keyword
MENU ▼
Read by QxMD icon Read
search

Chitosan

keyword
https://www.readbyqxmd.com/read/29231215/involvement-of-fak-mediated-bmp-2-smad-pathway-in-mediating-osteoblast-adhesion-and-differentiation-on-nano-ha-chitosan-composite-coated-titanium-implant-under-diabetic-conditions
#1
Xiang-Yu Ma, Ya-Fei Feng, Tian-Sheng Wang, Wei Lei, Xiang Li, Da-Peng Zhou, Xin-Xin Wen, Hai-Long Yu, Liang-Bi Xiang, Lin Wang
Chitosan (CS)-based hydroxyapatite (HA) composites have emerged as a novel strategy for promoting bone regeneration. Here nanophase HA/CS composite coated porous titanium implants (nCT) were fabricated and their biological behavior under diabetic conditions was investigated. We proposed that the focal adhesion kinase (FAK)-mediated BMP-2/Smad pathway played a role in mediating the promotive effect of nCTs on osteoblast adhesion and differentiation under diabetes-induced high reactive oxygen species (ROS) condition...
December 12, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/29230255/control-of-cell-proliferation-by-a-porous-chitosan-scaffold-with-multiple-releasing-capabilities
#2
Shu-Jyun Cai, Ching-Wen Li, Daphne Weihs, Gou-Jen Wang
The aim of this study was to develop a porous chitosan scaffold with long-acting drug release as an artificial dressing to promote skin wound healing. The dressing was fabricated by pre-freezing at different temperatures (-20 and -80 °C) for different periods of time, followed by freeze-drying to form porous chitosan scaffolds with different pore sizes. The chitosan scaffolds were then used to investigate the effect of the controlled release of fibroblast growth factor-basic (bFGF) and transforming growth factor-β1 (TGFβ1) on mouse fibroblast cells (L929) and bovine carotid endothelial cells (BEC)...
2017: Science and Technology of Advanced Materials
https://www.readbyqxmd.com/read/29229504/an-inhibitory-action-of-chitosan-nanoparticles-against-pathogenic-bacteria-and-fungi-and-their-potential-applications-as-biocompatible-antioxidants
#3
D MubarakAli, F LewisOscar, V Gopinath, Naify S Alharbi, Sulaiman Ali Alharbi, N Thajuddin
Chitosan is the second most abundant polymer obtained from the byproduct of seafood. Chitosan and its derivatives and chitosan loaded drugs are the recent area of interest against microbial pathogenesis. The cationic chitosan nanoparticles (ChNPs) interact with the anionic surfaces of the microbial cell membrane, which promotes antimicrobial activity. Although, ChNPs are potential against pathogenic microbes, selection of adaptable, suitable and cost effective synthesis method is much important. In the present study, ChNPs were synthesized adopting ionic gelation using sodium tripolyphosphate as a cross linking agent and characterized by FTIR, DLS, SEM and TEM analysis...
December 8, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29229243/nano-composites-chitosan-curcumin-synergistically-inhibits-the-oxidative-stress-induced-by-toxic-metal-cadmium
#4
Mohammad Ahmad, Gasem M Abu Taweel, Syed Hidayathulla
The present study intends to compare the influence of pre-treatment with nanoparticles of curcumin (Cr-NPS), chitosan (Ch-NPS) and nanocomposites chitosan-curcumin (CC-NPS) on cadmium (Cd)-induced oxidative damage in the liver, kidneys, and blood indices in Swiss strain adult male mice. The pretreated mice with Cr-NPS, Ch-NPS, and CC-NPS were exposed to Cd (10mg/kg) for three weeks. The non-enzymatic Oxidative Stress (OS) indices like lipid peroxides (TBARS), reduced total glutathione (GSH), enzymatic OS indices like catalase (CAT), glutathione S-transferase (GST) and superoxide dismutase (SOD) were estimated together with some blood indices...
December 8, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29229242/synthesis-characterisation-and-biomedical-applications-of-curcumin-conjugated-chitosan-microspheres
#5
T S Saranya, V K Rajan, Raja Biswas, R Jayakumar, S Sathianarayanan
Curcumin is a diaryl heptanoid of curcuminoids class obtained from Curcuma longa. It possesses various biological activities like anti-inflammatory, hypoglycemic, antioxidant, wound-healing, and antimicrobial activities. Chitosan is a biocompatible, biodegradable and non-toxic natural polymer which enhances the adhesive property of the skin. Chemical conjugation will leads to sustained release action and to enhance the bioavailability. This study aims to synthesis and characterize biocompatible curcumin conjugated chitosan microspheres for bio-medical applications...
December 8, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29229241/intelligent-poly-vinyl-alcohol-chitosan-nanoparticles-mulberry-extracts-films-capable-of-monitoring-ph-variations
#6
Qianyun Ma, Tieqiang Liang, Lele Cao, Lijuan Wang
The aim of this study was to prepare a visually responsive intelligent film based on poly (vinyl alcohol) (PVA), chitosan nanoparticles (CHNPs) and mulberry extracts (MBE). CHNPs were first prepared by using ionotropic gelation method to enhance the mechanical properties of PVA based films. The morphology, particle size, zeta potential and crystallinity of CHNPs were measured. The resultant CHNPs were spherical with a diameter of 381.2nm, with high stability and a zeta potential of 49.1±1.33mV. The film with 6% CHNPs (P-C6) had the highest tensile strength (∼73...
December 8, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29228693/bone-marrow-stem-cells-derived-extracellular-matrix-is-a-promising-material
#7
Xiaoyan Wang, Guanghua Chen, Chao Huang, Hualei Tu, Jilong Zou, Jinglong Yan
The extracellular matrix(ECM), which is primarily composed of collagens and proteoglycans, plays a key role in cell proliferation, differentiation, and migration and interactions between cells. In this study, we produced chitosan/gelatin/bone marrow stem cells-derived extracellular matrix(C/G/BMSCs-dECM) scaffolds via lyophilization and cross-linking, and chitosan/gelatin(C/G) scaffolds were used as controls. For the C/G/BMSCs-dECM scaffolds, the average pore size was 289.17 ± 80.28 μm; the average porosity was 89...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29227543/edible-coating-using-a-chitosan-based-colloid-incorporating-grapefruit-seed-extract-for-cherry-tomato-safety-and-preservation
#8
Jin Sung Won, Seung Jo Lee, Hyeon Hwa Park, Kyung Bin Song, Sea C Min
Grapefruit seed extract (GSE)-containing chitosan-based coating was developed and applied to cherry tomatoes to protect them from Salmonella invasion and improve their storability. The coating colloids were produced by mixing a chitosan colloid (1% [w/w] chitosan) with GSE at various concentrations (0.5%, 0.7%, 1.0%, and 1.2% [w/w]) using high-shear mixing (10000 rpm, 2 min). Coatings with chitosan colloids containing GSE at 0.0%, 0.5%, 0.7%, and 1.0% (w/w) inactivated Salmonella on cherry tomatoes by 1.0 ± 0...
December 11, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/29225179/synthesis-of-novel-benzodioxane-midst-piperazine-moiety-decorated-chitosan-silver-nanoparticle-against-biohazard-pathogens-and-as-potential-anti-inflammatory-candidate-a-molecular-docking-studies
#9
C S Karthik, H M Manukumar, A P Ananda, S Nagashree, K P Rakesh, L Mallesha, Hua-Li Qin, S Umesha, P Mallu, N B Krishnamurthy
Nanoparticles (NPs) are currently being investigated along with the use of biodegradable polymer containing active agents in many areas of medicine for targeted applications. The present study was aimed to synthesize novel compound Benzodioxane midst piperazine (BP) and characterization of a BP decorated chitosan silver nanoparticles (BP*C@AgNPs) and shown effective against hazardous pathogens, and also having anti-inflammatory property. It was further evaluated for molecular docking proofs, and toxicity. The BP*C@AgNPs had spherical shape with size of 36...
December 7, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29225177/chitosan-based-hydrogel-assisted-spongelike-calcium-phosphate-mineralization-for-in-vitro-bsa-release
#10
Ahmed Salama
New chitosan-g- poly (3-sulfopropyl methacrylate), CHI-g-P(SPMA), hydrogel was prepared by free radical polymerization process and investigated as a template for biomimetic spongelike calcium phosphate mineralization in a solution mimicking physiological condition. Infrared spectroscopy, scanning electron microscopy, X-ray diffraction and transmission electron microscopy confirmed the predominant formation of rod-like hydroxyapatite. The swelling behavior of the nanocomposite was evaluated at different pHs and different saline concentrations...
December 7, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29225174/photopolymerized-maleilated-chitosan-methacrylated-silk-fibroin-micro-nanocomposite-hydrogels-as-potential-scaffolds-for-cartilage-tissue-engineering
#11
Yingshan Zhou, Kaili Liang, Shuyan Zhao, Can Zhang, Jun Li, Hongjun Yang, Xin Liu, Xianze Yin, Dongzhi Chen, Weilin Xu, Pu Xiao
Hydrogels composed of natural materials exhibit great application potential in artificial scaffolds for cartilage repair as they can resemble the extracellular matrices of cartilage tissues comprised of various glycosaminoglycan and collagen. Herein, the natural polymers with vinyl groups, i.e. maleilated chitosan (MCS) and methacrylated silk fibroin (MSF) micro/nanoparticles, were firstly synthesized. The chemical structures of MCS and MSF micro/nanoparticles were investigated using Fourier transform infrared (FTIR) spectroscopy, proton nuclear magnetic resonance (1H NMR) spectroscopy, and X-ray photoelectron spectroscopy (XPS)...
December 7, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29225100/controllable-encapsulation-of-%C3%AE-mangostin-with-quaternized-%C3%AE-cyclodextrin-grafted-chitosan-using-high-shear-mixing
#12
Sarunya Phunpee, Kunat Suktham, Suvimol Surassmo, Suwatchai Jarussophon, Chompoonut Rungnim, Apinan Soottitantawat, Satit Puttipipatkhachorn, Uracha Rungsardthong Ruktanonchai
In this study, the inclusion complex formation between α-mangostin and water-soluble quaternized β-CD grafted-chitosan (QCD-g-CS) was investigated. Inclusion complex formation with encapsulation efficiency (%EE) of 5, 15 and 75% can be varied using high speed homogenizer. Tuning %EE plays a role on physicochemical and biological properties of α-mangostin/QCD-g-CS complex. Molecular dynamics simulations indicate that α-mangostin is included within the hydrophobic β-CD cavity and being absorbed on the QCD-g-CS surface, with these results being confirmed by Fourier transform infrared (FTIR) spectroscopy...
December 7, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29225073/corrigendum-to-131i-labeled-chitosan-hydrogels-for-radioembolization-a-preclinical-study-in-small-animals-nucl-med-biol-52-2017-16-23
#13
Hyosook Hwang, Kwang Il Kim, JeongIl Kwon, Byoung Soo Kim, Hwan-Seok Jeong, Su Jin Jang, Phil-Sun Oh, Ho Sung Park, Seok Tae Lim, Myung-Hee Sohn, Hwan-Jeong Jeong
No abstract text is available yet for this article.
December 7, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29223753/preparation-and-characterization-of-biocomposite-film-based-on-chitosan-and-kombucha-tea-as-active-food-packaging
#14
Azam Ashrafi, Maryam Jokar, Abdorreza Mohammadi Nafchi
An active film composed of chitosan and kombucha tea (KT) was successfully prepared using the solvent casting technique. The effect of incorporation of KT at the levels 1%-3% w/w on the physical and functional properties of chitosan film was investigated. The antimicrobial activity of chitosan/KT film against Escherichia coli and Staphylococcus aureus was evaluated using agar diffusion test, and its antioxidant activity was determined using DPpH assay. The results revealed that incorporation of KT into chitosan films improved the water vapor permeability (from 256...
December 6, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29223647/tat-conjugated-chitosan-cationic-micelle-for-nuclear-targeted-drug-and-gene-co-delivery
#15
Guan-Hai Wang, Yin-Yu Cai, Ji-Kun Du, Li Li, Qin Li, Hui-Kang Yang, Jian-Tao Lin
We developed a high-efficiency nucleus-targeted co-delivery vector that delivers genes and drugs directly into the nucleus of cancer cells. The system is based on grafted poly-(N-3-carbobenzyloxy-lysine) (CPCL) with transactivator of transcription (TAT)- chitosan on the surface. It is designed to perform highly efficient nucleus- targeted gene and drug co-delivery. Confocal laser scanning microscopy (CLSM) revealed that more TAT-CPCL entered the nucleus than does CPCL alone. The TAT-modified vector serves as a gene and drug co-delivery mechanism to achieve high gene transfection efficiency, high apoptosis and low viability in HeLa cells...
December 5, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29222859/physicochemical-properties-and-cytotoxicity-of-hydrogels-based-on-beetosan%C3%A2-containing-sage-and-bee-pollen
#16
Bożena Tyliszczak, Anna Drabczyk, Sonia Kudłacik-Kramarczyk, Beata Grabowska, Magdalena Kędzierska
Currently, increasing attention is being paid to issues related to environmental protection, waste management, as well as to the development of polymers with useful properties. The research presented here involved preparation of hydrogels based on Beetosan® - a chitosan derived from the multi-stage processing of dead bees. Moreover, hydrogels were additionally modified with natural substances - i.e. bee pollen and extract of Salvia officinalis (sage) that are well known for the presence of many compounds with beneficial properties from a medical point of view...
December 10, 2017: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/29222804/preparation-and-characterization-of-biocompatible-chitosan-nanoparticles-for-targeted-brain-delivery-of-peptides
#17
Muge Yemisci, Secil Caban, Eduardo Fernandez-Megia, Yilmaz Capan, Patrick Couvreur, Turgay Dalkara
Here, we describe a nanocarrier system that can transfer chitosan nanoparticles loaded with either small peptides such as the caspase inhibitor Z-DEVD-FMK or a large peptide like basic fibroblast growth factor across the blood-brain barrier. The nanoparticles are selectively directed to the brain and are not measurably taken up by the liver and spleen. Intravital fluorescent microscopy provides an opportunity to study the penetration kinetics of nanoparticles loaded with fluorescent agents such as Nile red...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29222588/modification-of-chitosan-bead-support-materials-with-l-lysine-and-l-asparagine-for-%C3%AE-amylase-immobilization
#18
Idris Yazgan, Elizabeth G Turner, Lauren E Cronmiller, Muammer Tepe, Taylan K Ozturk, Murat Elibol
Maltose syrups have got wide-range utilizations in a variety of applications from bakery to drug-development. α-Amylases are among the most widely utilized industrial enzymes due to their high specificity in production of maltose syrup from starch. However, enzymes are not stable in ex vivo conditions towards alteration in pH, temperature, and such other parameters as high salt concentrations and impurities, where immobilization is required to advance the stability of the enzyme with which approach the requirement of isolation of the enzyme from media is eliminated as well...
December 8, 2017: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/29222020/synthesis-of-protocatechuic-acid-grafted-chitosan-copolymer-structure-characterization-and-in-vitro-neuroprotective-potential
#19
Chao Xu, Shui Guan, Bo Wang, Shuping Wang, Yuxin Wang, Changkai Sun, Xuehu Ma, Tianqing Liu
Excessive free radicals can cause oxidative damage to human tissues, which results in a variety of diseases. Therefore, the development of antioxidant materials is one of the great projects in biomedical field. In this work, antioxidant protocatechuic acid (PCA) monomers were grafted onto chitosan (CS) backbones to develop a PCA grafted chitosan (PCA-g-CS) antioxidant copolymer via the method of free radical-induced grafting reaction. The formation of covalent bonds between PCA and CS were confirmed by FTIR, 1H NMR, XRD and UV-Vis...
December 5, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29222019/a-novel-use-of-cellulose-based-filter-paper-containing-silver-nanoparticles-for-its-potential-application-as-wound-dressing-agent
#20
Adnan Haider, Sajjad Haider, Inn-Kyu Kang, Anuj Kumar, Madhusudana Rao Kummara, Tahseen Kamal, Sung Soo Han
The frequent use of antibiotics against microbial infections may lead the emergence of antibiotic resistant microbial strains. To overcome these microbial strains, we need to fabricate alternative materials which can handle them. It is for this reason, we have fabricated cellulose (CE) based filter paper (FP) composite scaffolds comprising of adsorbed chitosan (CS) and sliver (Ag) nanoparticles (NPs). The AgNPs are incorporated in the CS layer of the composite scaffold. Prior to evaluate the efficacy of the scaffolds against gram positive and gram negative bacterial strains, the scaffolds were characterized for the presence of the Ag NPs with field emission scanning electron microscope (FE-SEM), fourier transform infrared (FTIR) spectroscopy and x-ray diffractometer (XRD)...
December 5, 2017: International Journal of Biological Macromolecules
keyword
keyword
11097
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"