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Adenomas pituitary

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https://www.readbyqxmd.com/read/29027863/potential-utility-of-flair-in-mri-negative-cushing-s-disease
#1
Grégoire P Chatain, Nicholas Patronas, James G Smirniotopoulos, Martin Piazza, Sarah Benzo, Abhik Ray-Chaudhury, Susmeeta Sharma, Maya Lodish, Lynnette Nieman, Constantine A Stratakis, Prashant Chittiboina
OBJECTIVE Accurate presurgical localization of microadenomas in Cushing's disease (CD) leads to improved remission rates and decreased adverse events. Volumetric gradient recalled echo (3D-GRE) MRI detects pituitary microadenomas in CD in up to 50%-80% cases as a focus of hypointensity due to delayed contrast wash-in. The authors have previously reported that postcontrast FLAIR imaging may be useful in detecting otherwise MRI-negative pituitary microadenomas as foci of hyperintensity. This reflects theoretically complementary imaging of microadenomas due to delayed contrast washout...
October 13, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29027854/long-term-outcomes-of-tissue-based-acth-antibody-assay-guided-transsphenoidal-resection-of-pituitary-adenomas-in-cushing-disease
#2
J Mark Erfe, Avital Perry, John McClaskey, Silvio E Inzucchi, Whitney Sheen James, Tore Eid, Richard A Bronen, Amit Mahajan, Anita Huttner, Florecita Santos, Dennis Spencer
OBJECTIVE Cushing disease is caused by a pituitary micro- or macroadenoma that hypersecretes adrenocorticotropic hormone (ACTH), resulting in hypercortisolemia. For decades, transsphenoidal resection (TSR) has been an efficacious treatment but with certain limitations, namely precise tumor localization and complete excision. The authors evaluated the novel use of a double-antibody sandwich assay for the real-time quantitation of ACTH in resected pituitary specimens with the goals of augmenting pathological diagnosis and ultimately improving long-term patient outcome...
October 13, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29026467/chromogranin-a-as-a-biochemical-marker-for-neuroendocrine-tumors-a-single-center-experience-at-royal-hospital-oman
#3
Elham S Al-Risi, Fatma S Al-Essry, Waad-Allah S Mula-Abed
OBJECTIVES: To evaluate the significance of serum chromogranin A (CgA) status in patients with and without different neuroendocrine tumors (NETs) by conducting a retrospective assessment of the diagnostic utility and limitations of CgA as a biomarker for NETs in a tertiary care hospital in Oman. METHODS: We conducted a retrospective analysis of CgA requests referred to the Clinical Biochemistry Laboratory, Royal Hospital, Oman over a 24-month period (April 2012 to March 2014)...
September 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/29026095/alterations-of-regional-homogeneity-and-functional-connectivity-in-pituitary-adenoma-patients-with-visual-impairment
#4
Guidong Song, Jicheng Qiu, Chuzhong Li, Jiye Li, Songbai Gui, Haibo Zhu, Yazhuo Zhang
Evidences have showed that the deprivation of vision can considerably alter the resting-state activity both within and beyond the visual cortices. However, the functional changes of the brain cortices related to partially vision-deprivation are still largely unknown. Using resting-state functional MR imaging, we quantitatively evaluated the regional homogeneity(ReHo) and functional connectivity(FC) changes between 25 pituitary adenoma patients with visual impairment and 25 healthy controls(HCs). Compared with HCs, PAs exhibited significant increased ReHo in the left superior occipital gyrus, bilateral middle occipital gyrus and reduced ReHo in the left inferior frontal gyrus and right middle temporal gyrus...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29025207/a-rare-case-of-multiple-pituitary-adenomas-in-an-adolescent-cushing-disease-presenting-as-a-vertebral-compression-fracture
#5
Ji-Yeon Song, Sue-Jean Mun, Soon-Ki Sung, Jae-Yeon Hwang, Seung-Kug Baik, Jee Yeon Kim, Chong-Kun Cheon, Su-Young Kim, Yoo-Mi Kim
Cushing disease in children and adolescents, especially with multiple pituitary adenomas (MPAs), is very rare. We report 17-year-old boy with MPAs. He presented with a vertebral compression fracture, weight gain, short stature, headache, and hypertension. On magnetic resonance imaging (MRI), only a left pituitary microadenoma was found. After surgery, transient clinical improvement was observed but headache and hypertension were observed again after 3 months later. Follow-up MRI showed a newly developed right pituitary microadenoma 6 months after the surgery...
September 2017: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29022767/%C3%AE-glucosidase-inhibitory-and-cytotoxic-botryorhodines-from-mangrove-endophytic-fungus-trichoderma-sp-307
#6
Liuhong Zhang, Shah Iram Niaz, Zhen Wang, Yonghong Zhu, Yongcheng Lin, Jing Li, Lan Liu
One new depsidone, botryorhodine H (1), together with three known analogues, botryorhodines C, D and G (2-4), were obtained from the mangrove endophytic fungus Trichoderma sp. 307 by co-culturing with Acinetobacter johnsonii B2. Structures were determined by 1D and 2D NMR analyses and high-resolution mass spectrum. Compounds 1-3 showed α-glucosidase inhibitory activity with IC50 ranging from 8.1 to 11.2 μM, and compound 1 exhibited potent cytotoxicity against rat prolactinoma MMQ and rat pituitary adenoma GH3 cell lines (IC50 = 3...
October 12, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29022641/-familial-isolated-pituitary-adenomas-fipa-case-report-of-four-families-and-review-of-literature
#7
Joanna Elżbieta Malicka, Joanna Świrska, Maria Kurowska, Marta Dudzińska, Jerzy S Tarach
BackgroundThe majority of pituitary adenomas are sporadic, but about 5% of them occur in a familial setting, predominantly in multiple endocrine neoplasia type 1 and Carney complex. Familial isolated pituitary adenomas (FIPA), unrelated to the syndromes mentioned above, were also described. The clinical course of FIPA differs significantly from sporadic cases, and is characterized by a larger tumor size, more aggressive course and younger patients' age at the moment of recognition. ObjectivesThe aim of this retrospective study is to present 4 families in which two closely related people were diagnosed with pituitary adenomas...
October 12, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/29022276/diagnosis-and-treatment-of-tsh-secreting-adenomas-review-of-a-longtime-experience-in-a-reference-center
#8
D M Nazato, J Abucham
PURPOSE: TSH-secreting pituitary adenomas are among the less prevalent pituitary tumors, corresponding to 0.9-1.5% of all pituitary adenomas in surgical series. METHODS: A series of 11 patients with TSH-secreting and cosecreting adenomas diagnosed and treated in the last 25 years in a single center is described. RESULTS: The mean age at diagnosis was 37 years (range 18-80 years; median 23 years); the ratio of male-to-female patients was similar (6M:5F)...
October 11, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29019897/endocan-expression-is-correlated-with-poor-progression-free-survival-in-patients-with-pancreatic-neuroendocrine-tumors
#9
Liang-Yu Lin, Yi-Chen Yeh, Chia-Huei Chu, Justin G S Won, Yi-Ming Shyr, Yee Chao, Chung-Pin Li, Shin-E Wang, Ming-Huang Chen
Endocan expression has been reported to be associated with aggressive tumor progression and poor outcomes in various cancers, such as breast cancer, renal cell cancer, lung cancer, gastric cancer, and pituitary adenomas. However, the prognostic significance of endocan in neuroendocrine tumors remains unknown. Thus, the aim of this study was to determine the correlation between endocan expression in pancreatic neuroendocrine tumor (PNET) tissues and progression-free survival. This study included 73 patients with confirmed PNETs who were treated in a single tertiary center in north Taiwan between 1992 and 2015...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29017983/endoscopic-transsphenoidal-surgery-outcomes-in-331-nonfunctioning-pituitary-adenoma-cases-following-a-single-surgeon-learning-curve
#10
Jung Hee Kim, Jung Hyun Lee, Ji Hyun Lee, A Ram Hong, Yoon Ji Kim, Yong Hwy Kim
OBJECTIVE: The outcomes of recent endoscopic surgery of nonfunctioning pituitary adenomas (NFPAs) were controversial when compared to traditional microscopic surgery. We aimed to assess the outcomes of endoscopic transsphenoidal surgeries performed by one surgeon with 7 years of experience and elucidate the predictive factors for surgical outcomes for NFPAs. METHODS: We included 331 patients (155 men, 176 women) with clinical NFPAs who underwent transsphenoidal surgery due to visual symptoms by a single surgeon in Seoul National University Hospital from March 2010 to May 2016...
October 7, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29016590/endoscopic-endonasal-transsphenoidal-approach-to-pituitary-adenoma-a-multi-disciplinary-approach
#11
Deepak Regmi, Amit Thapa, Bidur Kc, Bikram Shakya
BACKGROUND: The excellent visualization and minimally invasive approach employed in endoscopic endonasal procedures has now revolutionized the pituitary surgery, replacing the transnasal microscopic technique worldwide. However, it involves major shift in hand-eye co-ordination from static 3 dimensional images of microscope to 2 dimensional endoscopic images hence demands training and inter-disciplinary approach. Here we present our experiences in learning and developing a safe endonasal transsphenoidal endoscopic approach to resect pituitary adenomas...
September 8, 2017: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/28994039/utility-of-pit-1-immunostaining-in-distinguishing-pituitary-adenomas-of-primitive-differentiation-from-null-cell-adenomas
#12
Julieann C Lee, Melike Pekmezci, Jonathan L Lavezo, Hannes Vogel, Laurence Katznelson, Merav Fraenkel, Griffith Harsh, Mohanpal Dulai, Arie Perry, Tarik Tihan
Pit-1 immunostaining is not routinely used in the characterization of pituitary adenomas, and its utility in distinguishing adenomas dedicated towards the lactotroph, somatotroph, and thyrotroph lineage from null cell adenomas warrants further evaluation. Pituitary adenomas that were negative for expression of a basic panel of hormonal markers (ACTH, prolactin, and growth hormone) were further evaluated for TSH, SF-1, and Pit-1 expression using a tissue microarray. Among the 147 identified pituitary adenomas that were negative for ACTH, prolactin, growth hormone, and TSH, expression of SF-1 was present in 68 cases (46%)...
October 9, 2017: Endocrine Pathology
https://www.readbyqxmd.com/read/28992711/-treatment-of-pituitary-adenomas
#13
Jana Ježková, Josef Marek, Manuela Vaněčková
Pituitary adenomas are the most common tumours of the sellar region. A combination of neurosurgery, radiation and pharmacological approaches are applied for the treatment of pituitary adenomas. In certain cases, patient observation is another option. Neurosurgery is the first-choice treatment for acromegaly, Cushing´s disease and TSH secreting adenomas. Leksell gamma knife irradiation is used in the treatment of tumour residues. Until the effect of the irradiation is evident, pharmacological treatment must be administered...
2017: Casopís Lékar̆ů C̆eských
https://www.readbyqxmd.com/read/28992707/-overgrowth-in-children-and-in-adults-novel-clinical-view-novel-genes-novel-phenotypes
#14
Jan Lebl, Lukáš Plachý, Květa Bláhová, Lenka Elblová, Filip Fencl, Stanislava Koloušková, Štěpánka Průhová
Novel genetic findings allow to more reliably elucidate the aetiology and pathogenesis of overgrowth syndromes in children and in adults. The relatively prevalent overgrowth syndromes in foetuses and neonates include Beckwith-Wiedemann (BWS) and Sotos syndromes; in addition, several rare conditions may occur e.g. Simpson-Golabi-Behmel and Weaver syndromes. These syndromes are not connected with overproduction of growth hormone. Their carriers are at risk of hypoglycaemia (in BWS), of congenital malformations and of childhood tumours...
2017: Casopís Lékar̆ů C̆eských
https://www.readbyqxmd.com/read/28990677/left-ventricular-twist-is-impaired-in-acromegaly-insights-from-the-three-dimensional-speckle-tracking-echocardiographic-magyar-path-study
#15
Árpád Kormányos, Péter Domsik, Anita Kalapos, Andrea Orosz, Csaba Lengyel, Zsuzsanna Valkusz, Attila Trencsányi, Tamás Forster, Attila Nemes
INTRODUCTION: Acromegaly is a rare, chronic, disfiguring, and debilitating disease caused, in 90% of cases, by a benign monoclonal growth hormone-secreting pituitary adenoma. The present study aimed to assess left ventricular (LV) rotational and twist mechanics in acromegalic patients and to compare their results to age- and gender-matched healthy controls. METHODS: The present study comprised 24 acromegalic patients, from which 4 were excluded due to insufficient image quality (mean age: 57...
October 9, 2017: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/28989047/delayed-complications-after-transsphenoidal-surgery-for-pituitary-adenomas
#16
REVIEW
Gmaan Alzhrani, Walavan Sivakumar, Min S Park, Phil Taussky, William T Couldwell
Perioperative complications after transsphenoidal surgery for pituitary adenomas have been well documented in the literature; however, some complications can occur in a delayed fashion postoperatively and reports are sparse about their occurrence, management, and outcome. Here, we describe delayed complications after transsphenoidal surgery and discuss the incidence, temporality from the surgery, and management of these complications based on the findings of studies that reported delayed postoperative epistaxis, delayed postoperative cavernous carotid pseudoaneurysm formation and rupture, vasospasm, delayed symptomatic hyponatremia (DSH), hypopituitarism, hydrocephalus, and sinonasal complications...
October 5, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28988650/learning-curve-of-endoscopic-pituitary-surgery-experience-of-a-neurosurgery-ent-collaboration
#17
Giorgio Lofrese, Vera Vigo, Mario Rigante, Domenico Luca Grieco, Maddalena Maresca, Carmelo Anile, Annunziato Mangiola, Pasquale De Bonis
For neurosurgeons, who are accustomed to the binocular microscope, there is a new learning curve that must be overcome for monocular endoscopic pituitary surgery. Different studies describe a learning curve between 15 and 200 procedures, after which both operative time and complications stabilize. In this retrospective study, we evaluate the endoscopic learning curve of our group, already trained in microsurgical transsphenoidal surgery, with the assistance of ear, nose, and throat (ENT) surgeons. From 2010 to 2015, a total of 95 patients with pituitary adenomas were treated with a purely endoscopic approach...
October 5, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28982703/somatic-usp8-mutations-are-frequent-events-in-corticotroph-tumor-progression-causing-nelson-s-tumor
#18
Luis G Perez-Rivas, Marily Theodoropoulou, Troy H Puar, Julia Fazel, Mareike R Stieg, Francesco Ferrau, Guillaume Assie, Monica R Gadelha, Timo Deutschbein, Maria C Fragoso, Benno Kusters, Wolfgang Saeger, Juergen Honegger, Michael Buchfelder, Marta Korbonits, Jerome Bertherat, Gunter K Stalla, Ad Hermus, Felix Beuschlein, Martin Reincke
Objective Somatic mutations in the ubiquitin-specific protease 8 (USP8) gene are frequent in corticotroph tumors causing Cushing's disease. Corticotroph tumor progression, the so-called Nelson's syndrome, is a potentially life-threatening complication of bilateral adrenalectomy in patients with refractory Cushing's disease that is caused by the development of an ACTH-secreting tumor of the pituitary gland. Whether USP8 alterations are also present in progressive Nelson's tumors has not been studied in detail so far...
October 5, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28980049/effects-of-endogenous-hypercortisolism-on-bone-mrna-and-microrna-expression-in-humans
#19
Z E Belaya, T A Grebennikova, G A Melnichenko, A G Nikitin, A G Solodovnikov, O I Brovkina, A U Grigoriev, L Y Rozhinskaya, I I Dedov
Hypercortisolism in humans suppresses osteoblastogenesis and osteoblast function through the upregulation of Wnt-signaling antagonists (sclerostin, Dkk1) and changes in microRNAs levels (miR-125b-5p, miR-218-5p, miR-34a-5p, miR-188-3p, miR-199a-5p) which are associated with mesenchymal stem-cell commitment to adipocytes or cartilage cells over the osteoblasts. INTRODUCTION: The purpose of this study was to evaluate the responses of bone to chronic glucocorticoid (GC) excess by measuring the levels of selected mRNA and microRNA (miR) in bone samples of patients with Cushing's disease (CD)...
October 4, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28979174/delayed-onset-of-isolated-unilateral-oculomotor-nerve-palsy-caused-by-post-traumatic-pituitary-apoplexy-a-case-report
#20
Tomoki Ishigaki, Yotaro Kitano, Hirofumi Nishikawa, Genshin Mouri, Shigetoshi Shimizu, Fumitaka Miya, Hidenori Suzuki
Post-traumatic pituitary apoplexy is uncommon, most of which present with a sudden onset of severe headache and visual impairments associated with a dumbbell-shaped pituitary tumor. We experienced an unusual case of post-traumatic pituitary apoplexy with atypical clinical features. A 66-year-old man presented with mild cerebral contusion and an incidentally diagnosed intrasellar tumor after a fall accident with no loss of consciousness. The patients denied any symptoms before the accident. After 4 days, the left oculomotor nerve palsy developed and deteriorated associated with no severe headache...
2017: Clinical Medicine Insights. Case Reports
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