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Vitamin B12 heart failure

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https://www.readbyqxmd.com/read/27597529/potential-health-hazards-of-eating-red-meat
#1
A Wolk
Red meat (beef, veal, pork, lamb and mutton) consumption contributes several important nutrients to the diet, for example essential amino acids, vitamins (including B12) and minerals (including iron and zinc). Processed red meat (ham, sausages, bacon, frankfurters, salami, etc.) undergoes treatment (curing, smoking, salting or the use of chemical preservatives and additives) to improve its shelf life and/or taste. During recent decades, consumption of red meat has been increasing globally, especially in developing countries...
September 6, 2016: Journal of Internal Medicine
https://www.readbyqxmd.com/read/27462097/homocysteine-lowering-for-stroke-prevention-unravelling-the-complexity-of-the-evidence
#2
J David Spence
Elevated levels of total homocysteine impair endothelial dysfunction and increase thrombosis. Homocysteine is causal in animal models, and in human studies, elevated total homocysteine is significantly associated with carotid atherosclerosis, lacunar infarction, and markedly increased risk of stroke in atrial fibrillation. Because two of the early large trials of B vitamin therapy (Vitamin Intervention for Stroke Prevention and the Norwegian Vitamin Study) did not show any reduction of stroke, and the Heart Outcomes Prevention Evaluation 2 trial was mistakenly interpreted as not showing a reduction of stroke (because the authors could not think of a biological difference between stroke and myocardial infarction), there has been widespread pessimism regarding treatment to lower total homocysteine for stroke prevention...
October 2016: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/27391912/relation-between-vitamin-b12-and-syntax-score
#3
Levent Cerit, Hamza Duygu, Kamil Gulsen, Hatice Kemal, Ozgur Tosun, Barcin Ozcem, Zeynep Cerit, Aziz Gunsel
BACKGROUND: Vitamin B12 is required in the metabolism of homocysteine. Vitamin B 12 deficiency has been implicated in endothelial dysfunction and cardiovascular disease via hyperhomocysteinemia. However, the association of vitamin B12, and severity of coronary artery disease has not been studied up to date. This study was conducted with the aim to evaluate the relationship between vitamin B12 and SYNTAX score. METHODS: Medical records of consecutive patients, who underwent CABG surgery, were retrospectively reviewed...
July 8, 2016: Kardiologia Polska
https://www.readbyqxmd.com/read/26209968/cardiogenic-differentiation-of-mesenchymal-stem-cells-with-gold-nanoparticle-loaded-functionalized-nanofibers
#4
Sreepathy Sridhar, Jayarama Reddy Venugopal, Radhakrishnan Sridhar, Seeram Ramakrishna
Cardiac tissue engineering promises to revolutionize the treatment of patients with end-stage heart failure and provide new solutions to the serious problems of shortage of heart donors. The influence of extracellular matrix (ECM) plays an influential role along with nanostructured components for guided stem cell differentiation. Hence, nanoparticle embedded Nanofibrous scaffolds of FDA approved polycaprolactone (PCL), Vitamin B12 (Vit B12), Aloe Vera(AV) and Silk fibroin(SF) was constructed to differentiate mesenchymal stem cells into cardiac lineage...
October 1, 2015: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/26043666/research-gaps-in-evaluating-the-relationship-of-meat-and-health
#5
REVIEW
David M Klurfeld
Humans evolved as omnivores and it has been proposed that cooking meat allowed for evolution of larger brains that has led to our success as a species. Meat is one of the most nutrient dense foods, providing high-quality protein, heme iron, zinc, and vitamins B6 and B12. Despite these advantages, epidemiologic studies have linked consumption of red or processed meat with obesity, type 2 diabetes, cardiovascular diseases, and cancers of multiple organs. Most observational studies report small, increased relative risks...
November 2015: Meat Science
https://www.readbyqxmd.com/read/25746727/effects-of-nutritional-supplementation-on-fatigue-and-autonomic-and-immune-dysfunction-in-patients-with-end-stage-renal-disease-a-randomized-double-blind-placebo-controlled-multicenter-trial
#6
RANDOMIZED CONTROLLED TRIAL
Sanae Fukuda, Hidenori Koyama, Kazuhiro Kondo, Hisako Fujii, Yoshinobu Hirayama, Tsutomu Tabata, Mikio Okamura, Tomoyuki Yamakawa, Shigeki Okada, Sumio Hirata, Hiroshi Kiyama, Osami Kajimoto, Yasuyoshi Watanabe, Masaaki Inaba, Yoshiki Nishizawa
BACKGROUND: Fatigue is a predictor of cardiovascular events in patients with end-stage renal disease (ESRD) undergoing hemodialysis treatment. We hypothesized that multinutritional support would improve quality of life, fatigue symptoms, and potential quantitative measures including endocrine, immune and autonomic functions in patients with ESRD undergoing hemodialysis. METHODS: Two hundred and two hemodialysis patients were randomly assigned to receive active treatment (containing vitamin B1, vitamin B2, niacin, vitamin B6, vitamin B12, folic acid, vitamin C, carnitine, coenzyme Q10, naïve galacto-oligosaccharide, and zinc) or placebo after each dialysis session for 12 weeks...
2015: PloS One
https://www.readbyqxmd.com/read/25592005/nutritional-factors-in-the-prevention-and-management-of-coronary-artery-disease-and-heart-failure
#7
REVIEW
Undurti N Das
Nutritional factors such as magnesium, folic acid, vitamins B12 and B6, L-arginine, and polyunsaturated fatty acids (PUFAs) appear to be significantly beneficial for patients with coronary artery disease (CAD), and in the prevention and arresting the progression of HF and cardiac arrhythmias. Additionally, ingestion of adequate amounts of protein and maintaining normal concentrations of plasma albumin seem to be essential for these patients. These nutrients closely interact with the metabolism of L-arginine-nitric oxide (NO) system, essential fatty acids, and eicosanoids such that beneficial products such as NO, prostaglandin E1, prostacyclin, prostaglandin I3, lipoxins, resolvins, and protectins are generated and synthesis of proinflammatory cytokines is suppressed that results in platelet anti-aggregation, vasodilation, angiogenesis, and prevention of CAD, cardiac arrhythmias, and stabilization of HF...
February 2015: Nutrition
https://www.readbyqxmd.com/read/25590290/homocysteine-lowering-interventions-for-preventing-cardiovascular-events
#8
REVIEW
Arturo J Martí-Carvajal, Ivan Solà, Dimitrios Lathyris
BACKGROUND: Cardiovascular disease, which includes coronary artery disease, stroke and congestive heart failure, is a leading cause of death worldwide. Homocysteine is an amino acid with biological functions in methionine metabolism. A postulated risk factor is an elevated circulating total homocysteine level, which is associated with cardiovascular events. The impact of homocysteine-lowering interventions, given to patients in the form of vitamins B6, B9 or B12 supplements, on cardiovascular events...
January 15, 2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/25324534/vitamin-b12-and-folate-deficiency-in-chronic-heart-failure
#9
MULTICENTER STUDY
Haye H van der Wal, Josep Comin-Colet, Ijsbrand T Klip, Cristina Enjuanes, Niels Grote Beverborg, Adriaan A Voors, Waldemar Banasiak, Dirk J van Veldhuisen, Jordi Bruguera, Piotr Ponikowski, Ewa A Jankowska, Peter van der Meer
OBJECTIVE: To determine the prevalence, clinical correlates and the effects on outcome of vitamin B12 and folic acid levels in patients with chronic heart failure (HF). METHODS: We studied an international pooled cohort comprising 610 patients with chronic HF. The main outcome measure was all-cause mortality. RESULTS: Mean age of the patients was 68±12 years and median serum N-terminal prohormone brain natriuretic peptide level was 1801 pg/mL (IQR 705-4335)...
February 2015: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/24662257/diamond-blackfan-anemia-and-nutritional-deficiency-induced-anemia-in-children
#10
REVIEW
David Gelbart
Diamond-Blackfan anemia is a rare, inherited disease that characteristically presents as a chronic, normochromic macrocytosis due to red cell lineage bone marrow failure. Although studies are elaborating on the genetic basis for its associated comorbidities, little has been published comparing this anemia to other chronic anemias that have similar laboratory results in children. This article offers a global perspective of the disease and compares it with anemia due to vitamin B12 and folate deficiency in children...
April 2014: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/24533076/a-genetic-variant-in-vitamin-b12-metabolic-genes-that-reduces-the-risk-of-congenital-heart-disease-in-han-chinese-populations
#11
Jue Wang, Jian-Yuan Zhao, Feng Wang, Qian-Qian Peng, Jia Hou, Shu-Na Sun, Yong-Hao Gui, Wen-Yuan Duan, Bin Qiao, Hong-Yan Wang
BACKGROUND: Genome-wide association studies on components of the one-carbon metabolic pathway revealed that human vitamin B12 levels could be significantly influenced by variations in the fucosyltransferase 2 (FUT2), cubilin (CUBN), and transcobalamin-I (TCN1) genes. An altered vitamin B12 level is an important factor that disturbs the homeostasis of the folate metabolism pathway, which in turn can potentially lead to the development of congenital heart disease (CHD). Therefore, we investigated the association between the variants of vitamin B12-related genes and CHD in Han Chinese populations...
2014: PloS One
https://www.readbyqxmd.com/read/24248213/cobalamin-deficiency-clinical-picture-and-radiological-findings
#12
REVIEW
Chiara Briani, Chiara Dalla Torre, Valentina Citton, Renzo Manara, Sara Pompanin, Gianni Binotto, Fausto Adami
Vitamin B12 deficiency causes a wide range of hematological, gastrointestinal, psychiatric and neurological disorders. Hematological presentation of cobalamin deficiency ranges from the incidental increase of mean corpuscular volume and neutrophil hypersegmentation to symptoms due to severe anemia, such as angor, dyspnea on exertion, fatigue or symptoms related to congestive heart failure, such as ankle edema, orthopnea and nocturia. Neuropsychiatric symptoms may precede hematologic signs and are represented by myelopathy, neuropathy, dementia and, less often, optic nerve atrophy...
November 2013: Nutrients
https://www.readbyqxmd.com/read/24112470/red-blood-cell-distribution-width-is-associated-with-incidence-of-atrial-fibrillation
#13
S Adamsson Eryd, Y Borné, O Melander, M Persson, J G Smith, B Hedblad, G Engström
OBJECTIVES: Red blood cell distribution width (RDW), a measure of variation in erythrocyte volume, has been associated with several cardiovascular disorders, but the relationship with atrial fibrillation (AF) remains unclear. We investigated the association between RDW and incidence of first hospitalization due to AF in a population-based cohort. DESIGN: Red blood cell distribution width was measured in 27,124 subjects from the general population (age 45-73 years, 62% women) with no history of AF, heart failure, myocardial infarction or stroke...
January 2014: Journal of Internal Medicine
https://www.readbyqxmd.com/read/23692411/anaemia-in-chronic-heart-failure-more-awareness-is-required
#14
A D Pisaniello, D T L Wong, I Kajani, K Robinson, S Shakib
AIMS: To determine the characteristics of anaemic patients, how well anaemia is investigated and its contributing factors in patients with chronic heart failure (CHF). METHODS: Retrospective analysis of longitudinal data collected during routine management of patients admitted with CHF at an Australian tertiary hospital. One thousand and twenty-one patients admitted with CHF between 1997 and 2005 were included. Anaemia was defined as a haemoglobin concentration <110 g/L...
September 2013: Internal Medicine Journal
https://www.readbyqxmd.com/read/23440809/homocysteine-lowering-interventions-for-preventing-cardiovascular-events
#15
REVIEW
Arturo J Martí-Carvajal, Ivan Solà, Dimitrios Lathyris, Despoina-Elvira Karakitsiou, Daniel Simancas-Racines
BACKGROUND: Cardiovascular disease (including coronary artery disease, stroke and congestive heart failure), is a leading cause of death worldwide. Homocysteine is an amino acid with biological functions in methionine metabolism. A postulated risk factor is elevated circulating total homocysteine levels, which are associated with cardiovascular events. This is an update of a review previously published in 2009. OBJECTIVES: To assess the clinical effectiveness of homocysteine-lowering interventions in people with or without pre-existing cardiovascular disease...
2013: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/23031430/oxygen-deficit-and-h2s-in-hemorrhagic-shock-in-rats
#16
Andry Van de Louw, Philippe Haouzi
INTRODUCTION: Hemorrhagic shock induced O2 deficit triggers inflammation and multiple organ failure (MOF). Endogenous H2S has been proposed to be involved in MOF since plasma H2S concentration appears to increase in various types of shocks and to predict mortality. We tested the hypothesis that H2S increases during hemorrhagic shock associated with O2 deficit, and that enhancing H2S oxidation by hydroxocobalamin could reduce inflammation, O2 deficit or mortality. METHODS: We used a urethane anesthetized rat model, where 25 ml/kg of blood was withdrawn over 30 minutes...
October 2, 2012: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/22605831/autoimmune-pernicious-anaemia-as-a-cause-of-collapse-heart-failure-and-marked-panyctopaenia-in-a-young-patient
#17
Justin Carey, Ebru Hack
A 35-year-old woman with a history of vitiligo, hypothyroidism and amenorrhoea presented with collapse and clinical features of cardiac failure. Laboratory investigations revealed pancytopaenia, the cause of which was found to be vitamin B12 deficiency due to pernicious anaemia. Treatment with intramuscular hydroxycobalamin was commenced and the patient improved steadily with concomitant improvement in her haematological indices. Clinical features of pernicious anaemia which can include marked pancytopaenia, diagnostic approach, associated conditions and approach to treatment are discussed...
2012: BMJ Case Reports
https://www.readbyqxmd.com/read/22528588/the-influence-of-vitamin-e-supplementation-on-erythropoietin-responsiveness-in-chronic-hemodialysis-patients-with-low-levels-of-erythrocyte-superoxide-dismutase
#18
Anca Rusu, Flaviu Rusu, Delia Zalutchi, Adina Muresan, Mirela Gherman Caprioara, Ina Kacso
About 12-15 % of hemodialysis patients have a poor response to recombinant human erythropoietin (rHuEPO). The aim of this prospective study was to examine the influence of oxidative stress and vitamin E supplementation on rHuEPO responsiveness in chronic hemodialysis patients. Sixty-five hemodialysis patients treated with rHuEPO were studied. Those with iron deficiency, blood loss, malignancy, vitamin B12 and folate deficiency, severe hyperparathyroidism, liver cirrhosis, and congestive heart failure were excluded...
April 2013: International Urology and Nephrology
https://www.readbyqxmd.com/read/21649592/-analysis-of-causes-of-development-of-anemia-in-patients-with-chronic-heart-failure
#19
S N Tereshchenko, T M Uskach, A G Kochetov
High prevalence of anemia and its direct relation with morbidity and mortality in congestive heart failure (CHF) has been shown in numerous studies. Among etiology factors of anemia are hemodilution, chronic kidney insufficiency, deficiency of iron, folate, and vitamin 12, high level of inflammatory cytokines. Aims of this study were elucidation of causes of anemia in patients with CHF and assessment of dependence of prognosis of these patients on etiology of anemia. We examined 317 patients hospitalized with diagnosis of NYHA class II-IVCHF and anemia (129, [40...
2011: Kardiologiia
https://www.readbyqxmd.com/read/21063931/management-of-anemia-and-iron-deficiency-in-heart-failure
#20
Eileen O'Meara, Simon de Denus
Anemia is independently associated with an increased risk of mortality and morbidity in patients with heart failure (HF). The diagnosis of anemia should prompt assessment of the underlying cause(s), first by using routine laboratory measurements (i.e., serum creatinine and estimated glomerular filtration rate [eGFR], serum iron, transferrin saturation, ferritin, vitamin B12, folic acid, and thyroid stimulating hormone). In clinical practice, it remains unclear whether using levels of the soluble transferrin receptor in HF patients to assess iron deficiency is warranted...
December 2010: Current Treatment Options in Cardiovascular Medicine
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