keyword
https://read.qxmd.com/read/38512420/tumor-treating-fields-suppress-tumor-cell-growth-and-neurologic-decline-in-models-of-spine-metastases
#1
JOURNAL ARTICLE
Daniel Ledbetter, Romulo de Almeida, Xizi Wu, Ariel Naveh, Chirag B Patel, Queena Gonzalez, Thomas H Beckham, Robert North, Laurence Rhines, Jing Li, Amol Ghia, David Aten, Claudio Tatsui, Christopher Alvarez-Breckenridge
Spine metastases can result in severe neurologic compromise and decreased overall survival. Despite treatment advances, local disease progression is frequent, highlighting the need for novel therapies. Tumor treating fields (TTFields) impair tumor cell replication and are influenced by properties of surrounding tissue. We hypothesize bone's dielectric properties will enhance TTFields mediated suppression of tumor growth in spine metastasis models. Computational modeling of TTFields intensity was performed following surgical resection of a spinal metastasis and demonstrated enhanced TTFields intensity within the resected vertebral body...
March 21, 2024: JCI Insight
https://read.qxmd.com/read/38481068/theory-and-application-of-ttfields-in-newly-diagnosed-glioblastoma
#2
REVIEW
Ao Yu, Juan Zeng, Jinhui Yu, Shuo Cao, Ailin Li
BACKGROUND: Glioblastoma is the most common primary malignant brain tumor in adults. TTFields is a therapy that use intermediate-frequency and low-intensity alternating electric fields to treat tumors. For patients with ndGBM, the addition of TTFields after the concurrent chemoradiotherapy phase of the Stupp regimen can improve prognosis. However, TTFields still has the potential to further prolong the survival of ndGBM patients. AIM: By summarizing the mechanism and application status of TTFields in the treatment of ndGBM, the application prospect of TTFields in ndbm treatment is prospected...
March 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38473223/development-and-optimisation-of-tumour-treating-fields-ttfields-delivery-within-3d-primary-glioma-stem-cell-like-models-of-spatial-heterogeneity
#3
JOURNAL ARTICLE
Callum G Jones, Aurelie Vanderlinden, Ola Rominiyi, Spencer J Collis
Glioblastoma is an aggressive, incurable brain cancer with poor five-year survival rates of around 13% despite multimodal treatment with surgery, DNA-damaging chemoradiotherapy and the recent addition of Tumour Treating Fields (TTFields). As such, there is an urgent need to improve our current understanding of cellular responses to TTFields using more clinically and surgically relevant models, which reflect the profound spatial heterogeneity within glioblastoma, and leverage these biological insights to inform the rational design of more effective therapeutic strategies incorporating TTFields...
February 21, 2024: Cancers
https://read.qxmd.com/read/38468503/combination-tumor-treating-fields-treatment-for-patients-with-metastatic-non-small-cell-lung-cancer-a-cost-effectiveness-analysis
#4
JOURNAL ARTICLE
Kun Liu, Youwen Zhu, Hong Zhu, Manting Zeng
BACKGROUND: Tumor-treating field (TTFields) was a novel antitumor therapy that provided significant survival for previously treated metastatic non-small cell lung cancer (mNSCLC). The consistency of the cost of the new treatment regimen with its efficacy was the main objective of the study. METHODS: The primary parameters, derived from the Phase 3 LUNAR study, were collected to evaluate the cost and efficacy of TTFields plus standard-of-care (SOC) (immune checkpoint inhibitors [ICIs] and docetaxel [DTX]) or SOC in patients with mNSCLC by establishing a three-state Markov model over a 15-year time horizon...
March 2024: Cancer Medicine
https://read.qxmd.com/read/38455403/-tumor-treating-fields-delivered-via-electromagnetic-induction-have-varied-effects-across-glioma-cell-lines-and-electric-field-amplitudes
#5
JOURNAL ARTICLE
Rea Ravin, Teddy X Cai, Aiguo Li, Nicole Briceno, Randall H Pursley, Marcial Garmendia-Cedillos, Tom Pohida, Herui Wang, Zhengping Zhuang, Jing Cui, Nicole Y Morgan, Nathan H Williamson, Mark R Gilbert, Peter J Basser
Previous studies reported that alternating electric fields (EFs) in the intermediate frequency (100-300 kHz) and low intensity (1-3 V/cm) regime - termed "Tumor Treating Fields" (TTFields) - have a specific, anti-proliferative effect on glioblastoma multiforme (GBM) cells. However, the mechanism(s) of action remain(s) incompletely understood, hindering the clinical adoption of treatments based on TTFields. To advance the study of such treatment in vitro , we developed an inductive device to deliver EFs to cell cultures which improves thermal and osmolar regulation compared to prior devices...
2024: American Journal of Cancer Research
https://read.qxmd.com/read/38417178/impact-of-glioma-peritumoral-edema-tumor-size-and-tumor-location-on-alternating-electric-fields-aef-therapy-in-realistic-3d-rat-glioma-models-a-computational-study
#6
JOURNAL ARTICLE
Ha Nguyen, Keith E Schubert, Christoph Pohling, Edwin Chang, Vicky Yamamoto, Yuping Zeng, Ying Nie, Samuel Lee Van Buskirk, Reinhard W Schulte, Chirag B Patel
OBJECTIVE: Alternating electric fields (AEF) therapy is a treatment modality for patients with glioblastoma. Tumor characteristics such as size, location, and extent of peritumoral edema may affect the AEF strength and distribution. We evaluated the sensitivity of the AEFs in a realistic 3D rat glioma model with respect to these properties. APPROACH: The electric properties of the peritumoral edema were varied based on calculated and literature-reported values. Models with different tumor composition, size, and location were created...
February 28, 2024: Physics in Medicine and Biology
https://read.qxmd.com/read/38396172/tumor-treating-fields-ttfields-combined-with-the-drug%C3%A2-repurposing-approach-cusp9v3-induce-metabolic-reprogramming-and-synergistic-anti-glioblastoma-activity-in-vitro
#7
JOURNAL ARTICLE
Qiyu Cao, Annika Hajosch, Richard Eric Kast, Christopher Loehmann, Michal Hlavac, Pamela Fischer-Posovszky, Hannah Strobel, Mike-Andrew Westhoff, Markus D Siegelin, Christian Rainer Wirtz, Marc-Eric Halatsch, Georg Karpel-Massler
BACKGROUND: Glioblastoma represents a brain tumor with a notoriously poor prognosis. First-line therapy may include adjunctive Tumor Treating Fields (TTFields) which are electric fields that are continuously delivered to the brain through non-invasive arrays. On a different note, CUSP9v3 represents a drug repurposing strategy that includes 9 repurposed drugs plus metronomic temozolomide. Here, we examined whether TTFields enhance the antineoplastic activity of CUSP9v3 against this disease...
February 23, 2024: British Journal of Cancer
https://read.qxmd.com/read/38349201/advancements-and-current-trends-in-tumor-treating-fields-a-scientometric-analysis
#8
JOURNAL ARTICLE
Yang Xing, Feroza Yasinjan, Jiayue Cui, Yizhao Peng, Minghua He, Wenhui Liu, Xinyu Hong
Tumor treating fields (TTFields) therapy is a novel and effective non-invasive cancer therapy, and it has been approved by FDA in the treatment of recurrent and newly diagnosed glioblastoma, and malignant pleural mesothelioma. Moreover, TTFields therapy has been widely studied in both clinical trials and preclinical studies in recent years. Based on its high efficacy, research on TTFields therapy has been a hot topic. Thus, we made this scientometric analysis of TTfields to reveal the scientometric distributions such as annual publications and citations, countries and institutions, authors, journals, references, and more importantly, research status and hot topics of the field...
February 13, 2024: International Journal of Surgery
https://read.qxmd.com/read/38288093/tumor-treating-fields-ttfields-for-spinal-metastasis-the-case-for-bone-removal-and-spinal-implants-as-waveguides-to-enhance-field-strength-at-the-target
#9
JOURNAL ARTICLE
Claudio E Tatsui, Kristen W Carlson, Chirag B Patel
No abstract text is available yet for this article.
2024: Neuro-oncology advances
https://read.qxmd.com/read/38260214/body-fluids-modulate-propagation-of-tumor-treating-fields
#10
REVIEW
Eric T Wong, Edwin Lok
Tumor treating fields (TTFields) are nonionizing alternating electric fields that have anticancer properties. After the initial approval for use in patients with recurrent glioblastoma in 2011 and newly diagnosed glioblastomas in 2015, they are now being tested in those with advanced lung cancer, ovarian carcinoma, and pancreatic cancer. Unlike ionizing radiation therapy, TTFields have nonlinear propagation characteristics; therefore, it is difficult for clinicians to recognize intuitively the location where these fields have the most impact...
January 2024: Advances in Radiation Oncology
https://read.qxmd.com/read/38195076/case-report-durable-response-of-gliomatosis-cerebri-with-concurrent-tumor-treating-fields-ttfields-and-chemoradiotherapy-treatment
#11
Alex M DesJarlais, Ryan Miller, Ayesha S Ali, Muneeb Z Niazi, Louis Cappelli, Jon Glass, Christopher J Farrell, Wenyin Shi
BACKGROUND: Gliomatosis cerebri (GC) is a rare and aggressive form of widely disseminated glioma infiltrating at least 3 lobes of the brain. It is a diffuse pattern of growth seen in glioma rather than a distinct pathological diagnosis based on new Word Health Organization (WHO) classification. Despite this, it is associated with worse prognosis than equally graded gliomas. Tumor treating fields (TTFields) treatment is a more recent advancement in glioma treatment delivered through low energy, intermediate frequency (200 kHz) electromagnetic fields, with multi-modal mechanisms of action...
December 2023: Chinese Clinical Oncology
https://read.qxmd.com/read/38149153/influence-of-tumor-treating-fields-in-a-young-patient-with-primary-spinal-glioblastoma-multiforme-gbm-a-case-report-of-a-rare-tumor
#12
Emmanuel K Mikobi, Gerard Voorhees, Aftab Mahmood, Arpit Gandhi, Michael Bailey, Jacqueline Phillips
We present a 31-year-old female patient with primary glioblastoma multiforme (GBM) of the thoracic spine, diagnosed in approximately mid-2020. Her symptoms began several months prior with right foot paresthesia, which progressed to neuropathy ascending from her distal to proximal right lower extremity. Over several months, she developed lumbo-thoracic throbbing pain, which was dermatomal radiating anteriorly. Her pain worsened with activity. A thoracic spine MRI showed a focus of abnormal intradural intramedullary enhancement present from the T10-T11 disc level to the T12-L1 disc level, producing a large amount of edema within the cord...
November 2023: Curēus
https://read.qxmd.com/read/38125027/glioblastoma-behavior-study-under-different-frequency-electromagnetic-field
#13
JOURNAL ARTICLE
Xiao-Wei Xiang, Hao-Tian Liu, Xiao-Nan Tao, Yu-Lian Zeng, Jing Liu, Chen Wang, Sai-Xi Yu, Hui Zhao, Yan-Jun Liu, Ke-Fu Liu
The tumor-treating fields (TTFields) technology has revolutionized the management of recurrent and newly diagnosed glioblastoma (GBM) cases. To ameliorate this treatment modality for GBM and other oncological conditions, it is necessary to understand the biophysical principles of TTFields better. In this study, we further analyzed the mechanism of the electromagnetic exposure with varying frequencies and electric field strengths on cells in mitosis, specifically in telophase. In reference to previous studies, an intuitive finite element model of the mitotic cell was built for electromagnetic simulations, predicting a local increase in the cleavage furrow region, which may help explain TTFields' anti-proliferative effects...
December 15, 2023: IScience
https://read.qxmd.com/read/38094629/tumor-treating-fields-ttfields-demonstrate-antiviral-functions-in-vitro-and-safety-for-application-to-covid-19-patients-in-a-pilot-clinical-study
#14
JOURNAL ARTICLE
Avraham Abutbul, Helena Mumblat, Yaara Porat, Nehemya Friedman, Nofar Atari, Shirley Sharabi, Ahmad Nama, Waseem Mugahed, Asa Kessler, Yotam Kolben, Reuben Ruby Shamir, Doron Manzur, Ori Farber, Liora Bosch, Gitit Lavy-Shahaf, Eyal Dor-On, Adi Haber, Moshe Giladi, Uri Weinberg, Yoram Palti, Yael Mardor, Michal Mandelboim
Coronaviruses are the causative agents of several recent outbreaks, including the COVID-19 pandemic. One therapeutic approach is blocking viral binding to the host receptor. As binding largely depends on electrostatic interactions, we hypothesized possible inhibition of viral infection through application of electric fields, and tested the effectiveness of Tumor Treating Fields (TTFields), a clinically approved cancer treatment based on delivery of electric fields. In preclinical models, TTFields were found to inhibit coronavirus infection and replication, leading to lower viral secretion and higher cell survival, and to formation of progeny virions with lower infectivity, overall demonstrating antiviral activity...
2023: Frontiers in Microbiology
https://read.qxmd.com/read/38067345/research-progress-on-the-mechanism-of-anti-tumor-immune-response-induced-by-ttfields
#15
REVIEW
Yue Lan, Shaomin Zhang, Yun Pan, Minmin Wang, Guangdi Chen
Tumor treating fields (TTFields), a biophysical therapy technology that uses alternating electric fields to inhibit tumor proliferation, has been approved by the U.S. Food and Drug Administration (FDA) for the treatment of newly diagnosed or recurrent glioblastomas (GBM) and malignant pleural mesotheliomas (MPM). Clinical trials have confirmed that TTFields are effective in slowing the tumor growth and prolonging patient survival. In recent years, many researchers have found that TTFields can induce anti-tumor immune responses, and their main mechanisms include upregulating the infiltration ratio and function of immune cells, inducing the immunogenic cell death of tumor cells, modulating immune-related signaling pathways, and upregulating the expression of immune checkpoints...
November 29, 2023: Cancers
https://read.qxmd.com/read/38058802/tumor-treating-fields-induced-senescence-on-glioblastoma
#16
JOURNAL ARTICLE
Eun Ho Kim
Innovative approaches have given rise to a method for treating newly diagnosed GBM cancer patients within a span of 4.9 months, resulting in improved median overall survival (OS) and minimal side effects during the phase III clinical trial. This approach is referred to as Tumor Treating Fields (TTFields). The objective of this study is to ascertain the potential of TTFields treatment in sensitizing GBM cancer cells by enhancing TTFields-induced senescence. To achieve this, the research employed a multifaceted methodology that encompassed several elements, including the analysis of SA-β-gal staining, flow cytometry, Western blotting, morphology assessment, Positron Emission Tomography (PET)/Computed Tomography (CT), immunohistochemical staining, and microassay...
2023: American Journal of Cancer Research
https://read.qxmd.com/read/38053701/tumor-treating-fields-for-the-treatment-of-glioblastoma-current-understanding-and-future-perspectives
#17
REVIEW
Antonio Colamaria, Augusto Leone, Nicola Pio Fochi, Veronica Di Napoli, Guido Giordano, Matteo Landriscina, Kashyap Patel, Francesco Carbone
BACKGROUND: This review focuses on the recently published evidence on tumor treating fields (TTFields) administered alone or in combination with locoregional and systemic options for treating glioblastoma (GBM) in the past ten years. The aim is to critically summarize the novelty and results obtained with this innovative tool, which is becoming part of the armamentarium of neurosurgeons and neuro-oncologists. METHODS: A comprehensive search and analysis were conducted on pivotal studies published in the past ten years...
2023: Surgical Neurology International
https://read.qxmd.com/read/38050252/efficacy-of-tumour-treating-fields-therapy-in-recurrent-glioblastoma-a-narrative-review-of-current-evidence
#18
REVIEW
Gbolahan Olatunji, Nicholas Aderinto, Temiloluwa Adefusi, Emmanuel Kokori, Olumide Akinmoju, Ismaila Yusuf, Tobi Olusakin, Muhammad Ali Muzammil
Recurrent Glioblastoma presents a formidable challenge in oncology due to its aggressive nature and limited treatment options. Tumour-Treating Fields (TTFields) Therapy, a novel therapeutic modality, has emerged as a promising approach to address this clinical conundrum. This review synthesizes the current evidence surrounding the efficacy of TTFields Therapy in the context of recurrent Glioblastoma. Diverse academic databases were explored to identify relevant studies published within the last decade. Strategic keyword selection facilitated the inclusion of studies focusing on TTFields Therapy's efficacy, treatment outcomes, and patient-specific factors...
December 1, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/37955637/treatment-with-tumor-treating-fields-ttfields-suppresses-intercellular-tunneling-nanotube-formation-in-vitro-and-upregulates-immuno-oncologic-biomarkers-in-vivo-in-malignant-mesothelioma
#19
JOURNAL ARTICLE
Akshat Sarkari, Sophie Korenfeld, Karina Deniz, Katherine Ladner, Phillip Wong, Sanyukta Padmanabhan, Rachel I Vogel, Laura A Sherer, Naomi Courtemanche, Clifford Steer, Kerem Wainer-Katsir, Emil Lou
Disruption of intercellular communication within tumors is emerging as a novel potential strategy for cancer-directed therapy. Tumor-Treating Fields (TTFields) therapy is a treatment modality that has itself emerged over the past decade in active clinical use for patients with glioblastoma and malignant mesothelioma, based on the principle of using low-intensity alternating electric fields to disrupt microtubules in cancer cells undergoing mitosis. There is a need to identify other cellular and molecular effects of this treatment approach that could explain reported increased overall survival when TTFields are added to standard systemic agents...
November 13, 2023: ELife
https://read.qxmd.com/read/37953242/tumor-treating-fields-narrative-review-of-a-promising-treatment-modality-for-cancer
#20
JOURNAL ARTICLE
Tugce Kutuk, Ece Atak, Alonso La Rosa, Rupesh Kotecha, Minesh P Mehta, Michael D Chuong
BACKGROUND AND OBJECTIVE: Tumor treating fields (TTFields) therapy have emerged as a potentially effective treatment for various malignancies by delivering low-intensity, intermediate-frequency electrical fields that disrupt many processes inside cells, resulting in the interruption of cell division in cancer cells. Additionally, TTFields therapy has been found to be synergistic with existing therapeutic approaches. In this review, we provide an introduction and background to the primary mechanisms of TTFields and discuss the emerging preclinical and clinical outcomes of this novel cancer treatment technology...
November 2, 2023: Chinese Clinical Oncology
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