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JOURNAL ARTICLE
Corrilynn O Hileman, Shahdi K Malakooti, Nirav Patil, Nora G Singer, Grace A McComsey
INTRODUCTION: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) may trigger autoimmune disease (AD) through initial innate immune activation with subsequent aberrations in adaptive immune cells leading to AD. While there are multiple reports of incident AD diagnosed after COVID-19, the risk in the context of key circulating strains is unknown. METHODS: TriNetX, a global, federated, health research network providing access to electronic medical records across 74 healthcare organizations, was utilized to define an adult cohort between January 1, 2020, and March 3, 2023...
2024: Frontiers in Immunology
#22
JOURNAL ARTICLE
Hilde Van Parijs, Yves Sinove, Marilyn Carprieaux, Mark De Ridder
BACKGROUND: Radiation therapy is often indicated as part of the treatment for breast cancer and is therefore used frequently worldwide. Vasculopathy is a general term used to describe any condition that affects blood vessels. We present a case report of a patient who presented with vasculopathy as a rare late side effect of radiation therapy to the breast. CASE PRESENTATION: This 66-year-old woman was initially treated with breast-conserving surgery for early-stage receptor-positive left breast carcinoma...
February 21, 2024: World Journal of Surgical Oncology
#23
Paul T Akins
INTRODUCTION: Presenting symptoms of atrial myxoma are classically viewed as a triad of cardiac, embolic, and constitutional symptoms. Dermatologic manifestations are viewed as constitutional symptoms and have not received much attention. METHODS: Illustrative case presentation and literature review. RESULTS: I admitted a 28 y woman transferred to the comprehensive stroke center with an ischemic stroke treated with intravenous thrombolysis...
February 29, 2024: Heliyon
#24
JOURNAL ARTICLE
Yuya Tanaka, Takehiko Kobayashi, Shigeki Shimizu, Yu Kurahara
No abstract text is available yet for this article.
February 19, 2024: Internal Medicine
#25
JOURNAL ARTICLE
Ozge Sevil Karstarli Bakay, Nida Kacar, Melis Gonulal, Nese Calli Demirkan, Hülya Cenk, Sule Goksin, Yunus Gural
INTRODUCTION: Dermoscopy has become widespread in the diagnosis of inflammatory skin diseases. Cutaneous vasculitis (CV) is characterized by inflammation of vessels, and a rapid and reliable technique is required for the diagnosis. OBJECTIVES: We aimed to define CV dermoscopic features and increase the diagnostic accuracy of dermoscopy with machine learning (ML) methods. METHODS: Eighty-nine patients with clinically suspected CV were included in the study...
January 1, 2024: Dermatology Practical & Conceptual
#26
Manasa Srinivasa Murthy, Dhanush Hoskere, Harish Veerapalli, Eiton Arroyo Rodriguez
Myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA) vasculitis manifests as a neutrophilic inflammation impacting small vessels across multiple organs, notably the lungs, kidneys, and skin. We present a unique case of MPO-ANCA vasculitis in a 77-year-old female characterized by glomerulosclerosis, rapidly progressive renal failure necessitating hemodialysis (HD), bullous skin lesions, and hypoxic respiratory failure. The patient, who had a history of type 2 diabetes, presented with progressive dyspnea, hypoxia, and acute kidney injury superimposed on chronic kidney disease (CKD) progressing to renal failure requiring dialysis...
January 2024: Curēus
#27
JOURNAL ARTICLE
Eduardo Liquidano-Perez, Gibert Maza-Ramos, Bethy Alexandra Perez Arias, Saul Oswaldo Lugo Reyes, Tania Barragan Arevalo, Sara Alejandra Solorzano-Morales, Edna Venegas Montoya, Aidé Tamara Staines-Boone, Rogelio Guzmán Cotaya, Satoshi Okada, Capucine Picard, Etienne Patin, Nideshda Ramirez-Uribe, Juan Carlos Bustamante-Ogando, Selma Cecilia Scheffler-Mendoza, Marco Antonio Yamazaki-Nakashimada, Marimar Saez-de-Ocariz, Sara Elva Espinosa Padilla, Maria Edith Gonzalez-Serrano
PURPOSE: We aimed to describe the clinical, immunological, and genetic features of patients with DOCK8 deficiency (DOCK8-Def) in a tertiary care center for children. METHODS: Retrospective chart review of patients' clinical, immunological, and genetic characteristics with DOCK8-Def. Genetic analysis was performed with targeted- or whole-exome sequencing; we also assessed DOCK8 protein expression and a lymphoproliferation assay and analyzed survival by the Kaplan-Meier method...
February 2024: Pediatric Allergy and Immunology
#28
JOURNAL ARTICLE
Judith Eschbach, Alain Wagner, Corinne Beahr, Akkiz Bekel, Anne-Sophie Korganow, Angelique Quartier, Jean-Christophe Peter, Pierre Eftekhari
Drug repurposing is used to propose new therapeutic perspectives. Here, we introduce "Drug Upgrade", that is, characterizing the mode of action of an old drug to generate new chemical entities and new therapeutics. We proposed a novel methodology covering target identification to pharmacology validation. As an old drug, we chose hydroxychloroquine (HCQ) for its well-documented clinical efficacy in lupus and its side effect, retinal toxicity. Using the Nematic Protein Organization Technique (NPOT®) followed by liquid chromatography-tandem mass spectrometry analyses, we identified myeloperoxidase (MPO) and alpha-crystallin β chain (CRYAB) as primary and secondary targets to HCQ from lupus patients' peripheral blood mononuclear cells (PBMCs) and isolated human retinas...
February 2024: Drug Development Research
#29
JOURNAL ARTICLE
Keiko Furuoka, Takeshi Fukumoto, Yoshiyuki Masuda, Ayano Tanigawa, Hiroshi Kosaka, Tohru Nagano
Varicella zoster virus (VZV) infection may cause large or medium vessel vasculitis, including granulomatous arteritis of the nervous system and central nervous system vasculitis. However, small vessel vasculitis, such as cutaneous leukocytoclastic vasculitis (LCV) associated with localized cutaneous VZV infection, herpes zoster, is uncommon. Herein, we present the case of a 75- year-old man with segmental leukocytoclastic vasculitis associated with herpes zoster on the leg. To the best of our knowledge, there are four cases of segmental leukocytoclastic vasculitis in herpes zoster reported in the English literature; we compared our case with these previous reports...
December 1, 2023: Dermatology Reports
#30
JOURNAL ARTICLE
Nam V Nguyen, Farid Khan, Andrew Cannon, Ye Huang, Lucas Kim, Rena Xu, Pukhraj Rishi, Christopher D Conrady, Timothy C Greiner, Ana Yuil-Valdes, Steven Yeh
PURPOSE: To report a case of primary vitreoretinal lymphoma masquerading as infectious retinitis that was diagnosed via a retinal biopsy. OBSERVATIONS: A 72-year-old female patient was referred to our ophthalmology clinic for evaluation of retinitis and vasculitis in the right eye (OD). On examination, best-corrected visual acuities (BCVAs) were hand motions OD and 20/20 in the left eye (OS). Fundus examination revealed optic disc edema and diffuse retinal whitening superior to the superotemporal arcade OD...
February 7, 2024: Journal of Ophthalmic Inflammation and Infection
#31
JOURNAL ARTICLE
Karina Felipe Fernandes Maciel, Antonio Henrique Cordeiro, Rivadavio Fernandes Batista de Amorim, Ludmila Bertti Coelho, Mariana de Freitas Cordeiro, Thiago David Alves Pinto
BACKGROUND Leukocytoclastic vasculitis (LCV) is an atypical form of cutaneous paraneoplastic manifestation. Its association with multiple myeloma (MM) is even rarer and is associated with poor prognosis and short survival, regardless of the therapy instituted. Different treatment approaches are necessary. We present a case in which LCV was the first manifestation of MM, and high-intensity laser therapy (HILT) was used as an option to accelerate healing and control pain. CASE REPORT A 76-year-old woman presented with pain and paresthesia in her lower limbs, associated with palpable purpura...
February 7, 2024: American Journal of Case Reports
#32
JOURNAL ARTICLE
Akerke Auanassova, Marlen Yessirkepov
Systemic vasculitides are the most complex and problematic autoimmune rheumatic diseases characterized by affections of large, medium, or small vessels. Although the immunopathogenesis of vasculitides is thoroughly studied, the epidemiology and etiology are poorly explored. The main triggers of vasculitides are environmental, genetic, and various infectious factors. Diagnosis of vasculitides is complicated due to the non-specific nature of their symptoms. Vasculitides affect various organ systems with abrupt or slow (weeks-months) development of symptoms...
April 2024: Rheumatology International
#33
JOURNAL ARTICLE
Jordan Phillipps, Carine Lama, John Strickley, Amy Musiek
No abstract text is available yet for this article.
February 2, 2024: Journal of the American Academy of Dermatology
#34
D Rodriguez-Baeza, E Pérez-López, C Román-Curto, A Santos-Briz
No abstract text is available yet for this article.
January 31, 2024: Actas Dermo-sifiliográficas
#35
JOURNAL ARTICLE
E Bodakçi
OBJECTIVE: Single-organ cutaneous small-vessel vasculitis (SoCSVV) is an inflammatory skin-limited vascular disease affecting the dermal and/or hypodermal vessel wall. Pathogenetically, idiopathic forms are described, as well as the induction from different triggers, such as infections, drugs, and vaccines. Following the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic outbreak, cases of cutaneous vasculitis induced by both COVID-19 and COVID-19 vaccinations have been reported in literature...
January 2024: European Review for Medical and Pharmacological Sciences
#36
JOURNAL ARTICLE
Arash Pour Mohammad, Elahe Noroozi, Milad Gholizadeh Mesgarha, Nasrin Shayanfar, Azadeh Goodarzi
INTRODUCTION: Mucocutaneous complications or adverse events due to SARS-CoV-2 infection or vaccination have been well delineated in the literature, respectively. Most eruptions are considered mild and self-limiting; however, for the atypical cases with a tentative clinical diagnosis, performing a biopsy and histopathological assessment is pivotal to confirm the diagnosis and subsequently prescribe a more tailored treatment. Despite the diverse reporting of such incidents globally, most studies restrict the rate of biopsied cases to less than 15%...
2024: Case Reports in Dermatology
#37
JOURNAL ARTICLE
Jaspriya Sandhu, Shriya Garg, Sunil K Gupta, Harpreet Kaur, Aminder Singh
No abstract text is available yet for this article.
2024: Indian Dermatology Online Journal
#38
REVIEW
Blair W Harris, Luke Maxfield, Abigail Hunter, Mandy Alhajj, Byung Ban, Kayd J Pulsipher
BACKGROUND: Henoch-Schönlein purpura (HSP), a leukocytoclastic small vessel vasculitis, exhibits both cutaneous and systemic manifestations. While predominantly observed in childhood, it may manifest in adults with more pronounced systemic involvement. Furthermore, HSP is a global phenomenon showcasing epidemiological and systemic variances. OBJECTIVE: This study aims to scrutinize extracutaneous manifestations in adults with HSP, discerning distinctions according to geographical regions on a worldwide scale...
January 25, 2024: JMIR dermatology
#39
JOURNAL ARTICLE
Sean J Barbour, Rosanna Coppo, Lee Er, Evangeline Pillebout, Maria Luisa Russo, Charles E Alpers, Agnes B Fogo, Franco Ferrario, J Charles Jennette, Ian S D Roberts, H Terence Cook, Jie Ding, Baige Su, Xuhui Zhong, Fernando C Fervenza, Ladan Zand, Licia Peruzzi, Laura Lucchetti, Ritsuko Katafuchi, Yuko Shima, Norishige Yoshikawa, Daisuke Ichikawa, Yusuke Suzuki, Luisa Murer, Robert J Wyatt, Raoul D Nelson, JoAnn H Narus, Scott Wenderfer, Duvuru Geetha, Eric Daugas, Renato C Monteiro, Shinya Nakatani, Antonio Mastrangelo, Matti Nuutinen, Mikael Koskela, Lutz T Weber, Agnes Hackl, Martin Pohl, Carmine Pecoraro, Nobuo Tsuboi, Takashi Yokoo, Ito Takafumi, Shouichi Fujimoto, Giovanni Conti, Domenico Santoro, Marco Materassi, Hong Zhang, Sufang Shi, Zhi-Hong Liu, Vladimir Tesar, Dita Maixnerova, Carmen Avila-Casado, Ingeborg Bajema, Antonella Barreca, Jan U Becker, Jessica M Comstock, Virgilius Cornea, Karen Eldin, Loren Herrera Hernandez, Jean Hou, Kensuke Joh, Mercury Lin, Nidia Messias, Andrea Onetti Muda, Fabio Pagni, Francesca Diomedi-Camassei, Heikki Tokola, Maria D'Armiento, Maximilian Seidl, Avi Rosenberg, Aurélie Sannier, Maria Fernanda Soares, Suxia Wang, Caihong Zeng, Mark Haas
BACKGROUND: Nephritis is a common manifestation of IgA vasculitis and is morphologically indistinguishable from IgA nephropathy. While MEST-C scores are predictive of kidney outcomes in IgA nephropathy, their value in IgA vasculitis nephritis has not been investigated in large multiethnic cohorts. METHODS: Biopsies from 262 children and 99 adults with IgA vasculitis nephritis (N=361) from 23 centers in North America, Europe and Asia were independently scored by 3 pathologists...
January 23, 2024: Clinical Journal of the American Society of Nephrology: CJASN
#40
REVIEW
Immunohistochemical analysis of myeloperoxidase expression in cutaneous leucocytoclastic vasculitis.
Sarra Ben Rejeb, Dorsaf Beltaifa, Yasmine Ben Romdhane, Khadija Bellil
Myeloperoxidase (MPO) is a pro-oxidant enzyme mainly found in the azurophilic granules of neutrophils. It not only displays a key role in the intracellular microbial killing process but also contributes to the extracellular clearance of several pathogens. This study aimed to detect MPO in cutaneous leukocytoclastic vasculitis (LCV) using immunohistochemistry. We retrospectively collected 22 confirmed cases of skin LCV diagnosed in our pathology department over 11 years (2012-2023). Immunohistochemistry was performed using anti-myeloperoxidase antibody (Leica clone 59A5) on the LeicaBond MAX automated system, following manufacturer's instructions...
January 23, 2024: Journal of Immunoassay & Immunochemistry
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