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lipidic emulsion

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https://www.readbyqxmd.com/read/28216901/technological-evaluation-of-emulsions-containing-the-volatile-oil-from-leaves-of-plectranthus-amboinicus-lour
#1
Pablo Queiroz Lopes, Fabíola Bernardo Carneiro, Ana Letícia Braz de Sousa, Sócrates Golziodo Santos, Elquio Eleamen Oliveira, Luiz Alberto Lira Soares
BACKGROUND: Plectranthus amboinicus Lour is a species which is widespread throughout tropical countries where it is widely used against respiratory tract disorders such as bronchodilator, antitussive, and expectorant conditions. OBJECTIVE: This study aims to characterize the essential oil of P. amboinicus (PaEO) and produce and evaluate emulsions containing PaEO. MATERIALS AND METHODS: The essential oil was characterized by physical-chemical analyses for density, refractive index, 90% ethanol solubility, color, appearance, and identification by gas chromatography coupled to mass spectrometry detection...
January 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28214850/olive-oil-supplemented-lipid-emulsion-induces-celf1-expression-and-promotes-apoptosis-in-caco-2-cells
#2
Jun-Kai Yan, Jie Zhu, Zi-Zhen Gong, Jie Wen, Yong-Tao Xiao, Wei Cai, Tian Zhang
BACKGROUND AND AIMS: Parenterally-administered lipid emulsion (LE) is a key cause of enterocyte apoptosis under total parenteral nutrition, yet the pathogenesis has not been fully understood. CUGBP, Elav-like family member 1 (CELF1) has been recently identified as a crucial modulator of apoptosis, and thus this study sought to investigate its role in the LE-induced apoptosis in vitro. METHODS: Caco-2 cells were used as an in vitro model. The cells were treated with varying LEs derived from soybean oil, olive oil or fish oil, and changes in the apoptosis and CELF1 expression were assessed...
February 8, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28210396/multivesicular-emulsion-ceramide-containing-moisturizers-an-evaluation-of-their-role-in-the-management-of-common-skin-disorders
#3
REVIEW
Joshua A Zeichner, James Q Del Rosso
Proper stratum corneum function plays a pivotal role in maintenance of skin health, and improper function leads to skin disease. The stratum corneum is comprised of corneocytes surrounded by intercelluar lipids including ceramides, free fatty acids, and cholesterol. Ceramide predominant moisturizers have become a mainstay of treatment of skin disease. New technologies for delivery of ceramides include multivesicular emulsions, which deposit ceramides in a timerelease manner for a continuous rather than burst effect...
December 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28208809/a-lipid-emulsion-reverses-toxic-dose-bupivacaine-induced-vasodilation-during-tyrosine-phosphorylation-evoked-contraction-in-isolated-rat-aortae
#4
Seong-Ho Ok, Soo Hee Lee, Seong-Chun Kwon, Mun Hwan Choi, Il-Woo Shin, Sebin Kang, Miyeong Park, Jeong-Min Hong, Ju-Tae Sohn
The goal of this in vitro study was to examine the effect of a lipid emulsion on toxic-dose bupivacaine-induced vasodilation in a model of tyrosine phosphatase inhibitor sodium orthovanadate-induced contraction in endothelium-denuded rat aortae and to elucidate the associated cellular mechanism. The effect of a lipid emulsion on vasodilation induced by a toxic dose of a local anesthetic during sodium orthovanadate-induced contraction was examined. In addition, the effects of various inhibitors, either bupivacaine alone or a lipid emulsion plus bupivacaine, on protein kinase phosphorylation induced by sodium orthovanadate in rat aortic vascular smooth muscle cells was examined...
February 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28183570/unusual-presentation-of-local-anesthetic-toxicity
#5
Nitin Hayaran, Rashi Sardana, Hamse Nandinie, Aruna Jain
The local anesthetic systemic toxicity can be due to increased blood lignocaine levels or due to increased sensitivity to lignocaine. Several cases of lignocaine-induced central nervous system toxicity have been noted, but none have reported only loss of consciousness without any seizure-like activity. Intravenous lipid emulsion administration for the treatment of local anesthetic systemic toxicity is an emerging topic of discussion, and there are case reports where they had successfully been used. However, majority of them were used in the treatment of cardiovascular manifestations of local anesthetic toxicity...
February 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28183171/impacts-of-post-mortem-ageing-prior-to-freezing-on-technological-and-oxidative-properties-of-coarse-ground-lamb-sausage-in-a-model-system
#6
Ju-Hui Cho, Hyun-Wook Kim, Mustafa M Farouk, Yuan H Brad Kim
Objective: The objective of this study was to evaluate the effects of ageing time of lamb loins prior to freezing on technological characteristics and oxidation stability of coarse ground lamb loin sausage using in a model system. Methods: Lamb loins (M. longissimus lumborum, n=25) were aged at -1.5ºC for 0, 1, 2, 3 and 8 wk and then frozen for the remaining days (a total of 30 wk). The aged/frozen/thawed lamb loins were ground, and model sausages were formulated with 75% aged/frozen/thawed lamb loin, 25% water, 1...
January 26, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28182843/inhibitory-effects-of-red-wine-on-lipid-oxidation-in-fish-oil-emulsion-and-angiogenesis-in-zebrafish-embryo
#7
Haiyan Sun, Yulin Zhang, Yixiao Shen, Yongchao Zhu, Hua Wang, Zhimin Xu
The capabilities of red wine against lipid oxidation and angiogenesis were evaluated by using a fish oil emulsion system and an in vivo zebrafish embryos model, respectively. The red wine contained 12 different antioxidant phenolics which levels were led by anthocyanins (140.46 mg/L), catechin (55.08 mg/L), and gallic acid (46.76 mg/L). The diversity of the phenolics in red wine was greater than the tea, coffee, or white wine selected as a peer control in this study. The total phenolics concentration of red wine was 305...
February 9, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28182087/pretreatment-with-fish-oil-based-lipid-emulsion-modulates-muscle-leukocyte-chemotaxis-in-murine-model-of-sublethal-lower-limb-ischemia
#8
Yao-Ming Shih, Juey-Ming Shih, Yu-Chen Hou, Chiu-Li Yeh, Cheng-Che Li, Sung-Ling Yeh
This study investigated the effects of a fish oil- (FO-) based lipid emulsion on muscle leukocyte chemotaxis and inflammatory responses in a murine model of limb ischemia-reperfusion (IR) injury. Mice were assigned randomly to 1 sham (sham) group, 2 ischemic groups, and 2 IR groups. The sham group did not undergo the ischemic procedure. The mice assigned to the ischemic or IR groups were pretreated intraperitoneally with either saline or FO-based lipid emulsion for 3 consecutive days. The IR procedure was induced by applying a 4...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28181841/surface-density-of-polyarginine-influence-the-size-zeta-potential-cellular-uptake-and-tissue-distribution-of-the-nanostructured-lipid-carrier
#9
Mingshuang Sun, Zhihong Zhu, Huixin Wang, Cuiyan Han, Dandan Liu, Lei Tian, Xinggang Yang, Weisan Pan
Poly-arginines are strong tools to elevate the cellular uptake of nanopreparations. To learn the influence of poly-arginine (RRRRRRRR, R8) density on a series of properties of nanostructured lipid carrier (NLC), we build six R8 modified NLCs with different R8 densities (nR-NLC, where n represents the R8 ratio) by fusion-emulsion method with the aid of stearyl-R8. The pharmaceutical characteristics like size, zeta potential and in vitro drug release, cellular uptake, cytotoxicity to A549 cells and tissue distribution in S180 tumor-bearing mice of the six nR-NLCs are all investigated...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28165891/dispersion-and-oxidative-stability-of-o-w-emulsions-and-oxidation-of-microencapsulated-oil
#10
Yayoi Miyagawa, Shuji Adachi
Oil-in-water (O/W) emulsions are among the dispersion systems commonly used in food, and these emulsions are in thermodynamically unstable or metastable states. In this paper, various methods for preparing O/W emulsions are outlined. Since the commodity value of food is impaired by the destabilization of O/W emulsions, experimental and theoretical approaches to assess the stability of O/W emulsions are overviewed, and factors affecting the dispersion stability of emulsions are discussed based on the DLVO theory and the concept of the stability factor...
February 6, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28165858/plga-nanoparticles-for-the-oral-delivery-of-nuciferine-preparation-physicochemical-characterization-and-in-vitro-in-vivo-studies
#11
Ying Liu, Xin Wu, Yushuai Mi, Bimeng Zhang, Shengying Gu, Gaolin Liu, Xiaoyu Li
This article reports a promising approach to enhance the oral delivery of nuciferine (NUC), improve its aqueous solubility and bioavailability, and allow its controlled release as well as inhibiting lipid accumulation. NUC-loaded poly lactic-co-glycolic acid nanoparticles (NUC-PLGA-NPs) were prepared according to a solid/oil/water (s/o/w) emulsion technique due to the water-insolubility of NUC. PLGA exhibited excellent loading capacity for NUC with adjustable dosing ratios. The drug loading and encapsulation efficiency of optimized formulation were 8...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28165812/the-protective-effect-of-lipid-emulsion-in-preventing-bupivacaine-induced-mitochondrial-injury-and-apoptosis-of-h9c2-cardiomyocytes
#12
Zhe Chen, Zhousheng Jin, Yun Xia, Shishi Zhao, Xuzhong Xu, Thomas J Papadimos, Quanguang Wang
Lipid emulsion (LE) has been shown to be effective in the resuscitation of bupivacaine-induced cardiac arrest, but the precise mechanism of this action has not been fully elucidated. Pursuant to this lack of information on the mechanism in which LE protects the myocardium during bupivacaine-induced toxicity, we explored mitochondrial function and cell apoptosis. H9C2 cardiomyocytes were used in study. Cells were randomly divided in different groups and were cultivated 6 h, 12 h, and 24 h. The mitochondria were extracted and mitochondrial ATP content was measured, as was mitochondrial membrane potential, the concentration of calcium ion (Ca2+), and the activity of Ca2+-ATP enzyme (Ca2+-ATPase)...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28161466/cmrna-lipoplex-encapsulation-in-plga-microspheres-enables-transfection-via-calcium-phosphate-cement-cpc-plga-composites
#13
Maximilian Utzinger, Anita Jarzebinska, Nicolas Haag, Martin Schweizer, Gerhard Winter, Christian Dohmen, Carsten Rudolph, Christian Plank
In this study lipoplexes containing chemically modified messenger RNA (cmRNA) were incorporated into poly (lactic-co-glycolic acid) (PLGA) microspheres via water-in-oil-in-water (W/O/W) double emulsion solvent evaporation technique. The nanoparticle encapsulation by microparticle formation was optimized to achieve lipoplex release and maximum transfection efficiency in surrounding cells. It was possible to adjust characteristic features in surface topology and size of the PLGA-microspheres by varying the extent of lipoplex loading into the polymer matrix...
February 2, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28161464/mycobacterium-tuberculosis-proteins-involved-in-cell-wall-lipid-biosynthesis-improve-bcg-vaccine-efficacy-in-a-murine-tb-model
#14
REVIEW
Martin Rao, Nathalie Cadieux, Megan Fitzpatrick, Steven Reed, Sergei Arsenian, Davide Valentini, Shreemanta Parida, Ernest Dodoo, Alimuddin Zumla, Markus Maeurer
OBJECTIVES: Advances in tuberculosis (TB) vaccine development are urgently required to enhance global disease management. We evaluated the potential of Mycobacterium tuberculosis (M. tb)-derived protein antigens Rv0447c, Rv2957 and Rv2958c to boost BCG vaccine efficacy in the presence or absence of glucopyranosyl lipid adjuvant formulated in a stable emulsion (GLA-SE) adjuvant. METHODS: Mice received the BCG vaccine, followed by Rv0447c, Rv2957 and Rv2958c protein boosting with or without GLA-SE adjuvant 3 and 6 weeks later...
February 2, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28152634/effect-of-solid-lipid-s-structure-on-nanostructured-lipid-carriers-encapsulated-with-sun-filter-characterization-photo-stability-and-in-vitro-release
#15
Ke Wang, Qianjie Zhang, Yu-Lian Miao, Shao-Qiang Luo, Hong-Cai Wang, Wan-Ping Zhang
Three series of solid lipid are formulated in lipid nanoparticles carrier (NLC) system which encapsulated with sun filter to evaluate the effect on the physicochemical properties of the nanocarriers. Production is performed by ultrasonication-homogenization, analysis by particle size, Zeta Potential (ZP), Transmission Electron Microscope (TEM), Fourier Transform Infrared Spectroscopy (FT-IR), Differential Scanning Calorimetry (DSC), X-ray Diffraction (XRD). Moreover, the Encapsulation Efficiency (EE), Ultraviolet (UV) performance and in vitro release are also investigated...
February 3, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28133759/hydroxytyrosol-extracts-olive-oil-and-walnuts-as-functional-components-in-chicken-sausages
#16
Gema Nieto, Lorena Martínez, Gaspar Ros
BACKGROUND: Olive oil, hydroxytyrosol and walnut can be considered ideal Mediterranean ingredients for their high polyphenolic content and healthy properties. Three extracts of hydroxytyrosol obtained using different extraction process (HXT 1, 2, 3) (50 ppm) were evaluated for use as antioxidants in eight different chicken sausage formulas enriched in polyunsaturated fatty acids (2.5 g/100 g walnut) or using extra virgin olive oil (20 g/100 g) as fat replacer. Lipid and protein oxidation, colour, emulsion stability, and the microstructure of the resulting chicken sausages were investigated and a sensory analysis was carried out...
January 30, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28126549/leaching-of-plasticizers-from-polyvinylchloride-perfusion-lines-by-different-lipid-emulsions-for-premature-infants-under-clinical-conditions
#17
David Faessler, Gregor McCombie, Maurus Biedermann, Florian Felder, Ulrike Subotic
Plasticizers migrate from polyvinylchloride (PVC) infusion systems into lipid emulsions. The aim of this study was to investigate the leaching of different plasticizers from PVC perfusion lines by a selection of lipid emulsions under clinical conditions. Seven PVC perfusion lines with an equal length of 150cm and three internal diameters were perfused with three lipid emulsions: Intralipid(®) 20%, ClinOleic(®) 20% and SMOFlipid(®) 20%, mimicking clinical conditions. The concentrations of the plasticizers were measured directly in the emulsions by gas chromatography - mass spectrometry...
January 23, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28125342/edible-nanoemulsions-as-carriers-of-active-ingredients-a-review
#18
Laura Salvia-Trujillo, Robert C Soliva-Fortuny, M Alejandra Rojas-Graü, D Julian McClements, Olga Martín-Belloso
There has been growing interest in the use of edible nanoemulsions as delivery systems for lipophilic active substances, such as oil-soluble vitamins, antimicrobials, flavors, and nutraceuticals, because of their unique physicochemical properties. Oil-in-water nanoemulsions consist of oil droplets with diameters typically between approximately 30 and 200 nm that are dispersed within an aqueous medium. The small droplet size usually leads to an improvement in stability, gravitational separation, and aggregation...
January 11, 2017: Annual Review of Food Science and Technology
https://www.readbyqxmd.com/read/28117946/clearance-of-plasma-ivermectin-with-single-pass-lipid-dialysis-in-2-dogs
#19
Leonel A Londoño, Gareth J Buckley, Luiz Bolfer, Carsten Bandt
OBJECTIVE: To describe the use of single pass lipid dialysis (SPLD) for treatment of ivermectin toxicosis in 2 Australian Shepherd dogs with the ABCB1-1Δ gene mutation. CASE SERIES SUMMARY: Two Australian Shepherd dogs were presented for treatment of ivermectin toxicosis. Dogs were initially treated with intravenous lipid emulsion and supportive care, without improvement of clinical signs. They both developed respiratory paralysis and required mechanical ventilation...
January 24, 2017: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/28116392/the-influence-of-lipid-droplet-size-on-the-oral-bioavailability-of-vitamin-d2-encapsulated-in-emulsions-an-in-vitro-and-in-vivo-study
#20
L Salvia-Trujillo, B Fumiaki, Y Park, D J McClements
Vitamin D deficiency is prevalent in some populations leading to adverse health effects, and therefore there is a need to supplement functional foods and beverages with this important micronutrient. In this study, we examined the influence of the initial lipid droplet size on the in vitro bioaccessibility and in vivo absorption of vitamin D2 encapsulated in oil-in-water emulsions. Changes in particle size, charge, and microstructure were measured as vitamin-loaded lipid droplets were passed through a simulated GIT (mouth, stomach, small intestine)...
January 24, 2017: Food & Function
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