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https://www.readbyqxmd.com/read/27920522/incorporation-of-heparin-binding-proteins-into-preformed-dextran-sulfate-chitosan-nanoparticles
#1
Paula Zaman, Julia Wang, Adam Blau, Weiping Wang, Tina Li, Daniel S Kohane, Joseph Loscalzo, Ying-Yi Zhang
Incorporation of proteins into dextran sulfate (DS)-chitosan (CS) nanoparticles (DSCS NPs) is commonly performed using entrapment procedures, in which protein molecules are mixed with DS and CS until particle formation occurs. As DS is an analog of heparin, the authors examined whether proteins could be directly incorporated into preformed DSCS NPs through a heparin binding domain-mediated interaction. The authors formulated negatively-charged DSCS NPs, and quantified the amount of charged DS in the outer shell of the particles...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27919817/selective-adsorption-of-cr-vi-ions-from-aqueous-solutions-using-cr-6-imprinted-pebax-chitosan-go-aptes-nanofibrous-adsorbent
#2
Mohammadmahdi Etemadi, Saman Samadi, Shabnam Sharif Yazd, Pooya Jafari, Negin Yousefi, Majid Aliabadi
In the present study, a novel Cr(6+)-imprinted Pebax/chitosan/GO/APTES nanofibrous adsorbent (Cr(6+)-PCGA) was prepared and its performance was compared with PCGA nanofibers for selective sorption of Cr(VI) ions from aqueous solutions. The prepared nanofibers were characterized using FTIR, SEM and EDAX analysis. The influence of batch sorption experiments including GO/APTES content, pH, contact time, Cr(VI) initial concentration and temperature on the Cr(VI) sorption efficiency using synthesized nanofibers was investigated...
December 2, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27919553/the-enhanced-reduction-of-c-and-n-dbp-formation-in-treatment-of-source-water-containing-microcystis-aeruginosa-using-a-novel-ctsac-composite-coagulant
#3
Chunxia Ma, Haiyan Pei, Wenrong Hu, Yuting Wang, Hangzhou Xu, Yan Jin
This study investigated the effect of a chitosan-aluminium chloride (CTSAC) composite coagulation process on reducing the formation of algal organic matters (AOM) related carbonaceous disinfection by-products (C-DBPs) and nitrogenous disinfection by-products (N-DBPs), by removing or adsorbing their precursors. Compared with aluminium chloride (AC) and chitosan (CTS) alone, CTSAC significantly enhanced the removal of dissolved organic matter (DOC), polysaccharide, protein and humic acids, attaining removals of 64...
December 2, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27918990/effects-of-tripolyphosphate-on-cellular-uptake-and-rna-interference-efficiency-of-chitosan-based-nanoparticles-in-raw-264-7-macrophages
#4
Bo Xiao, Panpan Ma, Lijun Ma, Qiubing Chen, Xiaoying Si, Lewins Walter, Didier Merlin
Tumor necrosis factor-α (TNF-α) is a major pro-inflammatory cytokine that is mainly secreted by macrophages during inflammation. Here, we synthesized a series of N-(2-hydroxy)propyl-3-trimethyl ammonium chitosan chlorides (HTCCs), and then used a complex coacervation technique or tripolyphosphate (TPP)-assisted ionotropic gelation strategy to complex the HTCCs with TNF-α siRNA (siTNF) to form nanoparticles (NPs). The resultant NPs had a desirable particle size (210-279nm), a slightly positive zeta potential (14-22mV), and negligible cytotoxicity against Raw 264...
November 26, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27918986/hybrid-chitosan-polyaniline-polypyrrole-biomaterial-for-enhanced-adsorption-and-antimicrobial-activity
#5
Rajeev Kumar, Mohammad Oves, Talla Ameelbi, Naief H Al-Makishah, M A Barakat
In this work, chitosan (CS) functionalized polyaniline-polypyrrole (Pani-Ppy) copolymer (CS/Pani-Ppy) was synthesized applying a facile one pot method for the enhanced adsorption of Zn(II) and antimicrobial activity for E. coli and E. agglomerans. The synthesized materials were characterized using scanning electron microscopy, energy dispersive X-ray spectroscopy, Fourier transform inferred spectroscopy and X-ray photoelectron spectroscopy. The adsorption of the Zn(II) on the synthesized materials was highly dependent on the pH of the solution, the initial metal ion concentration, and temperature...
November 24, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27918923/adsorption-of-valuable-metals-from-leachates-of-mobile-phone-wastes-using-biopolymers-and-activated-carbon
#6
Maria A Zazycki, Eduardo H Tanabe, Daniel A Bertuol, Guilherme L Dotto
In this work, chitin (CTN), chitosan (CTS) and activated carbon (AC) were used as adsorbents to recover valuable metals from leachates of mobile phone wastes. The mobile phone wastes (contactors) were collected and characterized. The valuable metals were extracted by thiourea leaching. The adsorption of valuable metals from leachates was studied according to the kinetic and equilibrium viewpoints. It was found that the contactors were composed by Au, Ni, Cu and Sn. The thiourea leaching provided extraction percentages of 68...
December 2, 2016: Journal of Environmental Management
https://www.readbyqxmd.com/read/27918250/evaluation-of-immunostimulatory-effects-of-n-2-hydroxy-propyl-3-trimethylammonium-chitosan-chloride-for-improving-live-attenuated-hepatitis-a-virus-vaccine-efficacy
#7
Wei Tao, Ting Fu, Zhuojing He, Ruxi Hu, Lan Jia, Yan Hong
This study was to evaluate the immunostimulatory effects of N-(2-hydroxy) propyl-3-trimethylammonium chitosan chloride (HTCC) as an adjuvant for improving a commercial live attenuated hepatitis A virus (HAV) vaccine efficacy in mice. Mice in the experimental group were intraperitoneally immunized with a solution of HTCC and live attenuated HAV vaccine. And for those injected with sterile water, HTCC or live attenuated HAV vaccine were treated as mock group, negative group, and positive group in turn. The serum HAV-specific IgG titers and the ratios of the serum HAV-specific IgG2a/IgG1 in the experimental group were significantly increased (p = 0...
December 5, 2016: Viral Immunology
https://www.readbyqxmd.com/read/27917871/delivery-of-acetylthevetin-b-an-antitumor-cardiac-glycoside-using-polymeric-micelles-for-enhanced-therapeutic-efficacy-against-lung-cancer-cells
#8
Jing-Jing Zhu, Xin-Xin Zhang, Yun-Qiu Miao, Shu-Fang He, Dan-Mei Tian, Xin-Sheng Yao, Jin-Shan Tang, Yong Gan
Acetylthevetin B (ATB), a cardiac glycoside from the seed of Thevetia peruviana (Pers) K Schum (yellow oleander), exhibits not only antitumor activity but also potential cardiac toxicity. In the present study, we attempted to enhance its antitumor action and decrease its adverse effects via chitosan-Pluronic P123 (CP) micelle encapsulation. Two ATB-loaded CP micelles (ATB-CP1, ATB-CP2) were prepared using an emulsion/solvent evaporation technique. They were spherical in shape with a particle size of 40-50 nm, showed a neutral zeta potential, and had acceptable encapsulation efficiency (>90%)...
December 5, 2016: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/27917819/pulsatile-flow-conditioning-of-three-dimensional-bioengineered-cardiac-ventricle
#9
Nikita M Patel, Ravi K Birla
Current physical stimuli mechanical stretch bioreactor studies focus on conditioning planar and/or tubular engineered cardiac constructs. The current 3D bioreactor models in cardiac tissue engineering use differential pressure loading for structural support as opposed to conditioning. The development of the pulsatile flow conditioned ventricle (PFCV) provides a 3D mechanical stretch conditioning method to generate pump function in the engineered cardiac left ventricle. The study utilizes a chitosan bioengineered open ventricle scaffold, to produce the in vitro PFCV model...
December 5, 2016: Biofabrication
https://www.readbyqxmd.com/read/27917281/gene-therapy-based-on-interleukin-12-loaded-chitosan-nanoparticles-in-a-mouse-model-of-fibrosarcoma
#10
Saiedeh Razi Soofiyani, Somayeh Hallaj-Nezhadi, Farzaneh Lotfipour, Akbar Mohammad Hosseini, Behzad Baradaran
OBJECTIVES: Interleukin-12 (IL-12) as a cytokine has been proved to have a critical role in stimulating the immune system and has been used as immunotherapeutic agents in cancer gene therapy. Chitosan as a polymer, with high ability of binding to nucleic acids is a good candidate for gene delivery since it is biodegradable, biocompatible and non-allergenic polysaccharide. The objective of the present study was to investigate the effects of cells transfected with IL-12 loaded chitosan nanoparticles on the regression of fibrosarcoma tumor cells (WEHI-164) in vivo...
November 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27916692/the-effects-of-bacteria-nanoparticles-interface-on-the-antibacterial-activity-of-green-synthesized-silver-nanoparticles
#11
Aftab Ahmad, Yun Wei, Fatima Syed, Kamran Tahir, Aziz Ur Rehman, Arifullah Khan, Sadeeq Ullah, Qipeng Yuan
Neutralization of bacterial cell surface potential using nanoscale materials is an effective strategy to alter membrane permeability, cytoplasmic leakage, and ultimate cell death. In the present study, an attempt was made to prepare biogenic silver nanoparticles using biomolecules from the aqueous rhizome extract of Coptis Chinensis. The biosynthesized silver nanoparticles were surface modified with chitosan biopolymer. The prepared silver nanoparticles and chitosan modified silver nanoparticles were cubic crystalline structures (XRD) with an average particle size of 15 and 20 nm respectively (TEM, DLS)...
December 1, 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27916629/chitosan-nanoparticles-as-a-dual-drug-sirna-delivery-system-for-treatment-of-colorectal-cancer
#12
Sanam Sadreddini, Reza Safaralizadeh, Behzad Baradaran, Leili Aghebati-Maleki, Mohammad Ali Hosseinpour-Feizi, Dariush Shanehbandi, Farhad Jadidi-Niaragh, Sevil Sadreddini, Hossein Samadi Kafil, Vahid Younesi, Mehdi Yousefi
Nanoparticles are widely used to deliver anticancer drugs and inhibit tumor growth without systemic toxicity. Recently, chitosan has received much attention as a functional biopolymer for encapsulation of small interfering RNA (siRNA). Because of cationic nature, chitosan efficiently encapsulate siRNA and forming nanoparticles. Moreover, biocompatible and biodegradable properties represent chitosan as potential candidate for in vivo siRNA delivery. In the present study we designed carboxymethyl dextran (CMD) chitosan nanoparticles (ChNPs) to encapsulat snail siRNA and anticancer drug doxorubicin (DOX)...
December 1, 2016: Immunology Letters
https://www.readbyqxmd.com/read/27915018/design-and-surface-immobilization-of-short-anti-biofilm-peptides
#13
Biswajit Mishra, Tamara Lushnikova, Radha M Golla, Xiuqing Wang, Guangshun Wang
: Short antimicrobial peptides are essential to keep us healthy and their lasting potency can inspire the design of new types of antibiotics. This study reports the design of a family of eight-residue tryptophan-rich peptides (TetraF2W) obtained by converting the four phenylalanines in temporin-SHf to tryptophans. The temporin-SHf template was identified from the antimicrobial peptide database (http://aps.unmc.edu/AP). Remarkably, the double arginine variant (TetraF2W-RR) was more effective in killing methicillin-resistant Staphylococcus aureus (MRSA) USA300, but less cytotoxic to human skin HaCat and kidney HEK293 cells, than the lysine-containing dibasic combinations (KR, RK and KK)...
November 30, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27914966/cross-linked-chitosan-thin-film-coated-onto-glass-plate-as-an-effective-adsorbent-for-adsorption-of-reactive-orange-16
#14
Ali H Jawad, M Azharul, B H Hameed
Fabrication of an immobilized cross-linked chitosan-epichlorohydrine thin film (CLCETF) onto glass plate for adsorption of reactive orange 16 (RO16) dye was successfully studied using the direct casting technique. Adsorption experiments were performed as a function of contact time, initial dye concentration (25mg/L to 350mg/L), and pH (3 to 11). The adsorption isotherm followed the Langmuir model. The adsorption capacity of CLECTF for RO16 was 356.50mg/g at 27±2°C. The kinetics closely followed the pseudo-second-order model...
November 30, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27914250/chitosan-nanoparticles-as-carrier-systems-for-the-plant-growth-hormone-gibberellic-acid
#15
Anderson Espirito Santo Pereira, Paula Mayara Silva, Jhones Luis Oliveira, Halley Caixeta Oliveira, Leonardo Fernandes Fraceto
This work concerns the development of nanocarriers composed of alginate/chitosan (ALG/CS) and chitosan/tripolyphosphate (CS/TPP) for the plant growth regulator gibberellic acid (GA3). ALG/CS nanoparticles with and without GA3 presented mean size of 450±10nm, polydispersity index (PDI) of 0.3, zeta potential of -29±0.5mV, concentrations of 1.52×10(11) and 1.92×10(11) nanoparticles mL(-1), respectively, and 100% encapsulation efficiency. CS/TPP nanoparticles with and without GA3 presented mean size of 195±1nm, PDI of 0...
November 23, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27912130/acidity-triggered-charge-convertible-nanoparticles-that-can-cause-bacterium-specific-aggregation-in-situ-to-enhance-photothermal-ablation-of-focal-infection
#16
Chiranjeevi Korupalli, Chieh-Cheng Huang, Wei-Chih Lin, Wen-Yu Pan, Po-Yen Lin, Wei-Lin Wan, Meng-Ju Li, Yen Chang, Hsing-Wen Sung
Focal infections that are caused by antibiotic-resistant bacteria are becoming an ever-growing challenge to human health. To address this challenge, a pH-responsive amphiphilic polymer of polyaniline-conjugated glycol chitosan (PANI-GCS) that can self-assemble into nanoparticles (NPs) in situ is developed. The PANI-GCS NPs undergo a unique surface charge conversion that is induced by their local pH, favoring bacterium-specific aggregation without direct contact with host cells. Following conjugation onto GCS, the optical-absorbance peak of PANI is red-shifted toward the near-infrared (NIR) region, enabling PANI-GCS NPs to generate a substantial amount of heat, which is emitted to their neighborhood...
November 24, 2016: Biomaterials
https://www.readbyqxmd.com/read/27912122/ring-like-structured-chitosan-metal-hydrogel-mass-production-formation-mechanism-and-applications
#17
Hao Zhou, LiLi Xu, Yuezhong Wen, Kunde Lin, Xiaomei Zeng
To improve the solid/liquid separation of chitosan adsorbents as well as the adsorption ability, chitosan was molded in several shapes. However, the ring-like structures of chitosan which have relatively larger surface area and higher chemical accessibility, but low-pressure drops than their plate-like counterparts has not been reported. In this study, we put forward a novel concept to fabricate a kind of highly efficient ring-like structured chitosan hydrogel through a sulfate ionic crosslinking method, its mass production and formation mechanism has been fully proposed...
November 21, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27910984/enzyme-immobilized-clay-nanotube-chitosan-membranes-with-sustainable-biocatalytic-activities
#18
Jiajia Sun, Raghuvara Yendluri, Kai Liu, Ying Guo, Yuri Lvov, Xuehai Yan
We have developed a simple and effective strategy to prepare an enzymatic membrane by the admixing of a halloysite clay nanotube-lipase complex and a chitosan solution. The loading of 3 wt% lipase into the lumen of halloysite clay nanotubes was enhanced with an electrostatic interaction. 10 wt% of lipase-nanotubes were dispersed in an aqueous chitosan solution and cast as a coating. The enzymatic chitosan-halloysite membranes displayed increased pH, temperature stability and long-term usability for the catalytic decomposition of lipids: 90% of the initial activity was preserved at 80 °C, 70% of the functionality remained at the high pH of 9, and 85% of the activity was sustained after ten continuous cycles of use...
December 2, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27910914/in-vivo-stepwise-immunomodulation-using-chitosan-nanoparticles-as-a-platform-nanotechnology-for-cancer-immunotherapy
#19
Hee Dong Han, Yeongseon Byeon, Jong-Hwa Jang, Hat Nim Jeon, Ga Hee Kim, Min Gi Kim, Chan-Gi Pack, Tae Heung Kang, In Duk Jung, Yong Taik Lim, Young Joo Lee, Jeong-Won Lee, Byung Cheol Shin, Hyung Jun Ahn, Anil K Sood, Yeong-Min Park
Dentritic cell (DC)-based cancer immunotherapy faces challenges in both efficacy and practicality. However, DC-based vaccination requires multiple injections and elaborates ex vivo manipulation, which substantially limits their use. Therefore, we sought to develop a chitosan nanoparticle (CH-NP)-based platform for the next generation of vaccines to bypass the ex vivo manipulation and induce immune responses via active delivery of polyinosinic-polycytidylic acid sodium salt (poly I:C) to target Toll-like receptor 3 (TLR3) in endosomes...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27910815/in-vitro-and-in-vivo-evaluations-of-a-novel-post-electrospinning-treatment-to-improve-the-fibrous-structure-of-chitosan-membranes-for-guided-bone-regeneration
#20
Hengjie Su, Kwei-Yu Liu, Anastasios Karydis, Daniel G Abebe, Chaoxi Wu, Kenneth M Anderson, Najib Ghadri, Pradeep Adatrow, Tomoko Fujiwara, Joel D Bumgardner
Electrospun chitosan membranes have been investigated for guided bone regeneration but are susceptible to swelling, dissolution, and loss of biomimetic nanofiber structure due to residual acid salts. A novel process was investigated for acidic salt removal from chitosan electrospun in 70% trifluoroacetic acid (TFA) by treating with triethylamine (TEA)/acetone and di-tert-butyl dicarbonate (tBOC) instead of the common Na2CO3 treatment. TFA salt removal and nanofiber structure stabilization were confirmed by EDS, FTIR, (19)F NMR and electron microscopy before and after soaking in water...
December 2, 2016: Biomedical Materials
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