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https://www.readbyqxmd.com/read/28073593/integrative-cardiopulmonary-ultrasound-for-interstitial-lung-disease-assessment-correlation-between-lung-ultrasound-performance-and-cardiac-involvement
#1
Wei-Wei Zhu, Yi-Dan Li, Hong Li, Xiu-Zhang Lu, Ling-Yun Kong, Xiao-Guang Ye, Qi-Zhe Cai, Lan-Lan Sun, Wei Jiang, Li Wang
The aims of this study were to apply integrative cardiopulmonary ultrasound (thoracic ultrasound) to the evaluation of patients with interstitial lung disease (ILD) and to determine the relationship between lung ultrasound signs and echocardiographic parameters such as systolic pulmonary artery pressure (SPAP) and various right ventricular parameters. ILD patients and healthy controls underwent lung ultrasound (LUS) and echocardiographic tests. In addition to traditional echocardiographic parameters, right ventricular free wall longitudinal strain (RVLS_FW) was measured using 2-D speckle-tracking echocardiography...
January 7, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28070915/mitral-valve-resistance-determines-hemodynamic-consequences-of-severe-rheumatic-mitral-stenosis-and-immediate-outcomes-of-percutaneous-valvuloplasty
#2
Hamidreza Sanati, Reza Zolfaghari, Niloufar Samiei, Yousef Rezaei, Mitra Chitsazan, Ali Zahedmehr, Farshad Shakerian, Reza Kiani, Ata Firouzi, Reza Rezaei Tabrizi
INTRODUCTION: The mitral valve area (MVA) poorly reflects the hemodynamic status of (MS). In this study, we compared the MVA with mitral valve resistance (MVR) with regard to the determination of hemodynamic consequences of MS and the immediate outcomes of percutaneous balloon mitral valvuloplasty (PBMV). METHODS: In a prospective study, 36 patients with severe rheumatic MS with left ventricular ejection fraction (LVEF) >50% were evaluated. They underwent transthoracic echocardiography (TTE) and catheterization...
January 10, 2017: Echocardiography
https://www.readbyqxmd.com/read/28063199/diagnostic-accuracy-of-echocardiography-combined-with-chest-ct-in-pulmonary-hypertension
#3
Adil Shujaat, Abubakr A Bajwa, Farah Al-Saffar, Jason Bellardini, Lisa Jones, James D Cury
BACKGROUND: Transthoracic echocardiography (TTE) and computerized axial tomography (CT) are complementary imaging techniques. It is possible that a combination of the two may offer a better way of identifying pulmonary hypertension (PH) than either one alone. OBJECTIVES: To determine the diagnostic accuracy of TTE combined with chest CT in pulmonary hypertension. METHODS: We performed a retrospective review of consecutive patients who had undergone TTE, CT and right heart catheterization (RHC) between 7/1/2008 and 6/30/2012...
January 7, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28004166/anti-angiotensin-ii-type-1-receptor-autoantibodies-at1r-aas-in-patients-with-systemic-sclerosis-lack-of-association-with-disease-manifestations
#4
Ufuk İlgen, Müçteba Enes Yayla, Nurşen Düzgün
Angiotensin II type 1 receptor autoantibodies (AT1R-AAs) are known to be associated with malignant hypertension, preeclampsia, and vascular rejection in kidney transplantation. They were also suspected to have pathogenetic role in vasculopathic changes in systemic sclerosis (SSc). Clinical data regarding AT1R-AAs in SSc are scarce. In this work, we will examine the relationship between serum levels of AT1R-AAs and disease manifestations. Serum samples from SSc patients and healthy controls were analyzed for AT1R-AAs by using a commercial ELISA kit...
December 21, 2016: Rheumatology International
https://www.readbyqxmd.com/read/27992469/statins-have-no-additional-benefit-for-pulmonary-hypertension-a-meta-analysis-of-randomized-controlled-trials
#5
Lin Wang, Moying Qu, Yao Chen, Yaxiong Zhou, Zhi Wan
OBJECTIVES: We performed a meta-analysis to explore the effects of adding statins to standard treatment on adult patients of pulmonary hypertension (PH). METHODS: A systematic search up to December, 2015 of Medline, EMBASE, Cochrane Database of Systematic reviews and Cochrane Central Register of Controlled Trials was performed to identify randomized controlled trials with PH patients treated with statins. RESULTS: Five studies involving 425 patients were included into this meta-analysis...
2016: PloS One
https://www.readbyqxmd.com/read/27989082/impact-of-prosthesis-patient-mismatch-after-mitral-valve-replacement
#6
Calogera Pisano, Carmela Rita Balistreri, Oreste Fabio Triolo, Rosalba Franchino, Alberto Allegra, Veronica Capuccio, Vincenzo Argano, Giovanni Ruvolo
BACKGROUND: The study aim was to determine the impact of prosthesis-patient mismatch (PPM) on early and late clinical outcomes, left atrial and ventricular remodeling, late tricuspid valve regurgitation and pulmonary hypertension (PH) in patients after mitral valve replacement (MVR). METHODS: A total of 46 patients (mean age 66 ± 9.3 years) with mitral valve diseases and undergoing isolated MVR was enrolled in the study. The mitral valve effective orifice area (EOA) was determined using the continuity equation and indexed for the patient's body surface area (EOAi)...
January 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/27988518/conduction-abnormalities-after-transcatheter-aortic-valve-implantation-and-diastolic-dysfunction
#7
Ofir Priesler, Simon Biner, Ariel Finkelstein, Yoav Michowitz
OBJECTIVES: Transcatheter aortic valve implantation (TAVI) is frequently associated with the development of conduction abnormalities. We assessed the effect of conduction abnormalities on diastolic function following TAVI. METHODS: In total, 101 consecutive post-TAVI patients were included, each with echocardiographic follow-up at 1 and 6 months. Diastolic properties were correlated with the occurrence of a long PR interval and wide QRS, and their change from baseline...
December 17, 2016: Cardiology
https://www.readbyqxmd.com/read/27977800/structural-and-functional-characterization-of-the-bacterial-type-iii-secretion-export-apparatus
#8
Tobias Dietsche, Mehari Tesfazgi Mebrhatu, Matthias J Brunner, Patrizia Abrusci, Jun Yan, Mirita Franz-Wachtel, Charlotta Schärfe, Susann Zilkenat, Iwan Grin, Jorge E Galán, Oliver Kohlbacher, Susan Lea, Boris Macek, Thomas C Marlovits, Carol V Robinson, Samuel Wagner
Bacterial type III protein secretion systems inject effector proteins into eukaryotic host cells in order to promote survival and colonization of Gram-negative pathogens and symbionts. Secretion across the bacterial cell envelope and injection into host cells is facilitated by a so-called injectisome. Its small hydrophobic export apparatus components SpaP and SpaR were shown to nucleate assembly of the needle complex and to form the central "cup" substructure of a Salmonella Typhimurium secretion system. However, the in vivo placement of these components in the needle complex and their function during the secretion process remained poorly defined...
December 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27976528/streptococcus-mutans-spap-binds-to-radd-of-fusobacterium-nucleatum-ssp-polymorphum
#9
Lihong Guo, Bhumika Shokeen, Xuesong He, Wenyuan Shi, Renate Lux
Adhesin-mediated bacterial interspecies interactions are important elements in oral biofilm formation. They often occur on a species-specific level, which could determine health- or disease association of a biofilm community. Among the key players involved in these processes are the ubiquitous fusobacteria that have been recognized for their ability to interact with numerous different binding partners. Fusobacterial interactions with Streptococcus mutans, an important oral cariogenic pathogen, have previously been described but most studies focused on binding to non-mutans streptococci and specific cognate adhesin pairs remain to be identified...
December 15, 2016: Molecular Oral Microbiology
https://www.readbyqxmd.com/read/27940596/predicting-cardiopulmonary-involvement-in-patients-with-systemic-sclerosis-complementary-value-of-nailfold-videocapillaroscopy-patterns-and-disease-specific-autoantibodies
#10
Iris M Markusse, Jessica Meijs, Berber de Boer, Jaap A Bakker, H Pascal C Schippers, Anne A Schouffoer, Nina Ajmone Marsan, Lucia J M Kroft, Maarten K Ninaber, Tom W J Huizinga, Jeska K de Vries-Bouwstra
OBJECTIVE: To evaluate the prevalence of anti-extractable nuclear antigen (anti-ENA) antibodies in Dutch SSc patients and the predictive power of the combination of specific anti-ENA antibodies and nailfold videocapillaroscopy (NVC) patterns to improve identification of patients with high risk for cardiopulmonary involvement. METHODS: A total of 287 patients (79%) from the Leiden SSc-Cohort had data available on NVC-pattern (no SSc-specific, early, active, late) and anti-ENA antibodies...
December 10, 2016: Rheumatology
https://www.readbyqxmd.com/read/27925452/usefulness-of-admission-red-blood-cell-distribution-width-as-a-predictor-of-severity-of-acute-pulmonary-embolism
#11
Recep Akgedik, Harun Karamanli, Ali Bekir Kurt, Zeki Yüksel Günaydın
BACKGROUND: Previous researches have represented a considerable relation between acute pulmonary embolism (PE) and red blood cell distribution width (RDW). To the authors' knowledge no research has been informed in subjects with PE severity. Pulmonary arterial obstruction index (PAOI) is associated with the severity of acute PE. OBJECTIVES: In our investigation, we purposed to assess the relation between PAOI and RDW and the benefit of these factors in the detection of PE severity...
December 7, 2016: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/27919209/evaluation-of-echocardiographic-abnormalities-in-hiv-positive-patients-treated-with-antiretroviral-medications
#12
Sina Moradmand Badie, Mehrnaz Rasoulinejad, Mohammadreza Salehi, Hamid Emadi Kochak, SeyedAhmad SeyedAlinaghi, Seyed Ali Dehghan Manshadi, Fatemeh Jahanjo Amin Abad, Banafsheh Moradmand Badie
BACKGROUND: Echocardiography is a reliable means for the diagnosis of functional and valvular diseases of the heart in HIV positive and HIV negative patients. The current study was to evaluate echocardiographic abnormalities in HIV positive patients under an antiretroviral therapy (ART) program in Tehran, Imam Khomeini Hospital, Iran. METHODS: This is a descriptive cross-sectional study, conducted among 231 HIV positive patients under ART. All HIV positive patients including 150 men (65%) and 81 women (35%) (mean age of 41 years) were assessed by trans-thoracic echocardiography (TTE) in Imam Khomeini Hospital, over the period from 2013 to 2014...
December 5, 2016: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/27890771/echocardiographic-determinants-of-one-year-all-cause-mortality-in-patients-with-chronic-heart-failure-complicated-by-significant-functional-tricuspid-regurgitation
#13
Kai Hu, Dan Liu, Stefan Störk, Sebastian Herrmann, Daniel Oder, Georg Ertl, Wolfram Voelker, Frank Weidemann, Peter Nordbeck
BACKGROUND: Right ventricular (RV) dysfunction plays an important role in chronic heart failure (CHF). We evaluated the echocardiographic determinants of 1-year all-cause mortality in CHF patients with clinically relevant functional tricuspid regurgitation (TR). METHODS AND RESULTS: A total of 101 consecutive CHF patients (mean age 74 ± 10 years, 53% male) with moderate or severe functional TR were enrolled. Each patient underwent at least 2 echocardiography examinations in an interval of >6 months...
November 24, 2016: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/27796521/long-term-clinical-stabilization-of-scleroderma-patients-treated-with-a-chronic-and-intensive-iv-iloprost-regimen
#14
Rosario Foti, Elisa Visalli, Giorgio Amato, Alessia Benenati, Giovanni Converso, Alberto Farina, Salvatore Bellofiore, Massimiliano Mulè, Marcella Di Gangi
Intravenous iloprost is a first-line option for the treatment of scleroderma-related digital vasculopathy, and some studies have suggested its favourable role on disease progression. The aim of our study is to evaluate the disease progression, specifically in terms of cardiopulmonary function, in a group of consecutive patients chronically treated with intravenous iloprost. Our retrospective study enrolled 68 scleroderma patients (68 F, 54.4 ± 12.3 years) treated with iloprost for 7.1 ± 2.9 years, with a schedule of 5-6 consecutive daily infusions per month (6 h/day, 0...
October 28, 2016: Rheumatology International
https://www.readbyqxmd.com/read/27744392/effects-of-longterm-treatment-with-bosentan-and-iloprost-on-nailfold-absolute-capillary-number-fingertip-blood-perfusion-and-clinical-status-in-systemic-sclerosis
#15
Amelia Chiara Trombetta, Carmen Pizzorni, Barbara Ruaro, Sabrina Paolino, Alberto Sulli, Vanessa Smith, Maurizio Cutolo
OBJECTIVE: To quantify in patients with systemic sclerosis (SSc) the absolute nailfold capillary number/mm (the absolute number of capillaries, observable in the first row, in 1 mm per field) and fingertip blood perfusion (FBP) during longterm therapy with the endothelin receptor antagonist bosentan (BOSE) and the synthetic analog of prostacyclin PGI2 iloprost (ILO) by multiple diagnostic tools. Observed values were correlated with clinical outcomes. METHODS: Thirty patients with SSc already receiving intravenous ILO (80 μg/day) for 5 continuous days (every 3 mos) were recruited in the clinic...
October 1, 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27742061/detection-of-elevated-pulmonary-pressures-by-the-ecg-derived-ventricular-gradient-a-comparison-of-conversion-matrices-in-patients-with-suspected-pulmonary-hypertension
#16
Marlieke L A Haeck, Gijsbert F L Kapel, Roderick W C Scherptong, Cees A Swenne, Arie C Maan, Jeroen J Bax, Martin J Schalij, Hubert W Vliegen
BACKGROUND: The aim was to assess the diagnostic value of the Inverse Dower (INVD)-derived vectorcardiogram (VCG) and the Kors-derived VCG to detect elevated systolic pulmonary artery pressure (SPAP) in suspected pulmonary hypertension (PH). METHODS: In 132 patients, morphologic variables were evaluated by comparing the VCG parameters synthesized by INVD and Kors matrix. Comparison of the diagnostic accuracy of detecting SPAP ≥50mmHg between the matrices was performed by ROC curve analysis and logistic regression analysis...
January 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/27621775/noninvasive-model-including-right-ventricular-speckle-tracking-for-the-evaluation-of-pulmonary-hypertension
#17
Yossra Mahran, Robert Schueler, Marcel Weber, Carmen Pizarro, Georg Nickenig, Dirk Skowasch, Christoph Hammerstingl
AIM: To find parameters from transthorathic echocardiography (TTE) including speckle-tracking (ST) analysis of the right ventricle (RV) to identify precapillary pulmonary hypertension (PH). METHODS: Forty-four patients with suspected PH undergoing right heart catheterization (RHC) were consecutively included (mean age 63.1 ± 14 years, 61% male gender). All patients underwent standardized TTE including ST analysis of the RV. Based on the subsequent TTE-derived measurements, the presence of PH was assessed: Left ventricular ejection fraction (LVEF) was calculated by Simpsons rule from 4Ch...
August 26, 2016: World Journal of Cardiology
https://www.readbyqxmd.com/read/27617070/nt-probnp-in-children-with-left-to-right-shunt-and-dilated-cardiomyopathy
#18
Hala Mahmoud Koura, Neamat M Abdalla, Mona Hamed Ibrahim, Maha M A Abo Hashish, Sherif Mohamed Zaki
BACKGROUND: B-type natriuretic peptide (BNP) levels are elevated in children with congenital heart disease involving a left-to-right shunt (LRS) and are also raised in dilated cardiomyopathy (DCM). As far as we know, there are few reports in the literature comparing the change of the NT-proBNP in LRS and DCM especially in the pediatric age group. OBJECTIVES: The aim of the study was to compare the changes of the NT-proBNP in pediatric patients with LRS and DCM. Correlation between the levels of NT-proBNP and the echocardiographic parameters in both groups was determined...
June 2016: Iranian Journal of Pediatrics
https://www.readbyqxmd.com/read/27596111/echocardiographic-correlates-of-severe-pulmonary-hypertension-in-adult-patients-with-ostium-secundum-atrial-septal-defect
#19
Jorge Cossío-Aranda, Karina Del Valle Zamora, Navin C Nanda, Anezi Uzendu, Candace Keirns, Juan Verdejo-Paris, Marco Antonio Martínez-Ríos, Nilda Espinola-Zavaleta
OBJECTIVE: To identify echocardiographic factors that correlate with pulmonary hypertension (PH) in adults with ostium secundum atrial septal defect (ASD). METHODS: Between November 2009 and November 2013, 92 adults with ASD were studied. All had clinical history and transthoracic echocardiogram. RESULTS: Thirty-nine percent of patients had severe PH defined as systolic pulmonary artery pressure (sPAP) of 70 mm Hg or more. The size of ASD (31...
December 2016: Echocardiography
https://www.readbyqxmd.com/read/27587711/a-critical-appraisal-of-transpulmonary-and-diastolic-pressure-gradients
#20
M Louis Handoko, Frances S De Man, Frank P T Oosterveer, Harm-Jan Bogaard, Anton Vonk-Noordegraaf, Nico Westerhof
Pulmonary hypertension (PH) resulting from left heart failure is an increasingly recognized clinical entity. To distinguish isolated postcapillary PH from combined post- and precapillary PH, the use of a diastolic pressure gradient (DPG = diastolic Pulmonary Artery Pressure - Pulmonary Arterial Wedge Pressure, dPAP - PAWP) has been advocated over the transpulmonary pressure gradient (TPG = mean Pulmonary Artery Pressure - PAWP, mPAP - PAWP) since DPG was suggested to be independent of cardiac output (CO) and only slightly related to PAWP, while TPG depends on both...
September 2016: Physiological Reports
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