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https://www.readbyqxmd.com/read/29627436/ala-pdt-as-palliative-care-in-a-patient-with-secondary-perineum-empd
#1
Shuzhan Shen, Guolong Zhang, Peiru Wang, Yunfeng Zhang, Uma Keyal, Jie Ji, Xiuli Wang
Extramammary Paget's disease (EMPD) is a rare intraepithelial neoplasm arising in apocrine rich area of the skin. It is divided into primary and secondary EMPD based on whether there is an underlying malignancy, either local apocrine cancers or distant neoplasms. Therefore, all patients with EMPD should undergo an extensive and targeted cancer workup, depending on the histological staining pattern and the location. Surgical removal is considered the mainstay of treatment for patients with EMPD. Herein, we present a case of secondary EMPD where photodynamic therapy was effective in terms of improving symptoms and quality of life...
April 5, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29624915/present-and-changing-trends-in-surgical-modalities-and-neoadjuvant-chemotherapy-administration-for-female-breast-cancer-in-beijing-china-a-10-year-2006-2015-retrospective-hospitalization-summary-report-based-study
#2
Xiaoyuan Bao, Kexin Sun, Xin Tian, Qiongzhou Yin, Meng Jin, Na Yu, Hanfang Jiang, Jun Zhang, Yonghua Hu
BACKGROUND: This study was conducted to describe present and changing trends in surgical modalities and neoadjuvant chemotherapy (NACT) in female breast cancer patients in China from 2006 to 2015. METHODS: Data of 44 299 female breast cancer patients from 15 tertiary hospitals in Beijing were extracted from hospitalization summary reports. Surgeries were categorized into five modalities: breast-conserving surgery (BCS), simple mastectomy (SM), modified radical mastectomy (MRM), radical mastectomy (RM), and extensive radical mastectomy (ERM)...
April 6, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29620995/3-versus-6-months-of-oxaliplatin-based-adjuvant-chemotherapy-for-patients-with-stage-iii-colon-cancer-disease-free-survival-results-from-a-randomized-open-label-international-duration-evaluation-of-adjuvant-idea-france-phase-iii-trial
#3
Thierry André, Dewi Vernerey, Laurent Mineur, Jaafar Bennouna, Jérôme Desrame, Roger Faroux, Serge Fratte, Marine Hug de Larauze, Sophie Paget-Bailly, Benoist Chibaudel, Jeremie Bez, Jérôme Dauba, Christophe Louvet, Céline Lepere, Olivier Dupuis, Yves Becouarn, May Mabro, Joëlle Egreteau, Olivier Bouche, Gaël Deplanque, Marc Ychou, Marie Pierre Galais, François Ghiringhelli, Louis Marie Dourthe, Jean-Baptiste Bachet, Ahmed Khalil, Franck Bonnetain, Aimery de Gramont, Julien Taieb
Purpose Reduction of adjuvant treatment duration may decrease toxicities without loss of efficacy in stage III colon cancer. This could offer clear advantages to patients and health care providers. Methods In International Duration Evaluation of Adjuvant Chemotherapy (IDEA) France, as part of the IDEA international collaboration, patient with colon cancer patients were randomly assigned to 3 and 6 months of modified FOLFOX6 (mFOLFOX6: infusional fluorouracil, leucovorin, and oxaliplatin) or capecitabine plus oxaliplatin (CAPOX) by physician choice...
April 5, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29606821/pagetoid-bowen-disease-initially-misdiagnosed-as-ectopic-extramammary-paget-s-disease
#4
Jaewon Lee, Minwoo Kim, Jungyoon Moon, Hyun-Sun Yoon, Soyun Cho, Hyun-Sun Park
Pagetoid Bowen disease is a histological variant of Bowen disease which demonstrates large pale staining cells (pagetoid cells). It requires differential diagnosis from other cutaneous malignancies with similar patterns, such as extramammary Paget's disease (EMPD) and Pagetoid melanoma in situ . Herein, we report a case of Pagetoid Bowen disease which was initially misdiagnosed as ectopic EMPD.
April 2018: Annals of Dermatology
https://www.readbyqxmd.com/read/29575944/the-diagnosis-and-management-of-extramammary-paget-s-disease
#5
Takamichi Ito, Yumiko Kaku-Ito, Masutaka Furue
Extramammary Paget's disease (EMPD) is a rare neoplastic condition that commonly affects the anogenital area in the elderly. Owing to its low incidence, limited data regarding EMPD's diagnosis and treatment have been available. This review article aims to explore the current knowledge of EMPD to improve the management of this disease. Areas covered: This review outlines the diagnosis and management of EMPD. Articles on this issue that had been published in PubMed were identified and surveyed. We provide an overview of the reported studies, focusing on the recent advances in this field...
March 27, 2018: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/29575853/paget-disease-of-bone-among-hospitalized-patients-in-poland
#6
Krzysztof Kanecki, Aneta Nitsch-Osuch, Paweł Goryński, Magdalena Bogdan, Patryk Tarka, Piotr Zbigniew Tyszko
INTRODUCTION: Paget's disease (PDB) is a focal disorder of bone remodeling that occurs commonly in older people with decreasing prevalence reported in European countries. This disease is most often asymptomatic, but it can cause a variety of medical complications resulting in considerable morbidity and reduced quality of life. There is little information regarding the epidemiology of PDB in Poland. To the best of the authors' knowledge, this is the first large epidemiological analysis of this disease in Poland...
March 14, 2018: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/29569629/corrigendum-metastatic-extramammary-paget-s-disease-pathogenesis-and-novel-therapeutic-approach
#7
Keitaro Fukuda, Takeru Funakoshi
[This corrects the article on p. 38 in vol. 8, PMID: 29503810.].
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29568001/dysosteosclerosis-is-also-caused-by-tnfrsf11a-mutation
#8
Long Guo, Nursel H Elcioglu, Ozge K Karalar, Mert O Topkar, Zheng Wang, Yuma Sakamoto, Naomichi Matsumoto, Noriko Miyake, Gen Nishimura, Shiro Ikegawa
Dysosteosclerosis (DOS) is a form of sclerosing bone disease characterized by irregular osteosclerosis and platyspondyly. Its mode of inheritance is autosomal recessive. SLC29A3 mutations have been reported as the causal gene in two DOS families, however, genetic heterogeneity has been suggested. By whole-exome sequencing in a Turkish patient with DOS, we found a novel splice-site mutation in TNFRSF11A. TNFRSF11A mutations have previously been reported in two autosomal dominant diseases (osteolysis, familial expansile and Paget disease of bone 2, early-onset) and an autosomal recessive disease (osteopetrosis, autosomal recessive 7)...
March 22, 2018: Journal of Human Genetics
https://www.readbyqxmd.com/read/29566925/genital-diseases-in-the-mature-woman
#9
Natalie Matthews, Vivian Wong, Joe Brooks, George Kroumpouzos
Vulvovaginal conditions are common in mature women. This reflects age-related changes in immunity and skin barrier function of vulvovaginal tissues. Vaginal atrophy is commonly complicated by dryness and inflammation, which makes postmenopausal atrophic vaginitis a virtually ubiquitous condition. The differential of vaginitis includes inflammatory, infectious, and malignant diseases, plus drug hypersensitivity. Atrophic vaginitis is treated with estrogen replacement therapy. Vulvovaginal malignant melanoma occurs predominantly in postmenopausal women and carries a poor prognosis...
March 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/29555685/p62-sequestosome-1-deficiency-accelerates-osteoclastogenesis-in-vitro-and-leads-to-paget-s-disease-like-bone-phenotypes-in-mice
#10
Frank Zach, Franziska Polzer, Alexandra Mueller, André Gessner
The sequestosome 1 gene encodes the p62 protein and is the major genetic risk factor associated with Paget's disease of bone. In 2004, p62 was reported to up-regulate osteoclast differentiation by activating the transcription factors Nfatc1 and NF-κB. Here, we characterized the osteoclastogenic potential of murine p62-/- -derived cells compared with WT cells. Our data confirmed previous findings indicating that that p62 is induced during murine osteoclast differentiation. Surprisingly, an indispensable role for p62 in i n vitro osteoclast differentiation was not reproducible, since p62-deficient osteoclasts exhibited robust activation of Nfatc1, NF-κB, and osteoclast marker enzymes...
March 19, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29552239/paget-schroetter-syndrome-with-bilateral-pulmonary-emboli
#11
Garrison Glavich, Jeffrey Gourley, Victor Fong
Paget-Schroetter syndrome, also known as effort thrombosis, is a relatively rare disease process characterized by primary thrombosis to the subclavian and axillary veins. It usually presents in younger individuals, commonly affecting the dominant side upper extremity, and the diagnosis relies on a combination of imaging, laboratory tests, and clinical presentation. Upper extremity deep vein thrombosis can also lead to pulmonary emboli, as in this case of a 20-year-old female discovered to have right sided Paget-Schroetter syndrome...
February 2018: Radiology case reports
https://www.readbyqxmd.com/read/29551057/paget-disease-in-a-radius
#12
Ruiguo Zhang, Guizhi Zhang, Renfei Wang, Qiang Jia, Jian Tan
No abstract text is available yet for this article.
March 19, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29544749/clinical-utility-of-bone-turnover-markers-in-the-management-of-common-metabolic-bone-diseases-in-adults
#13
REVIEW
Paul Glendenning, S A Paul Chubb, Samuel Vasikaran
Bone turnover marker (BTMs) concentrations in blood and urine reflect bone-remodelling activity, and may be useful adjuncts in the diagnosis and management of metabolic bone diseases. Newer biomarkers, mainly bone regulatory proteins, are currently being investigated to elucidate their role in bone metabolism and disease and may in future be useful in clinical diagnosis and management of metabolic bone disease. BTM concentrations increase around menopause in women, and at a population level the degree of increase in BTMs reflect bone loss...
March 12, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29542074/esophageal-paget-s-disease-secondary-to-hypopharyngeal-carcinoma-a-case-report
#14
Holly White, Simi George, James Gossage, Fuju Chang
No abstract text is available yet for this article.
March 15, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29541783/sir-james-paget-contributions-of-a-surgeon-and-pathologist
#15
Manthan Patel, Varun Ayyaswami, Arpan V Prabhu
No abstract text is available yet for this article.
March 1, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29538255/the-role-of-radiotherapy-in-extramammary-paget-disease-a-systematic-review
#16
L Tagliaferri, C Casà, G Macchia, A Pesce, G Garganese, B Gui, G Perotti, S Gentileschi, F Inzani, R Autorino, S Cammelli, A G Morganti, V Valentini, M A Gambacorta
OBJECTIVE/PURPOSE: Extramammary Paget disease (EMPD) is a rare neoplasm of the skin generally affecting the anogenital area. Because of the low-frequency of the disease, no specific guidelines about the treatment strategy are available. Surgery is the recommended therapy for resectable and localized disease, but several other local treatments have been reported such as radiotherapy (RT). Most articles report small retrospective studies, referring to patients treated decades ago with large heterogeneity in terms of RT dose and technique...
March 17, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29536970/successful-treatment-of-metastatic-extramammary-paget-s-disease-with-pemetrexed-monotherapy-systematically-and-5-fluorouracil-topically
#17
Kexu Chen, Hanlin Liang, Jiewen Peng, Yanfang Zheng
Advanced extramammary Paget's disease does not have a standardized treatment guideline as its incidence is low and has been rarely reported in literature. Here we describe a case of metastatic extramammary Paget's disease successfully treated with topical 5-fluorouracil (5-FU) and systemic pemetrexed. The therapy was safe without any appreciable adverse effects like diarrhea, rash, neutropenia or fatigue; maintaining remission for more than 6 months. Thus, we propose 5-FU and pemetrexed as the first-line therapy for advanced extramammary Paget's disease, especially for aged patients with unresectable skin lesions...
March 12, 2018: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/29517496/intraoperative-immunostaining-for-cytokeratin-7-during-mohs-micrographic-surgery-demonstrates-low-local-recurrence-rates-in-extramammary-paget-s-disease
#18
Ali A Damavandy, Vitaly Terushkin, John A Zitelli, David G Brodland, Christopher J Miller, Jeremy R Etzkorn, Thuzar M Shin, Mark A Cappel, Mario Mitkov, Ali Hendi
BACKGROUND: Extramammary Paget's disease (EMPD) is a rare intraepithelial malignancy with high recurrence rates following standard surgical treatments, ranging from 22% to 60% in large retrospective reviews. OBJECTIVE: To evaluate the local recurrence rate of Mohs micrographic surgery (MMS) supplemented with intraoperative immunohistochemistry for cytokeratin-7 (MMS + CK-7) for primary and recurrent EMPD. MATERIALS AND METHODS: Retrospective, multi-center, cross-sectional study of patients treated using MMS + CK-7...
March 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29507011/extramammary-paget-s-disease-of-the-scrotum-with-complete-response-to-imiquimod-and-photodynamic-therapy
#19
Tyler M Bauman, Ilana S Rosman, David M Sheinbein
Extramammary Paget's disease (EMPD) is a rare intraepithelial neoplasm with an extremely variable clinical course. The objective of this study was to determine if combination imiquimod and photodynamic therapy could induce remission of EMPD. A 69-year-old man with EMPD was treated with topical imiquimod 5% cream at night for 5 days per week for 1 month, followed by 2 months of 5% imiquimod for three nights a week. For the following 6 months, monthly 5-aminolevulinic acid photodynamic therapy was added. After 6 months, imiquimod was discontinued and the patient continued to be treated with quarterly photodynamic therapy...
March 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29503810/metastatic-extramammary-paget-s-disease-pathogenesis-and-novel-therapeutic-approach
#20
REVIEW
Keitaro Fukuda, Takeru Funakoshi
Extramammary Paget's disease (EMPD) is a rare, slow-growing, cutaneous adenocarcinoma that usually originates in the anogenital area and axillae outside the mammary glands. EMPD mostly progresses slowly and is often diagnosed as carcinoma in situ ; however, upon becoming invasive, it promptly and frequently metastasizes to regional lymph nodes, leading to subsequent distant metastasis. To date, several chemotherapy regimens have been used to treat metastatic EMPD; however, they present limited effect and patients with distant metastasis exhibit a poor prognosis...
2018: Frontiers in Oncology
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