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lipidic emulsion

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https://www.readbyqxmd.com/read/28322967/regulating-dyslipidemia-effect-of-polysaccharides-from-pleurotus-ostreatus-on-fat-emulsion-induced-hyperlipidemia-rats
#1
Yan Zhang, Zhuowei Wang, Gang Jin, Xiudong Yang, Hongli Zhou
This study was conducted to evaluate the regulating dyslipidemia effect of polysaccharides from Pleurotus ostreatus (POP) on fat-emulsion-induced hyperlipidemia rats. A plasma metabonomics method based on ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry was applied to analyze the holistic mechanism of POP in a hyperlipidemia rat model. Multivariate statistical approaches such as principal component analysis and orthogonal projection to latent structure square-discriminant analysis revealed distinctions among the control, hyperlipidemia model, and POP groups...
March 16, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28315731/evaluation-of-the-drug-loading-capacity-of-different-lipid-nanoparticle-dispersions-by-passive-drug-loading
#2
Karin M Rosenblatt, Heike Bunjes
When using lipid nanoparticles as drug carrier system it is important to know how much drug can be loaded to the nanoparticles. The mainly used drug loading procedure is an empirical approach dissolving the drug in the liquid lipid during preparation of the nanoparticles. This approach does not necessarily lead to the truly loadable amount, as the lipid can, e.g. be overloaded, in particular when it is processed in the heat. In this work, a different procedure, passive drug loading, was evaluated to determine the drug loading capacity of various lipid nanoparticles (supercooled trimyristin emulsion droplets, solid trimyristin nanoparticles, tristearin nanoparticles in the α-modification and cholesteryl myristate nanoparticles in the supercooled smectic as well as in the crystalline state)...
March 15, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28315084/multiple-lipid-nanoparticles-mln-a-new-generation-of-lipid-nanoparticles-for-drug-delivery-systems-lamivudine-mln-experimental-design
#3
Suellen M T Cavalcanti, Cláudia Nunes, Sofia A C Lima, José L Soares-Sobrinho, Salette Reis
PURPOSE: An optimized methodology for the development of a new generation of lipid nanoparticles, the multiple lipid nanoparticles (MLN) is described. MLN have characteristics between nanostructured lipid carriers (NLC) and multiple emulsions (W/O/W), but without the outer aqueous phase. METHODS: The production is based on a hot homogenization method combined with high shear and ultrasonication. The antiretroviral agent lamivudine (3TC), was loaded in the MLN. For comparison purposes, NLC-3TC formulation was also developed and physico-chemically characterized by the same parameters as MLN-3TC...
March 17, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28304022/altering-the-level-of-calcium-changes-the-physical-properties-and-digestibility-of-casein-based-emulsion-gels
#4
Irene McIntyre, Michael O Sullivan, Dolores O Riordan
Casein-based emulsion gels prepared with different types of lipid (i.e. milk fat or rapeseed oil) were formulated with high (774 mg Ca per 100 g) or low (357 mg Ca per 100 g) calcium levels by blending acid and rennet casein. Their physicochemical characteristics (i.e. composition, texture, microstructure & water mobility) and in vitro digestibility were compared to conventionally formulated high-calcium (723 mg Ca per 100 g) emulsion gels made from rennet casein with calcium chelating salts (CCS). CCS-free, high-calcium emulsion gels were significantly (p ≤ 0...
March 17, 2017: Food & Function
https://www.readbyqxmd.com/read/28302212/-effects-of-%C3%AF-3-polyunsaturated-fatty-acids-on-lymphocyte-apoptosis-rate-in-rats-with-sepsis
#5
Hong-Jun Miao, Dan Wang, Xu-Hua Ge, Xiao-Nan Li
OBJECTIVE: To investigate the effects of ω-3 polyunsaturated fatty acids (ω-3 PUFAs) on the apoptosis of thymic and splenic lymphocytes in rats with sepsis. METHODS: A total of 80 female Sprague-Dawley rats aged 7-8 weeks were randomly divided into model group, conventional lipid emulsion group (0.1 g/kg daily), low-dose ω-3 PUFAs group (0.1 g/kg daily), middle-dose ω-3 PUFAs group (0.2 g/kg daily), and high-dose ω-3 PUFAs group (0.3 g/kg daily). Cecal ligation and puncture were used to establish a rat model of sepsis...
March 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28299707/functionalized-vesicles-by-microfluidic-device
#6
Derek Vallejo, Shih-Hui Lee, Abraham Lee
In recent years, lipid vesicles have become popular vehicles for the creation of biosensors. Vesicles can hold reaction components within a selective permeable membrane that provides an ideal environment for membrane protein biosensing elements. The lipid bilayer allows a protein to retain its native structure and function, and the membrane fluidity can allow for conformational changes and physiological interactions with target analytes. Here, we present two methods for the production of giant unilamellar vesicles (GUVs) within a microfluidic device that can be used as the basis for a biosensor...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28298542/lipid-emulsion-added-to-a-liquid-high-carbohydrate-diet-and-voluntary-running-exercise-reduce-lipogenesis-and-ameliorate-early-stage-hepatic-steatosis-in-mice
#7
Kuan-Hsun Huang, Lei Hao, Philip B Smith, Connie J Rogers, Andrew D Patterson, A Catharine Ross
Background: The use of parenteral nutrition formulas is often associated with the development of hepatic steatosis. We have shown previously that the addition of a lipid emulsion (LE) rich in n-6 (ω-6) fatty acids (FAs) ameliorated triglyceride (TG) accumulation in the livers of nonobese mice fed a high-carbohydrate diet (HCD) for 5 wk. However, it remains unclear how rapidly this condition develops and whether it can be prevented by LE with or without a running wheel for voluntary exercise (Exe).Objective: We investigated in an 8-d study whether mice develop steatosis and whether the administration of LE with or without Exe reduces the concentration of total FAs and prevents an increase in the expression of genes in the liver associated with lipogenesis...
March 15, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28298173/effects-of-two-different-lipid-emulsions-on-morbidities-and-oxidant-stress-statuses-in-preterm-infants-an-observational-study
#8
Sezin Unal, Nihal Demirel, Sara Erol, Dilek Ulubas Isik, Ferit Kulali, Fatma Iyigun, Ahmet Yagmur Bas
OBJECTIVE: We examined the morbidities and oxidative stress statuses in preterms receiving either SMOFlipid or ClinOleic. STUDY DESIGN: This observational study was performed in Etlik Zubeyde Hanim Hospital, Turkey. Infants received SMOFlipid (5 months) or ClinOleic (7 months). Two hundred and twenty seven infants (SMOFlipid: 93, ClinOleic: 134) very low birth weighted infants were included. The oxidative stress status was evaluated in infants at low risk of oxidative stress by total antioxidant capacity (TAC) and total oxidant status (TOS) and oxidative stress index (OSI; TAC/TOS/100) at baseline, first week and third week...
March 15, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28298154/advanced-characterisation-of-encapsulated-lipid-powders-regarding-microstructure-by-time-domain-nuclear-magnetic-resonance
#9
Annika Linke, Theresa Anzmann, Jochen Weiss, Reinhard Kohlus
Encapsulation is an established technique to protect sensitive materials from environmental stress. In order to understand the physical protection mechanism against oxidation, knowledge about the powder microstructure is required. Time domain-nuclear magnetic resonance (TD-NMR) has the potential to determine the surface oil (SO) and droplet size distribution by relaxation and restricted self-diffusion, respectively. The amount of SO, the retention and encapsulation efficiency are determined based on a lipid balance...
March 15, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28295328/oxidative-stability-in-oil-in-water-emulsions-with-quercetin-or-rutin-under-iron-catalysis-or-riboflavin-photosensitization
#10
BoRa Yi, HaeJung Ka, YongJun Kwon, HyungSeok Choi, Sunghwa Kim, Jisu Kim, Mi-Ja Kim, JaeHwan Lee
The effects of quercetin and rutin on the oxidative stability of oil-in-water (O/W) emulsions were tested under riboflavin (RF) photosensitization in the presence or absence of FeCl2 . The degree of oxidation in O/W emulsions was determined by headspace oxygen content, conjugated dienes, and lipid hydroperoxides. Quercetin chelated more metal than did rutin in iron catalyzed O/W emulsions. Generally, 0.1 mM quercetin and rutin was oxidative while 0.5 and 1.0 mM quercetin and rutin was antioxidative in O/W emulsions under RF photosensitization...
March 14, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28293389/exploring-the-effect-of-intravenous-lipid-emulsion-in-acute-methamphetamine-toxicity
#11
Ameneh Ghadiri, Leila Etemad, Mohammad Moshiri, Seyed Adel Moallem, Amir Hossein Jafarian, Farzin Hadizadeh, Mahmoud Seifi
OBJECTIVES: The increasing use of methamphetamine (METH) in the last decades has made it the second most abused drug. Advancs in the area of intravenous lipid emulsion (ILE) have led to its potential application in the treatment of poisoning. The present study aims to investigate the potential role of ILE as an antidote for acute METH poisoning. MATERIALS AND METHODS: Two groups of six male rats were treated by METH (45 mg/kg), intraperitoneally. Five to seven min later, they received an infusion of 18...
February 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28290324/lipid-droplets-coated-with-milk-fat-globule-membrane-fragments-microstructure-and-functional-properties-as-a-function-of-ph
#12
Christelle Lopez, Chantal Cauty, Florence Rousseau, Marielle Blot, Antinéa Margolis, Marie-Hélène Famelart
Processed lipid droplets coated by milk fat globule membrane (MFGM) material are of primary interest to mimic the specific functions provided by the fat globules in milk and dairy products. The objectives were to investigate, as a function of pH, the properties and microstructure of MFGM-coated lipid droplets prepared with an ingredient rich in MFGM containing polar lipids and proteins. The samples were prepared in water and in milk ultrafiltrate. The combination of microscopy techniques, zeta potential and particle size measurements, and rheological determinations was used...
January 2017: Food Research International
https://www.readbyqxmd.com/read/28285019/quantitation-of-monophosphorylated-lipid-a-in-the-oil-in-water-adjuvant-delivery-systems-using-transesterification-and-gc-ms
#13
M Athar Masood, Josip Blonder, Timothy D Veenstra
Vaccine delivery systems play pivotal role in effective antigen delivery. These systems often contain adjuvants that stimulate specific immune response and are important for vaccines' efficacy and safety. Oil-in-water vaccine delivery lipid emulsion systems containing monophosphoryl lipid A (MPLA) as immune modulator have been extensively investigated in vaccine trials. Herein, we describe a simple orthogonal method, for quantitative measurement of MPLA in an oil-in-water lipid delivery system using direct transesterification reaction followed by gas-chromatography-mass spectrometry (GC-MS) analysis...
March 8, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28284919/nanostructured-monolinolein-miniemulsions-as-delivery-systems-role-of-the-internal-mesophase-on-cytotoxicity-and-cell-internalization
#14
Samuel Guillot, Fabienne Méducin, Kristina Poljak, Virginie Malard, Alexandra Foucault-Collet, Sébastien Serieye, Chantal Pichon
Recent advances in nanoparticle systems for improved drug delivery display a great potential for the administration of active molecules. Here, lipid miniemulsions with various internal nanostructures were loaded with the chemotherapeutic agent Paclitaxel. The goal is to assess the impact of internal structures on their efficiency. Previously the structure, the stability and the physico-chemical properties of those carriers were characterized. Modalities of action were addressed by the evaluation of their effects on the tumor cells viability, their cellular uptake by flow cytometry and confocal microscopy detection of fluorescently labeled nanostructured miniemulsions...
March 8, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28280764/lipid-quantitation-and-metabolomics-data-from-vitamin-e-deficient-and-sufficient-zebrafish-embryos-from-0-to-120-hours-post-fertilization
#15
Melissa McDougall, Jaewoo Choi, Hye-Kyeong Kim, Gerd Bobe, J Frederik Stevens, Enrique Cadenas, Robert Tanguay, Maret G Traber
The data herein is in support of our research article by McDougall et al. (2017) [1], in which we used our zebrafish model of embryonic vitamin E (VitE) deficiency to study the consequences of VitE deficiency during development. Adult 5D wild-type zebrafish (Danio rerio), fed defined diets without (E-) or with VitE (E+, 500 mg RRR-α-tocopheryl acetate/kg diet), were spawned to obtain E- and E+ embryos that we evaluated using metabolomics and specific lipid analyses (each measure at 24, 48, 72, 120 hours-post-fertilization, hpf), neurobehavioral development (locomotor responses at 96 hpf), and rescue strategies...
April 2017: Data in Brief
https://www.readbyqxmd.com/read/28279967/ezetimibe-increases-endogenous-cholesterol-excretion-in-humans
#16
Xiaobo Lin, Susan B Racette, Lina Ma, Michael Wallendorf, Richard E Ostlund
OBJECTIVE: Ezetimibe improves cardiovascular outcomes when added to optimum statin treatment. It lowers low-density lipoprotein cholesterol and percent intestinal cholesterol absorption, but the exact cardioprotective mechanism is unknown. We tested the hypothesis that the dominant effect of ezetimibe is to increase the reverse transport of cholesterol from rapidly mixing endogenous cholesterol pool into the stool. APPROACH AND RESULTS: In a randomized, placebo-controlled, double-blind parallel trial in 24 healthy subjects with low-density lipoprotein cholesterol 100 to 200 mg/dL, we measured cholesterol metabolism before and after a 6-week treatment period with ezetimibe 10 mg/d or placebo...
March 9, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28275776/oil-in-water-emulsions-stabilised-by-cellulose-ethers-stability-structure-and-in-vitro-digestion
#17
Jennifer Borreani, María Espert, Ana Salvador, Teresa Sanz, Amparo Quiles, Isabel Hernando
The effect of cellulose ethers in oil-in-water emulsions on stability during storage and on texture, microstructure and lipid digestibility during in vitro gastrointestinal digestion was investigated. All the cellulose ether emulsions showed good physical and oxidative stability during storage. In particular, the methylcellulose with high methoxyl substituents (HMC) made it possible to obtain emulsions with high consistency which remained almost unchanged during gastric digestion, and thus could enhance fullness and satiety perceptions at gastric level...
March 9, 2017: Food & Function
https://www.readbyqxmd.com/read/28273843/effect-of-leaves-of-caesalpinia-decapetala-on-oxidative-stability-of-oil-in-water-emulsions
#18
María Gabriela Gallego, Monika Skowyra, Michael H Gordon, Nurul Aini Mohd Azman, María Pilar Almajano
Caesalpinia decapetala (Roth) Alston (Fabaceae) (CD) is used in folk medicine to prevent colds and treat bronchitis. This plant has antitumor and antioxidant activity. The antioxidant effects of an extract from Caesalpinia decapetala (Fabaceae) were assessed by storage of model food oil-in-water emulsions with analysis of primary and secondary oxidation products. The antioxidant capacity of the plant extract was evaluated by the diphenylpicrylhydrazyl (DPPH), Trolox equivalent antioxidant capacity (TEAC), oxygen radical absorbance capacity (ORAC) and ferric reducing antioxidant power (FRAP) assays and by electron paramagnetic resonance (EPR) spectroscopy...
March 4, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28272377/spotlight-on-biomimetic-systems-based-on-lyotropic-liquid-crystal
#19
REVIEW
Juliana F de Souza, Katiusca da S Pontes, Thais F R Alves, Venâncio A Amaral, Márcia de A Rebelo, Moema A Hausen, Marco V Chaud
The behavior of lyotropic biomimetic systems in drug delivery was reviewed. These behaviors are influenced by drug properties, the initial water content, type of lyotropic liquid crystals (LLC), swell ability, drug loading rate, the presence of ions with higher or less kosmotropic or chaotropic force, and the electrostatic interaction between the drug and the lipid bilayers. The in vivo interaction between LCC-drugs, and the impact on the bioavailability of drugs, was reviewed. The LLC with a different architecture can be formed by the self-assembly of lipids in aqueous medium, and can be tuned by the structures and physical properties of the emulsion...
March 7, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28267037/intravenous-lipid-emulsions-in-pediatric-patients-with-intestinal-failure
#20
Olivier Goulet, Cécile Lambe
The incidence of cholestatic liver disease (CLD) in pediatric patients suffering intestinal failure (IF) is not well established. Due to persistent portal inflammation, about 20% of these patients will progress to end-stage intestinal failure associated liver disease (IFALD) leading to liver transplant or death. PURPOSE OF REVIEW: Premature babies as well as infants with short bowel syndrome (SBS) and repeated sepsis (catheter or small intestinal bacterial overgrowth related) are at risk of developing CLD...
April 2017: Current Opinion in Organ Transplantation
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