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Ankle brachial index and coronary artery disease

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https://www.readbyqxmd.com/read/29133605/low-density-lipoprotein-cholesterol-lowering-with-evolocumab-and-outcomes-in-patients-with-peripheral-artery-disease-insights-from-the-fourier-trial-further-cardiovascular-outcomes-research-with-pcsk9-inhibition-in-subjects-with-elevated-risk
#1
Marc P Bonaca, Patrice Nault, Robert P Giugliano, Anthony C Keech, Armando Lira Pineda, Estella Kanevsky, Julia Kuder, Sabina A Murphy, J Wouter Jukema, Basil S Lewis, Lale Tokgozoglu, Ransi Somaratne, Peter S Sever, Terje R Pedersen, Marc S Sabatine
BACKGROUND : The PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitor evolocumab reduced low-density lipoprotein cholesterol and cardiovascular events in the FOURIER trial (Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk). We investigated the efficacy and safety of evolocumab in patients with peripheral artery disease (PAD) as well as the effect on major adverse limb events. METHODS : FOURIER was a randomized trial of evolocumab versus placebo in 27 564 patients with atherosclerotic disease on statin therapy followed for a median of 2...
November 13, 2017: Circulation
https://www.readbyqxmd.com/read/29132880/rivaroxaban-with-or-without-aspirin-in-patients-with-stable-peripheral-or-carotid-artery-disease-an-international-randomised-double-blind-placebo-controlled-trial
#2
Sonia S Anand, Jackie Bosch, John W Eikelboom, Stuart J Connolly, Rafael Diaz, Peter Widimsky, Victor Aboyans, Marco Alings, Ajay K Kakkar, Katalin Keltai, Aldo P Maggioni, Basil S Lewis, Stefan Störk, Jun Zhu, Patricio Lopez-Jaramillo, Martin O'Donnell, Patrick J Commerford, Dragos Vinereanu, Nana Pogosova, Lars Ryden, Keith A A Fox, Deepak L Bhatt, Frank Misselwitz, John D Varigos, Thomas Vanassche, Alvaro A Avezum, Edmond Chen, Kelley Branch, Darryl P Leong, Shrikant I Bangdiwala, Robert G Hart, Salim Yusuf
BACKGROUND: Patients with peripheral artery disease have an increased risk of cardiovascular morbidity and mortality. Antiplatelet agents are widely used to reduce these complications. METHODS: This was a multicentre, double-blind, randomised placebo-controlled trial for which patients were recruited at 602 hospitals, clinics, or community practices from 33 countries across six continents. Eligible patients had a history of peripheral artery disease of the lower extremities (previous peripheral bypass surgery or angioplasty, limb or foot amputation, intermittent claudication with objective evidence of peripheral artery disease), of the carotid arteries (previous carotid artery revascularisation or asymptomatic carotid artery stenosis of at least 50%), or coronary artery disease with an ankle-brachial index of less than 0·90...
November 10, 2017: Lancet
https://www.readbyqxmd.com/read/28976393/-approach-to-peripheral-arterial-disease-in-the-elderly
#3
Ozan Onur Balkanay, Suat Nail Ömeroğlu
The prevalence of peripheral arterial disease, which usually develops on the basis of atherosclerosis and develops as a result of chronic arterial occlusive pathology, increases with age. Peripheral artery disease in the elderly patient population may be asymptomatic due to restrictive conditions associated with immobilization. Concurrent cerebrovascular disease and coronary artery disease risk and mortality rates are higher in elderly patients with peripheral artery disease. The life expectancy in patients with peripheral arterial disease is worse than in prostate cancer patients...
September 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28956475/prognostic-value-of-ankle-brachial-index-in-patients-undergoing-percutaneous-coronary-intervention-in-hospital-and-1-year-outcomes-from-the-shinano-registry
#4
Naoto Hashizume, Takashi Miura, Yusuke Miyashita, Hirohiko Motoki, Soichiro Ebisawa, Atsushi Izawa, Jun Koyama, Uichi Ikeda, Koichiro Kuwahara
Concomitant coronary and peripheral artery disease is associated with higher periprocedural and long-term percutaneous coronary intervention (PCI) complication rates. We evaluated in-hospital and 1-year clinical outcomes of patients with low or borderline ankle-brachial indexes (ABIs) undergoing PCIs in the drug-eluting stent era. We divided 1370 SHINANO registry patients into 3 groups-low (ABI ≤ 0.9), borderline (0.9 < ABI ≤ 1.0), and normal (1.0 ≤ ABI < 1.4). During the 1-year follow-up, more PCI-related complications occurred in the low and borderline ABI groups than in the normal ABI group (7...
November 2017: Angiology
https://www.readbyqxmd.com/read/28950166/leukocyte-telomere-length-and-cardiovascular-disease-in-african-americans-the-jackson-heart-study
#5
Stanford Mwasongwe, Yan Gao, Michael Griswold, James G Wilson, Abraham Aviv, Alexander P Reiner, Laura M Raffield
BACKGROUND AND AIMS: In European descent populations, shorter leukocyte telomere length (LTL) has been associated with subclinical atherosclerosis, cardiovascular disease (CVD), and mortality, while longer LTL has been associated with greater left ventricular hypertrophy. We evaluated the relationship of LTL with subclinical cardiovascular disease indices and incident clinical events and mortality in African Americans (AAs). METHODS: Analyses were restricted to 2518 participants of the Jackson Heart Study (JHS) with LTL measured by Southern blot in baseline blood samples...
November 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28915894/cardiovascular-risk-in-patients-with-alpha-1-antitrypsin-deficiency
#6
Sebastian Fähndrich, Frank Biertz, Annika Karch, Björn Kleibrink, Armin Koch, Helmut Teschler, Tobias Welte, Hans-Ulrich Kauczor, Sabina Janciauskiene, Rudolf A Jörres, Timm Greulich, Claus F Vogelmeier, Robert Bals
BACKGROUND: Alpha-1-antitrypsin deficiency (AATD) is a rare inherited condition caused by mutations of the SERPINA1 gene that is associated with the development of a COPD like lung disease. The comorbidities in patients with AATD-related lung diseases are not well defined. The aim of this study was to analyze the clinical phenotype of AATD patients within the German COPD cohort study COSYCONET ("COPD and SYstemic consequences-COmorbidities NETwork") cohort focusing on the distribution of comorbidities...
September 15, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28838085/long-term-survival-and-fate-of-the-leg-in-de-novo-intermittent-claudication
#7
Hisao Kumakura, Hiroyoshi Kanai, Yoshiaki Hojo, Toshiya Iwasaki, Shuichi Ichikawa
Aims: The long-term life expectancy and fate of the leg, including progression rate to critical limb ischaemia (CLI), were analysed in de novo patients with intermittent claudication (IC). Methods and results: A prospective cohort study was performed in 1107 patients with de novo IC. The endpoints were overall survival (OS), freedom from major adverse cardiovascular events (MACE), freedom from major adverse cardiovascular and limb events (MACLE), and fate of the leg...
July 1, 2017: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/28835113/endothelial-cell-inflammation-and-antioxidant-capacity-are-associated-with-6-minute-walk-performance-in-patients-with-symptomatic-peripheral-artery-disease
#8
Andrew W Gardner, Polly S Montgomery, Yan D Zhao, Zoltan Ungvari, Anna Csiszar, William E Sonntag
We determined whether 6-minute walk total distance and pain-free distance were associated with circulating biomarkers of antioxidant capacity and inflammation and with cultured endothelial cell inflammation, oxidative stress, and apoptosis in 251 patients with symptomatic peripheral artery disease (PAD). In multivariate analyses, pain-free distance during the 6-minute walk test was negatively associated with dyslipidemia ( P < .001), chronic kidney disease ( P = .004), and transient transfection, nuclear factor κ-Light-Chain-Enhancer of activated B (NF-κB) cultured endothelial cells ( P = ...
January 1, 2017: Angiology
https://www.readbyqxmd.com/read/28803825/cardiovascular-events-after-exposure-to-nilotinib-in-chronic-myeloid-leukemia-long-term-follow-up
#9
Nazanin Aghel, Jeffrey Howard Lipton, Eshetu G Atenafu, Dennis Dong Hwan Kim, Diego Hernan Delgado
INTRODUCTION: Nilotinib is a highly effective tyrosine kinase inhibitor in the treatment of chronic myeloid leukemia (CML). However, reports of cardiovascular toxicities caused by nilotinib have recently raised critical concerns. The aim of the present study was to evaluate the incidence of cardiovascular events (CVEs) and frequency of asymptomatic peripheral arterial disease (PAD) after long-term exposure to nilotinib. PATIENTS AND METHODS: In the present retrospective cohort, we evaluated the incidence of CVEs in 63 CML patients treated with nilotinib...
July 15, 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/28794054/cardiovascular-event-prediction-by-machine-learning-the-multi-ethnic-study-of-atherosclerosis
#10
RANDOMIZED CONTROLLED TRIAL
Bharath Ambale-Venkatesh, Xiaoying Yang, Colin O Wu, Kiang Liu, W Gregory Hundley, Robyn McClelland, Antoinette S Gomes, Aaron R Folsom, Steven Shea, Eliseo Guallar, David A Bluemke, João A C Lima
RATIONALE: Machine learning may be useful to characterize cardiovascular risk, predict outcomes, and identify biomarkers in population studies. OBJECTIVE: To test the ability of random survival forests, a machine learning technique, to predict 6 cardiovascular outcomes in comparison to standard cardiovascular risk scores. METHODS AND RESULTS: We included participants from the MESA (Multi-Ethnic Study of Atherosclerosis). Baseline measurements were used to predict cardiovascular outcomes over 12 years of follow-up...
October 13, 2017: Circulation Research
https://www.readbyqxmd.com/read/28696562/association-between-nonalcoholic-fatty-liver-disease-and-peripheral-artery-disease-in-patients-with-type-2-diabetes
#11
Yaowu Zou, Xinde Li, Can Wang, Jing Wang, Fei Wang, Lidan Ma, Wenjun You, Changgui Li
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is associated with risk of coronary heart diseases; however, the relationship between NAFLD and peripheral artery disease (PAD) in patients with type 2 diabetes has not been investigated. AIMS: To investigate the association between NAFLD and PAD in patients with type 2 diabetes patients. METHODS: We carried out a cross-sectional study in 2646 type 2 diabetes patients ≥ 40 years...
July 11, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28681124/toe-brachial-index-as-a-predictor-of-cardiovascular-disease-and-all-cause-mortality-in-people-with-type-2-diabetes-and-microalbuminuria
#12
Emilie H Zobel, Bernt Johan von Scholten, Henrik Reinhard, Frederik Persson, Tine W Hansen, Hans-Henrik Parving, Peter K Jacobsen, Peter Rossing
AIMS/HYPOTHESIS: The study aimed to evaluate toe-brachial index (TBI) and ankle-brachial index (ABI) as determinants of incident cardiovascular disease (CVD) and all-cause mortality in people with type 2 diabetes and microalbuminuria. METHODS: This was a prospective study including 200 participants. Unadjusted and adjusted (traditional risk factors and additional inclusion of N-terminal pro-brain natriuretic peptide [NT-proBNP] and coronary artery calcification) Cox regression models were performed...
October 2017: Diabetologia
https://www.readbyqxmd.com/read/28666027/hyperuricemia-and-risk-of-increased-arterial-stiffness-in-healthy-women-based-on-health-screening-in-korean-population
#13
Hoon Young Choi, Seok-Hyung Kim, Ah Ran Choi, Seung Gyu Kim, Hyunwook Kim, Jung Eun Lee, Hyung Jong Kim, Hyeong Cheon Park
Hyperuricemia is a risk factor for cardiovascular disease and is associated with increased arterial stiffness in high-risk populations. However, given the possible sex-related differences in the prevalence of hyperuricemia, the association between elevated serum uric acid (SUA) level and increased arterial stiffness has yielded conflicting results. We investigated the relationship between SUA and arterial stiffness in asymptomatic healthy subjects who underwent a health examination. Subjects who underwent a comprehensive health examination were enrolled...
2017: PloS One
https://www.readbyqxmd.com/read/28647689/associations-of-cigarette-smoking-with-subclinical-inflammation-and-atherosclerosis-elsa-brasil-the-brazilian-longitudinal-study-of-adult-health
#14
Sina Kianoush, Mohammad Yawar Yakoob, Mahmoud Al-Rifai, Andrew P DeFilippis, Marcio S Bittencourt, Bruce B Duncan, Isabela M Bensenor, Aruni Bhatnagar, Paulo A Lotufo, Michael J Blaha
BACKGROUND: There is a need to identify sensitive biomarkers of early tobacco-related cardiovascular disease. We examined the association of smoking status, burden, time since quitting, and intensity, with markers of inflammation and subclinical atherosclerosis. METHODS AND RESULTS: We studied 14 103 participants without clinical cardiovascular disease in ELSA-Brasil (Brazilian Longitudinal Study of Adult Health). We evaluated baseline cross-sectional associations between smoking parameters and inflammation (high-sensitivity C-reactive protein [hsCRP]) and measures of subclinical atherosclerosis (carotid intima-media thickness, ankle-brachial index, and coronary artery calcium [CAC])...
June 24, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28607554/lower-extremity-peripheral-arterial-disease-is-an-independent-predictor-of-coronary-heart-disease-and-stroke-risks-in-patients-with-type-2-diabetes-mellitus-in-china
#15
Xiao-Hong Pang, Jue Han, Wan-Lan Ye, Xue Sun, Yue Ding, Wen-Juan Huang, Yi-Ming Zhao, Han-Yu Lou, Li-Zhen Shan, Ying-Xiu Kang, Xiao-Xiao Song, Song-Zhao Zhang, Wei Gu, Peng-Fei Shan
We aimed to determine the relationship between lower extremity peripheral arterial disease (PAD), 10-year coronary heart disease (CHD), and stroke risks in patients with type 2 diabetes (T2DM) using the UKPDS risk engine. We enrolled 1178 hospitalized T2DM patients. The patients were divided into a lower extremity PAD group (ankle-brachial index ≤ 0.9 or >1.4; 88 patients, 7.5%) and a non-PAD group (ankle-brachial index > 0.9 and ≤1.4; 1090 patients, 92.5%). Age; duration of diabetes; systolic blood pressure; the hypertension rate; the use of hypertension drugs, ACEI /ARB, statins; CHD risk; fatal CHD risk; stroke risk; and fatal stroke risk were significantly higher in the PAD group than in the non-PAD group (P < 0...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28599258/prognostic-impact-of-subclinical-or-manifest-extracoronary-artery-diseases-after-acute-myocardial-infarction
#16
Maja Eriksson Östman, Fredrik Calais, Andreas Rosenblad, Ole Fröbert, Jerzy Leppert, Pär Hedberg
BACKGROUND AND AIMS: In patients with coronary artery disease (CAD), clinically overt extracoronary artery diseases (ECADs), including claudication or previous strokes, are associated with poor outcomes. Subclinical ECADs detected by screening are common among such patients. We aimed to evaluate the prognostic impact of subclinical versus symptomatic ECADs in patients with acute myocardial infarction (AMI). METHODS: In a prospective observational study, 654 consecutive patients diagnosed with AMI underwent ankle brachial index (ABI) measurements and ultrasonographic screening of the carotid arteries and abdominal aorta...
May 26, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28598042/peripheral-vascular-disease-in-patients-with-diabetic-foot-ulcers-an-emerging-trend-a-prospective-study-from-north-india
#17
Supriya Bajaj, Amit Mahajan, Sumit Grover, Vijay Mahajan, Pankaj Goyal, Vikram Kumar Gupta
BACKGROUND: Diabetic foot ulcer is one of the chronic complications of diabetes mellitus (DM) with 25% of patients with diabetes developing a foot ulcer during their lifetime leading to amputation. Diabetic foot is classified into 2 main types: neuropathic ulcers (NPU) and neuro-ischemic ulcer (NIU) where in addition to neuropathy peripheral vascular disease (PVD) is also present. AIMS: We aimed to a) assess the prevalence of Peripheral vascular disease (PVD) in patients of type 2 diabetes mellitus (T2DM) presenting with New Diabetic Foot ulcers (DFU)...
May 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28582505/subclinical-cardiovascular-disease-and-changes-in-self-reported-mobility-multi-ethnic-study-of-atherosclerosis-mesa
#18
Susan A Everson-Rose, Carlos F Mendes de Leon, Nicholas S Roetker, Pamela L Lutsey, Alvaro Alonso
BACKGROUND.: We examined associations of three markers of subclinical cardiovascular disease (CVD) (intimal-medial thickening (IMT); coronary artery calcification (CAC); and ankle-brachial index (ABI)) with changes in self-reported walking over time. METHODS.: Data were from 6,490 MESA participants (aged 45-84 years), free of clinical CVD at baseline. Outcomes, assessed four times over 11 years, included self-reported walking pace (none to striding pace; score, 0-4), and total walking time (minutes/week)...
June 3, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28559662/the-relationship-between-brachial-ankle-pulse-wave-velocity-and-depressive-symptoms-among-patients-with-coronary-artery-disease
#19
I-Mei Lin, Hsueh-Chen Lu, Chih-Sheng Chu, Chee-Siong Lee, Ye-Hsu Lu, Tsung-Hsien Lin
BACKGROUND: Noninvasive brachial-ankle pulse wave velocity (baPWV) is an index for arterial stiffness in coronary artery disease (CAD). Depression has been connected to increased adverse cardiac events and mortality among patients with CAD. The aim of this study was to investigate the relationship between arterial stiffness and depressive symptoms among patients with CAD. METHODS: Eighty-six patients with CAD were recruited. Demographic characteristics and Beck Depressive Inventory II scores were obtained from the study participants, and resting baPWV was measured by using a noninvasive device...
May 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/28545441/association-between-antibodies-to-carbamylated-proteins-and-subclinical-atherosclerosis-in-rheumatoid-arthritis-patients
#20
Francesca Romana Spinelli, Arbi Pecani, Francesco Ciciarello, Tania Colasanti, Manuela Di Franco, Francesca Miranda, Fabrizio Conti, Guido Valesini, Cristiano Alessandri
BACKGROUND: Rheumatoid arthritis (RA) patients carry a high risk of cardiovascular morbidity and mortality. The excess of cardiovascular disease cannot be entirely explained by traditional risk factors and the immune system contributes to the development of atherosclerosis. Moreover, post-translational modifications such as citrullination and carbamylation have been linked to inflammation and atherosclerosis. Anti-carbamylated proteins antibodies (anti-CarP) are a new subset of autoantibodies identified in RA patients...
May 25, 2017: BMC Musculoskeletal Disorders
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