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https://www.readbyqxmd.com/read/28631614/3d-printed-bioceramic-scaffolds-with-antibacterial-and-osteogenic-activity
#1
Yongliang Zhang, Dong Zhai, Mengchi Xu, Qingqiang Yao, Huiying Zhu, Jiang Chang, Chengtie Wu
Bacterial infection poses a significant risk with the wide application of bone graft materials. Designing bone grafts with good antibacterial performance and excellent bone-forming activity is of particular significance for bone tissue engineering. In our study, a 3D printing method was used to prepare β-tricalcium phosphate (β-TCP) bioceramic scaffolds. Silver (Ag) nanoparticles were uniformly dispersed on graphene oxide (GO) to form a homogeneous nanocomposite (named Ag@GO) with different Ag-to-graphene oxide mass ratios, with this being synthesized via the liquid chemical reduction approach...
June 20, 2017: Biofabrication
https://www.readbyqxmd.com/read/28629069/evaluation-of-electrospun-biomimetic-substrate-surface-decorated-with-nanohydroxyapatite-precipitation-for-osteoblasts-behavior
#2
Sai Zhang, Guojun Jiang, Molamma P Prabhakaran, Xiaohong Qin, Seeram Ramakrishna
To engineer bone tissue, it is crucial to design scaffolds with micro- and nano-sized architecture imitating approximate hierarchical structure of native bone, and afford desirable biological properties by introducing biocompatible polymers and bioceramics into the scaffolds. Here, a novel scaffold consisting of poly-3-hydroxybutyrate-co-3-hydroxyvalerate (PHBV)/polyaspartic acid (PAA) was fabricated by electrospinning and nano-hydroxyapatite (nHA) was deposited by calcium-phosphate dipping process for bone tissue regeneration...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28620190/formation-of-biphasic-hydroxylapatite-beta-magnesium-tricalcium-phosphate-in-heat-treated-salmonid-vertebrae
#3
Don H Butler, Ruth Shahack-Gross
Ichthyoarchaeological evidence is uncommon at ancient hunter-gatherer sites from various regions and timeframes. This research contributes to the development of microarchaeological techniques useful for identifying fishing economies in situations where classifiable bones are unavailable. Specifically, traces of heat altered bone mineral in domestic hearths are expected to provide markers for discarded fish remains. We used a series of laboratory incineration experiments to characterize the mineralogy of burned salmonid vertebrae...
June 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28616254/in-vitro-ion-adsorption-and-cytocompatibility-of-dicalcium-phosphate-ceramics
#4
Martha Schamel, Jake E Barralet, Jürgen Groll, Uwe Gbureck
BACKGROUND: In vitro cell testing of degradable bioceramics such as brushite or monetite is often challenging due to the ion release into or adsorption from the culture medium. These ionic changes are then mostly responsible for cell proliferation and activity, which prohibits the investigation of effects originating from surface topography or further material modifications. METHODS: Here, we aimed to solve this problem by developing a pre-conditioning regime following the repeated immersion of brushite and monetite samples in various Ca(2+), Mg(2+) and PO4(3-) containing electrolytes, followed by studying ion adsorption / release as well as changes in phase composition and in vitro cytocompatibility with MG63 cells...
2017: Biomaterials Research
https://www.readbyqxmd.com/read/28600540/electric-field-assisted-3d-fibrous-bioceramic-based-scaffolds-for-bone-tissue-regeneration-fabrication-characterization-and-in-vitro-cellular-activities
#5
Minseong Kim, Hui-Suk Yun, Geun Hyung Kim
Nano/microfibrous structure can induce high cellular activities because of the topological similarity of the extracellular matrix, and thus, are widely used in various tissue regenerative materials. However, the fabrication of a bioceramic (high weight percent)-based 3D microfibrous structure is extremely difficult because of the low process-ability of bioceramics. In addition, three-dimensional (3D) microfibrous structure can induce more realistic cellular behavior when compared to that of 2D fibrous structure...
June 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28600538/an-innovative-cell-laden-%C3%AE-tcp-collagen-scaffold-fabricated-using-a-two-step-printing-process-for-potential-application-in-regenerating-hard-tissues
#6
Won Jin Kim, Hui-Suk Yun, Geun Hyung Kim
Cell-laden scaffolds are widely investigated in tissue engineering because they can provide homogenous cell distribution after long culture periods, and deposit multiple types of cells into a designed region. However, producing a bioceramic 3D cell-laden scaffold is difficult because of the low processability of cell-loaded bioceramics. Therefore, designing a 3D bioceramic cell-laden scaffold is important for ceramic-based tissue regeneration. Here, we propose a new strategy to fabricate an alpha-tricalcium-phosphate (α-TCP)/collagen cell-laden scaffold, using preosteoblasts (MC3T3-E1), in which the volume fraction of the ceramic exceeded 70% and was fabricated using a two-step printing process...
June 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28576047/optimally-designed-collagen-polycaprolactone-biocomposites-supplemented-with-controlled-release-of-ha-tcp-rhbmp-2-and-ha-tcp-prp-for-hard-tissue-regeneration
#7
WonJin Kim, Chul Ho Jang, GeunHyung Kim
Collagen has been widely used as a very promising material to regenerate various tissues. It is a chief component of the extracellular matrix, and encourages various biological effects conducive to tissue regeneration. However, poor mechanical stability, low processability, and high level of water absorption can lead to impaired control of growth factor release and have impeded the use of collagen as a functional biomedical scaffold. Here, to overcome the shortcomings of collagen scaffolds, we have additively manufactured collagen/polycaprolactone (PCL) biocomposites supplemented with a bioceramic (hydroxyapatite (HA)/β-tricalcium-phosphate (TCP)) and two growth factors (recombinant human bone morphogenetic protein-2 [rhBMP-2] and platelet-rich plasma [PRP])...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28559709/comparative-radiographic-assessment-of-a-new-bioceramic-based-root-canal-sealer
#8
Dana Hrab, Andrea Maria Chisnoiu, Mindra Eugenia Badea, Marioara Moldovan, Radu Marcel Chisnoiu
BACKGROUND AND AIMS: The aim of this study was to assess the radiopacity of two bioceramic-based root canal sealers, the conventional TotalFill BC sealer (FKG Dentaire Switzerland) and a new experimental filling material developed in collaboration with 'Raluca Ripan' Institute for Research in Chemistry, Cluj-Napoca. METHODS: Five disc samples were prepared using both materials (10 mm diameter × 1 mm thickness), being subjected to digital radiography together with aluminum step wedges (1 to 12 mm in thickness), in accordance with ISO 6876: 2012...
2017: Clujul Medical (1957)
https://www.readbyqxmd.com/read/28544592/direct-influence-of-titanium-and-zirconia-particles-on-the-morphology-and-functionality-of-mature-human-osteoclasts
#9
Juliane Pasold, Jana Markhoff, Jenny Tillmann, Martin Krogull, Phillip Pisowocki, Rainer Bader
Within the last ten years of biomedical implants, the focus is increasingly on bioceramics, specifically on zirconia (ZrO2 ). Hence, we analyzed the impact of ZrO2 particles in comparison to titanium particles on mature human osteoclasts (OCs) as little is known about the direct effect of wear particles on mature OCs and their role in the osteolytic process during aseptic endoprosthesis loosening. Changes in cell morphology and functionality of OCs incubated with particles in different concentrations were investigated in vitro...
May 22, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28531999/zro2-toughened-al2o3-based-near-net-shaped-femoral-head-unique-fabrication-approach-3d-microstructure-burst-strength-and-muscle-cell-response
#10
Debasish Sarkar, Sourav Mandal, B S Reddy, Nitu Bhaskar, D C Sundaresh, Bikramjit Basu
The development of reliable biomedical devices demands the use of an integrated manufacturing protocol with comprehensive understanding of prototype characterization in terms of 3D microstructural analysis along with biocompatibility. While addressing these issues for ZrO2 (3mol% Y2O3 stabilized)-toughened Al2O3-based femoral head prototypes, the present work reports a unique fabrication protocol involving a sequence of uniaxial compaction followed by pre-sintering, machining, final sintering and polishing to ensure dimensional tolerance with respect to the design of patient-specific femoral head...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28527187/quantitative-stereological-analysis-of-the-highly-porous-hydroxyapatite-scaffolds-using-x-ray-cm-and-sem
#11
Justyna Zygmuntowicz, Aneta Zima, Joanna Czechowska, Karol Szlazak, Anna Ślosarczyk, Katarzyna Konopka
BACKGROUND: Material properties of the scaffolds as well as their microstructure are vital in determining in vivo cellular response. Three-dimensional (3D), highly porous scaffolds are used in tissue engineering to provide a suitable microenvironment and to support regeneration of bone. Both pore sizes and their architecture, in particular interconnection density, impact functionality of scaffold during its biomedical applications. OBJECTIVE: In this paper a comparative study of the microstructure of highly porous hydroxyapatite scaffolds produced via gelcasting of foamed slurries and replication of polyurethane sponge were carried out...
2017: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/28512480/effect-of-intra-canal-calcium-hydroxide-remnants-on-the-push-out-bond-strength-of-two-endodontic-sealers
#12
Sholeh Ghabraei, Behnam Bolhari, Fatemeh Yaghoobnejad, Naghmeh Meraji
INTRODUCTION: The aim of this study was to evaluate the effect of intra-canal calcium hydroxide (CH) remnants after ultrasonic irrigation and hand file removal on the push out bond strength of AH-26 and EndoSequence Bioceramic sealer (BC Sealer). METHODS AND MATERIALS: A total of 102 single-rooted extracted human teeth were used in this study. After root canal preparation up to 35/0.04 Mtwo rotary file, all the specimens received CH dressing except for 34 specimens in the control group...
2017: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/28506609/ageing-kinetics-and-strength-of-airborne-particle-abraded-3y-tzp-ceramics
#13
Jasna Cotič, Peter Jevnikar, Andraž Kocjan
OBJECTIVE: The combined effects of alumina airborne-particle abrasion and prolonged in vitro ageing on the flexural strength of 3Y-TZP ceramic have been studied. The aim was to identify the different effects on the surface and subsurface regions that govern the performance of this popular bioceramic known for its susceptibility to low-temperature degradation (LTD). METHODS: As-sintered or airborne-particle abraded 3Y-TZP discs were subjected to ageing at 134°C for up to 480h...
May 12, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28500666/bioactivity-and-mineralization-of-natural-hydroxyapatite-from-cuttlefish-bone-and-bioglass%C3%A2-co-sintered-bioceramics
#14
Natascia Cozza, Felipe Monte, Walter Bonani, Pranesh Aswath, Antonella Motta, Claudio Migliaresi
In this study, bioactive hydroxyapatite-based bioceramics starting from cuttlefish bone powders have been prepared and characterized. In particular, fragmented cuttlefish bone was co-sintered with 30 wt% of Bioglass®-45S5 to synthesize hydroxyapatite-based powders with enhanced mechanical properties and bioactivity. Commercial synthetic hydroxyapatite was treated following the same procedure and used as a reference. The structure and composition of the bioceramics formulations were characterized using Fourier transform infrared spectroscopy, X-ray diffraction and scanning electron microscopy...
May 13, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28499127/3d-printed-scaffolds-with-synergistic-effect-of-hollow-pipe-structure-and-bioactive-ions-for-vascularized-bone-regeneration
#15
Wenjie Zhang, Chun Feng, Guangzheng Yang, Guanglong Li, Xun Ding, Shaoyi Wang, Yuandong Dou, Zhiyuan Zhang, Jiang Chang, Chengtie Wu, Xinquan Jiang
Segmental bone regeneration remains a considerable challenge due to the associated low degree of vascularization. To solve this problem, in this study, hollow-pipe-packed silicate bioceramic (BRT-H) scaffolds are fabricated using a coaxial three-dimensional (3D) printing technique. Based on a modified core/shell printer nozzle and a modulated viscoelastic bioceramic paste, hollow struts with an external diameter of 1 mm and internal dimeter of 500 μm can be directly printed, yielding a compressive strength of the BRT-H scaffolds as high as 26 MPa...
May 3, 2017: Biomaterials
https://www.readbyqxmd.com/read/28494372/separation-and-preconcentration-of-riboflavin-from-human-plasma-using-polythionine-coated-magnetite-hydroxyapatite-nanocomposite-prior-to-analysis-by-surfactant-enhanced-fluorimetry
#16
Leila Farzin, Mojtaba Shamsipur
The exploration of novel adsorption properties of conductive polymers based on hybridization with biocompatible nanomaterials receives an increasing interest. In this regard, hydroxyapatite (HA) bioceramic is of critical importance mainly owing to its facile synthesis, high surface area, economic and low toxicity in biological environments. In this work, we first prepared and characterized a magnetite/hydroxyapatite (Fe3O4/HA) nanocomposite using the bio-waste chicken eggshell via an attractive green way that involved low cost and irrespective of toxicity...
May 2, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28483692/biocompatible-nanostructured-solid-adhesives-for-biological-soft-tissues
#17
Masahiro Okada, Akira Nakai, Emilio Satoshi Hara, Tetsushi Taguchi, Takayoshi Nakano, Takuya Matsumoto
Over the past few years, the development of novel adhesives for biological soft tissue adhesion has gained significant interest. Such adhesives should be non-toxic and biocompatible. In this study, we synthesized a novel solid adhesive using nanostructured hydroxyapatite (HAp) and evaluated its physical adhesion properties through in vitro testing with synthetic hydrogels and mice soft tissues. The results revealed that the HAp-nanoparticle dispersions and HAp-nanoparticle-assembled nanoporous plates showed efficient adhesion to the hydrogels...
May 5, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28482616/hydroxyapatite-bioceramic-with-large-porosity
#18
M Mbarki, P Sharrock, M Fiallo, H ElFeki
Calcium phosphate based biomaterials have been used as bone graft with great success in the last decade. This material is employed in orthopedic and dental applications depending on their specific properties. In this work, we made a bioceramic with a large porosity, then we measured porosity, density and compressive strength of HA bioceramic. The SEM analysis was performed to show the morphology of the structure. The mechanical properties depend on the sintering of the HA bioceramic and the amount of pores...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28461922/bone-grafts-bone-graft-extenders-substitutes-and-enhancers-for-acetabular-reconstruction-in-revision-total-hip-arthroplasty
#19
REVIEW
Luca Pierannunzii, Luigi Zagra
Acetabular bone loss is a relevant concern for surgeons dealing with a failed total hip arthroplasty.Since the femoral head is no longer available, allografts represent the first choice for most reconstructive solutions, either as a structural buttress or impacted bone chips.Even though fresh-frozen bone is firmly recommended for structural grafts, freeze-dried and/or irradiated bone may be used alternatively for impaction grafting. Indeed, there are some papers on freeze-dried or irradiated bone impaction grafting, but their number is limited, as is the number of cases...
December 2016: EFORT open reviews
https://www.readbyqxmd.com/read/28438865/effect-of-hydrogen-dioxide-treatment-on-the-osteogenic-potential-of-duck-beak-bone-derived-natural-bioceramic-microparticles
#20
Joong-Hyun Kim, Min-Ho Park, Seok Jin Jang, Soo Jin Son, Jae Yeon Lee, Jun Sik Son, Se Eun Kim, Seong Soo Kang, Seok Hwa Choi
As an alternative material to the autogenous bone, duck-beak bone particle for bone substitute have been attracting great attention due to their biological properties. To deliver the most favorable outcome of medical treatment, it is essential to study the effect of various processing methods of the duck-beak bone. In this study, we compared the two deproteinizing agents for manufacturing duck-beak bone. Group 1 was treated by a conventional chemical agent (ethylenediamine) and Group 2 by hydrogen dioxide (H2O2)...
May 2017: In Vivo
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