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https://www.readbyqxmd.com/read/28426904/in-vitro-study-of-the-proliferation-and-growth-of-human-fetal-osteoblasts-on-mg-and-si-co-substituted-tricalcium-phosphate-ceramics
#1
Juan Parra, Ismael H García Páez, Antonio H De Aza, Carmen Baudin, M Rocío Martín, Pilar Pena
The objective of this work was to study the feasibility of the solid state sintering, a conventional ceramic processing method, to obtain Mg and Si co-substituted tricalcium phosphate bioceramics and composites containing diopside. A series of new Ca3 (PO4 )2 based ceramics has been prepared from attrition milled mixtures of synthetic Ca3 (PO4 )2 and CaMg(SiO3 )2 powders, isostatically pressed and sintered at 1250-1300°C. Materials containing 0, 1 and 5 wt.% of CaMg(SiO3 )2 were constituted by β + α - Ca3 (PO4 )2 solid solutions while the material containing 60 wt...
April 20, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28425470/graphene-oxide-as-an-interface-phase-between-polyetheretherketone-and-hydroxyapatite-for-tissue-engineering-scaffolds
#2
Shuping Peng, Pei Feng, Ping Wu, Wei Huang, Youwen Yang, Wang Guo, Chengde Gao, Cijun Shuai
The poor bonding strength between biopolymer and bioceramic has remained an unsolved issue. In this study, graphene oxide (GO) was introduced as an interface phase to improve the interfacial bonding between polyetheretherketone (PEEK) and hydroxyapatite (HAP) for tissue engineering scaffolds. On the one hand, the conjugated structure of GO could form strong π-π stacking interaction with the benzene rings in PEEK. On the other hand, GO with a negatively charge resulting from oxygen functional groups could adsorb the positively charged calcium atoms (C sites) of HAP...
April 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28415548/in-vitro-evaluation-of-ag-containing-calcium-phosphates-effectiveness-of-ag-incorporated-%C3%AE-tricalcium-phosphate
#3
Ozkan Gokcekaya, Kyosuke Ueda, Kouetsu Ogasawara, Hiroyasu Kanetaka, Takayuki Narushima
Development of bioceramics with antibacterial activity and without cytotoxicity would be beneficial for preventing infection associated with implants. This study aimed to capitalize on the antibacterial properties of silver (Ag) incorporated in or coexisting in metallic form with calcium phosphates (CaPs). The in vitro dissolution behavior, antibacterial activity, and cytotoxicity of Ag-containing CaPs with different phase fractions of hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) were evaluated...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28415532/preparation-of-micro-porous-bioceramic-containing-silicon-substituted-hydroxyapatite-and-beta-tricalcium-phosphate
#4
Lih-Jyh Fuh, Ya-Jing Huang, Wen-Cheng Chen, Dan-Jae Lin
Dimensional instability caused by sintering shrinkage is an inevitable drawback for conventional processing of hydroxyapatite (HA). A new preparation method for biphasic calcium phosphates was developed to increase micro pores and biodegradation without significant dimensional change. Powder pressed HA discs, under 100MPa, were immersed in a colloidal mixture of tetraethoxysilane (TEOS) and ammonium hydroxide for 10min, followed by drying, and then were sintered at 900°C, 1050°C, and 1200°C, respectively...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28406922/3d-fabrication-and-characterization-of-phosphoric-acid-scaffold-with-a-ha-%C3%AE-tcp-weight-ratio-of-60-40-for-bone-tissue-engineering-applications
#5
Yanen Wang, Kai Wang, Xinpei Li, Qinghua Wei, Weihong Chai, Shuzhi Wang, Yu Che, Tingli Lu, Bo Zhang
A key requirement for three-dimensional printing (3-DP) at room temperature of medical implants depends on the availability of printable and biocompatible binder-powder systems. Different concentration polyvinyl alcohol (PVA) and phosphoric acid solutions were chosen as the binders to make the artificial stent biocompatible with sufficient compressive strength. In order to achieve an optimum balance between the bioceramic powder and binder solution, the biocompatibility and mechanical properties of these artificial stent samples were tested using two kinds of binder solutions...
2017: PloS One
https://www.readbyqxmd.com/read/28386809/computer-simulations-on-the-mechanical-behaviors-of-biphasic-calcium-phosphates
#6
Xingtao Ma, Li Zhang, Hong Wu, Xingdong Zhang, Mingli Yang
Biphasic calcium phosphate (BCP) bioceramics, the mixture of hydroxyapatite (HA) and beta- tricalcium phosphate (β-TCP), are widely used as bone repair materials. Optimization of its composition and mixing pattern is crucial for its design and preparation. A series of BCP structures with a HA/β-TCP mass ratio of 0/100, 30/70, 50/50, 70/30, and 100/0 were constructed and studied with a simulated annealing molecular dynamics method. On the basis of equilibrated BCP structures, their elastic constants and moduli were computed and analyzed...
May 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28371150/polyester-fibers-can-be-rendered-calcium-phosphate-binding-by-surface-functionalization-with-bisphosphonate-groups
#7
Alessandro Polini, Daniela Geta Petre, Michele Iafisco, Sonia de Lacerda Schickert, Anna Tampieri, Jeroen van den Beucken, Sander C G Leeuwenburgh
Fibers are often used as structural elements to improve the mechanical properties of materials such as brittle ceramic matrices by facilitating the dissipation of energy. However, this energy dissipation is mainly controlled by the interface between the two components, and a poorly designed fiber-matrix interface strongly reduces the efficacy of fiber reinforcement. Here, we present a versatile approach to control the affinity of biocompatible fibers to calcium-containing matrices in order to maximize the efficacy of reinforcement of calcium phosphates based bioceramics by means of polymeric fibers...
March 28, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28361794/fabrication-of-%C3%AE-tricalcium-phosphate-composite-ceramic-sphere-based-scaffolds-with-hierarchical-pore-structure-for-bone-regeneration
#8
Fupo He, Guowen Qian, Weiwei Ren, Jiyan Li, Peirong Fan, Haishan Shi, Xuetao Shi, Xin Deng, Shanghua Wu, Jiandong Ye
Polymer sphere-based scaffolds, which are prepared by bonding the adjacent spheres via sintering the randomly packed spheres, feature uniform pore structure, full three-dimensional (3D) interconnection, and considerable mechanical strength. However, bioceramic sphere-based scaffolds fabricated by this method have never been reported. Due to high melting temperature of bioceramic, only limited diffusion rate can be achieved when sintering the bioceramic spheres, which is far from enough to form robust bonding between spheres...
March 31, 2017: Biofabrication
https://www.readbyqxmd.com/read/28348275/strontium-doped-calcium-silicate-bioceramic-with-enhanced-in-vitro-osteogenic-properties
#9
Young Jung No, Seyed-Iman Roohani-Esfahani, Zufu Lu, Jeffrey Shi, Hala Zreiqat
Gehlenite (GLN, Ca2SiAl2O7) is a bioceramic that has been recently shown to possess excellent mechanical strength and in vitro osteogenic properties for bone regeneration. Substitutional incorporation of strontium in place of calcium is an effective way to further enhance biological properties of calcium-based bioceramics and glasses. However, such strategy has the potential to affect other important physicochemical parameters such as strength and degradation due to differences in the ionic radius of strontium and calcium...
March 28, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28337435/commentary-bioceramics-and-scaffolds-a-winning-combination-for-tissue-engineering
#10
COMMENT
Eric Denes, Guislaine Barrière, Evelyne Poli, Guillaume Lévêque
No abstract text is available yet for this article.
2017: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/28327664/bioactive-silicon-nitride-a-new-therapeutic-material-for-osteoarthropathy
#11
Giuseppe Pezzotti, Elia Marin, Tetsuya Adachi, Alfredo Rondinella, Francesco Boschetto, Wenliang Zhu, Nobuhiko Sugano, Ryan M Bock, Bryan McEntire, Sonny B Bal
While the reciprocity between bioceramics and living cells is complex, it is principally governed by the implant's surface chemistry. Consequently, a deeper understanding of the chemical interactions of bioceramics with living tissue could ultimately lead to new therapeutic strategies. However, the physical and chemical principles that govern these interactions remain unclear. The intricacies of this biological synergy are explored within this paper by examining the peculiar surface chemistry of a relatively new bioceramic, silicon nitride (Si3N4)...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28321028/durability-of-alkaline-agents-bactericidal-efficacies-in-litter-under-field-conditions
#12
Hakimullah Hakim, Chiharu Toyofuku, Mari Ota, Mayuko Suzuki, Miyuki Komura, Masashi Yamada, Md Shahin Alam, Natthanan Sangsriratanakul, Dany Shoham, Kazuaki Takehara
Alkaline agents are well-known for their disinfection capacities against pathogens even at the presence of organic materials, but the durability of their bactericidal efficacies under field conditions is unknown. Therefore, within the present study, two alkaline agents, namely bioceramic (BCX) derived from chicken feces and food additive grade Ca(OH)2 (FdCa(OH)2) derived from natural lime stone, were evaluated for the persistence of their bactericidal efficacies in litter, under simulated field conditions. BCX powder mixed at 50% concentration in litter or FdCa(OH)2 powder at 20% concentration in litter lost their bactericidal efficacies at 3 days post exposure of chicks, and thereafter, both mentioned alkaline agents could not inactivate bacteria down to the acceptable level (≥3 log10 CFU/ml reduction)...
March 19, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28287077/bone-regeneration-in-3d-printing-bioactive-ceramic-scaffolds-with-improved-tissue-material-interface-pore-architecture-in-thin-wall-bone-defect
#13
Huifeng Shao, Xiurong Ke, An Liu, Miao Sun, Yong He, Xianyan Yang, Jianzhong Fu, Yanming Liu, Lei Zhang, Guojing Yang, Sanzhong Xu, Zhongru Gou
Three-dimensional (3D) printing bioactive ceramics have demonstrated alternative approaches to bone tissue repair, but an optimized materials system for improving the recruitment of host osteogenic cells into the bone defect and enhancing targeted repair of the thin-wall craniomaxillofacial defects remains elusive. Herein we systematically evaluated the role of side-wall pore architecture in the direct-ink-writing bioceramic scaffolds on mechanical properties and osteogenic capacity in rabbit calvarial defects...
April 12, 2017: Biofabrication
https://www.readbyqxmd.com/read/28269744/osteoblast-like-cell-responses-to-ion-products-released-from-magnesium-and-silicate-containing-calcium-carbonates
#14
Shinya Yamada, Yoshio Ota, Akiko Obata, Toshihiro Kasuga
BACKGROUND: Inorganic ions released from bioceramics and bioactive glasses have been reported to influence osteogenic cell functions. Cell responses depend on types of the ions provided, for example, silicate ion has been found to up-regulate their proliferation, differentiation and mineralization. OBJECTIVE: Mouse osteoblast-like cells (MC3T3-E1) were cultured in media containing silicate and calcium ions with/without magnesium ion to evaluate their combined effects on the cell's functions...
2017: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/28258809/solid-state-nmr-and-computational-insights-into-the-crystal-structure-of-silicocarnotite-based-bioceramic-materials-synthesized-mechanochemically
#15
A S Andreev, N V Bulina, M V Chaikina, I Yu Prosanov, V V Terskikh, O B Lapina
In this work, we report the results of a detailed structural study of a promising bioceramic material silicocarnotite Ca5(PO4)2SiO4 (SC) synthesized from mechanochemically treated nanosized silicon-substituted hydroxyapatite by annealing at 1000°C. This novel synthetic approach represents an attractive and efficient route towards large-scale manufacturing of the silicocarnotite-based bioceramics. A combination of solid-state nuclear magnetic resonance (NMR), powder X-ray crystallography and density function theory (DFT) calculations has been implemented to characterize the phase composition of the prepared composite materials and to gain insight into the crystal structure of silicocarnotite...
February 22, 2017: Solid State Nuclear Magnetic Resonance
https://www.readbyqxmd.com/read/28240268/fabrication-and-in-vitro-biological-properties-of-piezoelectric-bioceramics-for-bone-regeneration
#16
Yufei Tang, Cong Wu, Zixiang Wu, Long Hu, Wei Zhang, Kang Zhao
The piezoelectric effect of biological piezoelectric materials promotes bone growth. However, the material should be subjected to stress before it can produce an electric charge that promotes bone repair and reconstruction conducive to fracture healing. A novel method for in vitro experimentation of biological piezoelectric materials with physiological load is presented. A dynamic loading device that can simulate the force of human motion and provide periodic load to piezoelectric materials when co-cultured with cells was designed to obtain a realistic expression of piezoelectric effect on bone repair...
February 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28210204/physicochemical-properties-of-epoxy-resin-based-and-bioceramic-based-root-canal-sealers
#17
Ju Kyung Lee, Sang Won Kwak, Jung-Hong Ha, WooCheol Lee, Hyeon-Cheol Kim
Three bioceramic sealers (EndoSequence BC sealer, EndoSeal MTA, and MTA Fillapex) and three epoxy resin-based sealers (AH-Plus, AD Seal, and Radic-Sealer) were tested to evaluate the physicochemical properties: flow, final setting time, radiopacity, dimensional stability, and pH change. The one-way ANOVA and Tukey's post hoc test were used to analyze the data (P = 0.05). The MTA Fillapex sealer had a highest flow and the BC Sealer presented a flow significantly lower than the others (P < 0.05). The BC Sealer and MTA Fillapex samples were not set in humid incubator condition even after one month...
2017: Bioinorganic Chemistry and Applications
https://www.readbyqxmd.com/read/28199184/biphasic-organo-bioceramic-fibrous-composite-as-a-biomimetic-extracellular-matrix-for-bone-tissue-regeneration
#18
Sanjay Kumar, James A Stokes Iii, Derrick Dean, Christian Rogers, Elijah Nyairo, Vinoy Thomas, Manoj K Mishra
In bone tissue engineering, the organo-ceramic composite, electrospun polycaprolactone/hydroxyapatite (PCL/HA) scaffold has the potential to support cell proliferation, migration, differentiation, and homeostasis. Here, we report the effect of PCL/HA scaffold in tissue regeneration using human mesenchymal stem cells (hMSCs). We characterized the scaffold by fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), scanning electron microscope (SEM) and assessed its biocompatibility...
March 1, 2017: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/28194360/retreatability-of-two-endodontic-sealers-endosequence-bc-sealer-and-ah-plus-a-micro-computed-tomographic-comparison
#19
Enrique Oltra, Timothy C Cox, Matthew R LaCourse, James D Johnson, Avina Paranjpe
OBJECTIVES: Recently, bioceramic sealers like EndoSequence BC Sealer (BC Sealer) have been introduced and are being used in endodontic practice. However, this sealer has limited research related to its retreatability. Hence, the aim of this study was to evaluate the retreatability of two sealers, BC Sealer as compared with AH Plus using micro-computed tomographic (micro-CT) analysis. MATERIALS AND METHODS: Fifty-six extracted human maxillary incisors were instrumented and randomly divided into 4 groups of 14 teeth: 1A, gutta-percha, AH Plus retreated with chloroform; 1B, gutta-percha, AH Plus retreated without chloroform; 2A, gutta-percha, EndoSequence BC Sealer retreated with chloroform; 2B, gutta-percha, EndoSequence BC Sealer retreated without chloroform...
February 2017: Restorative Dentistry & Endodontics
https://www.readbyqxmd.com/read/28183671/effect-of-phosphorus-precursors-on-the-structure-of-bioactive-calcium-phosphate-silicate-systems
#20
Katalin Sinkó, Anikó Meiszterics, János Rohonczy, Balázs Kobzi, Shiro Kubuki
The main aim of this work was to synthesize calcium phosphate silicate bioceramics by a low energy-consuming sol-gel method applying various phosphorous precursors (triethyl phosphate, phosphoric acid, and ammonium hydrogen phosphate). The investigations concentrated on the influence of phosphorous initial compounds on the bond and crystalline structures and the material quality. The application of the alkoxide and inorganic P-precursors results in considerably different textures. The inorganic PO4-containing precursors lead to sol formations...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
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