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Birth induction

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https://www.readbyqxmd.com/read/27905861/sodium-bisulfite-pyrosequencing-revealed-that-developmental-exposure-to-environmental-contaminant-mixtures-does-not-affect-dna-methylation-of-dna-repeats-in-sprague-dawley-rats
#1
Daniel Desaulniers, Cathy Cummings-Lorbetskie, Nanqin Li, Gong-Hua Xiao, Leonora Marro, Nasrin Khan, Karen Leingartner
Hypomethylation of DNA repeats has been linked to diseases and cancer predisposition. Human studies suggest that higher blood concentrations of environmental contaminants (EC) correlate with levels of hypomethylation of DNA repeats in blood. The objective of this study was to examine the effect of in utero and/or lactational exposure to EC on the methylation of DNA repeats (LINE-1 and identifier element) in Sprague-Dawley rat pups at birth, at postnatal day (PND) 21, and in adulthood (PND78-86). From gestation day 0 to PND20, dams were exposed to a mixture "M" of polychlorinated biphenyls (PCB), pesticides, and methylmercury (MeHg), at 0...
December 1, 2016: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/27904626/respect-for-woman-s-decision-making-in-spontaneous-birth-a-thematic-synthesis-study
#2
Firoozeh MirzaeeRabor, Fattaneh Mirzaee, Khadigeh MirzaiiNajmabadi, Ali Taghipour
BACKGROUND: Participation of woman in decision-making processes is one of the key indicators of an appropriate relationship between a woman and the health care professionals. This study aimed to recognize the factors facilitating respect for woman's decision-making in spontaneous birth. MATERIALS AND METHODS: This paper employed a meta-synthesis on articles published in four biomedical databases including MEDLINE, Web of Science, CINAHL, and Cochrane Library. All qualitative studies published after 1990 and directly or indirectly discussing the women's and the health care professional's attitudes toward respect for woman's decision-making in spontaneous birth were searched...
September 2016: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/27886948/variation-in-hospital-intrapartum-practices-and-association-with-cesarean-rate
#3
Lisbet S Lundsberg, Jessica L Illuzzi, Aileen M Gariepy, Sangini S Sheth, Christian M Pettker, Henry C Lee, Heather S Lipkind, Xiao Xu
OBJECTIVE: To examine hospital variation in intrapartum care and its relationship with cesarean rates. DESIGN: Cross-sectional survey. SETTING: Connecticut and Massachusetts hospitals providing obstetric services. PARTICIPANTS: Nurse managers or other clinical staff knowledgeable about intrapartum care. METHODS: We assessed labor and birth unit capacity and staffing, fetal monitoring, labor management, intrapartum interventions, newborn care, quality assurance, and performance review practices...
November 22, 2016: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/27883236/long-term-reduction-in-food-allergy-susceptibility-in-mice-by-combining-breastfeeding-induced-tolerance-and-tgf-%C3%AE-enriched-formula-after-weaning
#4
Akila Rekima, Patricia Macchiaverni, Mathilde Turfkruyer, Sebastien Holvoet, Lénaïck Dupuis, Nour Baiz, Isabella Annesi-Maesano, Annick Mercenier, Sophie Nutten, Valérie Verhasselt
BACKGROUND: Oral tolerance induction in early life is a promising approach for food allergy prevention. Its success requires the identification of factors necessary for its persistence. OBJECTIVES: We aimed to assess in mice duration of allergy prevention by breastfeeding-induced oral tolerance and whether oral TGF-β supplementation after weaning would prolong it. METHODS: We quantified ovalbumin (OVA) and OVA specific immunoglobulins levels by ELISA in milk from the EDEN birth cohort...
November 24, 2016: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27880803/wdr68-mediates-dorsal-and-ventral-patterning-events-for-craniofacial-development
#5
Estibaliz Alvarado, Mina Yousefelahiyeh, Greg Alvarado, Robin Shang, Taryn Whitman, Andrew Martinez, Yang Yu, Annie Pham, Anish Bhandari, Bingyan Wang, Robert M Nissen
Birth defects are among the leading causes of infant mortality and contribute substantially to illness and long-term disability. Defects in Bone Morphogenetic Protein (BMP) signaling are associated with cleft lip/palate. Many craniofacial syndromes are caused by defects in signaling pathways that pattern the cranial neural crest cells (CNCCs) along the dorsal-ventral axis. For example, auriculocondylar syndrome is caused by impaired Endothelin-1 (Edn1) signaling, and Alagille syndrome is caused by defects in Jagged-Notch signaling...
2016: PloS One
https://www.readbyqxmd.com/read/27862907/motivations-for-entering-the-doula-profession-perspectives-from-women-of-color
#6
Rachel R Hardeman, Katy B Kozhimannil
INTRODUCTION: The imperative to diversify the health care workforce is evident: increased diversity contributes to the overall health of the nation. Given persistent racial and ethnic disparities in birth outcomes, workforce diversity is particularly urgent in the context of clinical and supportive care during pregnancy and childbirth. The goal of this analysis was to characterize the intentions and motivations of racially and ethnically diverse women who chose to become doulas (maternal support professionals) and to describe their early doula careers, including the experiences that sustain their work...
November 14, 2016: Journal of Midwifery & Women's Health
https://www.readbyqxmd.com/read/27861646/effect-of-geranylgeranylacetone-on-the-protection-of-retinal-ganglion-cells-in-a-mouse-model-of-normal-tension-glaucoma
#7
Zhenyu Dong, Yasuhiro Shinmei, Yoko Dong, Saori Inafuku, Junichi Fukuhara, Ryo Ando, Nobuyoshi Kitaichi, Atsuhiro Kanda, Kohichi Tanaka, Kousuke Noda, Takayuki Harada, Shinki Chin, Susumu Ishida
Glaucoma is characterized by axonal degeneration of retinal ganglion cells (RGCs) and apoptotic death of their cell bodies, and lowering intraocular pressure is associated with an attenuation of progressive optic nerve damage. Nevertheless, intraocular pressure (IOP) reduction alone was not enough to inhibit the progression of disease, which suggests the contribution of other factors to the glaucoma pathogenesis. In this study, we investigated the cytoprotective effect of geranylgeranylacetone (GGA) on RGCs degeneration using a normal tension glaucoma (NTG) mouse model, which lacks glutamate/aspartate transporter (GLAST) and demonstrates spontaneous RGC and optic nerve degeneration without elevated intraocular pressure (IOP)...
October 2016: Heliyon
https://www.readbyqxmd.com/read/27855085/comparison-of-acupuncture-pretreatment-followed-by-letrozole-versus-letrozole-alone-on-live-birth-in-anovulatory-infertile-women-with-polycystic-ovary-syndrome-a-study-protocol-for-a-randomised-controlled-trial
#8
Juan Li, Ernest Hung Yu Ng, Elisabet Stener-Victorin, Zhenxing Hu, Wanting Wu, Maohua Lai, Taixiang Wu, Hongxia Ma
INTRODUCTION: The high prevalence of insulin resistance in women with polycystic ovary syndrome (PCOS) is considered to be one of the major pathophysiological changes in PCOS that leads to anovulatory infertility. We hypothesise that electroacupuncture pretreatment improves insulin sensitivity and leads to a higher ovulation rate and greater chances of live birth after the induction of ovulation. The effect of electroacupuncture pretreatment followed by ovulation induction in women with anovulatory PCOS has not been investigated before, and we present here a randomised controlled trial to test this hypothesis by comparing electroacupuncture pretreatment followed by letrozole versus letrozole alone in anovulatory women with PCOS...
October 7, 2016: BMJ Open
https://www.readbyqxmd.com/read/27844497/is-a-cause-of-postpartum-hemorrhage-of-using-of-tocolytic-agents-in-preterm-delivery
#9
Soo Ran Choi, NaeRi Yoon, Sung Ook Hwang
OBJECTIVE: Tocolytic agents are used to inhibit uterine contraction in preterm. The authors undertook this study to determine whether the using of tocolytics agents before delivery is associated with increase postpartum hemorrhage in preterm delivered women. METHOD: 296 singleton pregnancies delivered preterm from 24 + 1 to 37 + 0 weeks gestation were retrospectively reviewed. Hemoglobin (HB) and hematocrit (HCT) levels were checked before and after delivery to access postpartum blood loss...
November 15, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27828666/maternal-protein-restriction-during-lactation-modulated-the-expression-and-activity-of-rat-offspring-hepatic-cyp1a1-cyp1a2-cyp2b1-cyp2b2-and-cyp2e1-during-development
#10
N Meireles Da Costa, S B C Visoni, I L Dos Santos, T C Barja-Fidalgo, L F Ribeiro-Pinto
Early nutrition plays a long-term role in the predisposition to chronic diseases and influences the metabolism of several drugs. This may happen through cytochromes P450 (CYPs) regulation, which are the main enzymes responsible for the metabolism of xenobiotics. Here, we analyzed the effects of maternal protein restriction (MPR) on the expression and activity of hepatic offspring's CYPs during 90 days after birth, using Wistar rats as a mammal model. Hepatic CYP1A1, CYP1A2, CYP2B1, CYP2B2 and CYP2E1 mRNA and protein expression, and associated catalytic activities (ECOD, EROD, MROD, BROD, PROD and PNPH) were evaluated in 15-, 30-, 60-, and 90-day-old offspring from dams fed with either a 0% protein (MPR groups) or a standard diet (C groups) during the 10 first days of lactation...
2016: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/27824748/oregon-s-hard-stop-policy-limiting-elective-early-term-deliveries-association-with-obstetric-procedure-use-and-health-outcomes
#11
Jonathan M Snowden, Ifeoma Muoto, Blair G Darney, Brian Quigley, Mark W Tomlinson, Duncan Neilson, Steven A Friedman, Joanne Rogovoy, Aaron B Caughey
OBJECTIVE: To evaluate the association of Oregon's hard-stop policy limiting early elective deliveries (before 39 weeks of gestation) and the rate of elective early-term inductions and cesarean deliveries and associated maternal-neonatal outcomes. METHODS: This was a population-based retrospective cohort study of Oregon births between 2008 and 2013 using vital statistics data and multivariable logistic regression models. Our exposure was the Oregon hard-stop policy, defined as the time periods prepolicy (2008-2010) and postpolicy (2012-2013)...
December 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27824403/delivery-outcomes-after-term-induction-of-labor-in-small-for-gestational-age-fetuses
#12
Janine S Rhoades, Roxane M Rampersad, Methodius G Tuuli, George A Macones, Alison G Cahill, Molly J Stout
Objective The objective of this study was to estimate the delivery outcomes after induction of labor (IOL) at term in patients with small-for-gestational age (SGA) fetuses. Study Design A secondary analysis of a prospective cohort study of all term, singleton deliveries from 2010 to 2014. Patients who underwent an IOL for any indication were included. Delivery outcomes were compared between patients with and without SGA fetuses (defined as birth weight < 10th percentile for gestational age). Analysis was stratified by parity...
November 4, 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/27819333/novel-toll-like-receptor-4-antagonist-naloxone-protects-mice-from-inflammation-induced-preterm-birth
#13
Peck Yin Chin, Camilla L Dorian, Mark R Hutchinson, David M Olson, Kenner C Rice, Lachlan M Moldenhauer, Sarah A Robertson
Toll-like receptor 4 (TLR4) activation by bacterial infection, or by sterile inflammatory insult is a primary trigger of spontaneous preterm birth. Here we utilize mouse models to investigate the efficacy of a novel small molecule TLR4 antagonist, (+)-naloxone, the non-opioid isomer of the opioid receptor antagonist (-)-naloxone, in infection-associated preterm birth. Treatment with (+)-naloxone prevented preterm delivery and alleviated fetal demise in utero elicited by i.p. LPS administration in late gestation...
November 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27818419/relationship-between-hospital-policies-for-labor-induction-and-cesarean-delivery-and-perinatal-care-quality-among-rural-u-s-hospitals
#14
Katy B Kozhimannil, Peiyin Hung, Michelle M Casey, Carrie Henning-Smith, Shailendra Prasad, Ira S Moscovice
Many hospitals are adopting quality improvement strategies in obstetrics. This study characterized rural U.S. hospitals based on their hospital staffing and clinical management policies for labor induction and cesarean delivery, and assessed the relationship between policies and performance on maternity care quality. We surveyed all 306 rural maternity hospitals in nine states and used data from the Healthcare Cost and Utilization Project Statewide Inpatient Database hospital discharge database. We found staffing policies were more prevalent at lower-volume hospitals (92% vs...
2016: Journal of Health Care for the Poor and Underserved
https://www.readbyqxmd.com/read/27813240/immediate-delivery-or-expectant-management-in-gestational-diabetes-at-term-the-ginexmal-randomised-controlled-trial
#15
S Alberico, A Erenbourg, M Hod, Y Yogev, E Hadar, F Neri, L Ronfani, G Maso
OBJECTIVE: To evaluate maternal and perinatal outcomes after induction of labour versus expectant management in pregnant women with gestational diabetes at term. DESIGN: Multicentre open-label randomised controlled trial. SETTING: Eight teaching hospitals in Italy, Slovenia, and Israel. SAMPLE: Singleton pregnancy, diagnosed with gestational diabetes by the International Association of Diabetes and Pregnancy Study Groups criteria (IADPSGC), between 38(+0) and 39(+0) weeks of gestation, without other maternal or fetal conditions...
November 4, 2016: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27806661/intrapartum-intervention-rates-and-perinatal-outcomes-following-induction-of-labour-after-41%C3%A2-%C3%A2-0-weeks-compared-to-expectant-management
#16
Elaine Yuzhen Teo, Sailesh Kumar
OBJECTIVE: There is limited evidence regarding the incidence of intrapartum fetal compromise in women who are induced compared to those managed expectantly. The aim of this study was to investigate intrapartum and perinatal outcomes in women who were induced at >41 + 0 weeks compared to an expectantly managed cohort. METHODS: This was a retrospective cohort study of singleton, non anomalous pregnancies delivering between 41 + 0-43 + 0 weeks at the Mater Mothers' Hospital, Brisbane...
November 2, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27803267/what-s-the-rush-tort-laws-and-elective-early-term-induction-of-labor
#17
Louise Marie Roth
Tort laws aim to deter risky medical practices and increase accountability for harm. This research examines their effects on deterrence of a high-risk obstetric practice in the United States: elective early-term (37-38 weeks gestation) induction of labor. Using birth certificate data from the Natality Detail Files and state-level data from publicly available sources, this study analyzes the effects of tort laws on labor induction with multilevel models (MLM) of 665,491 early-term births nested in states. Results reveal that caps on damages are associated with significantly higher odds of early-term induction and Proportionate Liability (PL) is associated with significantly lower odds compared to Joint and Several Liability (JSL)...
November 1, 2016: Journal of Health and Social Behavior
https://www.readbyqxmd.com/read/27801979/preaxial-polydactyly-following-early-gestational-exposure-to-the-smoothened-agonist-sag-in-c57bl-6j-mice
#18
Eric W Fish, Scott E Parnell, Kathleen K Sulik, Lorinda K Baker, Laura B Murdaugh, David Lamson, Kevin P Williams
BACKGROUND: While pharmacological activation of the Hedgehog (HH) signaling pathway may have therapeutic benefits for developmental and adult diseases, its teratogenic potential is of concern. The membrane molecule Smoothened (SMO) transduces HH signaling and can be acutely modulated by antagonists and agonists. The objective of the current experiments was to determine how maternal treatment with the Smo agonist, SAG, affects the developing limb. METHODS: Pregnant C57BL/6J mice received a single injection of SAG (15, 17, or 20 mg/kg, i...
November 1, 2016: Birth Defects Research. Part A, Clinical and Molecular Teratology
https://www.readbyqxmd.com/read/27799944/repair-injured-heart-by-regulating-cardiac-regenerative-signals
#19
REVIEW
Wen-Feng Cai, Guan-Sheng Liu, Lei Wang, Christian Paul, Zhi-Li Wen, Yigang Wang
Cardiac regeneration is a homeostatic cardiogenic process by which the sections of malfunctioning adult cardiovascular tissues are repaired and renewed employing a combination of both cardiomyogenesis and angiogenesis. Unfortunately, while high-quality regeneration can be performed in amphibians and zebrafish hearts, mammalian hearts do not respond in kind. Indeed, a long-term loss of proliferative capacity in mammalian adult cardiomyocytes in combination with dysregulated induction of tissue fibrosis impairs mammalian endogenous heart regenerative capacity, leading to deleterious cardiac remodeling at the end stage of heart failure...
2016: Stem Cells International
https://www.readbyqxmd.com/read/27788533/24-7-presence-of-medical-staff-in-the-labor-ward-no-day-night-differences-in-perinatal-and-maternal-outcomes
#20
Sara Tavares, João Cavaco-Gomes, Marina Moucho, Milton Severo, Mário Mateus, Carla Ramalho, Gerard H A Visser, Nuno Montenegro
Objective The objective of this study was to assess possible day-night differences in perinatal and maternal labor outcomes in a hospital setting with no day-night differences in the presence of experienced medical staff. Design This was a retrospective study conducted over 5 years between 2008 and 2012. Setting This study was set at the obstetric delivery unit in a tertiary hospital. Population A total of 9,143 singleton deliveries were assessed after 34 weeks of gestation and after exclusion of major congenital malformations, inductions of labor, and elective cesarean sections...
October 27, 2016: American Journal of Perinatology
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