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lipidic emulsion

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https://www.readbyqxmd.com/read/29792199/nanoparticle-delivery-of-grape-seed-derived-proanthocyanidins-to-airway-epithelial-cells-dampens-oxidative-stress-and-inflammation
#1
S Castellani, A Trapani, A Spagnoletta, L di Toma, T Magrone, S Di Gioia, D Mandracchia, G Trapani, E Jirillo, M Conese
BACKGROUND: Chronic respiratory diseases, whose one of the hallmarks is oxidative stress, are still incurable and need novel therapeutic tools and pharmaceutical agents. The phenolic compounds contained in grape are endowed with well-recognized anti-oxidant, anti-inflammatory, anti-cancer, and anti-aging activities. Considering that natural anti-oxidants, such as proanthocyanidins, have poor water solubility and oral bioavailability, we have developed a drug delivery system based on solid lipid nanoparticles (SLN), apt to encapsulate grape seed extract (GSE), containing proanthocyanidins...
May 23, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29789518/olive-oil-and-soybean-oil-based-intravenous-lipid-emulsions-liver-biochemistry-and-clinical-outcomes
#2
Fabio Araujo, Tanis R Fenton, Sara Lukmanji, Maitreyi Raman
Intravenous lipid emulsions are an essential component of parenteral nutrition (PN). Omega-6 reducing strategies may improve outcomes, including reduced PN associated liver disease, however evidence to support this recommendation is insufficient. The primary objective was to compare serum alkaline phosphatase (ALP), among patients provided with either soybean oil (Intralipid) or predominantly olive oil (Clinoleic) lipid emulsions. In this quasi-experimental study, we reviewed the medical records of surgical and medical adult patients who received lipid emulsions for at least seven consecutive days...
May 23, 2018: Nutrients
https://www.readbyqxmd.com/read/29777856/ocular-irritation-and-cyclosporine-a-distribution-in-the-eye-tissues-after-administration-of-solid-lipid-microparticles-in-the-rabbit-model
#3
Eliza Wolska, Małgorzata Sznitowska, Juliusz Chorążewicz, Oliwia Szerkus, Aleksandra Radwańska, Michał J Markuszewski, Roman Kaliszan, Krystyna Raczyńska
The aim of this study was to investigate the in vivo effect of Solid Lipid Microparticles (SLM), proposed for topical ocular administration of cyclosporine, on the rabbit eye. SLM carrier is an aqueous dispersion of lipid microparticles (20% w/w) with a size up to 15 μm. Cyclosporine was dissolved in the formulation in the concentration of 0.5 or 2.0% (w/w). Ocular tolerance of microsphere dispersion was assessed in rabbit model by the Draize eye test (SLM was compared with emulsion and oily solution), and cyclosporine distribution in ocular tissues was evaluated after multiple application of tested formulations (SLM dispersions, emulsions and oily solution) for 7 days...
May 16, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29775655/confocal-raman-microspectroscopy-as-an-alternative-to-differential-scanning-calorimetry-to-detect-the-impact-of-emulsifiers-and-formulations-on-stratum-corneum-lipid-conformation
#4
Ziwei Zhang, Dominique Jasmin Lunter
The purpose of this study was to investigate the impact of emulsifiers and formulations on stratum corneum (SC) lipid conformation and evaluate confocal Raman microspectroscopy (CRM) as an alternative method to differential scanning calorimetry (DSC) in this research context. To this end, four different formulations were used: three conventional creams that contained ionic and/or non-ionic emulsifiers and one surfactants-free emulsion stabilized by a polymeric emulsifier. Additionally, all emulsifiers were tested in aqueous solutions/dispersions in the respective concentrations as present in the formulations...
May 15, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29769270/effective-combination-adjuvants-engage-both-tlr-and-inflammasome-pathways-to-promote-potent-adaptive-immune-responses
#5
Emilie Seydoux, Hong Liang, Natasha Dubois Cauwelaert, Michelle Archer, Nicholas D Rintala, Ryan Kramer, Darrick Carter, Christopher B Fox, Mark T Orr
The involvement of innate receptors that recognize pathogen- and danger-associated molecular patterns is critical to programming an effective adaptive immune response to vaccination. The synthetic TLR4 agonist glucopyranosyl lipid adjuvant (GLA) synergizes with the squalene oil-in-water emulsion (SE) formulation to induce strong adaptive responses. Although TLR4 signaling through MyD88 and TIR domain-containing adapter inducing IFN-β are essential for GLA-SE activity, the mechanisms underlying the synergistic activity of GLA and SE are not fully understood...
May 16, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29764126/molecular-simulation-of-the-water-triolein-oleic-acid-mixture-local-structure-and-thermodynamic-properties
#6
E Couallier, A Riaublanc, E David Briand, B Rousseau
An artificial oil-in-water emulsion analogous to those found in bioresources or food matrices is simulated and studied experimentally. It is composed of one of the major natural free fatty acids (the oleic acid, OA) and the corresponding triacylglyceride (trioleic glyceride, or triolein, GTO). Because of the large time and length scales involved, the molecular simulations are done with the Martini force field, a coarse-grained model. This allowed us to study the water-OA-GTO system at different compositions with more than 20 000 molecules and up to 2 μs...
May 14, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29763687/therapeutic-efficacy-of-lipid-emulsions-of-docetaxel-linoleic-acid-conjugate-in-breast-cancer
#7
Tao Zhang, Meng Li, Ruyi Yang, Dong Zhang, Jibin Guan, Jiang Yu, Bin Yang, Huicong Zhang, Shenwu Zhang, Dan Liu, Yongjun Wang
Docetaxel (DTX) solution is among the most widely-used parenteral formulations used in advanced breast cancer therapy. However, severe side effects have been observed due to the use of ethanol and polysorbate 80. Herein, a novel DTX-based prodrug, docetaxel-linoleic acid conjugate (DTX-LA) was successfully synthesized. The high lipid solubility of DTX and DTX-LA resulted in a tendency for them to become entrapped in the oil core of the emulsions. As anticipated, nano-sized, sterically stabilized oil-in-water lipid emulsions (LMs) of DTX-LA LMs and DTX LMs were successfully constructed...
May 12, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29762225/tsujikawa-and-lipid-emulsion
#8
Josh J Wang, Eric Villeneuve, Sophie Gosselin, Susan C Smolinske, Lotte C G Hoegberg, Robert S Hoffman
No abstract text is available yet for this article.
June 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29760705/induction-of-cytotoxic-t-lymphocyte-responses-upon-subcutaneous-administration-of-a-subunit-vaccine-adjuvanted-with-an-emulsion-containing-the-toll-like-receptor-3-ligand-poly-i-c
#9
Signe Tandrup Schmidt, Gabriel Kristian Pedersen, Malene Aaby Neustrup, Karen Smith Korsholm, Thomas Rades, Peter Andersen, Camilla Foged, Dennis Christensen
There is an unmet medical need for new subunit vaccines that induce cytotoxic T-lymphocyte (CTL) responses to prevent infection with a number of pathogens. However, stimulation of CTL responses via clinically acceptable subcutaneous (s.c.) and intramuscular (i.m.) injection is challenging. Recently, we designed a liposomal adjuvant [cationic adjuvant formulation (CAF)09] composed of the cationic lipid dimethyldioctadecylammonium (DDA) bromide, a synthetic monomycoloyl glycerol analog and polyinosinic:polycytidylic acid, which induce strong CTL responses to peptide and protein antigens after intraperitoneal administration...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29751903/pectin-influences-the-kinetics-of-in-vitro-lipid-digestion-in-oil-in-water-emulsions
#10
S H E Verkempinck, L Salvia-Trujillo, S Denis, A M Van Loey, M E Hendrickx, T Grauwet
Oil-in-water emulsions were prepared with 5% (w/v) carrot-enriched olive oil and stabilized with Tween 80 (TW), phosphatidylcholine (PC), citrus pectin (CP) or a combination of these emulsifiers. Additionally, the methylesterification degree (DM) of citrus pectin was modified, resulting in three different studied pectin structures: CP82, CP38 and CP10. All initial emulsions presented small initial oil droplet sizes and were submitted to an in vitro simulated gastric and small intestinal phase. The latter was executed in a kinetic way to determine the time dependency of the lipolysis reaction, micelle formation and carotenoid bioaccessibility...
October 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29750663/free-fatty-acid-receptor-g-protein-coupled-receptor-40-mediates-lipid-emulsion-induced-cardioprotection-erratum
#11
(no author information available yet)
No abstract text is available yet for this article.
May 10, 2018: Anesthesiology
https://www.readbyqxmd.com/read/29748832/optimization-and-evaluation-of-lipid-emulsions-for-intravenous-co-delivery-of-artemether-and-lumefantrine-in-severe-malaria-treatment
#12
Yinxian Yang, Hailing Gao, Shuang Zhou, Xiao Kuang, Zhenjie Wang, Hongzhuo Liu, Jin Sun
Parenteral therapy for severe and complicated malaria is necessary, but currently available parenteral antimalarials have their own drawbacks. As for recommended artemisinin-based combination therapy, antimalarial artemether and lumefantrine are limited in parenteral delivery due to their poor water solubility. Herein, the aim of this study was to develop the lipid-based emulsions for intravenous co-delivery of artemether and lumefantrine. The lipid emulsion was prepared by high-speed shear and high-pressure homogenization, and the formulations were optimized mainly by monitoring particle size distribution under autoclaved conditions...
May 10, 2018: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29745326/a-novel-surfactant-free-lipid-based-formulation-for-improving-oral-bioavailability-of-loratadine-using-colloidal-silicon-dioxide-as-emulsifier-and-solid-carrier
#13
Ri Huang, Yonggang Tan, Lao Shen, Tao Wang, Dongqin Quan
BACKGROUND: The purpose of this study was to develop an innovative surfactant-free lipid-based formulation (LF) for improving oral bioavailability of loratadine based on using solid particles colloidal silicon dioxide (CSD) as emulsifier and solid carrier. METHODS: Loratadine was dissolved in oil solution with the aid of co-solvent and LF were prepared by a simple adsorption and milling technique. The LF Powder was evaluated in terms of angle of repose and X-ray powder diffraction...
May 8, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29744376/cell-sized-lipid-vesicles-for-cell-cell-synaptic-therapies
#14
D Vallejo, S H Lee, D Lee, C Zhang, C Rapier, S D Chessler, A P Lee
Cell-sized lipid vesicles (CLVs) have shown great promise for therapeutic and artificial cell applications, but their fragility and short shelf life has hindered widespread adoption and commercial viability. We present a method to circumvent the storage limitations of CLVs such as giant unilamellar vesicles (GUVs) and single-compartment multisomes (SCMs) by storing them in a double emulsion precursor form. The double emulsions can be stored for at least 8 months and readily converted into either GUVs or SCMs at any time...
December 2017: Technology
https://www.readbyqxmd.com/read/29734771/a-method-for-efficient-loading-of-ciprofloxacin-hydrochloride-in-cationic-solid-lipid-nanoparticles-formulation-and-microbiological-evaluation
#15
Rosario Pignatello, Antonio Leonardi, Virginia Fuochi, Giulio Petronio Petronio, Antonio S Greco, Pio Maria Furneri
The aim of the study was the production of solid lipid nanoparticles (SLN) loaded with ciprofloxacin (CIP) through two different production techniques, quasi-emulsion solvent diffusion (QESD) and solvent injection (SI). In order to efficaciously entrap the commercial salt form (hydrochloride) of the antibiotic in these lipid systems, a conversion of CIP hydrochloride to the free base was realized in situ, through the addition of triethylamine. To ensure physical stability to the carriers over time and ameliorate the interaction with bacterial cell membranes, positively charged SLN were produced by addition of the cationic lipid didecyldimethylammonium bromide (DDAB)...
May 6, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29734004/application-of-winter-mushroom-powder-as-an-alternative-to-phosphates-in-emulsion-type-sausages
#16
Jeehwan Choe, Juri Lee, Kyung Jo, Cheorun Jo, Minho Song, Samooel Jung
This research evaluated the utilization of winter mushrooms as a replacement for phosphate in emulsion-type sausages. Winter mushroom powder (WMP) was added to the sausages at 0, 0.5, 1.0, 1.5, and 2.0% (w/w), and phosphate was added at 0.3% as a positive control. The WMP additions above 1.0% increased the pH of meat batter and efficiently inhibited the exudation of fat from the sausages (p < 0.05). Lipid oxidation of sausages was inhibited by the addition of WMP (p < 0.05). On the other hand, the addition of phosphate and WMP provided different instrumental texture properties...
May 1, 2018: Meat Science
https://www.readbyqxmd.com/read/29730982/phytosterol-determination-in-lipid-emulsions-for-parenteral-nutrition
#17
Josep M Llop Talaverón, Ana Novak, Josep M Suñé Negre, María Badia Tahull, Elisabet Leiva Badosa, Josep R Ticó Grau
OBJECTIVE: The presence of phytosterols in vegetal lipid emulsions has been  associated with alterations of liver function tests. Determination of phytosterols  content, currently undeclared, would allow the development of strategies to  prevent or treat these alterations. METHOD: 3-4 non-consecutive batches of 6 lipid emulsions from different providers (Clinoleic, Intralipid, Lipofundina, Lipoplus, Omegaven and Smoflipid) were analyzed. Differences in total phytosterol assay between providers and batches were statistically studied by a one-way ANOVA and Kruskal-Wallis non-parametric approximation and post hoc Scheffé test (p &lt; 0...
May 1, 2018: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/29725909/oral-administration-of-lipid-oil-in-water-emulsions-performed-with-synthetic-or-protein-type-emulsifiers-differentially-affects-post-prandial-triacylglycerolemia-in-rats
#18
Merian Nassra, Christine Bourgeois, Muriel Subirade, Patrick Sauvant, Claude Atgié
In this study, we compared the impact of administration of size-calibrated lipid emulsions prepared with either synthetic or natural emulsifiers on the post-absorptive plasma triacylglycerol responses in rats. We did this using four types of size-calibrated (10 μm diameter) and metastable (3 days) emulsions with 20% of an oleic acid-rich sunflower oil and 1% of either synthetic emulsifiers (Tween 80 or sodium 2-stearoyl-lactylate) or two proteins (β-lactoglobulin or sodium caseinate). An oral fat tolerance test was performed in fasted rats by oral administration of each of these formulations in continuous or emulsified forms...
May 3, 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29725222/effects-of-jerusalem-artichoke-powder-and-sodium-carbonate-as-phosphate-replacers-on-the-quality-characteristics-of-emulsified-chicken-meatballs
#19
Burcu Öztürk, Meltem Serdaroğlu
Today incorporation of natural ingredients as inorganic phosphate replacers has come into prominence as a novel research topic due to health concerns about phosphates. In this study, we aimed to investigate the quality of emulsified chicken meatballs produced with Jerusalem artichoke powder (JAP), either alone or in combination with sodium carbonate (SC) as sodium tripolyphosphate (STPP) replacers. The results showed that naturally dried JAP showed favorable technological properties in terms of water-oil binding and gelling...
February 2018: Korean Journal for Food Science of Animal Resources
https://www.readbyqxmd.com/read/29717664/lipids-and-surfactants-the-inside-story-of-lipid-based-drug-delivery-systems
#20
Vikas Pandey, Seema Kohli
In the bioavailability enhancement of poorly aqueous soluble drugs, self-emulsifying/microemulsifying drug delivery systems (SEDDS/SMEDDS) are isotropic mixtures of oils, surfactants, solvents, and cosolvents/surfactants that have gained immense popularity because of their self-emulsification ability. This characteristic relies on some critical parameters such as surfactant concentration, oil-to-surfactant ratio, polarity of the emulsion, droplet size and charge, which are acquired from an amalgamation of appropriate excipients...
2018: Critical Reviews in Therapeutic Drug Carrier Systems
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