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https://www.readbyqxmd.com/read/29781148/improved-osteogenesis-of-boron-incorporated-calcium-silicate-coatings-via-immunomodulatory-effects
#1
Xiang Lu, Kai Li, Youtao Xie, Shengcai Qi, Qingyi Shen, Jiangming Yu, Liping Huang, Xuebin Zheng
Osteoimmunology has revealed the importance of a favorable immune response for successful biomaterial-mediated osteogenesis. Boron-incorporated calcium silicate (Ca11 Si4 B2 O22 , B-CS) coating has been reported as a potential candidate for improving osteogenesis in orthopedic applications in vitro. However, relatively little is known about its effects on the immune response and subsequent osteogenesis. In this work, the immunomodulatory properties of the B-CS coating and its specific mechanism of action were explored...
May 20, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29775436/modelling-the-degree-of-porosity-of-the-ceramic-surface-intended-for-implants
#2
Sebastian Stach, Olga Kędzia, Żaneta Garczyk, Zygmunt Wróbel
The main goal of the study was to develop a model of the degree of surface porosity of a biomaterial intended for implants. The model was implemented using MATLAB. A computer simulation was carried out based on the developed model, which resulted in a two-dimensional image of the modelled surface. Then, an algorithm for computerised image analysis of the surface of the actual oxide bioceramic layer was developed, which enabled determining its degree of porosity. In order to obtain the confocal micrographs of a few areas of the biomaterial, measurements were performed using the LEXT OLS4000 confocal laser microscope...
May 18, 2018: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/29752092/a-novel-porous-bioceramic-scaffold-by-accumulating-hydroxyapatite-spheres-for-large-bone-tissue-engineering-iii-characterization-of-porous-structure
#3
Jingwei Zhang, Dongqin Xiao, Xu He, Feng Shi, Pinfeng Luo, Wei Zhi, Ke Duan, Jie Weng
Physical characteristics of bone tissue engineering scaffolds, including interconnectivity, microporosity, macroporosity, and pore geometry are known to play a crucial role in bone regeneration. In the present study, three-dimensional (3D) interconnected scaffolds were prepared by accumulating hydroxyapatite (HA) spheres in a titanium mesh tube (ф 1.5 × 3 cm). Three types of porous scaffolds were constructed using HA spheres with diameters of 1651-1981 μm, 830-1180 μm and a mixture of 1651-1981 μm and 830-1180 μm at a volumetric ratio of 1:1, respectively...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29747030/the-osteogenic-inflammatory-and-osteo-immunomodulatory-performances-of-biomedical-ti-ta-metal-metal-composite-with-ca-and-si-containing-bioceramic-coatings
#4
Qianli Huang, Xuezhong Li, Tarek A Elkhooly, Shenghang Xu, Xujie Liu, Qingling Feng, Hong Wu, Yong Liu
It is known that good mechanical properties, low modulus to reduce stress-shielding effect, favorable osteogenic activity and limited inflammatory response are critical factors for orthopedic implants to induce excellent osteointegration. In this study, Ti-20% Ta metal-metal composite (referred as Ti-Ta) which consisted of Ti- and Ta-rich phases was fabricated via the strategy of powder metallurgy. Micro-arc oxidation (MAO) was employed to modify the surface of Ti-Ta composite. The surfaces of Ti-Ta composite after MAO treatment at an applied voltage of 250 (referred as MAO-250 V) or 300 V (referred as MAO-300 V) exhibited three distinct zones with significantly different morphological features and surface chemistry...
May 5, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29744460/antibacterial-forsterite-mg-2-sio-4-scaffold-a-promising-bioceramic-for-load-bearing-applications
#5
Rajan Choudhary, Ankita Chatterjee, Senthil Kumar Venkatraman, Sivasankar Koppala, Jayanthi Abraham, Sasikumar Swamiappan
In the current work, forsterite samples with different surface area were investigated for its antibacterial activity. Dissolution studies show that the lower degradation of forsterite compared to other silicate bioceramics, which is a desirable property for repairing bone defects. Forsterite scaffold shows superior compressive strength than the cortical bone after immersion in simulated body fluid. Bactericidal tests indicate that the forsterite had inhibition effect on the growth of clinical bacterial isolates...
September 2018: Bioactive Materials
https://www.readbyqxmd.com/read/29744450/the-development-of-collagen-based-composite-scaffolds-for-bone-regeneration
#6
REVIEW
Dawei Zhang, Xiaowei Wu, Jingdi Chen, Kaili Lin
Bone is consisted of bone matrix, cells and bioactive factors, and bone matrix is the combination of inorganic minerals and organic polymers. Type I collagen fibril made of five triple-helical collagen chains is the main organic polymer in bone matrix. It plays an important role in the bone formation and remodeling process. Moreover, collagen is one of the most commonly used scaffold materials for bone tissue engineering due to its excellent biocompatibility and biodegradability. However, the low mechanical strength and osteoinductivity of collagen limit its wider applications in bone regeneration field...
March 2018: Bioactive Materials
https://www.readbyqxmd.com/read/29744438/an-overview-of-graphene-based-hydroxyapatite-composites-for-orthopedic-applications
#7
REVIEW
Ming Li, Pan Xiong, Feng Yan, Sijie Li, Changhong Ren, Zhichen Yin, Ang Li, Huafang Li, Xunming Ji, Yufeng Zheng, Yan Cheng
Hydroxyapatite (HA) is an attractive bioceramic for hard tissue repair and regeneration due to its physicochemical similarities to natural apatite. However, its low fracture toughness, poor tensile strength and weak wear resistance become major obstacles for potential clinical applications. One promising method to tackle with these problems is exploiting graphene and its derivatives (graphene oxide and reduced graphene oxide) as nanoscale reinforcement fillers to fabricate graphene-based hydroxyapatite composites in the form of powders, coatings and scaffolds...
March 2018: Bioactive Materials
https://www.readbyqxmd.com/read/29744426/high-velocity-suspension-flame-spraying-hvsfs-of-metal-doped-bioceramic-coatings
#8
P Krieg, A Killinger, R Gadow, S Burtscher, A Bernstein
•Bioceramic coatings doped with metals for antibacterial effect.•Combination of suspension and precursor flame spraying.•Successful deposition of submicron metallic particles in bioceramic matrix.
September 2017: Bioactive Materials
https://www.readbyqxmd.com/read/29744418/bioactivation-of-titanium-dioxide-scaffolds-by-alp-functionalization
#9
A Sengottuvelan, P Balasubramanian, J Will, A R Boccaccini
Three dimensional TiO2 scaffolds are receiving renewed attention for bone tissue engineering (TE) due to their biocompatibility and attractive mechanical properties. However the bioactivity of these scaffolds is comparatively lower than that of bioactive glass or hydroxyapatite (HA) scaffolds. One strategy to improve bioactivity is to functionalize the surface of the scaffolds using biomolecules. Alkaline phosphatase (ALP) was chosen in this study due to its important role in the bone mineralization process...
June 2017: Bioactive Materials
https://www.readbyqxmd.com/read/29737429/properties-of-calcium-silicate-monobasic-calcium-phosphate-materials-for-endodontics-containing-tantalum-pentoxide-and-zirconium-oxide
#10
Fausto Zamparini, Francesco Siboni, Carlo Prati, Paola Taddei, Maria Giovanna Gandolfi
OBJECTIVE: The aim of the study was to evaluate chemical-physical properties and apatite-forming ability of three premixed calcium silicate materials containing monobasic calcium phosphate (CaH4 P2 O8 ) bioceramic, tantalum pentoxide and zirconium oxide, recently marketed for endodontics (TotalFill BC-Sealer, BC-RRM-Paste, BC-RRM-Putty). MATERIALS AND METHODS: Microchemical and micromorphological analyses, radiopacity, initial and final setting times, calcium release and alkalising activity were tested...
May 8, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29736384/a-technology-developed-from-concept-of-acupuncture-and-meridian-system-the-clinical-effect-of-bioceramic-resonance-on-psychological-related-sleep-disturbance-with-findings-on-questionnaire-eeg-and-fmri
#11
Lei Zhang, Paul Chan, Zhong Min Liu, Yi Li Tseng, C Will Chen, Ming Tse Lin, Wing P Chan, Ting-Kai Leung
Under the concept of meridian channels that belongs to traditional Chinese medicine, BIOCERAMIC Resonance (BR) has already been applied to many clinical medical research projects with functions mimicking of traditional acupuncture. Forty-five patients were recruited with chronic sleep disorders; 36 patients were given, applied to the device with BIOCERAMIC material and sound rhythm on chest skin surface; 9 patients were included as controls. All study participants completed a sleep pattern and quality of life questionnaire (assessment on psychological and physical causes of sleep disturbances), which was repeated before, during and after treatment...
April 2018: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29717475/antibacterial-anti-inflammatory-and-bone-regenerative-dual-drug-loaded-calcium-phosphate-nanocarriers-in-vitro-and-in-vivo-studies
#12
K Madhumathi, Y Rubaiya, Mukesh Doble, R Venkateswari, T S Sampath Kumar
A dual local drug delivery system (DDS) composed of calcium phosphate bioceramic nanocarriers aimed at treating the antibacterial, anti-inflammatory, and bone-regenerative aspects of periodontitis has been developed. Calcium-deficient hydroxyapatite (CDHA, Ca/P = 1.61) and tricalcium phosphate (β-TCP) were prepared by microwave-accelerated wet chemical synthesis method. The phase purity of the nanocarriers was confirmed by x-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FT-IR), while the transmission electron microscopy (TEM) confirmed their nanosized morphology...
May 1, 2018: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29714700/bioactive-endodontic-materials-for-everyday-use-a-review
#13
Ryan M Walsh, Jianing He, Jordan Schweitzer, Lynne A Opperman, Karl F Woodmansey
Bioceramic materials are at the forefront of modern dentistry. Bioactive bioceramic endodontic materials promote pulpal and periapical tissue healing and are easy to use. Dentists can choose among many endodontic materials, depending on their needs. This article highlights the major differences among commercially available bioactive tricalcium silicate bioceramics, commonly known as mineral trioxide aggregate materials, to enable dentists to make appropriate decisions in the selection of these materials.
May 2018: General Dentistry
https://www.readbyqxmd.com/read/29703593/ball-milling-of-eggshell-waste-as-a-green-and-sustainable-approach-a-review
#14
REVIEW
Matej Baláž
Eggshell waste belongs to the most abundant natural waste in nature and is created in huge amounts by everyday consumption of eggs. The majority of this material is being discarded, despite the fact that it has multidisciplinary applications. In this review, the possibility of utilizing the method of ball milling to further broaden the application potential of this material is discussed. The particular application fields include the formation of nanophases, bioceramics synthesis, formation of composites and preparation of material with increased sorption ability...
April 17, 2018: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/29691828/silk-fibroin-based-hydrogels-and-scaffolds-for-osteochondral-repair-and-regeneration
#15
Viviana P Ribeiro, Sandra Pina, J Miguel Oliveira, Rui L Reis
Osteochondral lesions treatment and regeneration demands biomimetic strategies aiming physicochemical and biological properties of both bone and cartilage tissues, with long-term clinical outcomes. Hydrogels and scaffolds appeared as assertive approaches to guide the development and structure of the new osteochondral engineered tissue. Moreover, these structures alone or in combination with cells and bioactive molecules bring the mechanical support after in vitro and in vivo implantation. Moreover, multilayered structures designed with continuous interfaces furnish appropriate features of the cartilage and subchondral regions, namely microstructure, composition, and mechanical properties...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29691817/bioceramics-for-osteochondral-tissue-engineering-and-regeneration
#16
Sandra Pina, Rita Rebelo, Vitor Manuel Correlo, J Miguel Oliveira, Rui L Reis
Considerable advances in tissue engineering and regeneration have been accomplished over the last decade. Bioceramics have been developed to repair, reconstruct, and substitute diseased parts of the body and to promote tissue healing as an alternative to metallic implants. Applications embrace hip, knee, and ligament repair and replacement, maxillofacial reconstruction and augmentation, spinal fusion, bone filler, and repair of periodontal diseases. Bioceramics are well-known for their superior wear resistance, high stiffness, resistance to oxidation, and low coefficient of friction...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29691815/natural-origin-materials-for-osteochondral-tissue-engineering
#17
Walter Bonani, Weerasak Singhatanadgige, Aramwit Pornanong, Antonella Motta
Materials selection is a critical aspect for the production of scaffolds for osteochondral tissue engineering. Synthetic materials are the result of man-made operations and have been investigated for a variety of tissue engineering applications. Instead, the products of physiological processes and the metabolic activity of living organisms are identified as natural materials. Over the recent decades, a number of natural materials, namely, biopolymers and bioceramics, have been proposed as the main constituent of osteochondral scaffolds, but also as cell carriers and signaling molecules...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29687593/incorporating-si-3-n-4-into-peek-to-produce-antibacterial-osteocondutive-and-radiolucent-spinal-implants
#18
Giuseppe Pezzotti, Elia Marin, Tetsuya Adachi, Federica Lerussi, Alfredo Rondinella, Francesco Boschetto, Wenliang Zhu, Takashi Kitajima, Kosuke Inada, Bryan J McEntire, Ryan M Bock, B Sonny Bal, Osam Mazda
Polyetheretherketone (PEEK) is a popular polymeric biomaterial which is primarily used as an intervertebral spacer in spinal fusion surgery; but it is developed for trauma, prosthodontics, maxillofacial, and cranial implants. It has the purported advantages of an elastic modulus which is similar to native bone and it can be easily formed into custom 3D shapes. Nevertheless, PEEK's disadvantages include its poor antibacterial resistance, lack of bioactivity, and radiographic transparency. This study presents a simple approach to correcting these three shortcomings while preserving the base polymer's biocompatibility, chemical stability, and elastic modulus...
April 24, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29678674/the-role-of-the-micro-pattern-and-nano-topography-of-hydroxyapatite-bioceramics-on-stimulating-osteogenic-differentiation-of-mesenchymal-stem-cells
#19
Cancan Zhao, Xiaoya Wang, Long Gao, Linguo Jing, Quan Zhou, Jiang Chang
The micro/nano hybrid structure is considered to be a biomaterial characteristic to stimulate osteogenesis by mimicking the three-dimensional structure of the bone matrix. However, the mechanism of the hybrid structure induced osteogenic differentiation of stem cells is still unknown. For elucidating the mechanisms, one of the challenge is to directly fabricate micro/nano hybrid structure on bioceramics because of its brittleness. In this study, hydroxyapatite (HA) bioceramics with the micro/nano hybrid structure were firstly fabricated via a hydrothermal treatment and template method, and the effect of the different surface structures on the expression of integrins, BMP2 signaling pathways and cell-cell communication was investigated...
April 17, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29674822/evaluation-of-bioceramics-and-zirconia-reinforced-glass-ionomer-cement-in-repair-of-furcation-perforations-an-in-vitro-study
#20
Anish Kumar Lagisetti, Priyadarshini Hegde, Mithra Nidarsh Hegde
Aim: The aim and objective of this study was to evaluate and compare the sealing ability of EndoSequence BC RRM-fast set putty, Proroot mineral trioxide aggregate (MTA), and Zirconomer in the repair of furcal perforation by measuring dye leakage under stereomicroscope. Methodology: A standard access cavity was made on forty-eight extracted mandibular and maxillary first molars followed by creating a furcal perforation in the center of the pulp chamber by using No...
March 2018: Journal of Conservative Dentistry: JCD
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