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https://www.readbyqxmd.com/read/28535663/up-regulation-of-rank-expression-via-erk1-2-by-insulin-contributes-to-the-enhancement-of-osteoclast-differentiation
#1
Ju Hee Oh, Na Kyung Lee
Despite the importance of the receptor activator of nuclear factor (NF)-kappaB ligand (RANKL)-RANK signaling mechanisms on osteoclast differentiation, little has been studied on how RANK expression is regulated or what regulates its expression during osteoclastogenesis. We show here that insulin signaling increases RANK expression, thus enhancing osteoclast differentiation by RANKL. Insulin stimulation induced RANK gene expression in time- and dose-dependent manners and insulin receptor shRNA completely abolished RANK expression induced by insulin in bone marrow-derived monocyte/ macrophage cells (BMMs)...
May 22, 2017: Molecules and Cells
https://www.readbyqxmd.com/read/28535646/-the-research-advances-in-the-relationship-between-visfatin-and-cancer
#2
W Y Tian, Y M Wang, Y F Zhang, F X Xue
Visfatin is a cytokine secreted by visceral adipose tissue, which plays an important role in obesity, diabetes, insulin resistance, atherosclerosis and polycystic ovarian syndrome. Additionally, visfatin is also involved in the metabolic syndrome-associated malignancies such as breast, colon, gastric and endometrial cancers. Visfatin inhibitor might be a potential antitumor therapeutic strategy for inhibiting the growth of many cancers.
May 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28535403/the-predictive-effect-of-inflammatory-markers-and-lipid-accumulation-product-index-on-clinical-symptoms-associated-with-polycystic-ovary-syndrome-in-nonobese-adolescents-and-younger-aged-women
#3
Esra Nur Tola, Serenat Eris Yalcin, Nadiye Dugan
OBJECTIVE(S): The aim of our study is to analyse the inflammatory markers and lipid accumulation product (LAP) index in nonobese adolescents and younger aged women with polycystic ovary syndrome (PCOS) compared with age and body mass index (BMI)-matched healthy controls and to determine whether the investigated parameters are potential markers for the etiopathogenesis of PCOS. We also aim to determine whether these inflammatory markers are predictive for developing some clinical implications, such as cardiovascular disease (CVD) and insulin resistance (IR), associated with PCOS...
May 15, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28535046/inhibitory-effect-of-piceatannol-on-tnf-%C3%AE-mediated-inflammation-and-insulin-resistance-in-3t3-l1-adipocytes
#4
Yanfang Li, Puyu Yang, Qimeng Chang, Jing Wang, Jie Liu, Yuan Lv, Thomas T Y Wang, Boyan Gao, Yaqiong Zhang, Liangli Lucy Yu
Piceatannol, a bioactive component in grapes and blueberry, was examined for its potential in decreasing the inflammatory activities in adipocytes using a co-cultured adipocytes and macrophages system, and suppressing TNF-α mediated inflammation and the related insulin resistance using a 3T3-L1 adipocytes model. Piceatannol treatment significantly reduced the release of inflammatory cytokines of TNF-α and MCP-1 in the co-cultured system and inhibited TNF-α induced expression of IL-6 and MCP-1 at both mRNA and protein levels in the 3T3-L1 adipocytes...
May 23, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28534852/effects-of-ketogenic-diets-on-cardiovascular-risk-factors-evidence-from-animal-and-human-studies
#5
REVIEW
Christophe Kosinski, François R Jornayvaz
The treatment of obesity and cardiovascular diseases is one of the most difficult and important challenges nowadays. Weight loss is frequently offered as a therapy and is aimed at improving some of the components of the metabolic syndrome. Among various diets, ketogenic diets, which are very low in carbohydrates and usually high in fats and/or proteins, have gained in popularity. Results regarding the impact of such diets on cardiovascular risk factors are controversial, both in animals and humans, but some improvements notably in obesity and type 2 diabetes have been described...
May 19, 2017: Nutrients
https://www.readbyqxmd.com/read/28534682/diabetic-ketoacidosis-a-common-debut-of-diabetes-among-african-americans-with-type-2-diabetes
#6
Priyathama Vellanki, Guillermo E Umpierrez
OBJECTIVE: More than half of African Americans (AA) with a new diagnosis of diabetic ketoacidosis have clinical and metabolic features of type 2 diabetes during follow-up. This particular presentation of diabetes has been termed as ketosis-prone type 2 diabetes (KPDM) or atypical diabetes. METHODS: We review the epidemiology, diagnosis, pathophysiology and acute and long-term management of AA with KPDM and compare these similarities to patients with type 2 diabetes...
May 23, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28534431/ameliorating-effect-of-anti-alzheimer-s-drugs-on-the-bidirectional-association-between-type-2-diabetes-mellitus-and-alzheimer-s-disease
#7
Amira S Ahmed, Rehab M Elgharabawy, Amal H Al-Najjar
Mild to severe forms of nervous system damage were exhibited by approximately 60-70% of diabetics. It is important to understand the association between type 2 diabetes mellitus and Alzheimer's disease. The aim of the present work is to understand the bidirectional association between type 2 diabetes and Alzheimer's disease pathogenesis, that was monitored by glycaemic status, lipid profile, amyloid beta 40 and 42 (Aβ40 and Aβ42), C-reactive protein, total creatine kinase, total lactate dehydrogenase, D-dimer and magnesium measurements, to assess the association between theses biochemical markers and each other, to estimate the possibility of utilizing the amyloid beta as biochemical marker of T2D in Alzheimer's patients, and to evaluate the effect of piracetam and memantine drugs on diabetes mellitus...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28534323/-era-of-enhanced-recovery-after-surgery-and-robotic-gastric-cancer-surgery
#8
Yanbing Zhou
Enhanced recovery after surgery (ERAS) has been rapidly developing by combining several techniques with evidence-based adjustments, including preoperative education, preoperative carbohydrate loading, epidural or regional anesthesia, early initiation of enteral nutrition, ambulation and multi-modal pain management. The core part of ERAS is to reduce and reverse surgical stress and therefore greatly improve clinical outcome. Under the guidance of ERAS, perioperative management of robotic gastric cancer operation should follow the basic principles of ERAS and clinical pathway to maximize the advantages of the robotic surgery...
May 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28534013/serum-from-pregnant-women-with-gestational-diabetes-mellitus-increases-the-expression-of-fabp4-mrna-in-primary-subcutaneous-human-pre-adipocytes
#9
Lan Li, Se Jin Lee, Song Yi Kook, Tae Gyu Ahn, Ji Yeon Lee, Jong Yun Hwang
OBJECTIVE: Gestational diabetes mellitus (GDM) is defined as glucose intolerance first detected during pregnancy. It can result in pregnancy complications such as birth injury, stillbirth. Fatty acid-binding protein 4 (FABP4), found in adipose tissue, is associated with insulin resistance, and type 2 diabetes. The aim of this study was to investigate whether FABP4 in the placenta and decidua of pregnant women with GDM is higher than that in normal pregnant women, and whether serum from pregnant women with GDM may cause adipocytes to secrete more FABP4 than does serum from a normal pregnant group...
May 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28533294/type-2-diabetes-demystifying-the-global-epidemic
#10
Ranjit Unnikrishnan, Rajendra Pradeepa, Shashank R Joshi, Viswanathan Mohan
Type 2 diabetes (T2D) has attained the status of a global pandemic, spreading from affluent industrialized nations to the emerging economies of Asia, Latin America, and Africa. There is significant global variation in susceptibility to T2D, with Pacific Islanders, Asian Indians, and Native Americans being considerably more prone to develop the disorder. Although genetic factors may play a part, the rapidity with which diabetes prevalence has risen among these populations reflects the far-ranging and rapid socioeconomic changes to which they have been exposed over the past few decades...
June 2017: Diabetes
https://www.readbyqxmd.com/read/28533226/igf1r-protein-expression-is-not-associated-with-differential-benefit-to-concurrent-trastuzumab-in-early-stage-her2-breast-cancer-from-the-north-central-cancer-treatment-group-alliance-adjuvant-trastuzumab-trial-n9831
#11
Monica M Reinholz, Beiyun Chen, Amylou C Dueck, Kathleen Tenner, Karla Ballman, Darren Riehle, Robert B Jenkins, Xochiquetzal J Geiger, Ann E McCullough, Edith A Perez
Background: Preclinical evidence indicates that increased insulin-like growth factor receptor-1 (IGF1R) signaling interferes with the action of trastuzumab suggesting a possible mechanism of trastuzumab resistance. Thus, we evaluated IGF1R prevalence, relationship with demographic data, and association with disease-free survival (DFS) of patients randomized to chemotherapy alone (Arm A) or chemotherapy with sequential (Arm B) or concurrent trastuzumab (Arm C) in the prospective phase III HER2(+) adjuvant N9831 trial...
May 22, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28533215/inhibition-of-hdac3-prevents-diabetic-cardiomyopathy-in-ove26-mice-via-epigenetic-regulation-of-dusp5-erk1-2-pathway
#12
Zheng Xu, Qian Tong, Zhiguo Zhang, Shudong Wang, Yang Zheng, Qiuju Liu, Lingbo Qian, Shao-Yu Chen, Jian Sun, Lu Cai
Inhibition of total histone deacetylases (HDACs) was phenomenally associated with the prevention of diabetic cardiomyopathy (DCM). However, which specific HDAC plays the key role in DCM remains unclear. The present study was designed to determine whether DCM can be prevented by specific inhibition of HDAC3 and to elucidate the mechanisms by which inhibition of HDAC3 prevent DCM. Type 1 diabetes OVE26 and age-matched wild-type mice were given the selective HDAC3 inhibitor RGFP966 or vehicle for 3 months. These mice were then sacrificed immediately or 3 months later for cardiac function and pathological examination...
May 22, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28532855/long-term-influence-of-prenatal-high-sucrose-intake-on-learning-and-memory-of-aged-rat-offspring-with-oxidative-stress-and-disruptions-in-nmdars-wnt-signaling-in-hippocampus
#13
Axin He, Yingying Zhang, Lingjun Li, Xueqin Feng, Bin Wei, Di Zhu, Yanping Liu, Lei Wu, Lubo Zhang, Zhice Xu, Miao Sun
Maternal over-nutrition may increase risks of various diseases in the offspring. Our recent work demonstrated that prenatal high sucrose (HS) could impair spatial acquisitionin the adolescentoffspringrats. This study investigated whether prenatal HS has a long-term impact on cognitive capabilities in the aged offspring rats. The aged HS offspring showed impaired glucose tolerance, significantly increased fasting insulin and insulin resistance index, with unchanged plasma glucose. In the navigation test, the aged HS offspring exhibited longer escape latency and longer swimming path length to the platform...
May 19, 2017: Brain Research
https://www.readbyqxmd.com/read/28532220/the-adipokine-tartrate-resistant-acid-phosphatase-5a-in-serum-correlates-to-adipose-tissue-expansion-in-obesity
#14
Christina Patlaka, Laia Mira Pascual, Staffan Paulie, Anni-Frid Henriksson, Peter Arner, Pernilla Lång, Göran Andersson
PURPOSE: Tartrate resistant acid phosphatase (TRAP) exists as two isoforms, 5a and 5b. TRAP 5a is elevated in adipose tissue of obese women, interacts with pre-adipocytes and is linked to insulin-sensitive hyperplastic obesity when overexpressed in mice. The aim of this study was to investigate the relation between serum TRAP 5a, adiposity indices and metabolic syndrome risk markers in lean and obese women, using a newly developed TRAP 5a-specific ELISA. MATERIALS AND METHODS: A TRAP 5a sandwich ELISA was optimized using TRAP 5a-specific monoclonal antibodies and tested in sera of healthy males...
May 22, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28531788/association-of-dietary-factors-with-severity-of-coronary-artery-disease
#15
Namita Mahalle, M K Garg, S S Naik, M V Kulkarni
BACKGROUND: Cardiovascular disease has taken epidemic proportions during past decades. Cardiovascular risk factors contribute to progression of coronary lesions, worsening the patient's prognosis. This study was planned to analyze the association of dietary factors with severity of coronary artery disease (CAD) in Indian patients. METHODS: Three hundred patients with known coronary disease above the age of 25 years were included in this study. Blood samples were collected for biochemical markers...
October 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28531589/investigation-of-the-relationship-between-obesity-insulin-resistance-and-vitamin-d-insufficiency-in-prepubertal-school-aged-children
#16
Christina Filippou, George Moschonis, Anna Katsadoura, Katerina Sarapi, Yannis Μanios
No abstract text is available yet for this article.
June 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28531393/the-rs10401670-variant-in-resistin-gene-improved-insulin-resistance-response-and-metabolic-parameters-secondaries-to-weight-loss-after-a-hypocaloric-diet
#17
Daniel Antonio de Luis, Rocío Aller, Olatz Izaola, David Primo, R Bachiller
BACKGROUND: The SNP 3'UTR C/T (rs10401670), it is a polymorphism that has been associated with diabetes mellitus and it has been scarcely studied before. As far as we know, no studies on interaction among diet intervention, rs10401670 variant of RETN and metabolic response has been realized. OBJECTIVE: Our aim was to analyze the effects of the rs10401670 RETN gene polymorphism on insulin resistance response and metabolic changes secondary to weight loss after 3 months of a hypocaloric diet in adults obese patients without diabetes mellitus...
August 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28531286/is-foetal-hyperexposure-to-androgens-a-cause-of-pcos
#18
Panagiota Filippou, Roy Homburg
BACKGROUND: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy affecting reproductive-aged women. The pathophysiology of this syndrome is still not completely understood but recent evidence suggests that the intra-uterine environment may be a key factor in the pathogenesis of PCOS, in particular, hyperexposure of the foetus to androgens. High concentrations of maternal serum testosterone during pregnancy have been shown to influence behaviour during childhood, the prevalence of autism disorders and anti-Mullerian hormone (AMH) concentrations in adolescence...
May 20, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/28531120/antidiabetic-effects-of-tea
#19
REVIEW
Qiu-Yue Fu, Qing-Sheng Li, Xiao-Ming Lin, Ru-Ying Qiao, Rui Yang, Xu-Min Li, Zhan-Bo Dong, Li-Ping Xiang, Xin-Qiang Zheng, Jian-Liang Lu, Cong-Bo Yuan, Jian-Hui Ye, Yue-Rong Liang
Diabetes mellitus (DM) is a chronic endocrine disease resulted from insulin secretory defect or insulin resistance and it is a leading cause of death around the world. The care of DM patients consumes a huge budget due to the high frequency of consultations and long hospitalizations, making DM a serious threat to both human health and global economies. Tea contains abundant polyphenols and caffeine which showed antidiabetic activity, so the development of antidiabetic medications from tea and its extracts is increasingly receiving attention...
May 20, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28531113/retrospective-evaluation-of-metformin-and-or-metformin-plus-a-new-polysaccharide-complex-in-treating-severe-hyperinsulinism-and-insulin-resistance-in-obese-children-and-adolescents-with-metabolic-syndrome
#20
Stefano Stagi, Franco Ricci, Martina Bianconi, Maria Amina Sammarco, Giovanna Municchi, Sonia Toni, Lorenzo Lenzi, Alberto Verrotti, Maurizio de Martino
Background: Pharmacological treatment of obesity and glucose-insulin metabolism disorders in children may be more difficult than in adults. Thus, we evaluate the effects of metformin in comparison with metformin plus a polysaccharide complex (Policaptil Gel Retard(®), PGR) on body weight and metabolic parameters in obese children and adolescents with metabolic syndrome (MetS). Patients and methods: We retrospectively collected 129 children and adolescents (67 girls, 62 boys; median age 12.6 years) treated for a minimum of two years with metformin and low glycemic index (LGI) diet...
May 20, 2017: Nutrients
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