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https://www.readbyqxmd.com/read/29779053/non-union-rate-of-type-ii-and-iii-odontoid-fractures-in-cppd-versus-a-control-population
#1
Aaron Wold, Jonelle Petscavage-Thomas, Eric A Walker
OBJECTIVE: The objective was to determine if there is a significant difference between rates of non-union of type II and III odontoid fractures in patients with calcium pyrophosphate dihydrate deposition (CPPD) compared with a control population. MATERIALS AND METHODS: A 10-year retrospective picture archive and communications system review was performed of 31 CPPD patients and 31 control patients. Imaging studies were reviewed for radiographic or CT evidence of osseous union and complications...
May 19, 2018: Skeletal Radiology
https://www.readbyqxmd.com/read/29760766/holistic-and-component-plant-phenotyping-using-temporal-image-sequence
#2
Sruti Das Choudhury, Srinidhi Bashyam, Yumou Qiu, Ashok Samal, Tala Awada
Background: Image-based plant phenotyping facilitates the extraction of traits noninvasively by analyzing large number of plants in a relatively short period of time. It has the potential to compute advanced phenotypes by considering the whole plant as a single object (holistic phenotypes) or as individual components, i.e., leaves and the stem (component phenotypes), to investigate the biophysical characteristics of the plants. The emergence timing, total number of leaves present at any point of time and the growth of individual leaves during vegetative stage life cycle of the maize plants are significant phenotypic expressions that best contribute to assess the plant vigor...
2018: Plant Methods
https://www.readbyqxmd.com/read/29742537/-combining-old-and-new-conventional-radiography-and-dect-for-diagnosing-cppd
#3
Joe Thomas, Kurian Ninan
No abstract text is available yet for this article.
May 4, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29730681/clinical-and-ultrasound-findings-in-patients-with-calcium-pyrophosphate-dihydrate-deposition-disease
#4
Paulina Vele, Siao-Pin Simon, Laura Damian, Ioana Felea, Laura Muntean, Ileana Filipescu, Simona Rednic
AIM: To evaluate the presence and distribution of calcium pyrophosphate (CPP) deposits in joints commonly affected by CPP deposition (CPPD) disease (acromio-clavicular, gleno-humeral, wrists, hips, knees, ankles, and symphysis pubis joints) using ultrasound (US). MATERIAL AND METHODS: Thirty consecutive patients fulfilling McCarty diagnostic criteria for CPPD were consecutively enrolled in the study. The data registered using the US included the affected joints, the calcification site, and the pattern of calcification (thin hyperechoic bands, parallel to the surface of the hyaline cartilage, hyperechoic spots, and hyperechoic nodular or oval deposits)...
May 2, 2018: Medical Ultrasonography
https://www.readbyqxmd.com/read/29688536/inhibition-of-nucleotide-pyrophosphatase-phosphodiesterase-1-implications-for-developing-a-calcium-pyrophosphate-deposition-disease-modifying-drug
#5
Ortal Danino, Shuli Svetitsky, Sarah Kenigsberg, Asaf Levin, Shani Journo, Aviram Gold, Michael Drexler, Nimrod Snir, Ori Elkayam, Bilha Fischer, Uri Arad
Objectives: Calcium pyrophosphate deposition (CPPD) is associated with osteoarthritis and is the cause of a common inflammatory articular disease. Ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (eNPP1) is the major ecto-pyrophosphatase in chondrocytes and cartilage-derived matrix vesicles (MVs). Thus, eNPP1 is a principle contributor to extracellular pyrophosphate levels and a potential target for interventions aimed at preventing CPPD. Recently, we synthesized and described a novel eNPP1-specific inhibitor, SK4A, and we set out to evaluate whether this inhibitor attenuates nucleotide pyrophosphatase activity in human OA cartilage...
April 24, 2018: Rheumatology
https://www.readbyqxmd.com/read/29675606/therapy-for-cppd-options-and-evidence
#6
REVIEW
Mariano Andrés, Francisca Sivera, Eliseo Pascual
PURPOSE OF REVIEW: Current evidence and accumulated experience for the management of calcium pyrophosphate deposition disease (CPPD) are presented. RECENT FINDINGS: Contrary to other rheumatic inflammatory conditions that account for high interest and growing research, advances in treating CPPD are still very limited and mostly derive from those achieved in gout. Once formed, calcium pyrophosphate crystals cannot be dissolved; therefore, management relies on the control of crystal-derived inflammation...
April 19, 2018: Current Rheumatology Reports
https://www.readbyqxmd.com/read/29666904/pseudogout-among-patients-fulfilling-a-billing-code-algorithm-for-calcium-pyrophosphate-deposition-disease
#7
Sara K Tedeschi, Daniel H Solomon, Katherine P Liao
To test the performance of a billing claims-based calcium pyrophosphate deposition disease (CPPD) algorithm for identifying pseudogout. We applied a published CPPD algorithm at an academic institution and randomly selected 100 patients for electronic medical record review for 3 phenotypes: (1) definite/probable CPPD, (2) definite/probable pseudogout; (3) definite pseudogout. Clinical data were recorded and positive predictive value (PPV) (95% CI) for each phenotype was calculated. We then modified the published algorithm to require ≥ 1 of 4 relevant terms ("pseudogout", "calcium pyrophosphate crystals", "CPPD", or "chondrocalcinosis") through automated text searching in clinical notes, and re-calculated PPVs...
April 17, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29657876/magnesium-disorders-can-cause-calcium-pyrophosphate-deposition-disease-a-case-report-and-literature-review
#8
REVIEW
Akanksha Joshi, Chokkalingam Siva
Calcium pyrophosphate deposition (CPPD) disease, also known as pseudogout, is one of the most common forms of inflammatory arthritis. A variety of comorbidities and metabolic conditions have been recognized to predispose to CPPD. We describe here a patient with chronic CPP arthritis due to hypomagnesemia, which is one of the metabolic etiologies associated with CPPD, especially in younger patients. We also performed a literature search and reviewed all reported cases of CPPD disease associated with hypomagnesemia...
March 2018: European Journal of Rheumatology
https://www.readbyqxmd.com/read/29622016/detection-of-calcium-pyrophosphate-dihydrate-crystals-in-knee-meniscus-by-dual-energy-computed-tomography
#9
Hidenori Tanikawa, Ryo Ogawa, Kazunari Okuma, Kengo Harato, Yasuo Niki, Shu Kobayashi, Takeo Nagura
BACKGROUND: Calcium pyrophosphate dihydrate (CPPD) crystals are commonly observed in osteoarthritic joints. The aim of our study was to investigate the efficacy of a dual-energy computed tomography (DECT) for detecting CPPD crystals in knee meniscus. METHODS: Twenty-six patients undergoing primary total knee arthroplasty were included in the study. Radiographs of knee joint and synovial fluid specimens were analyzed for the presence of CPPD crystals. Meniscus extracted during surgery was scanned using DECT...
April 5, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29609209/unmet-needs-and-the-path-forward-in-joint-disease-associated-with-calcium-pyrophosphate-crystal-deposition
#10
REVIEW
Abhishek Abhishek, Tuhina Neogi, Hyon Choi, Michael Doherty, Ann K Rosenthal, Robert Terkeltaub
Calcium pyrophosphate (CPP) crystal deposition (CPPD) is prevalent, and can be associated with synovitis and joint damage. The older-aged population predominantly affected by CPPD is growing rapidly. Since shortfalls exist in many aspects of CPPD, we conducted an anonymous survey of CPPD unmet needs, prioritized by experts from the Gout, Hyperuricemia and Crystal-Associated Disease Network (G-CAN). We provide our perspectives on the survey results, and propose several CPPD basic and clinical translational research pathways...
April 2, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29535120/identification-of-calcium-pyrophosphate-deposition-disease-cppd-by-ultrasound-reliability-of-the-omeract-definitions-in-an-extended-set-of-joints-an-international-multiobserver-study-by-the-omeract-calcium-pyrophosphate-deposition-disease-ultrasound-subtask
#11
Georgios Filippou, Carlo Alberto Scirè, Antonella Adinolfi, Nemanja S Damjanov, Greta Carrara, George A W Bruyn, Tomas Cazenave, Maria Antonietta D'Agostino, Andrea Delle Sedie, Valentina Di Sabatino, Mario Enrique Diaz Cortes, Emilio Filippucci, Frederique Gandjbakhch, Marwin Gutierrez, Daryl K Maccarter, Mihaela Micu, Ingrid Möller Parera, Gaël Mouterde, Mohamed Atia Mortada, Esperanza Naredo, Carlos Pineda, Francesco Porta, Anthony M Reginato, Iulia Satulu, Wolfgang A Schmidt, Teodora Serban, Lene Terslev, Violeta Vlad, Florentin Ananu Vreju, Pascal Zufferey, Panagiotis Bozios, Carmela Toscano, Valentina Picerno, Annamaria Iagnocco
OBJECTIVES: To assess the reliability of the OMERACT ultrasound (US) definitions for the identification of calcium pyrophosphate deposition disease (CPPD) at the metacarpal-phalangeal, triangular fibrocartilage of the wrist (TFC), acromioclavicular (AC) and hip joints. METHODS: A web-based exercise and subsequent patient-based exercise were carried out. A panel of 30 OMERACT members, participated at the web-based exercise by evaluating twice a set of US images for the presence/absence of CPPD...
March 13, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29399706/differential-diagnostic-perspectives-provided-by-en-face-microscopic-examination-of-articular-surface-defects
#12
Bruce M Rothschild
Surface defects have a central position in diagnosis of articular pathology. Recognizing the limitations of standard radiologic techniques and those imposed by positioning and averaging artifacts on CT evaluation, direct visualization of surface defects was pursued to identify disease characteristics that would facilitate interpretation of radiologic findings. Epi-illumination surface microscopy was utilized to examine macroscopically recognized articular surface defects in individuals in the Hamann-Todd, Terry, and Huntington human skeletal collections with previously verified diagnoses of rheumatoid arthritis, spondyloarthropathy, juvenile inflammatory arthritis (JIA), calcium pyrophosphate deposition disease (CPPD), gout, metastatic cancer, multiple myeloma, septic arthritis, tuberculosis, fungal arthritis, histiocytosis and sickle cell anemia (Rothschild and Rothschild Clin Infect Dis 20(5):1402-1408, 1995; Rothschild et al...
March 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/28965942/comparison-of-ultrasonography-and-radiography-of-the-wrist-for-diagnosis-of-calcium-pyrophosphate-deposition
#13
Marine Forien, Alice Combier, Anaïs Gardette, Elisabeth Palazzo, Philippe Dieudé, Sébastien Ottaviani
OBJECTIVE: Ultrasound (US) seems a useful tool for diagnosis of calcium pyrophosphate (CPP) deposition (CPPD). We aimed to compare the performance of US and conventional radiography of the wrist for diagnosis of CPPD. METHODS: Patients with CPP crystals identified in synovial fluid (SF) (knee, hip, shoulder, ankle or wrist) were consecutively included and compared to patients without CPP crystals in synovial fluid considered as controls. As recommended, we used the term chondrocalcinosis (CC) to assess imaging features suggesting CPPD...
September 28, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28774457/conventional-radiology-in-crystal-arthritis-gout-calcium-pyrophosphate-deposition-and-basic-calcium-phosphate-crystals
#14
REVIEW
Thibaut Jacques, Paul Michelin, Sammy Badr, Michelangelo Nasuto, Guillaume Lefebvre, Neal Larkman, Anne Cotten
This article reviews the main radiographic features of crystal deposition diseases. Gout is linked to monosodium urate crystals. Classic radiographic features include subcutaneous tophi, large and well-circumscribed paraarticular bone erosions, and exuberant bone hyperostosis. Calcium pyrophosphate deposition (CPPD) can involve numerous structures, such as hyaline cartilages, fibrocartilages, or tendons. CPPD arthropathy involves joints usually spared by osteoarthritis. Basic calcium phosphate deposits are periarticular or intraarticular...
September 2017: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/28678964/arthritic-lesions-and-congenital-fusion-in-foot-bones-of-panochthus-sp-xenarthra-cingulata
#15
Fernando Henrique DE S Barbosa, Kleberson DE O Porpino, Bruce M Rothschild, Uiara G Cabral, Lilian P Bergqvist
A set of lesions are re-described and new pathological findings in foot bones of Panochthus sp. (Xenarthra, Cingulata) are presented. The material reexamined in fact presents enthesiophytes instead of osteoartrithis, as previously interpreted. Furthermore, Calcium Pyrophosphate Deposition Disease (CPPD) was observed, a lesion absent in previous report. CPPD also was found in another set of foot bones and it was associated with a congenital fusion of two sesamoids. The material studied were collected in two natural tank deposits, one in Paraíba (material reexamined) and other in Rio Grande do Norte (new pathological findings) State...
June 29, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28567149/comparison-of-meniscal-cell-mediated-and-chondrocyte-mediated-calcification
#16
Alex J Kiraly, Andrea Roberts, Michael Cox, David Mauerhan, Edward Hanley, Yubo Sun
BACKGROUND: Chondrocytes have been traditionally thought to be responsible for calcium crystal deposits within osteoarthritic knees. Increasing recent experimental evidence suggests that menisci may also play a role. However, the calcifying potential of chondrocytes and meniscal cells derived from same OA patients, and the genes associated with meniscal calcification have never been fully examined. OBJECTIVE: Examine and compare the calcifying potential of articular chondrocytes and meniscal cells derived from same OA patients and identify the calcium crystal type(s) and selected gene expression in OA menisci...
2017: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/28524751/pseudogout-of-the-cervical-and-thoracic-spine-mimicking-infection-after-lumbar-fusion-case-report
#17
Kelly J Bridges, Carli L Bullis, Ajay Wanchu, Khoi D Than
Pseudogout is a form of acute calcium pyrophosphate deposition (CPPD) disease that typically afflicts the elderly. CPPD commonly involves larger joints, such as the knees, wrists, shoulders, and hips, and has been known to involve the spine. The authors report the case of a 66-year-old woman with a recent history of lumbar laminectomy and fusion who presented 5 weeks postprocedure with a clinical and radiographic picture consistent with multilevel skip lesions involving the cervical and thoracic spine, thoracic discitis, and epidural abscess...
August 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28413222/calcium-pyrophosphate-deposition-disease-in-the-ankle-joint-a-case-report
#18
Brynne E Stainsby, Nadine Ellul, Angelica Dimopoulos, Caitlin Lubberdink, Vanessa Salerno, Michelle Solomon
OBJECTIVE: To detail the presentation of calcium pyrophosphate deposition disease (CPPD) in the ankle joint. The aim of this case report is to inform health-care practitioners about the presentation of this condition in an uncommon location and discuss the diagnosis, potential treatment, and management strategies for a patient with CPPD. CLINICAL FEATURES: A 36-year-old male patient presented to a chiropractic clinic with an acute, painful, and swollen ankle, which was later diagnosed by plain film radiograph as CPPD...
March 2017: Journal of the Canadian Chiropractic Association
https://www.readbyqxmd.com/read/28389931/physicochemical-characterization-of-mineral-deposits-in-human-ligamenta-flava
#19
Sylwia Orzechowska, Andrzej Wróbel, Marcin Kozieł, Wiesław Łasocha, Eugeniusz Rokita
The aim of our study was the detailed characterization of calcium deposits in ligamenta flava. The use of microcomputed tomography allowed extending the routine medical investigations to characterize mineral grains in the microscopic scale. A possible connection between spinal stenosis and ligament mineralization was investigated. The studies were carried out on 24 surgically removed ligamentum flavum samples divided into control and stenosis groups. Physicochemical characterization of the inorganic material was performed using X-ray fluorescence, X-ray diffraction, and Fourier transform infrared spectroscopy...
April 7, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/28339356/diagnostic-accuracy-of-musculoskeletal-ultrasound-and-conventional-radiography-in-the-assessment-of-the-wrist-triangular-fibrocartilage-complex-in-patients-with-definite-diagnosis-of-calcium-pyrophosphate-dihydrate-deposition-disease
#20
COMPARATIVE STUDY
Andrea Di Matteo, Emilio Filippucci, Fausto Salaffi, Marina Carotti, Davide Carboni, Eleonora Di Donato, Walter Grassi
OBJECTIVES: To compare the diagnostic accuracy of musculoskeletal ultrasound (MSUS) and x-ray in evaluating wrist triangular fibrocartilage complex (TFCC) in patients with calcium pyrophosphate dihydrate deposition disease (CPPD) and to investigate the agreement between the extent of the calcium pyrophosphate dihydrate (CPP) crystal deposits assessed by MSUS and the radiographic findings. METHODS: We enrolled 84 patients: 36 patients with "definite" CPPD and 48 controls...
July 2017: Clinical and Experimental Rheumatology
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