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https://www.readbyqxmd.com/read/28934084/outcome-of-icsi-with-motile-testicular-spermatozoa-obtained-through-microscopically-assisted-testicular-sperm-extraction-in-relation-to-the-ovarian-response
#1
E Erdem, M Karacan, A Usta, A Arvas, Z Cebi, T Camlibel
INTRODUCTION: To determine the relationship between AFC, basal FSH level, woman's age, the number of oocytes retrieved and the outcome of ICSI with testicular spermatozoa obtained with microscopically assisted testicular sperm extraction. MATERIAL AND METHODS: In this retrospective cohort study, a total of 340 couples who underwent ICSI treatment with testicular sperm were enrolled. Women aged?40years and the first cycles of couples were included. ICSI was performed with motile testicular spermatozoa obtained from 89 men with obstructive azoospermia and 251 men with nonobstructive azoospermia...
May 2017: Journal of gynecology obstetrics and human reproduction
https://www.readbyqxmd.com/read/28931940/brd4-regulates-adiponectin-gene-induction-by-recruiting-the-p-tefb-complex-to-the-transcribed-region-of-the-gene
#2
Naoko Sakurai, Yuko Inamochi, Takuya Inoue, Natsuyo Hariya, Musashi Kawamura, Masami Yamada, Anup Dey, Akira Nishiyama, Takeo Kubota, Keiko Ozato, Toshinao Goda, Kazuki Mochizuki
We previously reported that induction of the adipocyte-specific gene adiponectin (Adipoq) during 3T3-L1 adipocyte differentiation is closely associated with epigenetic memory histone H3 acetylation on the transcribed region of the gene. We used 3T3-L1 adipocytes and Brd4 heterozygous mice to investigate whether the induction of Adipoq during adipocyte differentiation is regulated by histone acetylation and the binding protein bromodomain containing 4 (BRD4) on the transcribed region. Depletion of BRD4 by shRNA and inhibition by (+)-JQ1, an inhibitor of BET family proteins including BRD4, reduced Adipoq expression and lipid droplet accumulation in 3T3-L1 adipocytes...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28928416/zika-virus-infection-confers-protection-against-west-nile-virus-challenge-in-mice
#3
Ángela Vázquez-Calvo, Ana-Belén Blázquez, Estela Escribano-Romero, Teresa Merino-Ramos, Juan-Carlos Saiz, Miguel A Martín-Acebes, Nereida Jiménez de Oya
Flaviviruses are RNA viruses that constitute a worrisome threat to global human and animal health. Zika virus (ZIKV), which was initially reported to cause a mild disease, recently spread in the Americas, infecting millions of people. During this recent epidemic, ZIKV infection has been linked to serious neurological diseases and birth defects, specifically Guillain-Barrè syndrome (GBS) and microcephaly. Because information about ZIKV immunity remains scarce, we assessed the humoral response of immunocompetent mice to infection with three viral strains of diverse geographical origin (Africa, Asia and America)...
September 20, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28921607/in-labor-or-in-limbo-the-experiences-of-women-undergoing-induction-of-labor-in-hospital-findings-of-a-qualitative-study
#4
Annabel Jay, Hilary Thomas, Fiona Brooks
BACKGROUND: Induction of labor currently accounts for around 25% of all births in high-resource countries, yet despite much research into medical aspects, little is known about how women experience this process. This study aimed to explore in depth the induction experience of primiparous women. METHODS: A qualitative study was undertaken, using a sample of 21 first-time mothers from a maternity unit in the south of England. Semi-structured interviews were conducted in women's homes between 3 and 6 weeks postnatally...
September 17, 2017: Birth
https://www.readbyqxmd.com/read/28917126/effects-of-a-single-administration-of-different-gonadotropins-on-day-7%C3%A2-post-insemination-on-pregnancy-outcomes-of-rabbit-does
#5
N M Hashem, Z R Aboul-Ezz
This study aimed to investigate the effects of a single administration of one of three different gonadotropins on Day 7 post-insemination on ovarian activity, progesterone (P4) concentration and pregnancy outcomes of rabbit does. Multiparous, non-lactating, V-line does were artificially inseminated after synchronization and ovulation induction with equine chorionic gonadotropin (eCG; 25 IU im) and gonadotropin releasing hormone (GnRH; 0.8  μg buserelin im) 48 h later. On Day 7 post-inseminarion, does were randomly allocated into four groups (n = 40/group)...
September 7, 2017: Theriogenology
https://www.readbyqxmd.com/read/28916946/association-between-placental-polycyclic-aromatic-hydrocarbons-pahs-oxidative-stress-and-preterm-delivery-a-case-control-study
#6
Priyanka Agarwal, Laxmi Singh, Madhu Anand, Ajay Taneja
Polycyclic aromatic hydrocarbons are known to disturb the antioxidant defense system, which may indirectly contribute to induction of early pregnancy in women. Therefore, the present investigation was designed to offer preliminary information about exposure to PAHs by estimating their placental levels and its association with oxidative stress as well as with preterm birth. Placenta tissue samples were drawn after delivery from 84 healthy pregnant women, recruited at a local nursing home of Agra, India, and levels of PAHs were quantified by gas chromatograph equipped with flame ionization detector...
September 15, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28915528/-antenatal-steroid-therapy-in-threatened-premature-birth-state-of-the-art
#7
Dimitra Stavropoulou, Roland Hentschel
The aim of this work is to provide an overview of the recommendations in the current literature for the induction of lung maturation therapy. In particular, special attention is focused on specific situations, such as chorioamnionitis, intrauterine growth retardation and preeclampsia, which often lead to premature birth. Additionally, some aspects of antenatal steroid therapy, despite its widespread use, still require clarification. Among them is the repetitive administration of steroid therapy. On the basis of the Cochrane analysis of 2015, advantages and disadvantages for children and pregnant women are explained...
September 15, 2017: Zeitschrift Für Geburtshilfe und Neonatologie
https://www.readbyqxmd.com/read/28913129/evaluating-the-content-and-quality-of-intrapartum-care-in-vaginal-births-an-example-of-a-state-hospital
#8
Zekiye Karaçam, Döndü Arslan Kurnaz, Gizem Güneş
OBJECTIVE: The purpose of the research was to assess the content and quality of the intrapartum care offered in vaginal births in Turkey, based on the example of a state hospital. MATERIALS AND METHODS: This cross-sectional study was conducted between January 1(st), 2013 and December 31(st), 2014 at Aydın Maternity and Children's Hospital. The study sample consisted of 303 women giving vaginal birth, who were recruited into the study using the method of convenience sampling...
March 2017: Turk J Obstet Gynecol
https://www.readbyqxmd.com/read/28901007/pharmacological-and-mechanical-interventions-for-labour-induction-in-outpatient-settings
#9
REVIEW
Joshua P Vogel, Alfred O Osoti, Anthony J Kelly, Stefania Livio, Jane E Norman, Zarko Alfirevic
BACKGROUND: Induction of labour is carried out for a variety of indications and using a range of methods. For women at low risk of pregnancy complications, some methods of induction of labour or cervical ripening may be suitable for use in outpatient settings. OBJECTIVES: To examine pharmacological and mechanical interventions to induce labour or ripen the cervix in outpatient settings in terms of effectiveness, maternal satisfaction, healthcare costs and, where information is available, safety...
September 13, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28887017/establishment-and-activity-of-the-d-quadrant-organizer-in-the-marine-gastropod-crepidula-fornicata
#10
Jonathan Q Henry, Deirdre C Lyons, Kimberly J Perry, Chen Cornelia Osborne
During development in metazoan embryos, the fundamental embryonic axes are established by organizing centers that influence the fates of nearby cells. Among the spiralians, a large and diverse branch of protostome metazoans, studies have shown that an organizer sets up the dorsal-ventral axis, which arises from one of the four basic cell quadrants during development (the dorsal, D quadrant). Studies in a few species have also revealed variation in terms of how and when the D quadrant and the organizer are established...
September 5, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28886747/women-s-views-and-experiences-of-two-alternative-consent-pathways-for-participation-in-a-preterm-intrapartum-trial-a-qualitative-study
#11
Alexandra Sawyer, Celine Chhoa, Susan Ayers, Angela Pushpa-Rajah, Lelia Duley
BACKGROUND: The Cord Pilot Trial compared alternative policies for timing of cord clamping at very preterm birth at eight UK hospitals. In addition to standard written consent, an oral assent pathway was developed for use when birth was imminent. The aim of this study was to explore women's views and experiences of two alternative consent pathways to participate in the Cord Pilot Trial. METHODS: We conducted a qualitative study using semi-structured interviews. A total of 179 participants in the Cord Pilot Trial were sent a postal invitation to take part in interviews...
September 9, 2017: Trials
https://www.readbyqxmd.com/read/28867510/role-of-metformin-for-ovulation-induction-in-infertile-patients-with-polycystic-ovary-syndrome-pcos-a-guideline
#12
(no author information available yet)
Metformin alone compared with placebo increases the ovulation rate in women with polycystic ovary syndrome (PCOS) but should not be used as first-line therapy for anovulation because oral ovulation induction agents such as clomiphene citrate (CC) or letrozole alone are much more effective in increasing ovulation, pregnancy, and live-birth rates in women with PCOS. There is fair evidence that metformin alone does not increase rates of miscarriage when stopped at the initiation of pregnancy and insufficient evidence that metformin in combination with other agents used to induce ovulation increases live-birth rates...
August 10, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28865539/role-of-metformin-for-ovulation-induction-in-infertile-patients-with-polycystic-ovary-syndrome-pcos-a-guideline
#13
(no author information available yet)
Metformin alone compared with placebo increases the ovulation rate in women with polycystic ovary syndrome (PCOS) but should not be used as first-line therapy for anovulation because oral ovulation induction agents such as clomiphene citrate or letrozole alone are much more effective in increasing ovulation, pregnancy, and live-birth rates in women with PCOS. There is fair evidence that metformin alone does not increase rates of miscarriage when stopped at the initiation of pregnancy and insufficient evidence that metformin in combination with other agents used to induce ovulation increases live-birth rates...
September 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28864930/contemporary-epidemiology-and-novel-predictors-of-uterine-rupture-a-nationwide-population-based-study
#14
Gustavo Vilchez, Sarah Nazeer, Komal Kumar, Morgan Warren, Jing Dai, Robert J Sokol
PURPOSE: In spite of several policies aiming to decrease cesarean rates and related complications such as uterine rupture, data show that uterine rupture and associated morbidity are increasing along the years. Whether previously unidentified risk factors are currently playing an important role on these trends is unknown. We analyze current risks of uterine rupture and main preceding factors from more recent years compared to former data. METHODS: All uterine rupture cases in the US from 2011-2012 were selected, with matched non-uterine rupture cases selected as controls...
September 1, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28854590/double-blind-randomized-controlled-trial-of-letrozole-versus-clomiphene-citrate-in-subfertile-women-with-polycystic-ovarian-syndrome
#15
S A Amer, J Smith, A Mahran, P Fox, A Fakis
STUDY QUESTION: Would letrozole as a primary ovulation induction agent generate better pregnancy rates than clomiphene citrate (CC) in subfertile women with anovulatory polycystic ovarian syndrome (PCOS)? SUMMARY ANSWER: Participants receiving letrozole as a primary treatment achieved a significantly (P = 0.022) higher clinical pregnancy rate per patient (61.2%) compared to CC (43.0%). WHAT IS KNOWN ALREADY: According to a recent Cochrane systematic review (2014), letrozole appears to improve live-birth (LB) and pregnancy rates in anovulatory women with PCOS, compared to CC...
August 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28846670/single-immunoglobulin-interleukin-1-related-receptor-sigirr-regulates-vulnerability-to-tlr4-mediated-necrotizing-enterocolitis-in-a-mouse-model
#16
Jason Fawley, Alain Cuna, Heather L Menden, Steven McElroy, Shahid Umar, Scott R Welak, David M Gourlay, Xiaoxia Li, Venkatesh Sampath
BACKGROUND: Mechanisms underlying aberrant activation of intestinal Toll-Like Receptor 4 (TLR4) signaling in necrotizing enterocolitis (NEC) remain unclear. In this study, we examined the role of Single Immunoglobulin Interleukin-1 Receptor Related Molecule (SIGIRR), an inhibitor of TLR signaling, in modulating experimental NEC vulnerability in mice. METHODS: Experimental NEC was induced in neonatal wild-type and SIGIRR-/- mice using hypoxia, formula feeding, and lipopolysaccharide administration...
August 28, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28842437/hypoxia-promotes-primitive-glycosaminoglycan-rich-extracellular-matrix-composition-in-developing-heart-valves
#17
Dorothy Amofa, Alexia Hulin, Yuji Nakada, Hesham A Sadek, Katherine E Yutzey
During postnatal heart valve development, glycosaminoglycan (GAG)-rich valve primordia transform into stratified valve leaflets composed of GAGs, fibrillar collagen, and elastin layers accompanied by decreased cell proliferation, as well as thinning and elongation. The neonatal period is characterized by the transition from a uterine environment to atmospheric oxygen, but the role of changing O2 levels in valve extracellular matrix (ECM) composition or morphogenesis are not well-characterized. Here, we show that tissue hypoxia decreases in mouse aortic valves in the days after birth, concomitant with ECM remodeling and cell cycle arrest of valve interstitial cells (VICs)...
August 25, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28838804/castor-oil-as-a-natural-alternative-to-labor-induction-a-retrospective-descriptive-study
#18
Andrea L DeMaria, Beth Sundstrom, Grace E Moxley, Kendall Banks, Ashlan Bishop, Lesley Rathbun
AIM: To describe birthing outcomes among women who consumed castor oil cocktail as part of a freestanding birth center labor induction protocol. METHODS: De-identified data from birth logs and electronic medical records were entered into SPSS Statistics 22.0 for analysis for all women who received the castor oil cocktail (n=323) to induce labor between January 2008 and May 2015 at a birth center in the United States. Descriptive statistics were analyzed for trends in safety and birthing outcomes...
August 21, 2017: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/28831553/efficacy-and-safety-of-misoprostol-dinoprostone-and-cook-s-balloon-for-labour-induction-in-women-with-foetal-growth-restriction-at-term
#19
Jorge Duro-Gómez, María Fernanda Garrido-Oyarzún, Ana Belén Rodríguez-Marín, Antonio Jesús de la Torre González, José Eduardo Arjona-Berral, Camil Castelo-Branco
BACKGROUND AND OBJECTIVES: To compare effectiveness and safety of dinoprostone, misoprostol and Cook's balloon as labour-inducing agents in women with intrauterine growth restriction (IUGR) at term. METHODS: Retrospective cohort chart review of women diagnosed with foetal growth restriction at term in Reina Sofia Hospital, Cordoba, Spain from January 2014 to December 2015. Registration of baseline characteristics and method of induction was made. The main outcome was time from induction to delivery...
August 22, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28828329/next-generation-sequencing-and-karyotype-analysis-for-the-diagnosis-of-robertsonian-translocation-type-trisomy-13-a-case-report
#20
Jing Sha, Fumin Liu, Bei Zhang, Yang Huang, Qinglin Zhang, Gao Juan, Jingfang Zhai
Trisomy 13 (Patau syndrome) is the third most common autosomal trisomy with a prevalence between 1 in 10,000 - 20,000 live births. Robertsonian translocations represent the largest number of chromosomal aberrations in human population with an incidence of 1.23 in 1000 live birth and translocation 13;14 is one of the most frequent Robertsonian translocations (approximately 75%). We sampled umbilical vein blood from a 27-yr-old woman whose ultrasonography findings revealed congenital heart defects, single ventricle, polycystic kidney, median cleft lip and palate and holoprosencephaly at gestational age of 23+6 weeks for karyotype and sequencing during intra-amniotic cavity injection of acrinol for labor induction...
June 2017: Iranian Journal of Public Health
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