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https://www.readbyqxmd.com/read/28221241/hyperpolarized-helium-3-diffusion-weighted-magnetic-resonance-imaging-detects-abnormalities-of-lung-structure-in-children-with-bronchopulmonary-dysplasia
#1
Lucia Flors, John P Mugler, Alix Paget-Brown, Deborah K Froh, Eduard E de Lange, James T Patrie, Talissa A Altes
PURPOSE: The aim of the study was to determine whether hyperpolarized He diffusion-weighted magnetic resonance imaging detects abnormalities in the lungs in children with bronchopulmonary dysplasia (BPD) as compared with age-matched normal children. MATERIALS AND METHODS: All experiments were compliant with Health Insurance Portability and Accountability Act (HIPAA) and performed with Food and Drug Administration approval under an IND application. The protocol was approved by our Institutional Review Board, and written informed consent was obtained...
February 17, 2017: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/28209759/revisiting-seed-and-soil-examining-the-primary-tumor-and-cancer-cell-foraging-in-metastasis
#2
Amber E de Groot, Sounak Roy, Joel S Brown, Kenneth J Pienta, Sarah R Amend
Metastasis is the consequence of a cancer cell that disperses from the primary tumor, travels throughout the body, and invades and colonizes a distant site.  Based on Paget's 1889 hypothesis, the majority of modern metastasis research focuses on the properties of the metastatic "seed and soil," but the implications of the primary tumor "soil" have been largely neglected. The rare lethal metastatic "seed" arises as a result of the selective pressures in the primary tumor. Optimal foraging theory describes how cancer cells adopt a mobile foraging strategy to balance predation risk and resource reward...
February 16, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28196824/paget-s-disease-of-the-anus-masking-a-mixed-adenoneuroendocrine-tumour-of-the-rectum
#3
Pierson Ebrom, David Parizh, Cristina H Hajdu, Pratap Gadangi
A man aged 83 years with vague perirectal symptoms had a delayed diagnosis of Paget's disease of the anus. A lack of thorough digital rectal examination failed to diagnose a mixed adenonueroendocrine tumour of the rectum in a timely matter.
February 14, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28186860/traumatic-rib-injury-patterns-imaging-pitfalls-complications-and-treatment
#4
Brett S Talbot, Christopher P Gange, Apeksha Chaturvedi, Nina Klionsky, Susan K Hobbs, Abhishek Chaturvedi
The ribs are frequently affected by blunt or penetrating injury to the thorax. In the emergency department setting, it is vital for the interpreting radiologist to not only identify the presence of rib injuries but also alert the clinician about organ-specific injury, specific traumatic patterns, and acute rib trauma complications that require emergent attention. Rib injuries can be separated into specific morphologic fracture patterns that include stress, buckle, nondisplaced, displaced, segmental, and pathologic fractures...
February 10, 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28185722/paget-s-bone-disease-is-not-always-the-culprit
#5
Agostino Gaudio, Luca Zanoli, Carmelo Erio Fiore
No abstract text is available yet for this article.
February 6, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28183835/benign-spine-lesions-advances-in-techniques-for-minimally-invasive-percutaneous-treatment
#6
REVIEW
A Tomasian, A N Wallace, J W Jennings
Minimally invasive percutaneous imaging-guided techniques have been shown to be safe and effective for the treatment of benign tumors of the spine. Techniques available include a variety of tumor ablation technologies, including radiofrequency ablation, cryoablation, microwave ablation, alcohol ablation, and laser photocoagulation. Vertebral augmentation may be performed after ablation as part of the same procedure for fracture stabilization or prevention. Typically, the treatment goal in benign spine lesions is definitive cure...
February 9, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28178005/surgical-treatment-and-outcomes-of-patients-with-extramammary-paget-disease-a-cohort-study
#7
Sharon J Kim, Agnieszka K Thompson, Adeel S Zubair, Clark C Otley, Christopher J Arpey, Christian L Baum, Randall K Roenigk, Christine M Lohse, Jerry D Brewer
BACKGROUND: Extramammary Paget disease (EMPD) is a rare intraepithelial adenocarcinoma occurring mainly in the anogenital region. Traditional management with wide local excision has shown high recurrence rates, thus Mohs micrographic surgery (MMS) has emerged as a promising treatment option. OBJECTIVE: To compare long-term outcomes after treatment with MMS or excision for primary EMPD. METHODS AND MATERIALS: Retrospective cohort review was conducted for 207 patients with EMPD treated at Mayo Clinic in Rochester, MN, between 1961 and 2012...
February 6, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28177495/european-public-health-news
#8
Dineke Zeegers Paget
No abstract text is available yet for this article.
February 1, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28176386/long-term-randomized-trial-of-intensive-versus-symptomatic-management-in-paget-s-disease-of-bone-the-prism-ez-study
#9
Adrian Tan, Kirsteen Goodman, Allan Walker, Jemma Hudson, Graeme S MacLennan, Peter L Selby, William D Fraser, Stuart H Ralston
It has been suggested that normalization of bone turnover may improve clinical outcome in Paget's disease of bone (PDB) by preventing complications such as fractures and the development of osteoarthritis. Here we investigated the long-term effects of a treatment strategy that aimed to normalize bone turnover in PDB with that of symptomatic treatment. The study group comprised 502 subjects who were enrolled into a 3-year extension of the Paget's Disease: Randomized Trial of Intensive versus Symptomatic Management (PRISM) study...
February 8, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28166615/successful-use-of-radiotherapy-in-the-treatment-of-extramammary-paget-s-disease-in-vulvar-area
#10
Antonella Tammaro, Veronica Giulianelli, Irene Romano, Eleonora DE Vito, Francesca R Parisella, Maria Giubettini, Severino Persechino
No abstract text is available yet for this article.
April 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28165139/carboxylated-nanodiamonds-can-be-used-as-negative-reference-in-in-vitro-nanogenotoxicity-studies
#11
H Moche, V Paget, D Chevalier, E Lorge, N Claude, H A Girard, J C Arnault, S Chevillard, F Nesslany
Nanodiamonds (NDs) are promising nanomaterials for biomedical applications. However, a few studies highlighted an in vitro genotoxic activity for detonation NDs, which was not evidenced in one of our previous work quantifying γ-H2Ax after 20 and 100 nm high-pressure high-temperature ND exposures of several cell lines. To confirm these results, in the present work, we investigated the genotoxicity of the same 20 and 100 nm NDs and added intermediate-sized NDs of 50 nm. Conventional in vitro genotoxicity tests were used, i...
February 6, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28164066/giant-cell-tumor-developing-in-paget-s-disease-of-bone-a-case-report-with-review-of-literature
#12
Vivek Verma, Ajay Puri, Sanket Shah, Bharat Rekhi, Ashish Gulia
INTRODUCTION: Paget's disease of bone (PDB) is a disease of elderly characterized by disorganized bone remodeling. Development of secondary neoplasm in PDB is a known but rare phenomenon. Development of giant cell tumor in PDB (GCT-PDB) is extremely rare, and little is known about its etiopathogenesis and management. We present a case report of such a development with a review of the literature and the role of various new modalities of treatment available in the management of this rare condition...
September 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28161640/gastrodin-inhibits-osteoclastogenesis-via-down-regulating-the-nfatc1-signaling-pathway-and-stimulates-osseointegration-in%C3%A2-vitro
#13
Feng Zhou, Yi Shen, Bo Liu, Xia Chen, Lu Wan, Dan Peng
Bone is a rigid yet dynamic organ, and this dynamism is mediated by the delicate balance between osteoclastic bone resorption and osteoblastic bone formation. However, excessive activation of osteoclasts is responsible for many bone diseases such as osteoporosis, Paget disease, and tumor bone metastasis. Agents that could inhibit osteoclast formation or function are regarded as promising alternatives to treat osteoclast-related diseases. Recently, traditional Chinese medicine has attracted attention because of its multiple activities in bone metabolism...
February 2, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28157543/mutations-in-mapkbp1-cause-juvenile-or-late-onset-cilia-independent-nephronophthisis
#14
Maxence S Macia, Jan Halbritter, Marion Delous, Cecilie Bredrup, Arthur Gutter, Emilie Filhol, Anne E C Mellgren, Sabine Leh, Albane Bizet, Daniela A Braun, Heon Y Gee, Flora Silbermann, Charline Henry, Pauline Krug, Christine Bole-Feysot, Patrick Nitschké, Dominique Joly, Philippe Nicoud, André Paget, Heidi Haugland, Damien Brackmann, Nayir Ahmet, Richard Sandford, Nurcan Cengiz, Per M Knappskog, Helge Boman, Bolan Linghu, Fan Yang, Edward J Oakeley, Pierre Saint Mézard, Andreas W Sailer, Stefan Johansson, Eyvind Rødahl, Sophie Saunier, Friedhelm Hildebrandt, Alexandre Benmerah
No abstract text is available yet for this article.
February 2, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/28150330/serum-cytokeratin-19-fragment-21-1-is-a-useful-tumor-marker-for-the-assessment-of-extramammary-paget-s-disease
#15
Junji Kato, Yasuyuki Sumikawa, Tokimasa Hida, Takafumi Kamiya, Kohei Horimoto, Shiori Kamiya, Sayuri Sato, Hitomi Takahashi, Masahide Sawada, Toshiharu Yamashita
Cytokeratin 19 fragment 21-1 (CYFRA 21-1) has been used as a tumor marker for several malignancies. However, to date, no studies have assessed whether CYFRA 21-1 could be a useful marker for extramammary Paget's disease (EMPD). The present study aimed to evaluate the significance of CYFRA 21-1 as a serum tumor marker for EMPD progression. Concentrations of serum CYFRA 21-1 and carcinoembryonic antigen (CEA) in 13 cases of EMPD were measured prior to undergoing treatment at Sapporo Medical University Hospital from January 2014 to May 2016...
February 2, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28140609/imaging-concordant-benign-mri-guided-vacuum-assisted-breast-biopsy-may-not-warrant-mri-follow-up
#16
Monica L Huang, Megan Speer, Basak E Dogan, Gaiane M Rauch, Rosalind P Candelaria, Beatriz E Adrada, Kenneth R Hess, Wei T Yang
OBJECTIVE: The follow-up of breast lesions with imaging-concordant benign histopathology results on MRI-guided vacuum-assisted biopsy (VAB) is not currently standardized. We determined the false omission rate of breast MRI-guided VAB with benign histopathology (negative results) to assess whether breast MRI follow-up is needed. MATERIALS AND METHODS: The medical records of patients who underwent 9-gauge breast MRI-guided VAB during 2007-2012 were reviewed retrospectively...
January 31, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28132074/the-incidental-bone-lesion-on-computed-tomography-management-tips-for-abdominal-radiologists
#17
REVIEW
Michelle Nguyen, Christopher Beaulieu, Stefanie Weinstein, Lewis K Shin
Incidental bone lesions are commonly seen on abdominal and pelvic computed tomography (CT) examinations. These incidental bone lesions can be diagnostically challenging to the abdominal radiologist who may not be familiar with their appearance or their appropriate management. The characterization of such bone lesions as non-aggressive or aggressive based on their CT appearance involves similar principles to their morphologic evaluation on radiographs. Knowledge of the age of the patient and the presence of symptoms, mainly bone pain, can improve analysis...
January 28, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28131441/-a-rare-complication-of-paget-s-disease
#18
G Jelin, F Grados, P Fardellone, V Goëb
No abstract text is available yet for this article.
January 25, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/28128207/a-non-canonical-mismatch-repair-pathway-in-prokaryotes
#19
A Castañeda-García, A I Prieto, J Rodríguez-Beltrán, N Alonso, D Cantillon, C Costas, L Pérez-Lago, E D Zegeye, M Herranz, P Plociński, T Tonjum, D García de Viedma, M Paget, S J Waddell, A M Rojas, A J Doherty, J Blázquez
Mismatch repair (MMR) is a near ubiquitous pathway, essential for the maintenance of genome stability. Members of the MutS and MutL protein families perform key steps in mismatch correction. Despite the major importance of this repair pathway, MutS-MutL are absent in almost all Actinobacteria and many Archaea. However, these organisms exhibit rates and spectra of spontaneous mutations similar to MMR-bearing species, suggesting the existence of an alternative to the canonical MutS-MutL-based MMR. Here we report that Mycobacterium smegmatis NucS/EndoMS, a putative endonuclease with no structural homology to known MMR factors, is required for mutation avoidance and anti-recombination, hallmarks of the canonical MMR...
January 27, 2017: Nature Communications
https://www.readbyqxmd.com/read/28124023/paget-s-disease-of-the-vulva-a-review-of-89-cases
#20
Cherry O Onaiwu, Mila Pontremoli Salcedo, Suzana A Pessini, Mark F Munsell, Elizabeth E Euscher, Kellie E Reed, Kathleen M Schmeler
The purpose of this study was to retrospectively review the clinical characteristics and outcomes of a series of women with Paget's disease of the vulva. A retrospective review was performed of 89 women with Paget's disease of the vulva evaluated at a single institution between 1966 and 2010. Medical records were reviewed for demographic information, clinical data, pathologic findings, treatment modalities and outcomes. We found that the primary treatment was surgery for 74 (83.1%) patients, with positive margins noted in 70...
February 2017: Gynecologic Oncology Reports
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