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https://www.readbyqxmd.com/read/28646272/rhesus-cochlear-and-vestibular-functions-are-preserved-after-inner-ear-injection-of-saline-volume-sufficient-for-gene-therapy-delivery
#1
Chenkai Dai, Mohamed Lehar, Daniel Q Sun, Lani Swarthout Rvt, John P Carey, Tim MacLachlan, Doug Brough, Hinrich Staecker, Alexandra M Della Santina, Timothy E Hullar, Charles C Della Santina
Sensorineural losses of hearing and vestibular sensation due to hair cell dysfunction are among the most common disabilities. Recent preclinical research demonstrates that treatment of the inner ear with a variety of compounds, including gene therapy agents, may elicit regeneration and/or repair of hair cells in animals exposed to ototoxic medications or other insults to the inner ear. Delivery of gene therapy may also offer a means for treatment of hereditary hearing loss. However, injection of a fluid volume sufficient to deliver an adequate dose of a pharmacologic agent could, in theory, cause inner ear trauma that compromises functional outcome...
June 23, 2017: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/28643681/-magnetic-resonance-neurography-for-the-identification-of-pudendal-neuralgia
#2
Claudia P Cejas, Susana Bordegaray, Nadia I Stefanoff, Cecilia Rollán, Inés T Escobar, Pablo Consigliere Rodríguez
The pudendal nerve entrapment is an entity understudied by diagnosis imaging. Various causes are recognized in relation to difficult labors, rectal, perineal, urological and gynecological surgery, pelvic trauma fracture, bones tumors and compression by tumors or pelvic pseudotumors. Pudendal neuropathy should be clinically suspected, and confirmed by different methods such as electrofisiological testing: evoked potentials, terminal motor latency test and electromyogram, neuronal block and magnetic resonance imaging...
2017: Medicina
https://www.readbyqxmd.com/read/28633121/biomaterials-based-strategies-for-rotator-cuff-repair
#3
REVIEW
Song Zhao, Wei Su, Vishva Shah, Divia Hobson, Lara Yildirimer, Kelvin W K Yeung, Jinzhong Zhao, Wenguo Cui, Xin Zhao
Tearing of the rotator cuff commonly occurs as among one of the most frequently experienced tendon disorders. While treatment typically involves surgical repair, failure rates to achieve or sustain healing range from 20 to 90%. The insufficient capacity to recover damaged tendon to heal to the bone, especially at the enthesis, is primarily responsible for the failure rates reported. Various types of biomaterials with special structures have been developed to improve tendon-bone healing and tendon regeneration, and have received considerable attention for replacement, reconstruction, or reinforcement of tendon defects...
June 6, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28631670/-topographic-anatomy-of-the-hook-region-and-its-significance-for-the-choice-of-the-surgical-technique-for-the-cochlear-implantation
#4
Yu K Yanov, V E Kuzovkov, A S Lilenko, I V Kostevich, S B Sugarova, A Sh Amonov
The mode of the introduction of the active electrode of a cochlear implant into the cochlea remains a key issue as far as cochlear implantation is concerned. Especially much attention has recently been given to the relationship between the anatomical features of the basal region of the cochlea (the so-called 'fish hook') and the possibility to approach it. We have undertaken the attempt to optimize the approach to the tympanic canal (scala tympanica) of the cochlea with a view to reducing to a minimum the risk of an injury to the cochlear structures in the course of cochlear implantation...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/28630763/malignant-tumours-of-the-foot-and-ankle
#5
E Mascard, N Gaspar, L Brugières, C Glorion, S Pannier, A Gomez-Brouchet
Most of tumours of the foot are tumour-like (synovial cyst, foreign body reactions and epidermal inclusion cyst) or benign conditions (tenosynovial giant cells tumours, planta fibromatosis). Malignant tumours of the soft-tissue and skeleton are very rare in the foot and their diagnosis is often delayed with referral to specialised teams after initial inappropriate procedures or unplanned excisions. The adverse effect of these misdiagnosed tumours is the increasing rate of amputation or local recurrences in the involved patients...
May 2017: EFORT open reviews
https://www.readbyqxmd.com/read/28628917/anatomical-characteristics-of-facial-nerve-and-cochlea-interaction
#6
Nadine Schart-Morén, Sune Larsson, Helge Rask-Andersen, Hao Li
OBJECTIVE: The aim was to study the relationship between the labyrinthine portion (LP) of the facial canal and the cochlea in human inner ear molds and temporal bones using micro-CT and 3D rendering. A reduced cochlea-facial distance may spread electric currents from the cochlear implant to the LP and cause facial nerve stimulation. Influencing factors may be the topographic anatomy and otic capsule properties. METHODS: An archival collection of human temporal bones underwent micro-CT and 3D reconstruction...
June 20, 2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/28623521/exploring-for-the-optimal-structural-design-for-the-3d-printing-technology-for-cranial-reconstruction-a-biomechanical-and-histological-study-comparison-of-solid-vs-porous-structure
#7
Jun Young Lim, Namhyun Kim, Jong-Chul Park, Sun K Yoo, Dong Ah Shin, Kyu-Won Shim
PURPOSE: Cranioplasty for recovering skull defects carries the risk for a number of complications. Various materials are used, including autologous bone graft, metallic materials, and non-metallic materials, each of which has advantages and disadvantages. If the use of autologous bone is not feasible, those artificial materials also have constraints in the case of complex anatomy and/or irregular defects. MATERIAL AND METHODS: This study used metal 3D-printing technology to overcome these existing drawbacks and analyze the clinical and mechanical performance requirements...
June 16, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28622924/functional-associations-between-support-use-and-forelimb-shape-in-strepsirrhines-and-their-relevance-to-inferring-locomotor-behavior-in-early-primates
#8
Anne-Claire Fabre, Judit Marigó, Michael C Granatosky, Daniel Schmitt
The evolution of primates is intimately linked to their initial invasion of an arboreal environment. However, moving and foraging in this milieu creates significant mechanical challenges related to the presence of substrates differing in their size and orientation. It is widely assumed that primates are behaviorally and anatomically adapted to movement on specific substrates, but few explicit tests of this relationship in an evolutionary context have been conducted. Without direct tests of form-function relationships in living primates it is impossible to reliably infer behavior in fossil taxa...
July 2017: Journal of Human Evolution
https://www.readbyqxmd.com/read/28618337/biomechanical-study-of-different-fixation-techniques-for-the-treatment-of-sacroiliac-joint-injuries-using-finite-element-analyses-and-biomechanical-tests
#9
Chian-Her Lee, Ching-Chi Hsu, Po-Yuang Huang
The pelvis is one of the most stressed areas of the human musculoskeletal system due to the transfer of truncal loads to the lower extremities. Sacroiliac joint injury may lead to abnormal joint mechanics and an unstable pelvis. Various fixation techniques have been evaluated and discussed. However, it may be difficult to investigate each technique due to variations in bone quality, bone anatomy, fracture pattern, and fixation location. Additionally, the finite element method is one useful technology that avoids these variations...
June 7, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28616681/frequency-and-anatomical-features-of-the-mandibular-lingual-foramina-systematic-review-and-meta-analysis
#10
REVIEW
Sara Bernardi, Serena Bianchi, Maria Adelaide Continenza, Guido Macchiarelli
Lingual mandibular foramina are peculiar anatomical variations often present on the bone surface of the inferior jaw. These structures host vascular and nervous anastomosis deriving from the branches of the submental artery, lingual artery, and the mylohyoid nerve. Reports pointed out intra-operative massive bleeding accidents during implant interventions occurred in this area. The aim of this systematic review and meta-analysis was to summarize quantitatively the features of the lingual foramina on the midline of the inferior jaw...
June 14, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/28614638/development-and-validation-of-a-3d-printed-model-of-the-ostiomeatal-complex-and-frontal-sinus-for-endoscopic-sinus-surgery-training
#11
Abdulaziz S Alrasheed, Lily H P Nguyen, Luc Mongeau, W Robert J Funnell, Marc A Tewfik
BACKGROUND: Endoscopic sinus surgery poses unique training challenges due to complex and variable anatomy, and the risk of major complications. We sought to create and provide validity evidence for a novel 3D-printed simulator of the nose and paranasal sinuses. METHODS: Sinonasal computed tomography (CT) images of a patient were imported into 3D visualization software. Segmentation of bony and soft tissue structures was then performed. The model was printed using simulated bone and soft tissue materials...
June 14, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28614531/alternative-option-for-osteogenesis-imperfecta-and-trigeminal-neuralgia
#12
Leonardo Gilmone Ruschel, Guilherme José Agnoletto, Sonival Cândido Hunhevicz, Daniel Benzecry de Almeida, Walter Oleschko Arruda
Osteogenesis imperfecta (OI) is a bone disorder that can lead to skull base deformities such as basilar invagination, which can cause compression of cranial nerves, including the trigeminal nerve. Trigeminal neuralgia in such cases remains a challenge, given distorted anatomy and deformities. We present an alternative option, consisting in cannulation of the foramen ovale and classical percutaneous treatment. Percutaneous balloon microcompression was performed in a 28 year-old woman with OI and severe trigeminal neuralgia using computed tomography (CT) and radiographic-guided cannulation of the Gasserian ganglion without neuronavigation or stereotactic devices...
April 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28603573/extra-articular-tenosynovial-chondromatosis-of-the-finger-a-case-series-study-of-three-cases-one-including-excessive-osseous-invasion
#13
Akio Sakamoto, Takahiko Naka, Eisuke Shiba, Masanori Hisaoka, Shuichi Matsuda
BACKGROUND: Synovial chondromatosis is characterized by cartilaginous metaplasia in synovial tissues. Extra-articular tenosynovial chondromatosis is considered to be an anatomical counterpart of articular synovial chondromatosis. Extra-articular tenosynovial chondromatosis occurs preferentially in the hand, although its frequency is low. RESULTS: We report three cases of extra-articular tenosynovial chondromatosis. A 65-year-old female presented with a history of symptoms over 40 years related to the dorsum of her index finger (Case 1), A 46-year-old female presented with a 6-month history of symptoms at the volar surface of her middle finger (Case 2), and a 66-year-old male presented with a 3-month history of symptoms in a dorsal ring finger...
2017: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/28597129/transcanal-surgery-for-vestibular-schwannomas-a-pictorial-review-of-radiological-findings-surgical-anatomy-and-comparison-to-the-traditional-translabyrinthine-approach
#14
Matteo Alicandri-Ciufelli, Gaia Federici, Lukas Anschuetz, Giacomo Pavesi, Alessandra Todeschini, Livio Presutti, Daniele Marchioni
The most popular approaches for vestibular schwannoma (VS) removal are retrosigmoid, middle cranial fossa and translabyrinthine (TL). All require a certain degree of invasivity, bone removal, or brain manipulation. Recently, the authors described the transcanal transpromontorial approaches (TTA), which allow the inner ear to be accessed directly through the external auditory canal (EAC), either with a microscopic (Expanded TTA, or ExpTTA) or even an exclusive endoscopic technique (Endoscopic TTA, or EndoTTA)...
June 9, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28593553/prenatal-diagnosis-of-spina-bifida-from-intracranial-translucency-to-intrauterine-surgery
#15
Waldo Sepulveda, Amy E Wong, Francisco Sepulveda, Juan L Alcalde, Juan C Devoto, Felipe Otayza
Accurate and timely prenatal diagnosis of spina bifida (SB) is a major goal of modern antenatal care. Prenatal screening for open SB should be first performed at the time of routine first-trimester ultrasound by examining the posterior fossa for obliteration or non-visualization of the fourth ventricle ("intracranial translucency") and cisterna magna. The second step of screening is the second-trimester anatomy scan, at which time the features of the Chiari type II malformation should be looked for, including ventriculomegaly, scalloping of the frontal bones ("lemon" sign), and backward and caudal displacement of the cerebellar vermis with obliteration of the cisterna magna ("banana" sign)...
June 7, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28585295/bioinspired-collagen-scaffolds-in-cranial-bone-regeneration-from-bedside-to-bench
#16
REVIEW
Justine C Lee, Elizabeth J Volpicelli
Calvarial defects are common reconstructive dilemmas secondary to a variety of etiologies including traumatic brain injury, cerebrovascular disease, oncologic resection, and congenital anomalies. Reconstruction of the calvarium is generally undertaken for the purposes of cerebral protection, contour restoration for psychosocial well-being, and normalization of neurological dysfunction frequently found in patients with massive cranial defects. Current methods for reconstruction using autologous grafts, allogeneic grafts, or alloplastic materials have significant drawbacks that are unique to each material...
June 6, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28583671/biomechanical-behaviour-of-craniofacial-sutures-during-distraction-an-evaluation-all-over-the-entire-craniofacial-skeleton
#17
Fabio Savoldi, James K H Tsoi, Corrado Paganelli, Jukka P Matinlinna
OBJECTIVE: Sutures are fibrous joints connecting the bones of the head. Despite the fundamental role played by sutures in dentofacial orthopaedics, their biomechanical properties are not completely understood. This study evaluated anatomy, biomechanics, and acoustic emission (AE) during distraction of the sutural ligament (SL). METHODS: Seventy-two suture samples were removed from a twelve-months-old swine (Sus scrofa) head. Each volume was acquired using micro-computed tomography (μCT), and the linear interdigitation index was calculated on both planes (LIICOR and LIISAG)...
June 2, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28580200/treatment-outcomes-of-rare-retromolar-trigone-squamous-cell-carcinoma-using-combined-modalities
#18
Muhammad Faisal, Taskheer Abbas, Usman Khaleeq, Mohammad Adeel, Abdul Wahid Anwer, Raza Hussain, Arif Jamshed
BACKGROUND: Retromolar trigone squamous cell carcinoma is relatively uncommon and due to its complex anatomy has always remained a challenge in terms of loco-regional control and survival. Surgery, radiotherapy, and chemotherapy as combined modalities have been used but high recurrence rates result in poor outcome. METHODS: We have retrospectively evaluated records of 62 patients treated in Head and Neck Oncology unit of Shaukat Khanum Memorial Cancer Hospital and Research Centre (SKMCH and RC), Lahore, Pakistan from 2004 to 2014 who were included based on the criteria of histopathological proven squamous cell carcinoma of retromolar trigone (RMT) treated with radical intent...
May 1, 2017: Curēus
https://www.readbyqxmd.com/read/28578109/reconstruction-of-the-thoracic-spine-using-a-personalized-3d-printed-vertebral-body-in-an-adolescent-with-a-t9-primary-bone-tumour-case-report
#19
Wen Jie Choy, Ralph J Mobbs, Ben Wilcox, Steven Phan, Kevin Phan, Chester E Sutterlin
BACKGROUND: Neurosurgery and spine surgery has the potential to benefit from the use of three-dimensional printing (3DP) technology due to complex anatomical considerations and the delicate nature of surrounding structures. We report a procedure which utilises a 3D printed titanium T9 vertebral body implant post T9 vertebrectomy for a primary bone tumour. CASE DESCRIPTION: A 14-year-old female presented with progressive kyphoscoliosis, and a pathological fracture of the T9 vertebra with sagittal and coronal deformity due to a destructive primary bone tumour...
May 31, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28576712/preserving-the-facial-nerve-during-the-orbitozygomatic-craniotomy-surgical-anatomy-assessment-and-stepwise-illustration
#20
Ali Tayebi Meybodi, Michael T Lawton, Sonia Yousef, Jj González Sánchez, Arnau Benet
OBJECTIVE: Surgical safety and efficiency during an OZ osteotomy rely on thorough knowledge of the surgical anatomy of the facial nerve. Although the anatomy of the facial nerve and its relation to the pterional craniotomy are described, a thorough assessment of facial nerve preservation techniques during the OZ approach and its variations is lacking. We assessed the surgical anatomy of the facial nerve related to the OZ and provided a thorough stepwise description on how to preserve it...
May 30, 2017: World Neurosurgery
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