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https://www.readbyqxmd.com/read/28818992/long-half-life-89-zr-labeled-radiotracers-can-guide-in-suite-percutaneous-molecular-imaging-pet-ct-guided-biopsies-without-reinjection-of-radiotracer
#1
Francois H Cornelis, Jeremy Durack, Neeta Pandit-Taskar, Gary A Ulaner, Jason S Lewis, Michael J Morris, Stephen B Solomon
Rationale: To evaluate the feasibility of in suite Zr89 labeled radiotracer positron emission tomography-computed tomography (PET/CT)-guided biopsies performed without reinjection. Methods: From 2013-2016, 12 patients (7 males, 5 females; mean age 61 years, range 40-75) with suspected metastatic prostate or breast carcinoma on either imaging or biochemical progression underwent 14 percutaneous biopsies after diagnostic PET/CT using (89)Zr labeled radiotracers (mean dose: 180MBq; range: 126-189MBq) targeting prostate specific membrane antigen (PSMA) (n = 7) or human epidermal growth factor receptor 2 (HER2) (n = 5)...
August 17, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28817656/investigation-of-the-halo-artifact-in-68ga-psma-11-pet-mri
#2
Thorsten Heußer, Philipp Mann, Christopher M Rank, Martin Schäfer, Antonia Dimitrakopoulou-Strauss, Heinz-Peter Schlemmer, Boris A Hadaschik, Klaus Kopka, Peter Bachert, Marc Kachelrieß, Martin T Freitag
OBJECTIVES: Combined positron emission tomography (PET) and magnetic resonance imaging (MRI) targeting the prostate-specific membrane antigen (PSMA) with a 68Ga-labelled PSMA-analog (68Ga-PSMA-11) is discussed as a promising diagnostic method for patients with suspicion or history of prostate cancer. One potential drawback of this method are severe photopenic (halo-) artifacts surrounding the bladder and the kidneys in the scatter-corrected PET images, which have been reported to occur frequently in clinical practice...
2017: PloS One
https://www.readbyqxmd.com/read/28815472/comparison-of-pet-ct-and-whole-mount-histopathology-sections-of-the-human-prostate-a-new-strategy-for-voxel-wise-evaluation
#3
F Schiller, T Fechter, C Zamboglou, A Chirindel, N Salman, C A Jilg, V Drendel, M Werner, P T Meyer, A-L Grosu, M Mix
BACKGROUND: Implementation of PET/CT in diagnosis of primary prostate cancer (PCa) requires a profound knowledge about the tracer, preferably from a quantitative evaluation. Direct visual comparison of PET/CT slices to whole prostate sections is hampered by considerable uncertainties from imperfect coregistration and fundamentally different image modalities. In the current study, we present a novel method for advanced voxel-wise comparison of histopathology from excised prostates to pre-surgical PET...
August 17, 2017: EJNMMI Physics
https://www.readbyqxmd.com/read/28806262/an-unusual-case-of-penile-prostate-cancer-uncovered-by-multiparametric-mri-and-psma-targeted-18f-dcfpyl-pet-ct
#4
Steven P Rowe, Michael A Gorin, Linda C Chu, Kenneth J Pienta, Martin G Pomper, Ashley E Ross, Katarzyna J Macura
Multiparametric MRI (mpMRI) is currently the test of choice for imaging sites of prostate cancer located within the pelvis. However, molecular imaging with PET radiotracers that bind to prostate-specific membrane antigen is increasingly being used for this purpose and may compliment mpMRI findings. We present a case of a 59-year-old man with elevated postprostatectomy serum prostate-specific antigen level who was found on both mpMRI and prostate-specific membrane antigen-targeted PET to harbor residual prostate cancer in the corpus spongiosum along the proximal urethra...
August 12, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28806260/68ga-psma-ligand-pet-ct-uptake-in-anthracosilicosis
#5
Madeleine McGuiness, Brett Sounness
This interesting image illustrates a case of biopsy-proven pulmonary anthracosilicosis, a mixed dust pneumoconiosis, associated with Ga-PSMA-ligand uptake. Prostate-specific membrane antigen (PSMA) is an emerging imaging biomarker, with clinical application in evaluation of prostate cancer using Ga-PSMA-ligand PET/CT. Contrary to its name, PSMA is expressed in a number of other normal tissues and pathological states. Prostate-specific membrane antigen expression has been linked to tumor angiogenesis in various other epithelial neoplasms, as well as neovasculature associated with tissue regeneration and repair...
August 12, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28806238/68ga-psma-uptake-in-combined-hepatocellular-cholangiocarcinoma-with-skeletal-metastases
#6
Ramin Alipour, Sandeep Gupta, Scott Trethewey
Ga-PSMA PET is a rapidly evolving imaging modality for whole-body staging of prostate cancer. We report a case of a 70-year-old man with mildly elevated prostate-specific antigen (8.1 μg/L) and clinical suspicion of prostate cancer (osteoblastic metastases on radionuclide bone scan) who was referred for Ga-PSMA PET/CT for primary staging. Multiple Ga-PSMA-avid skeletal foci, mostly associated with lytic changes on low-dose CT, as well as hepatic foci of avid Ga-PSMA uptake, were identified. No abnormal focus of avid Ga-PSMA uptake was identified in the prostate...
August 12, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28801787/reduction-of-68-ga-psma-renal-uptake-with-mannitol-infusion-preliminary-results
#7
Federica Matteucci, Emilio Mezzenga, Paola Caroli, Valentina Di Iorio, Anna Sarnelli, Monica Celli, Lorenzo Fantini, Andrea Moretti, Riccardo Galassi, Ugo De Giorgi, Giovanni Paganelli
PURPOSE: Urea-based prostate-specific membrane antigen (PSMA) ligands labelled with (68)Ga or (177)Lu are new tracers with great potential for theranostic approaches in prostate cancer. However, clinical studies have shown that the kidneys are one of the off-target organs along with the salivary and lacrimal glands. In the kidneys, PSMA is physiologically expressed in the apical epithelium of the proximal tubules, and mannitol acts as an osmotic diuretic in these tubules. We investigated the potential of mannitol to reduce renal uptake of (68)Ga-PSMA...
August 11, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28797928/comparison-of-planar-pet-and-well-counter-measurements-of-total-tumor-radioactivity-in-a-mouse-xenograft-model
#8
Michael V Green, Jurgen Seidel, Mark R Williams, Karen J Wong, Anita Ton, Falguni Basuli, Peter L Choyke, Elaine M Jagoda
INTRODUCTION: Quantitative small animal radionuclide imaging studies are often carried out with the intention of estimating the total radioactivity content of various tissues such as the radioactivity content of mouse xenograft tumors exposed to putative diagnostic or therapeutic agents. We show that for at least one specific application, positron projection imaging (PPI) and PET yield comparable estimates of absolute total tumor activity and that both of these estimates are highly correlated with direct well-counting of these same tumors...
June 30, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28795303/the-feasibility-of-prostate-specific-membrane-antigen-positron-emission-tomography-psma-pet-ct-guided-radiotherapy-in-oligometastatic-prostate-cancer-patients
#9
O C Guler, B Engels, C Onal, H Everaert, R Van den Begin, T Gevaert, M de Ridder
BACKGROUND: To investigate the efficacy and toxicity of 68Ga-PSMA-HBED-CC ((68)Ga-PSMA) PET-CT-guided RT in the treatment of oligometastatic prostate cancer retrospectively. METHODS: A total of 23 prostate cancer patients with biochemical relapse, of which 13 were castration sensitive (CS) and 10 castration resistant (CR), were treated with intensity-modulated and image-guided RT (IMRT-IGRT) on ≤3 metastases detected by (68)Ga PSMA PET-CT. Androgen deprivation therapy was continued in CR patients...
August 9, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28777073/multimodality-image-fusion-with-psma-pet-ct-and-high-intensity-focused-ultrasound-focal-therapy-for-primary-diagnosis-and-management-of-prostate-cancer-a-planned-research-initiative
#10
Marcia C Javitt, Alexander Kravtsov, Zohar Keidar, Sobhi Abadi, Gilad Amiel
Recent developments in diagnostic imaging herald a new approach to diagnosis and management of prostate cancer. Multimodality fusion that combines anatomic with functional imaging data has surpassed either of the two alone. This opens up the possibility to "find and fix" malignancy with greater accuracy than ever before. This is particularly important for prostate cancer because it is the most common male cancer in most developed countries. This article describes technical advances under investigation at our institution and others using multimodality image fusion of magnetic resonance imaging (MRI), transrectal ultrasound (TRUS), and PSMA PET/CT (defined as the combination of prostate-specific membrane antigen [PSMA], positron emission tomography [PET], and computed tomography [CT]) for personalized medicine in the diagnosis and focal therapy of prostate cancer with high-intensity focused ultrasound (HiFUS)...
August 3, 2017: Rambam Maimonides Medical Journal
https://www.readbyqxmd.com/read/28775203/immunohistochemical-validation-of-psma-expression-measured-by-68-ga-psma-pet-ct-in-primary-prostate-cancer
#11
Nadine Woythal, Ruza Arsenic, Carsten Kempkensteffen, Kurt Miller, Jan-Carlo Janssen, Kai Huang, Marcus R Makowski, Winfried Brenner, Vikas Prasad
Aim: Gallium 68 ((68)Ga) prostate specific membrane antigen (PSMA) positron emission tomography/computed tomography ((68)Ga-PSMA PET/CT) has a proven role in staging and restaging of prostate cancer (PCA) patients. The aims of this study were to evaluate the association of intraprostatic (68)Ga-PSMA PET/CT (PET) findings and prostate specific membrane antigen (PSMA) expression in immunohistochemical staining (IHC) and generate a cut-off value for the differentiation between benign prostate tissue from PCA. Methods: Data of 31 patients (mean 67...
August 3, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28765999/a-rare-case-of-thymoma-first-detected-on-gallium-68-psma-pet-ct
#12
Hian Liang Huang, Angela Renayanti Dharmawan, Colin Jingxian Tan, Sue Ping Thang
No abstract text is available yet for this article.
August 1, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28765998/pearls-and-pitfalls-in-clinical-interpretation-of-prostate-specific-membrane-antigen-psma-targeted-pet-imaging
#13
REVIEW
Sara Sheikhbahaei, Ali Afshar-Oromieh, Matthias Eiber, Lilja B Solnes, Mehrbod S Javadi, Ashley E Ross, Kenneth J Pienta, Mohamad E Allaf, Uwe Haberkorn, Martin G Pomper, Michael A Gorin, Steven P Rowe
BACKGROUND: The rapidly expanding clinical adaptation of prostate-specific membrane antigen (PSMA)-targeted PET imaging in the evaluation of patients with prostate cancer has placed an increasing onus on understanding both the potential pearls of interpretation as well as limitations of this new technique. As with any new molecular imaging modality, accurate characterization of abnormalities on PSMA-targeted PET imaging can be accomplished only if one is aware of the normal distribution pattern, physiological variants of radiotracer uptake, and potential sources of false-positive and false-negative imaging findings...
August 1, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28762288/the-phytological-future-of-prostate-cancer-staging-prostate-specific-membrane-antigen-positron-emission-tomography-and-the-dandelion-theory
#14
Niranjan J Sathianathen, Nicolas Geurts, Rajesh Nair, Nathan Lawrentschuk, Declan G Murphy, Alastair D Lamb
PSMA-PET is changing how we stage prostate cancer, both in the primary setting and with relapse after treatment. It allows us to identify lesions in the bones and lymph nodes that were not previously visible on conventional imaging with bone scan and CT/MRI. In this Special Report we review the 'state of the art' for PSMA imaging and discuss the implications for treatment decisions in prostate cancer. We liken early high risk or metastatic prostate to a common phytological problem: the dandelion. In this analogous situation, we consider the additional evidence needed for us to start plucking out the original dandelion and for us to focus attention on killing the seeded weeds that are identifiable elsewhere in the lawn...
August 1, 2017: Future Oncology
https://www.readbyqxmd.com/read/28759526/68ga-psma-uptake-in-an-incidentally-detected-gastrointestinal-stromal-tumor-in-a-case-of-suspected-carcinoma-prostate
#15
Arun Sasikumar, Ajith Joy, Mra Pillai, Bindu S, Sudin Sr
A 74-year-old man with suspected prostate cancer and a previously negative transrectal ultrasound-guided prostate biopsy underwent Ga-PSMA PET/CT. Scan showed no abnormal tracer concentration in enlarged prostate gland to suggest prostate cancer. Note was made of an incidentally detected well defined soft tissue lesion in the greater curvature of the stomach with moderate tracer concentration in its intraluminal portion. Biopsy of the lesion revealed gastrointestinal stromal tumor.
July 29, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28759521/68ga-psma-uptake-in-neurofibromas-demonstrated-on-pet-ct-in-a-patient-with-neurofibromatosis-type-1
#16
Brook Gulhane, Stuart Ramsay, William Fong
We present a case of Ga-PSMA PET/CT imaging of PSMA expression in neurofibromas in a patient with neurofibromatosis type 1 (or von Recklinghausen disease). PSMA uptake has previously been demonstrated in schwannomas both with PET and histological staining. The presented images confirm that PSMA expression in cutaneous neurofibromas can be well imaged with PET, with uptake mostly at relatively low levels. Interestingly, some lesions demonstrated significantly higher PSMA expression, although the clinical significance of these differences remains to be determined...
July 29, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28758969/assessment-of-bone-metastases-in-patients-with-prostate-cancer-a-comparison-between-99m-tc-bone-scintigraphy-and-68-ga-ga-psma-pet-ct
#17
Lena Thomas, Caroline Balmus, Hojjat Ahmadzadehfar, Markus Essler, Holger Strunk, Ralph A Bundschuh
PURPOSE: Bone scintigraphy is the standard of reference in bone metastases in prostate cancer patients. However, new radiotracers employed in prostate-specific membrane antigen (PSMA)-ligands has led to the growing importance of PET/CT as diagnostic tool. The aim of our study was to investigate the difference between bone scan and PSMA-PET/CT for the detection of bone metastases in prostate cancer. METHODS: Thirty patients with bone metastases originating from prostate cancer were examined by (99m)Tc-MDP bone scan and (68)Ga-PSMA-PET/CT within an average of 21 days...
July 31, 2017: Pharmaceuticals
https://www.readbyqxmd.com/read/28753806/-68-ga-labeled-prostate-specific-membrane-antigen-ligand-positron-emission-tomography-computed-tomography-for-prostate-cancer-a-systematic-review-and-meta-analysis
#18
REVIEW
Finn E von Eyben, Maria Picchio, Rie von Eyben, Handoo Rhee, Glenn Bauman
CONTEXT: (68)Gallium prostate-specific membrane antigen (PSMA) ligand (68)Ga-HBED-CC-PSMA ((68)Ga-PSMA) is a promising radiotracer for positron emission tomography (PET)/computed tomography (CT) of prostate cancer. OBJECTIVE: To conduct a meta-analysis to evaluate detection rate, diagnostic test accuracy, and adverse effects of (68)Ga-PSMA PET/CT or PET/magnetic resonance imaging (MRI) for staging of prostate cancer and for restaging of rising prostate-specific antigen (PSA) after initial treatment...
November 15, 2016: European Urology Focus
https://www.readbyqxmd.com/read/28753797/-18-f-dcfpyl-positron-emission-tomography-magnetic-resonance-imaging-for-localization-of-dominant-intraprostatic-foci-first-experience
#19
Glenn Bauman, Peter Martin, Jonathan D Thiessen, Reggie Taylor, Madeleine Moussa, Mena Gaed, Irina Rachinsky, Zahra Kassam, Joseph Chin, Stephen Pautler, Ting Yim Lee, John F Valliant, Aaron Ward
An ongoing prospective study is acquiring preoperative imaging data for men with prostate cancer (PCa) using the molecular imaging agent [(18)F]-DCFPyL targeted against prostate-specific membrane antigen (PSMA). To date, six men (of a planned accrual of 24) with clinically localized, biopsy-proven PCa have undergone preoperative [(18)F]-DCFPyL positron emission tomography (PET) imaging and multiparametric magnetic resonance imaging acquired using a hybrid PET/MRI system. Lesions identified by [(18)F]-DCFPyL uptake on PET/MRI were characterized in terms of maximum standardized uptake value (SUVmax) and volume using a boundary threshold of 40% SUVmax...
October 26, 2016: European Urology Focus
https://www.readbyqxmd.com/read/28750750/value-of-post-therapy-177-lu-psma-images-for-accurate-interpretation-of-therapy-response-with-68-ga-psma-pet-ct
#20
M Tuncel, T Telli
A 54-year-old man with progressive prostate cancer underwent a (68)Ga-PSMA-PET/CT, which showed lymph node and bone metastases. After 2-cycles of (177)Lu-PSMA therapy, the repeated (68)Ga-PSMA PET/CT showed decreased radiotracer uptake in lymph node and bones metastases, but there were new lesions which may be compatible with progression or tumour sink-effect. A review of (177)Lu-PSMA-therapy images revealed that new lesions in the second PET/CT were the metastatic lesions that progressed after the first PET/CT, and subsequently showed a good response...
July 24, 2017: Revista Española de Medicina Nuclear e Imagen Molecular
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