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Yoshinori Kuboki, Qiming Jin, Masahiro Kikuchi, Javed Mamood, Hiroko Takita
This study aims to elucidate the feasible geometry of the scaffolds in bone and periodontal tissue engineering. Several biomaterials with different geometries are compared in terms of their patterns of ectopic BMP-induced chondrogenesis and osteogenesis. The materials include a honeycomb-shaped hydroxyapatite (HCHAP) with different tunnel sizes, a laser-perforated collagen membrane (LPM), and CPSA bioglass fibers. Implanted pellets were removed at 1-4 weeks and analyzed for bone and cartilage formation histologically and biochemically...
2002: Connective Tissue Research
Q M Jin, H Takita, T Kohgo, K Atsumi, H Itoh, Y Kuboki
Three different types of porous hydroxyapatite with pore sizes of 100-200 micrometer in diameter-porous particles of hydroxyapatite (PPHAP), porous blocks of hydroxyapatite (PBHAP), and honeycomb-shaped hydroxyapatite (HCHAP)-were compared in terms of their abilities to induce osteogenesis when implanted subcutaneously with recombinant human BMP-2 into rats and extracted at 1, 2, 3, and 4 weeks. Histologically, direct bone formation occurred in PPHAP and PBHAP while only endochondral ossification took place in HCHAP...
September 5, 2000: Journal of Biomedical Materials Research
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