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fusarium AND hematologic diseases

Alina Tanase, Anca Colita, Gabriel Ianosi, Daniela Neagoe, Daciana Elena Branisteanu, Daniela Calina, Anca Oana Docea, Aristidis Tsatsakis, Simona Laura Ianosi
Fusarium infection is a severe fungal infection caused by fungi of the genus Fusarium. It most commonly occurs in immunocompromised patients with malignant hematological comorbidities or secondary to hematopoietic stem cell transplant. The classical route of contamination is through inhalation but infection may also occur through contiguity with a skin lesion. This report describes the case of a 24-year-old woman who developed graft-vs.-host disease (GVHD) at 220 days after receiving an allogeneic stem cell transplant from a sibling donor for Hodgkin disease...
October 2016: Experimental and Therapeutic Medicine
Anne Debourgogne, Joséphine Dorin, Marie Machouart
Over the last few decades, the number of patients susceptible to invasive filamentous fungal infections has steadily increased, especially in populations suffering from hematological diseases. The pathogens responsible for such mycoses are now quite well characterized, such as Aspergillus spp. - the most commonly isolated mold -, Mucorales, Fusarium spp., Scedosporium spp. or melanized fungi. An increase in the incidence of this category of 'emerging' fungi has been recently highlighted, evoking a shift in fungal ecology...
June 2016: Environmental Microbiology Reports
Komkrit Ruangritchankul, Ariya Chindamporn, Navaporn Worasilchai, Ubon Poumsuk, Somboon Keelawat, Andrey Bychkov
Invasive fungal disease (IFD) has high mortality rate, especially in the growing population of immunocompromised patients. In spite of introduction of novel diagnostic approaches, the intravital recognition of IFD is challenging. Autopsy studies remain a key tool for assessment of epidemiology of visceral mycoses. We aimed to determine species distribution and trends of IFD over the last 10 years in unselected autopsy series from a large university hospital. Forty-five cases of visceral mycoses, confirmed by histopathology and panfungal PCR, were found in 587 consecutive autopsies...
2015: International Journal of Clinical and Experimental Pathology
Shivashni S Deo, Balaji Virassamy, Catriona Halliday, Leighton Clancy, Sharon Chen, Wieland Meyer, Tania C Sorrell, David J Gottlieb
BACKGROUND AIMS: Invasive fungal diseases caused by filamentous fungi and yeasts are significant causes of morbidity and mortality in immunosuppressed hematology patients. We previously published a method to expand Aspergillus fumigatus-specific T cells for clinical cell therapy. In the present study, we investigated expansion of T cells specific for other fungal pathogens and creation of a broadly reactive panfungal T-cell product. METHODS: Fungal strains selected were those frequently observed in the clinical hematology setting and included Aspergillus, Candida, Fusarium, Rhizopus and Lomentospora/Scedosporium...
January 2016: Cytotherapy
Ranthilaka R Ranawaka, Ajith Nagahawatte, Thusitha Aravinda Gunasekara
BACKGROUND: Invasive fusariosis is an infection with Fusarium spp. that primarily affects patients with hematologic malignancies and hematopoietic cell transplant recipients. Wounds, digital ulcers, onychomycosis, and paronychia are the typical cutaneous portals of entry. Early management of mycotic nails in immunocompromised and diabetic hosts is crucial to prevent life-threatening disease. OBJECTIVES: We report nine cases of Fusarium onychomycosis (F. dimerum, n = 5; F...
November 2015: International Journal of Dermatology
Lena Klingspor, Baharak Saaedi, Per Ljungman, Attila Szakos
Invasive mould infection (IMI) is an important cause of morbidity and mortality in immunocompromised patients. However, Swedish epidemiology data are lacking. The aim of this study was to investigate the epidemiology and outcome of IMI. Cases of proven/probable IMI at Karolinska University Hospital, Stockholm, from 2005 to 2009, were included. A total of 100 patients with 104 episodes of IMI were enrolled. Identified isolates included 101 mould isolates. The majority of the isolates were Aspergillus spp. (74...
August 2015: Mycoses
C C Blyth, N M Gilroy, S D Guy, S T Chambers, E Y Cheong, T Gottlieb, S L McGuinness, K A Thursky
Mould species represent the pathogens most commonly associated with invasive fungal disease in patients with haematological malignancies and patients of haemopoietic stem cell transplants. Invasive mould infections in these patient populations, particularly in the setting of neutropenia, are associated with high morbidity and mortality, and significantly increase the complexity of management. While Aspergillus species remain the most prevalent cause of invasive mould infections, Scedosporium and Fusarium species and the Mucormycetes continue to place a significant burden on the immunocompromised host...
December 2014: Internal Medicine Journal
Vaibhav S Keskar, Shashir Wanjare, Tukaram E Jamale, Dinesh Mahajan, Sunil Y Jawale, Gwendolyn Fernandes, Rupali Suryawanshi, N K Hase
Fusarium is a filamentous opportunistic pathogenic fungus responsible for superficial as well as invasive infection in immunocompromized hosts. Net state of immunosuppression and cytomegalovirus (CMV) infection appear to predispose to this disease which is life-threatening when disseminated. Though infections with Fusarium have been widely described in hematological malignancies and hematopoietic stem cell transplant cases, they have been reported to be rare in solid organ transplant recipients, are often localized and carry a favorable prognosis...
August 2014: Renal Failure
A Candoni, M Caira, S Cesaro, A Busca, M Giacchino, R Fanci, M Delia, A Nosari, A Bonini, C Cattaneo, L Melillo, C Caramatti, G Milone, R Scime', M Picardi, R Fanin, L Pagano
UNLABELLED: This multicentre observational study evaluated the feasibility, efficacy and toxicity of antifungal combination therapy (combo) as treatment of proven or probable invasive fungal diseases (IFDs) in patients with haematological malignancies. Between January 2005 and January 2010, 84 cases of IFDs (39 proven and 45 probable) treated with combo were collected in 20 Hematological Italian Centres, in patients who underwent chemotherapy or allogeneic haematopoietic stem cell transplantation for haematological diseases...
June 2014: Mycoses
Thomas J Walsh, Maria N Gamaletsou
Invasive fungal infections are important causes of morbidity and attributable mortality in neutropenic patients with hematological malignancies, myelodysplasia, and aplastic anemia. Successful risk-based strategies can be implemented for prophylaxis, empirical therapy, and preemptive therapy for the prevention and early treatment of invasive fungal infections in neutropenic hosts. The use of echinocandins for invasive candidiasis and voriconazole for invasive aspergillosis has significantly improved outcome...
2013: Hematology—the Education Program of the American Society of Hematology
Shaun K Morris, Upton D Allen, Sumit Gupta, Susan E Richardson
BACKGROUND: Caspofungin is an echinocandin class antifungal medication that is commonly used empirically in immunocompromised patients at high risk for invasive fungal disease. OBJECTIVE: To describe the clinical characteristics of breakthrough fungal infections in pediatric hematopoetic stem cell transplant recipients, and oncology and hematology patients receiving caspofungin. METHODS: A five-year retrospective review, from 2004 through 2008, of all cases of proven invasive filamentous fungal infection of children admitted to The Hospital for Sick Children (Toronto, Ontario) was conducted...
2012: Canadian Journal of Infectious Diseases & Medical Microbiology
Thomas S Y Chan, Harinder Gill, Yu-Yan Hwang, Joycelyn Sim, Alan C T Tse, Florence Loong, Pek-Lan Khong, Eric Tse, Anskar Y H Leung, Chor-Sang Chim, Albert K W Lie, Yok-Lam Kwong
The frequency of breakthrough invasive fungal diseases (IFDs) during echinocandin therapy is unclear. We retrospectively analyzed 534 hematologic patients treated with echinocandin (caspofungin, N = 55; micafungin, N = 306; anidulafungin, N = 173). Four proven IFDs were found, caused by Candida parapsilosis (N = 2), C. parapsilosis and Candida glabrata (N = 1), and Fusarium species (N = 1). Four cases of possible IFDs were observed, all showing pulmonary infection. One case showed features suggestive of hepatosplenic candidiasis...
March 2014: Annals of Hematology
Bertrand Grenier, Ana-Paula F L Bracarense, Heidi E Schwartz, Joelma Lucioli, Anne-Marie Cossalter, Wulf-Dieter Moll, Gerd Schatzmayr, Isabelle P Oswald
Mycotoxin mitigation is of major interest as ingestion of mycotoxins results in poor animal health, decreased productivity, as well as substantial economic losses. A feed additive (FA) consisting of a combination of bacteria (Eubacterium BBSH797) and enzyme (fumonisin esterase FumD) was tested in pigs for its ability to neutralize the effects of mono- and co-contaminated diets with deoxynivalenol (DON) and fumonisins (FB) on hematology, biochemistry, tissue morphology, and immune response. Forty-eight animals, allocated into eight groups, received one of eight diets for 35 days: a control diet, a diet contaminated with either DON (3 mg/kg) or FB (6 mg/kg), or both toxins, and the same four diets with FA...
July 10, 2013: Journal of Agricultural and Food Chemistry
Prateek Sanghera, Victor Test, Erik Wallace
SESSION TYPE: Infectious Disease Student/Resident CasesPRESENTED ON: Tuesday, October 23, 2012 at 11:15 AM - 12:30 PMINTRODUCTION: Fusarium species are angioinvasive molds that live in soil and can cause infection through inhalation of the airborne pathogen or by entry through the skin such as in patients with preexisting onychomycosis.CASE PRESENTATION: A 53-year-old man presented with six weeks of worsening weakness, dizziness, lethargy, and dyspnea on minimal exertion with occasional low-grade fevers, night sweats and chills...
October 1, 2012: Chest
Yumiko Sugawara, Kazunori Nakase, Akiko Nakamura, Kohshi Ohishi, Yuka Sugimoto, Atushi Fujieda, Fumihiko Monma, Kei Suzuki, Masahiro Masuya, Yoshiko Matsushima, Hideo Wada, Tsutomu Nobori, Naoyuki Katayama
OBJECTIVES: Invasive fungal diseases (IFDs) are life-threatening events in patients with haematologic disorders, and the spectrum of the aetiological pathogens continues to expand. This study aimed to evaluate the clinical utility of a panfungal polymerase chain reaction (PCR) assay for the management of IFDs in such patients. METHODS: We prospectively analysed 273 consecutive blood samples from 64 risk episodes in 51 patients with haematologic disorders at high risk for IFD who were treated at our hospital between April 2007 and October 2010...
April 2013: European Journal of Haematology
Ricardo Galimberti, Ana Clara Torre, María Carolina Baztán, Florencia Rodriguez-Chiappetta
Systemic mycoses are a heterogeneous group of infections caused by different species of fungi that mainly affect individuals with primary or secondary alterations of immunity. In recent years, there has been an increase in the incidence of infections related to migration, AIDS, and other causes of immunosuppression, such as solid organ and bone marrow transplantation; oncological, hematological, and autoimmune diseases; and the use of new drugs. In this paper, we outline the microbiological and epidemiological characteristics of 3 fungi: Aspergillus spp, Fusarium spp, and Penicillium spp...
November 2012: Clinics in Dermatology
Silvana Peterini Boeira, Carlos Borges Filho, Lucian Del'Fabbro, Luiz Fernando Freire Royes, Cristiano Ricardo Jessé, Mauro Schneider Oliveira, Ana Flávia Furian
Zearalenone (ZEA) is a non-steroidal estrogenic mycotoxin produced by several species of Fusarium, commonly found in the soil in temperate and warm countries and is a frequent contaminant of cereal crops worldwide. Accordingly, it has been implicated in several mycotoxicosis in farm animals and in humans, but the underlying mechanisms remain largely unknown. Therefore, the current study was aimed to investigate the effect of an acute dose of ZEA (40 mg/kg, p.o.) on reproductive and hematological parameters, as well as on markers of oxidative stress in liver, kidney and testes in mice...
September 1, 2012: Toxicon: Official Journal of the International Society on Toxinology
Charalampos Antachopoulos, Aspasia Katragkou, Emmanuel Roilides
Invasive infections due to filamentous fungi, such as Aspergillus spp., Zygomycetes, Scedosporium and Fusarium spp., cause significant morbidity and mortality in immunocompromised patients with hematological malignancies, recipients of hematopoietic stem cell transplants and those with chronic granulomatous disease. Despite antifungal therapy, the outcome is often unfavorable in these patients; immune restoration is considered as the cornerstone of successful treatment. Important aspects of human immune response against fungi include effective innate immune response expressed as effective phagocytic functions and a balance between proinflammatory and regulatory adaptive immune responses...
January 2012: Immunotherapy
Greg P Bourgeois, Jennifer A Cafardi, Klaus Sellheyer, Aleodor A Andea
Fusarium is a saprophytic organism that is widely found distributed in soil, subterranean and aerial plants, plant debris, and other organic substrates. It can cause local tissue infections in immunocompetent patients, such as onychomycosis, bone and joint infections, or sinusitis. The incidence of disseminated disease has notably increased since the initial cases of disseminated Fusarium were described, particularly affecting immunocompromised patients with hematologic malignancies. We report a 39-year-old man hospitalized with newly diagnosed acute myelocytic leukemia who developed disseminated Fusarium infection originating from toenail paronychia in the setting of neutropenia...
April 2010: Cutis; Cutaneous Medicine for the Practitioner
Christoph Müller, Ulrike Schumacher, Michael Gregor, Georg Lamprecht
BACKGROUND: Catheter-related sepsis is the most frequent complication in patients receiving home parenteral nutrition (HPN) for short bowel syndrome (SBS). A low-grade systemic inflammatory state and an altered mucosal immune response, as well as diminished intestinal barrier function have been characterized in these patients. The possibility of systemic immunocompromise has only recently been suggested. CASE DESCRIPTION: A 45-year-old female with traumatic SBS was admitted for possible catheter-related sepsis...
November 2009: JPEN. Journal of Parenteral and Enteral Nutrition
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