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Shi Yun Tong, Zuyong Wang, Poon Nian Lim, Wilson Wang, Eng San Thian
Regeneration of injuries at tendon-to-bone interface (TBI) remains a challenging issue due to the complex tissue composition involving both soft tendon tissues and relatively hard bone tissues. Tissue engineering using polymeric/ceramic composites has been of great interest to generate scaffolds for tissue's healing at TBI. Herein, we presented a novel method to blend polymers and bioceramics for tendon tissue engineering application. A homogeneous composite comprising of nanohydroxyapatite (nHA) particles in poly(ε-caprolactone) (PCL) matrix was obtained using a combination of solvent and mechanical blending process...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
Shoujie Liu, Hejun Li, Yangyang Su, Qian Guo, Leilei Zhang
Carbon nanotubes (CNTs) possess excellent mechanical properties for their role playing in reinforcement as imparting strength to brittle hydroxyapatite (HA) bioceramic coating. However, there are few reports relating to the in-situ grown carbon nanotubes reinforced hydroxyapatite (CNTs-HA) coating. Here we demonstrate the potential application in reinforcing biomaterials by an attempt to use in-situ grown of CNTs strengthen HA coating, using a combined method composited of injection chemical vapor deposition (ICVD) and pulsed electrodeposition...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
Ali Farzin, Mohammadhossein Fathi, Rahmatollah Emadi
Hyperthermia and local drug delivery have been proposed as potential therapeutic approaches for killing cancer cells. The development of bioactive materials such as Hardystonite (HT) with magnetic and drug delivery properties can potentially meet this target. This new class of magnetic bioceramic can replace the widely used magnetic iron oxide nanoparticles, whose long-term biocompatibility is not clear. Magnetic HT can be potentially employed to develop new ceramic scaffolds for bone surgery and anticancer therapies...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
Hongshi Ma, Jian Luo, Zhe Sun, Lunguo Xia, Mengchao Shi, Mingyao Liu, Jiang Chang, Chengtie Wu
Primary bone cancer brings patients great sufferings. To deal with the bone defects resulted from cancer surgery, biomaterials with good bone-forming ability are necessary to repair bone defects. Meanwhile, in order to prevent possible tumor recurrence, it is essential that the remaining tumor cells around bone defects are completely killed. However, there are few biomaterials with the ability of both cancer therapy and bone regeneration until now. Here, we fabricated a 3D-printed bioceramic scaffold with a uniformly self-assembled Ca-P/polydopamine nanolayer surface...
December 2016: Biomaterials
Sarah Bukhari, Meetu R Kohli, Frank Setzer, Bekir Karabucak
INTRODUCTION: The purpose of this retrospective case series was to investigate the outcome of the revascularization procedure in necrotic immature teeth. METHODS: The residents and faculty members at the University of Pennsylvania endodontic department were invited to submit consecutive revascularization cases treated by them, irrespective of the outcome, during the time period of 2009 to 2012. Twenty-eight of 35 submitted necrotic immature teeth met the inclusion criteria...
October 7, 2016: Journal of Endodontics
Parisa Sanaei-Rad, Tahereh-Sadat Jafarzadeh Kashi, Ehsan Seyedjafari, Masoud Soleimani
A combination of polymeric materials and bioceramics has recently received a great deal of attention for bone tissue engineering applications. In the present study, hybrid nanofibrous scaffolds were fabricated from PLGA and gelatin via electrospinning and then were coated with hydroxyapatite (HA). They were then characterized and used in stem cell culture studies for the evaluation of their biological behavior and osteogenic differentiation in vitro. This study showed that all PLGA, hybrid PLGA/gelatin and HA-PLGA/gelatin scaffolds were composed of ultrafine fibers with smooth morphology and interconnected pores...
October 5, 2016: Biologicals: Journal of the International Association of Biological Standardization
Travis K Mann-Gow, Benjamin J King, Ahmed El-Ghannam, Christine Knabe-Ducheyne, Masatoshi Kida, Ole M Dall, Jan Krhut, Peter Zvara
Objectives. To test the physical properties and host response to the bioceramic particles, silica-calcium phosphate (SCPC10) and Cristobalite, in a rat animal model and compare their biocompatibility to the current clinically utilized urethral bulking materials. Material and Methods. The novel bulking materials, SCPC10 and Cristobalite, were suspended in hyaluronic acid sodium salt and injected into the mid urethra of a rat. Additional animals were injected with bulking materials currently in clinical use. Physiological response was assessed using voiding trials, and host tissue response was evaluated using hard tissue histology and immunohistochemical analysis...
2016: Advances in Urology
Anja Baraba, Sonja Pezelj-Ribaric, Marija Roguljić, Ivana Miletic
OBJECTIVE: The aim of this study was to investigate the cytotoxicity of two different bioactive root canal sealers: one based on mineral trioxide aggregate, MTA Fillapex (Angelus, Solucoes Odontologicas, Londrina, PR, Brazil), and the other based on bioceramics, Endosequence BC Sealer (Brasseler, Savannah, Georgia, USA), in culture of mouse L929 fibroblasts. MATERIALS AND METHODS: Mouse fibroblasts (L929), obtained from subcutaneous connective tissue of mouse line C3Hf, were cultivated in plastic culture flasks in an incubator at 37şC, with 5% CO2 and 90% humidity...
March 2016: Acta Stomatologica Croatica
Deniz Torun, Zeynep Ö Torun, Kadriye Demirkaya, Meral Sarper, Mualla P Elçi, Ferit Avcu
We evaluated the gene expression profiles of human dental pulp cells exposed to iRoot BP using microarray after 24 and 72 h. The results were verified using quantitative reverse transcriptase PCR analysis. Of the 36,000 transcripts arrayed, 21 were up-regulated and 15 were down-regulated by more than two fold. The largest group of up-regulated genes included those involved in nucleobase-containing compound metabolic processes, cell communication, protein metabolic processes, developmental processes, and biological regulation...
2016: Journal of Oral Science
S Alsubait, S Al-Haidar, N Al-Sharyan
OBJECTIVE: To compare the discoloration potential of Endosequence Bioceramic Root Repair Material fast set putty (ERRMF) and ProRoot MTA (PMTA) when placed coronally in human extracted teeth over a 4-month period. METHODOLOGY: Forty-eight premolars were sectioned 2 mm below the cementoenamel junction. The pulp chambers were cleaned chemo-mechanically. The specimens were randomly assigned to three groups: PMTA, ERRMF, and no fill (control). Tooth color was measured spectrophotometrically at six time points: after material placement, after 2, 4, 8, 12, and 16 weeks...
September 17, 2016: Journal of Esthetic and Restorative Dentistry
Miguel Castilho, Jorge Rodrigues, Elke Vorndran, Uwe Gbureck, Carlos Quental, João Folgado, Paulo R Fernandes
Tibial tuberosity advancement (TTA) is a promising method for the treatment of cruciate ligament rupture in dogs that usually implies the implantation of a titanium cage as bone implant. This cage is non-biodegradable and fails in providing adequate implant-bone tissue integration. The objective of this work is to propose a new process chain for designing and manufacturing an alternative biodegradable cage that can fulfill specific patient requirements. A three-dimensional finite element model (3D FEM) of the TTA system was first created to evaluate the mechanical environment at cage domain during different stages of the dog walk...
September 2, 2016: Journal of the Mechanical Behavior of Biomedical Materials
Yanqiu Yang, Fupo He, Jiandong Ye
In this study, phosphate-based glass (PG) was used as a sintering aid for freeze-cast porous biphasic calcium phosphate (BCP) ceramic, which was sintered under a lower temperature (1000°C). The phase composition, pore structure, compressive strength, and cytocompatibility of calcium phosphate composite ceramics (PG-BCP) were evaluated. The results indicated that PG additive reacted with calcium phosphate during the sintering process, forming β-Ca2P2O7; the ions of sodium and magnesium from PG partially substituted the calcium sites of β-calcium phosphate in BCP...
December 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
Zhong Li, Brianna C Thompson, Zhili Dong, Khiam Aik Khor
Transparent bioceramics have attracted a large amount of research interest as they facilitate direct observation of biointerfacial reactions. Thus far, attempts to achieve transparent hydroxyapatite have been focused on augmenting the sintering pressure and/or extending the sintering duration. This study aims at fabricating transparent HA using a direct and fast spark plasma sintering process with appropriate starting powder and moderate sintering pressure. Three types of raw powder, namely micro-spheres, nano-rods and nano-spheres, were sintered to investigate the optical and biological properties of the compacted pellets...
December 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
Chanathip Thammakarn, Natthanan Sangsriratanakul, Yuki Ishida, Atsushi Suguro, Masashi Yamada, Chiharu Toyofuku, Katsuhiro Nakajima, Minori Kitazawa, Mari Ota, Hakimullah Hakim, Md Shahin Alam, Dany Shoham, Kazuaki Takehara
Bioceramic derived from chicken feces (BCX) is a material produced by a sintering process for the purpose of use in animal farms to control livestock infectious diseases. In the present study, BCX at pH 13 was evaluated for the durability of its virucidal activity in simulated field conditions. First it was shown that BCX had activity toward Newcastle disease virus, infectious bursal disease virus, and goose parvovirus within 3 min and toward avian influenza virus (AIV) within 1 hr. BCX was further tested by keeping it under simulated harsh environmental conditions with sunlight for several weeks as well as by repeatedly soaking it with water and drying under sunlight many times...
September 2016: Avian Diseases
An Liu, Miao Sun, Xianyan Yang, Chiyuan Ma, Yanming Liu, Xu Yang, Shigui Yan, Zhongru Gou
Some Ca-Mg-silicate ceramics have been widely investigated to be highly bioactive and biodegradable, whereas their osteogenic potential and especially biomechanical response in the early stage in vivo are scarcely demonstrated. Herein, the osteogenesis capacity and mechanical evolution of the akermanite (Ca2MgSi2O7) porous materials manufactured by ceramic ink writing three-dimensional printing technique were investigated systematically in a critical size femur defect model, in comparison with the clinically available β-tricalcium phosphate porous bioceramic...
September 1, 2016: Journal of Biomaterials Applications
Bahram Amiri, Marzieh Ghollasi, Mohsen Shahrousvand, Mehdi Kamali, Ali Salimi
Tissue engineering has attracted a great deal of interest by combining fibrous scaffolds and stem cells regarding bone regeneration applications. In the present study, polymeric fibrous polyethersulphone-polyethylene glycol (PES-PEG) was fabricated by electrospinning. It was then treated with NH3 plasma to enhance surface hydrophilicity, cell attachment, growth and differentiation potential. X-ray photoelectron spectroscopy (XPS) measurements were used to evaluate the modification of the scaffold's surface chemistry...
August 26, 2016: Differentiation; Research in Biological Diversity
Y A Fillingham, G L Cvetanovich, B D Haughom, B J Erickson, S Gitelis
PURPOSE: To review the outcome of 12 patients who underwent debridement and injection of bioceramic for unicameral bone cyst (UBC). The resorption rate of the bioceramic was estimated by both traditional and novel methods. METHODS: Records of 10 males and 2 females aged 6 to 34 years who underwent debridement and injection of bioceramic for UBC and were followed up for a mean of 41 (range, 26-57) months were reviewed. Functional outcome was assessed using the selfcompleted Musculoskeletal Tumor Society (MSTS) questionnaire...
August 2016: Journal of Orthopaedic Surgery
Swapnika Polineni, Nagesh Bolla, Pragna Mandava, Sayesh Vemuri, Madhusudana Mallela, Vijaya Madhuri Gandham
AIM: This in vitro study evaluated and compared the marginal adaptation of three newer root canal sealers to root dentin. MATERIALS AND METHODS: Thirty freshly extracted human single-rooted teeth with completely formed apices were taken. Teeth were decoronated, and root canals were instrumented. The specimens were randomly divided into three groups (n = 10) based upon the sealer used. Group 1 - teeth were obturated with epoxy resin sealer (MM-Seal). Group 2 - teeth were obturated with mineral trioxide aggregate (MTA) based sealer (MTA Fillapex), Group 3 - teeth were obturated with bioceramic sealer (EndoSequence BC sealer)...
July 2016: Journal of Conservative Dentistry: JCD
Ju-Ang Kim, Jiwon Lim, Raja Naren, Hui-Suk Yun, Eui Kyun Park
UNLABELLED: Similar to calcium phosphates, magnesium phosphate (MgP) ceramics have been shown to be biocompatible and support favorable conditions for bone cells. Micropores below 25μm (MgP25), between 25 and 53μm (MgP53), or no micropores (MgP0) were introduced into MgP scaffolds using different sizes of an NaCl template. The porosities of MgP25 and MgP53 were found to be higher than that of MgP0 because of their micro-sized pores. Both in vitro and in vivo analysis showed that MgP scaffolds with high porosity promoted rapid biodegradation...
October 15, 2016: Acta Biomaterialia
Sang-Hyuk Sohn, Sung-Am Cho
PURPOSE: Sandblasted and acid-etched (SLA) implants are widely known and used by many practitioners. A resorbable blasting media (RBM) surface is produced by blasting with bioceramic particles. We studied the correlation between the particle sizes of the media and the biomechanical force, evaluating the removal torque of hydroxyapatite-blasted implants. MATERIALS AND METHODS: Commercial SLA implants comprised the control group, and RBM surface-treated implants of the same size and design comprised the experimental group...
October 2016: Implant Dentistry
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