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Adenomas pituitary

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https://www.readbyqxmd.com/read/29239034/succinate-dehydrogenase-sdh-deficient-neoplasia
#1
REVIEW
Anthony J Gill
The succinate dehydrogenase (SDH) complex is a key respiratory enzyme composed of four subunits: SDHA, SDHB, SDHC and SDHD. Remarkably, immunohistochemistry for SDHB becomes negative whenever there is bi-alleic inactivation of any component of SDH, which is very rare in the absence of syndromic disease. Therefore, loss of SDHB immunohistochemistry serves as a marker of syndromic disease, usually germline mutation of one of the SDH subunits. Tumours which show loss of SDHB expression are termed succinate dehydrogenase-deficient...
January 2018: Histopathology
https://www.readbyqxmd.com/read/29239033/what-s-new-in-pituitary-pathology
#2
REVIEW
Sylvia L Asa, Ozgur Mete
The increasing recognition of pituitary disorders and their impact on quality of life and longevity has made understanding of this small gland a subject of paramount importance. Pituitary pathology has seen many significant studies that indicate progress in identification and classification of pituitary lesions, as well as improved management strategies for patients. In this review, we outline six major areas of advances: (i) changes in terminology from 'adenoma' to 'pituitary neuroendocrine tumour'; (ii) reclassification of hormone-negative tumours based on transcription factor expression that defines lineage; (iii) updates in new pathogenetic mechanisms, including those that underlie rare lesions such as X-LAG and pituitary blastoma; (iv) clarification of hypophysitis due to immunotherapy, xanthomatous hypophysitis due to rupture of a Rathke's cleft cyst and IgG4 disease as the cause of inflammatory pseudotumour; (v) the consolidation of pituicytoma variants, including spindle cell oncocytoma and granular cell tumour based on thyroid transcription factor-1 (TTF-1) reactivity; and (vi) the pathogenetic mechanisms that distinguish papillary from adamantinomatous craniopharyngioma...
January 2018: Histopathology
https://www.readbyqxmd.com/read/29238923/endoscopic-therapy-and-curative-effect-in-pituitary-adenoma-patients-complicated-by-acromegalic-cardiomyopathy
#3
Heping Zhou, Zhengjiang Zha, Xiangdong Li, Xinsheng Chen, Jing Wang, Zhongzhou Su
The study aimed to retrospectively analyze the clinical characteristics of patients with pituitary adenomas complicated by acromegalic cardiomyopathy and to evaluate the effect of endoscopic surgery. Eighty-six pituitary adenoma patients complicated by acromegalic cardiomyopathy who were treated with endoscopic surgery in the First Affiliated Hospital of Soochow University from January 2010 to December 2016 were enrolled. We noted patient clinical characteristics and explored the relationships with surgical treatment...
December 13, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/29236218/the-dangers-of-the-head-down-position-in-patients-with-untreated-pituitary-macroadenomas-case-series-and-review-of-literature
#4
Satoshi Kiyofuji, Avital Perry, Christopher S Graffeo, Caterina Giannini, Michael J Link
PURPOSE: Cavernous sinus syndrome is a rare phenomenon, characterized by simultaneous neuropathies of cranial nerves III-VI. Various pathological processes have been reported as precipitating etiologies, including infection, inflammation, vascular lesions, and neoplasms. PURPOSE: We report a unique case series of cavernous sinus syndrome attributable to prolonged Trendelenburg or prone positioning during non-cranial procedures and review the pertinent literature to enlighten on this rare but catastrophic phenomenon...
December 13, 2017: Pituitary
https://www.readbyqxmd.com/read/29235490/fibroblasts-play-a-potential-role-in-bone-destruction-via-osteopontin-related-caldesmon-expression-and-polymerization-in-human-non-functioning-pituitary-adenomas
#5
Li-Yang Zhang, Xiao-Lu Ge, Zheng Li, Yong-Jian Tang, Yuan-Yuan Xiong, Xue-Jun Li, Jin-Fang Liu, Si-Yi Wanggou, Chun-Tao Li, Kui Yang, Xin Chen, Zhong-Liang Hu, Yun-Sheng Liu, Zhi-Xiong Liu
Non-functioning pituitary adenomas (NFPAs) are the most frequent pituitary tumors. The elucidation of the mechanisms of aggressive NFPAs in bone destruction is required in order to guide the clinical diagnosis and treatment of NFPAs. In the present study, we investigated the differential proteomics of fibroblasts isolated from clinical specimens of NFPAs with or without bone destruction. Proteomic analysis revealed a group of molecules associated with cytoskeleton organization, including caldesmon, were differentially expressed between fibroblasts isolated from bone destruction NFPAs (BD-NFPAs) and fibroblasts isolated from non-bone destruction NFPAs (NBD-NFPAs)...
December 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29229338/delayed-occurrence-of-diabetes-insipidus-following-transsphenoidal-surgery-with-radiological-evaluation-of-the-pituitary-stalk-on-magnetic-resonance-imaging
#6
Yasuhiko Hayashi, Yasuhiro Aida, Yasuo Sasagawa, Masahiro Oishi, Daisuke Kita, Osamu Tachibana, Fumiaki Ueda, Mitsutoshi Nakada
INTRODUCTION: Diabetes insipidus (DI) is a major complication of transsphenoidal surgery (TSS). DI usually occurs within a couple of days after TSS. Delayed occurrence of postoperative DI is rarely observed and its developing mechanisms remain unknown. Methods Six patients were identified as having postoperative delayed DI, which was defined as DI that first occurred two or more weeks after TSS. They consisted of one male and five females, and their mean age was 38.3 (range: 10-76) years...
December 8, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29228199/new-neoplasm-during-gh-replacement-in-adults-with-pituitary-deficiency-following-malignancy-a-kims-analysis
#7
Katarzyna Krzyzanowska-Mittermayer, Anders F Mattsson, Dominique Maiter, Ulla Feldt-Rasmussen, Cecilia Camacho-Hübner, Anton Luger, Roger Abs
Context: Data on the association between growth hormone (GH) replacement in patients with GH deficiency (GHD) after malignancies and new neoplasms show conflicting results. Objective: To clarify the incidence of new malignant neoplasm in childhood (CO) and adult-onset (AO) adult cancer survivors (CS). Design: Retrospective comparison of CO-CS and AO-CS with CO idiopathic GHD (IGHD) and AO non-functioning pituitary adenoma patients (NFPA) and with the general population (standardized incidence ratio, SIR)...
December 7, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29227295/an-unusual-presentation-of-pituitary-gland-apoplexy-with-noninfectious-meningitis
#8
Margaret LaPorte, Jenna Pollock, Michael Ward, James Fulcher
Pituitary adenomas make up 10% of intracranial tumors, but because of their location, they may go undetected for long periods. In this article, we report the case of a 68-year-old white man found deceased in his residence, who died of acute pituitary tumor apoplexy. He was known to have severe symptoms including acute headache, vision loss, and altered behavior. When found, his home was in extreme disarray, mimicking a possible assault. At autopsy, the decedent had multiple superficial abrasions about the upper and lower extremities, as well as a 2...
December 7, 2017: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/29222642/pituitary-adenomas-stem-cells-and-cancer-stem-cells-what-s-new
#9
REVIEW
M Caffarini, M Orciani, L Trementino, R Di Primio, G Arnaldi
PURPOSE: To clarify the existence of pituitary stem cells (SCs) both in the embryonic and the postnatal gland and the role for SCs in pituitary adenomas. METHODS: This work, which does not address the pathogenesis of pituitary adenomas, reviews the latest research findings and discoveries on SCs in pituitary and cancer SCs (CSCs) in pituitary adenomas and discusses the involvement of the EMT. RESULTS: Several groups using different approaches and techniques have demonstrated the existence of SCs and CSCs and as they are major players in pituitary adenoma onset...
December 8, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29219752/negative-surgical-exploration-in-patients-with-cushing-s-disease-benefit-of-two-thirds-gland-resection-on-remission-rate-and-a-review-of-the-literature
#10
Steven B Carr, Bette K Kleinschmidt-DeMasters, Janice M Kerr, Katja Kiseljak-Vassiliades, Margaret E Wierman, Kevin O Lillehei
OBJECTIVE The authors report their single-institution experience with the pathological findings, rates of remission, and complications in patients with presumed Cushing's disease (CD) who underwent a two-thirds pituitary gland resection when no adenoma was identified at the time of transsphenoidal surgery (TSS). The authors also review the literature on patients with CD, negative surgical exploration, and histological findings. METHODS This study is a retrospective analysis of cases found in neurosurgery and pathology department databases between 1989 and 2011...
December 8, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29218429/protein-expression-of-pttg1-as-a-diagnostic-biomarker-in-adrenocortical-carcinoma
#11
Minerva Angélica Romero Arenas, Timothy G Whitsett, Anna Aronova, Samuel A Henderson, Janine LoBello, Mouhammed Amir Habra, Elizabeth G Grubbs, Jeffrey E Lee, Kanishka Sircar, Rasa Zarnegar, Theresa Scognamiglio, Thomas J Fahey, Nancy D Perrier, Michael J Demeure
BACKGROUND: Adrenocortical carcinoma (ACC) has a poor prognosis and there is an unmet clinical need for biomarkers to improve both diagnostic and prognostic assessment. Pituitary-tumor transforming gene (PTTG1) has been shown to modulate cancer invasiveness and response to therapy. The potential role of PTTG1 protein levels in ACC has not been previously addressed. We assessed whether increased nuclear protein expression of PTTG1 distinguished ACCs from adrenocortical adenomas (ACAs)...
December 7, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29214049/latent-autoimmune-diabetes-of-adulthood-case-report
#12
Cristen P Page, Brian Fitzgerald, Emily M Hawes
Background: Primary care clinicians will see a higher incidence of type 2 diabetes in adult patients, and the diagnosis and management of an initial presentation of type 1 diabetes can pose challenges to clinicians who see it less frequently. Symptoms of hyperglycemia and risk of ketoacidosis may be missed. Further, endocrine autoimmune disease can run together in patients and families. Case presentation: A 49-year-old Caucasian female with history of pituitary adenoma and Graves' disease with history of thyroid ablation presented in the outpatient setting due to hand tingling of her right middle finger that was worse in the mornings and improved throughout the day...
2017: Clinical Diabetes and Endocrinology
https://www.readbyqxmd.com/read/29209366/comment-on-identification-of-differentially-expressed-genes-in-pituitary-adenomas-by-integrating-analysis-of-microarray-data
#13
COMMENT
Mateusz Bujko
No abstract text is available yet for this article.
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29208862/impact-of-magnetic-resonance-imaging-in-the-diagnosis-of-pituitary-adenoma
#14
M I Hossain, M G Hafiz, S Choudhury, G N Islam, A Islam, M M Ahsan, M M Hossain
Pituitary adenoma is the third most common primary intracranial neoplasm involving the adult population with clinical features due to excess or deficient hormone secretion or due to its mass effect. Debate about the diagnostic accuracy, sensitivity and specificity of MRI imaging in detecting pituitary adenoma has been continuing. The study was aimed to evaluate the accuracy, sensitivity and specificity of MR imaging in detecting pituitary adenoma. This cross sectional study was conducted in the Department of Radiology and imaging, Bangabandhu Sheikh Mujib medical University (BSMMU) from July 2013 to August 2015...
October 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29205401/how-many-proteins-can-be-identified-in-a-2-de-gel-spot-within-an-analysis-of-a-complex-human-cancer-tissue-proteome
#15
Xianquan Zhan, Haiyan Yang, Fang Peng, Jianglin Li, Yun Mu, Ying Long, Tingting Cheng, Yuda Huang, Zhao Li, Miaolong Lu, Na Li, Maoyu Li, Jianping Liu, Peter R Jungblut
Two-dimensional gel electrophoresis (2-DE) in proteomics is traditionally assumed to contain only one or two proteins in each 2-DE spot. However, 2-DE resolution is being complemented by the rapid development of high sensitivity mass spectrometers. Here we compared MALDI-MS, LC-Q-TOF MS and LC-Orbitrap Velos MS for the identification of proteins within one spot. With LC-Orbitrap Velos MS each Coomassie Blue-stained 2-DE spot contained an average of at least 42 and 63 proteins/spot in an analysis of a human glioblastoma proteome and a human pituitary adenoma proteome, respectively, if a single gel spot was analyzed...
December 4, 2017: Electrophoresis
https://www.readbyqxmd.com/read/29204279/sellar-plasmacytoma-presenting-with-symptoms-of-anterior-pituitary-dysfunction
#16
Ana G Ferreira, Tiago N Silva, Henrique V Luiz, Filipa D Campos, Maria C Cordeiro, Jorge R Portugal
Sellar plasmacytomas are rare and the differential diagnosis with non-functioning pituitary adenomas might be difficult because of clinical and radiological resemblance. They usually present with neurological signs and intact anterior pituitary function. Some may already have or eventually progress to multiple myeloma. We describe a case associated with extensive anterior pituitary involvement, which is a rare form of presentation. A 68-year-old man was referred to our Endocrinology outpatient clinic due to gynecomastia, reduced libido and sexual impotence...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29204019/histologically-confirmed-intracranial-tumors-managed-at-enugu-nigeria
#17
Chika Anele Ndubuisi, Samuel C Ohaegbulam, Linda U Iroegbu, Mike Ezeali Ekuma, Wilfred C Mezue, Uwadiegwu Alphonsus Erechukwu
Background: There is controversy about the global distribution of intracranial tumors (ICTs). The previous reports from Africa suggested low frequency and different pattern of distribution of brain tumors from what obtains in other continents. The limitations at that time, including paucity of diagnostic facilities and personnel, have improved. Objective: The objective of this study is to analyze the current trend and distribution of histology confirmed brain tumors managed in Enugu, in a decade...
October 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/29200677/evaluation-of-intraoperative-cytological-smears-for-diagnosis-of-brain-tumors-with-special-reference-to-immunohistochemistry
#18
Saurav Sarkar, Moumita Sengupta, Chhanda Datta, Uttara Chatterjee, Samarendra Nath Ghosh
Context: Brain tumors are heterogeneous group of benign and malignant tumors of glial, meningeal, neuronal, embryonal, and lymphoid origin. Rapid intraoperative diagnosis of the nature of the tumor helps the surgeon to plan the extent of surgery and modify it accordingly. Aims: (1) To establish the validity and reliability of squash cytology in the intraoperative diagnosis of brain tumors. (2) To correlate with histopathological report and immunohistochemistry (IHC) profile...
July 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/29200117/common-histologically-benign-tumors-of-the-brain
#19
Roy E Strowd, Jaishri O Blakeley
PURPOSE OF REVIEW: As a group, benign tumors account for the majority of primary neoplasms affecting the central nervous system (CNS). This article reviews the epidemiology, clinical presentation, neuroimaging features, and management of the most common of these tumors: meningiomas, schwannomas, and pituitary adenomas. RECENT FINDINGS: Awareness of the most common nonmalignant tumors of the CNS and their management guidelines is important as many of these tumors are managed conservatively, with neurologists playing a primary role in both surveillance and symptom management...
December 2017: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/29195552/geometric-and-dosimetric-quality-assurance-using-logfiles-and-a-3d-helical-diode-detector-for-dynamic-wavearc
#20
Hideaki Hirashima, Mitsuhiro Nakamura, Yuki Miyabe, Nobutaka Mukumoto, Megumi Uto, Kiyonao Nakamura, Takashi Mizowaki, Masahiro Hiraoka
PURPOSE: To conduct patient-specific geometric and dosimetric quality assurance (QA) for the Dynamic WaveArc (DWA) using logfiles and ArcCHECK (Sun Nuclear Inc., Melbourne, FL, USA). METHODS: Twenty DWA plans, 10 for pituitary adenoma and 10 for prostate cancer, were created using RayStation version 4.7 (RaySearch Laboratories, Stockholm, Sweden). Root mean square errors (RMSEs) between the actual and planned values in the logfiles were evaluated. Next, the dose distributions were reconstructed based on the logfiles...
November 2017: Physica Medica: PM
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