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High eye pressure

David F Woodward, Stacey L Wenthur, Tara L Rudebush, Shan Fan, Carol B Toris
PURPOSE: Since all prostanoid receptors affect intraocular pressure (IOP) and endogenous prostanoids are found in ocular tissues, the pressor effects of prostanoid antagonists were comprehensively evaluated. The absence of effects of most of these antagonists was not entirely anticipated. To ensure no false-negative results, ocular biodisposition studies were conducted. METHODS: Monkeys with laser-induced ocular hypertension were used to study antagonist effects on IOP...
October 20, 2016: Journal of Ocular Pharmacology and Therapeutics
Goichi Akiyama, Celso Soiti Matsumoto, Kei Shinoda, Gaku Terauchi, Harue Matsumoto, Emiko Watanabe, Takeshi Iwata, Atsushi Mizota, Yozo Miyake
Scleral indentation is widely used to examine the peripheral fundus, however it can increase the intraocular pressure (IOP) to high levels which can then affect retinal function. We evaluated the effects of scleral indentation on the macular function electrophysiologically. Intraoperative focal macular electroretinograms (iFMERGs) were recorded with and without controlling the IOP in 7 eyes. Without IOP control, the IOP increased from 21.7 ± 4.9 to 92.7 ± 20.2 mmHg significantly (P = 0.020) and the amplitudes of the b-wave (from 6...
October 20, 2016: Scientific Reports
Qing Wang, Wenwen Liu, Yili Wu, Yan Ma, Guiqiu Zhao
BACKGROUND: An investigation was carried out to find the distribution of central corneal thickness (CCT) and the association between CCT and ocular factors in a cohort of myopic Chinese adults who underwent laser refractive surgery. METHODS: Medical records of 1,190 subjects (754 males) aged from 18 to 44 years (21.5 ± 3.5 years for males and 24.9 ± 5.5 years for females) undergoing myopic refractive surgery were filtered and analysed. Each parameter was stratified by gender and eye, respectively...
October 18, 2016: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
Mao Takahashi, Tomoaki Shiba, Yuuiti Hori, Kenji Suzuki, Kohji Shirai
OBJECTIVE: Cardio ankle vascular index (CAVI) represents arterial stiffness of the aorta, femoral artery and tibial artery. We investigated whether annual change of CAVI is related to the onset of retinal abnormality on optic fundus. DESIGN AND METHOD: Subjects were 1,148 (male 47.4%) urban residents who participated in cardiovascular disease (CVD) screening in Japan during 2005- 2011. All subjects had normal finding of optic fundus at first health check and had not received medical treatment for CVD risk factor during this study...
September 2016: Journal of Hypertension
Soo Won Ko, Jong Seok Lee, Han Sung Choi, Young Gwan Ko, Hoon Pyo Hong
The use of high-pressure air instruments has become more common. Consequently, there have been a number of cases of orbital emphysema caused by contact with high-pressure air. In this case, a 62-year-old male patient visited an emergency medical center after his left eye was shot by an air compressor gun that was used to wash cars. Lacerations were observed in the upper and lower eyelids of his left eye. Radiological examinations revealed orbital emphysema, optic nerve transection, pneumocephalus, and subcutaneous emphysema in the face, neck, shoulder, and mediastinum...
September 2016: Clin Exp Emerg Med
Eduard Poltavskiy, J David Spence, Jeehyoung Kim, Heejung Bang
In the modern era, with high-throughput technology and large data size, associational studies are actively being generated. Some have statistical and clinical validity and utility, or at least have biologically plausible relationships, while others may not. Recently, the potential effect of birth month on lifetime disease risks has been studied in a phenome-wide model. We evaluated the associations between birth month and 5 cardiovascular disease-related outcomes in an independent registry of 8,346 patients from Ontario, Canada in 1977-2014...
2016: Online Journal of Public Health Informatics
Petra Füredi, Zsófia Edit Pápay, Kristóf Kovács, Borbála Dalmadi Kiss, Krisztina Ludányi, István Antal, Imre Klebovich
The number of topical fungal infections is growing, mostly owing to immunosuppressive therapy. Several topical fungal infections, such as eye mycoses, can be treated by local administration of antimycotic drugs. One major group of the antifungal agents is triazole, such as voriconazole (VCZ), which is used as the first line treatment of aspergillosis. A disadvantage of VCZ is its low water solubility making the drug difficult to administer in a liquid preparation. The lipid-based nanoparticles (LNP) have attracted increasing attention due to their advantageous properties...
October 1, 2016: Journal of Pharmaceutical and Biomedical Analysis
Lynn A Schroeder, Olivier Rufra, Nicolas Sauvageot, François Fays, Vannina Pieri, Nico J Diederich
STUDY OBJECTIVES: To explore rapid eye movement density (RD) in patients with idiopathic Parkinson disease (IPD) and to investigate its usefulness as surrogate marker of excessive daytime sleepiness, a frequent complaint in IPD patients. METHODS: Retrospective polysomnography study on 81 subjects without dementia: 29 patients with early-stage IPD (disease duration >3 y), 21 patients with middle- stage IPD (disease duration >3 and <8 y) and 31 healthy controls (HC)...
October 10, 2016: Sleep
Mohammad Waheed El-Anwar, Mohammad Abdelhady, Hazem Saeed Amer, Manar A Ghali
Introduction Due to the close anatomical relationship between the paranasal sinuses and the orbit, involvement or injury of the orbit from paranasal sinuses procedures may occur. Objectives We aimed to study the early and delayed effect of endoscopic sinus surgery on intraocular pressure (IOP). Methods We included in the study 38 patients with chronic rhinosinusitis (CRS), undergoing FESS. We performed FESS with the standard anterior to posterior approach. We measured IOP at the same time one day before surgery as well as day 1 and 6 weeks after surgery...
October 2016: International Archives of Otorhinolaryngology
Richard Lindstrom, Richard Lewis, Dana M Hornbeak, Lilit Voskanyan, Jane Ellen Giamporcaro, John Hovanesian, Steven Sarkisian
INTRODUCTION: The study objective was to evaluate the intraocular pressure (IOP) and medication-lowering effect of 2 second-generation trabecular micro-bypass stents in eyes with open-angle glaucoma (OAG) on one preoperative medication. METHODS: Fifty-seven qualified phakic eyes with OAG on 1 medication, preoperative medicated IOP of 18-30 mmHg, and preoperative unmedicated (post-washout) IOP of 22-38 mmHg underwent implantation of 2 second-generation trabecular micro-bypass stents in a standalone procedure...
October 13, 2016: Advances in Therapy
Juntao Yin, Cuiyu Xiang, Guangxiu Lu
Palmatine (PM) is a potent anti-infective agent used to treat eye diseases. However, PM is less effective for ocular application due to short residence time within the eyes. This study aimed to develop a cationic lipid emulsions (CLEs) for ophthalmic delivery of PM and evaluate its suitability in infection treatment. PM-loaded CLEs (PM-CLEs) were prepared through emulsifying/high pressure homogenization and characterized by particle size, ζ potential and morphology. The resulting PM-CLEs possessed a particle size of 192 nm and ζ potential of 45 mV around...
October 13, 2016: Journal of Microencapsulation
Grzegorz Doruchowski, Waldemar Świechowski, Sylwester Masny, Alicja Maciesiak, Małgorzata Tartanus, Hanna Bryk, Ryszard Hołownicki
The coarse spray air-induction nozzles have documented pesticide drift reducing potential and hence pose lower risk of environmental pollution than the standard fine spray hollow cone nozzles. However, it is questioned that use of the low-drift nozzles might not provide as effective crop protection as the standard nozzles. The objective of work was to assess the pest and disease control efficacy as affected by spray volume rate and nozzle type. The experiment was carried out in apple orchard, cv Jonagold/M26...
October 6, 2016: Science of the Total Environment
L Ludwig, L McWhirter, S Williams, C Derry, J Stone
Functional coma - here defined as a prolonged motionless dissociative attack with absent or reduced response to external stimuli - is a relatively rare presentation. In this chapter we examine a wide range of terms used to describe states of unresponsiveness in which psychologic factors are relevant to etiology, such as depressive stupor, catatonia, nonepileptic "pseudostatus," and factitious disorders, and discuss the place of functional or psychogenic coma among these. Historically, diagnosis of functional coma has sometimes been reached after prolonged investigation and exclusion of other diagnoses...
2017: Handbook of Clinical Neurology
Brian Jarrett, Michael Secko
BACKGROUND: Choroid detachment is a rare disease process that has a multitude of etiologies; usually related to recent ophthalmological surgery, eye trauma, corneal ulcers, or intraocular pressure-lowering agents. Point-of-care ocular ultrasound has high utility and accuracy in diagnosing pathology of the eye. CASE REPORT: We present a case of a patient who presented with vision loss caused by a choroid detachment diagnosed on point-of-care ultrasound because fundoscopic examination was limited due to cataracts...
October 3, 2016: Journal of Emergency Medicine
M Pattmöller, N Szentmáry, T Eppig, D Groß, B Seitz
Background: The objective of this clinical trial was to confirm the safety of phosphate-free high molecular weight hyaluronate (HYLO®-GEL) as lubricant for postoperative care after penetrating keratoplasty. Patients and Methods: 51 eyes were followed up 6 weeks after penetrating keratoplasty under therapy with phosphate-free high molecular weight hyaluronate. Visual acuity, intraocular pressure, conjunctival hyperaemia, conjunctival chemosis, corneal fluorescein staining, corneal infiltrates, corneal endothelial-epithelial decompensation, Descemet's folds, Tyndall effect, cells in the anterior chamber and subjective assessment of lacrimation, foreign body sensation, pressure sensation, burning, mucus and itching were recorded on the first, third and fifth postoperative days and six weeks postoperatively...
October 6, 2016: Klinische Monatsblätter Für Augenheilkunde
Stefan Pfennigsdorf, Peter Eschstruth, Stefan Häsemeyer, Cord Feuerhake, Gerrett Brief, Ioana Grobeiu, Andrew Shirlaw
PURPOSE: The aim of this study was to evaluate the efficacy and tolerability of, and compliance to, preservative-free (PF), fixed-combination (FC) bimatoprost 0.03%/timolol 0.5% in patients with primary open-angle glaucoma or ocular hypertension in a clinical practice setting. PATIENTS AND METHODS: This open-label study observed patients switched to PF FC bimatoprost 0.03%/timolol 0.5% due to insufficient intraocular pressure (IOP) control on previous therapies...
2016: Clinical Ophthalmology
Hyun Tae Kim, Joon Mo Kim, Jung Hoon Kim, Jae Hyuck Lee, Mi Yeon Lee, Jae Yeun Lee, Yu Sam Won, Ki Ho Park, Hyun Seok Kwon
PURPOSE: To evaluate the relationship between intraocular pressure (IOP) and various anthropometric measures. DESIGN: A population-based cross-sectional study. METHODS: Patients: A total of 5,008 participants, 2,080 men and 2,928 women, aged ≥19 years were included from the Korea National Health and Nutrition Examination Survey V database, focusing on the years 2010 and 2011. We selected IOP in the right eye of a normal healthy population as the outcome variable of our study...
October 1, 2016: American Journal of Ophthalmology
Hala El Rami, Rasha Barham, Jennifer K Sun, Paolo S Silva
Diabetic retinopathy (DR) is the most frequent microvascular complication from diabetes and requires annual screening and at least annual follow-up. A systemic approach to optimize blood glucose and blood pressure may halt progression to severe stages of DR and obviate the need for ocular treatment. Although there is evidence of benefit from fenofibrate or intravitreous antiVEGF treatment for eyes with nonproliferative DR (NPDR), these therapies are not standard care for NPDR at this time. Some patients with severe NPDR, especially those with type 2 diabetes, benefit from early panretinal photocoagulation (PRP)...
October 4, 2016: Seminars in Ophthalmology
Jeanne Montastruc, David Amarantini, Valérie Lambert, Evelyne Castel-Lacanal, Philippe Marque, David Gasq
OBJECTIVE: Weight-bearing asymmetry (WBA) at the expense of the paretic side concerns 60% of stroke patients. WBA is associated with poor functional prognosis especially in terms of gait performance [1,2]. The primary objective was to assess the determinants of WBA in stroke patients from clinical and instrumental data. MATERIAL/PATIENTS AND METHODS: The sensitivity (EmNSA), motricity (Fugl-Meyer motor), spatial neglect and visual perception of verticality (VPV) were evaluated in 20 stroke patients (age: 53...
September 2016: Annals of Physical and Rehabilitation Medicine
David Gasq, Morgane Lainard, Laure Kaluza, Philippe Dupui, David Amarantini
OBJECTIVE: When subjects present medically unexplained postural instability, a voluntary overcontrol of postural sway is often suspected. Aphysiologic postural imbalance may be detected in dynamic conditions on a servo-controlled platform (Equitest), but it remains difficult to objectify from static stabilometric evaluation. Our objective was to identify the key stabilometric parameters that allow to discriminate subjects with voluntary postural instability, control subjects and neurological patients with organic postural instability...
September 2016: Annals of Physical and Rehabilitation Medicine
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