Ilanah J Pruis, Pieter Jan van Doormaal, Rutger K Balvers, Martin J van den Bent, Anita A Harteveld, Linda C de Jong, Mark W Konijnenberg, Marcel Segbers, Roelf Valkema, Frederik A Verburg, Marion Smits, Sophie E M Veldhuijzen van Zanten
BACKGROUND: The aim of this study was to provide quantitative evidence for the potential of PSMA-targeting radioligand therapy (RLT) as treatment approach for malignant brain tumours, and to explore whether tumour uptake could be enhanced by super-selective intra-arterial (ssIA)-administration. METHODS: Ten patients (n = 5 high-grade glioma, n = 5 brain metastasis) received 1.5 MBq/kg [68 Ga]Ga-PSMA-11 intravenously and, within 7 days, intra-arterially (i...
March 21, 2024: EBioMedicine