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https://www.readbyqxmd.com/read/29034057/design-and-fabrication-of-a-low-cost-three-dimensional-bioprinter
#1
Colton McElheny, Daniel Hayes, Ram Devireddy
Three-dimensional (3D) bioprinting offers innovative research vectors for tissue engineering. However, commercially available bioprinting platforms can be cost prohibitive to small research facilities, especially in an academic setting. The goal is to design and fabricate a low-cost printing platform able to deliver cell-laden fluids with spatial accuracy along the X, Y, and Z axes of 0.1 mm. The bioprinter consists of three subassemblies: a base unit, a gantry, and a shuttle component. The platform utilizes four stepper motors to position along three axes and a fifth stepper motor actuating a pump...
December 2017: Journal of Medical Devices
https://www.readbyqxmd.com/read/29025245/hepatic-chemerin-mrna-in-morbidly-obese-patients-with-nonalcoholic-fatty-liver-disease
#2
Maciej Kajor, Michał Kukla, Marek Waluga, Łukasz Liszka, Michał Dyaczyński, Grzegorz Kowalski, Dominika Żądło, Agnieszka Berdowska, Mateusz Chapuła, Anna Kostrząb-Zdebel, Rafał J Bułdak, Tomasz Sawczyn, Marek Hartleb
The aim of this study was to investigate hepatic chemerin mRNA, serum chemerin concentration, and immunohistochemical staining for chemerin and and chemokine receptor-like 1 (CMKLR1) in hepatic tissue in 56 morbidly obese women with nonalcoholic fatty liver disease (NAFLD) and to search for a relationship with metabolic and histopathological features. Chemerin mRNA was assessed by quantitative real-time PCR, chemerin, and CMKLR1 immunohistochemical expression with specific antibodies, while serum chemerin concentration was assessed with commercially available enzyme-linked immunosorbent assays...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29020279/cost-drivers-of-a-hospital-acquired-bacterial-pneumonia-and-ventilator-associated-bacterial-pneumonia-habp-vabp-phase-three-clinical-trial
#3
Stella Stergiopoulos, Sara B Calvert, Carrie A Brown, Josephine Awatin, Pamela Tenaerts, Thomas L Holland, Joseph A DiMasi, Kenneth A Getz
Background: Studies indicate that the prevalence of multi-drug resistant infections, including hospital acquired and ventilator associated bacterial pneumonia (HABP/VABP), has been rising. There are many challenges associated with these disease conditions and the ability to develop new treatments. Additionally, HABP/VABP clinical trials are very costly to conduct given their complex protocol designs and the difficulty in recruiting and retaining patients. Methodology: With input from clinicians, representatives from industry, and the Food and Drug Administriation (FDA), we conducted a study to (1) evaluate the drivers of HABP/VABP phase 3 direct and indirect clinical trial costs, (2) to identify opportunities to lower these costs, and (3) to compare (1) and (2) to endocrine and oncology clinical trials...
August 17, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28978270/low-back-pain-and-its-association-with-whole-body-vibration-and-manual-material-handling-among-commercial-drivers-in-sabah
#4
Khamisah Awang Lukman, Mohammad Saffree Jeffree, Krishna Gopal Rampal
A cross-sectional study was undertaken to determine the prevalence of low back pain (LBP) and its association with whole body vibration (WBV) and manual material handling (MMH). We studied 110 commercial vehicle drivers. A self-administered questionnaire and the human vibration V1-400Pro (QUEST) monitor were used. The prevalence of LBP was 66.4%. The percentage of drivers who had frequent manual handling of heavy loads was 45.5% and those who handled heavy loads in awkward postures accounted for 86.4%. The daily vibration, A(8) averaged at z axis was 0...
October 5, 2017: International Journal of Occupational Safety and Ergonomics: JOSE
https://www.readbyqxmd.com/read/28977634/using-local-authority-entrance-charges-to-tackle-inequalities-in-physical-activity-a-qualitative-study-of-leisure-and-public-health-perspectives
#5
E Halliday, B Barr, J Higgerson, V Holt, A Ortiz-Nunez, F Ward
Background: Reducing or eliminating entrance charges for the public use of leisure facilities is one potential tool that local authorities (LA) have to reduce inequalities in physical activity (PA). Facility charges are likely to be a greater barrier to access for those who have lower incomes. Methods: Semi-structured 1-to-1 and group interviews were conducted with 33 leisure and public health professionals in seven LAs in north-west England. We investigated how approaches to pricing varied in these settings and rationales influencing decision making...
September 11, 2017: Journal of Public Health
https://www.readbyqxmd.com/read/28975018/comprehensive-genomic-profiling-of-a-rare-thyroid-follicular-dendritic-cell-sarcoma
#6
Jaime I Davila, Jason S Starr, Steven Attia, Chen Wang, Ryan A Knudson, Brian M Necela, Vivekananda Sarangi, Zhifu Sun, Yingxue Ren, John D Casler, David M Menke, Gavin R Oliver, Richard W Joseph, John A Copland, Alexander S Parker, Jean-Pierre A Kocher, E Aubrey Thompson, Robert C Smallridge, Yan W Asmann
We previously reported an extremely rare case of follicular dendritic cell sarcoma (FDCS) presented as a thyroid mass. Given the rarity of this disease, there are no personalized and molecularly targeted treatment options due to the lack of knowledge in the genomic makeup of the tumor. A 44-year-old white woman was diagnosed with an extranodal FDCS in thyroid. The patient underwent a total thyroidectomy, central compartment dissection, parathyroid re-implantation, and adjuvant radiation therapy. Tumor DNA sequencing of 236 genes by FoundationOne panel found truncating mutations in PTEN and missense mutations in RET and TP53...
July 3, 2017: Rare Tumors
https://www.readbyqxmd.com/read/28956991/persistence-of-trichomonas-gallinae-in-birdseed
#7
Scott McBurney, Whitney K Kelly-Clark, María J Forzán, Raphaël Vanderstichel, Kevin Teather, Spencer J Greenwood
Trichomonas gallinae has emerged worldwide as a cause of mortality in songbirds (passerines). The congregation of numerous birds, including the reservoir hosts, pigeons and doves (columbids), at backyard feeding and watering sources has been suggested as a potential driver for the outbreaks. Evidence supporting a role for water in transmission has been established, but the role of birdseed in the transmission of trichomoniasis remained to be investigated. We assessed the survival of T. gallinae in three commercial birdseeds (mixed seed, black-oil sunflower seed, and niger seed) routinely used to attract passerine birds to local properties...
September 2017: Avian Diseases
https://www.readbyqxmd.com/read/28949463/providing-value-to-new-health-technology-the-early-contribution-of-entrepreneurs-investors-and-regulatory-agencies
#8
Pascale Lehoux, Fiona A Miller, Geneviève Daudelin, Jean-Louis Denis
BACKGROUND: New technologies constitute an important cost-driver in healthcare, but the dynamics that lead to their emergence remains poorly understood from a health policy standpoint. The goal of this paper is to clarify how entrepreneurs, investors, and regulatory agencies influence the value of emerging health technologies. METHODS: Our 5-year qualitative research program examined the processes through which new health technologies were envisioned, financed, developed and commercialized by entrepreneurial clinical teams operating in Quebec's (Canada) publicly funded healthcare system...
January 25, 2017: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/28902990/high-purity-semiconducting-single-walled-carbon-nanotubes-a-key-enabling-material-in-emerging-electronics
#9
Jacques Lefebvre, Jianfu Ding, Zhao Li, Paul Finnie, Gregory Lopinski, Patrick R L Malenfant
Semiconducting single-walled carbon nanotubes (sc-SWCNTs) are emerging as a promising material for high-performance, high-density devices as well as low-cost, large-area macroelectronics produced via additive manufacturing methods such as roll-to-roll printing. Proof-of-concept demonstrations have indicated the potential of sc-SWCNTs for digital electronics, radiofrequency circuits, radiation hard memory, improved sensors, and flexible, stretchable, conformable electronics. Advances toward commercial applications bring numerous opportunities in SWCNT materials development and characterization as well as fabrication processes and printing technologies...
October 17, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28882261/factors-contributing-to-commercial-vehicle-rear-end-conflicts-in-china-a-study-using-on-board-event-data-recorders
#10
Giulio Bianchi Piccinini, Johan Engström, Jonas Bärgman, Xuesong Wang
INTRODUCTION: In the last 30years, China has undergone a dramatic increase in vehicle ownership and a resulting escalation in the number of road crashes. Although crash figures are decreasing today, they remain high; it is therefore important to investigate crash causation mechanisms to further improve road safety in China. METHOD: To shed more light on the topic, naturalistic driving data was collected in Shanghai as part of the evaluation of a behavior-based safety service...
September 2017: Journal of Safety Research
https://www.readbyqxmd.com/read/28869150/the-association-between-hematological-parameters-and-metabolic-syndrome-in-iranian-men-a-single-center-large-scale-study
#11
Jamal Ahmadzadeh, Behnam Mansorian, Mohammad Mirza-Aghazadeh Attari, Ira Mohebbi, Raha Naz-Avar, Karaim Moghadam, Seyyed Adel Khoshbou Ghareh-Bagh
AIMS: Some studies have demonstrated that metabolic syndrome is associated with hematological parameters. The present study explores the relationship between hematological parameters and numbers of metabolic syndrome conditions in Iranian men. METHODS: This cross-sectional study included 11,114 participants who were professional drivers of commercial motor vehicles, and were enrolled in the Iranian Health Surveys between 2014 and 2016. Diagnosis of metabolic syndrome was made according to International Diabetes Federation criteria...
August 23, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28866551/bastet-shareable-and-reproducible-analysis-and-visualization-of-mass-spectrometry-imaging-data-via-openmsi
#12
Oliver Rubel, Benjamin P Bowen
Mass spectrometry imaging (MSI) is a transformative imaging method that supports the untargeted, quantitative measurement of the chemical composition and spatial heterogeneity of complex samples with broad applications in life sciences, bioenergy, and health. While MSI data can be routinely collected, its broad application is currently limited by the lack of easily accessible analysis methods that can process data of the size, volume, diversity, and complexity generated by MSI experiments. The development and application of cutting-edge analytical methods is a core driver in MSI research for new scientific discoveries, medical diagnostics, and commercial-innovation...
August 29, 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/28865928/the-use-of-a-driving-simulator-to-determine-how-time-pressures-impact-driver-aggressiveness
#13
Cole D Fitzpatrick, Siby Samuel, Michael A Knodler
Speeding greatly attributes to traffic safety with approximately a third of fatal crashes in the United States being speeding-related. Previous research has identified being late as a primary cause of speeding. In this driving simulator study, a virtual drive was constructed to evaluate how time pressures, or hurried driving, affected driver speed choice and driver behavior. In particular, acceleration profiles, gap acceptance, willingness to pass, and dilemma zone behavior were used, in addition to speed, as measures to evaluate whether being late increased risky and aggressive driving behaviors...
November 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28860410/next-generation-sequencing-for-patients-with-sarcoma-a-single-center-experience
#14
Gregory M Cote, Jie He, Edwin Choy
BACKGROUND: Sarcomas comprise over 50 subtypes of mesenchymal cancers. For the majority of sarcomas, the driver mutations remain unknown. In this article, we describe our experience with a targeted next-generation sequencing (NGS) platform in clinic patients. MATERIALS AND METHODS: We retrospectively analyzed results of NGS using 133 tumor samples from patients diagnosed with a variety of sarcomas that were analyzed with targeted NGS covering over 400 cancer-related genes (405 DNA, 265 RNA) on a commercially available platform...
August 31, 2017: Oncologist
https://www.readbyqxmd.com/read/28851365/primary-care-clinical-practice-guidelines-in-south-africa-qualitative-study-exploring-perspectives-of-national-stakeholders
#15
Tamara Kredo, Amber Abrams, Taryn Young, Quinette Louw, Jimmy Volmink, Karen Daniels
BACKGROUND: Clinical practice guidelines (CPGs) are common tools in policy and clinical practice informing clinical decisions at the bedside, governance of health facilities, health insurer and government spending, and patient choices. South Africa's health sector is transitioning to a national health insurance system, aiming to build on other primary health care initiatives to transform the previously segregated, inequitable services. Within these plans CPGs are an integral tool for delivering standardised and cost effective care...
August 29, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28819996/commercial-golf-glove-effects-on-golf-performance-and-forearm-muscle-activity
#16
Graeme G Sorbie, Paul Darroch, Fergal M Grace, Yaodong Gu, Julien S Baker, Ukadike C Ugbolue
The study aimed to determine whether or not commercial golf gloves influence performance variables and forearm muscle activity during golf play. Fifteen golfers participated in the laboratory based study, each performing 8 golf swings with a Driver and 7-iron whilst wearing a glove and 8 without wearing the glove. Club head speed, ball speed and absolute carry distance performance variables were calculated. Surface electromyography was recorded from the flexor digitorum superficialis and extensor carpi radialis brevis on both forearm muscles...
August 18, 2017: Research in Sports Medicine
https://www.readbyqxmd.com/read/28812453/ergonomic-evaluation-of-a-new-truck-seat-design-a-field-study
#17
Michelle Cardoso, Fred Fulton, Colin McKinnon, Jack P Callaghan, Michel J Johnson, Wayne J Albert
A postural evaluation of commercial licensed truck drivers was conducted to determine the ergonomic benefits of a truck seat prototype in comparison to an Industry standard seat. Twenty commercially licensed truck drivers were recruited to perform a 90-min driving task. Postures were assessed using accelerometers and a backrest and seat pan pressure mapping system. Subjective discomfort measurements were monitored using two questionnaires: ratings of perceived discomfort (RPD) and the automotive seating discomfort questionnaire (ASDQ)...
August 16, 2017: International Journal of Occupational Safety and Ergonomics: JOSE
https://www.readbyqxmd.com/read/28801473/type-2-diabetes-in-the-real-world-the-elusive-nature-of-glycemic-control
#18
Steven V Edelman, William H Polonsky
Despite U.S. Food and Drug Administration (FDA) approval of over 40 new treatment options for type 2 diabetes since 2005, the latest data from the National Health and Nutrition Examination Survey show that the proportion of patients achieving glycated hemoglobin (HbA1c) <7.0% (<53 mmol/mol) remains around 50%, with a negligible decline between the periods 2003-2006 and 2011-2014. The Healthcare Effectiveness Data and Information Set reports even more alarming rates, with only about 40% and 30% of patients achieving HbA1c <7...
August 11, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28766749/sensory-and-analytical-characterization-of-the-cool-melting-perception-of-commercial-spreads
#19
Verónica Galindo-Cuspinera, Joana Valenҁa de Sousa, Marcia Knoop
Butters, margarines and table spreads are water-in-oil emulsions. Melting characteristics of these products are important for flavor release and consumer acceptance. One characteristic that is believed to discriminate butters from margarines is a cooling sensation perceived in-mouth while consuming these products. Here, we investigated different methods to characterize sensorically and analytically the "cool-melting" properties of commercial butter and margarines. Our results show that butter indeed can be distinguished from margarines based on their "cool-melting" properties...
August 2017: Journal of Texture Studies
https://www.readbyqxmd.com/read/28738684/drivers-of-excess-costs-of-opioid-abuse-among-a-commercially-insured-population
#20
Lauren M Scarpati, Noam Y Kirson, Miriam L Zichlin, Zitong B Jia, Howard G Birnbaum, Jaren C Howard
OBJECTIVES: To replicate and extend a recently published analysis of the drivers of excess costs of opioid abuse. STUDY DESIGN: Retrospective data analysis using de-identified claims data from the Truven MarketScan Commercial Claims and Encounter database. METHODS: Medical and prescription drug claims from beneficiaries covered by large self-insured US companies were used to select patients with incident diagnoses of opioid abuse between 2012 and 2015...
May 2017: American Journal of Managed Care
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