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https://www.readbyqxmd.com/read/29123140/effects-of-atomic-level-nano-structured-hydroxyapatite-on-adsorption-of-bone-morphogenetic-protein-7-and-its-derived-peptide-by-computer-simulation
#1
Qun Wang, Menghao Wang, Xiong Lu, Kefeng Wang, Liming Fang, Fuzeng Ren, Guoming Lu
Hydroxyapatite (HA) is the principal inorganic component of bones and teeth and has been widely used as a bone repair material because of its good biocompatibility and bioactivity. Understanding the interactions between proteins and HA is crucial for designing biomaterials for bone regeneration. In this study, we evaluated the effects of atomic-level nano-structured HA (110) surfaces on the adsorption of bone morphogenetic protein-7 (BMP-7) and its derived peptide (KQLNALSVLYFDD) using molecular dynamics and density functional theory methods...
November 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29098767/silicon-bioceramic-loaded-with-vancomycin-stimulates-bone-tissue-regeneration
#2
Angel Manchón, Mohammad H Alkhraisat, Carmen Rueda-Rodriguez, Concepción Pintado, J C Prados-Frutos, Jesus Torres, Enrique Lopez Cabarcos
Porous ceramics doped with silicon and pure β-TCP were analyzed in terms of internal microstructure, cell behavior, and the percentage of newly formed bone. Additionally the materials were tested to determine which of the two had better properties to load and release vancomycin hydrochloride. Internal pore distribution and porosity were determined through high pressure mercury porosimetry and the specific surface area was measured by the Brunauer Emmet-Teller method. The proliferation and viability of the human osteoblast-like cell line MG-63 was studied to validate both materials...
November 3, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29080076/evaluation-of-the-interface-between-gutta-percha-and-two-types-of-sealers-using-scanning-electron-microscopy-sem
#3
Mohamed Eltair, Vinay Pitchika, Reinhard Hickel, Jan Kühnisch, Christian Diegritz
OBJECTIVES: The aim of the present study was to evaluate the adaptation of a calcium silicate bioceramic (BC) sealer with either BC or conventional gutta-percha compared with that of AH Plus sealer in different root canal sections. MATERIALS AND METHODS: Seventy-two extracted mandibular premolars were divided randomly into six groups. After standardised chemomechanical preparation, four groups were obturated with the BC sealer and BC gutta-percha or conventional gutta-percha, and the other two groups were obturated with AH Plus sealer and conventional gutta-percha either in lateral compaction or in a single cone technique...
October 27, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29066420/cu-doping-of-calcium-phosphate-bioceramics-from-mechanism-to-the-control-of-cytotoxicity
#4
Sandrine Gomes, Charlotte Vichery, Stéphane Descamps, Hervé Martinez, Amandeep Kaur, Aurélie Jacobs, Jean-Marie Nedelec, Guillaume Renaudin
In this study, the Cu-doping mechanism of Biphasic Calcium Phosphate (BCP) was thoroughly investigated, as was its ionic release behavior, in order to elucidate cytotoxicity features of these bioceramics. BCP are composed of hydroxyapatite (Ca10(PO4)6(OH)2) and β-TCP (Ca3(PO4)2). The two phases present two different doping mechanisms. Incorporation into the β-TCP structure is achieved at around 700 °C thanks to a substitution mechanism leading to the Cu-doped Ca3-xCux(PO4)2 compound. Incorporation into the HAp structure is achieved thanks to an interstitial mechanism that is limited to a Cu-poor HAp phase for temperatures below 1100 °C (Ca10Cux(PO4)6(OH)2-2xO2x with x < 0...
October 21, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29061357/saving-natural-teeth-intentional-replantation-protocol-and-case-series
#5
Derek Grzanich, Gabriella Rizzo, Renato Menezes Silva
INTRODUCTION: Intentional replantation is a reliable and predictable treatment for cases in which nonsurgical endodontic retreatment failed or is impractical and endodontic surgery is hampered because of anatomic limitations. METHODS AND RESULTS: This article presents a protocol for intentional replantation illustrated with some interesting cases. The cases presented here are from patients (average age, 61 years) with no contributing medical history. The cases are molars with previous failed endodontic treatment/retreatment and diagnosed with apical periodontitis...
October 20, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/29061354/odontogenic-potential-of-parathyroid-hormone-related-protein-107-111-alone-or%C3%A2-in%C3%A2-combination-with-mineral-trioxide-aggregate%C3%A2-in-human-dental-pulp-cells
#6
Jeong-Won Han, Bin-Na Lee, Se-Min Kim, Jeong-Tae Koh, Kyung-San Min, Yun-Chan Hwang
INTRODUCTION: Parathyroid hormone-related protein plays an important role in bone remodeling. Its N-terminal domain parathyroid hormone-related protein (107-111) is called osteostatin (OST). OST has demonstrated osteogenic potential when combined with biomaterials such as hydroxyapatite or bioceramics. However, the odontogenic potential of OST has not yet been reported. Therefore, the aim of this study was to determine whether OST has an odontogenic effect or a synergistic effect with mineral trioxide aggregate (MTA) in human dental pulp cells (hDPCs) and to examine the underlying signaling mechanisms involved in OST-mediated odontogenic differentiation...
October 20, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/29042721/clinical-and-radiographic-evaluation-of-citric-acid-based-nano-hydroxyapatite-composite-graft-in-the-regeneration-of-intrabony-defects-a-randomized-controlled-trial
#7
Chaurasia Priya Dayashankar, P C Deepika, Basavarajaiah Siddaramaiah
BACKGROUND: Conventional periodontal therapy with various bone grafts has limited scope and the results are not predictable. To improve their utility, the hybridization of bioceramics and biodegradable polymers has been widely adopted to reform the mechanical properties of bone grafts. One such biodegradable polymer is POC (Poly 1,8 octanediol). Secondly, citric acid is considered as the key material in bone mineralization, which is related to the overall stability, strength and fracture resistance of bone...
July 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29022137/effect-of-different-endodontic-sealers-and-time-of-cementation-on-push-out-bond-strength-of-fiber-posts
#8
Danielle Araújo Vilas-Boas, Renata Grazziotin-Soares, Diego Machado Ardenghi, José Bauer, Patrícia Oliveira de Souza, George Táccio de Miranda Candeiro, Etevaldo Matos Maia-Filho, Ceci Nunes Carvalho
OBJECTIVES: This study aims to evaluate the effect of different endodontic sealers (epoxy resin, eugenol, and bioceramic/calcium silicate-based) and the time of cementation (immediately or 7 days after canal obturation) on the bond strength of a fiberglass post cemented with RelyX™ ARC. MATERIAL AND METHODS: Eighty-four premolars were instrumented and divided into groups (n = 12) according to the sealer and the time of post cementation: Endofill (EN), Endosequence BC Sealer (BC), and AH Plus (AH) had immediately fiber post cementation; EN7, BC7, and AH7 had post cementation after 7 days; and control group (C) had fiber post cementation without endodontic sealer...
October 11, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29020507/custom-repair-of-mandibular-bone-defects-with-3d-printed-bioceramic-scaffolds
#9
H Shao, M Sun, F Zhang, A Liu, Y He, J Fu, X Yang, H Wang, Z Gou
Implanting artificial biomaterial implants into alveolar bone defects with individual shape and appropriate mechanical strength is still a challenge. In this study, bioceramic scaffolds, which can precisely match the mandibular defects in macro and micro, were manufactured by the 3-dimensional (3D) printing technique according to the computed tomography (CT) image. To evaluate the stimulatory effect of the material substrate on bone tissue regeneration in situ in a rabbit mandibular alveolar bone defect model, implants made with the newly developed, mechanically strong ~10% Mg-substituted wollastonite (Ca90%Mg10%SiO3; CSi-Mg10) were fabricated, implanted into the bone defects, and compared with implants made with the typical Ca-phosphate and Ca-silicate porous bioceramics, such as β-tricalcium phosphate (TCP), wollastonite (CaSiO3; CSi), and bredigite (Bred)...
October 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28993220/silk-fibroin-hydroxyapatite-composites-for-bone-tissue-engineering
#10
REVIEW
Mehdi Farokhi, Fatemeh Mottaghitalab, Saeed Samani, Mohammad Ali Shokrgozar, Subhas C Kundu, Rui L Reis, Yousef Fattahi, David L Kaplan
Silk fibroin (SF) is a natural fibrous polymer with strong potential for many biomedical applications. SF has attracted interest in the field of bone tissue engineering due to its extraordinary characteristics in terms of elasticity, flexibility, biocompatibility and biodegradability. However, low osteogenic capacity has limited applications for SF in the orthopedic arena unless suitably functionalized. Hydroxyapatite (HAp) is a well-established bioceramic with biocompatibility and appropriate for constructing orthopedic and dental substitutes...
October 6, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/28987039/reduction-in-pain-after-use-of-bioceramic-undershirt-for-patients-with-fibromyalgia
#11
María Aparecida Santos E Campos, Felipe García Pinillos, Pedro Ángel Latorre Román
Context • The treatment of pain in fibromyalgia (FM) has centered on pharmacotherapy and nonpharmacological treatment. The nondrug treatments for FM include the effects of far infrared radiation (FIR). Currently, FIR-emitting heat lamps and garments made of filaments (fibers) impregnated with FIR-emitting nanoparticles are being used to deliver thermal radiation effects. Objective • The study intended to determine the benefits of a fabric coated with bioceramics for reducing pain in women with FM. Design • The research team designed a randomized, controlled pilot study...
September 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28986683/hydroxyapatite-chitosan-biocomposites-synthesized-in-the-simulated-body-fluid-and-their-drug-loading-studies
#12
Tugba Basargan, Nalan Erdol-Aydin, Gulhayat Nasun-Saygili
Hydroxyapatite (HAp) is a bioceramic applied in the biomedical areas, such as matrices for drug release control. Chitosan (CTS), a natural polymer, is another material has been widely investigated for its potential use in the drug delivery systems. In this study, the composites of HAp-CTS are produced in order to investigate their drug loading and release studies. First of all, HAp-CTS composites are produced in the presence of simulated body fluid (SBF). Analysis confirmed the structure of HAp-CTS composites...
October 6, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28967188/bioactive-nano-fibrous-scaffold-for-vascularized-craniofacial-bone-regeneration
#13
Rahul Damodaran Prabha, David Christian Evar Kraft, Linda Harkness, Birte Melsen, Harikrishna Varma, Prabha D Nair, Jorgen Kjems, Mousthapha Kassem
There has been a growing demand for bone grafts for correction of bone defects in complicated fractures or tumors in the craniofacial region. Soft flexible membrane like material that could be inserted into defect by less invasive approaches; promote osteoconductivity and act as a barrier to soft tissue in growth while promoting bone formation is an attractive option for this region. Electrospinning has recently emerged as one of the most promising techniques for fabrication of extracellular matrix (ECM) like nano-fibrous scaffolds that can serve as a template for bone formation...
October 2, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28954399/biodegradable-materials-and-metallic-implants-a-review
#14
REVIEW
Mythili Prakasam, Janis Locs, Kristine Salma-Ancane, Dagnija Loca, Alain Largeteau, Liga Berzina-Cimdina
Recent progress made in biomaterials and their clinical applications is well known. In the last five decades, great advances have been made in the field of biomaterials, including ceramics, glasses, polymers, composites, glass-ceramics and metal alloys. A variety of bioimplants are currently used in either one of the aforesaid forms. Some of these materials are designed to degrade or to be resorbed inside the body rather than removing the implant after its function is served. Many properties such as mechanical properties, non-toxicity, surface modification, degradation rate, biocompatibility, and corrosion rate and scaffold design are taken into consideration...
September 26, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28952559/lysine-grafted-mcm-41-silica-as-an-antibacterial-biomaterial
#15
María F Villegas, Lorena Garcia-Uriostegui, Ofelia Rodríguez, Isabel Izquierdo-Barba, Antonio J Salinas, Guillermo Toriz, María Vallet-Regí, Ezequiel Delgado
This paper proposes a facile strategy for the zwitterionization of bioceramics that is based on the direct incorporation of l-lysine amino acid via the ε-amino group onto mesoporous MCM-41 materials. Fourier transform infrared (FTIR) studies of lysine-grafted MCM-41 (MCM-LYS) simultaneously showed bands at 3080 and 1540 cm(-1) and bands at 1625 and 1415 cm(-1) corresponding to -NH(3+)/COO(-) pairs, which demonstrate the incorporation of the amino acid on the material surface keeping its zwitterionic character...
September 26, 2017: Bioengineering
https://www.readbyqxmd.com/read/28942129/bone-regeneration-with-micro-nano-hybrid-structured-biphasic-calcium-phosphate-bioceramics-at-segmental-bone-defect-and-the-induced-immunoregulation-of-mscs
#16
Yu Zhu, Kun Zhang, Rui Zhao, Xingjiang Ye, Xuening Chen, Zhanwen Xiao, Xiao Yang, Xiangdong Zhu, Kai Zhang, Yujiang Fan, Xingdong Zhang
Adequate bone regeneration has been difficult to achieve at segmental bone defects caused by disease. The surface structure and phase composition of calcium phosphate bioceramic are crucial for its bioactivity and osteoinductivity. In the present study, biphasic calcium phosphate (BCP) bioceramics composed of micro-whiskers and nanoparticles hybrid-structured surface (hBCP) were fabricated via a hydrothermal reaction. The in vivo long bone defect model of beagle dogs implanted with hBCP bioceramics achieved a higher quality regenerated bone as compared to the traditional smooth-surface BCP control group...
September 18, 2017: Biomaterials
https://www.readbyqxmd.com/read/28917940/natural-and-synthetic-polymers-bioceramics-bioactive-compounds-mediated-cell-signaling-in-bone-tissue-engineering
#17
REVIEW
S Harsha Rao, B Harini, R Pranav Kumar Shadamarshan, K Balagangadharan, N Selvamurugan
Bone is a highly integrative and dynamic tissue of the human body. It is continually remodeled by bone cells such as osteoblasts, osteoclasts. When a fraction of a bone is damaged or deformed, stem cells and bone cells under the influence of several signaling pathways regulate bone regeneration at the particular locale. Effective therapies for bone defects can be met via bone tissue engineering which employs drug delivery systems with biomaterials to enhance cellular functions by acting on signaling pathways such as Wnt, BMP, TGF-β, and Notch...
September 13, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28882956/osteochondral-repair-using-porous-three-dimensional-nanocomposite-scaffolds-in-a-rabbit-model
#18
Beata Żylińska, Ewa Stodolak-Zych, Aleksandra Sobczyńska-Rak, Tomasz Szponder, Piotr Silmanowicz, Mirosław Łańcut, Łukasz Jarosz, Paweł Różański, Izabela Polkowska
AIM: To evaluate the utility of a novel nanocomposite biomaterial consisting of poly-L/D-lactide, and hydroxyapatite bioceramics, enriched with sodium alginate in articular cartilage defect treatment. MATERIALS AND METHODS: The biomaterial was prepared using the method of solvent casting and particle leaching. The study was conducted on 20 New Zealand White rabbits. Experimental osteochondral defects were created in the femoral trochlear grooves and filled with biomaterials...
September 2017: In Vivo
https://www.readbyqxmd.com/read/28877288/effect-of-rewetting-solutions-on-micropush-out-dentin-bond-strength-of-new-bioceramic-endodontic-material
#19
Giovana Cunha Gritti, Salma Ivanna Araújo Cavalcante, Etevaldo Matos Maia-Filho, José Bauer, Matheus Coêlho Bandéca, Giulio Gavini, Ceci Nunes Carvalho
To evaluate the influence of rewetting solutions on bond strength to root dentin of conventional gutta-percha (GP) or niobium phosphate glass-based gutta-percha (GNb) associated with a bioceramic sealer. The root canals of 80 human mandibular premolars were prepared using nickel-titanium instruments and irrigation with sodium hypochlorite and EDTA. The teeth were randomly divided into four groups according to the gutta-percha used: GNb or GP associated with EndoSequence BC Sealer (BC) and the solution for rewetting dentin before filling (distilled water; phosphate buffer saline solution - PBS; simulated body fluid - SBF; or no solution)...
August 31, 2017: Brazilian Oral Research
https://www.readbyqxmd.com/read/28865173/the-extracts-of-bredigite-bioceramics-enhanced-the-pluripotency-of-human-dental-pulp-cells
#20
Lihong Chen, Lu Liu, Chengtie Wu, Ruiqi Yang, Jiang Chang, Xi Wei
Biomaterials have a profound effect on tissue engineering and regenerative medicine, but few studies have reported the role of extracts from bioceramics in the regulation of stem cell pluripotency. The present study investigated the effects of bioceramics extracts, including silicate bredigite (Ca7 MgSi4 O16 ) and conventional β-tricalcium phosphate (β-TCP), on the pluripotency and the multilineage differentiation potential of human dental pulp cells (hDPCs). Basic fibroblast growth factor (bFGF), which is a known regulator of hDPCs pluripotency, was used as a reference...
December 2017: Journal of Biomedical Materials Research. Part A
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