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https://www.readbyqxmd.com/read/28531295/right-ventricular-vascular-coupling-in-heart-failure-with-preserved-ejection-fraction-and-pre-vs-post-capillary-pulmonary-hypertension
#1
Thomas M Gorter, Dirk J van Veldhuisen, Adriaan A Voors, Yoran M Hummel, Carolyn S P Lam, Rolf M F Berger, Joost P van Melle, Elke S Hoendermis
Aims: Many patients with heart failure with preserved ejection fraction (HFpEF) develop post-capillary pulmonary hypertension (PH) due to increased left-sided filling pressures. However, a subset of patients develops combined post- and pre-capillary PH. We studied the value of echocardiographic right-sided characterization for the discrimination between pre- vs. post-capillary PH in HFpEF, using invasive haemodynamics as gold standard. Methods and results: 102 consecutive HFpEF patients with simultaneous right heart catheterization and echocardiography were identified...
May 22, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28530170/k-modulates-genetic-competence-and-the-stress-regulon-of-streptococcus-mutans
#2
Gursonika Binepal, Iwona B Wenderska, Paula Crowley, Richard N Besingi, Dilani B Senadheera, L Jeannine Brady, Dennis G Cvitkovitch
Potassium (K+) is the most abundant cation in dental plaque fluid. Previously, we reported the link between K+ transport via Trk2 in Streptococcus mutans and its two critical virulence attributes: acid tolerance and surface adhesion. Herein, we build further on the intimate link between K+ levels and S. mutans biology. High (>25 mM) versus low (≤5 mM) K+ concentrations in the growth medium affected conformational epitopes of cell surface-localized adhesin P1. At low K+, the expression of stress response elements gcrR and codY, cell-adhesion-associated genes such as spaP and metabolism-associated genes such as bglP was induced at stationary phase (P<0...
May 22, 2017: Microbiology
https://www.readbyqxmd.com/read/28526785/effects-of-arginine-on-growth-virulence-gene-expression-and-stress-tolerance-by-streptococcus-mutans
#3
Brinta Chakraborty, Robert A Burne
Streptococcus mutans is a common constituent of oral biofilms and a primary etiologic agent of human dental caries. The bacteria associated with dental caries have a potent ability to produce organic acids from dietary carbohydrates and to grow and metabolize in acidic conditions. In contrast, many commensal bacteria produce ammonia through the arginine deiminase system (ADS), which moderates the pH of oral biofilms. Arginine metabolism by the ADS is a significant deterrent to the initiation and progression of dental caries...
May 19, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28526545/obstructive-sleep-apnoea-and-right-ventricular-function-a-combined-assessment-by-speckle-tracking-and-three-dimensional-echocardiography
#4
Agostino Buonauro, Maurizio Galderisi, Ciro Santoro, Angelo Canora, Maria Luisa Bocchino, Francesco Lo Iudice, Maria Lembo, Roberta Esposito, Sabrina Castaldo, Bruno Trimarco, Alessandro Sanduzzi
BACKGROUND: Little is known on right ventricular (RV) involvement in obstructive sleep apnoea (OSA). This study aimed at evaluating early RV dysfunction by standard and advanced echocardiography in OSA. METHODS: Fifty-nine OSA patients without heart failure and 29 age-matched controls underwent standard, speckle tracking and real time 3D echocardiography of right ventricle. OSA patients performed lung function tests and overnight cardio-respiratory monitoring with evaluation of apnea-hypopnea index (AHI)...
May 4, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28524032/-preoperative-risk-factors-analysis-of-pulmonary-hypertension-crisis-during-perioperative-period-for-caesarean-section-of-woman-with-severe-pulmonary-hypertension
#5
Chunlei Zhang, Yaguang Liu, Enming Qing, Jun Ma
OBJECTIVE: To analyze preoperative risk factors of perioperative pulmonary hypertension crisis (PHC) for pregnant woman with severe pulmonary artery hypertension (PAH), and approach its clinical value. METHODS: A retrospective analysis was conducted. The clinical data from 152 pregnant women with severe PAH underwent cesarean delivery admitted to Beijing Anzhen Hospital from January 1st 2008 to December 31st 2016 was collected. The patients were divided into two groups according to with perioperative PHC or not...
May 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28517026/impact-of-severe-tricuspid-regurgitation-on-accuracy-of-systolic-pulmonary-arterial-pressure-measured-by-doppler-echocardiography-analysis-in-an-unselected-patient-population
#6
Beini Fei, Ting Fan, Ling Zhao, Xiaoli Pei, Xianhong Shu, Xiaoyan Fang, Leilei Cheng
Pulmonary arterial pressure is an important index in cardiovascular disorders, especially for pulmonary hypertension (PH). Doppler echocardiography (DE) is widely used as a noninvasive method to assess pulmonary arterial pressure. However, recent studies have found several hemodynamic factors that affect its accuracy in estimating systolic pulmonary arterial pressure (sPAP). But the effect of tricuspid regurgitation (TR) has not been investigated. Therefore, our study is aimed to determine whether the severity of TR will affect the accuracy of sPAP measured by DE in an unselected patient population...
May 18, 2017: Echocardiography
https://www.readbyqxmd.com/read/28507310/molecular-and-functional-characterization-of-the-bmpr2-gene-in-pulmonary-arterial-hypertension
#7
Guillermo Pousada, Vincenzo Lupo, Sheila Cástro-Sánchez, María Álvarez-Satta, Ana Sánchez-Monteagudo, Adolfo Baloira, Carmen Espinós, Diana Valverde
Pulmonary arterial hypertension is a progressive disease that causes the obstruction of precapillary pulmonary arteries and a sustained increase in pulmonary vascular resistance. The aim was to analyze functionally the variants found in the BMPR2 gene and to establish a genotype-phenotype correlation. mRNA expression studies were performed using pSPL3 vector, studies of subcellular localization were performed using pEGFP-N1 vector and luciferase assays were performed using pGL3-Basic vector. We have identified 30 variants in the BMPR2 gene in 27 of 55 patients...
May 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28458379/long-term-outcomes-of-suture-vs-ring-tricuspid-annuloplasty-for-functional-tricuspid-regurgitation
#8
Hiroki Hata, Tomoyuki Fujita, Sayaka Miura, Yusuke Shimahara, Yuta Kume, Yorihiko Matsumoto, Kizuku Yamashita, Junjiro Kobayashi
BACKGROUND: Whether there is a significant difference in the long-term surgical outcomes between suture annuloplasty and ring annuloplasty for the treatment of functional tricuspid regurgitation (TR) is still controversial. We compared the long-term outcomes of tricuspid annuloplasty (TAP) with and without an annuloplasty ring.Methods and Results:From January 1996 to December 2015, we consecutively enrolled 684 patients (mean age, 65.5 years; 60% women) undergoing TAP for functional TR: 312 underwent conventional suture annuloplasty (Group S) and 372 underwent ring annuloplasty (Group R)...
April 29, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28449486/the-prevalence-of-pulmonary-hypertension-in-patients-with-obesity-hypoventilation-syndrome-a-prospective-observational-study
#9
Aljohara S Almeneessier, Samar Z Nashwan, Mostafa Q Al-Shamiri, Seithikurippu R Pandi-Perumal, Ahmed S BaHammam
BACKGROUND: One important cardiovascular morbidity that is associated with obesity hypoventilation syndrome (OHS) is the development of pulmonary hypertension (PH). However, few studies have assessed PH in OHS patients. Therefore, we prospectively assessed the prevalence of PH in a large sample of OHS patients. METHODS: In this prospective observational study, all consecutive OHS patients referred to the sleep disorders clinic during the study period were included...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28380485/subclinical-atherosclerosis-in-patients-with-prior-pulmonary-thromboembolism
#10
Zafer Buyukterzi, Meral Buyukterzi, Ercan Kurtipek, Mehmet Sertac Alpaydin, Sukru Karaarslan
OBJECTIVE: Recent studies have indicated that endothelial dysfunction (ED) is common in patients with prior history of pulmonary thromboembolism (PTE). Based on the established relationship between ED and atherosclerosis, in this study, we aimed to investigate carotid intima- media thickness (cIMT) as a marker of subclinical atherosclerosis in patients who had prior history of PTE. SUBJECTS AND METHODS: Medical records of patients who had undergone transthoracic echocardiography in Konya Training and Research Hospital, included those that had a history of PTE, and age- and gender- matched patients without any history of PTE, were reviewed and echocardiographic findings and cIMT measurements were recorded...
April 4, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/28378162/coronary-flow-reserve-in-mitral-stenosis-before-and-after-percutaneous-balloon-mitral-valvuloplasty
#11
Ragab A Mahfouz, Mohammad Gouda, Waleed Elawdy, Ashraf Dewedar
We aimed to evaluate the coronary flow reserve (CFR) before and after percutaneous balloon mitral valvuloplasty (PBMV) in patients with mitral stenosis (MS) and its association to clinical events. A prospective study included 45 patients with mitral stenosis candidate for PBMV (age 38 ± 19 years, 27 were females) and 20 with matched age and sex, healthy controls were included in the study. Noninvasive CFR was measured using transthoracic echocardiography and utilizing adenosine stress echocardiography (0...
April 4, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28343949/lactate-and-echocardiography-before-veno-venous-extracorporeal-membrane-oxygenation-support
#12
Chiara Lazzeri, Manuela Bonizzoli, Giovanni Cianchi, Stefano Batacchi, Paolo Terenzi, Morena Cozzolino, Pasquale Bernardo, Adriano Peris
BACKGROUND: Lactate has been recognised as a prognostic factor in several critical conditions. Veno-Venous Extracorporeal Membrane Oxygenation (VV-ECMO) is a well-established therapy in patients with Acute Respiratory Disease Syndrome (ARDS) unresponsive to conventional therapy and echocardiography pre ECMO initiation has been recently reported to help in risk stratifying these patients. METHODS: We assessed whether the detection of hyperlactataemia could be associated with the presence of left ventricle (LV) or right ventricle (RV) dysfunction in 121 consecutive patients with refractory ARDS...
March 14, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28342708/hemodynamic-phenotyping-based-on-exercise-catheterization-predicts-outcome-in-patients-with-heart-failure-and-reduced-ejection-fraction
#13
Andreas Rieth, Manuel Jonas Richter, Henning Gall, Werner Seeger, Hossein A Ghofrani, Veselin Mitrovic, Christian W Hamm
BACKGROUND: Exercise right heart catheterization (RHC) unmasks different phenotypes based on hemodynamic response to exertion in patients with heart failure. The prognostic relevance of this approach in patients with heart failure and reduced ejection fraction (HFrEF) is uncertain. METHODS: We analyzed 167 patients with HFrEF from the Kerckhoff-Klinik Heart Failure Registry who underwent supine exercise RHC with constant external workload between September 2009 and August 2014...
February 28, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28294875/-efficiency-of-operation-trombendarterektomy-from-pulmonary-artery-branches-depending-on-the-degree-of-pulmonary-hypertension-and-duration-of-disease
#14
A M Chernyavskiy, A G Edemskiy, M A Chernyavskiy, V G Efimenko, A R Tarkova, S N Ivanov
AIM: to assess effect of thromboendarterectomy from pulmonary artery branches on clinical functional state of patients with chronic thromboembolic pulmonary hypertension (CTEPH) in dependence on degree of pulmonary hypertension and disease duration. MATERIAL: Patients (n=152) were divided into 3 groups: (1) with systolic pulmonary artery pressure (SPAP) less or equal 50 mm Hg (n=20), (2) with SPAP>50- less or equal 80mm Hg (n=46), (3) with SPAP >80mm Hg (n=86)...
May 2016: Kardiologiia
https://www.readbyqxmd.com/read/28283226/differential-impact-of-net-atrioventricular-compliance-on-clinical-outcomes-in-patients-with-mitral-stenosis-according-to-cardiac-rhythm
#15
In-Jeong Cho, Hyuk-Jae Chang, Soo Yeon Lee, Chi Young Shim, Geu-Ru Hong, Namsik Chung
BACKGROUND: Net atrioventricular compliance (Cn), a parameter for the net compliance of the left atrium and left ventricle, is known to be a useful predictor of outcomes in patients with mitral stenosis (MS). The present study aimed to evaluate whether the impact of Cn on symptom status and clinical outcomes, as well as its contribution toward systolic pulmonary artery pressure (SPAP), differed according to cardiac rhythm. METHODS: We retrospectively reviewed patients (N = 308) with rheumatic pure MS...
March 7, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28280732/paroxysmal-atrial-fibrillation-in-the-course-of-acute-pulmonary-embolism-clinical-significance-and-impact-on-prognosis
#16
Agnieszka Krajewska, Katarzyna Ptaszynska-Kopczynska, Izabela Kiluk, Urszula Kosacka, Robert Milewski, Jacek Krajewski, Wlodzimierz Jerzy Musial, Bozena Sobkowicz
The relationship and clinical implications of atrial fibrillation (AF) in acute pulmonary embolism (PE) are poorly investigated. We aimed to analyze clinical characteristics and prognosis in PE patients with paroxysmal AF episode. Methods. From the 391 patients with PE 31 subjects with paroxysmal AF were selected. This group was compared with patients with PE and sinus rhythm (SR) and 32 patients with PE and permanent AF. Results. Paroxysmal AF patients were the oldest. Concomitant DVT varies between groups: paroxysmal AF 32...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28248192/construction-of-crystal-structure-prototype-database-methods-and-applications
#17
Chuanxun Su, Jian Lv, Quan Li, Hui Wang, Lijun Zhang, Yanchao Wang, Yanming Ma
Crystal structure prototype data have become a useful source of information for materials discovery in the fields of crystallography, chemistry, physics, and materials science. This work reports the development of a robust and efficient method for assessing the similarity of structures on the basis of their interatomic distances. Using this method, we proposed a simple and unambiguous definition of crystal structure prototype based on hierarchical clustering theory, and constructed the crystal structure prototype database (CSPD) by filtering the known crystallographic structures in a database...
April 26, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28238241/mitral-patient-prosthesis-mismatch-predicts-suboptimal-hemodynamic-recovery-after-mitral-valve-replacement
#18
Sertan Ozyalcin, Kerem M Vural, Ayse Colak
BACKGROUND: A possible relationship between an obstructive prosthesis and suboptimal hemodynamic recovery, as reflected by unsatisfactory regression in systolic pulmonary artery pressure (sPAP) and functional tricuspid regurgitation (FTR) following mitral valve replacement (MVR), was investigated. A delineating effective orifice area index (EOAI) value was sought in order to define a patient-prosthesis mismatch. METHODS: A total of 128 patients undergoing isolated mechanical MVR were followed up for a mean of 46 ± 9 months...
September 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28223154/idiopathic-and-systemic-sclerosis-associated-pulmonary-arterial-hypertension-a-comparison-of-demographic-haemodynamic-and-magnetic-resonance-imaging-characteristics-and-outcomes
#19
Sheila Ramjug, Nehal Hussain, Judith Hurdman, Catherine Billings, Athanasios Charampopoulos, Charlie A Elliot, David G Kiely, Ian Sabroe, Smitha Rajaram, Andrew J Swift, Robin Condliffe
BACKGROUND: Previous studies have identified survival in systemic sclerosis (SSc)-associated pulmonary arterial hypertension (SSc-PAH) to be worse than in idiopathic pulmonary arterial hypertension (IPAH). We investigated differences between these conditions by comparing demographic, haemodynamic and radiological characteristics and outcomes in a large cohort of incident patients. METHODS: 651 patients diagnosed with IPAH or SSc-associated pre-capillary pulmonary hypertension were included...
February 18, 2017: Chest
https://www.readbyqxmd.com/read/28213866/5-aminosalicylic-acid-attenuates-monocrotaline-induced-pulmonary-arterial-hypertension-in-rats-by-increasing-the-expression-of-nur77
#20
Ling-Yue Sun, Zong-Ye Cai, Jun Pu, Jian Li, Jie-Yan Shen, Cheng-de Yang, Ben He
The aim of this study is to investigate the effect of 5-aminosalicylic acid (5-ASA) on monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH) in rats and its molecular mechanism. Sixty male Sprague-Dawley rats (250-300 g) were evenly randomized into six groups: control group; PAH group induced by MCT intraperitoneal injection (50 mg/kg) on day 1; and four PAH groups treated for 30 days from day 2 with 5-ASA at 50 (5-ASA-50 group), 100 (5-ASA-100 group), 150 (5-ASA-150 group), and 200 mg/kg/day (5-ASA-200 group), respectively...
February 17, 2017: Inflammation
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