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https://www.readbyqxmd.com/read/28446149/effect-of-genetic-variants-and-traits-related-to-glucose-metabolism-and-their-interaction-with-obesity-on-breast-and-colorectal-cancer-risk-among-postmenopausal-women
#1
Su Yon Jung, Eric M Sobel, Jeanette C Papp, Zuo-Feng Zhang
BACKGROUND: Impaired glucose metabolism-related genetic variants and traits likely interact with obesity and related lifestyle factors, influencing postmenopausal breast and colorectal cancer (CRC), but their interconnected pathways are not fully understood. By stratifying via obesity and lifestyles, we partitioned the total effect of glucose metabolism genetic variants on cancer risk into two putative mechanisms: 1) indirect (risk-associated glucose metabolism genetic variants mediated by glucose metabolism traits) and 2) direct (risk-associated glucose metabolism genetic variants through pathways other than glucose metabolism traits) effects...
April 26, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28445130/single-nucleotide-polymorphisms-in-mlh1-predict-poor-prognosis-of-hepatocellular-carcinoma-in-a-chinese-population
#2
Xiaonian Zhu, Wei Liu, Xiaoqiang Qiu, Zhigang Wang, Chao Tan, Chunhua Bei, Linyuan Qin, Yuan Ren, Shengkui Tan
Hepatocellular carcinoma (HCC) is a malignant cancer causing deleterious health effect worldwide, especially in China. So far clinical cure rate and long-term survival rate of HCC remains low. Most HCC patients after cancer resection have recurrence or metastasis within 5 years. This study aims to explore the genetic association of mutL homolog 1 (MLH1) polymorphisms with HCC risk and prognosis. Four candidate MLH1 polymorphisms, rs1800734, rs10849, rs3774343 and rs1540354 were studied from a hospital-based case-control study including 1,036 cases (HCC patients) and 1,036 controls (non-HCC patients) in Guangxi, China...
April 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28443596/lack-of-association-between-toll-like-receptor-2-polymorphisms-r753q-and-a-16934t-and-atopic-dermatitis-in-children-from-thrace-region-of-turkey
#3
Can Ceren, Mehtap Yazıcıoğlu, Hakan Gürkan, Adnan Görgülü, Necdet Süt
BACKGROUND: Atopic dermatitis (AD) is the most common chronic inflammatory skin disease. A complex interaction of both genetic and environmental factors is thought to contribute to the disease. Recently relations between single nucleotide polymorphisms (SNPs) of toll-like receptors (TLRs) and AD have been reported. AIMS: The aim of the study was to evaluate whether SNPs in the TLR2 gene c.2258C>T (R753Q) (rs5743708) and TLR2 c.-148+1614T>A (A-16934T) (rs4696480) (NM_0032643) are associated with AD in Turkish children...
April 6, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28430929/promoter-polymorphism-rs886205-genotype-interacts-with-dna-methylation-of-the-aldh2-regulatory-region-in-alcohol-dependence
#4
Hansi Pathak, Helge Frieling, Stefan Bleich, Alexander Glahn, Annemarie Heberlein, Mani Haschemi Nassab, Thomas Hillemacher, Alexandra Burkert, Mathias Rhein
Aims: Aldehyde dehydrogenase 2 (ALDH2) protects cells from ethanol toxicity by metabolizing acetaldehyde. We studied the single nucleotide polymorphism (SNP) rs886205s located between a negative and a positive regulating promoter element in the ALDH2 gene. The negative regulatory region was already associated with differential DNA methylation in the two allele variations of rs886205 SNP. Another CpG island, in the positive regulatory region of the ALDH2 promoter, extends through the SNP rs886205 and a nuclear receptor response element...
May 1, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/28430897/genetic-variants-associated-with-the-root-system-architecture-of-oilseed-rape-brassica-napus-l-under-contrasting-phosphate-supply
#5
Xiaohua Wang, Yanling Chen, Catherine L Thomas, Guangda Ding, Ping Xu, Dexu Shi, Fabian Grandke, Kemo Jin, Hongmei Cai, Fangsen Xu, Bin Yi, Martin R Broadley, Lei Shi
Breeding crops with ideal root system architecture for efficient absorption of phosphorus is an important strategy to reduce the use of phosphate fertilizers. To investigate genetic variants leading to changes in root system architecture, 405 oilseed rape cultivars were genotyped with a 60K Brassica Infinium SNP array in low and high P environments. A total of 285 single-nucleotide polymorphisms were associated with root system architecture traits at varying phosphorus levels. Nine single-nucleotide polymorphisms corroborate a previous linkage analysis of root system architecture quantitative trait loci in the BnaTNDH population...
April 19, 2017: DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes
https://www.readbyqxmd.com/read/28429184/interactive-effects-of-salicylic-acid-and-nitric-oxide-in-alleviating-zinc-toxicity-of-safflower-carthamus-tinctorius-l
#6
Shahram Namdjoyan, Hossein Kermanian, Ali Abolhasani Soorki, Sedigheh Modarres Tabatabaei, Nazli Elyasi
The purpose of this study was to assess the possible protective role of exogenous salicylic acid (SA), sodium nitroprusside (SNP), a donor of nitric oxide, and their combination on 21-day-old safflower (Carthamus tinctorius L.) seedlings grown under zinc (Zn) stress. The results revealed that exposure to 500 µM ZnSO4.7H2O for 10 days markedly reduced the root and shoot dry weights in Zn-treated plants, while the application of SA, SNP and specially SA + SNP significantly increased the root and shoot dry weights in seedlings subjected to Zn stress...
April 20, 2017: Ecotoxicology
https://www.readbyqxmd.com/read/28424560/an-exploratory-study-of-host-polymorphisms-in-genes-that-clinically-characterize-breast-cancer-tumors-and-pretreatment-cognitive-performance-in-breast-cancer-survivors
#7
Theresa A Koleck, Catherine M Bender, Beth Z Clark, Christopher M Ryan, Puja Ghotkar, Adam Brufsky, Priscilla F McAuliffe, Priya Rastogi, Susan M Sereika, Yvette P Conley
PURPOSE: Inspired by the hypothesis that heterogeneity in the biology of breast cancers at the cellular level may account for cognitive dysfunction symptom variability in survivors, the current study explored relationships between host single-nucleotide polymorphisms (SNPs) in 25 breast cancer-related candidate genes (AURKA, BAG1, BCL2, BIRC5, CCNB1, CD68, CENPA, CMC2, CTSL2, DIAPH3, ERBB2, ESR1, GRB7, GSTM1, MELK, MKI67, MMP11, MYBL2, NDC80, ORC6, PGR, RACGAP1, RFC4, RRM2, and SCUBE2), identified from clinically relevant prognostic multigene-expression profiles for breast cancer, and pretreatment cognitive performance...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28422721/functional-analysis-implicating-the-snp-rs61552325-in-erbb2-as-an-effector-for-androgen-insensitive-prostate-cancer-cell-invasion
#8
Xianxiang Xin, Yinmin Gu, Yang Chen, Yuanjie Huang, Zengnan Mo, Yanling Hu
BACKGROUND: As one of the most common cancers in men, the pathogenesis of prostate cancer has been widely researched. Aberrant activation of the erb-b2 receptor tyrosine kinase 2 (ERBB2) has been found to play a critical role in metastatic prostate cancer. In our previous study, we demonstrated that rs61552325 (Pro1140Ala) located in ERBB2 is strongly correlated to prostate cancer. Therefore, we initially studied the effect of rs61552325 on androgen-independent prostate cancer cell metastasis...
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28418069/genetic-control-of-plasticity-of-oil-yield-for-combined-abiotic-stresses-using-a-joint-approach-of-crop-modeling-and-genome-wide-association
#9
Brigitte Mangin, Pierre Casadebaig, Eléna Cadic, Nicolas Blanchet, Marie-Claude Boniface, Sébastien Carrère, Jérôme Gouzy, Ludovic Legrand, Baptiste Mayjonade, Nicolas Pouilly, Thierry André, Marie Coque, Joël Piquemal, Marion Laporte, Patrick Vincourt, Stéphane Muños, Nicolas B Langlade
Understanding the genetic basis of phenotypic plasticity is crucial for predicting and managing climate change effects on wild plants and crops. Here, we combined crop modeling and quantitative genetics to study the genetic control of oil yield plasticity for multiple abiotic stresses in sunflower. First we developed stress indicators to characterize 14 environments for three abiotic stresses (cold, drought and nitrogen) using the SUNFLO crop model and phenotypic variations of three commercial varieties. The computed plant stress indicators better explain yield variation than descriptors at the climatic or crop levels...
April 18, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28415751/gene-gene-interaction-between-pparg-and-cyp1a1-gene-on-coronary-artery-disease-in-the-chinese-han-population
#10
Xiaojiang Zhang, Shuzheng Lv, Chengjun Guo, Conghong Shi, Yunpeng Chi, Lin Zhao, Guozhong Wang, Zhisheng Wang
AIMS: To observe the influence of the peroxisome proliferator-activator receptor-G (PPAR-G) gene and cytochrome P4501A1 (CYP1A1) single-nucleotide polymorphisms (SNPs), and interactions among several SNPs on coronary artery disease (CAD) risk. METHODS: A total of 1106 participants (including 583 males and 523 females) including 550 CAD patients and 556 control subjects were recruited in this study, and the mean age for these participants was 55.5 ± 11.8 years old...
March 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28409280/critical-issues-in-the-inclusion-of-genetic-and-epigenetic-information-in-prevention-and-intervention-trials
#11
Shawn J Latendresse, Rashelle Musci, Brion S Maher
Human genetic research in the past decade has generated a wealth of data from the genome-wide association scan era, much of which is catalogued and freely available. These data will typically test the relationship between a single nucleotide variant or polymorphism (SNP) and some outcome, disease, or trait. Ongoing investigations will yield a similar wealth of data regarding epigenetic phenomena. These data will typically test the relationship between DNA methylation at a single genomic location/region and some outcome...
April 13, 2017: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/28404909/impact-of-ccl4-gene-polymorphisms-and-environmental-factors-on-oral-cancer-development-and-clinical-characteristics
#12
Ming-Yu Lien, Chiao-Wen Lin, Hsiao-Chi Tsai, Yng-Tay Chen, Ming-Hsui Tsai, Chun-Hung Hua, Shun-Fa Yang, Chih-Hsin Tang
In Taiwan, oral cancer has causally been associated with environmental carcinogens. CCL4 (C-C chemokine ligand 4), a macrophage inflammatory protein with a key role in inflammation and immune-regulation, was implicated in carcinogenesis by facilitating instability in the tumor environment. The purpose of this study was to identify gene polymorphisms of CCL4 specific to patients with oral squamous cell carcinoma (OSCC) susceptibility and clinicopathological characteristics. A total of 2,053 participants, including 1192 healthy people and 861 patients with oral cancer, were recruited for this study...
February 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28403117/association-of-the-ace-gstm1-il-6-nos3-and-cyp1a1-polymorphisms-with-susceptibility-of-mycoplasma-pneumoniae-pneumonia-in-chinese-children
#13
Jie Zhao, Wen Zhang, Li Shen, Xiaomeng Yang, Yi Liu, Zhongtao Gai
Mycoplasma pneumoniae is a common cause of community-acquired pneumonia (CAP) and the clinical presentation of mycoplasma pneumoniae pneumonia (MPP) varies widely. Genetic variability affecting the host response may also influence the susceptibility to MPP. Several studies have investigated the association between single nucleotide polymorphism (SNP) of some genes and the risks of CAP; however, the results were inconsistent. Here, we investigated the association of 5 functional genes and the risks of MPP, including ACE (rs4340), GSTM1 (Ins/del), IL-6 (rs1800795), NOS3 (rs1799983), and CYP1A1 (rs2606345) in a total of 715 subjects (415 cases, 300 controls) by using tetra-primer allele-specific polymerase chain reaction (PCR) and Sanger sequencing...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28402597/gene-gene-interaction-of-single-nucleotide-polymorphisms-in-16p13-3-may-contribute-to-the-risk-of-non-syndromic-cleft-lip-with-or-without-cleft-palate-in-chinese-case-parent-trios
#14
Dongjing Liu, Hong Wang, Holger Schwender, Mary L Marazita, Zhuqing Wang, Yuan Yuan, Ping Wang, Kung Yee Liang, Yah Huei Wu-Chou, Mengying Wang, Bing Shi, Hongping Zhu, Tao Wu, Terri H Beaty
Non-syndromic cleft lip with or without cleft palate (NSCL/P) is a common birth defect with a complex and heterogeneous etiology. A recent genome-wide association study (GWAS) among Chinese populations has identified a new region at 16p13.3 as being associated with NSCL/P, which requires further replication. Here, we attempted to replicate and further clarify the genetic association between this region and NSCL/P, as well as testing for potential gene-gene (G × G) and gene-environment (G × E) interactions...
April 12, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28400492/the-molecular-dialog-between-flowering-plant-reproductive-partners-defined-by-snp-informed-rna-sequencing
#15
Alexander R Leydon, Caleb Weinreb, Elena Venable, Anke Reinders, John M Ward, Mark A Johnson
The molecular interactions between reproductive cells are critical for determining whether sexual reproduction between individuals results in fertilization and can result in barriers to interspecific hybridization. However, it is a challenge to define the complete molecular exchange between reproductive partners because parents contribute to a complex mixture of cells during reproduction. We unambiguously defined male- and female-specific patterns of gene expression during Arabidopsis reproduction using single nucleotide polymorphism-informed RNA-seq analysis...
April 11, 2017: Plant Cell
https://www.readbyqxmd.com/read/28400480/combined-genetic-biomarkers-and-betel-quid-chewing-for-identifying-high-risk-group-for-oral-cancer-occurrence
#16
Chia-Min Chung, Chien-Hung Lee, Mu-Kuan Chen, Ka-Wo Lee, Cheng-Che E Lan, Aij-Lie Kwan, Ming-Hsui Tsai, Ying-Chin Ko
We integrated genetic risk scores (GRS) and environmental factors for identifying high risk subjects for oral squamous cell carcinoma (OSCC) occurrence by using case - control study. A total of 447 patients diagnosed with OSCC and 580 unrelated subjects were recruited from two medical centers in Taiwan. A multinomial logistic regression model was conducted to access interaction between genetic risk score and Betel quid (BQ) chewing. We employed receiver operating characteristic (ROC) curve to compare the accuracy of OSCC occurrence...
April 11, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28399564/interactions-between-genome-wide-significant-genetic-variants-and-circulating-concentrations-of-25-hydroxyvitamin-d-in-relation-to-prostate-cancer-risk-in-the-national-cancer-institute-bpc3
#17
Vasiliki I Dimitrakopoulou, Ruth C Travis, Irene M Shui, Alison Mondul, Demetrius Albanes, Jarmo Virtamo, Antonio Agudo, Heiner Boeing, H Bas Bueno-de-Mesquita, Marc J Gunter, Mattias Johansson, Kay-Tee Khaw, Kim Overvad, Domenico Palli, Antonia Trichopoulou, Edward Giovannucci, David J Hunter, Sara Lindström, Walter Willett, J Michael Gaziano, Meir Stampfer, Christine Berg, Sonja I Berndt, Amanda Black, Robert N Hoover, Peter Kraft, Timothy J Key, Konstantinos K Tsilidis
Genome-wide association studies (GWAS) have identified over 100 single nucleotide polymorphisms (SNPs) associated with prostate cancer. However, information on the mechanistic basis for some associations is limited. Recent research has been directed towards the potential association of vitamin D concentrations and prostate cancer, but little is known about whether the aforementioned genetic associations are modified by vitamin D. We investigated the associations of 46 GWAS-identified SNPs, circulating concentrations of 25-hydroxyvitamin D (25(OH)D), and prostate cancer (3,811 cases, 511 of whom died from the disease, compared with 2,980 controls-from 5 cohort studies that recruited participants over several periods beginning in the 1980s)...
March 15, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28395858/association-between-exposure-to-organochlorine-compounds-and-maternal-thyroid-status-role-of-the-iodothyronine-deiodinase-1-gene
#18
Sabrina Llop, Mario Murcia, Mar Alvarez-Pedrerol, Joan O Grimalt, Loreto Santa-Marina, Jordi Julvez, Fernando Goñi-Irigoyen, Mercedes Espada, Ferran Ballester, Marisa Rebagliato, Maria-Jose Lopez-Espinosa
INTRODUCTION: Exposure to organochlorine compounds (OCs) may interfere with thyroid hormone (TH) homeostasis. The disruption of the deiodinase (DIO) enzymes has been proposed as a mechanism of action. AIM: To evaluate the association between exposure to OCs and TH status in pregnant women, as well as to explore the role of genetic variations in the DIO1 and DIO2 genes. METHODS: The study population (n=1128) was composed of pregnant women who participated in the INMA Project (Spain, 2003-2006)...
April 8, 2017: Environment International
https://www.readbyqxmd.com/read/28393910/genetic-dissection-of-seed-oil-and-protein-content-and-identification-of-networks-associated-with-oil-content-in-brassica-napus
#19
Hongbo Chao, Hao Wang, Xiaodong Wang, Liangxing Guo, Jianwei Gu, Weiguo Zhao, Baojun Li, Dengyan Chen, Nadia Raboanatahiry, Maoteng Li
High-density linkage maps can improve the precision of QTL localization. A high-density SNP-based linkage map containing 3207 markers covering 3072.7 cM of the Brassica napus genome was constructed in the KenC-8 × N53-2 (KNDH) population. A total of 67 and 38 QTLs for seed oil and protein content were identified with an average confidence interval of 5.26 and 4.38 cM, which could explain up to 22.24% and 27.48% of the phenotypic variation, respectively. Thirty-eight associated genomic regions from BSA overlapped with and/or narrowed the SOC-QTLs, further confirming the QTL mapping results based on the high-density linkage map...
April 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28393844/long-noncoding-rna-linc00305-promotes-inflammation-by-activating-the-ahrr-nf-%C3%AE%C2%BAb-pathway-in-human-monocytes
#20
Dan-Dan Zhang, Wen-Tian Wang, Jian Xiong, Xue-Min Xie, Shen-Shen Cui, Zhi-Guo Zhao, Mulin Jun Li, Zhu-Qin Zhang, De-Long Hao, Xiang Zhao, Yong-Jun Li, Junwen Wang, Hou-Zao Chen, Xiang Lv, De-Pei Liu
Accumulating data from genome-wide association studies (GWAS) have provided a collection of novel candidate genes associated with complex diseases, such as atherosclerosis. We identified an atherosclerosis-associated single-nucleotide polymorphism (SNP) located in the intron of the long noncoding RNA (lncRNA) LINC00305 by searching the GWAS database. Although the function of LINC00305 is unknown, we found that LINC00305 expression is enriched in atherosclerotic plaques and monocytes. Overexpression of LINC00305 promoted the expression of inflammation-associated genes in THP-1 cells and reduced the expression of contractile markers in co-cultured human aortic smooth muscle cells (HASMCs)...
April 10, 2017: Scientific Reports
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