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Global ophthalmology

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https://www.readbyqxmd.com/read/28623165/ocular-effects-of-zika-virus-a-review
#1
REVIEW
Maria Carolina Marquezan, Camila V Ventura, Jeanne S Sheffield, William Christopher Golden, Revaz Omiadze, Rubens Belfort, William May
Zika virus (ZIKV) was considered an innocent pathogen while restricted to the African and Asian population; however, after reaching the Americas in March 2015, it became a global threat. Despite usually causing mild or no symptoms in infected adults, ZIKV displays a different behavior towards fetuses. When infected during gestation, fetuses have their immature neural cells killed by the virus and consequently have devastating findings at birth. In the past year, the drastic effects of ZIKV infection in newborns include neurological, ophthalmological, audiological, and skeletal abnormalities...
June 13, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28607759/a-composite-measure-to-explore-visual-disability-in-primary-progressive-multiple-sclerosis
#2
Valentina Poretto, Maria Petracca, Catarina Saiote, Enricomaria Mormina, Jonathan Howard, Aaron Miller, Fred D Lublin, Matilde Inglese
BACKGROUND: Optical coherence tomography (OCT) and magnetic resonance imaging (MRI) can provide complementary information on visual system damage in multiple sclerosis (MS). OBJECTIVES: The objective of this paper is to determine whether a composite OCT/MRI score, reflecting cumulative damage along the entire visual pathway, can predict visual deficits in primary progressive multiple sclerosis (PPMS). METHODS: Twenty-five PPMS patients and 20 age-matched controls underwent neuro-ophthalmologic evaluation, spectral-domain OCT, and 3T brain MRI...
April 2017: Multiple Sclerosis Journal—Experimental, Translational and Clinical
https://www.readbyqxmd.com/read/28584935/evaluation-of-optic-nerve-head-parameters-and-retinal-nerve-fiber-layer-thickness-in-axial-myopia-using-sd-oct
#3
Heba Radi AttaAllah, Ismail Ahmed Nagib Omar, Ahmed Shawkat Abdelhalim
INTRODUCTION: The purpose of this research was to study the effect of increased axial myopia, in non-glaucomatous eyes, and its correlation with ONH parameters, and RNFL thickness, using Cirrus HD 4000 SD-OCT. METHODS: The myopia group included 86 eyes of 86 patients, while the control group involved 92 eyes of 92 patients, attending the Ophthalmology Outpatient Clinic in Minia University Hospital, between November 2013 and March 2015. ONH parameters and peripapillary RNFL thickness measurement were evaluated by using SD-OCT, selecting the standard optic disc cube 200 × 200...
June 5, 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28549094/a-novel-dominant-mutation-in-sag-the-arrestin-1-gene-is-a-common-cause-of-retinitis-pigmentosa-in-hispanic-families-in-the-southwestern-united-states
#4
Lori S Sullivan, Sara J Bowne, Daniel C Koboldt, Elizabeth L Cadena, John R Heckenlively, Kari E Branham, Dianna H Wheaton, Kaylie D Jones, Richard S Ruiz, Mark E Pennesi, Paul Yang, David Davis-Boozer, Hope Northrup, Vsevold V Gurevich, Rui Chen, Mingchu Xu, Yumei Li, David G Birch, Stephen P Daiger
Purpose: To identify the causes of autosomal dominant retinitis pigmentosa (adRP) in a cohort of families without mutations in known adRP genes and consequently to characterize a novel dominant-acting missense mutation in SAG. Methods: Patients underwent ophthalmologic testing and were screened for mutations using targeted-capture and whole-exome next-generation sequencing. Confirmation and additional screening were done by Sanger sequencing. Haplotypes segregating with the mutation were determined using short tandem repeat and single nucleotide variant polymorphisms...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28549018/intimate-partner-violence-in-ophthalmology-a-global-call-to-action
#5
Ali R Cohen, Lynette M Renner, Erin M Shriver
PURPOSE OF REVIEW: Intimate partner violence (IPV) is a leading cause of death and disability worldwide. Despite increasing public awareness of IPV, little information is available regarding the prevalence, associated injury patterns, and impact of IPV as a mechanism of ocular and orbital trauma. The purpose of this review is to summarize the literature regarding the impact of IPV in ophthalmology and provide team members with guidance on appropriate practices for screening and referral...
April 25, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28438271/how-does-an-inventor-find-an-investor-or-partner-raising-funds-to-start-a-company
#6
Rudy A Mazzocchi
Rudy Mazzocchi has over 25 years of senior executive management, technology and intellectual property development, and financing experience in the medical-technology/biotechnology industries. He serves currently as cofounder/chief executive officer of ELENZA, Inc, an ophthalmology company that has developed an electro-active, autofocusing, implantable lens; executive chairman of Establishment Labs; executive chairman of LAFORGE Optical; and executive chairman of OptiSTENT, Inc. He served previously as managing director of Accuitive Medical Ventures and The Innovation Factory; cofounder/chief executive officer of Image-Guided NEUROLOGICS, acquired by Medtronic in 2005; and founding chief executive officer of MICROVENA Corporation, which became "eV3," acquired by Covidien...
May 2017: Surgery
https://www.readbyqxmd.com/read/28434885/early-performance-on-an-eye-surgery-simulator-predicts-subsequent-resident-surgical-performance
#7
Ramak Roohipoor, Mehdi Yaseri, Amir Teymourpour, Carolyn Kloek, John B Miller, John I Loewenstein
OBJECTIVE: To examine early performance on an eye surgery simulator and its relationship to subsequent live surgical performance in a single large residency program. DESIGN: Retrospective study. SETTING: Massachusetts Eye and Ear, Harvard Medical School, Department of Ophthalmology. METHODS: In a retrospective study, we compared performance of 30 first-year ophthalmology residents on an eye surgery simulator to their surgical skills as third-year residents...
April 20, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28393035/retinal-ganglion-cell-complex-changes-using-spectral-domain-optical-coherence-tomography-in-diabetic-patients-without-retinopathy
#8
Ahmed I Hegazy, Rasha H Zedan, Tamer A Macky, Soheir M Esmat
AIM: To assess the ganglion cell complex (GCC) thickness in diabetic eyes without retinopathy. METHODS: Two groups included 45 diabetic eyes without retinopathy and 21 non diabetic eyes. All subjects underwent full medical and ophthalmological history, full ophthalmological examination, measuring GCC thickness and central foveal thickness (CFT) using the RTVue(®) spectral domain-optical coherence tomography (SD-OCT), and HbA1C level. RESULTS: GCC focal loss volume (FLV%) was significantly more in diabetic eyes (22...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28384377/implantation-of-two-second-generation-trabecular-micro-bypass-stents-and-topical-travoprost-in-open-angle-glaucoma-not-controlled-on-two-preoperative-medications-18-month-follow-up
#9
John Berdahl, Lilit Voskanyan, Jonathan S Myers, Dana M Hornbeak, Jane Ellen Giamporcaro, L Jay Katz, Thomas W Samuelson
IMPORTANCE: Additional data are sought regarding treatment options for glaucoma, a major cause of global blindness. BACKGROUND: The study assessed outcomes following standalone implantation of 2 second-generation trabecular micro-bypass stents and postoperative topical prostaglandin in eyes with open-angle glaucoma (OAG) not controlled on 2 preoperative medications. DESIGN: Prospective, nonrandomized, open-label study at a tertiary-care ophthalmology centre...
April 6, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28341010/history-and-development-of-ophthalmology-in-taiwan
#10
REVIEW
Yu-Chih Hou, Gale A Oren, Muh-Shy Chen, Fung-Rong Hu
Western medicine was first introduced to Taiwan by medical missionaries in the mid-19(th) century. Modernization of medicine was systematically transplanted to Taiwan in the Japanese colonial period, and ophthalmology was established third among hospital departments, following internal medicine and surgery. Dr Hidetaka Yamaguchi, an ophthalmologist, was the first head of the Taihoku Hospital, later known as National Taiwan University Hospital (NTUH; Taipei, Taiwan). Ophthalmologists during the colonial period conducted studies on tropical and infectious eye diseases...
December 2016: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28301340/microperimetry-in-best-vitelliform-macular-dystrophy
#11
Maurizio Battaglia Parodi, Niccolò Castellino, Pierluigi Iacono, Itay Chowers, Theodoros Empeslidis, Michaella Goldstein, Francesco Bandello
PURPOSE: To investigate retinal sensitivity in eyes with all the clinical stages of Best vitelliform macular dystrophy (VMD). METHODS: Thirty-two patients affected by VMD in subclinical, vitelliform, pseudohypopyon, vitelliruptive, and atrophic stages were enrolled in this prospective cross-sectional study. Patients underwent a complete ophthalmologic examination, including determination of best-corrected visual acuity (BCVA), staging of the disease (Gass's classification), and microperimetry by means of the macular integrity assessment microperimeter...
March 15, 2017: Retina
https://www.readbyqxmd.com/read/28260359/-study-of-retinal-microvascular-perfusion-alteration-and-structural-damage-at-macular-region-in-primary-open-angle-glaucoma-patients
#12
H Xu, X M Kong
Objective: To investigate the alteration of retinal microcirculation and structural damage at macular region and evaluate their associations in primary open angle glaucoma (POAG) eyes. Methods: Cross-sectional study. Fifty-nine POAG patients (male/femal=35/24) were recruited from July 2015 to December 2015 in Eye, Ear, Nose and Throat Hospital of Fudan University. Twenty-eight eyes of early-stage POAG group (EG), 11 eyes of moderate-stage POAG group (MG) and 20 eyes of severe-stage POAG group (SG) were enrolled in this study...
February 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28212157/current-approaches-to-myopia-control
#13
REVIEW
Seo Wei Leo
PURPOSE OF REVIEW: Myopia is a global problem, being particularly prevalent in the urban areas of east and southeast Asia. In addition to the direct economic and social burdens, associated ocular complications may lead to substantial vision loss. With prevalence of myopia above 80% and high myopia over 20%, it is crucial to control myopia. The aim of this review to is provide an update on the interventions to slow the onset of myopia and retard its progression. RECENT FINDINGS: The epidemic of myopia is characterized by increasingly early onset, combined with high myopia progression rates...
May 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28161930/electronic-referrals-and-digital-imaging-systems-in-ophthalmology-a-global-perspective
#14
V Swetha E Jeganathan, H Nikki Hall, Roshini Sanders
Ophthalmology departments face intensifying pressure to expedite sight-saving treatments and reduce the global burden of disease. The use of electronic communication systems, digital imaging, and redesigned service care models is imperative for addressing such demands. The recently developed Scottish Eyecare Integration Project involves an electronic referral system from community optometry to the hospital ophthalmology department using National Health Service (NHS) email with digital ophthalmic images attached, via a virtual private network connection...
January 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28145974/quantitative-analysis-of-optical-coherence-tomography-angiography-in-adult-onset-foveomacular-vitelliform-dystrophy
#15
Maurizio Battaglia Parodi, Alessandro Rabiolo, Maria Vittoria Cicinelli, Pierluigi Iacono, Francesco Romano, Francesco Bandello
PURPOSE: To quantify the foveal avascular zone area at superficial capillary plexus (SCP) and deep capillary plexus (DCP) and the global, parafoveal, and perifoveal vessel densities at SCP, DCP, and choriocapillaris using optical coherence tomography angiography in patients affected by adult-onset foveomacular vitelliform dystrophy (AOFVD). METHODS: Twenty eyes of 20 consecutive patients (10 females, 50%) with AOFVD and 20 eyes of 20 healthy controls presenting at the Department of Ophthalmology of San Raffaele Hospital, Milan, Italy were enrolled...
January 31, 2017: Retina
https://www.readbyqxmd.com/read/28113480/accurate-joint-alignment-of-indocyanine-green-and-fluorescein-angiograph-sequences-for-treatment-of-subretinal-lesions
#16
Chia-Ling Tsai, Hung-Chuan Hsu, Xin-Chang Wu, Shih-Jen Chen, Wei-Yang Lin
In ophthalmology, aligning images in Indocyanine Green (ICG) and Fluorescein Angiograph (FA) sequences is important for the treatment of subretinal lesions. This paper introduces an algorithm which is tailored to align jointly in a common reference space all the images in an angiogram sequence containing both modalities. To overcome the issues of low image contrast and low signal-to-noise ratio for late-phase images, the structural similarity between two images is enhanced using Gabor Wavelet Transform. Image pairs are pairwise-registered and the transformations are simultaneously and globally adjusted for a mutually consistent joint alignment...
March 4, 2016: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28018441/a-neonate-with-joubert-syndrome-presenting-with-symptoms-of-horner-syndrome
#17
Narae Lee, Sang-Ook Nam, Young Mi Kim, Yun-Jin Lee
Joubert syndrome (JS) is characterized by the "molar tooth sign" (MTS) with cerebellar vermis agenesis, episodic hyperpnea, abnormal eye movements, and hypotonia. Ocular and oculomotor abnormalities have been observed; however, Horner syndrome (HS) has not been documented in children with JS. We present the case of a 2-month-old boy having ocular abnormalities with bilateral nystagmus, left-dominant bilateral ptosis, and unilateral miosis and enophthalmos of the left eye, which were compatible with HS. Brain magnetic resonance imaging (MRI) revealed the presence of the MTS...
November 2016: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/28009240/venous-sinus-stenting-for-reduction-of-intracranial-pressure-in-iih-a-prospective-pilot-study
#18
Kenneth C Liu, Robert M Starke, Christopher R Durst, Tony R Wang, Dale Ding, R Webster Crowley, Steven A Newman
OBJECTIVE Idiopathic intracranial hypertension (IIH) may cause blindness due to elevated intracranial pressure (ICP). Venous sinus stenosis has been identified in select patients, leading to stenting as a potential treatment, but its effects on global ICP have not been completely defined. The purpose of this pilot study was to assess the effects of venous sinus stenting on ICP in a small group of patients with IIH. METHODS Ten patients for whom medical therapy had failed were prospectively followed. Ophthalmological examinations were assessed, and patients with venous sinus stenosis on MR angiography proceeded to catheter angiography, venography with assessment of pressure gradient, and ICP monitoring...
December 23, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27937751/failure-to-integrate-quantitative-measurement-methods-of-ocular-inflammation-hampers-clinical-practice-and-trials-on-new-therapies-for-posterior-uveitis
#19
Carl P Herbort, Ilknur Tugal-Tutkun, Piergiorgio Neri, Carlos Pavésio, Sumru Onal, Phuc LeHoang
Uveitis is one of the fields in ophthalmology where a tremendous evolution took place in the past 25 years. Not only did we gain access to more efficient, more targeted, and better tolerated therapies, but also in parallel precise and quantitative measurement methods developed allowing the clinician to evaluate these therapies and adjust therapeutic intervention with a high degree of precision. Objective and quantitative measurement of the global level of intraocular inflammation became possible for most inflammatory diseases with direct or spill-over anterior chamber inflammation, thanks to laser flare photometry...
May 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27916860/novel-pigt-variant-in-two-brothers-expansion-of-the-multiple-congenital-anomalies-hypotonia-seizures-syndrome-3-phenotype
#20
Nadia Skauli, Sean Wallace, Samuel C C Chiang, Tuva Barøy, Asbjørn Holmgren, Asbjørg Stray-Pedersen, Yenan T Bryceson, Petter Strømme, Eirik Frengen, Doriana Misceo
Biallelic PIGT variants were previously reported in seven patients from three families with Multiple Congenital Anomalies-Hypotonia Seizures Syndrome 3 (MCAHS3), characterized by epileptic encephalopathy, hypotonia, global developmental delay/intellectual disability, cerebral and cerebellar atrophy, craniofacial dysmorphisms, and skeletal, ophthalmological, cardiac, and genitourinary abnormalities. We report a novel homozygous PIGT missense variant c.1079G>T (p.Gly360Val) in two brothers with several of the typical features of MCAHS3, but in addition, pyramidal tract neurological signs...
November 29, 2016: Genes
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