sexual obsession cases in schizophrenia

BACKGROUND: Obsessions, compulsions, and stereotypes are common psychopathological manifestations of obsessive-compulsive, psychotic, and autism spectrum disorders (ASDs). These nosological entities may be present in comorbidity, with relevant clinical difficulties in the differential diagnosis process. Moreover, ASDs are a complex group of disorders, with a childhood onset, which also persist into adulthood and present heterogeneous symptom patterns that could be confused with psychotic disorders...

The oxytocin receptor (OXTR), encoded by the OXTR gene, is responsible for the signal transduction after binding its ligand, oxytocin. Although this signaling is primarily involved in controlling maternal behavior, it was demonstrated that OXTR also plays a role in the development of the nervous system. Therefore, it is not a surprise that both the ligand and the receptor are involved in the modulation of behaviors, especially those related to sexual, social, and stress-induced activities. As in the case of every regulatory system, any disturbances in the structures or functions of oxytocin and OXTR may lead to the development or modulation of various diseases related to the regulated functions, which in this case include either mental problems (autism, depression, schizophrenia, obsessive-compulsive disorders) or those related to the functioning of reproductive organs (endometriosis, uterine adenomyosis, premature birth)...

Child sexual abuse (CSA) occurs when a person involves the child in sexual activities for his/her sexual gratification, commercial gain, or both. We report a series of 12 cases of CSA, who presented to the psychiatry department with diverse psychiatric presentations associated with CSA. In most of these cases, the perpetrator was unmarried and known to the child. The presentation was varied with patients being diagnosed with obsessive-compulsive disorder, schizophrenia, acute and transient psychotic disorder, dysthymic disorder, recurrent depressive disorder, acute stress reaction, conversion disorder, borderline personality disorder, and moderate depressive episode with somatic symptoms...

BACKGROUND: All current approved antipsychotic drugs against schizophrenia spectrum disorders share affinity for the dopamine receptor (D2R). However, up to one-third of these patients respond insufficiently, and in some cases, side-effects outweigh symptom reduction. Previous data have suggested that a subgroup of antipsychotic-naïve patients will respond to serotonin 2A receptor (2AR) blockade. AIMS: This investigator-initiated, translational, proof-of-concept study has overall two aims; 1) To test the clinical effectiveness of monotherapy with the newly approved drug against Parkinson's disease psychosis, pimavanserin, in antipsychotic-free patients with first-episode schizophrenia spectrum disorders; 2) To characterize the neurobiological profile of responders to pimavaserin...

A substantial delay for help-seeking is a serious problem for people with obsessive-compulsive disorder (OCD), a heterogeneous and debilitating mental health condition. Stigma is a major barrier to treatment seeking and further cause social and occupational impairment. Lack of comprehensive research led us to examine the public's stigmatizing attitudes towards checking, contamination, sexuality, aggression, and religion-related OCD symptoms, compared to schizophrenia. After reading one of six random case vignettes, 621 adults completed social distance scale...

BACKGROUND: Mirtazapine is an antidepressant first approved in the Netherlands in 1994 for the treatment of major depressive disorder. However, evidence suggests its effectiveness in a variety of other psychiatric disorders and non-psychiatric medical conditions. OBJECTIVE: The present paper reviews the published literature on the off-label indications of Mirtazapine. METHODS: A search of the relevant literature from MEDLINE, PsycLIT and EMBASE databases, included in the Science Citation Index and available up to March 2006, was conducted using the terms mirtazapine, case-reports, open-label trials and randomized controlled trials...

OBJECTIVE: To study the prevalence, phenomenology and course of OCS/OCD in patients receiving clozapine. METHODOLOGY: Case records of 220 patients who received clozapine for at least 3 months were reviewed. RESULTS: One fifth (N=42; 19.1%) of patients had OCS/OCD, of which majority (13.2%) had onset of OCS/OCD prior to starting of clozapine and remaining 5.9% developed OCS/OCD after starting of clozapine. About one fourth of the patients with pre-existing OCS/OCD had worsening with clozapine while the remaining maintained at the same level (55...

AIM: The aim of the paper was to present the basic data about delusions of sex change and body dysmorphic disorder and describe two cases of patients with these symptoms and paranoid schizophrenia. METHOD: Analysis of the course of illness and medical documentation. RESULTS: Coexisting of transsexualism and schizophrenia cause a lot of doubt. Moreover, delusions of sex change are probably more frequent than it is thought. It causes that in some cases the differential diagnosis of psychosis and gender identity disorders may be very difficult...

200 schizophrenic patients (130 men, 70 women), which had fallen ill at the age of 4-25 years were examined in outpatient clinic. Either on the separate stages of the disease or during all its course the patients had the following impuls-control disorders: of eating--14 patients (7.0%), sexual drive--56 cases (28.0%), self-preservation--37 (18.5%), alcoholism--76 (38.0%), dromomania--38 (19.0%), pyromania--2 (1.0%), kleptomania--4 (2.0%). By the mechanisms of the disorders' development there were impulsive, obsessive and compulsive ones...

The frontal lobes can be subdivided into major functional neuroanatomical domains, which, when injured, surgically destroyed, or reduced in activity or volume, give rise to signature pathological and psychiatric symptomology. A review of case reports and over 50 years of research, including magnetic resonance imaging, positron emission tomography, and single photon emission computed tomography scans, indicates that apathy, "blunted" schizophrenia, major depression, and aphasic-perseverative disturbance of speech and thought are associated with left lateral as well as bilateral frontal (and striatal) abnormalities...

72 schizophrenic patients were examined in terms of catamnestic analysis of pathological fantasy and metaphysical intoxication, joint into overvaluable inclination (drive) syndrome. The syndrome dynamics was observed in 36 cases and thus on this basis 6 variations were picked out. There were the following variations: delayed dynamics combined with psychic infantilism; conversion into overvaluable (paranoid) disturbances in "mosaic" psychopathic-like states structure; transition into overvaluable delirium; conversion into obsessions; transition into sexual delusion; and complication of overvaluable inclination because of pseudohallucinations, normal life as well as sexual disturbances addition...

This review brings together the considerable, scattered literature on the sexuality of the schizophrenic. It encompasses the reports pertaining not only to the overt sexual behavior of schizophrenics but also their subjective experience including various delusions and hallucinations related to sexuality. Also reviewed are the sexual side effects of antipsychotic medication and sexual crimes and perversions occurring among individuals suffering from schizophrenia. The effectiveness of various treatment modalitites, including sex therapy, in controlling the bizarre sexual behavior that often accompanies schizophrenia, is also considered...

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