Zixuan Su, Chuan Guo, Xingyu Gui, Lina Wu, Boqing Zhang, Yuxiang Qin, Zhen Tan, Changchun Zhou, Wei Wei, Yujiang Fan, Xingdong Zhang
Numerous studies have shown that there are multiple neural activities involved in the process of bone resorption and bone regeneration, and promoting osteogenesis by promoting neural network reconstruction is an effective strategy for repairing critical size bone defects. However, traumatic bone defects often cause activation of the sympathetic nervous system (SNS) in the damaged area, releasing excess catecholamines (CAs), resulting in a decrease in the rate of bone formation. Herein, a 3D-printed scaffold loaded with propranolol (PRN) is proposed to reduce CA concentrations in bone defect areas and promote bone regeneration through drug release...
April 10, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine