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https://www.readbyqxmd.com/read/28433444/risk-of-ocular-hypertension-in-adults-with-noninfectious-uveitis
#1
Ebenezer Daniel, Maxwell Pistilli, Srishti Kothari, Naira Khachatryan, R Oktay Kaçmaz, Sapna S Gangaputra, H Nida Sen, Eric B Suhler, Jennifer E Thorne, C Stephen Foster, Douglas A Jabs, Robert B Nussenblatt, James T Rosenbaum, Grace A Levy-Clarke, Nirali P Bhatt, John H Kempen
PURPOSE: To describe the risk and risk factors for ocular hypertension (OHT) in adults with noninfectious uveitis. DESIGN: Retrospective, multicenter, cohort study. PARTICIPANTS: Patients aged ≥18 years with noninfectious uveitis seen between 1979 and 2007 at 5 tertiary uveitis clinics. METHODS: Demographic, ocular, and treatment data were extracted from medical records of uveitis cases. MAIN OUTCOME MEASURES: Prevalent and incident OHT with intraocular pressures (IOPs) of ≥21 mmHg, ≥30 mmHg, and increase of ≥10 mmHg from documented IOP recordings (or use of treatment for OHT)...
April 19, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28429670/expression-of-dominant-negative-k6w-ubiquitin-in-the-lens-epithelium-via-an-adenoviral-vector-delays-posterior-capsule-opacification-in-a-rabbit-model
#2
Xuan Bao, Min Hou, Ruiping Peng, Furong Luo, Mingxing Wu
PURPOSE: Ubiquitin is involved in cell proliferation and differentiation, and the objective of this study is to investigate the potential of dominant negative Ubiquitin (Ub) with a lysine to tryptophan mutation at the 6 position (K6W) through an adenoviral expression vector in the prevention of posterior capsule opacification (PCO) in a rabbit PCO model. METHODS: Recombinant dominant negative K6W-Ub adenovirus (RAd-K6W-Ub) with green fluorescent protein (RAd-K6W-Ub/GFP) and RAd-GFP viruses (control) were generated with QBI-HEK 293A cells...
March 31, 2017: Current Molecular Medicine
https://www.readbyqxmd.com/read/28429294/ocular-cubosome-drug-delivery-system-for-timolol-maleate-preparation-characterization-cytotoxicity-ex-vivo-and-in-vivo-evaluation
#3
Jiayuan Huang, Tingting Peng, Yanrong Li, Zhengwen Zhan, Youmei Zeng, Ying Huang, Xin Pan, Chuan-Yu Wu, Chuanbin Wu
Glaucoma is an ocular disease featuring increased intraocular pressure (IOP) and its primary treatment strategy is to lower IOP by medication. Current ocular drug delivery in treating glaucoma is confronting a variety of challenges, such as low corneal permeability and bioavailability due to the unique anatomical structure of the human eye. To tackle these challenges, a cubosome drug delivery system for glaucoma treatment was constructed for timolol maleate (TM) in this study. The TM cubosomes (liquid crystalline nanoparticles) were prepared using glycerol monooleate and poloxamer 407 via high-pressure homogenization...
April 20, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28428227/mechanisms-in-endocrinology-the-multiple-facets-of-gh-lessons-from-lifetime-untreated-isolated-gh-deficiency-due-to-ghrh-receptor-mutation
#4
Manuel Aguiar-Oliveira, Anita Ho Souza, Carla R Oliveira, Viviane C Campos, Luiz A Oliveira-Neto, Roberto Salvatori
Twenty years ago, we described a kindred of 105 individuals with isolated GH deficiency (IGHD) in Itabaianinha County, in Brazilian northeast, due to a homozygous mutation in the GH-releasing hormone receptor gene. These subjects exhibit markedly reduced GH responsiveness to stimulatory tests, and anterior pituitary hypoplasia. Serum concentrations of IGF-I, IGF binding protein type 3, and the acid-labile subunit are markedly reduced, with a lesser reduction of IGF-II. The most striking physical findings of these IGHD individuals are the proportionate short stature, doll facies, high-pitched voice, and visceral obesity with reduced fat free mass...
April 20, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28421664/intermediate-and-long-term-outcome-of-piggyback-drainage-connecting-glaucoma-drainage-device-to-a-device-in-situ-for-improved-intraocular-pressure-control
#5
Edward Dervan, Edward Lee, Antonio Giubilato, Tina Khanam, Panayiotis Maghsoudlou, William H Morgan
IMPORTANCE: This study provides results of a treatment option for patients with failed primary glaucoma drainage device BACKGROUND: To describe and evaluate the long term intraocular pressure (IOP) control and complications of a new technique joining a second glaucoma drainage device (GDD) directly to an existing GDD: termed "piggyback drainage". DESIGN: A retrospective, interventional cohort study PARTICIPANTS: 18 eyes of 17 patients who underwent piggyback drainage between 2004 and 2013 inclusive...
April 19, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28417337/descemet-stripping-automated-endothelial-keratoplasty-versus-descemet-membrane-endothelial-keratoplasty-a-meta-analysis
#6
REVIEW
Leru Zhu, Yi Zha, Jianqiu Cai, Yanling Zhang
PURPOSE: To evaluate the efficacy and safety of descemet stripping automated endothelial keratoplasty (DSAEK) compared with descemet membrane endothelial keratoplasty (DMEK). METHODS: Databases including PubMed, EMBASE, and Cochrane Library were searched to find studies that compared DSAEK and DMEK outcomes. Efficacy parameters were the postoperative best-corrected visual acuity (BCVA) and spherical equivalent (SE). Safety parameters were postoperative endothelial cell loss (ECL), air injection (rebubbling), graft failure, graft rejection, and high intraocular pressure (IOP)...
April 17, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28410723/risk-factors-predicting-steroid-induced-ocular-hypertension-after-photorefractive-keratectomy
#7
Yumna Busool, Michael Mimouni, Igor Vainer, Shmuel Levartovsky, Tzahi Sela, Gur Munzer, Igor Kaiserman
PURPOSE: To assess the risk factors contributing to steroid-induced ocular hypertension after photorefractive keratectomy (PRK). SETTING: Care Laser Centers, Tel Aviv, Israel. DESIGN: Retrospective case series. METHODS: Patients having PRK between January 2000 and December 2015 were followed for at least 3 months. Intraocular pressure (IOP) was measured using the Goldmann applanation tonometer after 1 week and after 1, 3, and 6 months...
March 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28405756/-maculopathy-with-optic-nerve-pits-morphological-criteria-in-sd%C3%AF-%C3%AF-oct
#8
K Wehrmann, S Stumpfe, M Pettenkofer, N Feucht, C Lohmann, M Maier
PURPOSE: Optic pit is a congenital anomaly with malformation similar to coloboma of the optic disc. The cause of optic pit maculopathy is controversial. We used high resolution OCT to investigate changes in the vitreoretinal and vitreopapillary transition within optic pit eyes. METHODS: The vitreoretinal and vitreo-papillary transition of 12 eyes was accurately analyzed using SD-OCT. We registered the following criteria: liquefaction of prepapillary vitreous, papillary vitreous traction, discontinuity within the hyaloid cortex and communication spaces between pit and retinal edema...
April 12, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28405481/factors-affecting-contrast-sensitivity-in-healthy-individuals-a-pilot-study
#9
Arzu Seyhan Karatepe, Süheyla Köse, Sait Eğrilmez
OBJECTIVES: To determine the demographic and ocular features affecting contrast sensitivity levels in healthy individuals. MATERIALS AND METHODS: Seventy-four eyes of 37 subjects (7-65 years old) with refractive errors less than 1.0 diopter, no history of ocular surgery, and 20/20 visual acuity were included in the study. The participants were divided by age into three groups: group 1, 7-19 years, n=11; group 2, 20-49 years, n=15; and group 3, 50-65 years, n=11...
April 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28400560/tgf-%C3%AE-induces-phosphorylation-of-phosphatase-and-tensin-homolog-implications-for-fibrosis-of-the-trabecular-meshwork-tissue-in-glaucoma
#10
Nikoleta Tellios, Jillian C Belrose, Alexander C Tokarewicz, Cindy Hutnik, Hong Liu, Andrew Leask, Michael Motolko, Miho Iijima, Sunil K Parapuram
Fundamental cell signaling mechanisms that regulate dynamic remodeling of the extracellular matrix (ECM) in mechanically loaded tissues are not yet clearly understood. Trabecular meshwork (TM) tissue in the eye is under constant mechanical stress and continuous remodeling of ECM is crucial to maintain normal aqueous humor drainage and intraocular pressure (IOP). However, excessive ECM remodeling can cause fibrosis of the TM as in primary open-angle glaucoma (POAG) patients, and is characterized by increased resistance to aqueous humor drainage, elevated IOP, optic nerve degeneration and blindness...
April 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28397310/creatine-supplementation-reduces-sleep-need-and-homeostatic-sleep-pressure-in-rats
#11
Markus Dworak, Tae Kim, Robert W Mccarley, Radhika Basheer
Sleep has been postulated to promote brain energy restoration. It is as yet unknown if increasing the energy availability within the brain reduces sleep need. The guanidine amino acid creatine (Cr) is a well-known energy booster in cellular energy homeostasis. Oral Cr-monohydrate supplementation (CS) increases exercise performance and has been shown to have substantial effects on cognitive performance, neuroprotection and circadian rhythms. The effect of CS on cellular high-energy molecules and sleep-wake behaviour is unclear...
April 11, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28387762/age-related-macular-degeneration-in-a-south-indian-population-with-and-without-diabetes
#12
S Srinivasan, G Swaminathan, V Kulothungan, S Ganesan, T Sharma, R Raman
PurposeTo elucidate the prevalence and risk factors of age-related macular degeneration (AMD) in people with diabetes.MethodsOf the 5495 subjects ≥60 years of age recruited in the population-based study in south India, 4791 subjects with gradable images on 30° three-field retinal photographs were analyzed. AMD and diabetic retinopathy (DR) were graded based on the International ARM Epidemiological Study Group classification and International Clinical Diabetic Retinopathy Disease Severity Scale, respectively...
April 7, 2017: Eye
https://www.readbyqxmd.com/read/28377591/a-safety-study-of-high-concentration-and-high-frequency-intravitreal-injection-of-conbercept-in-rabbits
#13
Jiaming Wang, Chunyan Lei, Lifei Tao, Quan Wu, Xiao Ke, Yiguo Qiu, Bo Lei
The novel anti-VEGF drug conbercept has been used in the treatment of several retinal neovascular diseases. Owning to the alteration of the structure, the newest drug is capable of combining more molecular targets and present higher affinity to the angiogenesis promoting factors. However, it is unknown whether it will cause any unwanted effects like other anti-VEGF agents. We studied the short-term safety of high concentration and high frequency intravitreal injection of conbercept in rabbits. Intraocular pressure, fundus-photography, ERGs were applied...
April 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28376677/lens-opacities-in-children-using-methylphenidate-hydrochloride
#14
Nagihan Saday Duman, Rahmi Duman, Emel Sarı Gökten, Reşat Duman
PURPOSE: To assess clinical findings of eye examination in children who is taking methylphenidate hydrochloride with Attention Deficit Hyperactivity Disorder. METHODS: Fifty seven consecutive patients who were diagnosed of Attention Deficit Hyperactivity Disorder (ADHD) and have been under oral methylphenidate hydrochloride treatment for at least one year were involved in this study (Group 1). Sixty healthy subjects (Group 2) who have similar demographic features compared with the group 1, were involved as a control group...
April 4, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28376091/participant-referral-rate-in-the-national-eye-health-survey-nehs
#15
Stuart Keel, Pei Ying Lee, Joshua Foreman, Peter van Wijngaarden, Hugh R Taylor, Mohamed Dirani
PURPOSE: To present the rates of referral of participants in the National Eye Health Survey (NEHS) for further eye care. MATERIALS & METHODS: A national sample of 3098 non-Indigenous Australians aged 50-98 and 1738 Indigenous Australians aged 40-92 years living in 30 randomly selected sites was recruited using a door-to-door approach. Participants completed a general questionnaire and a series of eye tests, including vision and anterior segment assessment, intra-ocular pressure measurement, visual field testing and fundus photography...
2017: PloS One
https://www.readbyqxmd.com/read/28367193/prevalence-and-causes-of-visual-impairment-among-saudi-adults
#16
Mujeeb Ur Rehman Parrey, Farhan Khashim Alswelmi
OBJECTIVE: To evaluate the prevalence and causes of visual impairment (VI) among Saudi adults in Arar City, the capital of Northern Border Region of Saudi Arabia. METHODS: This population-based cross-sectional study was conducted on 705 Saudi adults aged 18 years and older. All participants underwent ophthalmic examination including visual acuity (VA) testing, auto refraction, intraocular pressure (IOP) measurement and fundus examination. RESULTS: In the present study 166 cases (23...
January 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28352076/interaction-of-cochlin-and-mechanosensitive-channel-trek-1-in-trabecular-meshwork-cells-influences-the-regulation-of-intraocular-pressure
#17
Teresia A Carreon, Aida Castellanos, Xavier Gasull, Sanjoy K Bhattacharya
This work was funded by National Institute of Health Grants R01 EY016112, EY015266, and EY014801 and an unrestricted grant to the University of Miami's Bascom Palmer Eye Institute from Research to Prevent Blindness. Financial support from Fight for Sight is gratefully acknowledged. Funding to XG was provided by Instituto de Salud Carlos III, Spain (FIS PI14/00141 and RETIC RD12/0034/0003) and Generalitat de Catalunya (2014SGR1165). In the eye, intraocular pressure (IOP) is tightly regulated and its persistent increase leads to ocular hypertension and glaucoma...
March 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28342558/high-intensity-focused-ultrasound-as-first-line-treatment-in-patients-with-chronic-angle-closure-glaucoma-at-risk-for-malignant-glaucoma
#18
M Graber, Z Khoueir, A Beauchet, N Benhatchi, S Hammoud, Y Lachkar
PURPOSE: Evaluation of high intensity focused ultrasound (HIFU) transscleral cyclocoagulation as an alternative to trabeculectomy in the treatment of refractory chronic angle closure glaucoma (CACG). METHODS: This prospective one armed single center pilot study was conducted on patients with medically uncontrolled CACG who underwent high intensity focused ultrasound (HIFU) cyclocoagulation as first line surgical treatment, using the Eye-OP1 HIFU device (Eyetechcare-Rillieux-la-Pape, France) driven by ultrasound biomicroscopic (UBM) ciliary body localization...
April 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28333895/visual-field-defects-in-young-patients-with-open-angle-glaucoma-comparison-between-high-tension-and-normal-tension-glaucoma
#19
Ji-Hye Park, Chungkwon Yoo, Jinhwan Park, Yong Yeon Kim
PURPOSE: To investigate the clinical features of young Korean patients with open-angle glaucoma (OAG), and to compare visual field (VF) defects between patients with normal-tension glaucoma (NTG) and those with high-tension glaucoma (HTG). MATERIALS AND METHODS: Patients with OAG younger than 40 years of age were divided into NTG and HTG groups based on untreated intraocular pressure (IOP) level. The patients were matched according to the mean deviation of standard automated perimetry...
March 22, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28304388/pirfenidone-inhibits-post-traumatic-proliferative-vitreoretinopathy
#20
B N M K Khanum, R Guha, V P Sur, S Nandi, S K Basak, A Konar, S Hazra
PurposeThe purpose of the study was to evaluate the efficacy and safety of intravitreal pirfenidone for inhibition of proliferative vitreoretinopathy (PVR) in a model of penetrating ocular injury.Patients and methodsPenetrating trauma was induced on the retina of rabbit and treated either with 0.1 ml of phosphate-buffered saline (PBS) or 0.1 ml of 0.5% pirfenidone, and development of PVR was evaluated clinically and graded after 1 month. Histopathology and immunohistochemistry with transforming growth factor beta (TGFβ), alpha smooth muscle actin (αSMA), and collagen-1 were performed to assess the fibrotic changes...
March 17, 2017: Eye
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