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Chitosan

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https://www.readbyqxmd.com/read/28433886/controlled-release-of-metformin-from-chitosan-based-nanocomposite-films-containing-mesoporous-mcm-41-nanoparticles-as-novel-drug-delivery-systems
#1
Zahra Shariatinia, Zahra Zahraee
Biocompatible nanocomposite films based on blended chitosan and poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) (BP) polymers containing metformin (MET) drug and MCM-41 or MCM-41-APS (APS=aminopropylsilane) nanoparticles (NPs) were designed and fabricated in order to prepare novel drug delivery systems which are useful for controlled drug release purposes. The total pore volume and mesopore volume of MCM-41 were measured equal to 1.08 and 1.05 cm(3)/g but those of MCM-41-APS were 0...
April 13, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28433858/reduced-graphene-oxide-chitosan-aptamer-interface-as-new-platform-for-ultrasensitive-detection-of-human-epidermal-growth-factor-receptor-2
#2
Arezoo Tabasi, Abdollah Noorbakhsh, Ensiyeh Sharifi
The present work describes an ultrasensitive electrochemical aptamer-based assay for detection of human epidermal growth factor receptor 2 protein (HER2) cancer biomarker as a model analyte. Results show that the reduced graphene oxide-chitosan (rGO-Chit) film as a suitable electrode material possesses great favorable properties including high homogeneity, good stability, large surface area and high fraction of amine groups as aptamer binding sites. Various steps of aptasensor fabrication were characterized using microscopic, energy-dispersive X-ray spectroscopy (EDAX), Fourier transform infrared (FTIR) spectroscopy and electrochemical techniques...
April 18, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28433182/vitamin-d-fortified-chitosan-films-from-mushroom-waste
#3
Cristina Bilbao-Sainz, Bor-Sen Chiou, Tina Williams, Delilah Wood, Wen-Xian Du, Ivana Sedej, Zhaojun Ban, Victor Rodov, Elena Poverenov, Yakov Vinokur, Tara McHugh
Brown mushroom (Agaricus bisporus) stalk bases from mushroom waste were treated with UV-B light to rapidly increase vitamin D2 content. Chitin was also recovered from this waste and converted into chitosan by N-deacetylation. FTIR spectra showed that the mushroom chitosan were similar to chitosan from animal sources. Chitosan films were prepared using high molecular weight (HW), low molecular weight (LW) and fungal chitosan. UV-B treated mushroom particles were also incorporated into fungal chitosan films. The fungal chitosan films showed similar density, porosity and water vapor barrier properties to the LW and HW chitosan films...
July 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28433177/kinetic-study-of-thermal-degradation-of-chitosan-as-a-function-of-deacetylation-degree
#4
M A Gámiz-González, D M Correia, S Lanceros-Mendez, V Sencadas, J L Gómez Ribelles, A Vidaurre
Thermal degradation of chitosan with varying deacetylation degree (DD) ranging between 50 and 85% was analyzed by dynamic thermogravimetric analysis at different heating rates. The present study focused on the temperature range between 500 and 800K, above water evaporation. Thermal degradation showed a main degradation stage in this temperature interval with a second stage that appeared in the weight derivative curves as a shoulder in the high temperature side of the main peak with increasing intensity as the DD decreased...
July 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28433176/novel-hydroxyethyl-chitosan-cellulose-scaffolds-with-bubble-like-porous-structure-for-bone-tissue-engineering
#5
Yaping Wang, Junmin Qian, Na Zhao, Ting Liu, Weijun Xu, Aili Suo
Hydrogels fabricated from natural polysaccharides may serve as ideal scaffolds for tissue engineering because of their similarity to the extracellular matrices. In this study, novel hydrogel scaffolds with bubble-like porous structure were prepared from hydroxyethyl chitosan (HECS) and cellulose (CEL) by a combination of chemical crosslinking, particle-leaching using silicon dioxide particles as porogen and freeze-drying method. The morphology, compression stress-strain curves, wettability, and swelling and rheological behaviors of the HECS/CEL scaffolds were characterized by SEM, mechanical test, contact angle measurement and rheometer...
July 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28433172/preparation-and-characterization-of-chitosan-derivatives-and-their-application-as-flame-retardants-in-thermoplastic-polyurethane
#6
Xiaodong Liu, Xiaoyu Gu, Jun Sun, Sheng Zhang
Our previous work has demonstrated that chitosan (CS) can be directly used as charring agents. In this paper, efforts were made to further improve the thermal stability and charring ability of CS by reacting with benzaldehyde, salicylaldehyde and hydroxybenzaldehyde respectively to obtain different CS derivatives. CS derivatives in association with ammonium polyphosphate (APP) was then introduced into thermoplastic polyurethane (TPU) to prepare flame retardant TPU composites. The sample containing 18.75% APP and 6...
July 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28433169/effectiveness-of-n-o-carboxymethyl-chitosan-on-destabilization-of-marine-diesel-diesel-and-marine-2t-oil-for-oil-spill-treatment
#7
Bhairavi Doshi, Eveliina Repo, Juha P Heiskanen, Juho Antti Sirviö, Mika Sillanpää
Oil spills are the significant sources of hydrocarbons entering in the receiving aquatic environment. An efficient method to remove hydrocarbons from water resources is adsorption. In this study, water soluble N,O-carboxymethyl chitosan (NO-CS) was synthesized by carboxymethylation of chitosan in a hydro-alcoholic medium at 50°C by chloroacetic acid. The polymer was characterized through degree of deacetylation, degree of substitution, FTIR and (1)H NMR. Effectiveness of NO-CS as an adsorbent was studied as a function of dosage, salinity and pH to destabilize the Marine diesel (Oil-1), Diesel (Oil-2) and Marine-2T oil (Oil-3) into small oil droplets of less than 100μm...
July 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28433166/chitosan-graphene-oxide-films-and-co2-dried-porous-aerogel-microspheres-interfacial-interplay-and-stability
#8
Sana Frindy, Ana Primo, Hamid Ennajih, Abou El Kacem Qaiss, Rachid Bouhfid, Mohamed Lahcini, El Mokhtar Essassi, Hermenegildo Garcia, Abdelkrim El Kadib
The intimate interplay of chitosan (CS) and graphene oxide (GO) in aqueous acidic solution has been explored to design upon casting, nanostructured "brick-and-mortar" films (CS-GO-f) and by acidic-to-basic pH inversion, porous CO2-dried aerogel microspheres (CS-GO-m). Owing to the presence of oxygenated functional groups in GO, good-quality crack-free hybrid films were obtained. Mechanical properties were improved independently of the GO content and it was found that a 20wt% loading affords hybrid film characterized with a Young modulus three times superior to that reached with the same loading of layered clay...
July 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28433160/thiolated-chitosan-micelles-highly-mucoadhesive-drug-carriers
#9
Arshad Mahmood, Melanie Lanthaler, Flavia Laffleur, Christian W Huck, Andreas Bernkop-Schnürch
Current study was aimed to generate thiolated chitosan micelles based on amphiphilic chitosan-stearic acid conjugate (CSA) and to evaluate adhesive properties on mucosal membranes. Chitosan-stearic acid-thioglycolic acid (CSA-TGA) conjugate was synthesized via stearic acid linkage to chitosan and later, thioglycolic acid was covalently attached to CSA. CSA-TGA and CSA were characterized by degree of amine substitution, thiol group determination, ATR-FTIR and cytotoxicity analysis. Micelle size was 13.40±9...
July 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28433157/enhanced-mechanical-properties-of-chitosan-nanodiamond-composites-by-improving-interphase-using-thermal-oxidation-of-nanodiamond
#10
Zahra Delavar, Akbar Shojaei
Polymer composite films based on chitosan (CS) and nanodimaond (ND) were prepared using solution casting method. ND with variable contents of carboxylic functional group was prepared using thermal oxidation at temperature of 420°C under air atmosphere at various durations of 1.5 and 4.5h. The interfacial interaction between NDs and CS and morphological evolution of CS in presence of NDs were investigated by Fourier transform infrared (FTIR), differential scanning calorimeter (DSC) and X-ray diffraction (XRD) analyses...
July 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28433154/non-immunogenic-porous-and-antibacterial-chitosan-and-antheraea-mylitta-silk-sericin-hydrogels-as-potential-dermal-substitute
#11
Sunaina Sapru, Ananta K Ghosh, Subhas C Kundu
Limitation of existing grafts including restricted donor site, risks of immune reactions, infectious diseases and high cost alarms the growing need of natural, cost effective and functional graft as the dermal substitute. We fabricate stable (>6 weeks) and porous (57.23-75.22μm) yet flexible (in variable pH) matrices using Antheraea mylitta sericin crosslinked with well known biocompatible polysaccharide chitosan by natural crosslinker (genipin) without using any harsh chemical. The fabricated matrices are characterized in terms of chemical modifications (Fourier transform infrared spectroscopy), crystallinity (X-ray diffraction), swelling, degradability and thermal stability...
July 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28433149/fabrication-and-evaluation-of-thermosensitive-chitosan-collagen-%C3%AE-%C3%AE-glycerophosphate-hydrogels-for-tissue-regeneration
#12
Qifeng Dang, Kai Liu, Zhenzhen Zhang, Chengsheng Liu, Xi Liu, Ying Xin, Xiaoyu Cheng, Tao Xu, Dongsu Cha, Bing Fan
Thermosensitive hydrogels whose physiological properties are similar to extracellular matrix have been extensively used for tissue regeneration. Polysaccharides and proteins, as biocompatible substrates similar to bio-macromolecules that could be recognized by human body, are two preferred polymers for fabrication of such hydrogels. A series of novel thermosensitive hydrogels (CS-ASC-HGs) containing chitosan (CS) and acid-soluble collagen (ASC) were thus prepared, in the presence of α, β-glycerophosphate, to mimic extracellular microenvironment for tissue regeneration...
July 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28433142/enhanced-degradation-of-chitosan-by-applying-plasma-treatment-in-combination-with-oxidizing-agents-for-potential-use-as-an-anticancer-agent
#13
Chayanaphat Chokradjaroen, Ratana Rujiravanit, Anyarat Watthanaphanit, Sewan Theeramunkong, Nagahiro Saito, Kazuko Yamashita, Ryuichi Arakawa
Solution plasma (SP) treatment in combination with oxidizing agents, i.e., hydrogen peroxide (H2O2), potassium persulfate (K2S2O8) and sodium nitrite (NaNO2) were adopted to chitosan degradation in order to achieve fast degradation rate, low chemicals used and high yield of low-molecular-weight chitosan and chitooligosaccharide (COS). Among the studied oxidizing agents, H2O2 was found to be the best choice in terms of appreciable molecular weight reduction without major change in chemical structure of the degraded products of chitosan...
July 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28432772/studies-on-the-chitin-chitosan-binding-properties-of-six-cuticular-proteins-analogous-to-peritrophin-3-from-bombyx-mori
#14
M Qu, Y Ren, Y Liu, Q Yang
Chitin deacetylation is required to make the cuticle rigid and compact through chitin chain crosslinking. Thus it is presumed that specialized proteins are required to bind deacetylated chitin chains together. However, deacetylated-chitin binding proteins have not ever been reported. In a previous work, six cuticular proteins analogous to peritrophin 3 (CPAP3s) were found to be abundant in the moulting fluid of Bombyx mori. In this study, these BmCPAP3s (BmCPAP3-A1, BmCPAP3-A2, BmCPAP3-B, BmCPAP3-C, BmCPAP3-D1 and BmCPAP3-D2) were cloned and expressed in Escherichia coli and purified using metal-chelating affinity chromatography...
April 22, 2017: Insect Molecular Biology
https://www.readbyqxmd.com/read/28432262/quantitative-imaging-of-cerebral-thromboemboli-in-vivo-the-effects-of-tissue-type-plasminogen-activator
#15
Dong-Eog Kim, Jeong-Yeon Kim, Dawid Schellingerhout, Ju Hee Ryu, Su-Kyoung Lee, Sangmin Jeon, Ji Sung Lee, Jiwon Kim, Hee Jeong Jang, Jung E Park, Eo Jin Kim, Ick Chan Kwon, Cheol-Hee Ahn, Matthias Nahrendorf, Kwangmeyung Kim
BACKGROUND AND PURPOSE: Quantitative imaging for the noninvasive assessment of thrombolysis is needed to advance basic and clinical thrombosis-related research and tailor tissue-type plasminogen activator (tPA) treatment for stroke patients. We quantified the evolution of cerebral thromboemboli using fibrin-targeted glycol chitosan-coated gold nanoparticles and microcomputed tomography, with/without tPA therapy. METHODS: We injected thrombi into the distal internal carotid artery in mice (n=50)...
April 21, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28431942/chitosan-based-nanocomplexes-for-simultaneous-loading-burst-reduction-and-controlled-release-of-doxorubicin-and-5-fluorouracil
#16
Antonio Di Martino, Pavel Kucharczyk, Zdenka Capakova, Petr Humpolicek, Vladimir Sedlarik
In this work, nanocomplexes based on chitosan grafted by carboxy-modified polylactic acid (SPLA) were prepared with the aim of loading simultaneously two anticancer drugs - doxorubicin and 5-fluorouracil, as well as to control their release, reduce the initial burst and boost cytotoxicity. The SPLA was prepared by a polycondensation reaction, using pentetic acid as the core molecule, and linked to the chitosan backbone through a coupling reaction. Nanocomplexes loaded with both drugs were formulated by the polyelectrolyte complexation method...
April 18, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28430676/a-biomimetic-alternative-to-synthetic-hydroxyapatite-boron-containing-bone-like-hydroxyapatite-precipitated-from-simulated-body-fluid
#17
Mert Calis, Tugrul Tolga Demirtas, Alper Vatansever, Gulseren Irmak, Ahmet Hamdi Sakarya, Pergin Atilla, Figen Ozgur, Menemse Gumusderelioglu
BACKGROUND: Biological hydroxyapatite (HA), has several mechanical and physical advantages over the commercially available synthetic apatite (CAP-HA). The aim of this in vivo study was to investigate the effect of osteoinductive "bone-like hydroxyapatite" obtained from simulated body fluid (SBF) combined with osteoinductive "boron" (B) on bone healing. MATERIALS: Bone like nanohydroxyapatite (SBF-HA) was precipitated from 10× simulated body fluid (10×SBF). Thirty Sprague-Dawley rats were randomly divided into 5 experimental groups (n = 6 each)...
April 20, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28429928/a-dual-enzyme-hydrogen-peroxide-generation-machinery-in-hydrogels-supports-antimicrobial-wound-treatment
#18
Daniela Huber, Gregor Tegl, Anna Mensah, Bianca Beer, Martina Baumann, Nicole Borth, Christoph Sygmund, Roland Ludwig, Georg M Guebitz
The aging population and accompanying diseases like diabetes resulted in an increased occurrence of chronic wounds. Topical wound treatment with antimicrobial agents to inhibit bacterial invasion and promote wound healing is often associated with difficulties. Here, we investigated the potential of succinyl chitosan (SC) - carboxymethyl cellulose (CMC) hydrogels which constantly release clinically relevant levels of hydrogen peroxide (H2O2). CMC hydrogel matrix was in-situ converted by limited hydrolysis by a cellulase into substrates accepted by cellobiose dehydrogenase (CDH) for continuous production of H2O2 (30 µM over 24 h)...
April 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28427172/the-amelioration-of-cartilage-degeneration-by-photo-crosslinked-gelha-hydrogel-and-crizotinib-encapsulated-chitosan-microspheres
#19
Pengfei Chen, Sheng Mei, Chen Xia, Ren Zhu, Yichuan Pang, Jiying Wang, Jianfeng Zhang, Fangchun Shao, Shunwu Fan
The present study aimed to investigate the synergistic therapeutic effect of decreaseing cartilage angiogenesis via exposure to crizotinib encapsulated by chitosan microspheres and photo-crosslinked hydrogel, with the goal of evaluating crizotinib as a treatment for osteoarthritis. First, we developed and evaluated the characteristics of hydrogels and chitosan microspheres. Next, we measured the effect of crizotinib on the cartilage degeneration induced by interleukin-1β in chondrocytes. Crizotinib ameliorated the pathological changes induced by interleukin-1β via its anti-angiogenesis function...
February 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28426772/correction-chitosan-propolis-nanoparticle-formulation-demonstrates-anti-bacterial-activity-against-enterococcus-faecalis-biofilms
#20
Teik Hwa Ong, Ebenezer Chitra, Srinivasan Ramamurthy, Rajinikanth Paruvathanahalli Siddalingam, Kah Hay Yuen, Stephen Periathamby Ambu, Fabian Davamani
[This corrects the article DOI: 10.1371/journal.pone.0174888.].
2017: PloS One
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