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https://www.readbyqxmd.com/read/29245039/prenatal-arsenic-exposure-child-marriage-and-pregnancy-weight-gain-associations-with-preterm-birth-in-bangladesh
#1
Mohammad L Rahman, Molly L Kile, Ema G Rodrigues, Linda Valeri, Anita Raj, Maitreyi Mazumdar, Golam Mostofa, Quazi Quamruzzaman, Mahmudur Rahman, Russ Hauser, Andrea Baccarelli, Liming Liang, David C Christiani
BACKGROUND: Preterm birth is a disease of multifactorial etiologies that has environmental, social, and maternal health components. Individual studies have shown that exposure to arsenic contaminated drinking water, child marriage, and low maternal weight gain during pregnancy contribute to preterm birth. These factors are highly prevalent and often co-exist in Bangladesh, a country in South Asia with one of the world's highest prevalences of preterm birth. OBJECTIVE: To evaluate the individual and interactive effects of prenatal arsenic exposure, child marriage, and pregnancy weight gain on preterm birth in a prospective birth cohort in Bangladesh...
December 12, 2017: Environment International
https://www.readbyqxmd.com/read/29244163/regulation-of-chromosome-segregation-in-oocytes-and-the-cellular-basis-for-female-meiotic-errors
#2
Jessica Greaney, Zhe Wei, Hayden Homer
BACKGROUND: Meiotic chromosome segregation in human oocytes is notoriously error-prone, especially with ageing. Such errors markedly reduce the reproductive chances of increasing numbers of women embarking on pregnancy later in life. However, understanding the basis for these errors is hampered by limited access to human oocytes. OBJECTIVE AND RATIONALE: Important new discoveries have arisen from molecular analyses of human female recombination and aneuploidy along with high-resolution analyses of human oocyte maturation and mouse models...
December 13, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/29244078/patterns-of-plasma-glucagon-dynamics-do-not-match-metabolic-phenotypes-in-young-women
#3
Christina Gar, Marietta Rottenkolber, Vanessa Sacco, Sarah Moschko, Friederike Banning, Nina Hesse, Daniel Popp, Christoph Hübener, Jochen Seissler, Andreas Lechner
Context: The role of hyperglucagonemia in type 2 diabetes is still debated. Objective: We analyzed glucagon dynamics during oral glucose tolerance testing (oGTT) in young women with 1 out of 3 metabolic phenotypes: healthy control (normoglycemic after a normoglycemic pregnancy); normoglycemic high-risk (normoglycemic after a pregnancy complicated by gestational diabetes); and prediabetes/screening-diagnosed T2D. We asked if glucagon patterns were homogeneous within the metabolic phenotypes...
December 13, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29243838/evaluation-of-umbilical-vein-blood-volume-flow-in-preeclampsia-by-angle-independent-3d-sonography
#4
Stephen Z Pinter, Oliver D Kripfgans, Marjorie C Treadwell, Anna W Kneitel, J Brian Fowlkes, Jonathan M Rubin
OBJECTIVES: To investigate the association between umbilical vein blood volume flow and the condition of preeclampsia in an at-risk maternal patient cohort. Umbilical vein volume flow was quantified by a 3-dimensional (3D) sonographic technique that overcomes several limitations of standard sonographic flow measurement methods. METHODS: A total of 35 patients, each with a singleton pregnancy, were recruited to provide 5 patients with preeclampsia, derived as a subset from a 26-patient at-risk group, and 9 patients with normal pregnancies...
December 15, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29242181/a-data-model-for-teleconsultation-in-managing-high-risk-pregnancies-design-and-preliminary-evaluation
#5
Kolsoum Deldar, Fatemeh Tara, Kambiz Bahaadinbeigy, Mohammad Khajedaluee, Mahmood Tara
BACKGROUND: Teleconsultation is a guarantor for virtual supervision of clinical professors on clinical decisions made by medical residents in teaching hospitals. Type, format, volume, and quality of exchanged information have a great influence on the quality of remote clinical decisions or tele-decisions. Thus, it is necessary to develop a reliable and standard model for these clinical relationships. OBJECTIVE: The goal of this study was to design and evaluate a data model for teleconsultation in the management of high-risk pregnancies...
December 14, 2017: JMIR Medical Informatics
https://www.readbyqxmd.com/read/29241578/polymorphisms-in-the-leptin-rs7799039-gene-are-associated-with-an-increased-risk-of-excessive-gestational-weight-gain-but-not-with-leptin-concentration-during-pregnancy
#6
Maisa Cruz Martins, Janet Trujillo, Dayana Rodrigues Farias, Gilberto Kac
Single nucleotide polymorphisms (SNPs) in leptin (LEP) and leptin receptor (LEPR) have been shown to be linked to obesity-related metabolic markers and phenotype. Therefore, we hypothesized that the LEP-rs7799039 and LEPR-rs1137101 SNPs are related to the risk of pre-pregnancy overweight/obesity (body mass index ≥25 kg/m2) as well as to excessive gestational weight gain (GWG) and high concentrations of leptin throughout pregnancy. We investigated a prospective cohort of 147 Brazilian pregnant women through weeks 5-13, 20-26, and 30-36 of gestation...
November 2017: Nutrition Research
https://www.readbyqxmd.com/read/29241449/the-small-dense-ldl-particle-large-buoyant-ldl-particle-ratio-is-associated-with-glucose-metabolic-status-in-pregnancy
#7
Yanmin Chen, Mengkai Du, Jianyun Xu, Danqing Chen
BACKGROUND: The lipoprotein subfraction particle profile can be used to improve clinical assessments of cardiovascular disease risk and contribute to early detection of atherogenic dyslipidemia. Lipid alterations in gestational diabetes have been extensively studied, but the results have been inconsistent. Here, we investigated serum lipoprotein subfraction particle levels and their association with glucose metabolic status in pregnancy. METHODS: Twenty-eight pregnant women with gestational diabetes and 56 pregnant women with normal glucose tolerance matched for body mass index were enrolled in this study...
December 14, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29240902/dose-dependency-and-a-functional-cut-off-for-tpo-antibody-positivity-during-pregnancy
#8
Tim I M Korevaar, Victor J Pop, Layal Chaker, Mariette Goddijn, Yolanda B de Rijke, Peter H Bisschop, Maarten A Broeren, Vincent W V Jaddoe, Marco Medici, Theo J Visser, Eric A P Steegers, Tanja G Vrijkotte, Robin P Peeters
Objective: To investigate a dose-dependency of TPOAb concentrations in relation to thyroid function and premature delivery, and define a population-based, pregnancy-specific, functional cut-off for TPOAb positivity. Design: Individual participant meta-analysis of three prospective birth cohorts (Generation R, ABCD study and HAPPY study). Setting: Population-based studies in the Netherlands (2002-2014). Participants: 11 212 pregnant women (<20 weeks)...
December 12, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29238491/the-effect-of-training-interventions-on-the-psychological-factors-of-oral-health-in-pregnant-women
#9
Katayon Bakhtiar, Kasra Gharouni, Behnam Gharouni, Fereshteh Zamani Alavijeh, Mohammad Almasian, Maryam Bakhtiar, Fatemeh Bastami
Background and aim: Oral health is crucial for high-risk pregnant women in order to preserve their health and the health of their infants. Therefore, this study aimed to determine the impact of training programs on the behavior of pregnant mothers concerning oral health in Khorramabad, Iran. Methods: This is an educational experimental study carried out in 2015 on 164 pregnant women referring to health centers in the city of Khorramabad who were randomly divided into two groups (each n=82)...
October 2017: Electronic Physician
https://www.readbyqxmd.com/read/29236710/the-burden-of-obesity-in-women-of-reproductive-age-and-in-pregnancy-in-a-middle-income-setting-a-population-based-study-from-jamaica
#10
Lovney Kanguru, Affette McCaw-Binns, Jacqueline Bell, Novie Yonger-Coleman, Rainford Wilks, Julia Hussein
INTRODUCTION: Obesity is rising globally and is associated with increased risk of adverse pregnancy outcomes. This study aims to investigate overweight and obesity and its consequences among Jamaican women of reproductive age, particularly development of diabetes, hypertension and the risk of maternal death. MATERIALS AND METHODS: A national lifestyle survey (2007/8) of 1371 women of reproductive age provided data on the prevalence of high BMI, associated risk factors and co-morbidities...
2017: PloS One
https://www.readbyqxmd.com/read/29235559/body-size-modifies-the-relationship-between-maternal-serum-25-hydroxyvitamin-d-concentrations-and-gestational-diabetes-in-high-risk-women
#11
Anita J Valkama, Jelena M Meinilä, Saila B Koivusalo, Jaana Lindström, Kristiina Rönö, Aila E Tiitinen, Beata Stach-Lempinen, Hannu J Kautiainen, Heli Viljakainen, Sture Andersson, Johan G Eriksson
Obesity increases the risk of low 25-hydroxyvitamin D (25(OH)D) concentrations and gestational diabetes (GDM). We explored whether the association between GDM and change in 25(OH)D concentrations measured in the first (7-18 wk) and second (20-27 wk) trimesters of pregnancy is dependent on maternal BMI. The study was a prospective study of 219 women with BMI of ≥30 kg/m2, a history of GDM, or both. The participants were stratified by first-trimester BMI: BMI of <25.0, 25.0-29.9, 30.0-34.9, and ≥35 kg/m2...
November 6, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29235463/exposure-to-magnetic-field-non-ionizing-radiation-and-the-risk-of-miscarriage-a-prospective-cohort-study
#12
De-Kun Li, Hong Chen, Jeannette R Ferber, Roxana Odouli, Charles Quesenberry
Magnetic field (MF) non-ionizing radiation is widespread and everyone is exposed to some degree. This prospective cohort study of 913 pregnant women examined the association between high MF exposure and miscarriage risk. Cox (proportional hazards) regression was used to examine the association. After controlling for multiple other factors, women who were exposed to higher MF levels had 2.72 times the risk of miscarriage (hazard ratio = 2.72, 95% CI: 1.42-5.19) than those with lower MF exposure. The increased risk of miscarriage associated with high MF was consistently observed regardless of the sources of high MF...
December 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29235099/variations-from-morning-to-afternoon-of-middle-cerebral-and-umbilical-artery-blood-flow-and-fetal-heart-rate-variability-and-fetal-characteristics-in-the-normally-developing-fetus
#13
Tehila Avitan, Ari Sanders, Ursula Brain, Dan Rurak, Tim F Oberlander, Ken Lim
OBJECTIVE: To determine if there are changes in maternal uterine blood flow, fetal brain blood flow, fetal heart rate variability, and umbilical blood flow between morning (AM) and afternoon (PM) in healthy, uncomplicated pregnancies. STUDY DESIGN: In this prospective study, 68 uncomplicated singleton pregnancies (mean 35 + 0.7 weeks gestation) underwent a standard observational protocol at both 08:00 (AM) and 13:30 (PM) of the same day. This protocol included Doppler measurements of uterine, umbilical, and fetal middle cerebral artery (MCA) volume flow parameters (flow, HR, peak systolic velocity [PSV], PI, and RI) followed by computerized cardiotocography...
December 13, 2017: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/29234522/maternal-mental-health-and-child-problem-behaviours-disentangling-the-role-of-depression-and-borderline-personality-dysfunction
#14
Fay Huntley, Nicola Wright, Andrew Pickles, Helen Sharp, Jonathan Hill
Background: It is not known whether associations between child problem behaviours and maternal depression can be accounted for by comorbid borderline personality disorder (BPD) dysfunction. Aim: To examine the contributions of maternal depression and BPD symptoms to child problem behaviours. Method: Depression trajectories over the first-year postpartum were generated using repeated measurement from a general population sample of 997 mothers recruited in pregnancy...
November 2017: BJPsych Open
https://www.readbyqxmd.com/read/29233668/expression-of-hmgb1-in-maternal-exposure-to-fine-particulate-air-pollution-induces-lung-injury-in-rat-offspring-assessed-with-micro-ct
#15
Wenting Tang, Suran Huang, Lili Du, Wen Sun, Zhiqiang Yu, Yanmei Zhou, Jingsi Chen, Xiuying Li, Xiaomei Li, Bolan Yu, Dunjin Chen
OBJECTIVES: Maternal particulate matter with less than 2.5 μm in diameter (PM2.5) is associated with an increased risk for acute lower respiratory infections and allergic airway inflammation; however, its effect on the developing lung remains unclear. The aim of this study is to determine the effect of maternal PM2.5 during pregnancy on lung development in offspring. METHODS: Timed pregnant Sprague-Dawley rats were treated with PM2.5 (0.1, 0.5, 2.5, or 7.5 mg/kg) once every 3 days from day 0-18 of pregnancy and delivered at term...
December 9, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29233528/-overview-of-feelings-and-practices-of-gynecologists-and-obstetricians-for-the-noninvasive-prenatal-testing-in-france
#16
C Bardy-Evrard, A Mattuizzi, F Coatleven, A Nithart, G Evrard, A Benachi, I Nisand, L Sentilhes
OBJECTIVES: To evaluate the feelings and practices of French obstetrician-gynecologists in prescribing the noninvasive prenatal testing (NIPT) before the release of the French High Authority of Health recommendations. METHODS: Descriptive, declarative and transversal study, analyzing the feelings and practices of obstetrician-gynecologists, members of the French College of Gynecologists and Obstetricians (CNGOF) between February and May 2017 using an online questionnaire...
December 7, 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29233167/interventions-for-domestic-violence-among-pregnant-women-in-low-and-middle-income-countries-a-systematic-review-protocol
#17
Diksha Sapkota, Kathleen Baird, Amornrat Saito, Debra Anderson
BACKGROUND: Violence during pregnancy is a global problem, associated with serious health risks for both the mother and baby. Evaluation of interventions targeted for reducing or controlling domestic violence (DV) is still in its infancy, and the majority of findings are primarily from high-income countries (HICs). Therefore, there is an urgent need for generating evidence of DV interventions among pregnant women in low- and middle-income countries (LMICs). METHODS: Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines will be employed to structure the review...
December 12, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29233055/universal-screening-program-in-pregnant-women-and-newborns-at-risk-for-sickle-cell-disease-first-report-from-northern-italy
#18
Mariachiara Lodi, Elena Bigi, Giovanni Palazzi, Lara Vecchi, Riccardo Morandi, Monica Setti, Silvana Borsari, Giuliano Bergonzini, Lorenzo Iughetti, Donatella Venturelli
The implementation of screening programs for early detection of patients with sickle cell disease has become necessary in Italy as a result of the high rate of migration from areas with a high prevalence of the disease (Sub-Saharan Africa, Middle East and the Balkans). Following a pilot study performed in the province of Modena, Italy in 2011-2013, an official screening program was established on May 31 2014 for all pregnant women, free-of-charge for the family according to the National Guidelines for Physiological Pregnancy...
December 12, 2017: Hemoglobin
https://www.readbyqxmd.com/read/29230493/the-limitations-of-some-european-healthcare-databases-for-monitoring-the-effectiveness-of-pregnancy-prevention-programmes-as-risk-minimisation-measures
#19
R A Charlton, V Bettoli, H J Bos, A Engeland, E Garne, R Gini, A V Hansen, L T W de Jong-van den Berg, S Jordan, K Klungsøyr, A J Neville, A Pierini, A Puccini, M Sinclair, D Thayer, H Dolk
PURPOSE: Pregnancy prevention programmes (PPPs) exist for some medicines known to be highly teratogenic. It is increasingly recognised that the impact of these risk minimisation measures requires periodic evaluation. This study aimed to assess the extent to which some of the data needed to monitor the effectiveness of PPPs may be present in European healthcare databases. METHODS: An inventory was completed for databases contributing to EUROmediCAT capturing pregnancy and prescription data in Denmark, Norway, the Netherlands, Italy (Tuscany/Emilia Romagna), Wales and the rest of the UK, to determine the extent of data collected that could be used to evaluate the impact of PPPs...
December 11, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29229609/recent-advances-in-pre-exposure-prophylaxis-for-hiv
#20
REVIEW
Monica Desai, Nigel Field, Robert Grant, Sheena McCormack
Although pre-exposure prophylaxis (PrEP)-the use of antiretroviral drugs by non-infected people to prevent the acquisition of HIV-is a promising preventive option, important public health questions remain. Daily oral emtricitabine (FTC)-tenofovir disoproxil fumarate (TDF) is highly efficacious in preventing the acquisition of HIV in people at risk as a result of a range of different types of sexual exposure. There is good evidence of efficacy in women and men, and when men who have sex with men use event based dosing...
December 11, 2017: BMJ: British Medical Journal
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