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Cardiovascular mortality

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https://www.readbyqxmd.com/read/28749273/a-retrospective-review-of-western-lowland-gorilla-gorilla-gorilla-gorilla-mortality-in-european-zoologic-collections-between-2004-and-2014
#1
Victoria Strong, Kerstin Baiker, Marnie L Brennan, Sharon Redrobe, Frank Rietkerk, Malcolm Cobb, Kate White
An understanding of the main causes of mortality among captive gorillas is imperative to promoting their optimal care, health, and welfare. A retrospective observational review of mortality among the European zoo-housed western lowland gorilla ( Gorilla gorilla gorilla) population from 2004 to 2014 was carried out. This is the first published study of mortality in this population. Relevant postmortem data were requested from each collection reporting a death during the study period. Age at death enabled grouping into discrete age categories...
June 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28749197/cardiovascular-benefits-and-safety-of-non-insulin-medications-used-in-the-treatment-of-type-2-diabetes-mellitus
#2
Srikanth Yandrapalli, George Jolly, Adam Horblitt, Abdallah Sanaani, Wilbert S Aronow
Diabetes mellitus is a growing in exponential proportions. If the current growth trend continues, it may result in every third adult in the United States having diabetes mellitus by 2050, and every 10(th) adult worldwide. Type 2 diabetes mellitus (T2DM) confers a 2- to 3-fold increased risk of cardiovascular (CV) events compared with non-diabetic patients, and CV mortality is responsible for around 80% mortality in this population. Patients with T2DM can have other features of insulin resistance-metabolic syndrome like hypertension, lipid abnormalities, and obesity which are all associated with increased CV disease and stroke risk even in the absence of T2DM...
July 27, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/28749067/haemolysis-in-haemodialysis
#3
REVIEW
Dhakshayini Tharmaraj, Peter G Kerr
Haemolysis in haemodialysis, although rare in current times, is associated with significant mortality and morbidity. As such prompt recognition, treatment, analysis of root cause and correction of underlying causative factors is crucial. Dialysate, extracorporeal circuit and patient related factors all contribute to haemolysis risk. Haemolysis can manifest with non-specific signs and symptoms including but not restricted to hypertension, nausea, pain (abdominal, chest, back) and dyspnoea. It may present acutely during the dialysis session or may take a protracted course...
July 27, 2017: Nephrology
https://www.readbyqxmd.com/read/28748993/-sedentary-lifestyle-is-associated-with-metabolic-and-cardiovascular-risk-factors-independent-of-physical-activity
#4
Ana María Leiva, María Adela Martínez, Carlos Cristi-Montero, Carlos Salas, Rodrigo Ramírez-Campillo, Ximena Díaz Martínez, Nicolás Aguilar-Farías, Carlos Celis-Morales
BACKGROUND: Sedentary behavior is a main risk factor for cardiovascular disease and mortality. AIM: To investigate the association between sedentary behavior and metabolic and cardiovascular risk factors. MATERIAL AND METHODS: We assessed 322 participants aged between 18 to 65 years. Physical activity and sedentary behavior were measured with accelerometers (Actigraph®). Body mass index (BMI), waist circumference, percentage of body fat, diet and blood markers (glucose, lipid profile, insulin and HOMA-IR) were measured with standardized protocols...
April 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28748918/different-combinations-of-glucose-tolerance-and-blood-pressure-status-and-incident-cardiovascular-disease-and-all-cause-mortality-events
#5
M A Hajebrahimi, S Akbarpour, A Eslami, F Azizi, F Hadaegh
The purpose of this study was to evaluate the effect of combinations of blood pressure and glucose tolerance status on cardiovascular and all-cause mortality. A total of 7619 participants aged ⩾30 years old were stratified to nine categories as follows: (1) normotension (NTN) and normal glucose tolerance (NGT) (reference group), (2) NTN and pre-diabetes mellitus (pre-DM), (3) NTN and DM, (4) pre-hypertension (pre-HTN) and NGT, (5) pre-HTN and pre-DM, (6) pre-HTN and DM, (7) HTN and NGT, (8) HTN and pre-DM and (9) HTN and DM...
July 27, 2017: Journal of Human Hypertension
https://www.readbyqxmd.com/read/28748877/vitamin-d-levels-and-other-biochemical-parameters-of-mineral-bone-disorders-and-their-association-with-diastolic-dysfunction-and-left-ventricular-mass-in-young-nondiabetic-adult-patients-with-chronic-kidney-disease
#6
Satyendra Kumar Sonkar, Mohit Bhutani, Gyanendra Kumar Sonkar, Sant Kumar Pandey, Sharad Chandra, Vivek Bhosale
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in patients with end-stage renal disease. Chronic kidney disease (CKD)-associated cardiovascular mortality is more prevalent in those with diastolic heart failure and is an early predictor, while increased left ventricular mass (LVM) is a strong independent risk factor. Hypovitaminosis D is extensively being studied as a nontraditional risk factor for CVD. The aim of the present study is to look at the association of Vitamin D and other parameters of mineral bone disorder (MBD) with diastolic dysfunction and LVM in nondiabetic young adult patients with CKD...
July 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28748423/impact-of-interstitial-lung-disease-on-mortality-of-patients-with-rheumatoid-arthritis
#7
Dam Kim, Soo-Kyung Cho, Chan-Bum Choi, Jung-Yoon Choe, Won Tae Chung, Seung-Jae Hong, Jae-Bum Jun, Young Ok Jung, Tae-Hwan Kim, Tae-Jong Kim, Hye-Soon Lee, Joo-Hyun Lee, Jisoo Lee, Shin-Seok Lee, Dae-Hyun Yoo, Bo Young Yoon, Jin Woo Song, Sang-Cheol Bae, Yoon-Kyoung Sung
To identify the prevalence of interstitial lung disease (ILD) in Korean patients with rheumatoid arthritis (RA) and assess its effect on mortality. A total of 3555 patients with RA, with chest X-ray or chest computed tomography (CT) data at enrollment were extracted from the KORean Observational study Network for Arthritis cohort, a nationwide prospective cohort for patients with RA in Korea. The patients were classified into two groups: (1) an ILD group by chest X-ray or chest CT scan, and (2) a non-ILD group by these modalities...
July 26, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28748188/arterial-stiffness-in-symptomatic-smokers-with-normal-lung-function
#8
Nicola Scichilone, Antonino Tuttolomondo, Carlo Maida, Alida Benfante, Jessica Peluso, Anna Cirrincione, Valerio Vassallo, Antonio Pinto
Chronic obstructive pulmonary disease (COPD) is associated with cardiovascular morbidity and mortality. Arterial stiffness and endothelial dysfunction index are validated surrogate cardiovascular markers and are increased in subjects with COPD. We tested whether increased arterial stiffness and endothelial dysfunction occur in symptomatic smokers with no evidence of bronchial obstruction. Clinical and lung functional assessments were conducted in smoker subjects with chronic respiratory symptoms and in COPD patients...
July 2017: ERJ Open Research
https://www.readbyqxmd.com/read/28748119/uric-acid-in-the-pathogenesis-of-metabolic-renal-and-cardiovascular-diseases-a-review
#9
REVIEW
Usama A A Sharaf El Din, Mona M Salem, Dina O Abdulazim
The association between uric acid (UA) on one side and systemic hypertension (Htn), dyslipidemia, glucose intolerance, overweight, fatty liver, renal disease and cardiovascular disease (CVD) on the other side is well recognized. However, the causal relationship between UA and these different clinical problems is still debatable. The recent years have witnessed hundreds of experimental and clinical trials that favored the opinion that UA is a probable player in the pathogenesis of these disease entities. These studies disclosed the strong association between hyperuricemia and metabolic syndrome (MS), obesity, Htn, type 2 diabetes mellitus (DM), non-alcoholic fatty liver disease, hypertriglyceridemia, acute kidney injury, chronic kidney disease (CKD), coronary heart disease (CHD), heart failure and increased mortality among cardiac and CKD patients...
September 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28748118/serum-uric-acid-and-acute-kidney-injury-a-mini-review
#10
REVIEW
Kai Hahn, Mehmet Kanbay, Miguel A Lanaspa, Richard J Johnson, A Ahsan Ejaz
Acute kidney injury causes great morbidity and mortality in both the community and hospital settings. Understanding the etiological factors and the pathophysiological principles resulting in acute kidney injury is essential in prompting appropriate therapies. Recently hyperuricemia has been recognized as a potentially modifiable risk factor for acute kidney injury, including that associated with cardiovascular surgery, radiocontrast administration, rhabdomyolysis, and associated with heat stress. This review discussed the evidence that repeated episodes of acute kidney injury from heat stress and dehydration may also underlie the pathogenesis of the chronic kidney disease epidemic that is occurring in Central America (Mesoamerican nephropathy)...
September 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28747765/troponin-i-and-t-in-relation-to-cardiac-injury-detected-with-electrocardiography-in-a-population-based-cohort-the-maastricht-study
#11
Dorien M Kimenai, Remy J H Martens, Jeroen P Kooman, Coen D A Stehouwer, Frans E S Tan, Nicolaas C Schaper, Pieter C Dagnelie, Miranda T Schram, Carla J H van der Kallen, Simone J S Sep, Jeroen D E van Suijlen, Abraham A Kroon, Otto Bekers, Marja P van Dieijen-Visser, Ronald M A Henry, Steven J R Meex
Interest in high-sensitivity cardiac troponin I(hs-cTnI) and T(hs-cTnT) has expanded from acute cardiac care to cardiovascular disease(CVD) risk stratification. Whether hs-cTnI and hs-cTnT are interchangeable in the ambulant setting is largely unexplored. Cardiac injury is a mechanism that may underlie the associations between troponin levels and mortality in the general population. In the population-based Maastricht Study, we assessed the correlation and concordance between hs-cTnI and hs-cTnT. Multiple regression analyses were conducted to assess the association of hs-cTnI and hs-cTnT with electrocardiographic (ECG) changes indicative of cardiac abnormalities...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28747039/prior-beta-blockers-use-is-independently-associated-with-increased-inpatient-mortality-in-patients-presenting-with-acute-myocardial-infarction
#12
Yan Zhou, Suzhen Chen, Xiang Zhu, Junhong Gui, Khalid Abusaada
BACKGROUND: Beta blockers (BBs) are recommended for patients presenting with acute myocardial infarction. However, the effects of prior BBs use on inpatient mortality in patients presenting with acute myocardial infarction (AMI) are unknown. METHODS: This was a retrospective cohort study of patients presenting with AMI in Florida Hospital Orlando from January 1, 2013 to December 31, 2014. Data were collected prospectively, as part of the Acute Coronary Treatment and Intervention Outcomes Network (ACTION) Registry...
September 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28747021/characteristics-and-outcomes-of-medically-managed-patients-with-non-st-segment-elevation-acute-coronary-syndromes-insights-from-the-multinational-epicor-asia-study
#13
Chee Tang Chin, Tiong K Ong, Rungroj Krittayaphong, Stephen W-L Lee, Jitendra P S Sawhney, Hyo-Soo Kim, Angeles Alonso Garcia, Héctor Bueno, Stuart J Pocock, Vo T Nhan, Ana Vega, Nobuya Hayashi, Yong Huo
BACKGROUND: Many patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS) are medically managed without coronary revascularization. The reasons vary and may impact prognosis. METHODS: EPICOR Asia (NCT01361386) is a prospective study of hospital survivors post-ACS enrolled in 218 hospitals from 8 countries/regions in Asia (06/2011-05/2012). All medically managed NSTE-ACS patients were classified into 3 groups: 1) no coronary angiography (CAG-); 2) non-significant coronary artery disease (CAD) on angiogram (CAG+ CAD-); and 3) significant CAD (CAG+ CAD+)...
September 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28746811/the-acute-effects-of-different-spironolactone-doses-on-cardiac-function-in-streptozotocin-induced-diabetic-rats
#14
Aleksandra Vranic, Stefan Simovic, Petar Ristic, Tamara R Nikolic, Isidora Stojic, Ivan M Srejovic, Vladimir I Zivkovic, Vladimir Jakovljevic, Dusan Djuric
Currently, cardiovascular diseases are leading cause of global mortality, while diabetes mellitus remains an important cause of cardiovascular morbidity. Findings suggest that obesity and diabetes mellitus are closely interconnected with high aldosterone levels, while mineralocorticoid receptors antagonist therapy has shown positive effects on cardiovascular complications associated with diabetes mellitus. A recent study showed that patients with diabetes mellitus treated with mineralocorticoid receptors antagonist have improved coronary microvascular function, leading to improved diastolic dysfunction...
July 26, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28746656/mortality-due-to-noncommunicable-diseases-in-brazil-1990-to-2015-according-to-estimates-from-the-global-burden-of-disease-study
#15
Deborah Carvalho Malta, Elisabeth França, Daisy Maria Xavier Abreu, Rosângela Durso Perillo, Maíra Coube Salmen, Renato Azeredo Teixeira, Valeria Passos, Maria de Fátima Marinho Souza, Meghan Mooney, Mohsen Naghavi
CONTEXT AND OBJECTIVE: Noncommunicable diseases (NCDs) are the leading health problem globally and generate high numbers of premature deaths and loss of quality of life. The aim here was to describe the major groups of causes of death due to NCDs and the ranking of the leading causes of premature death between 1990 and 2015, according to the Global Burden of Disease (GBD) 2015 study estimates for Brazil. DESIGN AND SETTING: Cross-sectional study covering Brazil and its 27 federal states...
May 2017: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/28746470/relationship-between-ventilation-heterogeneity-and-exercise-intolerance-in-adults-with-sickle-cell-anemia
#16
A J Lopes, C L Marinho, U D Alves, C E A Gonçalves, P O Silva, E C Botelho, R Bedirian, A R Soares, M C P Maioli
Sickle cell anemia (SCA) causes dysfunction of multiple organs, with pulmonary involvement as a major cause of mortality. Recently, there has been growing interest in the nitrogen single-breath washout (N2SBW) test, which is able to detect ventilation heterogeneity and small airway disease when the results of other pulmonary function tests (PFTs) are still normal. Thus, the objectives of the present study were to assess the heterogeneity in the ventilation distribution in adults with SCA and to determine the association between the ventilation distribution and the clinical, cardiovascular, and radiological findings...
July 20, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28746145/treatment-and-outcomes-of-type-2-myocardial-infarction-and-myocardial-injury-compared-with-type-1-myocardial-infarction
#17
Nathaniel R Smilowitz, Pritha Subramanyam, Eugenia Gianos, Harmony R Reynolds, Binita Shah, Steven P Sedlis
BACKGROUND: Type 2 myocardial infarction (MI) is defined by a rise and fall of cardiac biomarkers and evidence of ischemia without unstable coronary artery disease (CAD) because of a mismatch in myocardial oxygen supply and demand. Myocardial injury is similar but does not fulfill the clinical criteria for MI. There is uncertainty in terms of the clinical characteristics, management, and outcomes of type 2 MI and myocardial injury in comparison with type 1 MI. PATIENTS AND METHODS: Patients admitted to a Veterans Affairs tertiary care hospital with a rise and fall in cardiac troponin were identified...
July 25, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28744103/clinical-utility-of-evolocumab-in-the-management-of-hyperlipidemia-patient-selection-and-follow-up
#18
REVIEW
Dave L Dixon, Leo F Buckley, Cory R Trankle, Dinesh Kadariya, Antonio Abbate
Inhibition of PCSK9 is a novel therapeutic strategy aimed at reducing low-density-lipoprotein cholesterol (LDL-C) and cardiovascular risk. Evolocumab is a fully humanized monoclonal antibody that inhibits PCSK9, an enzyme that binds to LDL receptors and prevents them from recycling to the hepatocyte surface. Clinical trials have demonstrated 50%-70% reductions in LDL-C with evolocumab when used in combination with statin therapy. The recent FOURIER trial demonstrated that evolocumab further reduces cardiovascular events, but not mortality, in high-risk patients already receiving statin therapy...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28744020/inflammatory-potential-of-diet-and-risk-of-cardiovascular-disease-or-mortality-a-meta-analysis
#19
Xiaoming Zhong, Lin Guo, Lei Zhang, Yanming Li, Ruili He, Guanchang Cheng
Inconsistent findings have reported on the inflammatory potential of diet and cardiovascular disease (CVD) and mortality risk. The aim of this meta-analysis was to investigate the association between the inflammatory potential of diet as estimated by the dietary inflammatory index (DII) score and CVD or mortality risk in the general population. A comprehensive literature search was conducted in PubMed and Embase databases through February 2017. All prospective observational studies assessing the association of inflammatory potential of diet as estimated by the DII score with CVD and all-cause, cancer-related, cardiovascular mortality risk were included...
July 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28743834/mid-arm-muscle-circumference-as-a-substantial-factor-against-mortality-among-people-with-elevated-gamma-gaps
#20
Yuan-Ping Chao, Yi-Fen Lai, Tung-Wei Kao, Tao-Chun Peng, Yuan-Yung Lin, Mu-Tsun Shih, Wei-Liang Chen, Li-Wei Wu
Gamma gap is the difference in total serum proteins and albumin and an elevated gamma gap is related to infections, malignancy, and rheumatic diseases. An elevated gamma gap is also associated with higher mortality due to the correlation with inflammatory status. The study aimed to utilize mid-arm muscle circumference (MAMC) to assist in predicting all-cause mortality, cancer mortality, and cardiovascular mortality in people with elevated gamma gaps. Data were obtained from the third U.S. National Health and Nutrition Examination Survey (1988-1994), which contained 14,011 adults aged 20 to 90 years during up to 14...
July 19, 2017: Oncotarget
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