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https://www.readbyqxmd.com/read/27827358/impact-of-mutational-profiles-on-response-of-primary-oestrogen-receptor-positive-breast-cancers-to-oestrogen-deprivation
#1
Pascal Gellert, Corrinne V Segal, Qiong Gao, Elena López-Knowles, Lesley-Ann Martin, Andrew Dodson, Tiandao Li, Christopher A Miller, Charles Lu, Elaine R Mardis, Alexa Gillman, James Morden, Manuela Graf, Kally Sidhu, Abigail Evans, Michael Shere, Christopher Holcombe, Stuart A McIntosh, Nigel Bundred, Anthony Skene, William Maxwell, John Robertson, Judith M Bliss, Ian Smith, Mitch Dowsett
Pre-surgical studies allow study of the relationship between mutations and response of oestrogen receptor-positive (ER+) breast cancer to aromatase inhibitors (AIs) but have been limited to small biopsies. Here in phase I of this study, we perform exome sequencing on baseline, surgical core-cuts and blood from 60 patients (40 AI treated, 20 controls). In poor responders (based on Ki67 change), we find significantly more somatic mutations than good responders. Subclones exclusive to baseline or surgical cores occur in ∼30% of tumours...
November 9, 2016: Nature Communications
https://www.readbyqxmd.com/read/27820907/box-jellyfish-alatina-alata-has-a-circumtropical-distribution
#2
Jonathan W Lawley, Cheryl Lewis Ames, Bastian Bentlage, Angel Yanagihara, Roger Goodwill, Ehsan Kayal, Kikiana Hurwitz, Allen G Collins
Species of the box jellyfish (Cubozoa) genus Alatina are notorious for their sting along the beaches of several localities of the Atlantic and Pacific. These species include Alatina alata on the Caribbean Island of Bonaire (the Netherlands), A. moseri in Hawaii, and A. mordens in Australia. Most cubozoans inhabit coastal waters, but Alatina is unusual in that specimens have also been collected in the open ocean at great depths. Alatina is notable in that populations form monthly aggregations for spermcast mating in conjunction with the lunar cycle...
October 2016: Biological Bulletin
https://www.readbyqxmd.com/read/27720514/do-changes-in-patellofemoral-joint-offset-lead-to-adverse-outcomes-in-total-knee-arthroplasty-with-patellar-resurfacing-a-radiographic-review
#3
Jacob Matz, James L Howard, David J Morden, Steven J MacDonald, Matthew G Teeter, Brent A Lanting
BACKGROUND: Patellofemoral joint biomechanics contribute to anterior knee pain, instability, and dysfunction following total knee arthroplasty (TKA). Information about specific factors leading to anterior knee pain and dysfunction is currently limited. Changes in patellofemoral joint offset (PFO) refers to a mismatch between the preoperative and postoperative anteroposterior geometry of the patellofemoral joint. It remains unclear whether these changes lead to adverse outcomes in TKA...
September 14, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/27716125/dars-a-phase-iii-randomised-multicentre-study-of-dysphagia-optimised-intensity-modulated-radiotherapy-do-imrt-versus-standard-intensity-modulated-radiotherapy-s-imrt-in-head-and-neck-cancer
#4
Imran Petkar, Keith Rooney, Justin W G Roe, Joanne M Patterson, David Bernstein, Justine M Tyler, Marie A Emson, James P Morden, Kathrin Mertens, Elizabeth Miles, Matthew Beasley, Tom Roques, Shreerang A Bhide, Kate L Newbold, Kevin J Harrington, Emma Hall, Christopher M Nutting
BACKGROUND: Persistent dysphagia following primary chemoradiation (CRT) for head and neck cancers can have a devastating impact on patients' quality of life. Single arm studies have shown that the dosimetric sparing of critical swallowing structures such as the pharyngeal constrictor muscle and supraglottic larynx can translate to better functional outcomes. However, there are no current randomised studies to confirm the benefits of such swallow sparing strategies. The aim of Dysphagia/Aspiration at risk structures (DARS) trial is to determine whether reducing the dose to the pharyngeal constrictors with dysphagia-optimised intensity- modulated radiotherapy (Do-IMRT) will lead to an improvement in long- term swallowing function without having any detrimental impact on disease-specific survival outcomes...
October 6, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27537876/population-genetics-of-the-endemic-hawaiian-species-chrysodracon-hawaiiensis-and-chrysodracon-auwahiensis-asparagaceae-insights-from-rapd-and-issr-variation
#5
Pei-Luen Lu, Mitsuko Yorkson, Clifford W Morden
The genus Chrysodracon has six endemic species in the Hawaii Islands. Chrysodracon hawaiiensis is endemic to Hawaii Island and was described as a distinct species in 1980. It was listed as an endangered species on the International Union for the Conservation of Nature and Natural Resources (IUCN) Red List in 1997. This woody plant species was, at one time, common in exposed dry forests, but it became very rare due to grazing pressure and human development. The tree species Chrysodracon auwahiensis (C. auwahiensis), endemic to Maui and Molokai, still has large adult populations in dry lands of the islands, but unfortunately no regeneration from seed has been reported in those areas for many years...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27402662/interventions-aimed-at-reducing-use-of-low-value-health-services-a-systematic-review
#6
Carrie H Colla, Alexander J Mainor, Courtney Hargreaves, Thomas Sequist, Nancy Morden
The effectiveness of different types of interventions to reduce low-value care has been insufficiently summarized to allow for translation to practice. This article systematically reviews the literature on the effectiveness of interventions to reduce low-value care and the quality of those studies. We found that multicomponent interventions addressing both patient and clinician roles in overuse have the greatest potential to reduce low-value care. Clinical decision support and performance feedback are promising strategies with a solid evidence base, and provider education yields changes by itself and when paired with other strategies...
July 8, 2016: Medical Care Research and Review: MCRR
https://www.readbyqxmd.com/read/27332619/state-legal-restrictions-and-prescription-opioid-use-among-disabled-adults
#7
Ellen Meara, Jill R Horwitz, Wilson Powell, Lynn McClelland, Weiping Zhou, A James O'Malley, Nancy E Morden
BACKGROUND: In response to rising rates of opioid abuse and overdose, U.S. states enacted laws to restrict the prescribing and dispensing of controlled substances. The effect of these laws on opioid use is unclear. METHODS: We tested associations between prescription-opioid receipt and state controlled-substances laws. Using Medicare administrative data for fee-for-service disabled beneficiaries 21 to 64 years of age who were alive throughout the calendar year (8...
July 7, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27266435/physician-perceptions-of-choosing-wisely-and-drivers-of-overuse
#8
Carrie H Colla, Elizabeth A Kinsella, Nancy E Morden, David J Meyers, Meredith B Rosenthal, Thomas D Sequist
OBJECTIVES: Little is known regarding physicians' views on health service overuse or their awareness of the American Board of Internal Medicine Foundation's Choosing Wisely campaign. Through the Survey on Overuse and Knowledge of Choosing Wisely, we assessed physician views on hypothesized drivers of overuse and Choosing Wisely. STUDY DESIGN: We designed the survey to investigate physicians' knowledge of, awareness of, and feelings toward Choosing Wisely, along with their concerns about malpractice, perception of patient demand, discomfort with uncertainty, and cost-consciousness...
May 2016: American Journal of Managed Care
https://www.readbyqxmd.com/read/27256931/orbitide-composition-of-the-flax-core-collection-fcc
#9
Peta-Gaye Gillian Burnett, Clara Marisa Olivia, Denis Paskal Okinyo-Owiti, Martin John Tarsisius Reaney
The flax (Linum usitatissimum L.) core collection (FCC) was regenerated in Saskatoon, Saskatchewan and Morden, Manitoba in 2009. Seed orbitide content and composition from successfully propagated plants of 391 accessions were analyzed using high-throughput analyses employing high-performance liquid chromatography (HPLC) with reverse-phase monolithic HPLC columns and diode array detection (HPLC-DAD). Seed from plants regenerated in Morden had comparatively higher orbitide content than those grown in Saskatoon...
June 29, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27114326/assessing-methods-for-dealing-with-treatment-switching-in-clinical-trials-a-follow-up-simulation-study
#10
Nicholas R Latimer, Keith R Abrams, Paul C Lambert, James P Morden, Michael J Crowther
When patients randomised to the control group of a randomised controlled trial are allowed to switch onto the experimental treatment, intention-to-treat analyses of the treatment effect are confounded because the separation of randomised groups is lost. Previous research has investigated statistical methods that aim to estimate the treatment effect that would have been observed had this treatment switching not occurred and has demonstrated their performance in a limited set of scenarios. Here, we investigate these methods in a new range of realistic scenarios, allowing conclusions to be made based upon a broader evidence base...
April 25, 2016: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/27074388/examination-of-factors-associated-with-use-rates-after-transition-from-a-universal-to-partial-motorcycle-helmet-use-law
#11
Brendan J Russo, Timothy P Barrette, Jeffery Morden, Peter T Savolainen, Timothy J Gates
OBJECTIVE: Motorcycle riders account for a disproportionately high number of traffic injuries and fatalities as compared with occupants of other vehicle types. While research has demonstrated the benefits of helmet use in preventing serious and fatal injuries in the event of a crash, helmet use has remained relatively stable in the United States where the most recent national estimates show a 64 percent use rate. Use rates have been markedly lower among those states that do not have a universal helmet law for all riders...
April 13, 2016: Traffic Injury Prevention
https://www.readbyqxmd.com/read/27049853/growth-of-hiv-exposed-uninfected-infants-in-the-first-6-months-of-life-in-south-africa-the-iedea-sa-collaboration
#12
Erna Morden, Karl-Günter Technau, Janet Giddy, Nicola Maxwell, Olivia Keiser, Mary-Ann Davies
BACKGROUND: HIV-exposed uninfected (HEU) infants are a growing population in sub-Saharan Africa especially with the increasing coverage of more effective prevention of mother-to-child transmission (PMTCT) antiretroviral therapy regimens. This study describes the characteristics of South African HEU infants, investigates factors impacting birth weight and assesses their growth within the first 28 weeks of life. METHODS: This is a retrospective cohort based on routine clinical data from two South African PMTCT programmes...
2016: PloS One
https://www.readbyqxmd.com/read/27046390/acute-skin-toxicity-associated-with-a-1-week-schedule-of-whole-breast-radiotherapy-compared-with-a-standard-3-week-regimen-delivered-in-the-uk-fast-forward-trial
#13
A Murray Brunt, Duncan Wheatley, John Yarnold, Navita Somaiah, Stephen Kelly, Adrian Harnett, Charlotte Coles, Andrew Goodman, Amit Bahl, Mark Churn, Rada Zotova, Mark Sydenham, Clare L Griffin, James P Morden, Judith M Bliss
BACKGROUND AND PURPOSE: FAST-Forward is a phase 3 clinical trial testing a 1-week course of whole breast radiotherapy against the UK standard 3-week regimen after primary surgery for early breast cancer. Two acute skin toxicity substudies were undertaken to test the safety of the test schedules with respect to early skin reactions. MATERIAL AND METHODS: Patients were randomly allocated to 40Gy/15 fractions (F)/3-weeks, 27Gy/5F/1-week or 26Gy/5F/1-week. Acute breast skin reactions were graded using RTOG (first substudy) and CTCAE criteria v4...
July 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27036195/heterogeneity-in-global-gene-expression-profiles-between-biopsy-specimens-taken-peri-surgically-from-primary-er-positive-breast-carcinomas
#14
Elena López-Knowles, Qiong Gao, Maggie Chon U Cheang, James Morden, Joel Parker, Lesley-Ann Martin, Isabel Pinhel, Fiona McNeill, Margaret Hills, Simone Detre, Maria Afentakis, Lila Zabaglo, Andrew Dodson, Anthony Skene, Chris Holcombe, John Robertson, Ian Smith, Judith M Bliss, Mitch Dowsett
BACKGROUND: Gene expression is widely used for the characterisation of breast cancers. Variability due to tissue heterogeneity or measurement error or systematic change due to peri-surgical procedures can affect measurements but is poorly documented. We studied the variability of global gene expression between core-cuts of primary ER+ breast cancers and the impact of delays to tissue stabilisation due to sample X-ray and of diagnostic core cutting. METHODS: Twenty-six paired core-cuts were taken immediately after tumour excision and up to 90 minutes delay due to sample X-ray; 57 paired core-cuts were taken at diagnosis and 2 weeks later at surgical excision...
2016: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/27001582/reply-to-s-kilickap-et-al-y-karakas-et-al-and-i-a-voutsadakis
#15
James P Morden, Rosalind A Eeles, Judith M Bliss
No abstract text is available yet for this article.
June 10, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/26994893/recovery-of-salivary-function-contralateral-parotid-sparing-intensity-modulated-radiotherapy-versus-bilateral-superficial-lobe-parotid-sparing-intensity-modulated-radiotherapy
#16
A B Miah, S L Gulliford, J Morden, K L Newbold, S A Bhide, S H Zaidi, E Hall, K J Harrington, C M Nutting
AIMS: To establish whether there is a difference in recovery of salivary function with bilateral superficial lobe parotid-sparing intensity-modulated radiotherapy (BSLPS-IMRT) versus contralateral parotid-sparing IMRT (CLPS-IMRT) in patients with locally advanced head and neck squamous cell cancers. MATERIALS AND METHODS: A dosimetric analysis was carried out on data from two studies in which patients received BSLPS-IMRT (PARSPORT II) or CLPS-IMRT (PARSPORT). Acute (National Cancer Institute, Common Terminology Criteria for adverse events - NCI CTCAEv3...
September 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/26974656/correction-seasonality-in-polyps-of-a-tropical-cubozoan-a-latina-nr-mordens
#17
(no author information available yet)
No abstract text is available yet for this article.
2016: PloS One
https://www.readbyqxmd.com/read/26940927/use-of-guideline-directed-medications-for-heart-failure-before-cardioverter-defibrillator-implantation
#18
Gregory A Roth, Jeanne E Poole, Rebecca Zaha, Weiping Zhou, Jonathan Skinner, Nancy E Morden
BACKGROUND: Guideline-directed medical therapy (GDMT) for heart failure with reduced ejection fraction (HFrEF) is recommended before primary prevention implantable cardioverter-defibrillator (ICD) placement. Adherence to this recommendation and associated outcomes are unknown. OBJECTIVES: This study examined the use of GDMT (≥1 prescription filled for both a renin-angiotensin inhibitor [RAI] and a heart failure-approved beta-blocker [HFBB]) within 90 days before primary prevention ICD placement in patients with HFrEF...
March 8, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/26894755/diabetes-pharmacotherapies-and-bladder-cancer-a-medicare-epidemiologic-study
#19
Todd A Mackenzie, Rebecca Zaha, Jeremy Smith, Margaret R Karagas, Nancy E Morden
OBJECTIVE: Patients with type II diabetes have an increased risk of bladder cancer and are commonly treated with thiazolidinediones and angiotensin receptor blockers (ARBs), which have been linked to cancer risk. We explored the relationship between use of one or both of these medication types and incident bladder cancer among diabetic patients (diabetics) enrolled in Medicare. RESEARCH DESIGN AND METHODS: We constructed both a prevalent and incident retrospective cohort of pharmacologically treated prevalent diabetics enrolled in a Medicare fee-for-service plan using inpatient, outpatient (2003-2011) and prescription (2006-2011) administrative data...
March 2016: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/26770680/exploring-patient-priorities-among-long-term-conditions-in-multimorbidity-a-qualitative-secondary-analysis
#20
Sudeh Cheraghi-Sohi, Andrew Morden, Peter Bower, Anne Kennedy, Anne Rogers, Jane Richardson, Tom Sanders, Fiona Stevenson, Bie N Ong
OBJECTIVE: A lack of agreement between health-care providers and patient priorities can impact the health-care provider-patient relationship, treatment concordance and potentially health outcomes. Evidence suggests that people living with multiple morbidities do prioritise among their long-term conditions. However, the evidence revealing the underlying reasons behind this prioritisation remains limited. Given the potential implications for day-to-day self-management activity and ultimately patient outcomes, this study aims to explore how and why people with multimorbidity prioritise some long-term conditions over others and what the potential implications may be for self-management activity, and in turn, suggest how such information may help clinicians negotiate the management of multimorbidity patients...
2013: SAGE Open Medicine
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