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https://www.readbyqxmd.com/read/29142617/acute-strenuous-exercise-induces-an-imbalance-on-histone-h4-acetylation-histone-deacetylase-2-and-increases-the-proinflammatory-profile-of-pbmc-of-obese-individuals
#1
Gilson P Dorneles, Maria Carolina R Boeira, Lucas L Schipper, Ivy R V Silva, Viviane R Elsner, Pedro Dal Lago, Alessandra Peres, Pedro R T Romão
This study evaluated the response of global histone H4 acetylation (H4ac), histone deacetylase 2 (HDAC2) activity, as well as the production of proinflammatory cytokines and monocyte phenotypes of lean and obese males after exercise. Ten lean and ten obese sedentary men were submitted to one session of strenuous exercise, and peripheral blood mononuclear cells (PBMC) were stimulated in vitro with lipopolysaccharide (LPS). Global H4ac levels, HDAC2 activity in PBMC, and IL-6, IL-8, and TNF-α production were analyzed...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29141570/effect-of-extra-virgin-olive-oil-and-table-olives-on-the-immune-inflammatory-responses-potential-clinical-applications
#2
Caterina Maria Gambino, Giulia Accardi, Anna Aiello, Giuseppina Candore, Giovanni Dara-Guccione, Mario Mirisola, Antonio Procopio, Giusi Taormina, Calogero Caruso
Extra virgin olive oil (EVOO) is the common element between the Mediterranean countries. It can be considered a nutraceutical and functional food, thanks to its bioactive compounds. It can act and modulate different processes linked to ageing and age-related diseases related to a common chronic low grade inflammation. Depending on the cultivar, the growth conditions, the period of harvesting, the productive process and time of product storage, EVOO could contain different amount of vegetal components. Of course, the same is for table olives...
November 13, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29138673/the-beneficial-effects-of-quercetin-curcumin-and-resveratrol-in-obesity
#3
REVIEW
Yueshui Zhao, Bo Chen, Jing Shen, Lin Wan, Yinxin Zhu, Tao Yi, Zhangang Xiao
Over the past two decades, obesity has been one of the major public health concerns in most countries. In the search for new molecules that could be used for the treatment of obesity, good perspectives have been opened up for polyphenols, a class of natural bioactive phytochemicals. Experimental and limited clinical trial evidence supports that some polyphenols such as quercetin, curcumin, and resveratrol have potential benefit functions on obesity treatment. This brief review focuses on the main functions of the above-named polyphenols on adipose tissue...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29137891/human-leukocyte-antigen-hla-and-gulf-war-illness-gwi-hla-drb1-13-02-spares-subcortical-atrophy-in-gulf-war-veterans
#4
Lisa M James, Peka Christova, Brian E Engdahl, Scott M Lewis, Adam F Carpenter, Apostolos P Georgopoulos
BACKGROUND: Gulf War Illness (GWI) is a multisystem disorder that has affected a substantial number of veterans who served in the 1990-91 Gulf War. The brain is prominently affected, as manifested by the presence of neurological, cognitive and mood symptoms. We reported previously on the protective role of six Human Leukocyte Antigen (HLA) alleles in GWI (Georgopoulos et al., 2016) and their association with regional brain function (James et al., 2016). More recently, we reported on the presence of subcortical brain atrophy in GWI (Christova et al...
November 9, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29135935/tucum-do-cerrado-bactris-setosa-mart-may-promote-anti-aging-effect-by-upregulating-sirt1-nrf2-pathway-and-attenuating-oxidative-stress-and-inflammation
#5
Marcela de Sá Barreto da Cunha, Sandra Fernandes Arruda
Aging may be related to oxidative damage accumulation and a low-grade inflammation, both responses are modulated by iron and phytochemicals. This study investigated the effect of tucum-do-cerrado (Bactris setosa Mart.) consumption on the expression of sirtuins (SIRT 1 and 3) and senescence marker protein-30 (SMP30), and on the redox and inflammatory responses, in adult rats supplemented or not with dietary iron. Male Wistar rats were treated for 12 weeks with: control diet (CT); iron enriched-diet (+Fe); control diet + 15% tucum-do-cerrado (Tuc); or iron enriched-diet + 15% tucum-do-cerrado (Tuc + Fe)...
November 14, 2017: Nutrients
https://www.readbyqxmd.com/read/29135455/transcriptome-wide-association-study-of-inflammatory-biologic-age
#6
Honghuang Lin, Kathryn L Lunetta, Qiang Zhao, Jian Rong, Emelia J Benjamin, Michael M Mendelson, Roby Joehanes, Daniel Levy, Martin G Larson, Joanne M Murabito
Chronic low grade inflammation is a fundamental mechanism of aging. We estimated biologic age using nine biomarkers from diverse inflammatory pathways and we hypothesized that genes associated with inflammatory biological age would provide insights into human aging. In Framingham Offspring Study participants at examination 8 (2005 to 2008), we used the Klemera-Doubal method to estimate inflammatory biologic age and we computed the difference (∆Age) between biologic age and chronologic age. Gene expression in whole blood was measured using the Affymetrix Human Exon 1...
November 11, 2017: Aging
https://www.readbyqxmd.com/read/29132135/increased-th1-th17-responses-contribute-to-low-grade-inflammation-in-age-related-macular-degeneration
#7
Jiajia Chen, Wenzhan Wang, Qiuming Li
BACKGROUND/AIMS: Age-related macular degeneration (AMD) is the primary cause of senior blindness in developed countries. Mechanisms underlying initiation and development of AMD remained known. METHODS: We examined the CD4+ T cell compartments and their functions in AMD patients. RESULTS: AMD patients presented significantly higher frequencies of interferon (IFN)-γ-expressing and interleukin (IL)-17-expressing CD4+ T cells than healthy controls...
November 13, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29131526/amniotic-mesenchymal-stem-cells-mitigate-osteoarthritis-progression-in-a-synovial-macrophage-mediated-in-vitro-explant-co-culture-model
#8
Natasha Topoluk, Kathleen Steckbeck, Sandra Siatkowski, Brian Burnikel, John Tokish, Jeremy Mercuri
Osteoarthritis (OA) is a disease of the synovial joint marked by chronic, low-grade inflammation leading to cartilage destruction. Regenerative medicine strategies for mitigating OA progression and/or promoting cartilage regeneration must be assessed using models that mimic the hallmarks of OA. More specifically, these models should maintain synovial macrophage phenotype in their native micro-environment. Herein, an in vitro co-culture model of patient-matched human OA cartilage and synovium was assessed for viability, macrophage phenotype, and progressive cartilage destruction in the presence of an inflammatory milieu...
November 13, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29131494/antimicrobial-emulsifier-glycerol-monolaurate-induces-metabolic-syndrome-gut-microbiota-dysbiosis-and-systemic-low-grade-inflammation-in-low-fat-diet-fed-mice
#9
Zengliang Jiang, Minjie Zhao, Hui Zhang, Yang Li, Mengyun Liu, Fengqin Feng
SCOPE: Glycerol monolaurate (GML) was widely consumed worldwide in food industry, and considered as safe, yet for chronic diseases, supporting scientific data remain sparse. This study was to investigate whether dietary GML induces metabolic syndrome, gut microbiota dysbiosis and systemic low-grade inflammation. METHODS AND RESULTS: GML-induced occurrence of metabolic syndrome, gut microbiota alterations and systemic low-grade inflammation were investigated. Our results demonstrated that GML induced metabolic syndrome by significantly increasing the body weight, weight gain, food intake, body fat, fat droplet size and percentage of epididymal fat, serum triglycerides (TG), LDL and atherogenic index, and decreasing the body muscle ratio, liver weight and HDL, compared to the CON group...
November 13, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29129737/endotoxemia-is-modulated-by-quantity-and-quality-of-dietary-fat-in-older-adults
#10
Javier Lopez-Moreno, Sonia Garcia-Carpintero, Francisco Gomez-Delgado, Rosa Jimenez-Lucena, Cristina Vals-Delgado, Juan F Alcala-Diaz, Irene Roncero-Ramos, Oriol A Rangel-Zuñiga, Elena M Yubero-Serrano, Maria M Malagon, Jose M Ordovas, Pablo Perez-Martinez, Jose Lopez-Miranda, Antonio Camargo
BACKGROUND: Aging is an important determinant of the rate of atherosclerosis development, mainly through low-grade inflammation. Diet, and particularly its fat content, modulates the inflammatory response in fasting and postprandial states. OBJECTIVE: We aimed to study the effects of dietary fat on endotoxemia in healthy older adults. MATERIALS AND METHODS: Twenty healthy older adults were randomized to three diets, lasting three-weeks each, using a crossover design: 1...
November 9, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29128509/monocyte-activation-is-elevated-in-women-with-knee-osteoarthritis-and-associated-with-inflammation-bmi-and-pain
#11
Dessi Loukov, Sarah Karampatos, Monica R Maly, Dawn M E Bowdish
OBJECTIVE: Monocytes contribute to synovitis and disease pathogenesis in OA. Low-grade inflammation occurs in OA and correlates with disease severity and progression. Since monocyte development and function is altered by systemic inflammation, we analyzed monocyte numbers and function between individuals with knee OA and healthy age- and sex-matched controls. DESIGN: We analyzed markers of soluble and cellular inflammation in peripheral blood of women with knee OA and compared them to healthy age- and sex-matched controls...
November 8, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29128402/an-anti-inflammatory-chalcone-derivative-prevents-heart-and-kidney-from-hyperlipidemia-induced-injuries-by-attenuating-inflammation
#12
Xiong Chen, Weihui Yu, Weixin Li, Hailing Zhang, Weijian Huang, Jingying Wang, Weiwei Zhu, Qilu Fang, Chao Chen, Xiaokun Li, Guang Liang
Obesity is a growing pandemic in both developed and developing countries. Lipid overload in obesity generates a chronic, low-grade inflammation state. Increased inflammation in heart and renal tissues has been shown to promote the progression of heart and renal damage in obesity. Previously, we found that a novel chalcone derivative, L6H21, inhibited lipopolysaccharide-induced inflammatory response. In the present study, we investigated the effects of L6H21 on inflammatory responses in culture and in animal models of lipid overload...
November 8, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29127503/relationships-between-low-grade-peripheral-inflammation-and-psychotropic-drugs-in-schizophrenia-results-from-the-national-face-sz-cohort
#13
G Fond, N Resseguier, F Schürhoff, O Godin, M Andrianarisoa, L Brunel, E Bulzacka, B Aouizerate, F Berna, D Capdevielle, I Chereau, T D'Amato, C Dubertret, J Dubreucq, C Faget, F Gabayet, C Lançon, P M Llorca, J Mallet, D Misdrahi, C Passerieux, R Rey, A Schandrin, M Urbach, P Vidailhet, L Boyer, M Leboyer
Low-grade inflammation has repeatedly been associated with schizophrenia (SZ) and in particular with cognitive impairment. Female gender, overweight and tobacco smoking have been suggested as risk factors to increase inflammation while preclinical inconsistent findings have been found regarding the association with psychotropic drugs. The aim of this study was to explore if psychotropic drugs were associated with inflammation in SZ and to determine which psychotropic drug was associated with inflammation in stable SZ subjects while considering clinical confounding factors...
November 10, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/29121681/concurrent-training-with-blood-flow-restriction-does-not-decrease-inflammatory-markers
#14
Thiago Mattos Frota de Souza, Cleiton Augusto Libardi, Cláudia Regina Cavaglieri, Arthur Fernandes Gáspari, Diego Trevisan Brunelli, Giovana Vergínia de Souza, Carlos Ugrinowitsch, Li Min Li, Mara Patricia Traina Chacon-Mikahil
The aging process is associated with several changes in the elderly such as the decrease in cardiorespiratory fitness, strength and muscle mass, in addition to chronic low-grade inflammation. Concurrent training with blood flow restriction can be an interesting alternative to improve functional capacity with low mechanical stress in the elderly. The purpose of this study was to compare the inflammatory effects in older individuals submitted to two different protocols of concurrent training. Twenty-two healthy older adults (63...
November 9, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29121255/adipocyte-expression-of-slc19a1-links-dna-hypermethylation-to-adipose-tissue-inflammation-and-insulin-resistance
#15
Paul Petrus, Lucia Bialesova, Antonio Checa, Alastair Kerr, Shama Naz, Jesper Bäckdahl, Ana Gracia, Sofia Toft, Karin Dahlman-Wright, Per Hedén, Ingrid Dahlman, Craig E Wheelock, Peter Arner, Niklas Mejhert, Hui Gao, Mikael Rydén
Context: Insulin resistance (IR) is promoted by a chronic low-grade inflammation in white adipose tissue (WAT). The latter may be regulated through epigenetic mechanisms such as DNA-methylation. The one carbon cycle (1CC) is a central metabolic process governing DNA-methylation. Objective: To identify adipocyte-expressed 1CC genes linked to WAT inflammation, IR and their causal role. Design: Cohort study. Setting: Outpatient academic clinic...
November 7, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29119922/polyphenols-anti-platelet-nutraceutical
#16
Valeria Ludovici, Jens Barthelmes, Matthias P Nägele, Andreas J Flammer, Isabella Sudano
BACKGROUND: Coronary artery disease (CAD) is a disease progressing over many years. Genetic factors, as well as the exposure to risk factors, are continuously leading to endothelial dysfunction, vascular alterations and, eventually, organ damage, major cardiovascular events and deaths. Oxidative stress, platelet hyperactivity and low-grade inflammation are important modulators in this context, contributing to plaque formation. Since platelet activation plays a critical role in the development and progression of atherothrombotic events, the inhibition of platelet hyperactivity may contribute to decreased atherothrombotic risk...
November 8, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29113510/interrelationship-of-canonical-and-non-canonical-wnt-signalling-pathways-in-chronic-metabolic-diseases
#17
Ian Ackers, Ramiro Malgor
Chronic diseases account for approximately 45% of all deaths in developed countries and are particularly prevalent in countries with the most sophisticated and robust public health systems. Chronic metabolic diseases, specifically lifestyle-related diseases pertaining to diet and exercise, continue to be difficult to treat clinically. The most prevalent of these chronic metabolic diseases include obesity, diabetes, non-alcoholic fatty liver disease, chronic kidney disease and cardiovascular disease and will be the focus of this review...
November 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29113318/follicular-metabolic-changes-and-effects-on-oocyte-quality-in-polycystic-ovary-syndrome-patients
#18
Yan Zhang, Lingyan Liu, Tai-Lang Yin, Jing Yang, Cheng-Liang Xiong
Polycystic ovary syndrome (PCOS) is a common complex and heterogeneous disorder, affecting up to 10% women at reproductive age. It causes three fourth of the ovulatory infertility and PCOS patients often give poor IVF quality. Although some metabolic profiles have been investigated in PCOS patient sera and urine, the follicular fluid, providing fruitful biochemical information about oocyte environment during development has been ignored. In this work, based on NMR metabolomics approach, metabolic profile of follicular fluid of PCOS patients has been explored and compared with healthy controls...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29113045/pilot-study-comparison-of-sourdough-wheat-bread-and-yeast-fermented-wheat-bread-in-individuals-with-wheat-sensitivity-and-irritable-bowel-syndrome
#19
Reijo Laatikainen, Jari Koskenpato, Sanna-Maria Hongisto, Jussi Loponen, Tuija Poussa, Xin Huang, Tuula Sontag-Strohm, Hanne Salmenkari, Riitta Korpela
Many patients suspect wheat as being a major trigger of their irritable bowel syndrome (IBS) symptoms. Our aim was to evaluate whether sourdough wheat bread baked without baking improvers and using a long dough fermentation time (>12 h), would result in lower quantities of alpha-amylase/trypsin inhibitors (ATIs) and Fermentable, Oligo-, Di-, Mono-saccharides and Polyols (FODMAPs), and would be better tolerated than yeast-fermented wheat bread for subjects with IBS who have a poor subjective tolerance to wheat...
November 4, 2017: Nutrients
https://www.readbyqxmd.com/read/29107169/the-complement-system-is-dysfunctional-in-metabolic-disease-evidences-in-plasma-and-adipose-tissue-from-obese-and-insulin-resistant-subjects
#20
REVIEW
José María Moreno-Navarrete, José Manuel Fernández-Real
The relationship between chronic low-grade inflammation, insulin resistance and other obesity-associated metabolic disturbances is increasingly recognized. The possible mechanisms that trigger these immunologic alterations remain to be fully understood. The complement system is a crucial element of immune defense system, being important in the activation of innate and adaptative immune response, promoting the clearance of apoptotic and damaged endogenous cells and participating in processes of tissue development, degeneration, and regeneration...
October 26, 2017: Seminars in Cell & Developmental Biology
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