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Adenomas pituitary

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https://www.readbyqxmd.com/read/29667493/non-adenomatous-pituitary-tumours-mimicking-functioning-pituitary-adenomas
#1
Zize Feng, Zhigang Mao, Zongming Wang, Bing Liao, Yonghong Zhu, Haijun Wang
OBJECTIVE: Pituicytomas and granular cell tumours (GCTs) of the neurohypophysis are considered non-adenomatous neoplasms in the sellar region. The association between hormone hypersecretion and the tumours is seldom discussed and unclear. Therefore, we attempt to investigate this association based on our experience and a review of the literature. METHODS: We report three patients who presented with Cushing's syndrome- or acromegaly-like symptoms at our institution...
April 18, 2018: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29665752/histopathologic-findings-in-canine-pituitary-glands
#2
Margaret A Miller, David S Bruyette, J Catharine Scott-Moncrieff, Tina Jo Owen, José A Ramos-Vara, Hsin-Yi Weng, Andrea L Vanderpool, Annie V Chen, Linda G Martin, Deidre M DuSold, Sina Jahan
To optimize the histologic evaluation of hypophysectomy specimens, sections of 207 canine pituitary glands (196 postmortem, 11 hypophysectomy specimens) were reviewed. Adenohypophyseal proliferation was the most common (n = 79) lesion. Proliferative lesions were sparsely to densely granulated; the granules were usually basophilic to chromophobic and periodic acid-Schiff-positive. Adenohypophyseal proliferation was classified as hyperplasia (n = 40) if ≤2 mm diameter with intact reticulin network, as microadenoma (n = 22) for 1-5 mm homogeneous nodules with lost reticulin network, or as macroadenoma (n = 17) for larger tumors...
January 1, 2018: Veterinary Pathology
https://www.readbyqxmd.com/read/29664314/iran-pituitary-tumor-registry-description-of-the-program-and-initial-results
#3
Mohammad Ebrahim Khamseh, Mohammad Reza Mohajeri Tehrani, Zohreh Mousavi, Mojtaba Malek, Mehrnaz Imani, Nasim Hoshangian Tehrani, Mohammad Ghorbani, Hamideh Akbari, Farzaneh Sarvghadi, Atieh Amouzegar, Fatemeh Esfahanian, Nahid Hashemi Madani, Zahra Emami
BACKGROUND: This study was designed to present initial results on clinical presentation, therapeutic modalities, and outcome information of patients with pituitary tumors registered in Iran Pituitary Tumor Registry (IPTR). METHODS: We collected data from a web-based electronic medical records of patients with various pituitary tumors referred to four tertiary care centers in the country. Retrospective analysis was performed on demographic, clinical, and therapeutic information of 298 patients including 51 clinically nonfunctioning adenoma (CNFA), 85 acromegaly, 135 prolactinoma, and 27 Cushing's disease (CD)...
December 31, 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29660734/interpretation-of-serum-gonadotropin-levels-in-hyperprolactinemia
#4
Ali Abbara, Sophie A Clarke, Alexander Nesbitt, Sabreen Ali, Alexander N Comninos, Emma Hatfield, Niamh Martin, Amir Sam, Karim Meeran, Waljit S Dhillo
<br>Background/Aims: Hyperprolactinemia is a common cause of amenorrhea due to hypogonadotropic hypogonadism. Prolactin is hypothesized to impede the reproductive axis through an inhibitory action at the hypothalamus. However, limited data exists to aid the interpretation of serum gonadotropins in the context of hyperprolactinemia. METHODS: Serum gonadotropin values were reviewed in 243 patients with elevated serum monomeric prolactin due to discrete etiologies at a tertiary reproductive endocrine centre between 2012 and 2015...
April 16, 2018: Neuroendocrinology
https://www.readbyqxmd.com/read/29659365/-association-between-diabetic-ketoacidosis-and-acromegaly
#5
Paloma Ocampo, Juan Manuel Duarte, Ricardo Barcia, Cecilia Arévalo
Diabetes mellitus occurs in nearly 10% of patients with acromegaly and is secondary to insulin resistance caused by high levels of growth hormone. Diabetes ketoacidosis has been described as a rare complication of acromegaly, resulting from a relative insulin deficiency caused by growth hormone excess. We described the case of a 38 year-old man who presented to the emergency room with a 6-week history of polydipsia, polyuria, polyphagia and weight loss. He also had nausea, vomiting and abdominal pain from two days before admission...
2018: Medicina
https://www.readbyqxmd.com/read/29658936/two-dimensional-gel-electrophoresis-coupled-with-mass-spectrometry-methods-for-an-analysis-of-human-pituitary-adenoma-tissue-proteome
#6
Xianquan Zhan, Yuda Huang, Ying Long
Human pituitary adenoma (PA) is a common tumor that occurs in the human pituitary gland in the hypothalamus-pituitary-targeted organ axis systems, and may be classified as either clinically functional or nonfunctional PA (FPA and NFPA). NFPA is difficult for early stage diagnosis and therapy due to barely elevating hormones in the blood compared to FPA. Our long-term goal is to use proteomics methods to discover reliable biomarkers for clarification of PA molecular mechanisms and recognition of effective diagnostic, prognostic markers and therapeutic targets...
April 2, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29652231/endoscopic-endonasal-transoculomotor-triangle-approach-for-adenomas-invading-the-parapeduncular-space-surgical-anatomy-technical-nuances-and-case-series
#7
Cristian Ferrareze Nunes, Stefan Lieber, Huy Q Truong, Georgios Zenonos, Eric W Wang, Carl H Snyderman, Paul A Gardner, Juan C Fernandez-Miranda
OBJECTIVE Pituitary adenomas may extend into the parapeduncular space by invading through the roof of the cavernous sinus. Currently, a transcranial approach is the preferred choice, with or without the combination of an endonasal approach. In this paper the authors present a novel surgical approach that takes advantage of the natural corridor provided by the tumor to further open the oculomotor triangle and resect tumor extension into the parapeduncular space. METHODS Six injected specimens were used to demonstrate in detail the surgical anatomy related to the approach...
April 13, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29650226/are-cushing-s-disease-patients-curable
#8
Xavier Bertagna
Treatment of Cushing's disease remains a challenge. Whereas pituitary surgery can "cure" the patient and restore a completely normal pituitary adrenal axis, there are immediate failures and late recurrences which ultimately require alternate therapeutic approaches. These are numerous, but so are their drawbacks, and all appear to be "default options". For the future, pituitary adenoma has to remain the "reasonable obsession" of efficient and optimistic therapists….
April 9, 2018: Annales D'endocrinologie
https://www.readbyqxmd.com/read/29625306/low-grade-glioma-of-the-neurohypophysis-clinical-characteristics-and-surgical-outcomes
#9
Yuichi Nagata, Naoko Inoshita, Noriaki Fukuhara, Mitsuo Yamaguchi-Okada, Hiroshi Nishioka, Shozo Yamada
BACKGROUND: Low-grade glioma (LGG) of the neurohypophysis is an extremely rare tumor arising from the pituicytes of the posterior pituitary or the infundibulum. The preoperative imaging findings of these tumors mimic those of pituitary adenomas, and radical resection is often challenging in affected patients due to the hypervascularity of the tumor. Here, we describe the clinical and radiological features of this clinical entity. METHODS: We identified 8 patients with LGG of the neurohypophysis...
April 3, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29624099/use-of-electronic-health-records-to-characterize-a-rare-disease-in-the-usa-treatment-comorbidities-and-follow-up-trends-among-patients-with-a-confirmed-diagnosis-of-acromegaly
#10
Julie M Silverstein, Erin D Roe, Kashif M Munir, Janet L Fox, Birol Emir, Maria Kouznetsova, Lois E Lamerato, Donna King
Purpose Understanding of acromegaly disease management is hampered in the US by lack of a national registry. We describe medical management in a population with confirmed acromegaly. Methods Inpatient and outpatient Electronic Health Records (EHR) were used to create a database of de-identified patients assigned the Acromegaly and Gigantism ICD-9 code and/or an appropriate pituitary procedure code at one of four regional hospital systems over a 6-11 year period. Information regarding demographics, medical history, labs, procedures and medications was collected and supplemented with a chart review to validate the diagnosis of acromegaly...
April 6, 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29623588/recurrent-non-functioning-pituitary-adenomas-a-review-on-the-new-pathological-classification-management-guidelines-and-treatment-options
#11
REVIEW
P D Delgado-López, J Pi-Barrio, M T Dueñas-Polo, M Pascual-Llorente, M C Gordón-Bolaños
At least 50% of surgically resected non-functioning pituitary adenomas (NFPA) recur. Either early or late adjuvant radiotherapy is highly efficacious in controlling recurrent NFPA but associates potentially burdensome complications like hypopituitarism, vascular complications or secondary neoplasm. Reoperation is indicated in bulky tumor rests compressing the optic pathway. To date, no standardized medical therapy is available for recurrent NFPA although cabergoline and temozolomide show promising results. Guidelines on the management of recurrent NFPAs are now available...
April 5, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29623208/a-rare-challenging-case-of-co-existent-craniopharyngioma-acromegaly-and-squamous-cell-lung-cancer
#12
Athanasios Fountas, Shu Teng Chai, John Ayuk, Neil Gittoes, Swarupsinh Chavda, Niki Karavitaki
Co-existence of craniopharyngioma and acromegaly has been very rarely reported. A 65-year-old man presented with visual deterioration, fatigue and frontal headaches. Magnetic resonance imaging revealed a suprasellar heterogeneous, mainly cystic, 1.9 × 2 × 1.9 cm mass compressing the optic chiasm and expanding to the third ventricle; the findings were consistent with a craniopharyngioma. Pituitary hormone profile showed hypogonadotropic hypogonadism, mildly elevated prolactin, increased insulin-like growth factor 1 (IGF-1) and normal thyroid function and cortisol reserve...
2018: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29622689/protein-stabilization-by-rsume-accounts-for-pttg-pituitary-tumor-abundance-and-oncogenicity
#13
Mariana Fuertes, Melanie Sapochnik, Lucas Tedesco, Sergio Senin, Alejandra Attorresi, Pablo Ajler, Guillermo Carrizo, Andrés Cervio, Gustavo Sevlever, Juan José Bonfiglio, Günter K Stalla, Eduardo Arzt
Increased levels of the proto-oncogene pituitary tumor transforming gene 1 (PTTG) have been repeatedly reported in several human solid tumors, especially in endocrine-related tumors such as pituitary adenomas. Securin PTTG has a critical role in pituitary tumorigenesis. However, the cause of upregulation has not been found yet, despite analyses made at the gene, promoter and mRNA level that show that no mutations, epigenetic modifications or other mechanisms that deregulate its expression may explain its overexpression and action as an oncogene...
April 5, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29622503/multidisciplinary-management-of-an-intra-sellar-cavernous-hemangioma-case-report-and-review-of-the-literature
#14
S Chibbaro, H Cebula, M Ganau, A Gubian, J Todeschi, B Lhermitte, F Proust, G Noel
Extra-axial cavernous hemangiomas (ECH) are rare vascular lesions with a tendency to grow within the medial structures of the middle cranial fossa. This pathological entity lacks specific symptoms, and falls into the category of differential diagnosis of space occupying lesions in the cavernous sinus (CS) with or without sellar involvement, including those of tumoral, vascular and inflammatory nature. Of note, ECH can also be indolent, and is at times discovered incidentally during autopsy investigations. On radiological studies, ECH with sellar extension are frequently mistaken at first for pituitary adenomas...
April 2, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29620167/decreased-expression-of-sfrp2-promotes-development-of-the-pituitary-corticotroph-adenoma-by-upregulating-wnt-signaling
#15
Jie Ren, Fangfang Jian, Hong Jiang, Yuhao Sun, Sijian Pan, Changwei Gu, Xiao Chen, Weiqing Wang, Guang Ning, Liuguan Bian, Qingfang Sun
Cushing's disease is primarily caused by pituitary adrenocorticotropin‑secreting adenoma. However, its pathogenesis has remained obscure. In the present study, whole transcriptome analysis was performed by RNA sequencing (RNA‑Seq) and expression of secreted frizzled‑related protein 2 (SFRP2) was decreased in corticotroph tumors compared with normal pituitary glands. Furthermore, the RNA‑Seq results were validated and the expression of SFRP2 in tumor tissues was analyzed by comparing another cohort of 23 patients with Cushing's disease and 3 normal human pituitary samples using reverse transcription‑quantitative polymerase chain reaction, western blot and immunohistochemistry staining...
April 3, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29618106/contribution-of-intrasellar-pressure-elevation-to-headache-manifestation-in-pituitary-adenoma-evaluated-with-intraoperative-pressure-measurement
#16
Yasuhiko Hayashi, Yasuo Sasagawa, Masahiro Oishi, Daisuke Kita, Koichi Misaki, Issei Fukui, Osamu Tachibana, Mitsutoshi Nakada
BACKGROUND: Headache frequently occurs in patients with pituitary adenoma and is reported in large as well as small adenomas. However, the exact mechanism of headache derived from pituitary adenoma remains unknown. OBJECTIVE: To evaluate the contribution of intrasellar pressure (ISP) to headache manifestation by using intraoperative ISP measurement. METHODS: The records of 108 patients who had first-time transsphenoidal surgery for pituitary adenoma were reviewed retrospectively...
March 29, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29615979/landscape-of-molecular-events-in-pituitary-apoplexy
#17
REVIEW
Prakamya Gupta, Pinaki Dutta
Apoplectic pituitary adenomas cause significant morbidity and even mortality. The pituitary apoplexy denotes a pituitary adenoma presenting with hemorrhage and/or infarction, implementation in remedial effects of various of drugs in pituitary apoplexy is a promising pharmacogenomic field in the near future adenoma treatment. Indisputably, this is an important horizon for complicated pituitary adenomas. In a pituitary adenoma, the interplay between genetic, cytokine, and growth factors promotes the pathogenic transformation into an apoplectic formation...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29604507/confocal-scanning-microscopy-provides-rapid-detailed-intraoperative-histological-assessment-of-brain-neoplasms-experience-with-106-cases
#18
Nikolay L Martirosyan, Joseph Georges, Jennifer M Eschbacher, Evgenii Belykh, Alessandro Carotenuto, Robert F Spetzler, Peter Nakaji, Mark C Preul
OBJECTIVES: Frozen section histological analysis is currently the mainstay for intraprocedural tissue diagnosis during the resection of intracranial neoplasms and for evaluating tumor margins. However, frozen sections are time-consuming and often do not reveal the histological features needed for final diagnosis when compared with permanent sections. Confocal scanning microscopy (CSM) with certain stains may be a valuable technology that can add rapid and detailed histological assessment advantage for the neurosurgical operating room...
March 21, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29604339/expression-of-the-long-non-coding-rna-h19-and-malat-1-in-growth-hormone-secreting-pituitary-adenomas-and-its-relationship-to-tumor-behavior
#19
Tianyu Lu, Chen Yu, Hongbin Ni, Weibang Liang, Huiying Yan, Wei Jin
Aggressive growth hormone-secreting pituitary adenomas (GHPAs) represent an important clinical problem in patients with acromegaly. Surgical therapy, although often the mainstay of treatment for GHPAs, is less effective in aggressive GHPAs due to their invasive and destructive growth patterns, and their proclivity for infrasellar invasion. LncRNAs are important players in cancer development and emerging in various fundamental biological processes. In the present study, qRT-PCR was performed to examine the expression of lncRNA H19 and MALAT-1 in invasive and non-invasive GHPAs...
March 28, 2018: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29600293/-usp8-mutations-in-pituitary-cushing-adenomas-targeted-analysis-by-next-generation-sequencing
#20
Cora Ballmann, Anne Thiel, Hannah E Korah, Anna-Carinna Reis, Wolfgang Saeger, Stefanie Stepanow, Karl Köhrer, Guido Reifenberger, Christiane B Knobbe-Thomsen, Ulrich J Knappe, Ute I Scholl
Gain-of-function somatic mutations in the ubiquitin specific protease 8 ( USP8 ) gene have recently been reported as a cause of pituitary adenomas in Cushing disease. Molecular diagnostic testing of tumor tissue may aid in the diagnosis of specimens obtained through therapeutic transsphenoidal surgery; however, for small tumors, availability of fresh tissue is limited, and contamination with normal tissue is frequent. We performed molecular testing of DNA isolated from single formalin-fixed and paraffin-embedded (FFPE) tissue sections of 42 pituitary adenomas from patients with Cushing disease (27 female patients and 15 male patients; mean age at surgery, 42...
March 1, 2018: Journal of the Endocrine Society
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