keyword
https://read.qxmd.com/read/38546825/diagnostic-value-of-dual-time-point-68-ga-psma-pet-ct-image-for-benign-and-malignant-lesions-in-patients-with-prostate-cancer
#1
JOURNAL ARTICLE
Liu Xiao, Minggang Su, Yuhao Li
OBJECTIVE: This study aimed to ascertain the diagnostic efficacy of routine 68 Ga-PSMA imaging conducted 1 h post-injection, in conjunction with delayed imaging performed 3 h post-injection, for differentiating between benign and malignant lesions in prostate cancer (PCa) patients. METHODS: A retrospective assessment was undertaken on 44 prostate cancer patients who had undergone both routine and delayed 68 Ga-PSMA PET/CT scans. Variations in SUVmax and SUVmean values in normal organs, primary prostate cancer sites, metastatic sites, and benign lesions were analyzed...
March 28, 2024: Abdominal Radiology
https://read.qxmd.com/read/38545506/agreement-between-psma-rads-and-e-psma-systems-in-classifying-18-f-psma-1007-pet-ct-lesions-among-prostate-cancer-patients-exploring-the-correlation-between-lesion-size-and-uptake
#2
JOURNAL ARTICLE
Miguel Mendoza-Ávila, Hiram Esparza-Pérez, Juan Andrés Castillo-López, Edel Rafael Rodea-Montero
PURPOSE: To determine the agreement between the PSMA-RADS and E-PSMA standardized reporting systems in the classification of [18 F]PSMA-1007-uptaking lesions identified on PET/CT scan in patients with prostate cancer (PCa) and post-prostatectomy with suspected recurrent disease (local recurrence, regional nodal involvement and distant metastases), based on biochemical recurrence, while also exploring the correlation between lesion size and tracer uptake. MATERIALS AND METHODS: A retrospective cross-sectional study of 32 post-prostatectomy PCa patients who had suspected recurrent disease based on biochemical recurrence post-prostatectomy (prostate-specific antigen values that are 0...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38541029/the-application-of-radiomics-and-ai-to-molecular-imaging-for-prostate-cancer
#3
REVIEW
William Tapper, Gustavo Carneiro, Christos Mikropoulos, Spencer A Thomas, Philip M Evans, Stergios Boussios
Molecular imaging is a key tool in the diagnosis and treatment of prostate cancer (PCa). Magnetic Resonance (MR) plays a major role in this respect with nuclear medicine imaging, particularly, Prostate-Specific Membrane Antigen-based, (PSMA-based) positron emission tomography with computed tomography (PET/CT) also playing a major role of rapidly increasing importance. Another key technology finding growing application across medicine and specifically in molecular imaging is the use of machine learning (ML) and artificial intelligence (AI)...
March 7, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38539457/the-role-of-psma-pet-imaging-in-the-classification-of-the-risk-of-prostate-cancer-patients-a-systematic-review-on-the-insights-to-guide-an-active-surveillance-approach
#4
REVIEW
Francesco Dondi, Alessandro Antonelli, Nazareno Suardi, Giorgio Treglia, Francesco Bertagna
BACKGROUND: active surveillance (AS) is a suitable strategy for patients with prostate cancer (PCa). Prostate-specific membrane antigen (PSMA) positron emission tomography (PET) imaging is an established tool used to assess PCa. The aim of this review was to evaluate the role of PSMA imaging to guide correct risk-based classification and the AS approach in PCa patients. METHODS: The Scopus, Embase, Web of Science, Cochrane Library, and PubMed/MEDLINE databases were screened to find relevant published articles...
March 11, 2024: Cancers
https://read.qxmd.com/read/38537220/incidental-detection-of-synchronous-benign-hepatic-and-splenic-hemangiomas-on-18f-psma-pet-ct
#5
JOURNAL ARTICLE
Mohammed Hussain Alsaleh, Ali Saleh Alkhars, Mohammed Albensaad, Abedallatif Alsharif
A 51-year-old man with biochemical failure after brachytherapy for prostatic adenocarcinoma (PSA 5 μg/L rising to 6.45 μg/L) underwent a PSMA PET/CT scan. The scan revealed focal 18F-PSMA activity at the right apex suggestive of local residual or recurrent disease. In addition, 18F-PSMA images demonstrated 2 focal 18F-PSMA-avid liver and spleen lesions; both lesions were further evaluated by abdominal MRI, and the final radiological diagnosis was synchronous hepatic and splenic hemangiomas.
March 25, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38537218/intense-psma-uptake-in-solitary-fibrous-tumor-of-the-seminal-vesicle
#6
JOURNAL ARTICLE
Qian Zhao, Aisheng Dong, Huamao Ye, Changjing Zuo
Solitary fibrous tumor arising from the seminal vesicle is very rare. We describe 18F-PSMA-1007 PET/CT findings in a case of prostate adenocarcinoma with a solitary fibrous tumor of the left seminal vesicle. The solitary fibrous tumor showed intense 18F-PSMA-1007 uptake mimicking metastatic prostate adenocarcinoma. This case indicates that solitary fibrous tumor may cause false-positive result when using PSMA PET in staging of prostate cancer.
March 25, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38537212/complete-resolution-of-locally-advanced-prostate-cancer-after-molecular-endoradiotherapy-with-177lu-psma
#7
JOURNAL ARTICLE
Mohsen Beheshti, Reza Vali, Soroush Zarehparvar Moghadam, HamidReza Amini, Masoumeh Hakiminejad, GhasemAli Divband
A 76-year-old man with castration-resistant prostate cancer underwent 68Ga-prostate-specific membrane antigen (PSMA) PET/CT for restaging. A large PSMA-avid tumor with invasion to adjacent organs was noted causing gross hematuria and symptomatic anemia. Two cycles of 177Lu-PSMA were administered, and the patient showed significant reduction of hematuria as well as declining in PSA levels. 177Lu-PSMA therapy can be a good treatment option in patients with locally invasive tumors.
March 25, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38537209/enchondroma-on-bone-scan-and-psma-pet-ct-in-a-patient-with-prostate-cancer
#8
JOURNAL ARTICLE
Charisma DeSai, Lesley Flynt, Sanjit Om Tewari, Yang Lu
A 54-year-old man with Gleason 9 prostate cancer with reported nodal and skeletal metastases was referred to us. Outside hospital reports described abnormal left proximal humerus activity on bone scan concerning for metastasis; however, concurrent PSMA PET/CT did not show activity in this lesion. Further review of the PET/CT images revealed characteristic features of enchondroma in the left humeral lesion.
March 25, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38537177/an-unexpected-seminal-vesicle-pitfall-in-psma-pet
#9
JOURNAL ARTICLE
Angela Bronte, Juan J Rosales, Marcos Torres Roca, Bernardino Miñana, Macarena Rodríguez-Fraile
A 76-year-old man undergoing hormone therapy for prostate cancer was referred for 68Ga-PSMA-11-PET (PSMA PET) due to persistently detectable PSA level. No PSMA-positive tumor lesions were detected, so a delayed phase imaging was performed, which revealed focal PSMA uptake in the right seminal vesicle together with contrast accumulation on excretory phase contrast-enhanced CT. These findings were finally determined to be secondary to urinary reflux as a consequence of a prostatic enucleation he had undergone 5 months earlier following an episode of acute urinary retention...
March 25, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38534999/a-comparison-of-68-ga-psma-pet-ct-based-split-renal-function-with-99m-tc-mag3-renography-in-patients-with-metastatic-castration-resistant-prostate-carcinoma-treated-with-177-lu-psma
#10
JOURNAL ARTICLE
Lerato Gabela, Thokozani Mkhize, Bawinile Hadebe, Lerwine Harry, Thembelihle Nxasana, Nontobeko Ndlovu, Venesen Pillay, Sphelele Masikane, Maryam Patel, Nozipho Elizabeth Nyakale, Mariza Vorster
BACKGROUND: Physiological PSMA expression in the cells of the proximal renal tubules and consecutive radiopharmaceutical binding and retention could potentially lead to radioligand-therapy-induced nephrotoxicity. Thus, patients with metastatic castration-resistant prostate cancer undergo 99m Tc-Mercaptoacetyltriglycine (MAG3) renal scintigraphy to assess kidney function and to exclude renal obstruction as part of their workup for PSMA-targeted radioligand therapy (RLT). 99m Tc-MAG-3 renal scintigraphy often requires an additional visit to the nuclear medicine department and patients spend 30-90 min in the department, which is inconvenient and takes up camera time...
March 8, 2024: Diagnostics
https://read.qxmd.com/read/38534099/psma-pet-ct-in-the-low-to-intermediate-risk-prostate-cancer-when-and-why
#11
JOURNAL ARTICLE
Luca Sofia, Matteo Bauckneht
No abstract text is available yet for this article.
March 26, 2024: Asian Journal of Andrology
https://read.qxmd.com/read/38526647/machine-learning-based-analysis-of-68-ga-psma-11-pet-ct-images-for-estimation-of-prostate-tumor-grade
#12
JOURNAL ARTICLE
Maziar Khateri, Farshid Babapour Mofrad, Parham Geramifar, Elnaz Jenabi
Early diagnosis of prostate cancer, the most common malignancy in men, can improve patient outcomes. Since the tissue sampling procedures are invasive and sometimes inconclusive, an alternative image-based method can prevent possible complications and facilitate treatment management. We aim to propose a machine-learning model for tumor grade estimation based on 68  Ga-PSMA-11 PET/CT images in prostate cancer patients. This study included 90 eligible participants out of 244 biopsy-proven prostate cancer patients who underwent staging 68 Ga-PSMA-11 PET/CT imaging...
March 25, 2024: Physical and engineering sciences in medicine
https://read.qxmd.com/read/38526143/distinguishing-spheno-orbital-metastatic-prostate-cancer-mimicking-a-meningioma-using-novel-18-f-psma-pet-ct-imaging
#13
JOURNAL ARTICLE
Yilin Feng, Carolina A Chiou, Anna M Stagner, Yuh-Shin Chang, Suzanne K Freitag
A 78-year-old man presented with acute-onset left temporal pain, eyelid swelling, and double vision. Computed tomography (CT) demonstrated a left sphenoid wing mass with extra-osseous intra-orbital and intracranial extension, thought to be a typical sphenoid wing meningioma by the primary team. The patient was admitted for an urgent craniotomy, which was planned for the following day. However, upon consultation with ophthalmic plastic surgery, concern was raised for an alternative diagnosis given the atypical timeline, inflammatory changes, and uncharacteristic imaging findings of mixed lytic and sclerotic bony changes without hyperostosis on CT and extensive peri-lesional dural thickening and enhancement on magnetic resonance imaging...
March 25, 2024: Orbit
https://read.qxmd.com/read/38520513/whole-body-tumour-burden-on-18f-dcfpyl-pet-ct-in-biochemical-recurrence-of-prostate-cancer-association-with-tumour-biology-and-psa-kinetics
#14
JOURNAL ARTICLE
Laura García-Zoghby, Mariano Amo-Salas, Ángel María Soriano Castrejón, Ana María García Vicente
PURPOSE: The objective was to assess the association between molecular imaging (mi) variables on [18F]DCFPyL-PET/CT with clinical and disease characteristics and prostate specific antigen (PSA) related variables in patients with biochemical recurrence of prostate cancer (BRPC). MATERIAL AND METHODS: We analysed patients with BRPC after radical treatment. We obtained clinical and PSA variables: International Society of Urology Pathology (ISUP) grade group, European Association of Urology (EAU) risk classification, PSA (PSA≤1ng/ml, 1<PSA≤2, PSA>2), PSA doubling time (PSAdt) and PSA velocity (PSAvel)...
March 23, 2024: European Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38519802/is-extended-pelvic-lymph-node-dissection-really-required-for-staging-of-prostate-cancer-in-the-psma-pet-era
#15
REVIEW
Matthew J Roberts, John W Yaxley, Johan Stranne, Inge M van Oort, Derya Tilki
No abstract text is available yet for this article.
March 22, 2024: Prostate Cancer and Prostatic Diseases
https://read.qxmd.com/read/38518652/potential-of-psma-targeting-radioligand-therapy-for-malignant-primary-and-secondary-brain-tumours-using-super-selective-intra-arterial-administration-a-single-centre-open-label-non-randomised-prospective-imaging-study
#16
JOURNAL ARTICLE
Ilanah J Pruis, Pieter Jan van Doormaal, Rutger K Balvers, Martin J van den Bent, Anita A Harteveld, Linda C de Jong, Mark W Konijnenberg, Marcel Segbers, Roelf Valkema, Frederik A Verburg, Marion Smits, Sophie E M Veldhuijzen van Zanten
BACKGROUND: The aim of this study was to provide quantitative evidence for the potential of PSMA-targeting radioligand therapy (RLT) as treatment approach for malignant brain tumours, and to explore whether tumour uptake could be enhanced by super-selective intra-arterial (ssIA)-administration. METHODS: Ten patients (n = 5 high-grade glioma, n = 5 brain metastasis) received 1.5 MBq/kg [68 Ga]Ga-PSMA-11 intravenously and, within 7 days, intra-arterially (i...
March 21, 2024: EBioMedicine
https://read.qxmd.com/read/38514483/the-superior-detection-rate-of-total-body-68-ga-ga-psma-11-pet-ct-compared-to-short-axial-field-of-view-68-ga-ga-psma-11-pet-ct-for-early-recurrent-prostate-cancer-patients-with-psa%C3%A2-%C3%A2-0-2%C3%A2-ng-ml-after-radical-prostatectomy
#17
JOURNAL ARTICLE
Yining Wang, Liang Dong, Haitao Zhao, Lianghua Li, Gang Huang, Wei Xue, Jianjun Liu, Ruohua Chen
BACKGROUND AND PURPOSE: [68 Ga]Ga-PSMA PET imaging has been extensively utilized for the detection of biochemical recurrence (BCR) in prostate cancer. However, the detection rate declines to merely 10-40% when PSA levels are < 0.2 ng/mL employing short axial field-of-view (SAFOV) PET. Prior studies exhibited superior detection rates with total-body [68 Ga]Ga-PSMA-11 PET compared to SAFOV [68 Ga]Ga-PSMA-11 PET in BCR patients with PSA > 0.2 ng/mL...
March 22, 2024: European Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38513292/neural-blind-deconvolution-for-deblurring-and-supersampling-psma-pet
#18
JOURNAL ARTICLE
Caleb Sample, Arman Rahmim, Carlos Felipe Uribe, François Bénard, Jonn Wu, Roberto Fedrigo, Haley Clark
Objective : To simultaneously deblur and supersample prostate specific membrane antigen (PSMA) positron emission tomography (PET) images using neural blind deconvolution. Approach : Blind deconvolution is a method of estimating the hypothetical "deblurred" image along with the blur kernel (related to the point spread function) simultaneously. Traditional maximum a posteriori blind deconvolution methods require stringent assumptions and suffer from convergence to a trivial solution. A method of modelling the deblurred image and kernel with independent neural networks, called "neural blind deconvolution" had demonstrated success for deblurring 2D natural images in 2020...
March 21, 2024: Physics in Medicine and Biology
https://read.qxmd.com/read/38510820/convoluted-neural-network-for-detection-of-clinically-significant-prostate-cancer-on-68-%C3%A2-ga-psma-pet-ct-delayed-imaging-by-analyzing-radiomic-features
#19
JOURNAL ARTICLE
Rajender Kumar, Arivan Ramachandran, Bhagwant Rai Mittal, Harmandeep Singh
PURPOSE: To assess the utility of convoluted neural network (CNN) in differentiating clinically significant and insignificant prostate cancer in patients with 68  Ga PSMA PET/CT-targeted prostate biopsy-proven prostate cancer. METHODS: In this retrospective study, 142 patients with clinical suspicion of prostate cancer were evaluated who underwent 68  Ga-PSMA PET/CT imaging followed by 68  Ga-PSMA PET/CT-targeted prostate biopsy from the PSMA-avid prostate lesion...
April 2024: Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38504659/key-learnings-from-concordant-systematic-biopsies-in-prostate-specific-membrane-antigen-positron-emission-tomography-computed-tomography-guided-prostate-biopsies-enhancing-targeting-accuracy
#20
JOURNAL ARTICLE
Thomas Büttner, Florian Gärtner, Markus Essler, Richard Weiten, Glen Kristiansen, Jörg Ellinger, Manuel Ritter, Philipp Krausewitz
BACKGROUND: Prostate cancer (PCa) diagnosis and staging have evolved with the advent of 68Ga-Prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA-PET/CT). This study investigates the role of complementary systematic biopsies (SB) during PSMA-PET/CT-guided targeted prostate biopsies (PET-TB) for PCa detection, grading, and distribution. We address the uncertainty surrounding the necessity of SB in conjunction with PET-TB. METHODS: We analyzed PCa grading and distribution in 30 men who underwent PET-TB and SB because of contraindication to magnetic resonance imaging or high clinical suspicion of PCa...
March 20, 2024: Prostate
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