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Adenomas pituitary

Hun Ho Park, Eui Hyun Kim, Cheol Ryong Ku, Eun Jig Lee, Sun Ho Kim
OBJECTIVE: Cavernous sinus (CS) invasion is an unfavorable factor hindering remission of growth hormone (GH)-secreting pituitary adenomas. However, few data exist on aggressive surgical resection. The authors investigate the role of CS exploration for GH-secreting pituitary adenomas with CS invasion. METHODS: We classified 132 patients with GH-secreting pituitary adenomas invading CS into 4 groups. The patients underwent surgery using a microsurgical transsphenoidal approach (TSA) with assistance of an endoscope...
June 12, 2018: World Neurosurgery
Himanshu Suri, Carrie Dougherty
PURPOSE OF REVIEW: This article provides an overview of headache in the setting of pituitary adenoma. The purpose of this article is to educate providers on the association, possible pathophysiology, and the clinical presentation of headache in pituitary tumor. RECENT FINDINGS: Recent prospective evaluations indicate that risk factors for development of headache in the setting of pituitary adenoma include highly proliferative tumors, cavernous sinus invasion, and personal or family history of headache...
June 15, 2018: Current Pain and Headache Reports
Liverana Lauretti, Quintino Giorgio D'Alessandris, Mario Rigante, Luca Ricciardi, Pier Paolo Mattogno, Alessandro Olivi
BACKGROUND: In transsphenoidal endoscopic cranial base surgery, a precise navigational support may be crucial. This is particularly evident in case of tumors extending to the parasellar region or in recurrent tumors whereas the normal anatomy has been altered by previous surgery/radiotherapy. METHODS: Previous unsatisfactory experiences with a variety of navigation techniques in this type of surgery, encouraged us to perform an endoscopic endonasal approach with an OArm® (Medtronic, Inc...
June 11, 2018: World Neurosurgery
Mohammad Taghvaei, Seyed Mousa Sadrehosseini, Javad Behjati Ardakani, Manouchehr Nakhjavani, Mehdi Zeinalizadeh
PURPOSE: Endoscopic endonasal approach has recently become an acceptable option for resection of all pituitary adenomas. We assessed biochemical outcome of endoscopic endonasal surgery in growth hormone (GH) secreting adenomas including remission rate, predictors of remission and associated complications. METHODS: Sixty eight consecutive patients with acromegaly who underwent endoscopic endonasal surgery have been analyzed prospectively. Tumors were classified according to the size, Knosp score and Hardy-Wilson classifications...
June 11, 2018: World Neurosurgery
Jiaqi Li, Huiwen Tan, Juan Huang, Dan Luo, Ying Tang, Ruichao Yu, Hui Huang
RATIONALE: Thyrotropin-secreting adenoma (TSHoma) is rare. Even though the thyrotoxicosis is mild in patients with TSHoma, it is still a rare cause of arrhythmia, ignore of mild disfunction of thyroid function of TSHoma can lead to the delayed diagnosis of pituitary tumor or leading to recurring of complications. Graves' disease is an auto-immue endocrinological disorder. Association of TSHoma and Graves's disease is extremely rare. Coexistence of these two diseases made the diagnosis and treatment complicated...
June 2018: Medicine (Baltimore)
Shi-Yu Feng, Tao Zhou, Zheng-Hui Sun, Bo Bu, Jin-Li Jiang
The aim of the study was to explore anterior interhemispheric approach microsurgery for removing large sellar region tumors.A total of 118 patients with large sellar region tumors were treated with the anterior interhemispheric approach microsurgery. There were 58 craniopharyngioma, 37 pituitary adenoma, 5 hypothalamic glioma, 7 meningioma, and 11 other tumors cases. The maximal tumor diameter ranged from 3.0 to 8.2 cm, with a mean diameter of 4.3 cm. Diabetes insipidus and fluid and electrolyte imbalance were timely controlled after surgery...
June 2018: Medicine (Baltimore)
Justine C R Shotton, William S M Justice, Francisco J Salguero, Alan Stevens, Barbara Bacci
  Pituitary pars intermedia dysfunction (PPID), also known as equine Cushing's disease, is widely reported in middle-aged to older domestic equids but to date reported in only one nondomestic equid, the onager ( Equus hemionus onager). This case series reports clinical, hematological, and pathological findings consistent with PPID in two further equid species: one Chapman's zebra ( Equus quagga chapmani) and five Przewalski's horses ( Equus ferus przewalskii). The case series reports basal adrenocorticotropic hormone (ACTH) testing as a method to diagnose and monitor PPID in zoological equids and the use of pergolide mesylate to reduce basal ACTH concentration and reduce clinical signs associated with PPID...
June 2018: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
Ashutosh Rai, B D Radotra, K K Mukherjee, S K Gupta, Pinaki Dutta
Here we describe data of a comprehensive phosphoproteomic evaluation of 20 non-functioning pituitary adenomas (NFPAs). Peptides from 20 tumor samples were enriched with TiO2 beads and fractioned using bRPLC and subjected to high throughput LC-MS/MS-Orbitrap Fusion™ Tribrid™ Mass Spectrometer for analysis. Upto 5 precursor ions were selected for MS/MS analysis. Data was analyzed using MASCOT and SEQUEST. Bioinformatics tools Phosphosite Plus, Gene Ontology, DAVID, and KEGG were used to determine the biological significance of identified phosphoproteins...
June 2018: Data in Brief
Michael Karsy, Christian A Bowers, Jonathan Scoville, Bornali Kundu, Mohammed Atef, J Michael Gee, Jian Guan, William T Couldwell
BACKGROUND: Pituitary adenomas are among the most common primary brain tumors. Recently, overlapping surgery has been curbed in many institutions because of the suggestion there might be more significant adverse events, despite several studies showing that complication rates are equivalent. OBJECTIVE: To assess complications and costs associated with overlapping surgery during the transsphenoidal resection of pituitary adenomas. METHODS: A single-center, retrospective cohort study was performed to evaluate the cases of patients who underwent a transsphenoidal approach for pituitary tumor resection...
June 12, 2018: Neurosurgery
David J Eaton, Jonathan Lee, Rushil Patel, Antony E Millin, Ian Paddick, Christopher Walker
PURPOSE: Stereotactic radiosurgery (SRS) is strongly indicated for treatment of surgically inaccessible benign brain tumors. Various treatment platforms are available, but few comparisons have included multiple centers. As part of a national commissioning program, benchmark planning cases were completed by all clinical centers in the region. METHODS AND MATERIALS: Four benign cases were provided, with images and structures predelineated, including intracanalicular vestibular schwannoma (VS), larger VS, skull base meningioma, and secreting pituitary adenoma...
February 16, 2018: Practical Radiation Oncology
Lin Lu, Yu Yue Zhao, Hong Bo Yang, Xin Lun Tian, Zuo Jun Xu, Zhao Lin Lu
BACKGROUND: Patients with Cushing's disease (CD) with hypercortisolism have an increased risk of opportunistic infection. However, most CD patients exposed to infections are diagnostic latency, leading to a poor prognosis. METHODS: Six patients in our hospital and an additional six patients in the literature were included in this study. Clinical information of CD patients with pulmonary Cryptococcus neoformans are reviewed. RESULTS: The average baseline total cortisol and ACTH in serum at 8 am of all the patients was 44...
June 5, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
Juan Pablo Petiti, Liliana Del Valle Sosa, Florencia Picech, Gabriela Deisi Moyano Crespo, Jean Zander Arevalo Rojas, Pablo Anibal Pérez, Carolina Beatriz Guido, Carolina Leimgruber, María Eugenia Sabatino, Pedro Emilio García, Verónica Bengió, Francisco Roque Papalini, Paula Estario, Maria Celina Bernhardt, Marcos Villarreal, Silvina Gutiérrez, Ana Lucía De Paul, Jorge Humberto Mukdsi, Alicia I Torres
In pituitary adenomas, early recurrences and resistance to conventional pharmacotherapies are common, but the mechanisms involved are still not understood. The high expression of epidermal growth factor receptor 2 (HER2)/extracellular signal-regulated kinase (ERK1/2) signal observed in human pituitary adenomas, together with the low levels of the antimitogenic transforming growth factor beta receptor 2 (TBR2), encouraged us to evaluate the effect of the specific HER2 inhibition with trastuzumab on experimental pituitary tumor cell growth and its effect on the antiproliferative response to TGFB1...
June 6, 2018: Endocrine-related Cancer
B Voellger, N Waldt, Rosita Rupa, E Kirches, O Melhem, H-J Ochel, C Mawrin, R Firsching
OBJECTIVE: Resveratrol and radiation decrease viability in various tumor cells. This study aims to investigate combined effects of resveratrol and radiation on viability, induction of apoptosis and necrosis, and expression of apoptosis modulators in rodent GH3 and TtT/GF pituitary adenoma cells in vitro. METHODS: Cells were incubated with 10-100 µM resveratrol. Medium and medium with ethanol served as controls. After 2 h, cells were irradiated with 0-5 Gray (Gy) and further incubated for 48-72 h...
June 5, 2018: Journal of Neuro-oncology
Xiaopeng Guo, Lu Gao, Zihao Wang, Chenzhe Feng, Bing Xing
BACKGROUND: Many articles have been published on pituitary adenomas. Bibliometric analyses are helpful for determining the most impactful studies within a field. OBJECTIVE: To identify the top 100 most-cited articles on pituitary adenomas using the bibliometric analysis method. METHODS: We searched the Thomson Reuters Web of Science on March 31, 2018. Articles were listed in descending order by the total citation (TC) number, and the most-cited articles on pituitary adenomas were identified and analyzed...
June 2, 2018: World Neurosurgery
Chikezie Ikechukwu Eseonu, Karim ReFaey, Oscar Garcia, Roberto Salvatori, Alfredo Quinones-Hinojosa
Objective  This study presents a comparative analysis of cost efficacy between the microscopic and endoscopic transsphenoidal approaches, evaluating neurological outcome, extent of resection (EOR), and inpatient hospital costs. Design  This study was a retrospective chart review. Setting  This study was conducted at a tertiary care center. Participants  The study group consisted of 68 patients with transsphenoidal surgeries between January 2007 and January 2014. Main Outcome Measures  Two-sample t -tests and Pearson's chi-square test evaluated inpatient costs, quality-adjusted life years (QALYs), volumetric EOR, and neurological outcomes...
April 2018: Journal of Neurological Surgery. Part B, Skull Base
Abdulrazag M Ajlan, Sarah Bin Abdulqader, Achal S Achrol, Yousef Aljamaan, Abdullah H Feroze, Laurence Katznelson, Griffith R Harsh
Objectives  Pituitary adenoma (PA), among the most commonly encountered sellar pathologies, accounts for 10% of primary intracranial tumors. The reported incidence of postoperative diabetes insipidus (DI) is highly variable. In this study, we report our experience with DI following endoscopic transsphenoidal surgery (TSS) for PAs, elucidating the risk factors of postoperative DI, the likelihood of long-term DI, and the impact of DI on the length of stay (LOS). Methods  The study included 178 patients who underwent endoscopic resection of PAs...
April 2018: Journal of Neurological Surgery. Part B, Skull Base
Amir Humza Sohail, Umar Farooq Bhatti, Najmul Islam
Tuberculosis rarely involves the hypothalamo-pituitary region and constitutes only 1% of the lesions involving the sellar and/or suprasellar region. Coleman and Meredith first reported pituitary tuberculosis in 1940, and only a handful of cases have been reported ever since. It may manifest as a chiasmal syndrome due to compression of the optic chiasm or as hypopituitarism due to pituitary destruction. It has a characteristic radiological appearance and can mimic a pituitary adenoma. Diagnostic procedures, such as trans-sphenoidal biopsy, are crucial for accurate diagnosis...
June 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Asaka Sato, Yasushi Hara
PURPOSE: To evaluate the protein expression of somatostatin receptor (SSTR) 2, SSTR5 and dopamine D2 receptor (DA2R)-targets of somatostatin analogs and dopamine agonists-in normal canine pituitary and canine adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas. METHODS: Six normal canine pituitary glands and 14 canine ACTH-secreting pituitary adenoma cases were included in this study. The protein expression of SSTR2, SSTR5 and DA2R was determined by double-label immunofluorescence staining of these receptors and ACTH...
May 4, 2018: Research in Veterinary Science
E R Laws, D L Penn, C S Repetti
BACKGROUND: Pituitary tumors are common lesions, and they represent the second most frequent primary brain tumor. Their classification has undergone several changes over time. The World Health Organization conducts periodic expert review/consensus meetings and publishes the results as recommendations for changes in classification, based on advances in molecular and genetic advances. This paper summarizes the results of the 2017 WHO Classification, which recommends several important changes...
June 1, 2018: Journal of Endocrinological Investigation
Salma H Hussein, Tayba S Wahedi, Naji Al Johani, Yasser A Hakami, Kamal Alzahrani, Mussa H AlMalki
PURPOSE: Pituitary tumours are slowly progressing tumours, mostly benign, with a reported global prevalence of 16.7% (22.5% in radiologic studies and 14.4% in autopsy studies). Clinical and epidemiological data on pituitary adenomas in Saudi Arabia are lacking. We aimed to utilise our database variables to determine clinical and epidemiological characteristics as well as treatment outcomes of pituitary tumours among Saudi patients. METHODS: This retrospective study was conducted in King Fahad Medical City, Riyadh, Saudi Arabia, in patients with pituitary tumours...
May 7, 2018: Hormones: International Journal of Endocrinology and Metabolism
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