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Dopamine memantine

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https://www.readbyqxmd.com/read/27686418/treatment-with-piribedil-and-memantine-reduces-noise-induced-loss-of-inner-hair-cell-synaptic-ribbons
#1
Richard A Altschuler, Noel Wys, Diane Prieskorn, Cathy Martin, Susan DeRemer, Sanford Bledsoe, Josef M Miller
Noise overstimulation can induce loss of synaptic ribbons associated with loss of Inner Hair Cell - Auditory Nerve synaptic connections. This study examined if systemic administration of Piribedil, a dopamine agonist that reduces the sound evoked auditory nerve compound action potential and/or Memantine, an NMDA receptor open channel blocker, would reduce noise-induced loss of Inner Hair Cell ribbons. Rats received systemic Memantine and/or Piribedil for 3 days before and 3 days after a 3 hour 4 kHz octave band noise at 117 dB (SPL)...
September 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27425857/antidepressant-induced-dopamine-receptor-dysregulation-a-valid-animal-model-of-manic-depressive-illness
#2
Francesca Demontis, Francesca Serra, Gino Serra
BACKGROUND: Mania seems to be associated with an increased dopamine (DA) transmission. Antidepressant treatments can induce mania in humans and potentiated DA transmission in animals, by sensitizing DA D2 receptors in the mesolimbic system. We have suggested that the sensitization of D2 receptors may be responsible of antidepressant-induced mania. This review aims to report the experimental evidence that led to the hypothesis that antidepressant-induced DA receptors dysregulation can be considered an animal model of bipolar disorder...
July 15, 2016: Current Neuropharmacology
https://www.readbyqxmd.com/read/27354963/failure-of-memantine-to-reverse-quinpirole-induced-hypomotility
#3
Francesca Demontis, Gino Serra
AIM: To evaluate antidepressant-like effect of memantine in a rat model. METHODS: Male Wistar rats were treated intraperitoneally with either vehicle, memantine (10 mg/kg) or imipramine (20 mg/kg), for 3 wk. Twenty-four hour after the last treatment animals were challenged with quinpirole (0.3 mg/kg s.c.) and tested for motor activity. After 1 h habituation to the motility cages, the motor response was recorded for the following 45-min and the data were collected in 5-min time bins...
June 22, 2016: World Journal of Psychiatry
https://www.readbyqxmd.com/read/26997505/therapeutic-modulation-of-glutamate-receptors-in-major-depressive-disorder
#4
Brittany A Jaso, Mark J Niciu, Nicolas D Iadarola, Níall Lally, Erica M Richards, Minkyung Park, Elizabeth D Ballard, Allison C Nugent, Rodrigo Machado-Vieira, Carlos A Zarate
Current pharmacotherapies for major depressive disorder (MDD) have a distinct lag of onset that can prolong distress and impairment for patients, and real-world effectiveness trials further suggest that antidepressant efficacy is limited in many patients. All currently approved antidepressant medications for MDD act primarily through monoaminergic mechanisms, e.g., receptor/reuptake agonists or antagonists with varying affinities for serotonin, norepinephrine, or dopamine. Glutamate is the major excitatory neurotransmitter in the central nervous system, and glutamate and its cognate receptors are implicated in the pathophysiology of MDD, as well as in the development of novel therapeutics for this disorder...
March 21, 2016: Current Neuropharmacology
https://www.readbyqxmd.com/read/26609150/glutamate-receptors-within-the-mesolimbic-dopamine-system-mediate-alcohol-relapse-behavior
#5
Manuela Eisenhardt, Sarah Leixner, Rafael Luján, Rainer Spanagel, Ainhoa Bilbao
UNLABELLED: Glutamatergic input within the mesolimbic dopamine (DA) pathway plays a critical role in the development of addictive behavior. Although this is well established for some drugs of abuse, it is not known whether glutamate receptors within the mesolimbic system are involved in mediating the addictive properties of chronic alcohol use. Here we evaluated the contribution of mesolimbic NMDARs and AMPARs in mediating alcohol-seeking responses induced by environmental stimuli and relapse behavior using four inducible mutant mouse lines lacking the glutamate receptor genes Grin1 or Gria1 in either DA transporter (DAT) or D1R-expressing neurons...
November 25, 2015: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/26471421/memantine-alters-striatal-plasticity-inducing-a-shift-of-synaptic-responses-toward-long-term-depression
#6
Maria Mancini, Veronica Ghiglieri, Vincenza Bagetta, Valentina Pendolino, Anna Vannelli, Fabrizio Cacace, Desireé Mineo, Paolo Calabresi, Barbara Picconi
Memantine is an open channel blocker that antagonizes NMDA receptors reducing the inappropriate calcium (Ca(2+)) influx occurring in presence of moderately increased glutamate levels. At the same time, memantine has the ability to preserve the transient physiological activation of NMDA receptor, essential for learning and memory formation at synaptic level. In the present study we investigated the effects exerted by memantine on striatal synaptic plasticity in rat striatal spiny projection neurons (SPNs). In vitro application of memantine in striatal slices elicited a disruption of long-term potentiation (LTP) induction and maintenance, and revealed, in the majority of the recorded neurons, a long-term depression (LTD), whose amplitude was concentration-dependent (0...
February 2016: Neuropharmacology
https://www.readbyqxmd.com/read/26449310/electrical-high-frequency-stimulation-modulates-gabaergic-activity-in-the-nucleus-accumbens-of-freely-moving-rats
#7
Ramya Varatharajan, Kevin Joseph, Sonya Carvalho Neto, Ulrich G Hofmann, Andreas Moser, Volker Tronnier
Deep brain stimulation (DBS) of the nucleus accumbens (NAc) is an effective treatment option for those affected by obsessive compulsive disorder, who do not respond to pharmacological treatment strategies. Yet, little is known about the mechanism by which DBS achieve its therapeutic effects. Previous studies have shown an increase in GABA levels due to high frequency stimulation (HFS) in the rat caudate putamen. Here, the effect of high frequency stimulation in the nucleus accumbens of conscious and freely moving rats was characterized using unilateral but simultaneous microdialysis and HFS with a frequency of 124 Hz and 0...
November 2015: Neurochemistry International
https://www.readbyqxmd.com/read/26447539/interventions-for-fatigue-in-parkinson-s-disease
#8
REVIEW
Roy G Elbers, John Verhoef, Erwin Eh van Wegen, Henk W Berendse, Gert Kwakkel
BACKGROUND: Factors contributing to subjective fatigue in people with idiopathic Parkinson's disease (PD) are not well known. This makes it difficult to manage fatigue effectively in PD. OBJECTIVES: To evaluate the effects of pharmacological and non-pharmacological interventions, compared to an inactive control intervention, on subjective fatigue in people with PD. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library); MEDLINE (via PubMed); Ovid EMBASE; EBSCO CINAHL; Ovid PsycINFO; PEDro; and the WHO International Clinical Trials Registry Platform Search Portal up to April 2015...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/25989606/low-dose-add-on-memantine-treatment-may-improve-cognitive-performance-and-self-reported-health-conditions-in-opioid-dependent-patients-undergoing-methadone-maintenance-therapy
#9
Yun-Hsuan Chang, Shiou-Lan Chen, Sheng-Yu Lee, Po See Chen, Tzu-Yun Wang, I Hui Lee, Kao Chin Chen, Yen Kuang Yang, Jau-Shyong Hong, Ru-Band Lu
An important interaction between opioid and dopamine systems has been indicated, and using opioids may negatively affect cognitive functioning. Memantine, a medication for Alzheimer's disease, increasingly is being used for several disorders and maybe important for cognitive improvement. Opioid-dependent patients undergoing methadone-maintenance-therapy (MMT) and healthy controls (HCs) were recruited. Patients randomly assigned to the experimental (5 mg/day memantine (MMT+M) or placebo (MMT+P) group: 57 in MMT+M, 77 in MMT+P...
2015: Scientific Reports
https://www.readbyqxmd.com/read/25988317/low-dose-memantine-attenuated-methadone-dose-in-opioid-dependent-patients-a-12-week-double-blind-randomized-controlled-trial
#10
RANDOMIZED CONTROLLED TRIAL
Sheng-Yu Lee, Shiou-Lan Chen, Yun-Hsuan Chang, Po See Chen, San-Yuan Huang, Nian-Sheng Tzeng, Liang-Jen Wang, I Hui Lee, Tzu-Yun Wang, Kao Chin Chen, Yen Kuang Yang, Jau-Shyong Hong, Ru-Band Lu
Low-dose memantine might have anti-inflammatory and neurotrophic effects mechanistically remote from an NMDA receptor. We investigated whether add-on memantine reduced cytokine levels and benefitted patients with opioid dependence undergoing methadone maintenance therapy (MMT) in a randomized, double-blind, controlled 12-week study. Patients were randomly assigned to a group: Memantine (5 mg/day) (n = 53) or Placebo (n = 75). The methadone dose required and retention in treatment were monitored. Plasma tumor necrosis factor (TNF)-α, C-reactive protein (CRP), interleukin (IL)-6, IL-8, transforming growth factor (TGF)-β1, and brain-derived neurotrophic factor (BDNF) levels were examined during weeks 0, 1, 4, 8, and 12...
2015: Scientific Reports
https://www.readbyqxmd.com/read/25942563/nmda-receptor-antagonist-attenuates-bleomycin-induced-acute-lung-injury
#11
Yang Li, Yong Liu, XiangPing Peng, Wei Liu, FeiYan Zhao, DanDan Feng, JianZhong Han, YanHong Huang, SiWei Luo, Lian Li, Shao Jie Yue, QingMei Cheng, XiaoTing Huang, ZiQiang Luo
BACKGROUND: Glutamate is a major neurotransmitter in the central nervous system (CNS). Large amount of glutamate can overstimulate N-methyl-D-aspartate receptor (NMDAR), causing neuronal injury and death. Recently, NMDAR has been reported to be found in the lungs. The aim of this study is to examine the effects of memantine, a NMDAR channel blocker, on bleomycin-induced lung injury mice. METHODS: C57BL/6 mice were intratracheally injected with bleomycin (BLM) to induce lung injury...
2015: PloS One
https://www.readbyqxmd.com/read/25837898/medical-management-of-patients-with-brain-tumors
#12
REVIEW
Amy A Pruitt
PURPOSE OF REVIEW: This review provides management recommendations for medical and neurologic problems in patients with brain tumors, including vasogenic edema, infections, seizures, prophylaxis and treatment of venous thromboembolism, drug interactions, cognitive and emotional problems, palliative symptom management, and long-term sequelae of brain tumors and their therapy. RECENT FINDINGS: Non-enzyme-inducing antiepileptic drugs are the preferred category of seizure medication for patients with brain tumors, and levetiracetam is emerging as the drug of choice...
April 2015: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/25661848/memantine-prevents-bipolar-like-behavior-induced-by-chronic-treatment-with-imipramine-in-rats
#13
Francesca Demontis, Marcella Falconi, Desirèe Canu, Gino Serra
A great deal of evidence suggests that virtually all antidepressant treatments induce a dopaminergic behavioral supersensitivity. We have suggested that this effect may play a key role not only in the antidepressant effect of these treatments, but also in their ability to induce a switch from depression to mania. In 2003-4 we found that the sensitization of dopamine receptors induced by imipramine is followed, after imipramine withdrawal, by a desensitization of these receptors associated with a depressive-like behavior assessed in the forced swimming test...
April 5, 2015: European Journal of Pharmacology
https://www.readbyqxmd.com/read/25656790/memantine-selectively-blocks-extrasynaptic-nmda-receptors-in-rat-substantia-nigra-dopamine-neurons
#14
Yan-Na Wu, Steven W Johnson
Recent studies suggest that selective block of extrasynaptic N-methyl-d-aspartate (NMDA) receptors might protect against neurodegeneration. We recorded whole-cell currents with patch pipettes to characterize the ability of memantine, a low-affinity NMDA channel blocker, to block synaptic and extrasynaptic NMDA receptors in substantia nigra zona compacta (SNC) dopamine neurons in slices of rat brain. Pharmacologically isolated NMDA receptor-mediated EPSCs were evoked by electrical stimulation, whereas synaptic and extrasynaptic receptors were activated by superfusing the slice with NMDA (10 µM)...
April 7, 2015: Brain Research
https://www.readbyqxmd.com/read/25624417/combination-therapy-of-cholinesterase-inhibitor-donepezil-or-galantamine-plus-memantine-in-the-okayama-memantine-study
#15
Kosuke Matsuzono, Nozomi Hishikawa, Yasuyuki Ohta, Toru Yamashita, Kentaro Deguchi, Yumiko Nakano, Koji Abe
BACKGROUND/OBJECTIVE: To compare the effectiveness of combination therapy with cholinesterase inhibitors (ChEI) plus memantine in all AD patients and in older AD patients (age >75 years). METHODS: The Okayama Memantine Study was used to compare the clinical effects of combination therapy of donepezil plus memantine (n = 61) or galantamine plus memantine (n = 53) in all AD patients, and in older AD patients separately, with six batteries at baseline, at 6 months with ChEI only monotherapy, and at 3, 6, and 12 months after addition of memantine to the treatment schedule (18 months total)...
2015: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/25540723/memantine-new-prospective-in-bipolar-disorder-treatment
#16
REVIEW
Giulia Serra, Francesca Demontis, Francesca Serra, Lavinia De Chiara, Andrea Spoto, Paolo Girardi, Giulio Vidotto, Gino Serra
UNLABELLED: We review preclinical and clinical evidences strongly suggesting that memantine, an old drug currently approved for Alzheimer's dementia, is an effective treatment for acute mania and for the prevention of manic/hypomanic and depressive recurrences of manic-depressive illness. Lithium remains the first line for the treatment and prophylaxis of bipolar disorders, but currently available treatment alternatives for lithium resistant patients are of limited and/or questionable efficacy...
December 22, 2014: World Journal of Psychiatry
https://www.readbyqxmd.com/read/25537279/company-s-attempt-to-switch-its-patients-to-a-new-drug-is-foiled
#17
Owen Dyer
No abstract text is available yet for this article.
2014: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/25523430/evaluating-high-dose-rivastigmine-patch-in-severe-alzheimer-s-disease-analyses-with-concomitant-memantine-usage-as-a-factor
#18
RANDOMIZED CONTROLLED TRIAL
George T Grossberg, Martin R Farlow, Xiangyi Meng, Drew M Velting
BACKGROUND: ACTION, a 24-week, prospective, randomized, parallel-group, double-blind study in patients with severe Alzheimer's disease (AD), demonstrated significant efficacy of 13.3 mg/24 h versus 4.6 mg/24 h rivastigmine patch on the Severe Impairment Battery (SIB) and Alzheimer's Disease Cooperative Study-Activities of Daily Living scale-Severe Impairment Version (ADCS-ADL-SIV). Overall, 61% of the study population received at least 1 dose of concomitant memantine, regardless of dose or duration...
2015: Current Alzheimer Research
https://www.readbyqxmd.com/read/25467702/ketamine-and-other-potential-glutamate-antidepressants
#19
REVIEW
Arpan Dutta, Shane McKie, J F William Deakin
The need for rapid acting antidepressants is widely recognised. There has been much interest in glutamate mechanisms in major depressive disorder (MDD) as a promising target for the development of new antidepressants. A single intravenous infusion of ketamine, a N-methyl-d-aspartate (NMDA) receptor antagonist anaesthetic agent, can alleviate depressive symptoms in patients within hours of administration. The mechanism of action appears to be in part through glutamate release onto non-NMDA receptors including α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and metabotropic receptors...
January 30, 2015: Psychiatry Research
https://www.readbyqxmd.com/read/25253860/differential-modulation-of-reinforcement-learning-by-d2-dopamine-and-nmda-glutamate-receptor-antagonism
#20
Gerhard Jocham, Tilmann A Klein, Markus Ullsperger
The firing pattern of midbrain dopamine (DA) neurons is well known to reflect reward prediction errors (PEs), the difference between obtained and expected rewards. The PE is thought to be a crucial signal for instrumental learning, and interference with DA transmission impairs learning. Phasic increases of DA neuron firing during positive PEs are driven by activation of NMDA receptors, whereas phasic suppression of firing during negative PEs is likely mediated by inputs from the lateral habenula. We aimed to determine the contribution of DA D2-class and NMDA receptors to appetitively and aversively motivated reinforcement learning...
September 24, 2014: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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