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lipidic emulsion

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https://www.readbyqxmd.com/read/28526935/diabetes-induced-abnormalities-of-mitochondrial-function-in-rat-brain-cortex-the-effect-of-n-3-fatty-acid-diet
#1
Maria Chomova, Maria Balazova, Jana Muchova
Diabetic encephalopathy, a proven complication of diabetes is associated with gradually developing end-organ damage in the CNS increasing the risk of stroke, cognitive dysfunction or Alzheimer's disease. This study investigated the response of rat cortical mitochondria to streptozotocin-induced diabetes and the potential for fish oil emulsion (FOE) to modulate mitochondrial function. Diabetes-induced deregulation of the respiratory chain function as a result of diminished complex I activity (CI) and cytochrome c oxidase hyperactivity was associated with attenuation of antioxidant defense of isolated cortical mitochondria, monitored by SOD activity, the thiol content, the dityrosine and protein-lipid peroxidation adduct formation...
May 19, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28515938/accounting-for-adjuvant-induced-artifacts-in-the-characterization-of-vaccine-formulations-by-polyacrylamide-gel-electrophoresis
#2
Virginie Jakob, Livia Brunner, Christophe Barnier-Quer, Molly Blust, Nicolas Collin, Lauren Carter, Darrick Carter, Kelly M Rausch, Christopher B Fox
OBJECTIVES: Several vaccine adjuvants comprise complex nano- or micro-particle formulations, such as oil-in-water emulsions. In order to characterize interactions and compatibility of oil-in-water emulsion adjuvants with protein antigens in vaccines, effective protein characterization methods that can accommodate potential interference from high concentrations of lipid-based particles are needed. METHODS: Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) is a standard protein characterization technique which is affected by the presence of adjuvants such as oil-in-water emulsions...
April 2017: Therapeutic Advances in Vaccines
https://www.readbyqxmd.com/read/28515648/evaluation-of-antioxidative-activity-of-various-levels-of-ethanol-extracted-tomato-powder-and-application-to-pork-patties
#3
Hyeong Sang Kim, Koo Bok Chin
This study was performed to evaluate antioxidant activity of tomato powder extracted by various concentrations of ethanol (0, 25, 50, 75, 100%) and to evaluate the physicochemical properties and antioxidant activities of pork patties with ethanol extracted tomato (EET) powder. No differences in the contents of total of individual phenolic compounds including gallic acid and catechin, were observed among the treatments (p>0.05). Among the various concentrations, 50% and 75% EET powder showed the highest free radical scavenging and iron chelating activities (p<0...
2017: Korean Journal for Food Science of Animal Resources
https://www.readbyqxmd.com/read/28514346/-systemic-toxicity-of-local-anesthetics
#4
S A Rabinovich, L A Zavodilenko
The paper presents characteristics of local anesthetics used in dentistry and maxillofacial surgery taking into account their effectiveness and toxicity. We described the main clinical symptoms of manifestation of systemic toxicity and measures for prevention of local anesthesia complications, as well as the detailed protocol of 'lipid rescue' and resuscitation at manifestation of systemic toxic reaction of local anesthetics with the mechanism of the fatty emulsion action.
2017: Stomatologii︠a︡
https://www.readbyqxmd.com/read/28512779/structure-of-protein-emulsion-in-food-impacts-intestinal-microbiota-caecal-luminal-content-composition-and-distal-intestine-characteristics-in-rats
#5
Martin Beaumont, Daphné Jaoui, Véronique Douard, Damien Mat, Fanny Koeth, Bénédicte Goustard, Camille Mayeur, Stanislas Mondot, Anais Hovaghimian, Steven Le Feunteun, Catherine Chaumontet, Anne-Marie Davila, Daniel Tomé, Isabelle Souchon, Camille Michon, Gilles Fromentin, François Blachier, Marion Leclerc
SCOPE: Few studies have evaluated in vivo the impact of food structure on digestion, absorption of nutrients and on microbiota composition and metabolism. In this study we evaluated in rat the impact of two structures of protein emulsion in food on gut microbiota, luminal content composition, and intestinal characteristics. METHODS AND RESULTS: Rats received for 3 weeks two diets of identical composition but based on lipid-protein matrices of liquid fine (LFE) or gelled coarse (GCE) emulsion...
May 17, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28509770/tumescent-anaesthesia-its-applications-and-well-tolerated-use-in-the-out-of-operating-room-setting
#6
Natalie F Holt
PURPOSE OF REVIEW: Tumescent anaesthesia is a method of administering dilute local anaesthetic into the subcutaneous tissue. Many anaesthesiologists are unfamiliar with the technique, its applications and potential risks. RECENT FINDINGS: The maximum safe dose of lidocaine with epinephrine in tumescent anaesthesia for liposuction is probably between 35 and 55 mg/kg. Without liposuction, the maximum dose of lidocaine with epinephrine should be no more than 28 mg/kg...
May 15, 2017: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/28506439/clinical-review-loperamide-toxicity
#7
REVIEW
Peter E Wu, David N Juurlink
Loperamide is a nonprescription opioid widely used for the treatment of diarrhea. Although it is relatively safe at therapeutic doses, increasing reports describe its misuse and abuse at very high doses either for euphoric effects or to attenuate symptoms of opioid withdrawal. Life-threatening loperamide toxicity can result from the relatively new clinical syndrome of loperamide-induced cardiac toxicity. These patients are often young and may present in cardiac arrest or with unheralded, recurrent syncope in conjunction with ECG abnormalities, including marked QT-interval prolongation, QRS-interval widening, and ventricular dysrhythmias...
May 13, 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28502090/successful-use-of-lipid-emulsion-to-resuscitate-a-foal-after-intravenous-lidocaine-induced-cardiovascular-collapse
#8
V Vieitez, I Á Gómez de Segura, M Martin-Cuervo, L Alfonso Gracia, L Javier Ezquerra
BACKGROUND: Lipid emulsion has been reported to be effective for the treatment of local anaesthetic overdoses in rats, dogs and humans. OBJECTIVES: To describe the successful treatment of cardiovascular lidocaine toxicity in a foal with intravenous lipid administration. STUDY DESIGN: Observational study: case report. METHODS: An 8-month-old Arabian cross foal was anaesthetised for removal of the right alar fold and nasal plate...
May 14, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/28493610/fractionated-aliphatic-alcohols-as-synthetic-precursors-of-ultra-long-chain-monoacylglycerols-for-cosmetic-applications
#9
Bianca Pérez, Bjørn S Hansen, Pallav A Bulsara, Anthony Vincent Rawlings, Martyn J Clarke, Zheng Guo
BACKGROUND: Xerosis is an abnormally dry and flaky skin condition that is associated with a change in the packing behavior of the lipid matrix in the stratum corneum (SC), the outermost layer of the skin. This skin condition can lead to an increase in transepidermal water loss (TEWL). Since ultralong chain fatty acids have a positive effect on maintaining the packing behavior of the SC lipid matrix, a moisturizer which contains glycerides of ultralong chain fatty acids could act as an semi-occlusive layer on the surface of the skin...
May 11, 2017: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/28492305/monitoring-interfacial-lipid-oxidation-in-oil-in-water-emulsions-using-spatially-resolved-optical-techniques
#10
Chiranjib Banerjee, Michael Westberg, Thomas Breitenbach, Mikkel Bregnhøj, Peter R Ogilby
The oxidation of lipids is an important phenomenon with ramifications for disciplines that range from food science to cell biology. The development and characterization of tools and techniques to monitor lipid oxidation are thus relevant. Of particular significance in this regard are tools that facilitate the study of oxidations at interfaces in heterogeneous samples (e.g., oil-in-water emulsions, cell membranes). In this article, we establish proof-of-principle for methods to initiate and then monitor such oxidations with high spatial resolution...
May 11, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28490055/carotenoid-bioaccessibility-and-the-relation-to-lipid-digestion-a-kinetic-study
#11
Leonard Mutsokoti, Agnese Panozzo, Andrea Pallares Pallares, Swati Jaiswal, Ann Van Loey, Tara Grauwet, Marc Hendrickx
The micellar incorporation of carotenoids (lycopene, α- and β-carotene) and lipid digestion products (free fatty acids, FFAs, and monoacylglycerides, MAGs) during in vitro digestion of oil-in-water emulsions was investigated by a kinetic approach. A fractional conversion model could adequately describe the hydrolysis of triacylglycerides, formation of FFAs and MAGs, and micellar incorporation of carotenoids, FFAs and MAGs. The release of FFAs and MAGs from TAGs proceeded faster than their incorporation into micelles...
October 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28489457/adverse-events-associated-with-a-large-dose-of-intravenous-lipid-emulsion-for-suspected-local-anesthetic-toxicity
#12
Daniel J Corwin, Alexis Topjian, Brenda L Banwell, Kevin Osterhoudt
BACKGROUND: Intravenous lipid emulsion (ILE) has gained favor as a rescue treatment for cardiovascular collapse due to intravenous local anesthetic overdose, however, goals of ILE therapy are still being defined. We describe a case of a girl given 66 mL/kg of 20% lipid emulsion (ILE) in the treatment of presumed mepivacaine toxicity. CASE REPORT: An 11-year-old girl weighing 55.6 kg developed pallor, rolling back of the eyes, and rhythmic muscle twitching after receiving a mandibular nerve block injection with a 1...
July 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28479357/hexagonal-liquid-crystalline-nanodispersions-proven-superiority-for-enhanced-oral-delivery-of-rosuvastatin-in-vitro-characterization-and-in-vivo-pharmacokinetic-study
#13
Mai Mahmoud Gabr, Sana Mohamed Mortada, Marwa Ahmed Sallam
This study aimed to explore the potential of tailoring the liquid crystalline structure for augmenting the oral absorption and biopharmaceutical performance of Rosuvastatin. Rosuvastatin-loaded liquid crystalline nanodispersions (LCNDs) were prepared via emulsification technique. The effect of incorporating oleic acid (OA) in various proportions in the lipid domain of the LCNDs was studied. The formulations were characterized for particle size, zeta potential, in-vitro release, ex-vivo intestinal permeation, in-vivo oral bioavailability and stability...
May 4, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28476930/mitochondrial-targeted-catalase-protects-against-high-fat-diet-induced-muscle-insulin-resistance-by-decreasing-intramuscular-lipid-accumulation
#14
Hui-Young Lee, Jae Sung Lee, Tiago Alves, Warren Ladiges, Peter S Rabinovitch, Michael J Jurczak, Cheol Soo Choi, Gerald I Shulman, Varman T Samuel
We explored the role of reactive oxygen species (ROS) in the pathogenesis of muscle insulin resistance by assessing insulin action in vivo with a hyperinsulinemic-euglycemic clamp in mice expressing a mitochondrially-targeted catalase (MCAT) that were fed regular chow (RC), a high-fat diet (HFD), or undergoing an acute infusion of a lipid emulsion. RC MCAT mice were similar to littermate wild-type (WT) mice. However, HFD MCAT mice were protected from diet-induced insulin resistance. In contrast, an acute lipid infusion caused muscle insulin resistance in both MCAT and WT mice...
May 5, 2017: Diabetes
https://www.readbyqxmd.com/read/28476598/the-smooth-hound-lipolytic-system-biochemical-characterization-of-a-purified-digestive-lipase-lipid-profile-and-in-vitro-oil-digestibility
#15
Neila Achouri, Nabil Smichi, Youssef Gargouri, Nabil Miled, Ahmed Fendri
In order to identify fish enzymes displaying novel biochemical properties, we choose the common smooth-hound (Mustelus mustelus) as a starting biological material to characterize the digestive lipid hydrolyzing enzyme. A smooth-hound digestive lipase (SmDL) was purified from a delipidated pancreatic powder. The SmDL molecular weight was around 50kDa. Specific activities of 2200 and 500U/mg were measured at pH 9 and 40°C using tributyrin and olive oil emulsion as substrates, respectively. Unlike known mammal pancreatic lipases, the SmDL was stable at 50°C and it retained 90% of its initial activity after 15min of incubation at 60°C...
May 3, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28472908/targeted-nanostructured-lipid-carriers-for-delivery-of-paclitaxel-to-cancer-cells-preparation-characterization-and-cell-toxicity
#16
Mahboubeh Rezazadeh, Jaber Emami, Farshid Hassanzadeh, Hojjat Sadeghi, Mahboubeh Rostami, Hamid Mohammadkhani
Low water solubility, high systemic toxicity and insignificant cellular uptake has limited efficient clinical applications of the anti-tumor agent paclitaxel (PTX). To overcome these limitations, a novel nanostructured lipid carrier (NLC) modified with folic acid (FA) and polyethylene glycol (PEG) was prepared by emulsion solvent evaporation method using cholesterol, α-tocopherol, lecithin and Poloxamer. A partial factorial design was applied to determine the appropriate levels of variables for optimized formulation...
May 3, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28471049/oil-bodies-extracted-from-high-fat-and-low-fat-soybeans-stability-and-composition-during-storage
#17
Qiu Ling Wang, Chun Li Cui, Lian Zhou Jiang, Yue Liu, Xin Ting Liang, Jun Cai Hou
Soybeans contain oil bodies (OBs) that encapsulate triacylglycerols (TAGs) with a phospholipid monolayer carrying scattered proteins. In nature, soybean OBs can form natural emulsions in aqueous media and may serve as natural, minimally processed, stable, and pre-emulsified oil for addition into appropriate food systems. In this study, OBs were obtained by aqueous extraction from the mature seeds of 2 soybean crop cultivars, high-fat soybean and low-fat soybeans. The compositions of the extracted OBs were analyzed during storage at room temperature up to 14 d (pH = 7)...
May 4, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28471000/encapsulation-of-ritonavir-in-solid-lipid-nanoparticles-in-vitro-anti-hiv-1-activity-using-lentiviral-particles
#18
Farzaneh Javan, Alireza Vatanara, Kayhan Azadmanesh, Mohsen Nabi-Meibodi, Mehdi Shakouri
OBJECTIVES: In this study, ritonavir was entrapped into solid lipid nanoparticles (SLNs) employing two production methods. The prepared SLNs were characterized and antiretroviral activity was investigated for more efficient formulation. METHODS: Ritonavir-loaded SLNs were produced by solvent emulsification evaporation (SE) and double emulsion methods (DE), and the effects of Tween80 and poloxamer188 as external phase surfactant were compared. Prepared SLNs were characterized in terms of size, surface charge, entrapment efficiency (EE), release profile and thermal behaviour...
May 4, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28468891/the-effect-of-lipids-a-lipid-rich-ready-to-use-therapeutic-food-or-a-phytase-on-iron-absorption-from-maize-based-meals-fortified-with-micronutrient-powders
#19
Arnaud Monnard, Diego Moretti, Christophe Zeder, Andreas Steingötter, Michael B Zimmermann
Background: Ready-to-use-therapeutic foods (RUTFs) high in lipid, protein, and iron are used to treat malnutrition. Lipids increase gastric residence time, which could increase iron absorption, particularly from poorly soluble iron compounds and in combination with phytase.Objectives: The objectives were to 1) assess the effect on iron absorption of a lipid emulsion given 20 min before or together with an iron-fortified maize meal and 2) assess iron absorption from a micronutrient powder (MNP) given with a nutrient-dense RUTF and/or a microbial phytase...
May 3, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28467236/letter-in-response-to-lipid-emulsion-improves-survival-in-animal-models-of-local-anesthetic-toxicity-a-meta-analysis
#20
Lotte C G Hoegberg, Robert S Hoffman, Bryan D Hayes, Valéry Lavergne, Sophie Gosselin
No abstract text is available yet for this article.
May 3, 2017: Clinical Toxicology
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