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https://www.readbyqxmd.com/read/28074210/diagnostic-value-of-additional-68-ga-psma-pet-before-223-ra-dichloride-therapy-in-patients-with-metastatic-prostate-carcinoma
#1
Axel Bräuer, Kambiz Rahbar, Julia Konnert, Martin Bögemann, Lars Stegger
PURPOSE: Medical imaging plays an important role in selecting patients with metastatic castration-resistant prostate cancer for (223)Ra-dichloride therapy of bone metastases. The purpose of this study was to investigate whether (68)Ga-PSMA-PET has incremental value over conventional imaging for selecting patients suitable for (223)Ra-dichloride therapy. METHODS: In 27 consecutive patients referred for (223)Ra-dichloride therapy additional (68)Ga-PSMA-PET/CT was performed and tracer distribution was evaluated systematically with respect to the detection of visceral metastases and bone metastases with inadequate uptake on bone scintigraphy...
January 11, 2017: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/28072616/gastrointestinal-stromal-tumor-showing-intense-tracer-uptake-on-psma-pet-ct
#2
Benjamin Noto, Matthias Weckesser, Boris Buerke, Michaela Pixberg, Nemanja Avramovic
A 70-year-old man with suspected prostate cancer was referred for Ga-PSMA-HBED-CC PET/CT (short PSMA PET/CT) for staging of tumor extent. Apart from vivid tracer uptake in the prostate gland and osseous metastasis, PSMA PET/CT revealed a large soft tissue mass with calcifications in the left upper abdomen showing intense tracer uptake. Histologic examination revealed the mass to be a gastrointestinal stromal tumor.
January 9, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28065536/a-rare-case-of-epididymal-metastasis-after-radical-prostatectomy-detected-by-68ga-psma-pet-ct
#3
Giulia Polverari, Francesco Ceci, Tiziano Graziani, Cesare Cozzarini, Paolo Castellucci, Stefano Fanti
No abstract text is available yet for this article.
December 22, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28063603/prostate-specific-membrane-antigen-targeted-ligand-positron-emission-tomography-computed-tomography-and-immunohistochemical-findings-in-a-patient-with-synchronous-metastatic-penile-and-prostate-cancer
#4
Michael Froehner, Friederike Kuithan, Klaus Zöphel, Ulrike Heberling, Michael Laniado, Manfred P Wirth
A 68-year-old man presented with synchronous metastatic penile and prostate cancer. 68Ga-labeled prostate-specific membrane antigen-targeted ligand positron emission tomography/computed tomography (PSMA-PET/CT) revealed tracer uptake in inguinal, pelvic, and retroperitoneal metastases. Lymph node biopsies and immunohistochemical staining revealed that both cancers involved the lymph nodes and expressed PSMA. In the deposits of penile squamous cell carcinoma, PSMA expression was seen in tumor vessels and may explain the PSMA-PET/CT positivity of inguinal nodes involved in squamous cell carcinoma...
January 4, 2017: Urology
https://www.readbyqxmd.com/read/28062595/the-clinical-impact-of-additional-late-pet-ct-imaging-with-68ga-psma-11-hbed-cc-in-the-diagnosis-of-prostate-cancer
#5
Ali Afshar-Oromieh, Lars Peter Sattler, Walter Mier, Boris Hadaschik, Jürgen Debus, Tim Holland-Letz, Klaus Kopka, Uwe Haberkorn
PURPOSE: While Positron Emission Tomography/Computed Tomography (PET/CT) with (68)Ga-PSMA-11 in the diagnosis of prostate cancer (PCa) is routinely performed at 1h post injection (p.i.), later scans may be beneficial since most lesions present with higher uptake and contrast. This evaluation aimed to investigate the clinical impact of additional late (68)Ga-PSMA-11-PET/CT. METHODS: Between 2011 and 2016, 112 patients with PCa who received early (at 1h p.i.) and late (at 3h p...
January 6, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28045734/prostate-specific-membrane-antigen-pet-ct-uptake-in-lymph-nodes-with-active-sarcoidosis
#6
André Henrique Dias, Mikkel Holm Vendelbo, Kirsten Bouchelouche
We describe 2 cases of Ga-PSMA PET/CT in prostate cancer patients. Both cases demonstrated symmetrical bilateral involvement of mediastinal and hilar lymph nodes besides findings in relation with prostatic disease. In both cases, endobronchial ultrasound-guided biopsy showed that the involvement of the thoracic lymph nodes was caused by nonnecrotic granulomas compatible with sarcoidosis. The cases demonstrated that increased Ga-PSMA uptake can be seen in lymph nodes with active sarcoidosis, with images mimicking those well known from FDG PET/CT...
December 30, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28045729/68ga-psma-pet-ct-in-a-rare-case-of-metastatic-adenocarcinoma-prostate-presenting-as-numb-chin-syndrome
#7
Arun Sasikumar, Ajith Joy, M R A Pillai, Renuka Gopal, Boben Thomas
A 68-year-old man presented with right-side facial numbness. MRI showed an extra-axial mass infiltrating the right temporal bone. It was debulked surgically, and histopathology revealed metastatic adenocarcinoma. Ga PSMA PET/CT done in view of increased PSA levels and clinically suspicious hard lesion in prostate showed primary lesion in left side of prostate with metastases to the right temporal bone. Primary carcinoma of the prostate and metastases to the right temporal bone were proven histopathologically...
December 30, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28042330/comparison-of-68-ga-hbed-cc-psma-pet-ct-and-multiparametric-mri-for-gross-tumour-volume-detection-in-patients-with-primary-prostate-cancer-based-on-slice-by-slice-comparison-with-histopathology
#8
Constantinos Zamboglou, Vanessa Drendel, Cordula A Jilg, Hans C Rischke, Teresa I Beck, Wolfgang Schultze-Seemann, Tobias Krauss, Michael Mix, Florian Schiller, Ulrich Wetterauer, Martin Werner, Mathias Langer, Michael Bock, Philipp T Meyer, Anca L Grosu
PURPOSE: The exact detection and delineation of the intraprostatic tumour burden is crucial for treatment planning in primary prostate cancer (PCa). We compared (68)Ga-HBED-CC-PSMA PET/CT with multiparametric MRI (mpMRI) for diagnosis and tumour delineation in patients with primary PCa based on slice by slice correlation with histopathological reference material. METHODOLOGY: Seven patients with histopathologically proven primary PCa underwent (68)Ga-HBED-CC-PSMA PET/CT and MRI followed by radical prostatectomy...
2017: Theranostics
https://www.readbyqxmd.com/read/28040309/delineating-biochemical-failure-with-68-ga-psma-pet-following-definitive-external-beam-radiation-treatment-for-prostate-cancer
#9
George Hruby, Thomas Eade, Andrew Kneebone, Louise Emmett, Lesley Guo, Bao Ho, Ed Hsiao, Geoff Schembri, Julia Hunter, Carol Kwong
BACKGROUND AND PURPOSE: We investigated the role of (68)Ga-PSMA-PET (PSMA) to determine the location of disease recurrence in those with a rising PSA following definitive external beam radiation treatment (EBRT). MATERIALS AND METHODS: 538men were treated with image guided EBRT to a dose of 78 or 82Gy between 2007 and 2014. Patients at least 24months post EBRT with biochemical failure (nadir+2) underwent PSMA scanning. Local recurrence (LR) was defined as increased uptake within the prostate or seminal vesicles...
December 28, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28034291/radiopharmaceuticals-for-diagnosis-and-therapy-of-neuroendocrine-differentiated-prostate-cancer
#10
Giampiero Giovacchini, Elisabetta Giovannini, Mattia Riondato, Andrea Ciarmiello
Neuroendocrine differentiation of prostate cancer (PCa) is a relatively frequent event, generally understudied, that carries important prognostic information. It is most frequently observed during the advanced stages of disease, when PCa has lost its sensitivity to androgen deprivation therapy or to chemotherapy, moderate to diffuse bone metastatic spread dominates the imaging scenario and it is responsible for painful clinical symptomatology. However, evidences indicate that neuroendocrine differentiation is a progressive phenomenon that starts at the very early part of the pathogenesis of cancer transformation contributing to it...
December 29, 2016: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/28033225/cerebellar-metastases-from-prostate-cancer-on-68ga-psma-pet-ct
#11
Mico Chan, Edward Hsiao, Jennifer Turner
Ga prostate-specific membrane antigen PET/CT is increasingly used to evaluate extent of disease in prostate carcinoma. Parenchymal brain metastases originating from prostate cancer have highly variable imaging appearance. We present a 77-year-old man with cerebellar metastasis from prostate cancer showing focal uptake on prostate-specific membrane antigen PET/CT.
December 28, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28033223/incidental-detection-of-thyroid-metastases-from-renal-cell-carcinoma-using-68ga-psma-pet-ct-to-assess-prostate-cancer-recurrence
#12
Helle D Zacho, Julie B Nielsen, Katja Dettmann, Uwe Haberkorn, Lars J Petersen
Ga-PSMA PET/CT is increasingly used to assess prostate cancer. Avid Ga-PSMA uptake by thyroid cancer and renal cell carcinoma (RCC) has been reported in few cases. A 75-year-old man who received a diagnosis of RCC in 2006 and prostate cancer in 2009 presented with elevated prostate-specific antigen levels (0.7 ng/mL) following prostatectomy. Ga-PSMA PET/CT showed avid Ga-PSMA uptake in 1 pelvic and 1 retroperitoneal lymph node and focal Ga-PSMA accumulation in the thyroid. Excised retroperitoneal lymph node and thyroid tissues showed metastases from RCC, whereas the pelvic lymph node exhibited metastasis from prostate cancer...
December 28, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28033219/68ga-psma-hbed-uptake-on-cervicothoracic-stellate-ganglia-a-common-pitfall-on-pet-ct
#13
Mohsen Beheshti, Alireza Rezaee, Werner Langsteger
Ga-PSMA-HBED PET/CT showed promising results in staging and restaging of prostate cancer. However, nonspecific uptake has been reported in the celiac ganglia. In this case series, we showed faint radiotracer uptake on upper thoracic region in the location of cervicothoracic (stellate) ganglia. This ganglion is located anterior to the transverse process of C7 vertebra, inferior to subclavian artery, and superior to the neck of the first rib.
December 28, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28012435/estimation-of-radiation-dosimetry-for-68-ga-hbed-cc-psma-11-in-patients-with-suspected-recurrence-of-prostate-cancer
#14
Mark A Green, Jacob A Eitel, James W Fletcher, Carla J Mathias, Mark A Tann, Thomas Gardner, Michael O Koch, Wendy Territo, Heather Polson, Gary D Hutchins
INTRODUCTION: This study was performed to estimate the human radiation dosimetry for [(68)Ga]Ga-HBED-CC (PSMA-11) ((68)Ga PSMA-11). METHODS: Under an RDRC-approved research protocol, we evaluated the biodistribution and pharmacokinetics of (68)Ga PSMA-11 with serial PET imaging following intravenous administration to nine prostate cancer patients in whom clinical [(11)C]acetate PET/CT exams had been independently performed under Expanded Access IND 118,204. List-mode imaging was performed over the initial 0-10min post-injection with the pelvis in the field-of-view...
November 4, 2016: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28005153/-significance-of-psma-imaging-in-prostate-cancer
#15
C Gasch, C Düwel, K Kopka, C Kratochwil, M Vinsensia, M Eiber, T Maurer, U Haberkorn, B Hadaschik, F L Giesel
BACKGROUND: Prostate cancer (PCa) is one of the most common malignancies of men in developed countries. To improve clinical diagnostics of PCa, (68)Ga-PSMA-11 was recently introduced as a new PET tracer. (68)Ga-PSMA-11 is able to specifically bind to the prostate-specific membrane antigen (PSMA), which is upregulated on the surface of prostate cancer cells in most patients. OBJECTIVES: To analyse the current significance of (68)Ga-PSMA-11 PET imaging in prostate cancer in relation to staging of men with initial diagnosis, biochemical recurrence and metastatic disease...
December 22, 2016: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/27997426/subacute-cortical-infarct-showing-uptake-on-68ga-psma-pet-ct
#16
Mico Chan, Edward Hsiao
Ga prostate-specific membrane antigen (PSMA) PET/CT is increasingly used to evaluate extent of disease in prostate carcinoma. We present a case of subacute cortical cerebral infarct showing focal uptake on PSMA PET/CT. It is an important potential cause of false-positive uptake in this imaging cohort. The patient is an 85-year-old man with a background of nonbacterial thrombotic endocarditis and previous cerebrovascular events. He was referred for PSMA PET/CT for staging of high-risk prostate cancer.
December 16, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27997423/strong-pmsa-radioligand-uptake-by-rectal-carcinoma-who-put-the-s-in-psma
#17
Christian Stoykow, Sabine Huber-Schumacher, Nadja Almanasreh, Cordula Jilg, Juri Ruf
We present a case of a 71-year-old patient with newly diagnosed rectal adenocarcinoma and hepatic metastases. Restaging after chemotherapy revealed a good response of the rectal primary while liver metastases were progressive. As the patient also had a history of prostate cancer, a Ga-PSMA-HBED-CC PET/CT scan was performed to noninvasively further assess hepatic metastases. However, a definite differentiation between tumor entities was not possible because not only the liver metastases but also the rectal primary showed radioligand uptake (moderate and strong, respectively)...
December 16, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27997422/psma-expression-in-tumor-neovasculature-endothelial-cells-of-follicular-thyroid-adenoma-as-identified-by-molecular-imaging-using-68ga-psma-ligand-pet-ct
#18
Thorsten Derlin, Hans-Heinrich Kreipe, Udo Schumacher, Bisharah Soudah
The prostate-specific membrane antigen (PSMA) is expressed by both prostate cancer and other neoplasms. We report the case of a 65-year-old man with castration-resistant metastatic prostate cancer who underwent Ga-PSMA ligand PET/CT for restaging of disease. Ga-PSMA ligand accumulation was noted in a thyroid lesion, suspicious for thyroid malignancy on complementary ultrasound. Subsequent resection and histopathological analysis showed follicular thyroid adenoma with PSMA expression in tumor neovasculature endothelial cells, but not in thyroid epithelial cells...
December 16, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27994690/unusual-uptake-of-prostate-specific-tracer-68-ga-psma-hbed-cc-in-a-benign-thyroid-nodule
#19
Nishikant Avinash Damle, Madhavi Tripathi, Partha Sarathi Chakraborty, Manas Kumar Sahoo, Chandrasekhar Bal, Shipra Aggarwal, Geetanjali Arora, Praveen Kumar, Rajeev Kumar, Ravikant Gupta
(68)Ga-Prostate specific membrane antigen- N,N'-bis[2-hydroxy-5-(carboxyethyl)benzyl]ethylenediamine-N,N'-diacetic acid- positron emission tomography/computed tomography or 68 Ga- HBED-CC-PSMA PET/CT, popularly known as PSMA PET/CT, is able to detect a small volume of recurrent prostate carcinoma (PC) when there is a prostate specific antigen (PSA) rise on follow-up after prostatectomy or other definitive treatment for PC. The use of PSMA PET/CT in the initial staging in PC is uncertain at this time. Clinical studies are underway to define its exact role in the management of the disease...
December 2016: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27988802/local-recurrence-of-prostate-cancer-after-radical-prostatectomy-is-at-risk-to-be-missed-in-68-ga-psma-11-pet-of-pet-ct-and-pet-mri-comparison-with-mpmri-integrated-in-simultaneous-pet-mri
#20
Martin T Freitag, Jan P Radtke, Ali Afshar-Oromieh, Matthias C Roethke, Boris A Hadaschik, Martin Gleave, David Bonekamp, Klaus Kopka, Matthias Eder, Thorsten Heusser, Marc Kachelriess, Kathrin Wieczorek, Christos Sachpekidis, Paul Flechsig, Frederik Giesel, Markus Hohenfellner, Uwe Haberkorn, Heinz-Peter Schlemmer, A Dimitrakopoulou-Strauss
PURPOSE: The positron emission tomography (PET) tracer (68)Ga-PSMA-11, targeting the prostate-specific membrane antigen (PSMA), is rapidly excreted into the urinary tract. This leads to significant radioactivity in the bladder, which may limit the PET-detection of local recurrence (LR) of prostate cancer (PC) after radical prostatectomy (RP), developing in close proximity to the bladder. Here, we analyze if there is additional value of multi-parametric magnetic resonance imaging (mpMRI) compared to the (68)Ga-PSMA-11-PET-component of PET/CT or PET/MRI to detect LR...
December 17, 2016: European Journal of Nuclear Medicine and Molecular Imaging
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