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Adenomas pituitary

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https://www.readbyqxmd.com/read/29453734/post-operative-imaging-assessment-of-non-functioning-pituitary-adenomas
#1
REVIEW
Kunal S Patel, Sanjay Dhawan, Renzhi Wang, Bob S Carter, James Y Chen, Clark C Chen
BACKGROUND: Non-functioning pituitary adenomas (NFAs) are the most common pituitary tumors. There is significant variability in clinical practice in terms of post-operative imaging evaluation. The objective of this manuscript is to provide an exhaustive review of published articles pertaining to the post-operative imaging evaluation of NFAs. METHODS: The MEDLINE database was queried for studies investigating imaging for the post-operative evaluation of pituitary adenomas...
February 16, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29450857/hypokalemia-associated-with-pseudo-cushing-s-syndrome-and-magnesium-deficiency-induced-by-chronic-alcohol-abuse
#2
Masafumi Kurajoh, Keiko Ohsugi, Miki Kakutani-Hatayama, Takuhito Shoji, Hidenori Koyama
Hypokalemia and hypomagnesemia are frequently observed in patients with chronic alcoholism. However, the involvement of deranged cortisol regulation in patients with those conditions has not been reported. A 63-year-old Japanese male with chronic alcoholism was referred to the Department of Diabetes, Endocrinology and Metabolism for examination and treatment of hypokalemic periodic paralysis. Laboratory findings showed hypokalemia (2.3 mmol/l), as well as a high level of urinary excretion of potassium and hypomagnesemia (1...
February 15, 2018: CEN Case Reports
https://www.readbyqxmd.com/read/29450811/debulking-surgery-of-pituitary-adenoma-as-a-strategy-to-facilitate-definitive-stereotactic-radiosurgery
#3
Neil Forster, Ronald Warnick, Vinita Takiar, Luke Pater, John Breneman
In patients with pituitary adenomas (PA) who are unable to undergo complete surgical resection, radiation therapy (RT), specifically stereotactic radiosurgery (SRS), results in excellent local control. However, the utility of radiosurgery may be limited by the proximity of the lesion to the optic chiasm (OC). We evaluate the efficacy of debulking surgery in increasing the PA-OC separation to convert patients into SRS candidates. From 2007 to 2015, 31 patients with PA < 2 mm from the OC underwent debulking surgery followed by RT within 2 years of resection...
February 15, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29450378/ocular-posterior-pole-pathological-modifications-related-to-complicated-pregnancy-a-review
#4
REVIEW
Vanessa Andrada Păun, Zamfir-Radu Ionescu, Liliana Voinea, Monica Cîrstoiu, Alexandru Baroș, Ștefan Pricopie, Radu Ciuluvică
Ocular posterior pole modification are a pathological manifestation in complicated pregnancies, especially when pregnancy induced hypertension is present (PIH), as well as in preeclampsia (PE) or eclampsia. Nonetheless, as the pregnancy evolves, the possibility for an aggravated evolution with HELLP syndrome, disseminated intravascular coagulation, and idiopathic thrombocytopenic purpura may have an ocular manifestation that, mainly, implies a loss of visual field or acuity, that, left unattended, may constitute a permanent impairment...
April 2017: Romanian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29449735/alk-positive-adenocarcinoma-of-the-lung-expressing-neuroendocrine-markers-and-presenting-as-a-pituitary-adenoma
#5
M C Mengoli, F Bertolini, M Maur, F Barbieri, L Longo, P Gasparri, M Tiseo, G Rossi
We report an ALK-rearranged adenocarcinoma of the lung presenting as a pituitary metastasis, clinically simulating a pituitary adenoma. The patient, a 50 year-old, former-smoking woman was admitted with a Parinaud's syndrome characterized by progressive oculomotor impairment of visual verticality, bitemporal hemianopsia and nystagmus. Imaging studies showed a sellar tumor and the biopsy revealed a TTF-1 and napsin positive lung adenocarcinoma strongly expressing synaptophysin and CD56, also harboring ALK rearrangement...
December 2017: Pathologica
https://www.readbyqxmd.com/read/29448805/differentiating-skull-base-chordomas-and-invasive-pituitary-adenomas-with-conventional-mri
#6
Ankang Gao, Jie Bai, Jingliang Cheng, Xiao Cheng, Shujian Li, Zanxia Zhang, Yong Zhang
Background It is difficult to distinguish between invasive pituitary adenomas (IPAs) and skull base chordomas based on tumor location and clinical manifestations. Purpose To investigate the value of the apparent diffusion coefficient (ADC), T2-weighted (T2W) imaging, and dynamic contrast enhancement (DCE) in differentiating skull base chordomas and IPAs. Material and Methods Data for 21 patients with skull base chordomas and 27 patients with IPAs involving the paranasal sinus were retrospectively reviewed, and all diagnoses were pathologically confirmed...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29442480/cushing-s-disease-major-difficulties-in-diagnosis-and-management-during-pregnancy
#7
Francisca Caimari, Rosa Corcoy, Susan M Webb
Pregnancy in women with a diagnosis of Cushing' syndrome (CS) is an extremely rare event and its diagnosis and treatment are a real medical challenge. During pregnancy, the hypothalamus-pituitary-adrenal axis undergoes major changes leading to a significant increase in plasma cortisol levels throughout gestation. The difficulties in diagnosis are related to the resemblance of symptoms of CS and those of pregnancy, and to the complex interpretation of the screening tests. Moreover, the diagnostic work up in the postnatal period may be difficult in the first weeks postpartum...
February 13, 2018: Minerva Endocrinologica
https://www.readbyqxmd.com/read/29441449/non-functioning-pituitary-adenomas-not-all-the-same-and-certainly-not-boring
#8
EDITORIAL
Maria Fleseriu, Niki Karavitaki
No abstract text is available yet for this article.
February 13, 2018: Pituitary
https://www.readbyqxmd.com/read/29440241/-if-there-were-water-we-should-stop-and-drink-neurofibromatosis-presenting-with-diabetes-insipidus
#9
Rachel Barry, Antoinette O' Connor, Mohn Hazriq Awang, Orna O' Toole
A 58-year-old right-handed woman presented to our institution with a 1-month history of polydipsia and polyuria. She had a remote history of neurofibroma excision by dermatology and, on examination, was noted to meet the clinical diagnostic criteria for neurofibromatosis type 1. Laboratory investigations revealed hypernatraemia and elevated serum osmolality, accompanied by reduced urinary osmolality. A subsequent water deprivation test confirmed central diabetes insipidus, which responded to treatment with desmopressin...
February 11, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29440131/diagnostic-accuracy-and-comparison-of-bipss-in-response-to-lysine-vasopressin-and-hcrh
#10
Kush Dev Singh Jarial, Anil Bhansali, Vivek Gupta, Paramjeet Singh, Kanchan K Mukherjee, Akhilesh Sharma, Rakesh Vasishta, Suja P Sukumar, Naresh Sachdeva, Rama Walia
CONTEXT: Bilateral inferior petrosal sinus sampling (BIPSS) using hCRH is currently considered the 'gold standard' test for the differential diagnosis of ACTH-dependent Cushing's syndrome (CS). Vasopressin is more potent than CRH to stimulate ACTH secretion as shown in animal studies, however; no comparative data of its use is available during BIPSS. OBJECTIVE: To study the diagnostic accuracy and comparison of hCRH and lysine vasopressin (LVP) stimulation during BIPSS...
February 12, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29438167/insm1-is-a-sensitive-and-specific-marker-of-neuroendocrine-differentiation-in-head-and-neck-tumors
#11
Lisa M Rooper, Justin A Bishop, William H Westra
The head and neck is the site of a wide and sometimes bewildering array of neuroendocrine (NE) tumors. Although recognition of NE differentiation may be necessary for appropriate tumor classification and treatment, traditional NE markers such as synaptophysin, chromogranin, and CD56 are not always sufficiently sensitive or specific to make this distinction. Insulinoma-associated protein 1 (INSM1) is a novel transcription factor that has recently demonstrated excellent sensitivity and specificity for NE differentiation in various anatomic sites, but has not yet been extensively evaluated in tumors of the head and neck...
February 12, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29436283/universal-sellar-anatomical-reconstruction-using-the-sellar-floor-flap-after-endoscopic-pituitary-adenoma-surgery
#12
Zixiang Cong, Kaidong Liu, Guodao Wen, Liang Qiao, Handong Wang, Chiyuan Ma
Postoperative cerebrospinal fluid (CSF) leaks still occur in patients without intraoperative CSF leaks after endoscopic endonasal pituitary adenoma surgery. We propose a reconstructive technique, the sellar floor flap (SFF), for universal sellar anatomical reconstruction. A total of 113 patients without intraoperative CSF leaks after endoscopic endonasal pituitary adenoma surgery from July 2013 to June 2016 were reviewed: 43 underwent sellar reconstruction with the SFF (the SFF group) and 70 underwent sellar packing only (the nonreconstruction group)...
February 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29434861/bioinformatic-analysis-of-gene-expression-profiles-of-pituitary-gonadotroph-adenomas
#13
Ziming Hou, Jun Yang, Gang Wang, Changjiang Wang, Hongbing Zhang
The aim of the present study was to identify genes, microRNAs (miRNAs/miRs) or pathways associated with the development of pituitary gonadotroph adenomas. The array data of GSE23207, which included 16 samples of multiple endocrine neoplasia-associated rat pituitary homozygous mutations and 5 pituitary tissue samples from healthy rats, were downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) were analyzed prior to functional enrichment analysis and protein-protein interaction (PPI) network construction...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29433055/presurgical-treatment-with-somatostatin-analogues-in-growth-hormone-secreting-pituitary-adenomas-a-long-term-single-center-experience
#14
Liang Lv, Yu Hu, Peizhi Zhou, Shizhen Zhang, Senlin Yin, Nannan Zhang, Shu Jiang
OBJECTIVE: Acromegalic patients with macro- or giant adenomas often had poor prognosis after surgery. Somatostatin analogues (SSAs) show high effectiveness in both tumor shrinkage and serum GH reduction. But the role of SSAs in pre-surgical treatment and the management among macro- and giant adenomas remains controversial. PATIENTS AND METHODS: A total of 100 acromegalic patients with macro- or giant adenomas that underwent surgery in our institution between January 2010 and December 2016 were enrolled in the current retrospective study...
February 6, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29429349/-the-role-of-mirnas-in-the-pathogenesis-of-pituitary-adenomas
#15
Kinga Németh, Ottó Darvasi, Nikolette Szücs, Sándor Czirják, Henriett Butz
MicroRNAs (miRNAs) are short, single stranded RNA molecules which play regulatory roles through posttranscriptional regulation of their target genes. Based on our current knowledge, more than 30% of the human protein-coding genes are regulated by miRNAs, hence influencing basic cellular mechanisms including cell proliferation, differentiation and cell death. Differential miRNA expression pattern has been detected in many different types of tumors and, recently, several publications have referred to miRNAs as potential therapeutic targets...
February 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29428407/subclinical-haemorrhage-in-non-functional-adenomas
#16
H Cebula, E Fasciglione, M D N Santin, J Todeschi, F Severac, F Proust, J-L Dietemann, B Goichot
AIM: The prevalence and risk factors of subclinical haemorrhage on non-functional adenomas (NFA) remain controversial. The primary aim of our study was to assess the incidence of subclinical haemorrhage (SH) and the secondary objectives were to evaluate the risk factors of SH and the impact of SH on pituitary function at diagnosis. PATIENTS AND METHODS: This retrospective transversal analysis included 95 patients between January 2012 and December 2014. The patients included in this series were all adults (>18 years of age), who presented a non-functional adenoma confirmed by an endocrinological evaluation and on dedicated MRI pituitary imaging...
February 7, 2018: Neuro-Chirurgie
https://www.readbyqxmd.com/read/29426625/a-thyrotropin-secreting-pituitary-adenoma-treated-with-radiosurgery-long-term-outcomes
#17
Marta Araujo Castro, Bryan McIver, Pablo Valderrabano
No abstract text is available yet for this article.
February 6, 2018: Endocrinología, Diabetes y Nutrición
https://www.readbyqxmd.com/read/29425985/clinical-features-and-treatment-of-secondary-pituitary-abscess-following-transsphenoidal-surgery-a-retrospective-study-of-23-cases
#18
Ziquan Li, Chengxian Yang, Xinjie Bao, Yong Yao, Ming Feng, Kan Deng, Xiaohai Liu, Bing Xing, Renzhi Wang
OBJECTIVE: Pituitary abscess (PA) is a rare but serious intrasellar disorder with potentially high disability and mortality. Secondary PA following transsphenoidal surgery (TS) is extremely rare and only a few case reports were identified in the literature. This study explored the salient clinical manifestations and etiologies to determine appropriate treatment. METHODS: A retrospective review of 6,832 consecutive patients who had undergone transsphenoidal surgery for pituitary diseases in Peking Union Medical College Hospital between 2003 and 2017 was performed...
February 6, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29421453/adrenal-axis-insufficiency-following-endoscopic-transsphenoidal-resection-of-pituitary-adenomas
#19
Abdulrazag Ajlan, Khadeejah A Almufawez, Abdulrahman Albakr, Laurence Katznelson, Griffith R Harsh
INTRODUCTION: Hormonal insufficiency of one or more pituitary axes can appear after pituitary surgery. Adrenal axis impairment after surgery can lead to serious consequences if not identified and treated. OBJECTIVE: Assess early and late post-operative adrenal insufficiency (AI) and identify the risk factors predicting their occurrence after endoscopic transsphenoidal resection of pituitary adenomas. METHOD: Retrospective review identified 176 pituitary adenomas resected using an endoscopic transsphenoidal approach...
February 5, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29417847/clinical-outcomes-of-endoscopic-versus-microscopic-trans-sphenoidal-surgery-for-large-pituitary-adenoma
#20
Hamideh Akbari, Mojtaba Malek, Mohammad Ghorbani, Seyed Mahmoud Ramak Hashemi, Mohammad Ebrahim Khamseh, Ali Zare Mehrjardi, Zahra Emami, Ameneh Ebrahim Valojerdi
OBJECTIVE: To compare clinical outcomes of large pituitary adenomas (≥3 cm in maximum diameter), operated on by Endoscopic Transsphenoidal Surgery (ETS), versus Microscopic Transsphenoidal Surgery (MTS). METHODS: Medical records and MRI Scans of patients with a diagnosis of pituitary adenoma for whom transphenoidal surgery was done were reviewed. Complete pre and post-operative data were available for 121 patients. Thirty five patients had large pituitary adenoma and were enrolled in this study...
February 8, 2018: British Journal of Neurosurgery
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