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https://www.readbyqxmd.com/read/28917940/natural-and-synthetic-polymers-bioceramics-bioactive-compounds-mediated-cell-signaling-in-bone-tissue-engineering
#1
REVIEW
S Harsha Rao, B Harini, R Pranav Kumar Shadamarshan, K Balagangadharan, N Selvamurugan
Bone is a highly integrative and dynamic tissue of the human body. It is continually remodeled by bone cells such as osteoblasts, osteoclasts. When a fraction of a bone is damaged or deformed, stem cells and bone cells under the influence of several signaling pathways regulate bone regeneration at the particular locale. Effective therapies for bone defects can be met via bone tissue engineering which employs drug delivery systems with biomaterials to enhance cellular functions by acting on signaling pathways such as Wnt, BMP, TGF-β, and Notch...
September 13, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28882956/osteochondral-repair-using-porous-three-dimensional-nanocomposite-scaffolds-in-a-rabbit-model
#2
Beata Żylińska, Ewa Stodolak-Zych, Aleksandra Sobczyńska-Rak, Tomasz Szponder, Piotr Silmanowicz, Mirosław Łańcut, Łukasz Jarosz, Paweł Różański, Izabela Polkowska
AIM: To evaluate the utility of a novel nanocomposite biomaterial consisting of poly-L/D-lactide, and hydroxyapatite bioceramics, enriched with sodium alginate in articular cartilage defect treatment. MATERIALS AND METHODS: The biomaterial was prepared using the method of solvent casting and particle leaching. The study was conducted on 20 New Zealand White rabbits. Experimental osteochondral defects were created in the femoral trochlear grooves and filled with biomaterials...
September 2017: In Vivo
https://www.readbyqxmd.com/read/28877288/effect-of-rewetting-solutions-on-micropush-out-dentin-bond-strength-of-new-bioceramic-endodontic-material
#3
Giovana Cunha Gritti, Salma Ivanna Araújo Cavalcante, Etevaldo Matos Maia-Filho, José Bauer, Matheus Coêlho Bandéca, Giulio Gavini, Ceci Nunes Carvalho
To evaluate the influence of rewetting solutions on bond strength to root dentin of conventional gutta-percha (GP) or niobium phosphate glass-based gutta-percha (GNb) associated with a bioceramic sealer. The root canals of 80 human mandibular premolars were prepared using nickel-titanium instruments and irrigation with sodium hypochlorite and EDTA. The teeth were randomly divided into four groups according to the gutta-percha used: GNb or GP associated with EndoSequence BC Sealer (BC) and the solution for rewetting dentin before filling (distilled water; phosphate buffer saline solution - PBS; simulated body fluid - SBF; or no solution)...
August 31, 2017: Brazilian Oral Research
https://www.readbyqxmd.com/read/28865173/the-extracts-of-bredigite-bioceramics-enhanced-the-pluripotency-of-human-dental-pulp-cellss
#4
Lihong Chen, Lu Liu, Chengtie Wu, Ruiqi Yang, Jiang Chang, Xi Wei
Biomaterials have a profound effect on tissue engineering and regenerative medicine, but few studies have reported the role of extracts from bioceramics in the regulation of stem cell pluripotency. The present study investigated the effects of bioceramics extracts, including silicate bredigite (Ca7 MgSi4 O16 ) and conventional β-tricalcium phosphate (β-TCP), on the pluripotency and the multilineage differentiation potential of human dental pulp cells (hDPCs). Basic fibroblast growth factor (bFGF), which is a known regulator of hDPCs pluripotency, was used as a reference...
September 2, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28864248/regulation-of-immune-response-by-bioactive-ions-released-from-silicate-bioceramics-for-bone-regeneration
#5
Yan Huang, Chengtie Wu, Xiaoling Zhang, Jiang Chang, Kerong Dai
Silicate bioceramics have been considered to possess a wide prospect of clinical application for orthopedic tissue regeneration due to their excellent osteogenesis and angiogenesis. However, the mechanism for silicate bioceramics stimulating bone formation is not fully understood. The host immune defense to implants is proved to greatly influence the osteogenesis and new bone formation, but up to now, few studies are focused on the silicate bioceramics modulated host immune responses. In our present study, two representative silicate bioceramics, akermanite (AKT) and nagelschmidtite (NAGEL) were used as model materials to investigate the inflammation responses in vitro and in vivo, and β-tricalcium phosphate (β-TCP) bioceramics were used as a control...
August 29, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28851519/bioactive-glass-ceramic-nanoparticles-coated-poly-l-lactic-acid-scaffold-improved-osteogenic-differentiation-of-adipose-stem-cells-in-equine
#6
Fatemeh Sadat Mahdavi, Abdolreza Salehi, Ehsan Seyedjafari, Abdollah Mohammadi-Sangcheshmeh, Abdolreza Ardeshirylajimi
Horses with big bone fractures have low chance to live mainly due to the lake of a proper treatment strategy. We believe that further attempts in equine bone tissue engineering will probably be required to meet all the needs for the lesion therapies. Therefore in this study we aimed to investigate the osteogenic differentiation capacity of equine adipose-derived stem cells (e-ASCs) on nano-bioactive glass (nBGs) coated poly(l-lactic acid) (PLLA) nanofibers scaffold (nBG-PLLA). Using electrospinning technique, PLLA scaffold was prepared successfully and coated with nBGs...
July 20, 2017: Tissue & Cell
https://www.readbyqxmd.com/read/28808463/micro-push-out-bond-strength-and-bioactivity-analysis-of-a-bioceramic-root-canal-sealer
#7
Ceci Nunes Carvalho, Renata Grazziotin-Soares, George Táccio de Miranda Candeiro, Luis Gallego Martinez, Juliana Pereira de Souza, Patrícia Santos Oliveira, José Bauer, Giulio Gavini
INTRODUCTION: Bioactive endodontic sealers have been developed to improve the quality of root canal obturation. EndoSequence Bioceramic (BC) Sealer is amongst calcium silicate-based materials recently developed for permanent root canal filling. The objective of this study was to evaluate the bioactivity of BC Sealer and its micro push-out bond strength to dentin compared to AH-Plus (AH) sealer. METHODS AND MATERIALS: To perform the micro push-out test, 24 root canals of mandibular premolars were instrumented and divided into two groups (n=12)...
2017: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/28807800/the-synergistic-effects-of-sr-and-si-bioactive-ions-on-osteogenesis-osteoclastogenesis-and-angiogenesis-for-osteoporotic-bone-regeneration
#8
Lixia Mao, Lunguo Xia, Jiang Chang, Jiaqiang Liu, Lingyong Jiang, Chengtie Wu, Bing Fang
Bioactive ions released from bioceramics play important roles in bone regeneration; however, it is unclear how each ionic composition in complex bioceramics exerts its specific effect on bone regeneration. The aim of this study is to elucidate the functional effects of Sr and Si ions in bioceramics on the regeneration of osteoporotic bone. A model bioceramic with Sr- and Si-containing components (SMS) was successfully fabricated and the effects of ionic products from SMS bioceramics on the osteogenic, osteoclastic and angiogenic differentiation of rBMSCs-OVX and RANKL-induced osteoclasts were investigated...
August 12, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28807799/the-influence-of-yttrium-segregation-dependent-phase-partitioning-and-residual-stresses-on-the-aging-and-fracture-behaviour-of-3y-tzp-ceramics
#9
Dušan Bučevac, Tomaž Kosmač, Andraž Kocjan
The yttrium-segregation-dependent phase partitioning and residual stress development that influence both the aging and the fracture behaviour in 3Y-TZP bioceramics were studied by sintering alumina-free 3Y-TZP, varying the sintering temperature and the time, to yield ceramics with identical grain size distributions, but with different phase compositions. The structure and stability of the resulting tetragonal phases, in the form of transformable, yttria-lean t-ZrO2 (YLZ) and non-transformable, yttria-rich t"-ZrO2 and/or t'-ZrO2 (YRZ), were studied by X-ray diffraction (XRD) and focused ion beam scanning electron microscopy (FIB-SEM)...
August 11, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28807371/treatment-outcome-following-direct-pulp-capping-using-bioceramic-materials-in-mature-permanent-teeth-with-carious-exposure-a%C3%A2-pilot%C3%A2-retrospective-study
#10
S Linu, M S Lekshmi, V S Varunkumar, V G Sam Joseph
INTRODUCTION: The aim of this study was to investigate the sequelae of direct pulp capping (DPC) using mineral trioxide aggregate (MTA) and Biodentine in mature permanent teeth with carious exposure. METHODS: Clinical records of 30 patients (15 each with MTA and Biodentine) treated with DPC technique from January 2015 to June 2015 were retrieved. Success rates (based on symptoms, sensibility tests, and radiographic analysis) and adverse events were analyzed. RESULTS: The patients were reviewed at 1, 3, 6, 12, and 18 months after treatment...
August 11, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28806647/mechanical-reinforcement-of-bioceramics-scaffolds-via-fracture-energy-dissipation-induced-by-sliding-action-of-mos2-nanoplatelets
#11
Cijun Shuai, Hang Sun, Chengde Gao, Pei Feng, Wang Guo, Youwen Yang, Mingchun Zhao, Sheng Yang, Fulai Yuan, Shuping Peng
The inherent brittleness of bioceramics restricts their applications in load bearing implant, although they possess good biocompatibility and bioactivity. In this study, molybdenum disulfide nanoplatelets (MSNPs) were used to reinforce bioceramics (Mg2SiO4/CaSiO3) scaffolds fabricated by selective laser sintering (SLS). The fracture mode of scaffolds was transformed from transgranular to mixed trans- and intergranular. It could be explained that MSNPs could slide easily due to their weak interlayer van der Waals interactions and provide elastic deformation due to their high elastic modulus...
July 20, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28799674/ultrastructural-characteristics-of-ovine-bone-marrow-derived-mesenchymal-stromal-cells-cultured-with-a-silicon-stabilized-tricalcium-phosphate-bioceramic
#12
Salvatore Desantis, Gianluca Accogli, Janina Burk, Sara Zizza, Maria Mastrodonato, Edda G Francioso, Roberta Rossi, Antonio Crovace, Leonardo Resta
Bioceramics are being used in experimental bone engineering application in association with bone marrow derived mesenchymal stem cells (BM-MSCs) as a new therapeutic tool, but their effects on the ultrastructure of BM-MSCs are yet unknown. In this study we report the morphological features of ovine (o)BM-MSCs cultured with Skelite, a resorbable bioceramic based on silicon stabilized tricalcium phosphate (SiTCP), able to promote the repair of induced bone defect in sheep model. oBM-MSCs were isolated from the iliac crest, cultured until they reached near-confluence and incubated with SiTCP...
August 11, 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/28794848/bioactive-calcium-phosphate-based-glasses-and-ceramics-and-their-biomedical-applications-a-review
#13
Md Towhidul Islam, Reda M Felfel, Ensanya A Abou Neel, David M Grant, Ifty Ahmed, Kazi M Zakir Hossain
An overview of the formation of calcium phosphate under in vitro environment on the surface of a range of bioactive materials (e.g. from silicate, borate, and phosphate glasses, glass-ceramics, bioceramics to metals) based on recent literature is presented in this review. The mechanism of bone-like calcium phosphate (i.e. hydroxyapatite) formation and the test protocols that are either already in use or currently being investigated for the evaluation of the bioactivity of biomaterials are discussed. This review also highlights the effect of chemical composition and surface charge of materials, types of medium (e...
January 2017: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/28774105/strontium-substituted-bioceramics-particles-a-new-way-to-modulate-mcp-1-and-gro-%C3%AE-production-by-human-primary-osteoblastic-cells
#14
Julien Braux, Frédéric Velard, Christine Guillaume, Marie-Laure Jourdain, Sophie C Gangloff, Edouard Jallot, Jean-Marie Nedelec, Patrice Laquerrière, Dominique Laurent-Maquin
BACKGROUND: To avoid morbidity and limited availability associated with autografts, synthetic calcium phosphate (CaP) ceramics were extensively developed and used as bone filling materials. Controlling their induced-inflammatory response nevertheless remained a major concern. Strontium-containing CaP ceramics were recently demonstrated for impacting cytokines' secretion pattern of human primary monocytes. The present study focuses on the ability of strontium-containing CaP to control the human primary bone cell production of two major inflammatory and pro-osteoclastogenic mediators, namely MCP-1 and Gro-α, in response to ceramics particles...
December 5, 2016: Materials
https://www.readbyqxmd.com/read/28774090/assessment-of-effects-of-si-ca-p-biphasic-ceramic-on-the-osteogenic-differentiation-of-a-population-of-multipotent-adult-human-stem-cells
#15
Patricia Ros-Tárraga, Rubén Rabadan-Ros, Angel Murciano, Luis Meseguer-Olmo, Piedad N De Aza
A new type of bioceramic with osteogenic properties, suitable for hard tissue regeneration, was synthesised. The ceramic was designed and obtained in the Nurse's A-phase-silicocarnotite subsystem. The selected composition was that corresponding to the eutectoid 28.39 wt % Nurse's A-phase-71.61 wt % silicocarnotite invariant point. We report the effect of Nurse's A-phase-silicocarnotite ceramic on the capacity of multipotent adult human mesenchymal stem cells (ahMSCs) cultured under experimental conditions, known to adhere, proliferate and differentiate into osteoblast lineage cells...
November 29, 2016: Materials
https://www.readbyqxmd.com/read/28772783/the-in-vitro-bioactivity-degradation-and-cytotoxicity-of-polymer-derived-wollastonite-diopside-glass-ceramics
#16
Amanda De Castro Juraski, Andrea Cecilia Dorion Rodas, Hamada Elsayed, Enrico Bernardo, Viviane Oliveira Soares, Juliana Daguano
Ca-Mg silicates are receiving a growing interest in the field of bioceramics. In a previous study, wollastonite-diopside (WD) glass-ceramics were successfully prepared by a new processing route, consisting of the heat treatment of a silicone resin embedding reactive oxide particles and a Ca/Mg-rich glass. The in vitro degradation, bioactivity, and cell response of these new WD glass-ceramics, fired at 900-1100 °C for 1 h, as a function of the Ca/Mg-rich glass content, are the aim of this investigation The results showed that WD glass-ceramics from formulations comprising different glass contents (70-100% at 900 °C, 30% at 1100 °C) exhibit the formation of an apatite-like layer on their surface after immersion in SBF for seven days, thus confirming their surface bioactivity...
April 18, 2017: Materials
https://www.readbyqxmd.com/read/28772697/calcium-phosphate-bioceramics-a-review-of-their-history-structure-properties-coating-technologies-and-biomedical-applications
#17
REVIEW
Noam Eliaz, Noah Metoki
Calcium phosphate (CaP) bioceramics are widely used in the field of bone regeneration, both in orthopedics and in dentistry, due to their good biocompatibility, osseointegration and osteoconduction. The aim of this article is to review the history, structure, properties and clinical applications of these materials, whether they are in the form of bone cements, paste, scaffolds, or coatings. Major analytical techniques for characterization of CaPs, in vitro and in vivo tests, and the requirements of the US Food and Drug Administration (FDA) and international standards from CaP coatings on orthopedic and dental endosseous implants, are also summarized, along with the possible effect of sterilization on these materials...
March 24, 2017: Materials
https://www.readbyqxmd.com/read/28772452/first-row-transition-metal-doping-in-calcium-phosphate-bioceramics-a-detailed-crystallographic-study
#18
Guillaume Renaudin, Sandrine Gomes, Jean-Marie Nedelec
Doped calcium phosphate bioceramics are promising materials for bone repair surgery because of their chemical resemblance to the mineral constituent of bone. Among these materials, BCP samples composed of hydroxyapatite (Ca10(PO₄)₆(OH)₂) and β-TCP (Ca₃(PO₄)₂) present a mineral analogy with the nano-multi-substituted hydroxyapatite bio-mineral part of bones. At the same time, doping can be used to tune the biological properties of these ceramics. This paper presents a general overview of the doping mechanisms of BCP samples using cations from the first-row transition metals (from manganese to zinc), with respect to the applied sintering temperature...
January 23, 2017: Materials
https://www.readbyqxmd.com/read/28761974/dicalcium-phosphate-anhydrous-an-appropriate%C3%A2-bioceramic-in-regeneration-of-critical-sized-radial-bone-defects-in-rats
#19
Ahmad Oryan, Soodeh Alidadi, Amin Bigham-Sadegh
The present study aimed to evaluate and compare the effectiveness of composites of calcium phosphates including β-tri calcium phosphate (β-TCP), dicalcium phosphate anhydrous (DCPA, monetite), mono-calcium phosphate monohydrate (MCPM), and hydroxyapatite (HA) with the chitosan-gelatin-platelet gel (CGP) on the healing of experimentally induced critical size radial bone defects in rats after 8 weeks of injury. Eighty bilateral bone defects were created in the radial bones of 40 adult male Sprague-Dawley rats...
July 31, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28757692/orbital-implant-exposure-following-enucleation-or-evisceration
#20
Huda Abdullah Al-Farsi, Buthaina Issa Sabt, Abdullah Said Al-Mujaini
PURPOSE: To study the exposure rate of orbital implant postenucleation or evisceration procedures in two tertiary hospitals in Oman. DESIGN: A retrospective, descriptive, cross-section study. MATERIALS AND METHODS: Patients' records were reviewed for patients' demographics, surgical indications, implant types, follow-up and any reported complications after surgeries. Patients with a minimum of 1 year follow-up period were selected. All patients who underwent enucleation or evisceration with primary orbital implant were included in the study...
May 2017: Oman Journal of Ophthalmology
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