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https://www.readbyqxmd.com/read/29201347/the-creation-and-evaluation-of-a-model-to-simulate-the-probability-of-conception-in-seasonal-calving-pasture-based-dairy-heifers
#1
Caroline Fenlon, Luke O'Grady, Stephen Butler, Michael L Doherty, John Dunnion
Background: Herd fertility in pasture-based dairy farms is a key driver of farm economics. Models for predicting nulliparous reproductive outcomes are rare, but age, genetics, weight, and BCS have been identified as factors influencing heifer conception. The aim of this study was to create a simulation model of heifer conception to service with thorough evaluation. Methods: Artificial Insemination service records from two research herds and ten commercial herds were provided to build and evaluate the models...
2017: Irish Veterinary Journal
https://www.readbyqxmd.com/read/29182662/threats-from-urban-expansion-agricultural-transformation-and-forest-loss-on-global-conservation-priority-areas
#2
Victoria Veach, Atte Moilanen, Enrico Di Minin
Including threats in spatial conservation prioritization helps identify areas for conservation actions where biodiversity is at imminent risk of extinction. At the global level, an important limitation when identifying spatial priorities for conservation actions is the lack of information on the spatial distribution of threats. Here, we identify spatial conservation priorities under three prominent threats to biodiversity (residential and commercial development, agricultural expansion, and forest loss), which are primary drivers of habitat loss and threaten the persistence of the highest number of species in the International Union for the Conservation of Nature (IUCN) Red List, and for which spatial data is available...
2017: PloS One
https://www.readbyqxmd.com/read/29181493/neflamapimod-clinical-phase-2b-ready-oral-small-molecule-inhibitor-of-p38%C3%AE-to-reverse-synaptic-dysfunction-in-early-alzheimer-s-disease
#3
J Alam, K Blackburn, D Patrick
Neflamapimod (previously code named VX-745) is a clinical phase 2b-ready highly specific inhibitor of the intra-cellular enzyme p38 mitogen activated protein kinase alpha ("p38α") that is being developed as a disease-modifying drug for Alzheimer's disease (AD) that acts via targeting synaptic dysfunction. Neflamapimod was discovered through a proprietary structure-based drug discovery platform at Vertex Pharmaceuticals, and developed previously by Vertex through to phase 2a in rheumatoid arthritis. EIP Pharma licensed the compound in 2014 for development and commercialization as a treatment of central nervous system (CNS) disorders...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29174330/association-between-commercial-vehicle-driver-at-fault-crashes-involving-sleepiness-fatigue-and-proximity-to-rest-areas-and-truck-stops
#4
Terry L Bunn, Svetla Slavova, Peter J Rock
INTRODUCTION: There is ongoing concern at the national level about the availability of adequate commercial vehicle rest areas and truck stops for commercial vehicle drivers to rest or to wait for a delivery window. METHODS: A retrospective case-control study was conducted to determine the association between the occurrence of sleepiness/fatigue-related (cases) vs. all other human factor-related commercial vehicle driver at-fault crashes (controls) and proximity to rest areas, weigh stations with rest havens, and truck stops...
November 22, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29135266/fast-metabolite-identification-in-nuclear-magnetic-resonance-metabolomic-studies-statistical-peak-sorting-and-peak-overlap-detection-for-more-reliable-database-queries
#5
Pablo A Hoijemberg, Istvan Pelczer
A lot of time is spent by researchers in the identification of metabolites in NMR-based metabolomic studies. The usual metabolite identification starts employing public or commercial databases to match chemical shifts thought to belong to a given compound. Statistical total correlation spectroscopy (STOCSY), in use for more than a decade, speeds the process by finding statistical correlations among peaks, being able to create a better peak list as input for the database query. However, the (normally not automated) analysis becomes challenging due to the intrinsic issue of peak overlap, where correlations of more than one compound appear in the STOCSY trace...
November 14, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/29122353/enteric-methane-emissions-and-their-response-to-agro-ecological-and-livestock-production-systems-dynamics-in-zimbabwe
#6
Walter Svinurai, Farai Mapanda, Dingane Sithole, Elisha N Moyo, Kudzai Ndidzano, Alois Tsiga, Washington Zhakata
Without disregarding its role as one of the key sources of sustainable livelihoods in Zimbabwe and other developing countries, livestock production contributes significantly to greenhouse gas (GHG) emissions through enteric fermentation. For the livestock sector to complement global efforts to mitigate climate change, accurate estimations of GHG emissions are required. Methane emissions from enteric fermentation in Zimbabwe were quantified over 35years under four production systems and five agro-ecological regions...
November 6, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29096961/cooking-and-co-ingested-polyphenols-reduce-in-vitro-methylmercury-bioaccessibility-from-fish-and-may-alter-exposure-in-humans
#7
Catherine Girard, Tania Charette, Maxime Leclerc, B Jesse Shapiro, Marc Amyot
Fish consumption is a major pathway for mercury exposure in humans. Current guidelines and risk assessments assume that 100% of methylmercury (MeHg) in fish is absorbed by the human body after ingestion. However, a growing body of literature suggests that this absorption rate may be overestimated. We used an in vitro digestion method to measure MeHg bioaccessibility in commercially-purchased fish, and investigated the effects of dietary practices on MeHg bioaccessibility. Cooking had the greatest effect, decreasing bioaccessibility on average to 12...
October 30, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29092783/determinants-of-policy-decisions-for-non-commercial-drivers-with-osa-an-integrative-review
#8
REVIEW
Dorrie Rizzo, Eva Libman, Laura Creti, Marc Baltzan, Sally Bailes, Catherine Fichten, Gilles Lavigne
Excessive daytime sleepiness and reduced cognitive functioning secondary to obstructive sleep apnea (OSA) have been identified as an important health-related risk in commercial transportation with, possibly, an increased chance of road accidents. This has resulted in a variety of policies and restrictions imposed on commercial drivers. Here we review current knowledge to assess whether available data are sufficient to guide policy decisions concerning restrictions for non-commercial drivers. The review shows that there is a lack of uniformity among different consensus conferences and guidelines as to how to deal with drivers with OSA...
February 20, 2017: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/29074223/is-the-epworth-sleepiness-scale-a-useful-tool-for-screening-excessive-daytime-sleepiness-in-commercial-drivers
#9
Simone Baiardi, Chiara La Morgia, Lucia Sciamanna, Alberto Gerosa, Fabio Cirignotta, Susanna Mondini
The significant social and economic impact of excessive daytime sleepiness makes sleep evaluation a primary medical need in commercial drivers. However, the best screening tool is still matter of debate. In our cohort of 221 commercial drivers, only ten (4.5%) had Epworth Sleepiness Scale scores indicative of excessive daytime sleepiness. These findings and the lack of concordance in estimating excessive daytime sleepiness among commercial drivers in previous studies using the same psychometric measure indicate that the Epworth Sleepiness Scale is not a reliable tool...
October 23, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29064184/cystic-fibrosis-clinical-characteristics-associated-with-dornase-alfa-treatment-regimen-change
#10
Donald R VanDevanter, Marcia L Craib, David J Pasta, Stefanie J Millar, Wayne J Morgan, Michael W Konstan
BACKGROUND: When the chronic respiratory therapy dornase alfa was made commercially available for cystic fibrosis (CF) more than 20 years ago, two regimens were approved: 2.5 mg inhaled once daily (QD) or twice daily (BID). In the intervening years, there has been little guidance as to when to use each regimen. We have studied clinical practice patterns captured in the Epidemiologic Study of CF (ESCF) during the decade following dornase alfa approval (1994-2005) to better understand clinical characteristics associated with QD versus BID dornase alfa use...
October 24, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29057396/effects-of-actigraphically-acquired-sleep-quality-ondriving-outcomes-in-obstructive-sleep-apnea-patientsand-control-drivers-a-naturalistic-study
#11
Nazan Aksan, Robert Marini, Jon Tippin, Jeffrey Dawson, Matthew Rizzo
We examined the effects of sleep quality on next day driving outcomes in a 3.5-month naturalistic driving study of 67 OSA and 47 matched control drivers. Sleep quality measures included total sleep time and sleep fragmentation from actigraphy. The driving outcomes included average speed, lateral control, longitudinal control, distraction, attention to driving- and non-driving related tasks. Sleep quality affected next day's driving performance differently for OSA and control drivers. Better sleep quality was associated with better lateral and longitudinal control during highway driving for control drivers...
2017: Proceedings of the ... International Driving Symposium on Human Factors in Driver Assessment, Training, and Vehicle Design
https://www.readbyqxmd.com/read/29051311/quantitative-analysis-of-antibiotic-usage-in-british-sheep-flocks
#12
Peers Davies, John G Remnant, Martin J Green, Emily Gascoigne, Nick Gibbon, Robert Hyde, Jack R Porteous, Kiera Schubert, Fiona Lovatt, Alexander Corbishley
The aim of this study was to examine the variation in antibiotic usage between 207 commercial sheep flocks using their veterinary practice prescribing records. Mean and median prescribed mass per population corrected unit (mg/PCU) was 11.38 and 5.95, respectively and closely correlated with animal defined daily dose (ADDD) 1.47 (mean), 0.74 (median) (R(2)=0.84, P<0.001). This is low in comparison with the suggested target (an average across all the UK livestock sectors) of 50 mg/PCU. In total, 80 per cent of all antibiotic usage occurred in the 39 per cent of flocks where per animal usage was greater than 9...
October 19, 2017: Veterinary Record
https://www.readbyqxmd.com/read/29034057/design-and-fabrication-of-a-low-cost-three-dimensional-bioprinter
#13
Colton McElheny, Daniel Hayes, Ram Devireddy
Three-dimensional (3D) bioprinting offers innovative research vectors for tissue engineering. However, commercially available bioprinting platforms can be cost prohibitive to small research facilities, especially in an academic setting. The goal is to design and fabricate a low-cost printing platform able to deliver cell-laden fluids with spatial accuracy along the X, Y, and Z axes of 0.1 mm. The bioprinter consists of three subassemblies: a base unit, a gantry, and a shuttle component. The platform utilizes four stepper motors to position along three axes and a fifth stepper motor actuating a pump...
December 2017: Journal of Medical Devices
https://www.readbyqxmd.com/read/29025245/hepatic-chemerin-mrna-in-morbidly-obese-patients-with-nonalcoholic-fatty-liver-disease
#14
Maciej Kajor, Michał Kukla, Marek Waluga, Łukasz Liszka, Michał Dyaczyński, Grzegorz Kowalski, Dominika Żądło, Agnieszka Berdowska, Mateusz Chapuła, Anna Kostrząb-Zdebel, Rafał J Bułdak, Tomasz Sawczyn, Marek Hartleb
The aim of this study was to investigate hepatic chemerin mRNA, serum chemerin concentration, and immunohistochemical staining for chemerin and and chemokine receptor-like 1 (CMKLR1) in hepatic tissue in 56 morbidly obese women with nonalcoholic fatty liver disease (NAFLD) and to search for a relationship with metabolic and histopathological features. Chemerin mRNA was assessed by quantitative real-time PCR, chemerin, and CMKLR1 immunohistochemical expression with specific antibodies, while serum chemerin concentration was assessed with commercially available enzyme-linked immunosorbent assays...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29020279/cost-drivers-of-a-hospital-acquired-bacterial-pneumonia-and-ventilator-associated-bacterial-pneumonia-habp-vabp-phase-three-clinical-trial
#15
Stella Stergiopoulos, Sara B Calvert, Carrie A Brown, Josephine Awatin, Pamela Tenaerts, Thomas L Holland, Joseph A DiMasi, Kenneth A Getz
Background: Studies indicate that the prevalence of multi-drug resistant infections, including hospital acquired and ventilator associated bacterial pneumonia (HABP/VABP), has been rising. There are many challenges associated with these disease conditions and the ability to develop new treatments. Additionally, HABP/VABP clinical trials are very costly to conduct given their complex protocol designs and the difficulty in recruiting and retaining patients. Methodology: With input from clinicians, representatives from industry, and the Food and Drug Administriation (FDA), we conducted a study to (1) evaluate the drivers of HABP/VABP phase 3 direct and indirect clinical trial costs, (2) to identify opportunities to lower these costs, and (3) to compare (1) and (2) to endocrine and oncology clinical trials...
August 17, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28978270/low-back-pain-and-its-association-with-whole-body-vibration-and-manual-material-handling-among-commercial-drivers-in-sabah
#16
Khamisah Awang Lukman, Mohammad Saffree Jeffree, Krishna Gopal Rampal
A cross-sectional study was undertaken to determine the prevalence of low back pain (LBP) and its association with whole body vibration (WBV) and manual material handling (MMH). We studied 110 commercial vehicle drivers. A self-administered questionnaire and the human vibration V1-400Pro (QUEST) monitor were used. The prevalence of LBP was 66.4%. The percentage of drivers who had frequent manual handling of heavy loads was 45.5% and those who handled heavy loads in awkward postures accounted for 86.4%. The daily vibration, A(8) averaged at z axis was 0...
October 5, 2017: International Journal of Occupational Safety and Ergonomics: JOSE
https://www.readbyqxmd.com/read/28977634/using-local-authority-entrance-charges-to-tackle-inequalities-in-physical-activity-a-qualitative-study-of-leisure-and-public-health-perspectives
#17
E Halliday, B Barr, J Higgerson, V Holt, A Ortiz-Nunez, F Ward
Background: Reducing or eliminating entrance charges for the public use of leisure facilities is one potential tool that local authorities (LA) have to reduce inequalities in physical activity (PA). Facility charges are likely to be a greater barrier to access for those who have lower incomes. Methods: Semi-structured 1-to-1 and group interviews were conducted with 33 leisure and public health professionals in seven LAs in north-west England. We investigated how approaches to pricing varied in these settings and rationales influencing decision making...
September 11, 2017: Journal of Public Health
https://www.readbyqxmd.com/read/28975018/comprehensive-genomic-profiling-of-a-rare-thyroid-follicular-dendritic-cell-sarcoma
#18
Jaime I Davila, Jason S Starr, Steven Attia, Chen Wang, Ryan A Knudson, Brian M Necela, Vivekananda Sarangi, Zhifu Sun, Yingxue Ren, John D Casler, David M Menke, Gavin R Oliver, Richard W Joseph, John A Copland, Alexander S Parker, Jean-Pierre A Kocher, E Aubrey Thompson, Robert C Smallridge, Yan W Asmann
We previously reported an extremely rare case of follicular dendritic cell sarcoma (FDCS) presented as a thyroid mass. Given the rarity of this disease, there are no personalized and molecularly targeted treatment options due to the lack of knowledge in the genomic makeup of the tumor. A 44-year-old white woman was diagnosed with an extranodal FDCS in thyroid. The patient underwent a total thyroidectomy, central compartment dissection, parathyroid re-implantation, and adjuvant radiation therapy. Tumor DNA sequencing of 236 genes by FoundationOne panel found truncating mutations in PTEN and missense mutations in RET and TP53...
July 3, 2017: Rare Tumors
https://www.readbyqxmd.com/read/28956991/persistence-of-trichomonas-gallinae-in-birdseed
#19
Scott McBurney, Whitney K Kelly-Clark, María J Forzán, Raphaël Vanderstichel, Kevin Teather, Spencer J Greenwood
Trichomonas gallinae has emerged worldwide as a cause of mortality in songbirds (passerines). The congregation of numerous birds, including the reservoir hosts, pigeons and doves (columbids), at backyard feeding and watering sources has been suggested as a potential driver for the outbreaks. Evidence supporting a role for water in transmission has been established, but the role of birdseed in the transmission of trichomoniasis remained to be investigated. We assessed the survival of T. gallinae in three commercial birdseeds (mixed seed, black-oil sunflower seed, and niger seed) routinely used to attract passerine birds to local properties...
September 2017: Avian Diseases
https://www.readbyqxmd.com/read/28949463/providing-value-to-new-health-technology-the-early-contribution-of-entrepreneurs-investors-and-regulatory-agencies
#20
Pascale Lehoux, Fiona A Miller, Geneviève Daudelin, Jean-Louis Denis
BACKGROUND: New technologies constitute an important cost-driver in healthcare, but the dynamics that lead to their emergence remains poorly understood from a health policy standpoint. The goal of this paper is to clarify how entrepreneurs, investors, and regulatory agencies influence the value of emerging health technologies. METHODS: Our 5-year qualitative research program examined the processes through which new health technologies were envisioned, financed, developed and commercialized by entrepreneurial clinical teams operating in Quebec's (Canada) publicly funded healthcare system...
January 25, 2017: International Journal of Health Policy and Management
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