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https://www.readbyqxmd.com/read/28532111/surface-biofunctionalization-of-three-dimensional-porous-poly-lactic-acid-scaffold-using-chitosan-ogp-coating-for-bone-tissue-engineering
#1
Sen Zeng, Jianhua Ye, Zhixiang Cui, Junhui Si, Qianting Wang, Xiaofeng Wang, Kaiping Peng, Wenzhe Chen
As one of the stimulators on bone formation, osteogenic growth peptide (OGP) improves both proliferation and differentiation of the bone cells in vitro and in vivo. The aim of this work was the preparation of three dimensional porous poly(lactic acid) (PLA) scaffold with high porosity from PLA-dioxane-water ternary system with the use of vacuum-assisted solvent casting, phase separation, solvent extraction and particle leaching methods. Then, by surface coating of PLA scaffold with chitosan (CS)/OGP solution, biofunctionalization of PLA scaffold had been completed for application in bone regeneration...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532076/sustained-drug-release-from-surface-modified-uhmwpe-for-acetabular-cup-lining-in-total-hip-implant
#2
R Manoj Kumar, Pallavi Gupta, Sandan Kumar Sharma, Akshat Mittal, Manish Shekhar, Vijayesh Kumar, B V Manoj Kumar, Partha Roy, Debrupa Lahiri
Despite sterilization and aseptic procedure, bacterial infection remains a key challenge in total hip arthroplasties. This fact emphasizes the urgent need for development of new implant systems, which should releases the drug in a controlled manner without sparing its mechanical and tribological properties. In this study, the lining material of the acetabular cup, in total hip implant, has been modified for sustained release of drugs, which should be available throughout the site of implantation to fight the post-operation bacterial infection...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532069/photothermal-conversion-efficiency-and-cytotoxic-effect-of-gold-nanorods-stabilized-with-chitosan-alginate-and-poly-vinyl-alcohol
#3
M Almada, B H Leal-Martínez, N Hassan, M J Kogan, M G Burboa, A Topete, M A Valdez, J Juárez
Gold nanorods (GNR) use has been proposed in medical applications because of their intrinsic photothermal properties. However, the presence of CTAB molecules adsorbed onto the surface of GNRs results in a highly cytotoxic GNR system. In this work we replace the CTAB molecules with a thiolated chitosan. Once chitosan coated GNRs (Chi-SH-GNR) were attained, a film of alginate (Alg-Chi-SH-GNR) or polyvinyl alcohol (PVA-Chi-SH-GNR) was deposited onto the surface of Chi-GNR by a layer-by-layer process. The photothermal conversion efficiency for the GNR systems was determined irradiating the GNRs suspended in aqua media with a CW 808nm diode laser (CNI, China)...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532051/chitosan-folate-decorated-carbon-nanotubes-for-site-specific-lung-cancer-delivery
#4
Rahul Pratap Singh, Gunjan Sharma, Sonali, Sanjay Singh, Shreekant Bharti, Bajarangprasad L Pandey, Biplob Koch, Madaswamy S Muthu
The aim of this work was to formulate chitosan-folate conjugated multi-walled carbon nanotubes for the lung cancer targeted delivery of docetaxel. The chitosan-folate conjugate was synthesized and the conjugation was confirmed by Fourier transform infrared spectroscopy. The multi-walled carbon nanotubes were characterized for their particle size, polydispersity, zeta potential, surface morphology, drug encapsulation efficiency and in vitro release study. The in vitro cellular uptake, cytotoxicity, and cell cycle analysis of the docetaxel/coumarin-6 loaded multi-walled carbon nanotubes were carried out to compare the effectiveness of the formulations...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532047/porous-chitosan-microspheres-for-application-as-quick-in-vitro-and-in-vivo-hemostat
#5
Jixiang Li, Xiaowei Wu, Yanqing Wu, Zonghao Tang, Xun Sun, Meng Pan, Yufeng Chen, Juanjuan Li, Rongdong Xiao, Zhengchao Wang, Haiqing Liu
Controlling massive hemorrhage is of great importance to lower transfusional medical cost, and to reduce death and mobility rate in battlefield and civilian accidents. We reported the fabrication of porous chitosan microspheres (CSMS) with tunable surface pore size by microemulsion combined with thermally induced phase separation technique, and its application as a quick hemostat. Their hemostatic property was characterized by blood clotting kinetics, adherence interaction between red blood cells/platelets and CSMS, in vitro and in vivo hemostasis by rat tail amputation and liver laceration models, and histological analysis...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532030/tetracycline-hydrochloride-loaded-electrospun-nanofibers-mats-based-on-pva-and-chitosan-for-wound-dressing
#6
Alex Carvalho Alavarse, Fernanda Waitman de Oliveira Silva, Jandir Telleria Colque, Viviam Moura da Silva, Tatiane Prieto, Everaldo Carlos Venancio, Jean-Jacques Bonvent
Fibrous mats built from biopolymer have been extensively explored for tissue engineering due mainly to their mimic structure to the extracellular matrix. The incorporation of drug in such scaffolds represents a growing interest for control drug delivery system in order to promote the tissue repair. In the present work, we present an experimental investigation of morphological, thermal, mechanical, drug release, antibacterial and cytotoxicity properties of electrospun PVA/Chitosan and PVA/Chitosan/Tetracycline hydrochloride (TCH) mats for wound dressing...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532022/a-novel-grapheme-oxide-modified-collagen-chitosan-bio-film-for-controlled-growth-factor-release-in-wound-healing-applications
#7
Ting Liu, Weihua Dan, Nianhua Dan, Xinhua Liu, Xuexu Liu, Xu Peng
Collagen-chitosan composite film modified with grapheme oxide (GO) and 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC), termed CC-G-E film, was loaded with basic fibroblast growth factor (bFGF) as the development of an efficacious wound healing device. In this study we report a novel drug delivery system that prevents the initial burst release and loss of bioactivity of drugs in vitro and in vivo applications. The results showed that CC-G-E film possessed improved thermal stability and a higher rate of crosslinking with increased mechanical properties when the dosage of GO was between 0...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532021/nanosecond-laser-ablation-enhances-cellular-infiltration-in-a-hybrid-tissue-scaffold
#8
S Jahnavi, N Arthi, S Pallavi, C Selvaraju, G S Bhuvaneshwar, T V Kumary, R S Verma
Hybrid tissue engineered (HTE) scaffolds constituting polymeric nanofibers and biological tissues have attractive bio-mechanical properties. However, they suffer from small pore size due to dense overlapping nanofibers resulting in poor cellular infiltration. In this study, using nanosecond (ns) laser, we fabricated micro-scale features on Polycaprolactone (PCL)-Chitosan (CH) nanofiber layered bovine pericardium based Bio-Hybrid scaffold to achieve enhanced cellular adhesion and infiltration. The laser energy parameters such as fluence of 25J/cm(2), 0...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532012/an-overview-of-carboxymethyl-derivatives-of-chitosan-their-use-as-biomaterials-and-drug-delivery-systems
#9
REVIEW
Bruno Fonseca-Santos, Marlus Chorilli
Chitin is one of the most abundant natural polymers in the world and is used for the production of chitosan by deacetylation. Chitosan is nontoxic and biodegradable and, therefore, can be used as a biomaterial and for the construction of drug delivery systems. Nevertheless, the poor solubility of chitosan in neutral or alkalinized media has restricted its applications in the pharmaceutical and biomedical fields. Chitosan can be easily carboxymethylated to improve its solubility in aqueous media while its biodegradability and biocompatibility are preserved...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532002/electrochemical-sensor-for-detection-of-hydrogen-peroxide-modified-with-prussian-blue-electrodeposition-on-nitrogen-phosphorus-and-sulfur-co-doped-porous-carbons-chitosan
#10
Xiurong Zhai, Yonghong Li, Jisen Li, Chengyang Yue, Xiaowu Lei
Nitrogen, phosphorus and sulfur co-doped porous carbons (N, P, S@PC) were well dispersed in the chitosan (CS) acid solution, in particular via covalently interaction, which could avoid the aggregation of N, P, S@PC in most solvents. Moreover, CS could also avoid N, P, S@PC leakage from the modified electrode. A novel electrochemical sensor was then developed through prussian blue (PB) was electrodeposited on the glass carbon (GC) electrode modified with N, P, S@PC-CS composite. Results with scanning electron microscopy image, illustrate that PB/N, P, S@PC-CS composite distributes very uniformly on the substrate surface, which is hoped to be very attractive for determination of hydrogen peroxide (H2O2)...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531995/scavenging-free-radicals-and-soaring-osteoinduction-by-extra-cellular-matrix-protein-based-nanocomposites-on-degenerative-bone-treatments
#11
Kavitha Kandiah, Navaneethan Duraisamy, Vinoth Amirthalingam, Balagurunathan Ramasamy
A number of materials are now available to alleviate the ever-growing bone disruption. However, these are inadequate and inappropriate for addressing issues associated natural process of aging and degeneration of bone due to diseases. This study advances the existing material and offers more privileged and synergistically active remedy for these conditions. Here, they are three different nano-composites prepared such as nano-TiO2 with chitosan (TC), nano-TiO2 with chondroitin 4-sulfate (TG), and nano-TiO2 with chitosan and chondroitin 4-sulfate (TCG), whereas nano-TiO2 act as a control...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531994/a-facile-one-step-method-for-preparation-of-fe3o4-cs-inh-nanoparticles-as-a-targeted-drug-delivery-for-tuberculosis
#12
Chili Zhao, Xun Liu, Xia Zhang, Hong Yan, Zhilei Qian, Xinghui Li, Zhenye Ma, Qiaorong Han, Chonghua Pei
In this paper, Fe3O4/chitosan/isoniazid magnetic nanoparticles (Fe3O4/CS/INH-MNPs) were prepared as an environmental stimuli-responsive drug-delivery system by automated in situ click technology, in which Fe3O4 magnetic nanoparticles, chitosan and isoniazid were simultaneously in situ crystallized by one-step method. The Fe3O4 magnetic nanoparticles and tripolyphosphate act as stable crosslinkers to produce numerous intermolecular crosslinkages for the mobility of the chitosan chains. Characterization results indicated that the multifunctional drug delivery system with optimized size, excellent loading capacity, well magnetic properties, nontoxicity and pH triggered drug release property is expected to be applied in tuberculosis treatment with excellent magnetic sensitivity and sustained release...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531991/multifunctional-polymer-drug-loading-system-with-ph-sensitive-fluorescent-and-targeting-property
#13
Xuening Fei, Shubei Li, Lingyun Cao, Baolian Zhang, Miaozhuo Yu
IA multifunctional drug loading system with pH-sensitive, fluorescent and targeting property was fabricated. Firstly, the amphipathic N-octyl-N'-(2-carboxyl-cyclohexamethenyl) chitosan (OCCC) was prepared by grafting hydrophobic octyl group and hydrophilic hexahydrophthalic anhydride onto chitosan, then it was modified with folic acid (FA) and thiazole orange (TO) using polyethylene glycol (PEG) as the link to fabricate a multifunctional drug loading system TO-PEG-OCCC-PEG-FA. Its chemical structure was determined by Fourier transform infrared spectroscopy (FT-IR), elemental analysis, differential scanning calorimetry (DSC) analysis, UV-vis and fluorescence spectrometer, and the results showed that the substitution degree of hydrophobic/hydrophilic group onto chitosan were 41...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531980/self-assembled-nanomicelles-of-damnacanthal-loaded-amphiphilic-modified-chitosan-preparation-characterization-and-cytotoxicity-study
#14
Pakin Sukamporn, Seung Joon Baek, Wandee Gritsanapan, Suwabun Chirachanchai, Thararat Nualsanit, Pleumchitt Rojanapanthu
Damnacanthal (Dam) is a phytochemical with many pharmacological properties including anticancer activity. However, its hydrophobicity, poor bioavailability and stability limit its application in many biological approaches. In this study, Dam nanomicelles as an emerging platform were developed to overcome limitations. The deoxycholic and poly(ethylene glycol) methyl ether grafted chitosan (DCA-CS-mPEG) was synthesized and characterized by FTIR and (1)H NMR and the degree of substitution (DS) was determined by elemental analysis (EA)...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531847/colorimetric-detection-of-biothiols-based-on-aggregation-of-chitosan-stabilized-silver-nanoparticles
#15
Somayeh Mohammadi, Gholamreza Khayatian
We have described a simple and reliable colorimetric method for the sensing of biothiols such as cysteine, homocysteine, and glutathione in biological samples. The selective binding of chitosan capped silver nanoparticles to biothiols induced aggregation of the chitosan-Ag NPs. But the other amino acids that do not have thiol group cannot aggregate the chitosan-Ag NPs. Aggregation of chitosan-Ag NPs has been confirmed with UV-vis absorption spectra, zeta potential and transmission electron microscopy images...
May 17, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28531662/microencapsulation-of-gulosibacter-molinativorax-on4-t-cells-by-a-spray-drying-process-using-different-biopolymers
#16
Berta N Estevinho, A Rita Lopes, Vera Sousa, Fernando Rocha, Olga C Nunes
Molinate is a thiocarbamate herbicide used in rice crop protection. As other pesticides, molinate is a recognized environmental pollutant and bio-accumulated by some wildlife forms. Gulosibacter molinativorax ON4(T) is able to hydrolyse molinate into metabolites which are further degraded by other un-related bacteria. Hence, it can be used in molinate bioremediation processes. The aim of this work was to investigate the possibility of producing G. molinativorax ON4(T) microparticles, using different non-toxic biopolymers (arabic gum, modified chitosan, calcium alginate and sodium alginate) as encapsulating agents by a spray-drying process...
May 11, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28530300/physicochemical-and-antimicrobial-properties-of-%C3%AE%C2%B5-polylysine-carboxymethyl-chitosan-polyelectrolyte-complexes-and-their-effect-against-spoilage-microorganisms-in-raw-pork
#17
Liang Guo, Yuecheng Meng, Sheng Fang
This study investigated the properties of polyelectrolyte complexes (PECs) fabricated by using ε-polylysine (EPL) and N,O-carboxymethyl chitosan (NOCC) and their potential applications in raw pork. The phase behaviors of PECs in aqueous solutions are characterized by the ζ-potential, mean radius and turbidimetric measurements. Stable colloidal and soluble PEC systems can be fabricated by carefully adjusting the mass ratio of NOCC to EPL. The minimum inhibitory concentration (MIC) assay showed that the colloidal and soluble PECs could maintain the antimicrobial activity of EPL in a laboratory medium...
May 22, 2017: Food & Function
https://www.readbyqxmd.com/read/28530193/surface-adsorption-of-poisonous-pb-ii-ions-from-water-using-chitosan-functionalised-magnetic-nanoparticles
#18
Femina Carolin Christopher, Saravanan Anbalagan, Ponnusamy Senthil Kumar, Sundar Rajan Pannerselvam, Vinoth Kumar Vaidyanathan
In this study, chitosan functionalised magnetic nano-particles (CMNP) was synthesised and utilised as an effective adsorbent for the removal of Pb(II) ions from aqueous solution. The experimental studies reveal that adsorbent material has finer adsorption capacity for the removal of heavy metal ions. Parameters affecting the adsorption of Pb(II) ions on CMNP, such as initial Pb(II) ion concentration, contact time, solution pH, adsorbent dosage and temperature were studied. The adsorption equilibrium study showed that present adsorption system followed a Freundlich isotherm model...
June 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/28530192/preparation-structural-characterisation-and-release-study-of-novel-hybrid-microspheres-entrapping-nanoselenium-produced-by-green-synthesis
#19
Simona Cavalu, Jόszef Prokisch, Vasile Laslo, Simona Vicas
The main goal of this study was to synthesise and characterise different formulations based on alginate and alginate/chitosan microspheres containing nanoselenium (nano-Se) for controlled delivery applications. Nanosize elemental selenium was produced by using probiotic yogurt bacteria (Lactobacillus casei) in a fermentation procedure. The structural and morphological characterisation of the microspheres was performed by Fourier transform infrared (FTIR), X-ray diffraction (XRD) and scanning electron microscopy (SEM) analysis...
June 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/28529754/chitosan-poly-caprolactone-nanofibers-for-skin-repair
#20
Sheeny Lan Levengood, Ariane E Erickson, Fei-Chien Chang, Miqin Zhang
Dermal wounds, both acute and chronic, represent a significant clinical challenge and therefore the development of novel biomaterial-based skin substitutes to promote skin repair is essential. Nanofibers have garnered attention as materials to promote skin regeneration due to the similarities in morphology and dimensionality between nanofibers and native extracellular matrix proteins, which are critical in guiding cutaneous wound healing. Electrospun chitosan-poly(caprolactone) (CPCL) nanofiber scaffolds, which combine the important intrinsic biological properties of chitosan and the mechanical integrity and stability of PCL, were evaluated as skin tissue engineering scaffolds using a mouse cutaneous excisional skin defect model...
March 7, 2017: Journal of Materials Chemistry. B, Materials for Biology and Medicine
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