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JOURNAL ARTICLE
Zoila I Alvarez-Aponte, Alekhya M Govindaraju, Zachary F Hallberg, Alexa M Nicolas, Myka A Green, Kenny C Mok, Citlali Fonseca-Garcia, Devin Coleman-Derr, Eoin L Brodie, Hans K Carlson, Michiko E Taga
Soil microbial communities impact carbon sequestration and release, biogeochemical cycling, and agricultural yields. These global effects rely on metabolic interactions that modulate community composition and function. However, the physicochemical and taxonomic complexity of soil and the scarcity of available isolates for phenotypic testing are significant barriers to studying soil microbial interactions. Corrinoids-the vitamin B12 family of cofactors-are critical for microbial metabolism, yet they are synthesized by only a subset of microbiome members...
April 22, 2024: ISME Journal
#2
JOURNAL ARTICLE
Edith Chen, Tianyi Yu, Katherine B Ehrlich, Phoebe H Lam, Tao Jiang, Thomas W McDade, Gregory E Miller, Gene H Brody
IMPORTANCE: Upward mobility (via educational attainment) is highly valued, but longitudinal associations with mental and physical health among Black youths are less understood. OBJECTIVE: To examine associations of childhood family disadvantage and college graduation with adult mental and physical health in Black youths followed up into adulthood. DESIGN, SETTING, AND PARTICIPANTS: This longitudinal, prospective cohort study of Black youths from the state of Georgia who were studied for 20 years (ages 11 to 31 years) was conducted between 2001 and 2022...
March 4, 2024: JAMA Network Open
#3
JOURNAL ARTICLE
Andrew P Michelson, Patrick G Lyons, Nguyet M Nguyen, Daniel Reynolds, Rachel McDonald, Colleen A McEvoy, Vladimir Despotovic, Steven L Brody, Marin H Kollef, Bryan D Kraft
BACKGROUND: The clinical benefit of using inhaled epoprostenol (iEpo) through a humidified high-flow nasal cannula (HHFNC) remains unknown for patients with COVID-19. RESEARCH QUESTION: Can iEpo prevent respiratory deterioration for patients with positive SARS-CoV-2 findings receiving HHFNC? STUDY DESIGN AND METHODS: This multicenter retrospective cohort analysis included patients aged 18 years or older with COVID-19 pneumonia who required HHFNC treatment...
December 2023: CHEST Crit Care
#4
JOURNAL ARTICLE
Shannon M Fernando, Daniel Brodie, Ryan P Barbaro, Cara Agerstrand, Jenelle Badulak, Errol L Bush, Thomas Mueller, Laveena Munshi, Eddy Fan, Graeme MacLaren, Daniel I McIsaac
PURPOSE: Venovenous extracorporeal membrane oxygenation (VV-ECMO) can be used to support patients with refractory acute respiratory failure, though guidance on patient selection is lacking. While age is commonly utilized as a factor in establishing the potential VV-ECMO candidacy of these patients, little is known regarding its association with outcome. We studied the association between increasing patient age and outcomes among patients with acute respiratory failure receiving VV-ECMO...
February 20, 2024: Intensive Care Medicine
#5
JOURNAL ARTICLE
L Micenková, K Brodı Ková, S Smetanová, J Bosák, D Šmajs, P Andrla, E Budinská
Probiotic supplementation in childhood serves as an additional source of bacterial colonisers and represents an opportunity to beneficially manipulate the intestinal microbiome. Differences in the ability of probiotic strains to colonise the gut may be related to the variously diversified gut microbiome. We report the results of the association between composition of the gut microbiome and the colonisation capacity of the probiotic strain Escherichia coli A0 34/86 (CNB - Colinfant New Born supplement) in the cases of three healthy children in different development stages (infant, toddler, and pre-school), as a preliminary insight to possible future prospective studies of this subject...
January 23, 2024: Beneficial Microbes
#6
JOURNAL ARTICLE
Taylor Combs, Brody Nelson, Maciej Jakucki, Johannes Schneppendahl, Devon Moody, Robert A Kaufmann
PURPOSE: The goal of this study was to develop a dynamic elbow testing apparatus that reproduces active joint motion at different shoulder positions to quantify the capabilities of total elbow arthroplasty designs. METHODS: We designed a testing apparatus to create active cyclic elbow joint motion in human cadaveric and sawbones composite upper extremities. Two pneumatic actuators recreated humerus-originating muscles while rubber bands simulated forearm muscle action...
January 2024: Journal of hand surgery global online
#7
JOURNAL ARTICLE
Meris Esra Bozkurt, Tugba Erdogan, Nezahat Muge Catikkas, Serdar Ozkok, Cihan Kilic, Gulistan Bahat, Mehmet Akif Karan
OBJECTIVE: The prevalence of obesity by fat percentage has seen a steady increase in older adults in recent years, secondary to increases in fat mass in body composition, even in healthy aging. Malnutrition is a common geriatric syndrome with serious clinical outcomes. Increases in fat mass and waist circumference with healthy aging should not prevent the risk of malnutrition from being masked. Malnutrition is often ignored in obese older people due to low BMI cut-off values in many screening tests...
January 23, 2024: Aging Clinical and Experimental Research
#8
JOURNAL ARTICLE
Zhengzi Yi, Caixia Xi, Madhav C Menon, Paolo Cravedi, Fasika Tedla, Alan Soto, Zeguo Sun, Keyu Liu, Jason Zhang, Chengguo Wei, Man Chen, Wenlin Wang, Brandon Veremis, Monica Garcia-Barros, Abhishek Kumar, Danielle Haakinson, Rachel Brody, Evren U Azeloglu, Lorenzo Gallon, Philip O'Connell, Maarten Naesens, Ron Shapiro, Robert B Colvin, Stephen Ward, Fadi Salem, Weijia Zhang
Lesion scores on procurement donor biopsies are commonly used to guide organ utilization for deceased-donor kidneys. However, frozen sections present challenges for histological scoring, leading to inter- and intra-observer variability and inappropriate discard. Therefore, we constructed deep-learning based models to recognize kidney tissue compartments in hematoxylin &eosin-stained sections from procurement needle biopsies performed nationwide in years 2011-2020. To do this, we extracted whole-slide abnormality features from 2431 kidneys and correlated with pathologists' scores and transplant outcomes...
November 3, 2023: Kidney International
#9
JOURNAL ARTICLE
Shannon M Fernando, Graeme MacLaren, Ryan P Barbaro, Rebecca Mathew, Laveena Munshi, Purnema Madahar, Justin A Fried, Kollengode Ramanathan, Roberto Lorusso, Daniel Brodie, Daniel I McIsaac
PURPOSE: Venoarterial extracorporeal membrane oxygenation (V-A ECMO) can be used to support severely ill patients with cardiogenic shock. While age is commonly used in patient selection, little is known regarding its association with outcomes in this population. We sought to evaluate the association between increasing age and outcomes following V-A ECMO. METHODS: We used individual-level patient data from 440 centers in the international Extracorporeal Life Support Organization registry...
October 4, 2023: Intensive Care Medicine
#10
JOURNAL ARTICLE
Adam Greene, Pierre-Marc Dion, Brodie Nolan, Rob Trachter, Erik Vu, Jan Trojanowski
BACKGROUND: For critically ill and injured patients, timely access to definitive care is associated with a reduction in avoidable mortality. Access to definitive care is significantly affected by geographic remoteness. To overcome this disparity, a robust critical care transport (CCT) or retrieval system is essential to support the equity of care and overcome the tyranny of distance. While critical care transport or retrieval systems have evolved over the years, there is no universally accepted system or standard, which has led to considerable variation in practices...
October 3, 2023: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
#11
JOURNAL ARTICLE
Matthew D Galsky, Siamak Daneshmand, Sudeh Izadmehr, Edgar Gonzalez-Kozlova, Kevin G Chan, Sara Lewis, Bassam El Achkar, Tanya B Dorff, Jeremy Paul Cetnar, Brock O Neil, Anishka D'Souza, Ronac Mamtani, Christos Kyriakopoulos, Tomi Jun, Mahalya Gogerly-Moragoda, Rachel Brody, Hui Xie, Kai Nie, Geoffrey Kelly, Amir Horwitz, Yayoi Kinoshita, Ethan Ellis, Yohei Nose, Giorgio Ioannou, Rafael Cabal, G Kenneth Haines, Li Wang, Kent W Mouw, Robert M Samstein, Reza Mehrazin, Nina Bhardwaj, Menggang Yu, Qianqian Zhao, Seunghee Kim-Schulze, Robert Sebra, Jun Zhu, Sacha Gnjatic, John Sfakianos, Sumanta K Pal
Cystectomy is a standard treatment for muscle-invasive bladder cancer (MIBC), but it is life-altering. We initiated a phase 2 study in which patients with MIBC received four cycles of gemcitabine, cisplatin, plus nivolumab followed by clinical restaging. Patients achieving a clinical complete response (cCR) could proceed without cystectomy. The co-primary objectives were to assess the cCR rate and the positive predictive value of cCR for a composite outcome: 2-year metastasis-free survival in patients forgoing immediate cystectomy or <ypT1N0 in patients electing immediate cystectomy...
October 2, 2023: Nature Medicine
#12
JOURNAL ARTICLE
Jorik Simons, Michele Di Mauro, Silvia Mariani, Justine Ravaux, Iwan C C van der Horst, Rob G H Driessen, Jan Willem Sels, Thijs Delnoij, Daniel Brodie, Darryl Abrams, Thomas Mueller, Fabio Silvio Taccone, Mirko Belliato, Mike Lars Broman, Maximilian V Malfertheiner, Udo Boeken, John Fraser, Dominik Wiedemann, Jan Belohlavek, Nicholas A Barrett, Joseph E Tonna, Federico Pappalardo, Ryan P Barbaro, Kollengode Ramanathan, Graeme MacLaren, Walther N K A van Mook, Barend Mees, Roberto Lorusso
OBJECTIVES: Peripheral venoarterial extracorporeal membrane oxygenation (ECMO) with femoral access is obtained through unilateral or bilateral groin cannulation. Whether one cannulation strategy is associated with a lower risk for limb ischemia remains unknown. We aim to assess if one strategy is preferable. DESIGN: A retrospective cohort study based on the Extracorporeal Life Support Organization registry. SETTING: ECMO centers worldwide included in the Extracorporeal Life Support Organization registry...
September 6, 2023: Critical Care Medicine
#13
JOURNAL ARTICLE
Leanne A Melbourne, Juliet Brodie, Emily J Rayfield, Danna Titelboim, Oliver T Lord, Daniela N Schmidt
Coralline algae form complex habitats which are biodiversity hotspots. Experimental studies suggest that climate change will decrease coralline algal structural integrity. These experiments, however, lack information on local morphological variability and how much structural change would be needed to threaten habitat formation. Here, using finite element modelling, we assess variability in cellular structure and chemical composition of the carbonate skeleton of four coralline algal species from Britain in contemporary and historical specimens collected over the last 130 years...
August 18, 2023: Scientific Reports
#14
Soo Heon Kwak, Ryan B Hernandez-Cancela, Daniel A DiCorpo, David E Condon, Jordi Merino, Peitao Wu, Jennifer A Brody, Jie Yao, Xiuqing Guo, Fariba Ahmadizar, Mariah Meyer, Murat Sincan, Josep M Mercader, Sujin Lee, Jeffrey Haessler, Ha My T Vy, Zhaotong Lin, Nicole D Armstrong, Shaopeng Gu, Noah L Tsao, Leslie A Lange, Ningyuan Wang, Kerri L Wiggins, Stella Trompet, Simin Liu, Ruth J F Loos, Renae Judy, Philip H Schroeder, Natalie R Hasbani, Maxime M Bos, Alanna C Morrison, Rebecca D Jackson, Alexander P Reiner, JoAnn E Manson, Ninad S Chaudhary, Lynn K Carmichael, Yii-Der Ida Chen, Kent D Taylor, Mohsen Ghanbari, Joyce van Meurs, Achilleas N Pitsillides, Bruce M Psaty, Raymond Noordam, Ron Do, Kyong Soo Park, J Wouter Jukema, Maryam Kavousi, Adolfo Correa, Stephen S Rich, Scott M Damrauer, Catherine Hajek, Nam H Cho, Marguerite R Irvin, James S Pankow, Girish N Nadkarni, Robert Sladek, Mark O Goodarzi, Jose C Florez, Daniel I Chasman, Susan R Heckbert, Charles Kooperberg, Josée Dupuis, Rajeev Malhotra, Paul S de Vries, Ching-Ti Liu, Jerome I Rotter, James B Meigs
BACKGROUND: Type 2 diabetes mellitus (T2D) confers a two- to three-fold increased risk of cardiovascular disease (CVD). However, the mechanisms underlying increased CVD risk among people with T2D are only partially understood. We hypothesized that a genetic association study among people with T2D at risk for developing incident cardiovascular complications could provide insights into molecular genetic aspects underlying CVD. METHODS: From 16 studies of the Cohorts for Heart & Aging Research in Genomic Epidemiology (CHARGE) Consortium, we conducted a multi-ancestry time-to-event genome-wide association study (GWAS) for incident CVD among people with T2D using Cox proportional hazards models...
July 28, 2023: medRxiv
#15
JOURNAL ARTICLE
Eric D Kirby, Christina B Jones, Shaun D Fickling, Gabriela Pawlowski, Sonia M Brodie, Lara A Boyd, Jan Venter, Nicholas Moser, Sukhvinder Kalsi-Ryan, George Medvedev, Ryan C N D'Arcy
BACKGROUND: Non-invasive neuromodulation using translingual neurostimulation (TLNS) has been shown to advance rehabilitation outcomes, particularly when paired with physical therapy (PT). Together with motor gains, patient-reported observations of incidental improvements in cognitive function have been noted. Both studies in healthy individuals and case reports in clinical populations have linked TLNS to improvements in attention-related cognitive processes. We investigated if the use of combined TLNS/PT would translate to changes in objective neurophysiological cognitive measures in a real-world clinical sample of patients from two separate rehabilitation clinics...
2023: Frontiers in Human Neuroscience
#16
JOURNAL ARTICLE
Paul D S Brown, Nicole Ketter, Mathew Vis-Dunbar, Brodie M Sakakibara
BACKGROUND: Emblica officinalis (EO) fruit consumption has been found to have a beneficial effect on cardiovascular disease (CVD) physiological risk factors in preliminary clinical intervention trials; however, questions remain regarding the overall effectiveness of EO on CVD risk. The purpose of this systematic review and meta-analysis is to: 1) systematically describe the clinical research examining EO; and 2) quantitatively assess the effects of EO on CVD physiological risk factors...
June 9, 2023: BMC complementary medicine and therapies
#17
JOURNAL ARTICLE
Katherine B Ehrlich, Sarah M Lyle, Kelsey L Corallo, Julie M Brisson, Elizabeth R Wiggins, Tianyi Yu, Edith Chen, Gregory E Miller, Gene H Brody
BACKGROUND: Low socioeconomic status (SES) is a risk factor for poor outcomes across development. Recent evidence suggests that, although psychosocial resilience among youth living in low-SES households is common, such expressions of resilience may not extend to physical health. Questions remain about when these diverging mental and physical health trajectories emerge. The current study hypothesized that skin-deep resilience - a pattern wherein socioeconomic disadvantage is linked to better mental health but worse physical health for individuals with John Henryism high-effort coping - is already present in childhood...
March 2024: Journal of Child Psychology and Psychiatry, and Allied Disciplines
#18
JOURNAL ARTICLE
Ahmed A Rabie, Alyaa Elhazmi, Mohamed H Azzam, Akram Abdelbary, Ahmed Labib, Alain Combes, Bishoy Zakhary, Graeme MacLaren, Ryan P Barbaro, Giles J Peek, Marta Velia Antonini, Kiran Shekar, Abdulrahman Al-Fares, Pranay Oza, Yatin Mehta, Huda Alfoudri, Kollengode Ramanathan, Mark Ogino, Lakshmi Raman, Matthew Paden, Daniel Brodie, Robert Bartlett
BACKGROUND: The high-quality evidence on managing COVID-19 patients requiring extracorporeal membrane oxygenation (ECMO) support is insufficient. Furthermore, there is little consensus on allocating ECMO resources when scarce. The paucity of evidence and the need for guidance on controversial topics required an international expert consensus statement to understand the role of ECMO in COVID-19 better. Twenty-two international ECMO experts worldwide work together to interpret the most recent findings of the evolving published research, statement formulation, and voting to achieve consensus...
May 2, 2023: Annals of Intensive Care
#19
JOURNAL ARTICLE
Edith Chen, Tianyi Yu, Gene H Brody, Phoebe H Lam, Bridget J Goosby, Gregory E Miller
BACKGROUND: This study examined how experiences with discrimination relate to inflammation, a key biological pathway in mental and physical illnesses, and whether associations are moderated by gender across two samples of adolescents of color. METHODS: Study 1 was a longitudinal study of 419 African American adolescents assessed on discrimination (ages 19-20), with trajectories of biomarkers of low-grade inflammation (C-reactive protein and soluble urokinase plasminogen activator receptor) measured from ages 25 to 29...
April 2023: Biol Psychiatry Glob Open Sci
#20
JOURNAL ARTICLE
D Alex Crowder, Vladimir Sarpe, Bruno C Amaral, Nicholas I Brodie, Andrew R M Michael, David C Schriemer
Crosslinking mass spectrometry (XL-MS) is a valuable technique for generating point-to-point distance measurements in protein space. However, cell-based XL-MS experiments require efficient software that can detect crosslinked peptides with sensitivity and controlled error rates. Many algorithms implement a filtering strategy designed to reduce the size of the database prior to mounting a search for crosslinks, but concern has been expressed over the possibility of reduced sensitivity using these strategies...
April 6, 2023: Analytical Chemistry
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