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https://www.readbyqxmd.com/read/28110395/relative-contribution-of-health-related-behaviours-and-chronic-diseases-to-the-socioeconomic-patterning-of-low-grade-inflammation
#1
Marialaura Bonaccio, Augusto Di Castelnuovo, George Pounis, Amalia De Curtis, Simona Costanzo, Mariarosaria Persichillo, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano, Licia Iacoviello
OBJECTIVES: To test the association of low-grade inflammation with socioeconomic status (SES) and determine the relative contribution of prevalent chronic diseases and health-related behaviours in explaining such association. METHODS: Cross-sectional analysis on 19,867 subjects (age ≥35, 48.1% men) recruited within the Moli-sani study from 2005 to 2010 (Italy). A score of low-grade inflammation, including platelet and leukocyte counts, the granulocyte-to-lymphocyte ratio, and C-reactive protein was applied...
January 21, 2017: International Journal of Public Health
https://www.readbyqxmd.com/read/28108279/redox-regulation-of-cardiovascular-inflammation-immunomodulatory-function-of-mitochondrial-and-nox-derived-reactive-oxygen-and-nitrogen-species
#2
REVIEW
Philip Wenzel, Sabine Kossmann, Thomas Münzel, Andreas Daiber
Oxidative stress is a major hallmark of cardiovascular diseases although a causal link was so far not proven by large clinical trials. However, there is a close association between oxidative stress and inflammation and increasing evidence for a causal role of (low-grade) inflammation for the onset and progression of cardiovascular diseases, which may serve as the missing link between oxidative stress and cardiovascular morbidity and mortality. With the present review we would like to highlight the multiple redox regulated pathways in inflammation, discuss the sources of reactive oxygen and nitrogen species that are of interest for these processes and finally discuss the importance of angiotensin II (AT-II) as a trigger of cardiovascular inflammation and the initiation and progression of cardiovascular diseases...
January 17, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28107669/medical-comorbidity-in-bipolar-disorder-the-link-with-metabolic-inflammatory-systems
#3
REVIEW
Ana SayuriYamagata, Elisa Brietzke, Joshua D Rosenblat, Ron Kakar, Roger S McIntyre
BACKGROUND: Bipolar disorder (BD) is associated with chronic low-grade inflammation, several medical comorbidities and a decreased life expectancy. Metabolic-inflammatory changes have been postulated as one of the main links between BD and medical comorbidity, although there are few studies exploring possible mechanisms underlying this relationship. Therefore, the aims of the current narrative review were 1) synthesize the evidence for metabolic-inflammatory changes that may facilitate the link between medical comorbidity and BD and 2) discuss therapeutic and preventive implications of these pathways...
January 4, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28105870/association-of-serum-uric-acid-with-high-sensitivity-c-reactive-protein-in-postmenopausal-women
#4
A Raeisi, A Ostovar, K Vahdat, P Rezaei, H Darabi, D Moshtaghi, I Nabipour
OBJECTIVES: To explore the independent correlation between serum uric acid and low-grade inflammation (measured by high-sensitivity C-reactive protein, hs-CRP) in postmenopausal women. METHODS: A total of 378 healthy Iranian postmenopausal women were randomly selected in a population-based study. Circulating hs-CRP levels were measured by highly specific enzyme-linked immunosorbent assay method and an enzymatic calorimetric method was used to measure serum levels of uric acid...
February 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28103784/the-multi-faceted-profile-of-corticotropin-releasing-factor-crf-family-of-neuropeptides-and-of-their-receptors-on-the-paracrine-local-regulation-of-the-inflammatory-response
#5
Andrew N Margioris, Eirini Dermitzaki, Maria Venihaki, Christos Tsatsani, Achille Gravanis, Pavlina Avgoustinaki, George Liapakis
The corticotropin releasing factor (CRF) family of neuropeptides, CRF and the Urocortins, and their receptors are present not only within the central nervous system but also in the periphery at various locations and at the sites of inflammation where they influence its progress in a complex local / paracrine manner. These neuropeptides are either produced locally, by components of the inflammatory response or they may reach the inflammation sites via postganglionic sympathetic and sensory afferent nerve transport...
January 9, 2017: Current Molecular Pharmacology
https://www.readbyqxmd.com/read/28093569/translational-evaluation-of-translocator-protein-as-a-marker-of-neuroinflammation-in-schizophrenia
#6
T Notter, J M Coughlin, T Gschwind, U Weber-Stadlbauer, Y Wang, M Kassiou, A C Vernon, D Benke, M G Pomper, A Sawa, U Meyer
Positron emission tomography (PET) imaging with radiotracers that target translocator protein 18 kDa (TSPO) has become a popular approach to assess putative neuroinflammatory processes and associated microglia activation in psychotic illnesses. It remains unclear, however, whether TSPO imaging can accurately capture low-grade inflammatory processes such as those present in schizophrenia and related disorders. Therefore, we evaluated the validity of TSPO as a disease-relevant marker of inflammation using a translational approach, which combined neurodevelopmental and neurodegenerative mouse models with PET imaging in patients with recent-onset schizophrenia and matched controls...
January 17, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28093357/are-the-innate-and-adaptive-immune-systems-setting-hypertension-on-fire
#7
REVIEW
Gisele F Bomfim, Fernanda Luciano Rodrigues, Fernando S Carneiro
Hypertension is the most common chronic cardiovascular disease and is associated with several pathological states, being an important cause of morbidity and mortality around the world. Low-grade inflammation plays a key role in hypertension and the innate and adaptive immune systems seem to contribute to hypertension development and maintenance. Hypertension is associated with vascular inflammation, increased vascular cytokines levels and infiltration of immune cells in the vasculature, kidneys and heart. However, the mechanisms that trigger inflammation and immune system activation in hypertension are completely unknown...
January 13, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28088464/microparticles-inflammatory-and-haemostaticbiomarkers-in-polycystic-ovary-syndrome
#8
L M L Carvalho, C N Ferreira, M O Sóter, M F Sales, K F Rodrigues, S R Martins, A L Candido, F M Reis, I O Silva, F M F Campos, K B Gomes
Polycystic Ovary Syndrome (PCOS) is associated with a chronic low-grade inflammation and predisposition to hemostatic and atherosclerotic complications. This case-control study evaluated the microparticles (MPs) profile in patients with the PCOS and related these MPs to clinical and biochemical parameters. MPs derived from platelets (PMPs), leuckocytes (LMPs) and endothelial cells (EMPs) were evaluated, as well as MPs expressing tissue factor (TFMPs), by flow cytometry, comparing women with PCOS (n = 50) and a healthy control group (n = 50)...
January 11, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28087373/chronoinflammaging-in-alzheimer-a-systematic-review-on-the-roles-of-toll-like-receptor-2
#9
REVIEW
Ali Ravari, Tayebeh Mirzaei, Derek Kennedy, Mohammad Kazemi Arababadi
Aging is associated with a range of chronic low-grade inflammation (Chronoinflammaging) which may play a significant role in some chronic inflammatory based diseases, such as Alzheimer disease (AD). However, the events which lead to the induction of chronoinflammaging in AD are yet to be clarified. It has been proposed that the recognition of endogenous ligands by pathogen recognition receptors (PRRs) may be involved in the induction of chronoinflammaging. Toll like receptors (TLRs) are a family of PRRs which recognize endogenous damage associated molecular patterns (DAMPs) and subsequently induce inflammation...
January 10, 2017: Life Sciences
https://www.readbyqxmd.com/read/28072592/metabolic-syndrome-associated-osteoarthritis
#10
Alice Courties, Jérémie Sellam, Francis Berenbaum
PURPOSE OF REVIEW: Interest in the metabolic syndrome-associated osteoarthritis phenotype is increasing. Here, we summarize recently published significant findings. RECENT FINDINGS: Meta-analyses confirmed an association between type 2 diabetes and osteoarthritis and between cardiovascular diseases and osteoarthritis. Recent advances in the study of metabolic syndrome-associated osteoarthritis have focused on a better understanding of the role of metabolic diseases in inducing or aggravating joint damage...
January 7, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28067176/the-linkage-between-inflammation-and-immune-tolerance-interfering-with-inflammation-in-cancer
#11
Vladimir Stanislavovich Rogovskii
Inflammation is linked to immune tolerance. In pregnancy and in immune privileged organs constitutive low-grade inflammation is required for maintaining immunological tolerance. Apart from immune tolerance in normality, there is the phenomenon of immune tolerance in cancer which mediates tumor escape from the immune system. It is widely accepted that, in many situations, chronic inflammation critically contributes to cancer. Like other types of immune tolerance, tumor-induced tolerance is also mediated by inflammation...
January 9, 2017: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/28066896/parasite-excretory-secretory-products-and-their-effects-on-metabolic-syndrome
#12
Jenny Crowe, Felicity E Lumb, Margaret M Harnett, William Harnett
Obesity, one of the main causes of metabolic syndrome (MetS), is an increasingly common health and economic problem worldwide, and one of the major risk factors for developing type 2 diabetes and cardiovascular disease. Chronic, low-grade inflammation is associated with MetS and obesity. A dominant type 2/anti-inflammatory response is required for metabolic homeostasis within adipose tissue: during obesity, this response is replaced by infiltrating, inflammatory macrophages and T cells. Helminths and certain protozoan parasites are able to manipulate the host immune response towards a TH2 immune phenotype that is beneficial for their survival and there is emerging data that there is an inverse correlation between the incidence of MetS and helminth infections, suggesting that, as with autoimmune and allergic diseases, helminths may play a protective role against MetS disease...
January 9, 2017: Parasite Immunology
https://www.readbyqxmd.com/read/28056291/-the-impacts-of-testosterone-on-insulin-sensitivity-and-chronic-low-grade
#13
C L Su, M Chen, W Xu, J F Lin
Objectives: Insulin resistance (IR) is a common manifestation in patients with polycystic ovarian syndrome (PCOS). Both clinical observations and animal studies have demonstrated that IR could be induced by hyperandrogenemia, which is the charac-teristic of PCOS.Nevertheless, the mechanisms of IR in PCOS are still unclear especially at the molecular level.We conduct this study to ellucidate the effects of androgen on insulin sensitivity and chronic low-grade inflammation in adult C57BL/6 female mice. Methods: Eleven adult female C57BL/6 mice aged 8 weeks weredaily injected with testosterone (1...
January 3, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28054366/the-role-of-molecular-pain-biomarkers-in-temporomandibular-joint-internal-derangement
#14
REVIEW
Malin Ernberg
There is evidence that low-grade inflammation may be responsible for pain and development of degenerative changes in temporomandibular joint internal derangement. This article reviews the current knowledge of the molecular mechanisms behind TMJ internal derangements. A non-systematic search was carried out in PubMed, Embase, and the Cochrane library for studies regarding pathophysiological mechanisms behind internal derangements focusing on pain mediating inflammatory and cartilage degrading molecules. Recent data suggests that release of cytokines may be the key event for pain and cartilage destruction in TMJ internal derangements...
January 5, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28045919/alterations-in-gut-microbiome-composition-and-barrier-function-are-associated-with-reproductive-and-metabolic-defects-in-women-with-polycystic-ovary-syndrome-pcos-a-pilot-study
#15
Lisa Lindheim, Mina Bashir, Julia Münzker, Christian Trummer, Verena Zachhuber, Bettina Leber, Angela Horvath, Thomas R Pieber, Gregor Gorkiewicz, Vanessa Stadlbauer, Barbara Obermayer-Pietsch
BACKGROUND: Polycystic ovary syndrome (PCOS) is a common female endocrinopathy of unclear origin characterized by hyperandrogenism, oligo-/anovulation, and ovarian cysts. Women with PCOS frequently display overweight, insulin resistance, and systemic low-grade inflammation. We hypothesized that endotoxemia resulting from a leaky gut is associated with inflammation, insulin resistance, fat accumulation, and hyperandrogenemia in PCOS. In this pilot study, we compared the stool microbiome, gut permeability, and inflammatory status of women with PCOS and healthy controls...
2017: PloS One
https://www.readbyqxmd.com/read/28045403/immunologic-impact-of-the-intestine-in-metabolic-disease
#16
Daniel A Winer, Shawn Winer, Helen J Dranse, Tony K T Lam
Obesity and diabetes are associated with increased chronic low-grade inflammation and elevated plasma glucose levels. Although inflammation in the fat and liver are established features of obesity-associated insulin resistance, the intestine is emerging as a new site for immunologic changes that affect whole-body metabolism. Specifically, microbial and dietary factors incurred by diet-induced obesity influence underlying innate and adaptive responses of the intestinal immune system. These responses affect the maintenance of the intestinal barrier, systemic inflammation, and glucose metabolism...
January 3, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28045402/inflammatory-mechanisms-linking-obesity-and-metabolic-disease
#17
Alan R Saltiel, Jerrold M Olefsky
There are currently over 1.9 billion people who are obese or overweight, leading to a rise in related health complications, including insulin resistance, type 2 diabetes, cardiovascular disease, liver disease, cancer, and neurodegeneration. The finding that obesity and metabolic disorder are accompanied by chronic low-grade inflammation has fundamentally changed our view of the underlying causes and progression of obesity and metabolic syndrome. We now know that an inflammatory program is activated early in adipose expansion and during chronic obesity, permanently skewing the immune system to a proinflammatory phenotype, and we are beginning to delineate the reciprocal influence of obesity and inflammation...
January 3, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28043038/intra-individual-cortisol-variability-and-low-grade-inflammation-over-10-years-in-older-adults
#18
Heather Herriot, Carsten Wrosch, Jean-Philippe Gouin, Gregory E Miller
OBJECTIVE: This study examined the associations between intra-individual variability in, and inter-individual levels of, diurnal cortisol secretion with a marker of low-grade inflammation (i.e., C-Reactive Protein; CRP). Reasoning that greater day-to-day cortisol variability could reflect a dysregulation of the HPA axis, we hypothesized that it would predict higher levels of CRP, above and beyond inter-individual differences in cortisol levels. METHODS: A 10-year longitudinal study of 130 older adults examined diurnal cortisol secretion on three different days across each of the 6 waves of data collection and levels of CRP during the last 3 waves...
December 21, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28041986/insomnia-symptoms-with-objective-short-sleep-duration-are-associated-with-systemic-inflammation-in-adolescents
#19
Julio Fernandez-Mendoza, Joshua H Baker, Alexandros N Vgontzas, Jordan Gaines, Duanping Liao, Edward O Bixler
Inflammation has been suggested as a potential pathway by which insomnia and short sleep can affect risk of morbidity in adults. However, few studies have examined the association of insomnia with inflammation in adolescents, despite accumulating evidence that pathophysiologic changes may already occur during this critical developmental period. The present study sought to examine the association of insomnia symptoms with systemic inflammation and the role of objective sleep duration in this association. Participants were 378 adolescents (16...
December 30, 2016: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28035619/inflammation-oxidative-stress-apoptosis-and-autophagy-in-diabetes-mellitus-and-diabetic-kidney-disease-the-four-horsemen-of-the-apocalypse
#20
REVIEW
Kultigin Turkmen
Diabetic kidney disease (DKD) can occur in approximately 30-40% of both type 1 and type 2 diabetic patients. The well-established features of DKD include increased serum glucose levels along with chronic low-grade inflammation, OxS, increased advanced glycation end products, sorbitol accumulation, increased hexosamine, and protein kinase C pathway activation. On the other hand, accumulating evidence suggests that novel pathways including apoptosis and autophagy might also play important roles in the pathogenesis and progression of DKD...
December 29, 2016: International Urology and Nephrology
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