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Amelia Chiara Trombetta, Carmen Pizzorni, Barbara Ruaro, Sabrina Paolino, Alberto Sulli, Vanessa Smith, Maurizio Cutolo
OBJECTIVE: To quantify in patients with systemic sclerosis (SSc) the absolute nailfold capillary number/mm (the absolute number of capillaries, observable in the first row, in 1 mm per field) and fingertip blood perfusion (FBP) during longterm therapy with the endothelin receptor antagonist bosentan (BOSE) and the synthetic analog of prostacyclin PGI2 iloprost (ILO) by multiple diagnostic tools. Observed values were correlated with clinical outcomes. METHODS: Thirty patients with SSc already receiving intravenous ILO (80 μg/day) for 5 continuous days (every 3 mos) were recruited in the clinic...
October 1, 2016: Journal of Rheumatology
Marlieke L A Haeck, Gijsbert F L Kapel, Roderick W C Scherptong, Cees A Swenne, Arie C Maan, Jeroen J Bax, Martin J Schalij, Hubert W Vliegen
BACKGROUND: The aim was to assess the diagnostic value of the Inverse Dower (INVD)-derived vectorcardiogram (VCG) and the Kors-derived VCG to detect elevated systolic pulmonary artery pressure (SPAP) in suspected pulmonary hypertension (PH). METHODS: In 132 patients, morphologic variables were evaluated by comparing the VCG parameters synthesized by INVD and Kors matrix. Comparison of the diagnostic accuracy of detecting SPAP ≥50mmHg between the matrices was performed by ROC curve analysis and logistic regression analysis...
September 8, 2016: Journal of Electrocardiology
Yossra Mahran, Robert Schueler, Marcel Weber, Carmen Pizarro, Georg Nickenig, Dirk Skowasch, Christoph Hammerstingl
AIM: To find parameters from transthorathic echocardiography (TTE) including speckle-tracking (ST) analysis of the right ventricle (RV) to identify precapillary pulmonary hypertension (PH). METHODS: Forty-four patients with suspected PH undergoing right heart catheterization (RHC) were consecutively included (mean age 63.1 ± 14 years, 61% male gender). All patients underwent standardized TTE including ST analysis of the RV. Based on the subsequent TTE-derived measurements, the presence of PH was assessed: Left ventricular ejection fraction (LVEF) was calculated by Simpsons rule from 4Ch...
August 26, 2016: World Journal of Cardiology
Hala Mahmoud Koura, Neamat M Abdalla, Mona Hamed Ibrahim, Maha M A Abo Hashish, Sherif Mohamed Zaki
BACKGROUND: B-type natriuretic peptide (BNP) levels are elevated in children with congenital heart disease involving a left-to-right shunt (LRS) and are also raised in dilated cardiomyopathy (DCM). As far as we know, there are few reports in the literature comparing the change of the NT-proBNP in LRS and DCM especially in the pediatric age group. OBJECTIVES: The aim of the study was to compare the changes of the NT-proBNP in pediatric patients with LRS and DCM. Correlation between the levels of NT-proBNP and the echocardiographic parameters in both groups was determined...
June 2016: Iranian Journal of Pediatrics
Jorge Cossío-Aranda, Karina Del Valle Zamora, Navin C Nanda, Anezi Uzendu, Candace Keirns, Juan Verdejo-Paris, Marco Antonio Martínez-Ríos, Nilda Espinola-Zavaleta
OBJECTIVE: To identify echocardiographic factors that correlate with pulmonary hypertension (PH) in adults with ostium secundum atrial septal defect (ASD). METHODS: Between November 2009 and November 2013, 92 adults with ASD were studied. All had clinical history and transthoracic echocardiogram. RESULTS: Thirty-nine percent of patients had severe PH defined as systolic pulmonary artery pressure (sPAP) of 70 mm Hg or more. The size of ASD (31...
September 5, 2016: Echocardiography
M Louis Handoko, Frances S De Man, Frank P T Oosterveer, Harm-Jan Bogaard, Anton Vonk-Noordegraaf, Nico Westerhof
Pulmonary hypertension (PH) resulting from left heart failure is an increasingly recognized clinical entity. To distinguish isolated postcapillary PH from combined post- and precapillary PH, the use of a diastolic pressure gradient (DPG = diastolic Pulmonary Artery Pressure - Pulmonary Arterial Wedge Pressure, dPAP - PAWP) has been advocated over the transpulmonary pressure gradient (TPG = mean Pulmonary Artery Pressure - PAWP, mPAP - PAWP) since DPG was suggested to be independent of cardiac output (CO) and only slightly related to PAWP, while TPG depends on both...
September 2016: Physiological Reports
Francesco Ferrara, Lawrence G Rudski, Olga Vriz, Luna Gargani, Jonathan Afilalo, Antonello D'Andrea, Michele D'Alto, Alberto M Marra, Edvige Acri, Anna Agnese Stanziola, Stefano Ghio, Antonio Cittadini, Robert Naeije, Eduardo Bossone
BACKGROUND: TAPSE provides a simple, reproducible estimate of the longitudinal function of the right ventricle (RV). However, the normal limits and physiologic correlates of tricuspid annular plane systolic excursion (TAPSE) are not exactly known. The aim of this study was to explore the full spectrum of TAPSE values and determine the physiologic correlates of TAPSE. METHODS AND RESULTS: From June 2007 to December 2013, 1168 healthy subjects [mean age 45.1±16years, range 16 to 92; 555 (47...
November 15, 2016: International Journal of Cardiology
Subeer Kanwar Wadia, Trushil G Shah, Grady Hedstrom, Julie A Kovach, Rajive Tandon
PURPOSE: Right ventricular (RV) dysfunction is an independent predictor of morbidity and mortality in acute respiratory distress syndrome (ARDS). Our goal was to describe morphologic changes in the RV using objective measures on transthoracic echocardiography (TTE) that occur following ARDS. METHODS: We retrospectively measured changes in the following RV parameters from a pre-ARDS TTE to an ARDS TTE: tricuspid annular plane systolic excursion (TAPSE), myocardial performance index (MPI), fractional area change (FAC), systolic pulmonary artery pressure (SPAP), peak tricuspid regurgitant (TR) velocity, and septal shift...
August 25, 2016: Echocardiography
Barış Akça, Köksal Dönmez, Olcay Murat Dişli, Feray Akgül Erdil, Mehmet Cengiz Çolak, İlhan Koray Aydemir, Bektaş Battaloğlu, Nevzat Erdil
BACKGROUND/AIM: To investigate the effects of pulmonary hypertension on early clinical variables in patients undergoing coronary artery bypass grafting surgery. MATERIALS AND METHODS: The preoperative echocardiographic data of patients who underwent isolated coronary artery bypass surgery were evaluated retrospectively. A total of 1244 patients were included in the study. The patients were divided into two groups: one group consisted of patients with systolic pulmonary artery pressure (SPAP) values equal to or greater than 30 mmHg (Group 1, n = 184), while the other group consisted of patients with SPAP values below 30 mmHg (Group 2, n = 1060)...
2016: Turkish Journal of Medical Sciences
André Y Denault, Jean S Bussières, Ramiro Arellano, Barry Finegan, Paul Gavra, François Haddad, Anne Q N Nguyen, France Varin, Annik Fortier, Sylvie Levesque, Yanfen Shi, Mahsa Elmi-Sarabi, Jean-Claude Tardif, Louis P Perrault, Jean Lambert
PURPOSE: Inhaled milrinone (iMil) has been used for the treatment of pulmonary hypertension (PH) but its efficacy, safety, and prophylactic effects in facilitating separation from cardiopulmonary bypass (CPB) and preventing right ventricular (RV) dysfunction have not yet been evaluated in a clinical trial. The purpose of this study was to investigate if iMil administered before CPB would be superior to placebo in facilitating separation from CPB. METHODS: High-risk cardiac surgical patients with PH were randomized to receive iMil or placebo after the induction of anesthesia and before CPB...
October 2016: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
Mollie Capone, John Matthew Bryant, Natalie Sutkowski, Azizul Haque
Members of the family of Fc receptor-like (FcRL) proteins, homologous to FcγRI, have been identified by multiple research groups. Consequently, they have been described using multiple nomenclatures including Fc receptor homologs (FcRH), immunoglobulin superfamily receptor translocation-associated genes (IRTA), immunoglobulin-Fc-gp42-related genes (IFGP), Src homology 2 domain-containing phosphatase anchor proteins (SPAP), and B cell cross-linked by anti-immunoglobulin M-activating sequences (BXMAS). They are now referred to under a unified nomenclature as FCRL...
June 2016: Journal of Clinical & Cellular Immunology
Erkan Gencer, Volkan Doğan, Müjgan Tek Öztürk, Aydın Nadir, Ahmet Musmul, Yüksel Cavuşoğlu
BACKGROUND: Cardiac troponins (cTn) are reliable and the most sensitive biomarker in the setting of acute decompensated heart failure (ADHF). Acute decompensated heart failure is usually associated with worsening chronic heart failure, and it may be caused by ongoing minor myocardial cell damage that may occur without any reported precipitating factors. METHODS: We compared the short-term effect of levosimendan (LEV), dobutamine (DOB), and vasodilator treatment (nitroglycerin [NTG]) on myocardial injury with hemodynamic, neurohumoral, and inflammatory indicators...
July 7, 2016: Journal of Cardiovascular Pharmacology and Therapeutics
Marcela Silva Lima, Carolina Maria Fontes Ferreira Nader, Letícia Paiva Franco, Zilda Maria Alves Meira, Flavio Diniz Capanema, Roberto Eustáquio Santos Guimarães, Helena Maria Gonçalves Becker
INTRODUCTION: Adenotonsillar hyperplasia (ATH) and allergic rhinitis (AR) are the most common causes of upper airway obstruction in children. Such diseases, by affecting the upper airways, can cause chronic alveolar hypoventilation, pulmonary vasoconstriction and pulmonary hypertension, which in some cases, are irreversible. OBJECTIVE: This cross-sectional study aimed to evaluate the prevalence of pulmonary hypertension in two groups of mouth-breathing (MB) 2-12 year old children with ATH and isolated allergic rhinitis, through Doppler echocardiography...
June 8, 2016: Brazilian Journal of Otorhinolaryngology
Rodolfo Citro, Eduardo Bossone, Guido Parodi, Scipione Carerj, Quirino Ciampi, Gennaro Provenza, Concetta Zito, Costantina Prota, Angelo Silverio, Olga Vriz, Antonello D'Andrea, Gennaro Galasso, Cesare Baldi, Fausto Rigo, Massimo Piepoli, Jorge Salerno-Uriarte, Federico Piscione
AIM: To determine the prevalence, clinical characteristics, in-hospital course and determinants of major adverse events in a cohort of Caucasian patients with Takotsubo syndrome (TTS) and right ventricular involvement (RVi), regardless of left ventricular variant forms. METHODS AND RESULTS: The study population consisted of 424 patients (mean age 69.1±11.5years; female 92.2%) with a diagnosis of TTS divided into two groups according to the presence or absence of RVi...
September 15, 2016: International Journal of Cardiology
Tarık Kıvrak, Erdal Durmuş, Murat Sünbül, Bedrettin Yıldızeli, Bülent Mutlu
OBJECTIVE: Pre- and postoperative changes in echocardiographic parameters and results of 6-minute walking test (6-MWT) were investigated in the present study. METHODS: Seventy-six patients (32 males, 44 females; mean age 45.9±15.1 years) were included. Before and after surgery, 6-MWT and echocardiography were performed. Changes in postoperative parameters were compared to basal walking test and other basal parameters. RESULTS: Distance covered in 6-MWT significantly increased after surgery (p<0...
June 2016: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
Rui Baptista, Sara Serra, Rui Martins, Rogério Teixeira, Graça Castro, Maria João Salvador, José António Pereira da Silva, Lèlita Santos, Pedro Monteiro, Mariano Pêgo
BACKGROUND: Pulmonary arterial hypertension (PAH) complicates the course of systemic sclerosis (SSc) and is associated with poor prognosis. The elevation of systolic pulmonary arterial pressure (sPAP) during exercise in patients with SSc with normal resting haemodynamics may anticipate the development of PAH. Exercise echocardiography (ExEcho) has been proposed as a useful technique to identify exercise-induced increases in sPAP, but it is unclear how to clinically interpret these findings...
2016: Arthritis Research & Therapy
Federico Perosa, Elvira Favoino, Isabella Eleonora Favia, Serena Vettori, Marcella Prete, Addolorata Corrado, Francesco Paolo Cantatore, Gabriele Valentini
Patients with systemic sclerosis (SSc) who express autoantibodies to centromeric proteins (CENPs) are at risk of developing pulmonary vascular disease and pulmonary arterial hypertension without fibrosis. Currently no biomarkers are available to predict these complications. We previously characterized the fine specificity of anti-CENP-A antibodies in SSc by screening a phage display library (expressing random 12-mer peptides), and identified phage clones whose peptides were differentially recognized by patients' autoantibodies...
June 2016: Medicine (Baltimore)
Luca Testa, Azeem Latib, Federico De Marco, Marco De Carlo, Claudia Fiorina, Rocco Montone, Mauro Agnifili, Marco Barbanti, Anna Sonia Petronio, Giuseppe Biondi Zoccai, Federica Ettori, Silvio Klugmann, Corrado Tamburino, Nedy Brambilla, Antonio Colombo, Francesco Bedogni
BACKGROUND: Severe pulmonary hypertension (PH) is considered to negatively affect the outcome after transcatheter aortic valve replacement. However, a clear understanding of the pattern, evolution, and clinical impact of different grades of PH in this setting is lacking. METHODS AND RESULTS: A total of 990 consecutive patients were enrolled in 6 high-volume centers and analyzed as follows: group 1, systolic pulmonary artery pressure (sPAP) <40 mm Hg (346 patients; 35%); group 2, sPAP 40 to 60 mm Hg (426 patients; 43%); and group 3, sPAP >60 mm Hg (218 patients; 22%)...
June 2016: Circulation. Cardiovascular Interventions
Marlieke L A Haeck, Georgette E Hoogslag, Helèn Boden, Matthijs A Velders, Spyridon Katsanos, Ibtihal Al Amri, Philippe Debonnaire, Martin J Schalij, Hubert W Vliegen, Jeroen J Bax, Nina Ajmone Marsan, Victoria Delgado
Elevated systolic pulmonary artery pressure (SPAP) after ST-segment elevation myocardial infarction (STEMI) has been associated with adverse outcome. However, little is known about the development of increased SPAP after STEMI treated with primary percutaneous coronary intervention. The aims of this study were to investigate the incidence and determinants of elevated SPAP (SPAP ≥36 mm Hg at 12 months) after first STEMI and to analyze its prognostic implications. A total of 705 patients (60 ± 12 years; 75% men; left ventricular ejection fraction [LVEF] 47 ± 9%) with first STEMI treated with primary percutaneous coronary intervention were evaluated...
August 1, 2016: American Journal of Cardiology
Takumi Yamamoto, Hidehiko Yoshimatsu, Kazuki Kikuchi
Dorsal skin defect of the hand/digit requires thin and pliable skin for coverage. The prepuce skin, the second thinnest skin, can be a reconstructive option, but there is no previous report of a free prepuce flap for the reconstruction of the hand/digit. We report the first successful case of a free prepuce flap based on the superficial penile artery perforator (SPAP) for the treatment of dorsal soft tissue defect of the hand/digit. A 68-year-old male presented with a 5 x 3 cm dorsal soft tissue defect of the left index finger with the extensor tendon exposure...
May 21, 2016: Microsurgery
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