
#18
Marina Di Domenico, Giancarlo Giovane, Soumaya Kouidhi, Rosamaria Iorio, Maurizio Romano, Francesco De Francesco, Antonia Feola, Camilla Siciliano, Luigi Califano, Antonio Giordano
Human Papilloma Virus infection is very frequent in humans and is mainly transmitted sexually. The majority of infections are transient and asymptomatic, however, if the infection persists, it can occur with a variety of injuries to skin and mucous membranes, depending on the type of HPV involved. Some types of HPV are classified as high oncogenic risk as associated with the onset of cancer. The tumors most commonly associated with HPV are cervical and oropharyngeal cancer, epigenetic mechanisms related to HPV infection include methylation changes to host and viral DNA and chromatin modification in host species...
March 31, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28102052/increasing-incidence-of-invasive-and-in-situ-cervical-adenocarcinoma-in-the-netherlands-during-2004-2013
#19
Judith van der Horst, Albert G Siebers, Johan Bulten, Leon F Massuger, Inge McM de Kok
In the developed world, the incidence of cervical squamous cell carcinoma has decreased, however, the incidence of adenocarcinoma in situ (AIS) and invasive adenocarcinoma increased, predominantly in young females. The goal of this study was to evaluate the most recent incidence rates of AIS, adenocarcinoma, and squamous cell carcinoma of the uterine cervix in the Netherlands in 2004-2013. By using Dutch national pathology and cancer registries, we calculated European standardized incidence rates (ESR) and estimated annual percentage changes (EAPC) for AIS during 2004-2013 and for invasive cervical carcinomas during 1989-2013...
February 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28047139/we-de-201-02-a-statistical-analysis-tool-for-plan-quality-verification-in-hdr-brachytherapy-forward-planning-for-cervix-cancer
#20
R Ma, X Zhu, S Li, D Zheng, Y Lei, S Wang, V Verma, N Bennion, A Wahl, S Zhou
PURPOSE: High Dose Rate (HDR) brachytherapy forward planning is principally an iterative process; hence, plan quality is affected by planners' experiences and limited planning time. Thus, this may lead to sporadic errors and inconsistencies in planning. A statistical tool based on previous approved clinical treatment plans would help to maintain the consistency of planning quality and improve the efficiency of second checking. METHODS: An independent dose calculation tool was developed from commercial software...
June 2016: Medical Physics
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