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Acute mesenteric ischemia

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https://www.readbyqxmd.com/read/29776790/-modern-treatment-of-mesenteric-ischemia
#1
Alexandre Nuzzo, Audrey Huguet, Olivier Corcos
Acute mesenteric ischemia is a highly morbid affliction which requires urgent care. Acute mesenteric ischemia consists in an ischemia injury of the small bowel, secondary to vascular insufficiency, either occlusive (thrombosis, embolism, arterial, venous) or non-occlusive (low flow or vasospasm). Given that the superior mesenteric artery supplies the small bowel as well as the right part of the colon, any ischemic process involving the right colon should be considered an acute mesenteric ischemia until proven otherwise...
May 15, 2018: La Presse Médicale
https://www.readbyqxmd.com/read/29771572/inhibition-of-ubiquitin-activating-enzyme-protects-against-organ-injury-after-intestinal-ischemia-reperfusion
#2
Shingo Matsuo, Andrew Chaung, Deanna Liou, Ping Wang, Weng-Lang Yang
Intestinal ischemia-reperfusion (I/R) occurs in various clinical settings, such as transplantation, acute mesenteric arterial occlusion, trauma and shock. I/R injury causes severe systemic inflammation, leading to multiple organ dysfunction associated with high mortality. The ubiquitin proteasome pathway has been indicated in the regulation of inflammation, particularly through NF-κB signaling pathway. PYR-41 is a small molecular compound that selectively inhibits ubiquitin-activating enzyme E1. A mouse model of intestinal I/R injury by clamping the superior mesenteric artery for 45 minutes was performed to evaluate the effect of PYR-41 treatment on organ injury and inflammation...
May 17, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29767265/knockdown-of-tnf%C3%A2-%C3%AE-alleviates-acute-lung-injury-in-rats-with-intestinal-ischemia-and-reperfusion-injury-by-upregulating-il%C3%A2-10-expression
#3
Zhen Yang, Xue-Rong Zhang, Qiong Zhao, Sheng-Lan Wang, Liu-Lin Xiong, Piao Zhang, Bing Yuan, Zi-Bing Zhang, Shu-Yuan Fan, Ting-Hua Wang, Yun-Hui Zhang
Intestinal ischemia and reperfusion (II/R) injury often triggers severe injury in remote organs, with the lungs being considered the main target. Excessive elevation of proinflammatory cytokines is a major contributor in the occurrence and development of II/R‑induced acute lung injury (ALI). Therefore, the present study aimed to investigate whether blocking tumor necrosis factor‑α (TNF‑α) expression could protect the lungs from injury following II/R, and to explore the possible underlying mechanism involving interleukin‑10 (IL‑10)...
May 14, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29758324/exertional-abdominal-pain-as-a-rare-presenting-manifestation-of-chronic-mesenteric-ischemia-from-a-single-mesenteric-vessel-stenosis
#4
Heepeel Chang, Neal C Hadro, Marc A Norris, Marvin E Morris
We present an atypical manifestation of chronic mesenteric ischemia in a patient with progressively worsening exertional abdominal pain. Imaging modalities revealed significant isolated stenosis of superior mesenteric artery. Successful angioplasty and stenting of superior mesenteric artery relieved patient's symptoms, thereby confirming the diagnosis of CMI. Exertional abdominal pain may be a unique manifestation of this disease, but when it presents, clinicians should have acute clinical awareness of this diagnosis...
May 11, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29757725/acute-mesenteric-ischemia-multidetector-ct-findings-and-endovascular-management
#5
Shuzo Kanasaki, Akira Furukawa, Kanako Fumoto, Yasuyo Hamanaka, Shinichi Ota, Tomohiro Hirose, Akitoshi Inoue, Takako Shirakawa, Linh Dai Hung Nguyen, Syerikjan Tulyeubai
Acute mesenteric ischemia is a rare life-threatening condition that accounts for approximately one in 1000 hospital admissions. The mortality rate is 50%-69% owing to the absence of specific symptoms and laboratory data, which makes early detection of this condition difficult. If the use of contrast material is possible, biphasic contrast material-enhanced multidetector computed tomography (CT) is the first-line imaging test for early diagnosis of the disease and for differentiation from other causes of acute abdomen...
May 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29743484/released-mitochondrial-dna-following-intestinal-ischemia-reperfusion-induces-the-inflammatory-response-and-gut-barrier-dysfunction
#6
Qiongyuan Hu, Huajian Ren, Jianan Ren, Qinjie Liu, Jie Wu, Xiuwen Wu, Guanwei Li, Gefei Wang, Guosheng Gu, Kun Guo, Zhiwu Hong, Song Liu, Jieshou Li
Ischemia-reperfusion (I/R) injury is a challenging clinical problem, especially injuries involving the gastrointestinal tract. Mitochondrial DNA (mtDNA) is released upon cell death and stress, and can induce the inflammatory response. We aimed to investigate the role of mtDNA in the pathogenesis of intestinal I/R. Intestinal I/R model was established with clamping of the superior mesenteric artery, and IEC-6 cells were incubated under hypoxia/reoxygenation (H/R) conditions to simulate I/R injury. Using in vitro models, H/R up-regulated oxidative stress, disrupted mitochondrial activity and the mitochondrial membrane potential, induced apoptosis and elevated the mtDNA levels in the supernatant of intestinal epithelial cells, and the co-culture of mtDNA with human primary dendritic cells significantly elevated TLR9-MyD88 expression and enhanced the production of inflammatory cytokines and chemokines...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29701357/frozen-elephant-trunk-with-e-vita-open-hybrid-prosthesis-for-surgical-correction-of-multisegmental-thoracic-aortic-pathology-review-of-results
#7
António Cruz Tomás, Álvaro Laranjeira Santos, Jorge Pinheiro Santos, Daniela Varela-Afonso, José Fragata
INTRODUCTION: The Frozen Elephant Trunk (FET) surgery allows correction of ascending, arch and proximal descending aortic pathology, using a hybrid prosthesis at the same time. It is a complex intervention and requires a multidisciplinary team that, besides scheduling and performing the surgery, accompanies the patient (pt) throughout the postoperative period. OBJECTIVES: To review short and medium term clinical results with this technique. METHODS: Between January 2010 and September 2017, we operated 34 patients (pts) using FET...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29685732/erratum-to-acute-mesenteric-ischemia-a-critical-role-for-the-radiologist-diagn-interv-imaging-99-2018-123-134
#8
P Copin, M Zins, A Nuzzo, Y Purcell, S Beranger-Gibert, L Maggiori, O Corcos, V Vilgrain, M Ronot
No abstract text is available yet for this article.
April 20, 2018: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/29685508/superior-mesenteric-artery-stenting-using-embolic-protection-device-for-treatment-of-acute-or-chronic-mesenteric-ischemia
#9
Bernardo C Mendes, Gustavo S Oderich, Tiziano Tallarita, Karina S Kanamori, Manju Kalra, Randall R DeMartino, Fahad Shuja, Jill K Johnstone
OBJECTIVE: The objective of the study was to report the feasibility and results of superior mesenteric artery (SMA) stenting using embolic protection devices (EPDs) to treat acute mesenteric ischemia (AMI) and chronic mesenteric ischemia (CMI). METHODS: A retrospective review was conducted of consecutive patients who underwent SMA stenting with EPDs from 2007 to 2016. EPDs were used selectively in patients with occlusions, severe calcification, or acute thrombus...
April 20, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29682126/superior-mesenteric-artery-pancreaticoduodenal-arcade-bypass-grafting-for-repair-of-inferior-pancreaticoduodenal-artery-aneurysm-with-celiac-axis-occlusion
#10
Akira Murata, Koji Amaya, Kentaro Mochizuki, Masami Sotokawa, Shingo Otaka, Kazuhiro Tani, Shota Nakagaki, Tetsuyuki Ueda
We report a case of an aneurysm of the inferior pancreaticoduodenal artery (IPDA), with chronic occlusion of the celiac axis. Both surgical aneurysmectomy and endovascular coil embolization were anticipated to sacrifice IPDA, which could lead to severe acute ischemia in the celiac region. The treatment involved surgical ligation of the aneurysm after bypass grafting from the superior mesenteric artery to the anterior IPDA. A postoperative computed tomography revealed no enhancement of the aneurysm and sufficient collateral blood supply by the patent bypass graft...
March 25, 2018: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29682115/selection-and-determination-of-treatment-for-the-spontaneous-isolated-dissection-of-the-superior-mesenteric-artery
#11
Zaiqiang Yu, Norihiro Kondo, Mari Chiyoya, Yasuyuki Suzuki, Ikuo Fukuda
Objective : This study aimed to clarify the selection and determination of appropriate treatment for acute symptomatic spontaneous isolated dissection of the superior mesenteric artery (SIDSMA). Methods : Data from 10 consecutive patients, who were diagnosed with symptomatic SIDSMA using computed tomography angiography and were managed in our hospital from January 2010 to October 2015, were retrospectively collected and analyzed. Results : There were nine males and one female; mean patient age was 50.3 (range, 35-64) years...
March 25, 2018: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29671149/biological-scoring-system-for-early-prediction-of-acute-bowel-ischemia-after-cardiac-surgery-the-palm-score
#12
Elie Zogheib, Cyril Cosse, Charles Sabbagh, Simon Marx, Thierry Caus, Marc Henry, Joseph Nader, Mathurin Fumery, Michael Bernasinski, Patricia Besserve, Faouzi Trojette, Cedric Renard, Pierre Duhaut, Said Kamel, Jean-Marc Regimbeau, Hervé Dupont
BACKGROUND: Bowel ischemia is a life-threatening emergency defined as an inadequate vascular perfusion leading to bowel inflammation resulting from impaired colonic/small bowel blood supply. Main issue for physicians regarding bowel ischemia diagnosis lies in the absence of informative and specific clinical or biological signs leading to delayed management, resulting in a poorer prognosis, especially after cardiac surgery. The aim of the present series was to propose a simple scoring system based on biological data for the diagnosis of bowel ischemia...
April 18, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29622397/the-route-and-timing-of-hydrogen-sulfide-therapy-critically-impacts-intestinal-recovery-following-ischemia-and-reperfusion-injury
#13
Amanda R Jensen, Natalie A Drucker, Jan P Te Winkel, Michael J Ferkowicz, Troy A Markel
PURPOSE: Hydrogen sulfide (H2 S) has many beneficial properties and may serve as a novel treatment in patients suffering from intestinal ischemia-reperfusion injury (I/R). The purpose of this study was to examine the method of delivery and timing of administration of H2 S for intestinal therapy during ischemic injury. We hypothesized that 1) route of administration of hydrogen sulfide would impact intestinal recovery following acute mesenteric ischemia and 2) preischemic H2 S conditioning using the optimal mode of administration as determined above would provide superior protection compared to postischemic application...
March 6, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29605020/targeting-intestinal-epithelial-cell-programmed-necrosis-alleviates-tissue-injury-after-intestinal-ischemia-reperfusion-in-rats
#14
Xiang Li, Yihong Ling, Zhongming Cao, Jiantong Shen, Shaoqian Chen, Weifeng Liu, Baolong Yuan, Shihong Wen
BACKGROUND: Intestinal dysfunction, especially acute pathologies linked to intestinal ischemia/reperfusion (I/R) injury, is profoundly affected by inflammation and improper execution of cell death. Few studies have examined the efficacy of combined strategies in regulated intestinal epithelial necrosis after intestinal I/R. Here, we evaluated the functional interaction between poly (adenosine diphosphate-ribose) polymerase 1 (PARP-1)-induced parthanatos and receptor-interacting protein 1/3 (RIP1/3) kinase-induced necroptosis in the pathophysiological course of acute ischemic intestinal injury...
May 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29600311/comparison-of-the-diagnostic-values-of-vascular-adhesion-protein-1-and-intestinal-fatty-acid-binding-protein-in-the-diagnosis-of-acute-mesenteric-ischemia
#15
Aynur Sahin, Damla Aydin Altay, Selim Demir, Esin Yulug, Ahmet Menteşe, Ozgur Tatli, Yunus Karaca, Senol Ardic, Abdulkadir Gunduz, Suleyman Turedi
OBJECTIVES: The aim of this study is to compare the diagnostic values of plasma levels of vascular adhesion protein-1 (VAP-1) and intestinal fatty acid-binding protein (I-FABP) for diagnosing acute mesenteric ischemia (AMI). METHODS: The study used a randomized, controlled experimental design. Forty-two female Sprague-Dawley rats were divided into three control groups and three ischemia groups. Plasma VAP-1 and I-FABP levels were measured, and the extent of ischemic damage was determined using a histopathological damage score in terminal ileum tissue samples...
March 29, 2018: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/29598863/presenting-systolic-blood-pressure-and-outcomes-in-patients-with-acute-aortic-dissection
#16
Eduardo Bossone, Riccardo Gorla, Troy M LaBounty, Toru Suzuki, Dan Gilon, Craig Strauss, Andrea Ballotta, Himanshu J Patel, Arturo Evangelista, Marek P Ehrlich, Stuart Hutchison, Eva Kline-Rogers, Daniel G Montgomery, Christoph A Nienaber, Eric M Isselbacher, Kim A Eagle
BACKGROUND: Presenting systolic blood pressure (SBP) is a powerful predictor of mortality in many cardiovascular settings, including acute coronary syndromes, cardiogenic shock, and acute heart failure. OBJECTIVES: This study evaluated the association of presenting SBP with in-hospital outcomes, specifically all-cause mortality, in acute aortic dissection (AAD). METHODS: The study included 6,238 consecutive patients (4,167 with type A and 2,071 with type B AAD) enrolled in the International Registry of Acute Aortic Dissection...
April 3, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29594895/clinical-implications-of-ct-findings-in-mesenteric-venous-thrombosis-at-admission
#17
S Salim, O Ekberg, J Elf, M Zarrouk, A Gottsäter, S Acosta
PURPOSE: The main aim of this study was to evaluate the association of computed tomography (CT) findings at admission and bowel resection rate in patients with mesenteric venous thrombosis (MVT). It was hypothesized that abnormal intestinal findings on CT were associated with a higher bowel resection rate. METHODS: Retrospective study of MVT patients treated between 2004 and 2017. CT images at admission and at follow-up were scrutinized according to a predefined protocol...
March 28, 2018: Emergency Radiology
https://www.readbyqxmd.com/read/29563335/endothelial-cell-pannexin1-modulates-severity-of-ischemic-stroke-by-regulating-cerebral-inflammation-and-myogenic-tone
#18
Miranda E Good, Stephanie A Eucker, Jun Li, Hannah M Bacon, Susan M Lang, Joshua T Butcher, Tyler J Johnson, Ronald P Gaykema, Manoj K Patel, Zhiyi Zuo, Brant E Isakson
Ischemic stroke is a leading cause of morbidity and mortality in the US; however, there currently exists only one effective acute pharmacological therapeutic intervention. Purinergic signaling has been shown to regulate vascular function and pathological processes, including inflammation and arterial myogenic reactivity, and plays a role in ischemic stroke outcome. Purinergic signaling requires extracellular purines; however, the mechanism of purine release from cells is unclear. Pannexin1 (Panx1) channels are potentially novel purine release channels expressed throughout the vascular tree that couples regulated purine release with purinergic signaling...
March 22, 2018: JCI Insight
https://www.readbyqxmd.com/read/29561390/risk-factors-for-acute-mesenteric-ischemia-in-critically-ill-burns-patients-a-matched-case-control-study
#19
Sabri Soussi, Marina Taccori, Christian De Tymowski, François Depret, Maïté Chaussard, Alexandre Fratani, Marion Jully, Alexandru Cupaciu, Axelle Ferry, Mourad Benyamina, Kevin Serror, David Boccara, Marc Chaouat, Maurice Mimoun, Pierre Cattan, Anne-Marie Zagdanski, James Anstey, Alexandre Mebazaa, Matthieu Legrand
OBJECTIVES: Burn-induced shock can lead to tissue hypoperfusion, including the gut. We performed this study to describe burn patients at risk of acute mesenteric ischemia (AMI) with the aim to identify potential modifiable risk factors. METHODS: Retrospective case-control study including adult severely burned patients between August 2012 and March 2017. Patients who developed AMI were matched to severely burned patients without AMI at a ratio of 1:3 (same year of admission, Abbreviated Burn Severity Index (ABSI) and Simplified Acute Physiology Score II (SAPSII))...
March 20, 2018: Shock
https://www.readbyqxmd.com/read/29556150/symptomatic-celiomesenteric-trunk-variable-presentations-and-outcomes-in-2-patients
#20
Michael L Kueht, Darrel L Wu, Joseph L Mills, Ramyar Gilani
Mesenteric ischemia can be difficult to diagnose without a high degree of suspicion because it presents in a variety of ways. Visceral vascular collaterals between the fore- and midgut often provide protection against ischemia; however, the presence of anatomic variations, such as celiomesenteric trunk, can undermine the expected redundancy. Misdiagnosis can result in prolonged suffering or death, as evidenced in 2 of our patients with celiomesenteric trunk. The first patient with chronic mesenteric ischemia was diagnosed in the clinic and underwent successful surgical correction; the other had overwhelming, acute mesenteric ischemia, which resulted in death...
February 2018: Texas Heart Institute Journal
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