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Cardiovascular mortality

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https://www.readbyqxmd.com/read/28231268/gamma-glutamyltransferase-and-risk-of-cardiovascular-mortality-a-dose-response-meta-analysis-of-prospective-cohort-studies
#1
Junna Wang, Dandan Zhang, Rongzhong Huang, Xingsheng Li, Wenxiang Huang
BACKGROUND: Serum gamma-glutamyltransferase (GGT) elevation likely contributes to cardiovascular (CV) mortality, however it has remained unknown whether a dose-response relationship exists between serum GGT and CV mortality. METHODS: We searched the PubMed, EMBASE, and Cochrane library databases for prospective cohort studies published up to October 2, 2016. Summary hazard ratios (HRs) with their corresponding 95% confidence intervals (CIs) were calculated using a fixed effects model...
2017: PloS One
https://www.readbyqxmd.com/read/28230811/basigin-rs8259-polymorphism-confers-decreased-risk-of-chronic-heart-failure-in-a-chinese-population
#2
Mu-Peng Li, Xiao-Lei Hu, Yong-Long Yang, Yan-Jiao Zhang, Ji-Peng Zhou, Li-Ming Peng, Jie Tang, Xiao-Ping Chen
Left ventricular remodeling is an essential risk factor contributing to the pathogenesis of chronic heart failure (CHF). Basigin (BSG) promotes cardiovascular inflammation and myocardial remodeling processes by induction of extracellular matrix metalloproteinases and inflammatory cytokines. BSG rs8259 polymorphism was associated with BSG expression and risk of acute coronary syndrome. Therefore, we investigated whether rs8259 polymorphism contributes to risk and prognosis of CHF in Chinese patients. In total 922 adult patients with CHF and 1107 matched healthy controls were enrolled...
February 21, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28229926/the-role-of-frailty-in-explaining-the-association-between-the-metabolic-syndrome-and-mortality-in-older-adults
#3
Emiel O Hoogendijk, Martijn Huisman, Adriana J van Ballegooijen
The association between the metabolic syndrome (MetS) and adverse outcomes in older adults may be explained by other health conditions. This study examined the role of frailty in explaining the association between MetS and mortality, independent of comorbidity. Data were used from 1247 men and women aged ≥65years of the Longitudinal Aging Study Amsterdam. MetS was assessed using the definition of the US National Cholesterol Education Program. Frailty was measured by the frailty phenotype. Mortality was monitored from 1995 until 2015...
February 14, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28229520/association-between-enrolment-in-a-heart-failure-quality-registry-and-subsequent-mortality-a-nationwide-cohort-study
#4
Lars H Lund, Juan-Jesus Carrero, Bahman Farahmand, Karin M Henriksson, Åsa Jonsson, Tomas Jernberg, Ulf Dahlström
AIMS: Heart failure (HF) quality registries report quality of care but it is unknown whether they improve outcomes. The aims were to assess predictors of enrolment in a HF registry, test the hypothesis that enrolment in a HF registry is associated with reduced mortality, and assess potential explanatory factors for this reduction in mortality, if present. METHODS AND RESULTS: We conducted a nationwide prospective cohort study of patients with new-onset HF registered in the Swedish National Patient Registry (NPR, a mandatory registry of ICD-code diagnoses) with or without concurrent registration in the Swedish Heart Failure Registry (SwedeHF, a voluntary quality reporting registry) 2006-2013...
February 23, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28229431/hypertensive-disorders-of-pregnancy
#5
REVIEW
Sahar Naderi, Sandra A Tsai, Abha Khandelwal
PURPOSE OF REVIEW: Although pregnancy-related deaths are rare in the USA, they are on the rise and have more than doubled in the last 20 years. A substantial portion of these deaths are related to cardiovascular disease, specifically hypertensive disorders of pregnancy (HDP). In this review, we will discuss the definitions and proposed pathophysiology of HDP as well as its potential role in cardiovascular morbidity and mortality. RECENT FINDINGS: Placental hypoperfusion may lead to an imbalance in proangiogenic and antiangiogenic factors, notably an increase in soluble fms-like tyrosine kinsase-1 (sFlt-1), thereby leading to endothelial dysfunction...
March 2017: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/28229427/stem-cell-exosomes-cell-freetherapy-for-organ-repair
#6
Mohsin Khan, Raj Kishore
Cardiovascular disease is a significant cause of morbidity and mortality around the world. The damaged cardiac tissue is unable to repair itself following injury warranting the development of alternate therapies. Cell therapy has emerged recently as a viable treatment option resulting in significant improvement in cardiac function. Nevertheless, donated stem cells are hard to find in the heart after transplantation leading to the hypothesis that release of extracellular factors by stem cells is primarily responsible for the beneficial effect of cell therapy...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28229425/optimal-environmental-stiffness-for-stem-cell-mediated-ischemic-myocardium-repair
#7
Honghai Liu, Christian Paul, Meifeng Xu
Cardiovascular diseases related to myocardial infarction (MI) contribute significantly to morbidity and mortality worldwide. The loss of cardiomyocytes during MI is a key factor in the impairment of cardiac-pump functions. Employing cell transplantation has shown great potential as a therapeutic approach in regenerating ischemic myocardium. Several studies have suggested that the therapeutic effects of stem cells vary based on the timing of cell administration. It has been clearly established that the myocardium post-infarction experiences a time-dependent stiffness change, and many studies have highlighted the importance of stiffness (elasticity) of microenvironment on modulating the fate and function of stem cells...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28229135/the-colonic-metabolites-dihydrocaffeic-acid-and-dihydroferulic-acid-are-more-effective-inhibitors-of-in-vitro-platelet-activation-than-their-phenolic-precursors
#8
Gema Baeza, Eva-Maria Bachmair, Sharon Wood, Raquel Mateos, Laura Bravo, Baukje de Roos
Cardiovascular disease (CVD) is the major cause of morbidity and mortality worldwide. The consumption of a healthy diet rich in polyphenols has been inversely associated with the development of CVD. This study evaluated the effects of green coffee bean extract (GCBE) and yerba mate phenolic extract (YMPE), the main phenolic and methylxanthine constituents (5-caffeoylquinic acid, 3,5-dicaffeoylquinic acid, caffeine, and theobromine), and their main metabolites (caffeic acid, ferulic acid, dihydrocaffeic acid (DHCA) and dihydroferulic acid (DHFA)) on platelet activation in vitro...
February 23, 2017: Food & Function
https://www.readbyqxmd.com/read/28228940/beneficial-effects-of-nonpharmacological-interventions-in-the-management-of-essential-hypertension
#9
REVIEW
Anastasios Vamvakis, Eugenia Gkaliagkousi, Areti Triantafyllou, Eleni Gavriilaki, Stella Douma
Essential hypertension is a major health problem causing excess cardiovascular morbidity and mortality. Management of essential hypertension consists of pharmacological and nonpharmacological interventions. In order to prevent and/or treat hypertension, parameters like nutrition, body weight, and physical exercise should be evaluated and taken under consideration for improvement. A large body of evidence clearly support that the role of salt, alcohol, fruits, and vegetables is important for high blood pressure...
January 2017: JRSM Cardiovascular Disease
https://www.readbyqxmd.com/read/28228693/health-benefits-of-dietary-whole-grains-an-umbrella-review-of-meta-analyses
#10
REVIEW
Marc P McRae
OBJECTIVE: The purpose of this study is to review the effectiveness of the role of whole grain as a therapeutic agent in type 2 diabetes, cardiovascular disease, cancer, and obesity. METHODS: An umbrella review of all published meta-analyses was performed. A PubMed search from January 1, 1980, to May 31, 2016, was conducted using the following search strategy: (whole grain OR whole grains) AND (meta-analysis OR systematic review). Only English language publications that provided quantitative statistical analysis on type 2 diabetes, cardiovascular disease, cancer, and weight loss were retrieved...
March 2017: Journal of Chiropractic Medicine
https://www.readbyqxmd.com/read/28228461/sex-differences-in-inflammatory-markers-and-health-status-among-young-adults-with-acute-myocardial-infarction-results-from-the-virgo-variation-in-recovery-role-of-gender-on-outcomes-of-young-acute-myocardial-infarction-patients-study
#11
Yuan Lu, Shengfan Zhou, Rachel P Dreyer, Erica S Spatz, Mary Geda, Nancy P Lorenze, Gail D'Onofrio, Judith H Lichtman, John A Spertus, Paul M Ridker, Harlan M Krumholz
BACKGROUND: Young women (≤55 years of age) with acute myocardial infarction (AMI) have higher mortality risk than similarly aged men. Elevated inflammatory markers are associated with an increased risk of cardiovascular outcomes after AMI, but little is known about whether young women have higher inflammatory levels after AMI compared with young men. METHODS AND RESULTS: We assessed sex differences in post-AMI inflammatory markers and whether such differences account for sex differences in 12-month health status, using data from 2219 adults with AMI, 18 to 55 years of age, in the United States...
February 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28228455/young-women-with-acute-myocardial-infarction-current-perspectives
#12
Rachel P Dreyer, Christopher Sciria, Erica S Spatz, Basmah Safdar, Gail D'Onofrio, Harlan M Krumholz
In recent years, there has been growing public awareness and increasing attention to young women with acute myocardial infarction (AMI), who represent an extreme phenotype. Young women presenting with AMI may develop coronary disease by different mechanisms and often have worse recoveries, with higher risk for morbidity and mortality compared with similarly aged men. The purpose of this cardiovascular perspective piece is to review recent studies of AMI in young women. More specifically, we emphasize differences in the epidemiology, diagnosis, and management of AMI in young women (when compared with men) across the continuum of care, including their pre-AMI, in-hospital, and post-AMI periods, and highlight gaps in knowledge and outcomes that can inform the next generation of research...
February 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28228454/sex-differences-in-long-term-mortality-after-stroke-in-the-instruct-international-stroke-outcomes-study-a-meta-analysis-of-individual-participant-data
#13
Hoang T Phan, Christopher L Blizzard, Mathew J Reeves, Amanda G Thrift, Dominique Cadilhac, Jonathan Sturm, Emma Heeley, Petr Otahal, Vemmos Konstantinos, Craig Anderson, Priya Parmar, Rita Krishnamurthi, Suzanne Barker-Collo, Valery Feigin, Yannick Bejot, Norberto L Cabral, Antonio Carolei, Simona Sacco, Nicolas Chausson, Stephane Olindo, Peter Rothwell, Carolina Silva, Manuel Correia, Rui Magalhães, Peter Appelros, Janika Kõrv, Riina Vibo, Cesar Minelli, Seana Gall
BACKGROUND: Women are reported to have greater mortality after stroke than men, but the reasons are uncertain. We examined sex differences in mortality at 1 and 5 years after stroke and identified factors contributing to these differences. METHODS AND RESULTS: Individual participant data for incident strokes were obtained from 13 population-based incidence studies conducted in Europe, Australasia, South America, and the Caribbean between 1987 and 2013. Data on sociodemographics, stroke-related factors, prestroke health, and 1- and 5-year survival were obtained...
February 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28228117/the-association-between-consecutive-days-heat-wave-and-cardiovascular-disease-mortality-in-beijing-china
#14
Qian Yin, Jinfeng Wang
BACKGROUND: Although many studies have examined the effects of heat waves on the excess mortality risk (ER) posed by cardiovascular disease (CVD), scant attention has been paid to the effects of various combinations of differing heat wave temperatures and durations. We investigated such effects in Beijing, a city of over 20 million residents. METHODS: A generalized additive model (GAM) was used to analyze the ER of consecutive days' exposure to extreme high temperatures...
February 23, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28227734/detection-of-workplace-sedentary-behavior-using-thermal-sensors
#15
J Synnott, J Rafferty, C D Nugent, J Synnott, J Rafferty, C D Nugent, J Synnott, J Rafferty, C D Nugent
Sedentary behavior has been linked to leading causes of morbidity and mortality, including cancer, cardiovascular disease and diabetes. Those who work in office workplaces are susceptible to higher levels of sedentary behavior during the working day. This paper introduces a novel approach to the detection of sedentary behavior through the use of a thermal sensor mounted on the ceiling above a busy workspace. This solution was found to more accurately record 7 out of 10 activity metrics in comparison to self-assessment, when compared to chair pressure sensor recordings...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227704/comparing-glucose-and-insulin-data-from-the-two-hour-oral-glucose-tolerance-test-in-metabolic-syndrome-subjects-and-marathon-runners
#16
Miguel Altuve, Gilberto Perpinan, Erika Severeyn, Sara Wong, Miguel Altuve, Gilberto Perpinan, Erika Severeyn, Sara Wong, Sara Wong, Gilberto Perpinan, Erika Severeyn
Glucose is the main energy source of the body's cells and is essential for normal metabolism. Two pancreatic hormones, insulin and glucagon, are involved in glucose home-ostasis. Alteration in the plasma glucose and insulin concentrations could lead to distinct symptoms and diseases, ranging from mental function impairment to coma and even death. Type 2 diabetes, insulin resistance and metabolic syndrome are typical examples of abnormal glucose metabolism that increase the risk for cardiovascular disease and mortality...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227702/socioeconomic-status-age-and-heart-rate-variability-in-a-bangladeshi-community
#17
Nishat E-Sharmin Trisha, Herbert F Jelinek, Mika P Tarvainen, David J Cornforth, Dewan S Alam, Megan Smith, Nishat E-Sharmin Trisha, Herbert F Jelinek, Mika P Tarvainen, David J Cornforth, Dewan S Alam, Megan Smith, Herbert F Jelinek, David J Cornforth, Megan Smith, Nishat E-Sharmin Trisha, Dewan S Alam, Mika P Tarvainen
Socioeconomic status (SES) is a risk factor for cardiovascular disease (CVD) and either low or high heart rate variability (HRV) at rest has been shown to predict cardiovascular morbidity and mortality. The study investigated the extent HRV features can predict SES. Four hundred and twenty eight people were randomly selected from the commercial districts (high SES) and slum areas (low SES) within Dhaka city. Demographic, clinical, and HRV features were recorded. Of the clinical variables age, waist circumference and diastolic blood pressure (p<;0...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227423/dynamic-mapping-of-ventricular-function-from-cardiovascular-magnetic-resonance-imaging
#18
Maria Panayiotou, Peter Mountney, Alexander Brost, Daniel Toth, Tom Jackson, Jonathan M Behar, Christopher A Rinaldi, R James Housden, Kawal S Rhode, Maria Panayiotou, Peter Mountney, Alexander Brost, Daniel Toth, Tom Jackson, Jonathan M Behar, Christopher A Rinaldi, R James Housden, Kawal S Rhode, Alexander Brost, Tom Jackson, Maria Panayiotou, Christopher A Rinaldi, Jonathan M Behar, R James Housden, Kawal S Rhode, Daniel Toth, Peter Mountney
Heart failure is associated with substantial mortality and morbidity and remains the most common diagnosis in older patients. Based on experimental electrophysiologic studies, cardiac resynchronization therapy (CRT) for heart failure results in a maximum resynchronization effect when applied to the most delayed left ventricular (LV) site. Current clinical practice is to identify the optimal site using separate visualisation of scar and activation information. These must be mentally mapped into 3D, which is challenging and time-consuming for the electrophysiologist...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226875/dihydrocapsaicin-induced-hypothermia-after-asphyxiai-cardiac-arrest-in-rats
#19
Junyun He, Leanne Young, Xiaofeng Jia, Junyun He, Leanne Young, Xiaofeng Jia, Xiaofeng Jia, Leanne Young, Junyun He
Cardiac arrest (CA) is one of the leading causes of mortality and morbidity in the world. Fast, reversible and controllable pharmaceutical-induced hypothermia (PIH) is strongly desired to treat ischemia-reperfusion brain injury. Dihydrocapsaicin (DHC), an agonist of transient receptor potential vanilloid type 1 cation channel (TRPV1), is an emerging candidate for PIH. Its capability to lower body temperature has been validated in both healthy and stroke animal models. However, DHC has shown cardiovascular effects and its safety and feasibility in a CA model has not been tested...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226276/different-associations-of-albuminuria-with-total-and-cardiovascular-mortality-by-concentrations-of-persistent-organic-pollutants-in-the-elderly
#20
Hyun-Woo Kim, Jung-Hyun Kim, Dong-Won Lee, Sang-Hyun Cho, Ji-Hoon Jung, Ki-Su Kim, Duk-Hee Lee
Epidemiologic studies have indicated that albuminuria is associated with mortality from all causes and cardiovascular disease (CVD), with substantial heterogeneity. We evaluated if the associations of urine albumin creatinine ratio (ACR) with all-cause and CVD mortality differed depending on serum concentrations of persistent organic pollutants (POPs), strong lipophilic chemical mixtures with very long half-lives, which are recently linked to many degenerative diseases. Study subjects were participants of the National Health and Nutrition Examination Survey 1999-2004 who were 60 years or older at baseline (n=1215 and 1067 for organochlorine pesticides (OCPs) and other POPs, respectively)...
February 18, 2017: Environmental Research
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