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Global ophthalmology

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https://www.readbyqxmd.com/read/29369235/global-practice-patterns-in-the-management-of-infantile-cataracts
#1
Euna B Koo, Deborah K VanderVeen, Scott R Lambert
OBJECTIVES: Surveys are an important tool to assess the impact of research on physicians' approach to patient care. This survey was conducted to assess current practice patterns in the management of infantile cataracts in light of the findings of the Infant Aphakia Treatment Study. METHODS: Pediatric ophthalmologists were emailed a link to the survey using newsletters from American Association of Pediatric Ophthalmology and Strabismus, World Society of Pediatric Ophthalmology and Strabismus, and the Pediatric Listserv...
January 15, 2018: Eye & Contact Lens
https://www.readbyqxmd.com/read/29290337/kiaa1109-variants-are-associated-with-a-severe-disorder-of-brain-development-and-arthrogryposis
#2
Lucie Gueneau, Richard J Fish, Hanan E Shamseldin, Norine Voisin, Frédéric Tran Mau-Them, Egle Preiksaitiene, Glen R Monroe, Angeline Lai, Audrey Putoux, Fabienne Allias, Qamariya Ambusaidi, Laima Ambrozaityte, Loreta Cimbalistienė, Julien Delafontaine, Nicolas Guex, Mais Hashem, Wesam Kurdi, Saumya Shekhar Jamuar, Lim J Ying, Carine Bonnard, Tommaso Pippucci, Sylvain Pradervand, Bernd Roechert, Peter M van Hasselt, Michaël Wiederkehr, Caroline F Wright, Ioannis Xenarios, Gijs van Haaften, Charles Shaw-Smith, Erica M Schindewolf, Marguerite Neerman-Arbez, Damien Sanlaville, Gaëtan Lesca, Laurent Guibaud, Bruno Reversade, Jamel Chelly, Vaidutis Kučinskas, Fowzan S Alkuraya, Alexandre Reymond
Whole-exome and targeted sequencing of 13 individuals from 10 unrelated families with overlapping clinical manifestations identified loss-of-function and missense variants in KIAA1109 allowing delineation of an autosomal-recessive multi-system syndrome, which we suggest to name Alkuraya-Kučinskas syndrome (MIM 617822). Shared phenotypic features representing the cardinal characteristics of this syndrome combine brain atrophy with clubfoot and arthrogryposis. Affected individuals present with cerebral parenchymal underdevelopment, ranging from major cerebral parenchymal thinning with lissencephalic aspect to moderate parenchymal rarefaction, severe to mild ventriculomegaly, cerebellar hypoplasia with brainstem dysgenesis, and cardiac and ophthalmologic anomalies, such as microphthalmia and cataract...
December 27, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29284445/mapping-standard-ophthalmic-outcome-sets-to-metrics-currently-reported-in-eight-eye-hospitals
#3
Monica Michelotti, Dirk F de Korne, Jennifer S Weizer, Paul P Lee, Declan Flanagan, Simon P Kelly, Anne Odergren, Sukhpal S Sandhu, Charity Wai, Niek Klazinga, Aravind Haripriya, Joshua D Stein, Melanie Hingorani
BACKGROUND: To determine alignment of proposed international standard outcomes sets for ophthalmic conditions to metrics currently reported by eye hospitals. METHODS: Mixed methods comparative benchmark study, including eight eye hospitals in Australia, India, Singapore, Sweden, U.K., and U.S. All are major international tertiary care and training centers in ophthalmology. Main outcome measure is consistency of ophthalmic outcomes measures reported. RESULTS: International agreed standard outcomes (ICHOM) sets are available for cataract surgery (10 metrics) and macular degeneration (7 metrics)...
December 29, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29279656/prevalence-and-major-causes-of-visual-impairment-in-iranian-adults-a-systematic-review
#4
Seyed-Farzad Mohammadi, Ghasem Saeedi-Anari, Elham Ashrafi, Seyed-Mehrdad Mohammadi, Farshad Farzadfar, Alireza Lashay, Hassan Hashemi
PURPOSE: The purpose of this study is to provide a pooled estimate of moderate-to-severe visual impairment (MSVI) and blindness in Iran for people 50 years and over and to identify the major causes through systematic review. MATERIALS AND METHODS: International (PubMed, ISI Web of Science, and Scopus) and national databases (Scientific Information Database, Barakat Knowledge Network System, Iran Databank of Ophthalmology Research, and Magiran) databases were searched...
July 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/29279073/characterization-of-all-surgical-specimens-provided-by-a-portuguese-department-of-ophthalmology-over-a-13-year-period
#5
José Ferreira Mendes, Ana Margarida Ferreira, Cristina Freitas
INTRODUCTION: We intend to evaluate clinically, topographically and morphologically all surgical specimens sent by the Department of Ophthalmology of Hospital de Braga to the Department of Pathology of the same hospital. MATERIAL AND METHODS: Two hundred and fifty eight surgically obtained specimens, from the Department of Ophthalmology of Hospital de Braga, analyzed in the Department of Pathology, from January 2002 to June 2015, were characterized. Data was arranged according to year, age, sex, topography and morphological diagnosis according to the SNOMED® coding system...
November 29, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/29260500/baseline-demographics-clinical-features-and-treatment-protocols-of-240-patients-with-optic-neuropathy-experiences-from-a-neuro-ophthalmological-clinic-in-the-aegean-region-of-turkey
#6
Omer Karti, Dilek Top Karti, İlay Hilal Kilic, Figen Gokcay, Nese Celebisoy
PURPOSE: To analyze the demographic patterns, clinical characteristics, and treatment protocols of optic neuropathies. MATERIALS AND METHODS: The hospital data of patients with optic neuropathy admitted to the Department of Neuro-ophthalmology in a tertiary referral center in Turkey between January 2010 to January 2017 were retrospectively analyzed. Demographic patterns, clinical features, treatment protocols, and the natural disease courses were assessed. RESULTS: The total number of patients with optic neuropathy seen over this period was 240, which consist of 43 with idiopathic optic neuritis (17...
December 19, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29259910/scientometric-analysis-of-published-papers-in-global-ophthalmology-in-the-past-ten-years
#7
Zheng-Lu Yu, Xin-Yue Hu, Ying-Na Wang, Zheng Ma
AIM: To investigate the published papers of ophthalmology in past ten years and explore the development of ophthalmology. METHORDS: The data of this study retrieved from Science Citation Index Expanded and downloaded online in November 2017, including all the papers with publication year from 2007-2016 were analyzed. The papers were based on the Web of Science category and the journals were based on the Journal Citation Report category. RESULTS: The number of ophthalmology papers increased from 7450 to 9089 during 2007 to 2017...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29241744/fragility-of-results-in-ophthalmology-randomized-controlled-trials-a-systematic-review
#8
REVIEW
Carl Shen, Isabel Shamsudeen, Forough Farrokhyar, Kourosh Sabri
PURPOSE: Evidence-based medicine is guided by our interpretation of randomized controlled trials (RCTs) that address important clinical questions. Evaluation of the robustness of statistically significant outcomes adds a crucial element to the global assessment of trial findings. The purpose of this systematic review was to determine the robustness of ophthalmology RCTs through application of the Fragility Index (FI), a novel metric of the robustness of statistically significant outcomes...
December 11, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29167629/the-effects-of-phacoemulsification-and-intraocular-lens-implantation-on-anatomical-and-functional-parameters-in-patients-with-primary-angle-closure-a-prospective-study-an-american-ophthalmological-society-thesis
#9
Carlo Enrico Traverso, Carlo Alberto Cutolo
Purpose: To investigate the clinical, anatomical, and patient-reported outcomes of phacoemulsification (PE) with intraocular lens implantation performed to treat primary angle closure (PAC) and primary angle-closure glaucoma (PACG). Methods: Patients were evaluated at baseline and at 6 months after PE. The examination included visual acuity, intraocular pressure (IOP), visual field, optic nerve head, endothelial cell count (ECC), aqueous depth, and ocular biometric parameters...
August 2017: Transactions of the American Ophthalmological Society
https://www.readbyqxmd.com/read/29160549/a-need-for-standardization-in-visual-acuity-measurement
#10
Hina Patel, Nathan Congdon, Glenn Strauss, Charles Lansingh
Standardization of terminologies and methods is increasingly important in all fields including ophthalmology, especially currently when research and new technology are rapidly driving improvements in medicine. This review highlights the range of notations used by vision care professionals around the world for vision measurement, and the challenges resulting from this practice. The global community is urged to move toward a uniform standard.
September 2017: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/29042759/early-and-intermediate-age-related-macular-degeneration-update-and-clinical-review
#11
REVIEW
Alfredo García-Layana, Francisco Cabrera-López, José García-Arumí, Lluís Arias-Barquet, José M Ruiz-Moreno
Age-related macular degeneration (AMD) is the leading cause of irreversible central vision loss in developed countries. With the aging of population, AMD will become globally an increasingly important and prevalent disease worldwide. It is a complex disease whose etiology is associated with both genetic and environmental risk factors. An extensive decline in the quality of life and progressive need of daily living assistance resulting from AMD among those most severely affected highlights the essential role of preventive strategies, particularly advising patients to quit smoking...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29037977/toxocariasis-in-humans-in-africa-a-systematic-review
#12
REVIEW
Felix Lötsch, Rieke Vingerling, Rene Spijker, Martin Peter Grobusch
BACKGROUND: Toxocariasis is a globally distributed zoonosis. The most important definitive hosts are dogs, whereas humans serve as paratenic hosts. Transmission to humans occurs by accidental ingestion of eggs, e.g. by consumption of contaminated fruit or vegetables. Although exposure to Toxocara is usually considered as relatively benign, it is implicated in a range of neurological, ophthalmologic and other organ-specific conditions, some of them with grave consequences. This review provides an overview on the epidemiology, presentation and risk factors of exposure to Toxocara in Africa...
October 13, 2017: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/28991343/endophthalmitis-following-pediatric-cataract-surgery-an-international-pediatric-ophthalmology-and-strabismus-council-global-perspective
#13
Almutez M Gharaibeh, Eedy Mezer, Luis H Ospina, Tamara Wygnanski-Jaffe
PURPOSE: To compile international data on the risk factors, diagnosis, and treatment of endophthalmitis following pediatric cataract surgery. METHODS: An e-mail containing a link to an online survey was sent to all members of the American Association for Pediatric Ophthalmology and Strabismus. The questionnaire examined the incidence, risk factors, treatment, outcomes, and prophylaxis of endophthalmitis following pediatric cataract surgery around the world. RESULTS: Two hundred thirty-seven ophthalmologists answered the questionnaire...
October 9, 2017: Journal of Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28968886/global-ethnic-and-geographic-differences-in-the-clinical-presentations-of-anti-neutrophil-cytoplasm-antibody-associated-vasculitis
#14
Fiona A Pearce, Anthea Craven, Peter A Merkel, Raashid A Luqmani, Richard A Watts
Objectives: There are few data on clinical profiles of ANCA-associated vasculitis (AAV) in different ethnic populations. The aim of this study was to examine the differences in the ANCA type and clinical features of AAV between populations using the Diagnostic and Classification Criteria in Vasculitis Study (DCVAS) dataset. Methods: The DCVAS is an international, multicentre, observational study recruiting in 133 sites. Eight ethnic categories were analysed: Northern European, Caucasian American, Southern European, Middle Eastern/Turkish, Chinese, Japanese, Indian subcontinent and other...
November 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28933972/visual-acuity-and-macular-and-peripapillary-thickness-in-high-myopia
#15
Solmaz Abdolrahimzadeh, Francesco Parisi, Andrea Maria Plateroti, Federica Evangelista, Vito Fenicia, Gianluca Scuderi, Santi Maria Recupero
PURPOSE: To investigate best corrected visual acuity (BCVA), and choroidal and retinal thickness values between high myopes without myopic maculopathy and emmetropes. MATERIALS AND METHODS: Case control study where 53 myopes with axial length (AL) above 26 mm without myopic maculopathy and 53 age-matched emmetropes with AL between 21.50 and 24.50 were included as controls. Complete ophthalmological examination and biometry were performed. Choroidal and individual retinal layer thickness maps using spectral domain optical coherence tomography were obtained in the macular and peripapillary area with enhanced depth imaging...
November 2017: Current Eye Research
https://www.readbyqxmd.com/read/28925741/endophthalmitis-following-strabismus-surgery-iposc-global-study
#16
Ofira Zloto, Eedy Mezer, Luis Ospina, Branislav Stankovic, Tamara Wygnanski-Jaffe
PURPOSE: To examine the characteristics of patients with endophthalmitis after strabismus surgery (PSSE), the characteristics of the strabismus surgery, treatment, and prognosis as reported by pediatric ophthalmologists who are members of the American Association for Pediatric Ophthalmology and Strabismus (AAOPS) around the world. METHODS: An email communication was sent to all members of AAPOS. The email included a web link to a survey that included 34 questions that examined the characteristics of patients with endophthalmitis after strabismus surgery...
September 19, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28868651/the-effects-of-preterm-birth-on-visual-development
#17
REVIEW
Myra Ps Leung, Benjamin Thompson, Joanna Black, Shuan Dai, Jane M Alsweiler
Children born very preterm are at a greater risk of abnormal visual and neurological development when compared to children born at full term. Preterm birth is associated with retinopathy of prematurity (a proliferative retinal vascular disease) and can also affect the development of brain structures associated with post-retinal processing of visual information. Visual deficits common in children born preterm, such as reduced visual acuity, strabismus, abnormal stereopsis and refractive error, are likely to be detected through childhood vision screening programs, ophthalmological follow-up or optometric care...
September 3, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28809847/genome-wide-expression-datasets-of-anti-vegf-and-dexamethasone-treatment-of-angiogenesis-in-the-rat-cornea
#18
Anthony Mukwaya, Pierfrancesco Mirabelli, Anton Lennikov, Maria Xeroudaki, Mira Schaupper, Beatrice Peebo, Neil Lagali
Therapeutics against pathologic new blood vessel growth, particularly those targeting vascular endothelial growth factor (VEGF) are of enormous clinical interest. In the eye, where anti-VEGF agents are in widespread clinical use for treating retinal and corneal blindness, only partial or transient efficacy and resistance to anti-VEGF agents are among the major drawbacks. Conversely, corticosteroids have long been used in ophthalmology for their potency in suppressing inflammation and angiogenesis, but their broad biological activity can give rise to side effects such as glaucoma and cataract...
August 15, 2017: Scientific Data
https://www.readbyqxmd.com/read/28802687/-oct-topographic-characteristics-of-the-optic-nerve-in-patients-clinically-suspected-to-have-large-optic-disc-cupping-in-togo
#19
N Maneh, K D Ayena, K Vonor, K B Nonon Saa, K M Amedome, K B Dzidzinyo, C B Ikessieba, K R Kuaovi, M Banla, K P Balo
PURPOSE: To describe topographic characteristics of optic discs clinically suspected of large cupping. MATERIALS AND METHODS: This is retrospective study conducted from the January 2 to December 31 on the OCT registry and data base of a private ophthalmologic center in Lomé (Togo). We included records of patients with large cupping - CDR (cup-to-disc ratio) ≥ 0.4 -clinically observed and having undergone OCT-optic disc analysis. RESULTS: Three hundred and thirty-five patients (619 eyes) were studied, with a mean age of 41...
September 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28783458/tele-ophthalmology-for-age-related-macular-degeneration-and-diabetic-retinopathy-screening-a-systematic-review-and-meta-analysis
#20
Atsushi Kawaguchi, Noha Sharafeldin, Aishwarya Sundaram, Sandy Campbell, Matthew Tennant, Christopher Rudnisky, Ezekiel Weis, Karim F Damji
BACKGROUND: To synthesize high-quality evidence to compare traditional in-person screening and tele-ophthalmology screening. METHODS: Only randomized controlled trials (RCTs) were included in this systematic review and meta-analysis. The intervention of interest was any type of tele-ophthalmology, including screening of diseases using remote devices. Studies involved patients receiving care from any trained provider via tele-ophthalmology, compared with those receiving equivalent face-to-face care...
August 7, 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
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