Sergio Mezzano, Claudio Aros, Alejandra Droguett, M Eugenia Burgos, Leopoldo Ardiles, Claudio Flores, Herman Schneider, Marta Ruiz-Ortega, Jesús Egido
BACKGROUND: Nuclear factor-kappaB (NF-kappaB) regulates genes involved in renal disease progression, such as the chemokines monocyte chemoattractant protein-1 (MCP-1) and RANTES. NF-kappaB is activated in experimental models of renal injury, and in vitro studies also suggest that proteinuria and angiotensin II could be important NF-kappaB activators. It has been proposed that locally produced MCP-1 may be involved in the development of diabetic nephropathy (DN). We examined the hypothesis that NF-kappaB could be an indicator of renal damage progression in DN...
October 2004: Nephrology, Dialysis, Transplantation