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https://www.readbyqxmd.com/read/28827914/extramammary-paget-s-disease-of-the-perianal-region
#1
S Devaji Rao, Meera Govindarajan
Extramammary Paget's disease (EMPD) is uncommon and only a few cases have been reported in the literature. They are identical to the Mammary Paget's disease. This can occur where the apocrine glands are in abundance, more commonly in the genitalia and perianal area. We report here a case of Extramammary Paget's disease in the perianal region. The colourful background of this ulcer is analysed and the literature reviewed.
August 2017: Indian Journal of Surgery
https://www.readbyqxmd.com/read/28819613/aseptic-loosening-after-total-hip-arthroplasty-in-an-acromegalic-patient-a-case-report
#2
Simon Koulischer, Bilal Kapanci, Nicolas Bloemers, Tatiana Charles, Marc Jayankura
INTRODUCTION: Acromegaly is a rare disorder characterized by excess secretion of growth hormone and its principle mediator, insulin-like growth factor-1. Although acromegaly is frequently associated with osteoarthritis, the outcome of arthroplasty in this population is not documented. CASE REPORT: We report here a case of aseptic loosening of an uncemented total hip arthroplasty acetabulum in an acromegalic patient that was revised with a cemented cup. It has been suggested that the incidence of this complication is increased in other pathology with a similarly high bone-turnover (e...
March 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28819009/the-aaa-atpase-p97-a-cellular-multitool
#3
REVIEW
Lasse Stach, Paul S Freemont
The AAA+ (ATPases associated with diverse cellular activities) ATPase p97 is essential to a wide range of cellular functions, including endoplasmic reticulum-associated degradation, membrane fusion, NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) activation and chromatin-associated processes, which are regulated by ubiquitination. p97 acts downstream from ubiquitin signaling events and utilizes the energy from ATP hydrolysis to extract its substrate proteins from cellular structures or multiprotein complexes...
August 17, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28815760/impact-microindentation-consistency-of-serial-measurements-and-alterations-in-patients-with-paget-s-disease-of-the-tibia
#4
Frank Malgo, Neveen A T Hamdy, Socrates E Papapoulos, Natasha M Appelman-Dijkstra
Impact microindentation is a new technique for the in vivo measurement of tissue-level properties of cortical bone in humans. To address issues related to the proper application of IMI in clinical practice and to directly examine cortical bone properties in patients with tibia pathology, we studied 11 subjects without tibia pathology and 9 patients with Paget's disease of the tibia in biochemical remission after bisphosphonate treatment. Serial indentations in the tibiae of both legs were performed in all subjects by a single operator until 10 adequate measurements were obtained in each tibia...
August 16, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28814210/advanced-paget-disease-of-bone
#5
Kay Hau Choy, Sumaya Alukaidey
No abstract text is available yet for this article.
August 21, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28806539/clinical-and-microstructural-findings-in-paget-disease-of-the-entire-mandible
#6
Reinhard E Friedrich, Andreas M Luebke, Michael Amling, Till Koehne
Paget disease of bone (PDB) is a chronic progressive bone disorder characterized by localized increased bone turnover and focal areas of woven bone formation. Although skull involvement is common, PDB very rarely affects the mandible. This report describes the clinical and histologic findings in a 75-year-old patient with PDB involving the mandible. Microstructural analyses showed an altered quality of the bone microstructure and calcium depletion of the affected bone. Differential diagnosis of PDB affecting the mandible is discussed...
July 20, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28800754/current-concepts-in-bone-metastasis-contemporary-therapeutic-strategies-and-ongoing-clinical-trials
#7
REVIEW
Andrew S Gdowski, Amalendu Ranjan, Jamboor K Vishwanatha
BACKGROUND: Elucidation of mechanisms regulating bone metastasis has progressed significantly in recent years and this has translated to many new therapeutic options for patients with bone metastatic cancers. However, the rapid rate of progress in both the basic science literature and therapies undergoing clinical trials makes staying abreast with current developments challenging. This review seeks to provide an update on the current state of the science in bone metastasis research and give a snap shot of therapies in clinical trials for bone metastatic cancer...
August 11, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/28780255/paget-s-disease-of-bone
#8
Tim Cundy
Paget's disease is a chronic focal high turnover bone disorder that is primarily present in middle-aged or older adults. It seems to be restricted to humans and has no clear parallels with other diseases. Although much has been learnt about its pathology and epidemiology, and treatment is now highly effective we still lack a complete understanding of its etiology and biology. This review focusses on the natural history of the disorder, in particular its changing epidemiology, recent discoveries about its genetic basis and current approaches to diagnosis and treatment...
July 4, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28768671/paget-schroetter-syndrome-complicated-by-an-incidental-pulmonary-embolism
#9
Jakub Kaczynski, Joseph Sathiananthan
A young man presented with the severe right upper limb swelling following a heavy weight lifting that was thought to be caused by a biceps tendon rupture. However, subsequent investigations confirmed the diagnosis of Paget-Schroetter syndrome that was associated with an incidental pulmonary embolism. The patient underwent a successful thrombolysis followed by a surgical thoracic outlet decompression. Overall, the patient has made a good recovery.
August 2, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28748610/using-family-and-staff-experiences-of-a-botulinum-toxin-a-service-to-improve-service-quality
#10
K L O Burton, K Bau, J Lewis, K R Aroyan, B Botha, A G M Botman, K Stewart, M-C A Waugh, S P Paget
BACKGROUND: The decision for families to proceed with botulinum toxin-A (BoNT-A) injections for managing childhood conditions involving hypertonia can be complex. Family-centred care is a service model that facilitates supporting families in this decision-making process. Understanding families' experiences of services is critical to developing family-centred care. The aim of this project was therefore to increase understanding of the experiences of families of children attending a BoNT-A service in order to improve the service and its family-centred approach to care...
July 26, 2017: Child: Care, Health and Development
https://www.readbyqxmd.com/read/28748454/recurrence-with-pagetoid-spread-arising-17%C3%A2-years-after-surgery-for-intramucosal-rectal-cancer-a-case-report
#11
Taichi Matsubara, Yuta Kasagi, Kippei Ogaki, Yu Nakaji, Ryota Nakanishi, Yuichiro Nakashima, Masahiko Sugiyama, Hideto Sonoda, Hiroshi Saeki, Eiji Oki, Yoshihiko Maehara
BACKGROUND: Perianal Paget's disease (pPD) is uncommon, with only about 180 cases documented in the literature. Anorectal carcinoma with pagetoid spread is even rarer. CASE PRESENTATION: An 81-year-old woman underwent rectal cancer extirpation with a transanal approach 17 years prior. She has since undergone two reoperations for local rectal cancer recurrence. Then, warts frequently appeared on the vulva on several occasions. Warts appeared on the vulva 1 year ago, which were diagnosed as pPD by biopsy...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28731239/new-technology-discloses-the-tumour-margin-of-extramammary-paget-disease
#12
N Hatta
No abstract text is available yet for this article.
July 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28729083/urschel-s-sign-in-paget-schroetter-syndrome
#13
Sean M Lawless, Rohan Samson
No abstract text is available yet for this article.
July 17, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28721304/imaging-features-of-paget-s-disease-on-11-c-choline-pet-ct
#14
Cameron E Leitch, Ajit H Goenka, Benjamin M Howe, Stephen M Broski
The purpose of this study was to investigate the appearance of Paget's disease (PD) on (11)C choline PET/CT and correlate these findings to serum alkaline phosphatase (ALP) level and skeletal scintigraphy. With IRB approval, our institutional (11)C choline PET/CT database (9/2005-6/2015) was searched for patients with PD. Site of osseous involvement, CT appearance, and multiple semi-quantitative measures were measured and correlated with ALP and degree of uptake on bone scan. Our search identified 10 males (mean age 79...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28712271/ectopic-extramammary-paget-s-disease-on-the-scalp
#15
Evgenia Balamonti, Eftychia Platsidaki, Anargyros Kouris, Akrivi Kostopoulou, Sofia Pappa, Georgios Kontochristopoulos
No abstract text is available yet for this article.
July 13, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28707179/the-grades-that-clinical-teachers-give-students-modifies-the-grades-they-receive
#16
Michael Paget, Gurbir Brar, Pamela Veale, Kevin Busche, Sylvain Coderre, Wayne Woloschuk, Kevin McLaughlin
Prior studies have shown a correlation between the grades students receive and how they rate their teacher in the classroom. In this study, the authors probe this association on clinical rotations and explore potential mechanisms. All In-Training Evaluation Reports (ITERs) for students on mandatory clerkship rotations from April 1, 2013 to January 31, 2015 were matched with the corresponding student's rating of their teacher (SRT). The date and time that ITERs and SRTs were submitted was used to divide SRTs into those submitted before versus after the corresponding ITER was submitted...
July 13, 2017: Advances in Health Sciences Education: Theory and Practice
https://www.readbyqxmd.com/read/28706280/radiation-induced-changes-in-the-glycome-of-endothelial-cells-with-functional-consequences
#17
Cyprien Jaillet, Willy Morelle, Marie-Christine Slomianny, Vincent Paget, Georges Tarlet, Valérie Buard, Sonia Selbonne, Fanny Caffin, Emilie Rannou, Pierre Martinez, Agnès François, François Foulquier, Fabrice Allain, Fabien Milliat, Olivier Guipaud
As it is altered by ionizing radiation, the vascular network is considered as a prime target in limiting normal tissue damage and improving tumor control in radiation therapy. Irradiation activates endothelial cells which then participate in the recruitment of circulating cells, especially by overexpressing cell adhesion molecules, but also by other as yet unknown mechanisms. Since protein glycosylation is an important determinant of cell adhesion, we hypothesized that radiation could alter the glycosylation pattern of endothelial cells and thereby impact adhesion of circulating cells...
July 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28701678/paget-schroetter-syndrome-in-a-baseball-pitcher
#18
Shusuke Yagi, Minoru Mitsugi, Teruaki Sangawa, Masashi Akaike, Masataka Sata
Paget-Schroetter syndrome (PSS) is thrombosis of the deep veins draining the upper extremity due to anatomic abnormalities of the thoracic outlet that cause subclavian compression and subsequent thrombosis, leading to thrombus formation in the subclavian vein. Vigorous arm activity in sports is a known risk factor. Here, we report a case of Paget-Schroetter syndrome in a 31-year-old male non-professional baseball pitcher.
August 3, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28695812/clinical-and-sonographic-features-of-mammary-paget-s-disease
#19
Yao Wei, Qingli Zhu, Jianchu Li, Yuxin Jiang
Objective To summarize the clinical and sonographic features of mammary Paget's disease (MPD). Methods Totally 34 female patients with pathologically confirmed MPD were retrospectively recruited. According to diagnosis,the clinical data and sonographic findings were reviewed and analyzed. Results Among these 34 patients,7 patients had single MPD; in the remaining 27 patients,16 were accompanied by invasive ductal carcinoma (IDC),7 by ductal carcinoma in situ (DCIS),3 by both IDC and DCIS,and 1 by other pathologic types of carcinoma...
June 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28694461/endothelial-hey2-deletion-reduces-endothelial-to-mesenchymal-transition-and-mitigates-radiation-proctitis-in-mice
#20
Elodie Mintet, Jérémy Lavigne, Vincent Paget, Georges Tarlet, Valérie Buard, Olivier Guipaud, Jean-Christophe Sabourin, Maria-Luisa Iruela-Arispe, Fabien Milliat, Agnès François
The current study evaluated the role of Hey2 transcription factor in radiation-induced endothelial-to-mesenchymal transition (EndoMT) and its impact on radiation-induced tissue damage in mice. Phenotypic modifications of irradiated, Hey2 siRNA- and Hey2 vector plasmid-transfected human umbilical vein endothelial cells (HUVECs) resembling EndoMT were monitored by qPCR, immunocytochemistry and western blots. Subsequently, in mice, a Cre-LoxP strategy for inactivation of Hey2 specifically in the endothelium was used to study the biological consequences...
July 10, 2017: Scientific Reports
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