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https://www.readbyqxmd.com/read/28822825/comparison-of-transforaminal-lumbar-interbody-fusion-outcomes-in-patients-receiving-rhbmp-2-versus-autograft
#1
Taleef R Khan, Kalin R Pearce, Steven J McAnany, Colleen M Peters, Munish C Gupta, Lukas P Zebala
BACKGROUND CONTEXT: Recombinant human bone morphogenetic protein 2 (rhBMP-2) plays a pivotal role in complex spine surgery. Despite its limited approval, the off-label use of rhBMP-2 is prevalent, particularly in transforaminal lumbar interbody fusions (TLIF) PURPOSE: To determine the effectiveness and safety of rhBMP-2 use in TLIF procedures versus autograft. STUDY DESIGN: Retrospective Cohort Study PATIENT SAMPLE: Patients older than 18 years undergoing spine surgery for lumbar degenerative spine disease at a single academic institution...
August 16, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28822528/management-of-obesity-in-adult-asian-indians
#2
REVIEW
S Behl, A Misra
The prevalence of obesity in India is increasing and ranges from 8% to 38% in rural and 13% to 50% in urban areas. Obesity is a risk factor for development of type 2 diabetes mellitus (T2DM), hypertension, dyslipidemia, coronary heart disease and many cancers. In Asian Indians excess abdominal and hepatic fat is associated with increased risk for T2DM and cardiovascular disease. There is higher risk for development of obesity related non-communicable diseases at lower body mass index levels, compared to white Caucasians...
July 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28821420/hyperglycemia-in-young-adults-seen-in-the-emergency-department-a-health-records-review
#3
Justin W Yan, Alexandra L Hamelin, Katherine M Gushulak, Kristine Van Aarsen, Melanie P Columbus, Ian G Stiell
Patients with diabetes who are in emerging adulthood, defined as the life stage between 18 and 29 years of age, have unique challenges in managing their illness and are at risk for acute complications and loss to follow up. This study's objective was to describe emergency department (ED) utilization because of hyperglycemia in emerging adults with diabetes and to characterize 30-day outcomes, including return visits and admission for hyperglycemia. This was a health-records review of emerging adults presenting over a 1-year period to 4 tertiary care EDs; the patients had known histories of diabetes and final diagnoses of hyperglycemia, diabetic ketoacidosis or hyperosmolar hyperglycemia...
August 15, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28821371/at-the-intersection-of-place-race-and-health-in-brazil-residential-segregation-and-cardio-metabolic-risk-factors-in-the-brazilian-longitudinal-study-of-adult-health-elsa-brasil
#4
Sharrelle Barber, Ana V Diez Roux, Letícia Cardoso, Simone Santos, Veronica Toste, Sherman James, Sandhi Barreto, Maria Schmidt, Luana Giatti, Dora Chor
Residential segregation is the spatial manifestation of entrenched socioeconomic and racial inequities and is considered a fundamental cause of racial inequalities in health. Despite the well-documented racialized spatial inequalities that exist in urban areas throughout Brazil, few empirical investigations have examined the link between residential segregation and health and considered its implications for racial health inequalities in this setting. In the present study, we used data from the Brazilian Longitudinal Study of Adult Health (2008-2010) to examine the association between economic residential segregation and two major cardio-metabolic risk factors-hypertension and diabetes...
May 27, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28821319/higher-dietary-acid-load-is-weakly-associated-with-higher-adiposity-measures-and-blood-pressure-in-japanese-adults-the-national-health-and-nutrition-survey
#5
Kentaro Murakami, M Barbara E Livingstone, Hitomi Okubo, Satoshi Sasaki
Epidemiologic evidence on the associations between dietary acid load and metabolic risk factors are limited and inconsistent. We investigated the hypothesis that dietary acid load is associated with adverse profiles of metabolic risk factors in Japanese adults. This cross-sectional study included 15 618 Japanese adults aged ≥20 years from the 2012 National Health and Nutrition Survey, Japan. Dietary acid load was characterized as potential renal acid load (PRAL) and net endogenous acid production (NEAP) based on information on nutrient intake, which was derived from a 1-day semi-weighed dietary record...
August 2017: Nutrition Research
https://www.readbyqxmd.com/read/28820783/epidemiology-of-obesity-in-the-hispanic-adult-population-in-the-united-states
#6
Kimberly Y Z Forrest, Marcy J Leeds, Alexander C Ufelle
Obesity is a major health concern in Hispanic populations. This study evaluated the epidemiology of obesity and associated factors among Hispanics using the data from the 2013-2014 National Health and Nutrition Examination Survey. Among the 1241 participants (20 years of age or older), the prevalence rates were as follows: overweight, 77.1%; obesity, 42.4%; and central obesity, 57.0%. These rates were consistent throughout most age groups. Significantly, more females than males were obese. Higher obesity rates were seen among those with diabetes, high cholesterol, hypertension, heart disease, and arthritis...
October 2017: Family & Community Health
https://www.readbyqxmd.com/read/28820316/cell-cycle-related-metabolism-and-mitochondrial-dynamics-in-a-replication-competent-pancreatic-beta-cell-line
#7
Chiara Montemurro, Suryakiran Vadrevu, Tatyana Gurlo, Alexandra E Butler, Kenny E Vongbunyong, Anton Petcherski, Orian S Shirihai, Leslie S Satin, Daniel Braas, Peter C Butler, Slavica Tudzarova
Cell replication is a fundamental attribute of growth and repair in multicellular organisms. Pancreatic beta-cells in adults rarely enter cell cycle, hindering the capacity for regeneration in diabetes. Efforts to drive beta-cells into cell cycle have so far largely focused on regulatory molecules such as cyclins and cyclin-dependent kinases (CDKs). Investigations in cancer biology have uncovered that adaptive changes in metabolism, the mitochondrial network, and cellular Ca(2+) are critical for permitting cells to progress through the cell cycle...
August 18, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28820061/renin-angiotensin-system-and-cytokines-in-chronic-kidney-disease-clinical-and-experimental-evidence
#8
Ariadna Andrade Saldanha Silva, Beranardo Bahia Finotti, Amanda Oliveira Lauar, Thiago Ruiz Rodrigues Prestes, Ana Cristina Simões E Silva
Chronic kidney disease (CKD) has become a major public health problem in Brazil and worldwide. There are many causes of CKD, being the congenital anomalies of the kidney and urinary tract and the glomerular diseases very common in pediatric patients, while diabetic nephropathy, CKD due to chronic arterial hypertension and glomerular diseases are predominant in adult patients. Many endogenous mediators have been related to the pathophysiology of CKD, being relevant the effects of the renin-angiotensin system (RAS) and the immune-inflammatory mediators including cytokines...
August 18, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/28819917/polyglandular-autoimmune-syndromes
#9
REVIEW
G J Kahaly, L Frommer
BACKGROUND: In recent years, scientific knowledge pertaining to the rare ORPHAN polyglandular autoimmune syndrome (registered code ORPHA 282196) has accumulated. OBJECTIVE: To offer current demographic, clinical, serological and immunogenic data on PAS. METHODS: Review of the pertinent and current literature. RESULTS: Polyglandular autoimmune syndromes (PAS) are multifactorial diseases with at least two coexisting autoimmune-mediated endocrinopathies...
August 17, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28818842/what-s-new-in-paediatric-hypertension
#10
REVIEW
Rowena Lalji, Kjell Tullus
Paediatric hypertension predisposes to hypertension and cardiovascular disease in adult life. Despite clear guidelines, there remains a lack of screening. Diagnosis remains challenging given the high rate of false-positive high blood pressure (BP) readings at a single visit; thus, multiple visits are required to confirm the diagnosis. Depending on the normative data sets used, hypertension in overweight and obese children can be underestimated by up to 20%. Specific BP targets are required for subgroups such as adolescents, children with chronic kidney disease (CKD) and type 1 diabetes...
August 17, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28818805/association-between-consumption-of-private-well-water-contaminated-by-low-levels-of-arsenic-and-dysglycemia-in-a-rural-region-of-quebec-canada
#11
Éric Lampron-Goulet, Fabien Gagnon, Marie-France Langlois
The association between arsenic (As) exposure and diabetes is not clearly defined for populations exposed to low or moderate levels of inorganic As (iAs) in drinking water (< 150µg/L). In the present study, the relationship between iAs concentration in drinking water (contaminated at a median level of 10.5µg/L) or As biomarkers (ie, urine and nails) and diabetes or prediabetes (defined as level of glycosylated hemoglobin - HbA1c - higher than 6%, self-reported diagnosis of diabetes by a physician, or the use of insulin or oral hypoglycemic drugs) was evaluated in 257 adults from Canada...
August 14, 2017: Environmental Research
https://www.readbyqxmd.com/read/28818533/the-association-between-bouted-and-non-bouted-physical-activity-on-retinopathy-prevalence
#12
Emily Frith, Paul D Loprinzi
OBJECTIVE: We evaluated the specific differential association between non-bouted, lifestyle physical activities (vs. structured exercise; i.e., bouted physical activity) on retinopathy prevalence among a national sample of the broader U.S. adult population. METHODS: Data from the 2005-2006 National Health and Nutrition Examination Survey (NHANES) was used to identify 1501 adults, between 40 and 85years. Bouted and non-bouted physical activities were assessed using objective accelerometer monitoring...
August 14, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28818343/high-dietary-phosphorus-intake-is-associated-with-an-increased-risk-of-type-2-diabetes-in-the-large-prospective-e3n-cohort-study
#13
Francesca Romana Mancini, Aurélie Affret, Courtney Dow, Beverley Balkau, Françoise Clavel-Chapelon, Fabrice Bonnet, Marie-Christine Boutron-Ruault, Guy Fagherazzi
Phosphorus is an essential nutrient; the adult recommended daily intake ranges from 550 to 700 mg/day, with a tolerated upper limit of 4000 mg/day. Phosphorus intake has increased in the general population in recent years, and simultaneously an alarming rise of type 2 diabetes incidences has been observed. No study has investigated the relationship between phosphorus intake and the risk of type 2 diabetes. To evaluate the association between phosphorus intake and incidence of type 2 diabetes. Among 71,270 women from the French E3N-EPIC cohort, 1845 cases of incident type 2 diabetes were validated during follow-up (1993-2011)...
August 5, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28818246/cancer-prevention-during-early-adulthood-highlights-from-a-meeting-of-experts
#14
Dawn M Holman, Mary C White, Meredith L Shoemaker, Greta M Massetti, Mary C Puckett, Claire D Brindis
Using a life course approach, the Centers for Disease Control and Prevention's Division of Cancer Prevention and Control and the National Association of Chronic Disease Directors co-hosted a 2-day meeting with 15 multidisciplinary experts to consider evidence linking factors in early adulthood to subsequent cancer risk and strategies for putting that evidence into practice to reduce cancer incidence. This paper provides an overview of key themes from those meeting discussions, drawing attention to the influence that early adulthood can have on lifetime cancer risk and potential strategies for intervention during this phase of life...
September 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28818243/mental-health-problems-and-cancer-risk-factors-among-young-adults
#15
Greta M Massetti, Cheryll C Thomas, Jessica King, Kathleen Ragan, Natasha Buchanan Lunsford
INTRODUCTION: Chronic mental health problems often emerge in young adulthood, when adults begin to develop lifelong health behaviors and access preventive health services. The associations between mental health problems and modifiable cancer risk factors in young adulthood are not well understood. METHODS: In 2016, the authors analyzed 2014 Behavioral Risk Factor Surveillance System data on demographic characteristics, health service access and use, health status, and cancer risk factors (tobacco use, alcohol use, overweight or obesity, physical activity, and sleep) for 90,821 young adults aged 18-39 years with mental health problems (depressive disorder or frequent mental distress) compared to other young adults...
September 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28818240/reducing-cancer-and-cancer-disparities-lessons-from-a-youth-generated-diabetes-prevention-campaign
#16
Dean Schillinger, Pamela M Ling, Sarah Fine, Cherrie B Boyer, Elizabeth Rogers, Roberto Ariel Vargas, Kirsten Bibbins-Domingo, Wen-Ying Sylvia Chou
Adolescence and young adulthood, a period essential for determining exposures over the life-course, is an ideal time to intervene to lower cancer risk. This demographic group can be viewed as both the target audience and generator of messages for cancer prevention, such as skin cancer, obesity-, tobacco-, and human papillomavirus-related cancers. The purpose of this paper is to encourage innovative health communications that target youth; youth behavior; and the structural, environmental, and social determinants of youth behavior as critical areas of focus for cancer prevention and disparities reduction...
September 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28818160/determination-of-mean-glycated-haemoglobin-in-healthy-adults-of-a-local-population
#17
Sumbal Nida, Dilshad Ahmed Khan, Aamir Ijaz, Muhammad Qaiser Alam Khan, Hira Aleef, Maria Abbasi
OBJECTIVE: To determine the mean hemoglobin HbA1C levels of disease-free adults in a local population and its optimum cutoff for the diagnosis of diabetes. STUDY DESIGN: Cross-sectional study. PLACE AND DURATION OF STUDY: Department of Chemical Pathology and Endocrinology, Armed Forces Institute of Pathology, Rawalpindi, from January to September 2015. METHODOLOGY: Healthy subjects aged 18 years and above of either gender were recruited from local population...
July 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28817862/practice-guidelines-for-hypertension
#18
David Zeigler, Anish Patel, Candace Zeigler
Hypertension is very prevalent in South Dakota affecting approximately one-third of the adult population. Management and treatment of the disease has recently been the subject of considerable debate centered on what should be the blood pressure goal depending on the patient's age and co-morbid conditions. Recently, a randomized trial of intensive versus standard blood pressure control indicated that a systolic blood pressure of less than 120 mmHg in patients at high risk for cardiovascular events but without diabetes, resulted in significantly lower rates of non-fatal major cardiovascular events and death from any cause...
2017: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/28817829/altered-expression-profile-of-circular-rnas-in-the-serum-of-patients-with-diabetic-retinopathy-revealed-by-microarray
#19
Yonghao Gu, Genjie Ke, Lin Wang, Enliang Zhou, Kai Zhu, Yingying Wei
PURPOSE: Diabetic retinopathy (DR) is the leading cause of blindness among working age adults. Circular RNAs (circRNAs) are a kind of noncoding RNAs that are involved in the development of some diseases. Here, we aimed to determine the possible role of circRNAs in the pathogenesis of DR by determining the expression profile of circRNAs in the serum of DR patients. METHODS: Nineteen subjects with type 2 diabetes mellitus with proliferative DR (T2DR), 15 subjects with type 2 diabetes mellitus without DR (T2DM), and 21 age-matched nondiabetic control subjects were included in the study...
August 18, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/28817790/maximum-lifetime-body-mass-index-and-mortality-in-mexican-american-adults-the-national-health-and-nutrition-examination-survey-iii-1988-1994-and-nhanes-1999-2010
#20
Carrie R Howell, Kevin Fontaine, Keisuke Ejima, Kirsten K Ness, Andrea Cherrington, Tapan Mehta
INTRODUCTION: Studies in US Hispanic adults indicate no deleterious association between obesity and death. We tested the hypothesis that accounting for weight history would provide more insight into this nonassociation. METHODS: We used the National Health and Nutrition Examination Survey (NHANES) to examine associations between maximum lifetime body mass index (BMI) and all-cause and cause-specific mortality among US-residing Mexican American adults. BMI was classified as underweight (<18...
August 17, 2017: Preventing Chronic Disease
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