keyword
https://read.qxmd.com/read/38529852/parenteral-nutrition-emulsion-inhibits-cyp3a4-in-an-ipsc-derived-liver-organoids-testing-platform
#1
JOURNAL ARTICLE
Sean P Harrison, Saphira F Baumgarten, Maria E Chollet, Benedicte Stavik, Anindita Bhattacharya, Runar Almaas, Gareth J Sullivan
OBJECTIVES: Parenteral nutrition (PN) is used for patients of varying ages with intestinal failure to supplement calories. Premature newborns with low birth weight are at a high risk for developing PN associated liver disease (PNALD) including steatosis, cholestasis, and gallbladder sludge/stones. To optimize nutrition regimens, models are required to predict PNALD. METHODS: We have exploited induced pluripotent stem cell derived liver organoids to provide a testing platform for PNALD...
March 26, 2024: Journal of Pediatric Gastroenterology and Nutrition
https://read.qxmd.com/read/38527076/parenteral-nutrition-at-home-long-term-parenteral-nutrition
#2
JOURNAL ARTICLE
Vanessa J Kumpf, Brenda Gray, Jessica Monczka, Sarah Zeraschi, Stanislaw Klek
DISCLAIMER: In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time. PURPOSE: Some diseases require that patients receive parenteral nutrition (PN) over a prolonged time period...
March 25, 2024: American Journal of Health-system Pharmacy: AJHP
https://read.qxmd.com/read/38524567/encapsulation-and-release-of-calcein-from-herceptin-conjugated-eliposomes
#3
JOURNAL ARTICLE
Mah Noor Zafar, William G Pitt, Ghaleb A Husseini
Achieving an optimal therapeutic level is crucial in effectively eradicating cancer cells during treatment. However, conventional chemotherapy-associated systemic administration of anticancer agents leads to many side effects. To achieve the desired control over the target site, active targeting of HER2-positive breast cancer cells can be achieved by conjugating liposomal vesicles with Human Epidermal growth factor Receptor 2 (HER2) and inducing release of the encapsulated drug using ultrasound. To further enhance the delivery efficiency, nanoemulsion droplets exhibiting responsiveness to low-frequency ultrasound are encapsulated within these lipid vesicles...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38523381/effect-of-intravenous-lipid-therapy-in-critically-ill-pediatric-patients-with-calcium-channel-blocker-toxicity
#4
JOURNAL ARTICLE
Sinan Yavuz, Ali Avcı, Rabia Gündoğan Serin, Mustafa Mesut Kaya, Dilfuza Ağalıoğlu
BACKGROUND: Overdose with calcium-channel blockers (CCBs) still maintain their importance with a high lethality rate after exposure. We report the intravenous lipid emulsion therapy (ILE) therapy in our CCB overdose patients. METHODS: We retrospectively analyzed the records of 6 patients with CCB intoxication from Batman Training and Research Hospital PICU between March 2021 and September 2022. Patients aged 0-18 years who received ILE treatment for CCB poisoning were included...
2024: Turkish Journal of Pediatrics
https://read.qxmd.com/read/38522289/recent-advances-in-studying-crystallisation-of-mono-and-di-glycerides-at-oil-water-interfaces
#5
JOURNAL ARTICLE
Stephanie V MacWilliams, Andrew J Clulow, Graeme Gillies, David A Beattie, Marta Krasowska
This review focuses on the current understanding regarding lipid crystallisation at oil-water interfaces. The main aspects of crystallisation in bulk lipids will be introduced, allowing for a more comprehensive overview of the crystallisation processes within emulsions. Additionally, the properties of an emulsion and the impact of lipid crystallisation on emulsion stability will be discussed. The effect of different emulsifiers on lipid crystallisation at oil-water interfaces will also be reviewed, however, this will be limited to their impact on the interfacial crystallisation of monoglycerides and diglycerides...
March 21, 2024: Advances in Colloid and Interface Science
https://read.qxmd.com/read/38518949/enhancing-the-stability-of-mung-bean-based-milk-insights-from-protein-characteristics-and-raw-material-selection
#6
JOURNAL ARTICLE
Ying Dai, Chunhong Li, Jinqi Liu, Lina Xing, Tong Zhu, Shuangneng Liu, Zheng Yan, Xiaowei Zheng, Li Wang, Jing Lu, Sumei Zhou
Plant-based milk (PBM) alternatives are gaining popularity worldwide as the change of consumers' nutritional habits and health attitudes. Mung beans, recognized for their nutritional value, have gained attention as potential ingredients for PBM. Nevertheless, mung bean-based milk (MBM) faces instability issues common to other plant-based milks. This study investigated the factors influencing MBM stability focusing on raw materials. We selected 6 out of 20 varieties based on their MBM centrifugation sedimentation rates, representing both stable and unstable MBM...
March 20, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38501019/nanoparticle-based-formulation-of-dihydroartemisinin-lumefantrine-duo-drugs-preclinical-evaluation-and-enhanced-antimalarial-efficacy-in-a-mouse-model
#7
JOURNAL ARTICLE
Pesila Akeyo Odera, Geoffrey Otieno, Joab Otieno Onyango, James Jorum Owuor, Florence Anyango Oloo, Martin Ongas, Jeremiah Gathirwa, Bernhards Ogutu
Artemisinin-based combinations (ACTs) are World Health Organization-recommended treatment for malaria. Artemether (A) and lumefantrine (LUM) were the first co-formulated ACT and first-line treatment for malaria globally, artemether is dihydroartemisinin's (DHA's) prodrug. Artemisinins and LUM face low aqueous solubility while artemisinin has low bioavailability and short half-life thus requiring continuous dosage to maintain adequate therapeutic drug-plasma concentration. This study aimed at improving ACTs limitations by nano-formulating DHA-LUM using solid lipid nanoparticles (SLNs) as nanocarrier...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38497659/brain-autopsy-findings-in-a-patient-who-received-lipid-emulsion-therapy-for-suspected-drug-intoxication
#8
JOURNAL ARTICLE
Hannah Cutshall, Murat Gokden
Lipid emulsion therapy (LET) is the intravenous administration of lipid solution for parenteral alimentation, especially in preterm infants and adults with debilitating illnesses. It has also been used in attempts of detoxification in suspected cases of drug overdose. Whether this interferes with circulation and/or perfusion is debatable, and it is suggested that it may interfere with coagulation process. The emulsifying agent has been identified microscopically mainly in the lungs of these patients, with rare reports in adults and even more rare ones in the brain; however, although it is rarely reported in other organs, to our knowledge, no reports of gross autopsy findings in the brain are available in the English literature, nor are there reports of pathologic findings after lipid emulsion therapy administration for drug toxicity...
March 18, 2024: American Journal of Forensic Medicine and Pathology
https://read.qxmd.com/read/38489714/lipid-emulsion-treatment-for-local-anesthetic-systemic-toxicity-in-pediatric-patients-a-systematic-review
#9
JOURNAL ARTICLE
Soo Hee Lee, Sunmin Kim, Ju-Tae Sohn
BACKGROUND: Local anesthetic systemic toxicity (LAST) is rare, but fatal; the current widely used treatment is lipid emulsion (LE). The goal of this study was to analyze and review case reports on LE treatment for LAST in pediatric patients. METHODS: We performed a systematic review using case reports on LE treatment for LAST in pediatric patients, searching PubMed and Scopus databases to March 2023 using the following keywords: ("local anesthetic toxicity" OR "local anesthetic systemic toxicity" OR LAST") AND ("newborn" OR "infant" OR "child" OR "children" OR "adolescent" OR "pediatric") AND ("lipid emulsion" OR "Intralipid")...
March 15, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38489675/effect-of-lipid-emulsion-on-neuropsychiatric-drug-induced-toxicity-a-narrative-review
#10
REVIEW
Yeran Hwang, Ju-Tae Sohn
Lipid emulsion has been shown to effectively relieve refractory cardiovascular collapse resulting from toxic levels of nonlocal anesthetics. The goal of this study was to examine the effect of lipid emulsions on neuropsychiatric drug-induced toxicity using relevant case reports of human patients, with a particular focus on the Glasgow Coma Scale (GCS) score and corrected QT interval, to analyze drugs that frequently require lipid emulsion treatment. The following keywords were used to retrieve relevant case reports from PubMed: "antidepressant or antipsychotic drug or amitriptyline or bupropion or citalopram or desipramine or dosulepin or dothiepin or doxepin or escitalopram or fluoxetine or haloperidol or olanzapine or phenothiazine or quetiapine or risperidone or trazodone" and "lipid emulsion or Intralipid...
March 15, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38488429/the-lipid-intensive-drug-therapy-for-sepsis-phase-ii-pilot-clinical-trial
#11
JOURNAL ARTICLE
Faheem W Guirgis, Lauren Page Black, Morgan Henson, Andrew Bertrand, Elizabeth DeVos, Jason Ferreira, Hanzhi Gao, Samuel S Wu, Christiaan Leeuwenburgh, Lyle Moldawer, Frederick Moore, Srinivasa T Reddy
OBJECTIVES: Low cholesterol levels in early sepsis patients are associated with mortality. We sought to test if IV lipid emulsion administration to sepsis patients with low cholesterol levels would prevent a decline or increase total cholesterol levels at 48 hours. DESIGN: Phase II, adaptive, randomized pilot clinical trial powered for 48 patients. SETTING: Emergency department or ICU of an academic medical center. PATIENTS: Sepsis patients (first 24 hr) with Sequential Organ Failure Assessment greater than or equal to 4 or shock...
March 15, 2024: Critical Care Medicine
https://read.qxmd.com/read/38478757/development-of-crystalline-corneal-opacities-steroid-keratopathy-in-dogs-after-treatment-with-ophthalmic-corticosteroids
#12
JOURNAL ARTICLE
Katelin R Quantz, Kamontip K Jongnarangsin, Christine D Harman, Kristin L Koehl, Amanda L Jacobson, Nambi Nallasamy, Gillian C Shaw, Christopher G Pirie, András M Komáromy
PURPOSE: To retrospectively evaluate and describe the relationship between the use of topical corticosteroids and the development of crystalline corneal opacities (steroid keratopathy) in a colony of research Beagles and Beagle-derived dogs. METHODS: Medical records of 73 purpose-bred Beagles and Beagle-derived dogs were reviewed from June 2012 to May 2021. All dogs were treated with topical ophthalmic corticosteroids for at least 21 days. In addition to regular ophthalmic examination, some dogs also had a systemic lipid profile (n = 6) performed to work up further and characterize the crystalline corneal opacities...
March 13, 2024: Cornea
https://read.qxmd.com/read/38476917/modulation-of-secretory-factors-by-lipofundin-contributes-to-its-anti%C3%A2-neuroinflammatory-effects
#13
JOURNAL ARTICLE
Ming-Shan Chen, Chia-Lin Hu, Shin-Kuang Jiang, Zhi-Yong Chong, Jui-Chieh Chen
As the global population ages, the prevalence of neuroinflammatory diseases such as Alzheimer's disease, Parkinson's disease and stroke continues to increase. Therefore, it is necessary to develop preventive and therapeutic methods against neuroinflammatory diseases. Lipofundin is a lipid emulsion commonly used in clinical anesthetic solvents and nutritional supplements. Lipid emulsions have been shown to possess anti-inflammatory properties. However, the potential beneficial effect of lipofundin against neuroinflammation requires elucidation...
April 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38474716/structure-biological-functions-separation-properties-and-potential-applications-of-milk-fat-globule-membrane-mfgm-a-review
#14
REVIEW
Chao Nie, Yunyi Zhao, Xifan Wang, Yixuan Li, Bing Fang, Ran Wang, Xiaoyu Wang, Haiping Liao, Gengsheng Li, Pengjie Wang, Rong Liu
BACKGROUND: The milk fat globule membrane (MFGM) is a thin film that exists within the milk emulsion, suspended on the surface of milk fat globules, and comprises a diverse array of bioactive components. Recent advancements in MFGM research have sparked a growing interest in its biological characteristics and health-related functions. Thorough exploration and utilization of MFGM as a significant bioactive constituent in milk emulsion can profoundly impact human health in a positive manner...
February 21, 2024: Nutrients
https://read.qxmd.com/read/38472901/the-effects-of-sunflower-and-maize-crop-residue-extracts-as-a-new-ingredient-on-the-quality-properties-of-pork-liver-p%C3%A3-t%C3%A3-s
#15
JOURNAL ARTICLE
Milica Glišić, Marija Bošković Cabrol, Nikola Čobanović, Marija Starčević, Stevan Samardžić, Ivona Veličković, Zoran Maksimović
The present study aimed to evaluate the antioxidant capacity of ethanolic extracts from post-harvest sunflower and maize stalk residues, and their impact on the chemical composition, physicochemical parameters, lipid oxidative stability, microbiological properties, and sensory characteristics of pork liver pâtés over a 90-day storage period. Four formulations were prepared: a control group (CON), a batch with butylated hydroxytoluene as a synthetic antioxidant (BHT), 1% ethanolic extract from sunflower residues (SSRE), and 1% ethanolic extract from maize residues (MSRE)...
March 3, 2024: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38472842/new-insight-into-food-grade-emulsions-candelilla-wax-based-oleogels-as-an-internal-phase-of-novel-vegan-creams
#16
JOURNAL ARTICLE
Iwona Szymanska, Anna Zbikowska, Sylwia Onacik-Gür
Cream-type emulsions containing candelilla wax-based oleogels (EC) were analyzed for their physicochemical properties compared to palm oil-based creams (EP). The microstructure, rheological behavior, stability, and color of the creams were determined by means of non-invasive and invasive techniques. All the formulations exhibited similar color parameters in CIEL*a*b* space, unimodal-like size distribution of lipid particles, and shear-thinning properties. Oleogel-based formulations were characterized by higher viscosity (consistency index: 172-305 mPa·s, macroscopic viscosity index: 2...
February 28, 2024: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38472788/effect-of-addition-of-mango-seed-extract-on-storage-stability-of-chevon-meatballs-at-refrigeration-temperature
#17
JOURNAL ARTICLE
Pramila Umaraw, Veer Pal Singh, Akhilesh K Verma
In this study, the addition of mango seed extract (MSE) in goat meatballs was assessed. The efficacy of three different levels of MSE extract, namely T1 = (2.5 mL/100 g of meat emulsion v / w ), T2 = (5.0 mL/100 g of meat emulsion v / w ), T3 = (7.5 mL/100 g of meat emulsion v / w ), and T0 (control without mango seed extract), was conducted for evaluation of changes in water activity (aW ), pH, total phenolic compounds, DPPH, peroxide value, TBARS, microbial quality, and sensory attributes of the goat meatballs stored at refrigerated temperature (4 ± 1 °C)...
February 23, 2024: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38458540/broad-antibody-and-t-cell-responses-to-ebola-sudan-and-bundibugyo-ebolaviruses-using-mono-and-multi-valent-adjuvanted-glycoprotein-vaccines
#18
JOURNAL ARTICLE
Jiin Felgner, Elizabeth Clarke, Jenny E Hernandez-Davies, Sharon Jan, Ariel Wirchnianski, Aarti Jain, Rie Nakajima, Algimantas Jasinskas, Erwin Strahsberger, Kartik Chandran, Steven Bradfute, D Huw Davies
Currently, there are two approved vaccine regimens designed to prevent Ebola virus (EBOV) disease (EVD). Both are virus-vectored, and concerns about cold-chain storage and pre-existing immunity to the vectors warrant investigating additional vaccine strategies. Here, we have explored the utility of adjuvanted recombinant glycoproteins (GPs) from ebolaviruses Zaire (EBOV), Sudan (SUDV), and Bundibugyo (BDBV) for inducing antibody (Ab) and T cell cross-reactivity. Glycoproteins expressed in insect cells were administered to C57BL/6 mice as free protein or bound to the surface of liposomes, and formulated with toll-like receptor agonists CpG and MPLA (agonists for TLR 9 and 4, respectively), with or without the emulsions AddaVax or TiterMax...
March 6, 2024: Antiviral Research
https://read.qxmd.com/read/38458131/comparison-of-the-physical-stability-microstructure-and-protein-lipid-co-oxidation-of-o-w-emulsions-stabilized-by-l-arginine-l-lysine-modified-soy-protein-hydrolysate
#19
JOURNAL ARTICLE
Bin Zhu, Jinjie Yang, Jingjing Dou, Yijie Ning, Baokun Qi, Yang Li
This work investigated the physical stability, microstructure, and oxidative stability of the emulsions prepared by soy protein hydrolysate (SPH) after modification with different concentrations of l-arginine and l-lysine. l-Arginine and l-lysine significantly increased the absolute zeta potential values, and decreased droplet sizes of the emulsions, thereby improving the physical stability of the emulsions. Meanwhile, l-arginine and l-lysine markedly decreased the apparent viscosity of the emulsions. The measurement of interfacial protein adsorption percentage showed that l-arginine (≤0...
March 6, 2024: Food Chemistry
https://read.qxmd.com/read/38451395/anti-rheumatoid-arthritis-potential-of-halodule-pinifolia-development-characterization-and-in-vivo-evaluation-of-h-pinifolia-based-oral-suspension-and-lipid-nano-emulsion
#20
JOURNAL ARTICLE
Samun Nessa, S Lavanya, Rajesh K Routray, Akash Chaurasiya, Onkar P Kulkarni, A Sajeli Begum
For treating chronic diseases like rheumatoid arthritis, herbal medicines are preferred due to their evident therapeutic effects and lesser side effects as compared to the long-term used conventional drugs. In this study, the anti-rheumatoid arthritis effect of an unexplored marine grass Halodule pinifolia (HP), and a combination of it with Glycyrrhiza glabra (liquorice; LQ), prepared as a conventional suspension (C1) and a lipid nano-emulsion (C1-N) was evaluated in Freund's complete adjuvant (FCA)- and collagen-induced arthritis (CIA) models...
March 7, 2024: Inflammopharmacology
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