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Commercial Drivers

Vincent Ronfard, Alain Vertes, Michael May, Anne Dupraz, Mark van Dyke, Yves Bayon
"Evaluating the Past & Present of Regenerative Medicine (RM)" was the first part of an Industry Symposium dedicated to the subject during the 2015 World TERMIS Congress in Boston. This working session presented a critical review of the current RM landscape in Europe and North America with possible projections for the future. Interestingly, the RM development cycle seems to obey the Gartner hype cycle, now at the enlightenment phase, after past exaggerated expectations and discouragements, as suggested by increasing numbers of clinical trials and recent market approvals of RM solutions in both Europe (Glybera & Holoclar® from Chiesi Pharma and Strimvelis® from GSK) and Japan (Remestemcel-L from Mesoblast® )...
October 20, 2016: Tissue Engineering. Part B, Reviews
Kenneth Amaechi Agu, Vincent Chidi Enemuo, Linda Oge Okoye, Okechukwu Onwuasoigwe
Studies from parts of Nigeria reported low compliance with seatbelt. This study sought to establish driver seatbelt use in Enugu, Nigeria by gender, vehicle type/use and time of day. Observations were done day and night at randomly selected locations. Data were analysed with SPSS version 15. Differences in response were checked with chi-square for trend. Confidence interval was 95% and P value < 0.05 was regarded as significant. Average compliance was 37.6% for the 510 males (85%) and 90 females (15%) observed...
October 17, 2016: International Journal of Injury Control and Safety Promotion
D Labbe, A Rytz, N Godinot, A Ferrage, N Martin
Increasing portion sizes over the last 30 years are considered to be one of the factors underlying overconsumption. Past research on the drivers of portion selection for foods showed that larger portions are selected for foods delivering low expected satiation. However, the respective contribution of expected satiation vs. two other potential drivers of portion size selection, i.e. perceived healthfulness and expected tastiness, has never been explored. In this study, we conjointly explored the role of expected satiation, perceived healthfulness and expected tastiness when selecting portions within a range of six commercial pizzas varying in their toppings and brands...
October 13, 2016: Appetite
Kelly Brown, Charles Sims, Asli Odabasi, Linda Bartoshuk, Patrick Conner, Dennis Gray
The objective of this research was to investigate the acceptability of muscadine grape (Vitis rotundifolia) genotypes (cultivars and selections) and to correlate overall liking to other quality measurements to determine the main drivers of liking. Twenty-two genotypes grown at the Univ. of Georgia-Tifton Campus were evaluated. Four retail commercial grape genotypes (Vitis vinifera and "Concord") were also evaluated for comparison. Panelists familiar with muscadine grapes used the hedonic general labeled magnitude scale (HgLMS, -100 = strongest disliking of any kind ever experienced, +100 = strongest liking of any kind ever experienced) to rate overall liking and the liking of appearance, flavor, pulp texture, and skin texture...
October 14, 2016: Journal of Food Science
Takamichi Yoshizaki, Naoyuki Kimura, Tomoyasu Hirano, Atsushi Yamaguchi, Hideo Adachi
We investigated the clinical picture of non-traumatic acute aortic dissection (AAD) occurring behind the wheel. Between 1990 and 2014, AAD had occurred in 11 patients while driving (nine men, mean age; 58.3 years, seven commercial drivers). The symptoms included chest and/or back pain (n = 9) and syncope (n = 2). One patient with syncope caused a traffic accident. Ten patients had type A dissection (DeBakey type I) and 1 type B dissection. In-hospital mortality was 9.9% (1/11). Our data showed if affected drivers are transported to a hospital in a timely fashion, a good surgical outcome can be expected...
2016: Annals of Vascular Diseases
Andrew L Skowno, Mark W Thompson, Jens Hiestermann, Brad Ripley, Adam G West, William J Bond
Increases in woody plant cover in savanna-grassland environments have been reported on globally for over 50 years and are generally perceived as a threat to rangeland productivity and biodiversity. Despite this few attempts have been made to estimate the extent of woodland increase at a national scale, principally due to technical constraints such as availability of appropriate remote sensing products. In this study we aim to measure the extent to which woodlands have replaced grasslands in South Africa's grassy biomes...
October 12, 2016: Global Change Biology
Jamilah Abdur-Rahim, Yoichi Morales, Pankaj Gupta, Ichiro Umata, Atsushi Watanabe, Jani Even, Takayuki Suyama, Shin Ishii
This paper presents a study on multi-modal human emotional state detection while riding a powered wheelchair (PMV; Personal Mobility Vehicle) in an indoor labyrinth-like environment. The study reports findings on the habituation of human stress response during self-driving. In addition, the effects of "loss of controllability", change in the role of the driver to a passenger, are investigated via an autonomous driving modality. The multi-modal emotional state detector sensing framework consists of four sensing devices: electroencephalograph (EEG), heart inter-beat interval (IBI), galvanic skin response (GSR) and stressor level lever (in the case of autonomous riding)...
2016: PloS One
Dimitrios I Tselentis, George Yannis, Eleni I Vlahogianni
The objective of this paper is to provide a review of the most popular and often implemented methodologies related to Usage-based motor insurance (UBI). UBI schemes, such as Pay-as-you-drive (PAYD) and Pay-how-you-drive (PHYD), are a new innovative concept that has recently started to be commercialized around the world. The main idea is that instead of a fixed price, drivers have to pay a premium based on their travel and driving behaviour. Despite the fact that it has been implemented only for a few years, it appears to be a very promising practice with a significant potential impact on traffic safety as well as on traffic congestion mitigation and pollution emissions reduction...
October 7, 2016: Accident; Analysis and Prevention
Lorena Jiménez-Díaz, Antonio Caballero, Natalia Pérez-Hernández, Ana Segura
Bio-jet fuel has attracted a lot of interest in recent years and has become a focus for aircraft and engine manufacturers, oil companies, governments and researchers. Given the global concern about environmental issues and the instability of oil market, bio-jet fuel has been identified as a promising way to reduce the greenhouse gas emissions from the aviation industry, while also promoting energy security. Although a number of bio-jet fuel sources have been approved for manufacture, their commercialization and entry into the market is still a far way away...
October 10, 2016: Microbial Biotechnology
Eduardo G Bento, Tiago F Grilo, Dániel Nyitrai, Marina Dolbeth, Miguel Ângelo Pardal, Filipe Martinho
Estuarine systems support the life cycle stages of commercially important marine fish and are influenced by large and local-scale climatic patterns. In this study, performed in the Mondego estuary, Portugal, we used an 11-year database (2003-2013) for analyzing the variability in the population of a marine juvenile migrant fish, the European sea bass Dicentrarchus labrax, regarding changes in abundance, population structure, growth rates, secondary production and annual day of peak abundance. Higher densities and production occurred in 2003, but no differences in 0-group growth could be observed...
September 28, 2016: Marine Environmental Research
Alan J Fox, Matthew C Hiemenz, David B Lieberman, Shrey Sukhadia, Barnett Li, Joseph Grubb, Patrick Candrea, Karthik Ganapathy, Jianhua Zhao, David Roth, Evan Alley, Alison Loren, Jennifer J D Morrissette
As our understanding of the driver mutations necessary for initiation and progression of cancers improves, we gain critical information on how specific molecular profiles of a tumor may predict responsiveness to therapeutic agents or provide knowledge about prognosis. At our institution a tumor genotyping program was established as part of routine clinical care, screening both hematologic and solid tumors for a wide spectrum of mutations using two next-generation sequencing (NGS) panels: a custom, 33 gene hematological malignancies panel for use with peripheral blood and bone marrow, and a commercially produced solid tumor panel for use with formalin-fixed paraffin-embedded tissue that targets 47 genes commonly mutated in cancer...
September 20, 2016: Journal of Visualized Experiments: JoVE
Franziska Degenhardt, Barbara Heinemann, Jana Strohmaier, Marvin A Pfohl, Ina Giegling, Andrea Hofmann, Kerstin U Ludwig, Stephanie H Witt, Michael Ludwig, Andreas J Forstner, Margot Albus, Sibylle G Schwab, Margitta Borrmann-Hassenbach, Leonard Lennertz, Michael Wagner, Per Hoffmann, Dan Rujescu, Wolfgang Maier, Sven Cichon, Marcella Rietschel, Markus M Nöthen
Duplications in 16p11.2 are a risk factor for schizophrenia (SCZ). Using genetically modified zebrafish, Golzio and colleagues identified KCTD13 within 16p11.2 as a major driver of the neuropsychiatric phenotype observed in humans. The aims of the present study were to explore the role of KCTD13 in the development of SCZ and to provide a more complete picture of the allelic architecture at this risk locus. The exons of KCTD13 were sequenced in 576 patients. The mutations c.6G>T and c.598G>A were identified in one patient each...
September 23, 2016: Psychiatric Genetics
Jessica Reagh, Martyn Bullock, Juliana Andrici, John Turchini, Loretta Sioson, Adele Clarkson, Nicole Watson, Amy Sheen, Grace Lim, Leigh Delbridge, Stan Sidhu, Mark Sywak, Ahmad Aniss, Phillip Shepherd, Daniel Ng, Paul Oei, Michael Field, Diana Learoyd, Bruce G Robinson, Roderick J Clifton-Bligh, Anthony J Gill
A quarter of patients with medullary thyroid carcinoma (MTC) have germline mutations in the RET proto-oncogene indicating MEN2. Therefore genetic testing is recommended for all patients presenting with MTC. Approximately 40% of MTCs have somatic RET mutations. Somatic mutations in the RAS genes are the next most common driver mutations and appear to be mutually exclusive with germline RET mutation. The single most common somatic RAS mutation is HRASQ61R (c.182A>G), reported in 4.6% to 11% of all MTCs. Mutation-specific immunohistochemistry (IHC) initially developed to identify the NRASQ61R mutation in melanoma (clone SP174) has proven highly sensitive and specific...
September 15, 2016: American Journal of Surgical Pathology
Victoria Villaflor, Brian Won, Rebecca Nagy, Kimberly Banks, Richard B Lanman, AmirAli Talasaz, Ravi Salgia
INTRODUCTION: The potential of oncogene-driven targeted therapy is perhaps most fully realized in non-small cell lung cancer (NSCLC), given the number of genomic targets and approved matched therapies. However, invasive tissue biopsy at the time of each disease progression may not be possible and is associated with high morbidity and cost. Use of newly available "liquid biopsies" can circumvent these issues. RESULTS: 83% of subjects had at least one genomic alteration identified in plasma...
September 1, 2016: Oncotarget
Michael K Lemke, Yorghos Apostolopoulos, Adam Hege, Sevil Sönmez, Laurie Wideman
INTRODUCTION: Long-haul truck drivers in the United States suffer disproportionately high injury rates. Sleep is a critical factor in these outcomes, contributing to fatigue and degrading multiple aspects of safety-relevant performance. Both sleep duration and sleep quality are often compromised among truck drivers; however, much of the efforts to combat fatigue focus on sleep duration rather than sleep quality. Thus, the current study has two objectives: (1) to determine the degree to which sleep impacts safety-relevant performance among long-haul truck drivers; and (2) to evaluate workday and non-workday sleep quality and duration as predictors of drivers' safety-relevant performance...
August 31, 2016: Accident; Analysis and Prevention
Mondher Toumi, Szymon Jarosławski, Toyohiro Sawada, Åsa Kornfeld
The high cost of novel treatments is the major driver of negative or restricted reimbursement decisions by healthcare payers in many countries. Costly drugs can be subject to Market Access Agreements (MAAs), which are financial (Commercial Agreements [CAs]) or outcomes-based (Payment for Performance Agreements [P4Ps] or Coverage with Evidence Development agreements [CEDs]). Outcomes in outcomes-based MAAs are assessed through changes in surrogate endpoints (SEPs) or patient-relevant endpoints (PEPs). In May 2015, we reviewed published and grey literature on MAAs between manufacturers and large, institutionalised payers from all geographical areas, and classified the schemes into CAs, P4Ps and CEDs, as well as by therapeutic area and country...
August 31, 2016: Applied Health Economics and Health Policy
Sarah M Allard, Christopher S Walsh, Anna E Wallis, Andrea R Ottesen, Eric W Brown, Shirley A Micallef
Due to the intimate association between plants and their microbial symbionts, an examination of the influence of agricultural practices on phytobiome structure and diversity could foster a more comprehensive understanding of plant health and produce safety. Indeed, the impact of upstream crop producti006Fn practices cannot be overstated in their role in assuring an abundant and safe food supply. To assess whether fertilizer type impacted rhizosphere and phyllosphere bacterial communities associating with tomato plants, the bacterial microbiome of tomato cv...
August 28, 2016: Science of the Total Environment
Jonathan T Martiniuk, Braydon Pacheco, Gordon Russell, Stephanie Tong, Ian Backstrom, Vivien Measday
Wine is produced by one of two methods: inoculated fermentation, where a commercially-produced, single Saccharomyces cerevisiae (S. cerevisiae) yeast strain is used; or the traditional spontaneous fermentation, where yeast present on grape and winery surfaces carry out the fermentative process. Spontaneous fermentations are characterized by a diverse succession of yeast, ending with one or multiple strains of S. cerevisiae dominating the fermentation. In wineries using both fermentation methods, commercial strains may dominate spontaneous fermentations...
2016: PloS One
Lukas Bubendorf, Reinhard Büttner, Fouad Al-Dayel, Manfred Dietel, Göran Elmberger, Keith Kerr, Fernando López-Ríos, Antonio Marchetti, Büge Öz, Patrick Pauwels, Frédérique Penault-Llorca, Giulio Rossi, Aleš Ryška, Erik Thunnissen
Rearrangements of the ROS1 gene occur in 1-2 % of non-small cell lung cancers (NSCLCs). Crizotinib, a highly effective inhibitor of ROS1 kinase activity, is now FDA-approved for the treatment of patients with advanced ROS1-positive NSCLC. Consequently, focus on ROS1 testing is growing. Most laboratories currently rely on fluorescence in situ hybridisation (FISH) assays using a dual-colour break-apart probe to detect ROS1 rearrangements. Given the rarity of these rearrangements in NSCLC, detection of elevated ROS1 protein levels by immunohistochemistry may provide cost-effective screening prior to confirmatory FISH testing...
August 17, 2016: Virchows Archiv: An International Journal of Pathology
Nicola Stevens, B F N Erasmus, S Archibald, W J Bond
Woody encroachment in 'open' biomes like grasslands and savannahs is occurring globally. Both local and global drivers, including elevated CO2, have been implicated in these increases. The relative importance of different processes is unresolved as there are few multi-site, multi-land-use evaluations of woody plant encroachment. We measured 70 years of woody cover changes over a 1020 km(2) area covering four land uses (commercial ranching, conservation with elephants, conservation without elephants and communal rangelands) across a rainfall gradient in South African savannahs...
September 19, 2016: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
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