Cristian Loretelli, Ida Pastore, Maria Elena Lunati, Ahmed Abdelsalam, Vera Usuelli, Emma Assi, Emma Fiorina, Lara Loreggian, Hari Baskar Balasubramanian, Yanan Xie, Jun Yang, Basset El Essawy, Laura Montefusco, Francesca D'Addio, Moufida Ben Nasr, Paolo Fiorina
PURPOSE OF REVIEW: The purine nucleotide adenosine triphosphate (ATP) is released into extracellular spaces as extracellular ATP (eATP) as a consequence of cell injury or death and activates the purinergic receptors. Once released, eATP may facilitate T-lymphocyte activation and differentiation. The purpose of this review is to elucidate the role of ATP-mediated signaling in the immunological events related to type 1 diabetes (T1D). RECENT FINDINGS: T lymphocytes mediate immune response during the onset of T1D and promote pancreatic islet or whole pancreas rejection in transplantation...
February 24, 2023: Pharmacological Research: the Official Journal of the Italian Pharmacological Society