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https://www.readbyqxmd.com/read/29028244/celebrating-eupha-s-25th-anniversary
#1
Natasha Azzopardi-Muscat, Martin McKee, Peter Allebeck, Dineke Zeegers Paget
No abstract text is available yet for this article.
October 1, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/29028234/what-role-can-civil-society-organizations-have-in-european-health-policy
#2
Dineke Zeegers Paget, Nina Renshaw, Maaike Droogers
Over the years, the main European institutions active in health [European Union, and the Regional Office for Europe of the World Health Organization (WHO)] have played active roles in policy for public health in Europe. Yet, more recent developments have called into question the place of public health on the European political agenda. In this article, we reflect on how European health policy is set and what the role of civil society organizations (CSOs) can or should be, by showcasing two European associations as examples of how to influence European health policy development and implementation...
October 1, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/29019314/authors-reply-geographic-resolution-of-surveillance-data-and-influenza-prevention-in-large-countries
#3
Saverio Caini, Wladimir J Alonso, Clotilde El-Guerche Séblain, François Schellevis, John Paget
No abstract text is available yet for this article.
October 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28993189/effect-of-genetic-variants-of-optn-in-the-pathophysiology-of-paget-s-disease-of-bone
#4
Iris A L Silva, Natércia Conceição, Édith Gagnon, Helena Caiado, Jacques P Brown, Fernando Gianfrancesco, Laëtitia Michou, M Leonor Cancela
Paget's disease of bone (PDB) is the second most frequent metabolic bone disease after osteoporosis. Genetic factors play an important role in PDB, but to date PDB causing mutations were identified only in the Sequestosome 1 gene at the PDB3 locus. OPTN has been recently associated with PDB, however little is known about the effect of genetic variants in this gene in PDB pathophysiology. By sequencing OPTN in SQSTM1 non-carriers PDB patients we found 16 SNPs in regulatory, coding and non-coding regions. One of those was found to be associated with PDB in our cohort - rs2234968...
October 6, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28992669/-a-case-of-secondary-extramammary-paget-s-disease-aroundthe-cutaneous-stoma-after-radical-cystectomy
#5
Sohei Kanda, Kazutoshi Okubo, Takuya Hida, Jin Kono, Takeshi Takahashi, Kenji Mitsumori, Toshihide Shimada, Kazuo Nishimura
We present a case of secondary extramammary Paget's disease around the cutaneous ureterostomy stoma after radical cystectomy. An 85-year-old man with bacillus calmette-guérin refractory high-grade urothelial carcinoma underwent radical cystectomy and cutaneous ureterostomy construction. After right ureter cancer diagnosis, he underwent right nephroureterectomy 3 years after the cystectomy. He developed refractory dermatitis around the cutaneous stoma 1 year after the nephroureterectomy. Skin biopsy revealed secondary extramammary Paget's disease, cured by skin excision around the cutaneous stoma and skin grafting...
September 2017: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/28986775/timeline-metastatic-progression-in-the-wake-of-the-%C3%A2-%C3%A2-seed-and-soil%C3%A2-%C3%A2-theory
#6
Aymeric Amelot, Louis-Marie Terrier, Jean-Jacques Mazeron, Charles-Ambroise Valery, Philippe Cornu, Alexandre Carpentier, Marc Leveque
Little is known about the natural history of cancer and its evolution to metastasis. Paget was the first to postulate the important role played by microenvironment in metastasis progression. Since, the concept of his "seed and soil" theory has been supported and confirmed. Understanding the chronology and natural course that underlie metastasis is mandatory to deepen this concept and to progress in the development of novel therapeutic strategies. A total of 413 patients who underwent treatment for brain metastasis (2013-2016) were included...
October 6, 2017: Medical Oncology
https://www.readbyqxmd.com/read/28976448/invasive-paget-disease-of-the-vulva
#7
Chiara Borghi, Giorgio Bogani, Antonino Ditto, Fabio Martinelli, Mauro Signorelli, Valentina Chiappa, Cono Scaffa, Stefania Perotto, Umberto Leone Roberti Maggiore, Dario Recalcati, Domenica Lorusso, Francesco Raspagliesi
OBJECTIVE: Extramammary Paget disease of the vulva (EPDV) is a rare occurrence with an indolent and relapsing course. Progression to invasion occurs in 4% to 19% of cases. The aim of this study is to report clinical-pathological features and outcomes of patients treated for invasive EPDV. METHODS: Data of consecutive patients treated between 2000 and 2017 for invasive EPDV were reviewed. RESULTS: Among 79 patients with EPDV, 10 (12.7%) presented a microinvasive or invasive form at first diagnosis or during follow-up...
October 3, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28970065/valocin-containing-protein-vcp-is-a-novel-iq-motif-containing-gtpase-activating-protein-1-iqgap1-interacting-protein
#8
Norimichi Itoh, Taku Nagai, Takashi Watanabe, Kentaro Taki, Toshitaka Nabeshima, Kozo Kaibuchi, Kiyofumi Yamada
Scaffold proteins play a pivotal role in making protein complexes, and organize binding partners into a functional unit to enhance specific signaling pathways. IQ motif-containing GTPase activating protein 1 (IQGAP1) is an essential protein for spine formation due to its role in scaffolding multiple signal complexes. However, it remains unclear how IQGAP1 interacts within the brain. In the present study, we screened novel IQGAP1-interacting proteins by a proteomic approach. As a novel IQGAP1-interacting protein, we identified valocin-containing protein (VCP) which is a causative gene in patients with inclusion body myopathy with Paget's disease of bone and frontotemporal dementia (IBMPFD)...
September 29, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28969735/langerhans-cell-histiocytosis-involving-both-jaws-in-an-adult
#9
Hira Salam, Ruqaiya Shahid, Talat Mirza
Langerhans cell histiocytosis (LCH) is the latest terminology for a disorder of reticulo-endothelial system, previously known as histiocytosis X, and marked by aberrant proliferation of bone marrow derived Langerhans cells with variable inflammatory infiltrate including neutrophils, lymphocytes, plasma cells, eosinophils, and multinucleated giant cells. Although rare, the disorder frequently inflicts children with peak incidence recorded in 2-4 years age group. LCH is rare in adults. A22-year adult male presented with the complaint of teeth mobility...
September 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28968976/the-distinct-clinical-features-of-giant-cell-tumor-of-bone-in-pagetic-and-non-pagetic-patients-are-associated-with-genetic-biochemical-and-histological-differences
#10
Giuseppina Divisato, Federica Scotto di Carlo, Laura Pazzaglia, Riccardo Rizzo, Domenico A Coviello, Maria Serena Benassi, Piero Picci, Teresa Esposito, Fernando Gianfrancesco
Giant Cell Tumor of Bone (GCT) is a tumor characterized by neoplastic mesenchymal stromal cells and a high number of osteoclast-like multinucleated giant cells. Rarely, GCT could arise in bones affected by Paget's disease of bone (GCT/PDB). Although it is already known that GCT/PDB and GCT show a different clinical profile regarding the age-onset and skeletal localization, our deep clinical comparison between the two GCT/PDB and GCT cohorts, permitted us to identify additional differences (e.g. focality, ALP serum levels, the 5-year survival rate and the familial recurrence), strongly suggesting a different molecular basis...
September 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28967630/determinants-of-quality-of-life-in-paget-s-disease-of-bone
#11
Gláucio Ricardo Werner de Castro, Silvania Ana Fernandes de Castro, Ivanio Alves Pereira, Adriana Fontes Zimmermann, Maria Amazile Toscano, Fabricio Souza Neves, Maria Aparecida Scottini, Juliane Paupitz, Julia Salvan da Rosa, Ziliani Buss, Tânia Silvia Fröde
OBJECTIVE: To evaluate the parameters associated with quality of life in patients with Paget's disease of bone. METHODS: Patients with Paget's disease of bone were evaluated with SF-36 and WHOQOL-bref questionnaires. Patients with other diseases that could cause significant impairment of their quality of life were excluded. We searched for correlations between the results and: age, time from diagnosis, type of involvement, pain related to Paget's disease of bone, limitation to daily activities, deformities, bone specific alkaline phosphatase, the extent of involvement and treatment...
September 26, 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/28965204/dental-manifestations-of-pediatric-bone-disorders
#12
REVIEW
Juan F Yepes
PURPOSE OF REVIEW: Several bone disorders affecting the skeleton often are manifest in the maxillofacial region. This review presents the most common bone disorders in children and their dental-oral manifestations: fibrous dysplasia, Paget's disease, osteogenesis imperfecta, renal osteodystrophy, hypophosphatasia, and osteoporosis. The specific intraoral characteristics will reviewed in detail. RECENT FINDINGS: Recent studies confirmed the close relationship between the mandible and the maxilla with the most prevalent systemic bone disorders in children...
September 30, 2017: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/28961883/european-public-health-news
#13
Dineke Zeegers Paget
No abstract text is available yet for this article.
August 1, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28961876/health-assessments-for-health-governance-concepts-and-methodologies
#14
Rainer Fehr, Kristina Alexanderson, Carlo Favaretti, Judith de Jong, Giuseppe La Torre, Tek-Ang Lim, Piedad Martin-Olmedo, Odile C L Mekel, Kai Michelsen, Nicole Rosenkötter, Marieke Verschuuren, Chiara de Waure, Dineke Zeegers Paget
Background: For better supporting the science-governance interface, the potential of health assessments appears underrated. Aims: To identify what various types of health assessment have in common; how they differ; which assessment(s) to apply for which purpose; and what needs and options there are for future joint development. Methods: This review is based on five types of health assessment: monitoring/surveillance/reporting, assessment of health impact, of health technology, of health systems performance, health-related economic assessment...
August 1, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28960299/mohs-micrographic-surgery-for-treating-erosive-adenoma-of-the-nipple-a-case-report-and-review-of-the-literature
#15
Israel Barco, MCarmen Vidal, Manel Fraile, Emili Masferrer, Leo Barco, Didac Barco, Cinthya J Baez, Nuria Giménez, Antoni Pessarrodona, Antonio García-Fernández
BACKGROUND: Erosive adenoma of the nipple (EAN) is a benign condition that involves major ducts of the nipple. Its clinical presentation may resemble other disorders. Complete removal of the nipple is often suggested because of frequent relapse. However, adverse cosmetic and functional results have prompted clinicians to look for other more conservative options. AIMS: To present a case of EAN successfully treated using Mohs micrographic surgery (MMS) and summarize differential diagnosis and treatment...
September 27, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28957494/european-public-health-news
#16
Dineke Zeegers Paget
No abstract text is available yet for this article.
October 1, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28956065/the-peritoneal-soil-for-a-cancerous-seed-a-comprehensive-review-of-the-pathogenesis-of-intraperitoneal-cancer-metastases
#17
REVIEW
Justyna Mikuła-Pietrasik, Paweł Uruski, Andrzej Tykarski, Krzysztof Książek
Various types of tumors, particularly those originating from the ovary and gastrointestinal tract, display a strong predilection for the peritoneal cavity as the site of metastasis. The intraperitoneal spread of a malignancy is orchestrated by a reciprocal interplay between invading cancer cells and resident normal peritoneal cells. In this review, we address the current state-of-art regarding colonization of the peritoneal cavity by ovarian, colorectal, pancreatic, and gastric tumors. Particular attention is paid to the pro-tumoral role of various kinds of peritoneal cells, including mesothelial cells, fibroblasts, adipocytes, macrophages, the vascular endothelium, and hospicells...
September 27, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28946870/possible-explanations-for-why-some-countries-were-harder-hit-by-the-pandemic-influenza-virus-in-2009-a-global-mortality-impact-modeling-study
#18
Kathleen F Morales, John Paget, Peter Spreeuwenberg
BACKGROUND: A global pandemic mortality study found prominent regional mortality variations in 2009 for Influenza A(H1N1)pdm09. Our study attempts to identify factors that explain why the pandemic mortality burden was high in some countries and low in others. METHODS: As a starting point, we identified possible risk factors worth investigating for Influenza A(H1N1)pdm09 mortality through a targeted literature search. We then used a modeling procedure (data simulations and regression models) to identify factors that could explain differences in respiratory mortality due to Influenza A(H1N1)pdm09...
September 25, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28945622/clinical-benefits-of-preoperative-conventional-fluorescence-diagnosis-in-surgical-treatment-of-extramammary-paget-disease
#19
Miaojian Wan, Han Ma, Yue Zhao, Lin Xie, Zhirui Chen
BACKGROUND: In extramammary Paget disease (EMPD), initial margins of surgical excision are difficult to determine preoperatively. Fluorescence diagnosis (FD) may have utility as a noninvasive method for delineating tumor boundaries. OBJECTIVE: The relationship between FD-delineated borders and results of multiple scouting biopsies (MSBs) in EMPD was investigated, evaluating the potential clinical role of FD. MATERIALS AND METHODS: A cohort of 21 patients was studied, looking for consistencies between FD and MSB results...
September 20, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28935274/a-matter-of-margins-surgical-and-pathologic-risk-factors-for-recurrence-in-extramammary-paget-s-disease
#20
Beverly Long, Adam R Schmitt, Amy L Weaver, Michaela McGree, Jamie N Bakkum-Gamez, Jerry Brewer, William A Cliby
OBJECTIVES: To determine surgical and pathologic variables associated with recurrence in extramammary Paget's disease (EMPD). METHODS: Medical records of patients seeking care for EMPD from 1/1992-9/2015 were reviewed. Follow-up was restricted to 5years following primary surgery. Recurrence-free survival (RFS) was estimated using the Kaplan-Meier method. Risk factors were evaluated for an association with recurrence and positive margins, respectively, using Cox proportional hazards regression and logistic regression...
September 18, 2017: Gynecologic Oncology
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