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Gestational diabete

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https://www.readbyqxmd.com/read/28086820/primary-prevention-of-gestational-diabetes-mellitus-through-nutritional-factors-a-systematic-review
#1
Mikel Donazar-Ezcurra, Cristina López-Del Burgo, Maira Bes-Rastrollo
BACKGROUND: Gestational diabetes mellitus (GDM), defined as any degree of glucose intolerance with onset during pregnancy, is increasing worldwide, mostly because obesity among women of reproductive age is continuously escalating. GDM is associated with adverse maternal and fetal outcomes. The aim of this article was to systematically review literature on the effectiveness of nutritional factors before or during pregnancy to prevent GDM. METHODS: We assessed the primary prevention of GDM through nutritional factors, as diet and supplements...
January 13, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28081192/circulating-betatrophin-levels-and-gestational-diabetes-mellitus-a-systematic-review-and-meta-analysis
#2
Fei-Juan Kong, Lei-Lei Ma, Ge Li, Yi-Xin Chen, Jia-Qiang Zhou
OBJECTIVE: The association between circulating betatrophin levels and gestational diabetes mellitus (GDM) is controversial. The aim of our study was to systematically review available literature linking betatrophin to GDM for a comprehensive understanding of the relationship between circulating betatrophin levels and GDM in human. METHODS: PubMed, The Cochrane Library, Medline and CNKI were searched for studies published up to August 2016. Manual searches of references of the relevant original studies were conducted...
2017: PloS One
https://www.readbyqxmd.com/read/28080219/adipose-tissue-insulin-resistance-in-gestational-diabetes
#3
Batbayar Tumurbaatar, Aaron T Poole, Gayle Olson, Michel Makhlouf, Hanaa S Sallam, Shwetha Thukuntla, Sucharitha Kankanala, Obos Ekhaese, Guillermo Gomez, Manisha Chandalia, Nicola Abate
BACKGROUND: Gestational diabetes mellitus (GDM) is a metabolic disorder characterized by insulin resistance (IR) and altered glucose-lipid metabolism. We propose that ectonucleotide pyrophosphate phosphodiesterase-1 (ENPP1), a protein known to induce adipocyte IR, is a determinant of GDM. Our objective was to study ENPP1 expression in adipose tissue (AT) of obese pregnant women with or without GDM, as well as glucose tolerance in pregnant transgenic (Tg) mice with AT-specific overexpression of human ENPP1...
January 12, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28079868/cdc123-camk1d-gene-rs12779790-polymorphism-and-rs10811661-polymorphism-upstream-of-the-cdkn2a-2b-gene-in-women-with-gestational-diabetes
#4
M Tarnowski, D Malinowski, K Safranow, V Dziedziejko, A Pawlik
OBJECTIVE: Gestational diabetes mellitus (GDM) is carbohydrate intolerance occurring in pregnant women. CDC123/CAMK1D and CDKN2A/2B are associated with increased risk of type 2 diabetes and may affect pancreatic beta cell function. The aim of this study was to examine the association between CDKN2A/2B rs10811661 and CDC123/CAMK1D rs12779790 gene polymorphisms and GDM. STUDY DESIGN: This study included 411 pregnant women. The diagnosis of GDM was based on the International Association of Diabetes and Pregnancy Study Groups criteria...
January 12, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28079866/outcomes-of-twin-pregnancies-complicated-by-gestational-diabetes-a-meta-analysis-of-observational-studies
#5
R T McGrath, S L Hocking, E S Scott, S K Seeho, G R Fulcher, S J Glastras
OBJECTIVE: Gestational diabetes mellitus (GDM) in singleton pregnancy is associated with large for gestational age neonates and adverse perinatal outcomes; however, the impact of GDM in twin pregnancy is unclear. Thus, the aim of this study is to assess the perinatal outcomes of twin pregnancies complicated by GDM by performing a meta-analysis of observational studies. STUDY DESIGN: Studies investigating GDM in twin pregnancy were identified through an online search of three databases: Medline, Embase and Web of Science...
January 12, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28079773/pregnancies-after-the-diagnosis-of-mild-gestational-diabetes-mellitus-and-risk-of-cardiometabolic-disorders
#6
Michael W Varner, Madeline Murguia Rice, Mark B Landon, Brian M Casey, Uma M Reddy, Ronald J Wapner, Dwight J Rouse, Alan T N Tita, John M Thorp, Edward K Chien, George R Saade, Alan M Peaceman, Sean C Blackwell, J Peter Vandorsten
OBJECTIVE: To assess the association of subsequent pregnancy with subsequent metabolic syndrome and type II diabetes mellitus after a pregnancy complicated by mild gestational diabetes mellitus (GDM). METHODS: We conducted a prospective observational follow-up study of women with mild GDM randomized from 2002 to 2007 to usual care or dietary intervention and glucose self-monitoring. Women were evaluated 5-10 years after the parent study. Participants were grouped according to the number of subsequent pregnancies (group A, none [reference]; group B, one; group C, two or greater)...
January 9, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28079766/attempted-and-successful-vacuum-assisted-vaginal-delivery-by-prepregnancy-body-mass-index
#7
Sebastian Z Ramos, Molly E Waring, Katherine Leung, Nili S Amir, Annika L Bannon, Tiffany A Moore Simas
OBJECTIVE: To examine rates of attempted and successful vacuum-assisted vaginal delivery by prepregnancy body mass index (BMI). METHODS: We conducted a retrospective cohort study of 2,084 women with singleton gestations needing operative delivery assistance and vacuum-eligible (fully dilated, +2 station or greater, 34 weeks of gestation or greater) using 2006-2014 inpatient records. Prepregnancy BMI was categorized as underweight (less than 18.5), normal weight (18...
January 9, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28078553/expression-of-apoptosis-regulatory-genes-in-the-hippocampus-of-rat-neonates-born-to-mothers-with-diabetes
#8
Hossein Haghir, Javad Hami, Nassim Lotfi, Mostafa Peyvandi, Simagol Ghasemi, Mehran Hosseini
Diabetes during pregnancy impairs the development of the central nervous system (CNS) and causes cognitive and behavioral abnormalities in offspring. However, the exact mechanism by which the maternal diabetes affects the development of the brain remains to be elucidated. The aim of the present study was to investigate the effects of maternal diabetes in pregnancy on the expression of Bcl-2 and Bax genes and the numerical density of degenerating dark neurons (DNs) in the hippocampus of offspring at the first postnatal two weeks...
January 11, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28077460/glyburide-versus-metformin-and-their-combination-for-the-treatment-of-gestational-diabetes-mellitus-a-randomized-controlled-study
#9
Zohar Nachum, Noah Zafran, Raed Salim, Noura Hissin, Jamal Hasanein, Yifat Gam Ze Letova, Abeer Suleiman, Enav Yefet
OBJECTIVE: To compare the efficacy and safety of glyburide versus metformin and their combination for the treatment of gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS: In this prospective randomized controlled study, we randomly assigned patients with GDM at 13-33 weeks gestation and whose blood glucose was poorly controlled by diet to receive either glyburide or metformin. If optimal glycemic control was not achieved, the other drug was added. If adverse effects occurred, the drug was replaced...
January 11, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28076942/prevalence-of-gestational-diabetes-mellitus-in-a-suburban-district-in-sri-lanka-a-population-based-study
#10
B H Sudasinghe, P S Ginige, C N Wijeyaratne
Introduction: GDM is a leading metabolic cause of morbidity to mother and offspring. Determining its prevalence is important for health planning and implementation. Objective: Assess prevalence of GDM in the District of Gampaha. Method: Community based cross-sectional study was conducted in women attending field-based ante-natal clinics in two Medical Officer of Health (MOH) areas between January 2014 to March 2015. Consecutive women were recruited by cluster sampling with probability proportionate to size using strict exclusion criteria...
30, 2016: Ceylon Medical Journal
https://www.readbyqxmd.com/read/28074994/-normoglycemic-diabetic-ketoacidosis-in-pregnancy-report-of-one-case
#11
Margarita Rivas M, Pamela Belmar Z, Pilar Durruty A, Lilian Sanhueza M, Gloria López S
Normoglycemic diabetic ketoacidosis should be suspected in pregnant women presenting nausea, vomiting, abdominal pain and anorexia. We report a 39 years old woman with a 32 weeks pregnancy who sought emergency care due to hyperemesis. She was hospitalized with the following diagnoses: pregnancy hypertension syndrome, gestational diabetes, morbid obesity and poor prenatal control. The evaluation of the feto-placental unit showed perception of fetal movements, non-reactive non-stress baseline record and a biophysical profile of 6/8...
October 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/28073830/adiponectin-deficiency-impairs-maternal-metabolic-adaptation-to-pregnancy-in-mice
#12
Liping Qiao, Jean-Sebastien Wattez, Samuel Lee, Amanda Nguyen, Jerome Schaack, William W Hay, Jianhua Shao
Hypoadiponectinemia has been widely observed in patients with gestational diabetes. To investigate the causal role of hypoadiponectinemia in gestational diabetes, adiponectin gene knockout (Adipoq(-/-)) and wild-type (WT) mice were crossed to produce pregnant mouse models with or without adiponectin deficiency. Adenoviral vector-mediated in vivo transduction was used to reconstitute adiponectin during late pregnancy. Results showed that Adipoq(-/-) dams developed glucose intolerance and hyperlipidemia in late pregnancy...
January 10, 2017: Diabetes
https://www.readbyqxmd.com/read/28072911/potential-protective-effect-of-lactation-against-incidence-of-type-2-diabetes-in-women-with-previous-gestational-diabetes-mellitus-a-systematic-review-and-meta-analysis
#13
REVIEW
Kanako Tanase-Nakao, Naoko Arata, Maki Kawasaki, Ichiro Yasuhi, Hirohito Sone, Rintaro Mori, Erika Ota
BACKGROUND: Lactation may protect women with previous gestational diabetes mellitus (GDM) from developing type 2 diabetes, but the results of existing studies are inconsistent, ranging from null to beneficial. We aimed to conduct a systematic review to gather available evidence. METHODS: Databases MEDLINE, CINAHL, PubMed and EMBASE were searched on 15 December 2015 without restriction of language or publication year. A manual search was also conducted. We included observational studies (cross-sectional, case-control and cohort study) with information on lactation and type 2 diabetes incidence among women with previous GDM...
January 10, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28072873/association-study-with-77-snps-confirms-the-robust-role-for-the-rs10830963-g-of-mtnr1b-variant-and-identifies-two-novel-associations-in-gestational-diabetes-mellitus-development
#14
Klara Rosta, Zahra Al-Aissa, Orsolya Hadarits, Jürgen Harreiter, Ákos Nádasdi, Fanni Kelemen, Dagmar Bancher-Todesca, Zsolt Komlósi, László Németh, János Rigó, István Sziller, Anikó Somogyi, Alexandra Kautzky-Willer, Gábor Firneisz
CONTEXT: Genetic variation in human maternal DNA contributes to the susceptibility for development of gestational diabetes mellitus (GDM). OBJECTIVE: We assessed 77 maternal single nucleotide gene polymorphisms (SNPs) for associations with GDM or plasma glucose levels at OGTT in pregnancy. METHODS: 960 pregnant women (after dropouts 820: case/control: m99'WHO: 303/517, IADPSG: 287/533) were enrolled in two countries into this case-control study...
2017: PloS One
https://www.readbyqxmd.com/read/28069720/pregnancy-increases-the-renal-secretion-of-n1-methylnicotinamide-an-endogenous-probe-for-renal-cation-transporters-in-patients-prescribed-metformin
#15
Mackenzie C Bergagnini-Kolev, Mary F Hebert, Thomas R Easterling, Yvonne S Lin
N1-methylnicotinamide (1-NMN) has been investigated as an endogenous probe for the renal transporter activity of organic cation transporter 2 (OCT2) and multidrug and toxin extrusion proteins 1 and 2-K (MATE1 and MATE2-K). As pregnancy increased the renal secretion of metformin, a substrate for OCT2, MATE1 and MATE2-K, we hypothesized that the renal secretion of 1-NMN would be similarly affected. Blood and urine samples collected from women prescribed metformin for type 2 diabetes, gestational diabetes and polycystic ovarian syndrome (PCOS) during early-, mid-, and late-pregnancy (n = 34 visits) and postpartum (n=14 visits) were analyzed for 1-NMN using liquid chromatography-mass spectrometry...
January 9, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28068986/leptin-and-adiponectin-as-predictors-of-cardiovascular-risk-after-gestational-diabetes-mellitus
#16
Tove Lekva, Annika Elisabet Michelsen, Pål Aukrust, Tore Henriksen, Jens Bollerslev, Thor Ueland
BACKGROUND: Gestational diabetes mellitus (GDM) is a significant risk factor for cardiovascular disease (CVD) in later life, but the mechanism remains unclear. Adipokine imbalance in the presence of metabolic dysfunction may be a key event in promoting CVD. The aim of the study was to examine the relationships between GDM, cardiovascular risk, and plasma adiponectin, leptin and the leptin/adiponectin (L/A) ratio in pregnancy and at 5 years after the index pregnancy. METHODS: This population-based prospective cohort included 300 women who had an oral glucose tolerance test (OGTT) during pregnancy...
January 10, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28068927/subgroup-identification-of-early-preterm-birth-eptb-informing-a-future-prospective-enrichment-clinical-trial-design
#17
Chuanwu Zhang, Lili Garrard, John Keighley, Susan Carlson, Byron Gajewski
BACKGROUND: Despite the widely recognized association between the severity of early preterm birth (ePTB) and its related severe diseases, little is known about the potential risk factors of ePTB and the sub-population with high risk of ePTB. Moreover, motivated by a future confirmatory clinical trial to identify whether supplementing pregnant women with docosahexaenoic acid (DHA) has a different effect on the risk subgroup population or not in terms of ePTB prevalence, this study aims to identify potential risk subgroups and risk factors for ePTB, defined as babies born less than 34 weeks of gestation...
January 10, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28065256/a-newborn-infant-with-oxygen-desaturation-during-sleep
#18
Ashley Deschamp, Ameet Daftary
The patient is a 1-week-old boy born at 37+2 weeks' gestational age through spontaneous vaginal delivery. The pregnancy was complicated by maternal gestational diabetes mellitus and pre-eclampsia. The Apgar score was 9 at both 1 minute and 5 minutes after birth. Because of hypoglycemia at delivery that required IV dextrose, he was admitted to the local neonatal intensive care unit. His blood glucose levels quickly stabilized, dextrose administration was discontinued, and the patient began breast-feeding. On day 2 of life, the patient began having intermittent oxygen desaturation, with oxygen saturation as measured by pulse oximetry down to 70% while sleeping; he was transferred to a tertiary-care NICU for further management...
January 2017: Chest
https://www.readbyqxmd.com/read/28061829/patterns-of-gestational-diabetes-diagnosis-inside-and-outside-of-clinical-guidelines
#19
Jacinda M Nicklas, Chloe A Zera, Janet Lui, Ellen W Seely
BACKGROUND: Hospital discharge codes are often used to determine the incidence of gestational diabetes mellitus (GDM) at state and national levels. Previous studies demonstrate substantial variability in the accuracy of GDM reporting, and rarely report how the GDM was diagnosed. Our aim was to identify deliveries coded as gestational diabetes, and then to determine how the diagnosis was assigned and whether the diagnosis followed established guidelines. METHODS: We identified which deliveries were coded at discharge as complicated by GDM at the Brigham and Women's Hospital in Boston, MA for the year 2010...
January 6, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28057322/the-assessment-of-fetal-brain-growth-in-diabetic-pregnancy-using-in-utero-magnetic-resonance-imaging
#20
M Paddock, R Akram, D A Jarvis, P Armitage, S Song, P Madhuvrata, P D Griffiths
AIM: To assess fetal brain growth over the third trimester in pregnant women with diabetes using in utero magnetic resonance imaging (iuMRI) to determine if greater brain growth occurs in type 1 (T1DM) when compared to gestational (GDM) diabetes mellitus. MATERIALS AND METHODS: Each consented participant was scanned at three fixed times during the third trimester using iuMRI. One hundred and fifty-seven patients were approached, 48 participants were recruited, and 36 complete data sets were analysed...
January 3, 2017: Clinical Radiology
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