keyword
https://read.qxmd.com/read/35862706/controlling-herpes-simplex-virus-induced-immunoinflammatory-lesions-using-metabolic-therapy-a-comparison-of-2-deoxy-d-glucose-with-metformin
#21
COMPARATIVE STUDY
Engin Berber, Barry T Rouse
Herpes simplex virus (HSV) infection of the eye can result in a blinding immunoinflammatory lesion in the cornea called herpetic stromal keratitis (HSK). This lesion is orchestrated by T cells and can be reduced in magnitude by anti-inflammatory drugs and procedures that change the balance of cellular participants in lesions. This report evaluates the effect of drugs that cause metabolic reprogramming on lesion expression using two drugs that affect glucose metabolism: 2-deoxy-d-glucose (2DG) and metformin...
July 27, 2022: Journal of Virology
https://read.qxmd.com/read/35817482/unusual-complication-of-herpes-simplex-encephalitis-complete-kl%C3%A3-ver-bucy-syndrome
#22
JOURNAL ARTICLE
Melissa Hernandez-Vega, Sandra Badial-Ochoa, Francisco Javier Rivas-Ruvalcaba, Ildefonso Rodriguez-Leyva
Klüver-Bucy syndrome is a rare neurobehavioral disorder caused by a bilateral temporal lobe lesion affecting the hippocampus and amygdala; clinically characterised by hyperorality, hypermetamorphosis, placidity, altered sexual behaviour, eating, disorders and visual impairment, agnosia and amnesia. However, the complete syndrome is rarely seen, and diagnosis does not require all the symptoms to be manifested simultaneously.We describe a patient who developed a complete Klüver-Bucy syndrome secondary to bilateral temporal involvement due to herpetic encephalitis...
July 11, 2022: BMJ Case Reports
https://read.qxmd.com/read/35766977/cd137-costimulation-is-associated-with-reduced-herpetic-stromal-keratitis-and-with-developing-normal-cd8-t-cells-in-trigeminal-ganglia
#23
JOURNAL ARTICLE
Xiao-Tang Yin, Nicholas K Baugnon, Rohini Krishnan, Chloe A Potter, Sudha Yarlagadda, Tammie L Keadle, Patrick M Stuart
Costimulatory interactions can be critical in developing immune responses to infectious agents. We recently reported that herpes simplex type 1 (HSV-1) infections of the cornea require a functional CD28-CD80/86 interaction to not only reduce the likelihood of encephalitis, but also to mediate herpetic stromal keratitis (HSK) following viral reactivation. In this same spirit we decided to determine the role that CD137 costimulation plays during HSK. Using both B6-CD137L-/- mice, as well as antagonistic and agonistic antibodies to CD137 we characterize the immune response and to what extent CD137 plays an important role during this disease...
June 2022: Journal of General Virology
https://read.qxmd.com/read/35685056/life-after-tetra-hit-anti-nmdar-encephalitis-after-hsv-encephalitis-in-a-nmosd-coexistent-with-sj%C3%A3-gren-s-syndrome
#24
Cansu Ayvacioğlu Çağan, Rahşan Göçmen, Nazire Pınar Acar Özen, Aslı Tuncer
Herpes simplex encephalitis (HSE) and anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis are associated entities. On the contrary, although both are autoimmune diseases, the association of neuromyelitis optica spectrum disorder (NMOSD) and anti-NMDAR encephalitis is not well explained. Herein, we present consecutively developed post-herpetic anti-NMDAR encephalitis in a patient with the coexistence of NMOSD and Sjogren syndrome. In our patient evaluation with MRI and clinical findings, the diagnosis of HSE after immunosuppressive drug application for NMOSD was made...
2022: Noro Psikiyatri Arsivi
https://read.qxmd.com/read/35662572/contribution-of-diffusion-weighted-imaging-to-distinguish-herpetic-encephalitis-from-auto-immune-encephalitis-at-an-early-stage
#25
JOURNAL ARTICLE
Alexandre Bani-Sadr, Marie-Camille Ruitton-Allinieu, Jean-Christophe Brisset, François Ducray, Bastien Joubert, Géraldine Picard, François Cotton
OBJECTIVES: To determine whether diffusion-weighted imaging (DWI) can help to distinguish early stage autoimmune (AI) and herpes simplex virus (HSV) encephalitides. METHODS: This case-control study included patients from a multi-center cohort of AI encephalitides whose initial MRI including DWI was performed within ten days after symptoms onset. They were compared with patients with HSV encephalitis enrolled prospectively in a single-center from June, 2020 to December, 2020...
May 31, 2022: Journal of Neuroradiology. Journal de Neuroradiologie
https://read.qxmd.com/read/35645381/kyrieleis-arteriolitis-associated-with-acute-retinal-necrosis-due-to-herpes-simplex-virus-type-1-secondary-to-herpetic-encephalitis
#26
Olga E Makri, Iasonas K Tsekouras, Leonidia Leonidou, Konstantinos Kagkelaris, Vassilios Kozobolis, Constantinos D Georgakopoulos
We report the case of a 52-year-old woman who presented to the emergency department with acute retinal necrosis in her left eye secondary to herpes simplex virus type 1 encephalitis for which she had been hospitalized four months before. Treatment with intravitreal foscarnet and intravenous acyclovir was promptly commenced followed by the addition of oral prednisolone. PCR analysis of aqueous humor detected HSV type 1 DNA. The condition responded to therapy with partial resolution of intraocular inflammation and improvement of visual acuity, but the presence of Kyrieleis plaques was observed two weeks after the initiation of treatment, when five intravitreal foscarnet injections had been administered...
May 18, 2022: Vision
https://read.qxmd.com/read/35632613/surveillance-of-viral-encephalitis-in-the-context-of-covid-19-a-one-year-observational-study-among-hospitalized-patients-in-dakar-senegal
#27
JOURNAL ARTICLE
Jamil Kahwagi, Al Ousseynou Seye, Ahmadou Bamba Mbodji, Rokhaya Diagne, El Hadji Mbengue, Maouly Fall, Soa Fy Andriamandimby, Ava Easton, Martin Faye, Gamou Fall, Ndongo Dia, Babacar Ndiaye, Momo Banda Ndiaye, Alle Gueye, Serigne Saliou Mbacke, Fatou Kane, Mohamed Inejih El Ghouriechy, Ensene Investigators, Lala Bouna Seck, Ndiaga Matar Gaye, Amadou Alpha Sall, Moustapha Ndiaye, Ousmane Faye, Amadou Gallo Diop, Jean-Michel Heraud
The burden of encephalitis and its associated viral etiology is poorly described in Africa. Moreover, neurological manifestations of COVID-19 are increasingly reported in many countries, but less so in Africa. Our prospective study aimed to characterize the main viral etiologies of patients hospitalized for encephalitis in two hospitals in Dakar. From January to December 2021, all adult patients that met the inclusion criteria for clinical infectious encephalitis were enrolled. Cerebrospinal fluids, blood, and nasopharyngeal swabs were taken and tested for 27 viruses...
April 22, 2022: Viruses
https://read.qxmd.com/read/35119328/herpesviral-encephalitis-associated-with-bortezomib-use-in-a-patient-with-multiple-myeloma-and-associated-light-chain-amyloidosis
#28
JOURNAL ARTICLE
David Garrido, Eloísa Riva
INTRODUCTION: Bortezomib is proteasome inhibitor used in multiple myeloma treatment. The reactivation of herpes simplex virus (HSV) and varicella-zoster virus (VZV) during bortezomib-based therapy is a well-known adverse event. Antiviral prophylaxis is mandatory. Nevertheless, reports of herpesviral encephalitis are scarce. CASE REPORT: A 57-year-old multiple myeloma patient who during CyBorD protocol (Bortezomib, cyclophosphamide, and dexamethasone), after a transient suspension of antiviral prophylaxis presented progressive headaches unresponsive to conventional analgesics, asthenia, fever, episodic visual hallucinations, and vesicular lesions in the right supraorbital and frontal region...
October 2022: Journal of Oncology Pharmacy Practice
https://read.qxmd.com/read/35099587/herpetic-encephalitis-which-treatment-for-which-body-weight
#29
JOURNAL ARTICLE
Marine Mulatero, Mohamed Boucekine, Olivier Felician, Salah Boussen, Gilles Kaplanski, Pascal Rossi, Philippe Parola, Andréas Stein, Philippe Brouqui, Jean Christophe Lagier, Marc Leone, Elsa Kaphan
BACKGROUND: Prognosis of herpetic encephalitis remains severe, with a high proportion of deaths and sequelae. Its treatment is based on acyclovir, but the precise and most effective modalities of this treatment are not established. The objective of this study was to determine them. METHODS: For this, we carried out a descriptive, retrospective, monocentric study, using the current coding database at Marseille University Hospitals. Cohort was intended to be exhaustive for the disease, from January 2000 to June 2019, including patients hospitalized in intensive care and conventional hospitalization sector...
July 2022: Journal of Neurology
https://read.qxmd.com/read/35060810/granulomatous-herpetic-encephalitis-a-possible-role-for-inflammasomes
#30
JOURNAL ARTICLE
Brendan McKenna, Caitlin Malone, Ashirwad Merwe, Gopinathan Kathirvelu, Kshitij Mankad
BACKGROUND: Granulomatous herpetic encephalitis is a rare inflammatory complication of acute herpes simplex encephalitis. METHODS: We describe 3 cases of granulomatous herpetic encephalitis in children arising between 1 to 10 years after the initial presentation with acute herpes simplex encephalitis. We focus on the clinical course and neuroimaging phenotype with a discussion of possible mechanisms underpinning this entity. RESULTS: The clinical course was highly variable...
January 21, 2022: Journal of Child Neurology
https://read.qxmd.com/read/34981436/cerebral-vasculitis-caused-by-talaromyces-marneffei-and-aspergillus-niger-in-a-hiv-positive-patient-a-case-report-and-literature-review
#31
JOURNAL ARTICLE
Yidong Gao, Man Qu, Chao Song, Lufeng Yin, Min Zhang
Cerebral vasculitis is a long-standing but flourishing and fadeless research topic. Infections are a frequent cause of cerebral vasculitis, vital to diagnose due to involvement of specific anti-infection treatments. A 65-year-old man visited the hospital for his neurological symptoms without obvious inducements. After admission, radiological examination and comprehensive conventional microbiological tests (CMTs) revealed suspected intracranial infectious vasculitis. Metagenomic next-generation sequencing (mNGS) and reverse transcription-polymerase chain reaction further confirmed that his cerebral vasculitis was caused by Talaromyces marneffei (T...
January 3, 2022: Journal of Neurovirology
https://read.qxmd.com/read/34970721/detection-of-human-herpesviruses-in-cerebrospinal-fluids-collected-from-patients-suspected-of-neuroinfectious-diseases
#32
JOURNAL ARTICLE
Soichiro Ishimaru, Yoshiki Kawamura, Hiroki Miura, Sayuri Shima, Akihiro Ueda, Hirohisa Watanabe, Tatsuro Mutoh, Tetsushi Yoshikawa
The full spectrum of human herpesviruses (HHV)-associated neuroinfectious diseases in immunocompetent adults remains unclear. Hence, we sought to elucidate the epidemiology and clinical features of these diseases. The study subjects were patients over 16 years old suspected of neuroinfectious diseases who underwent spinal tap performed by neurologists in our university hospital between April 2013 and March 2018. The presence of seven HHV DNAs in cerebrospinal fluid (CSF) was determined by real-time PCR...
February 2022: Journal of Neurovirology
https://read.qxmd.com/read/34781140/lessons-from-epstein-barr-virus-dna-detection-in-cerebrospinal-fluid-as-a-diagnostic-tool-for-ebv-induced-central-nervous-system-dysfunction-among-hiv-positive-patients
#33
REVIEW
Yanli Wang, Jun Yang, Ying Wen
Polymerase chain reaction (PCR) analysis of Epstein-Barr virus (EBV) DNA in cerebrospinal fluid (CSF) remains vital for evaluating active EBV infection involving the central nervous system (CNS). CSF EBV DNA was often found in conjunction with other microbial infection affecting the CNS among patients infected with human immunodeficiency virus (HIV). Sometimes CSF EBV DNA is detectable in patients without neurological symptoms. This review focused on the clinical and laboratory features of CNS EBV infection among patients with HIV, and discussed various types of EBV-associated CNS infections, and predominant neoplasms involving CNS such as primary central nervous system lymphoma (PCNSL), CNS-non-Hodgkin's lymphoma, smooth muscle tumors and leiomyosarcomas, EBV encephalitis or myelitis, EBV meningitis and EBV coinfection with other causative agents were also included...
January 2022: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/34709694/clinical-neuropathological-and-immunological-short-and-long-term-feature-of-a-mouse-model-mimicking-human-herpes-virus-encephalitis
#34
JOURNAL ARTICLE
Julia Sehl-Ewert, Theresa Schwaiger, Alexander Schäfer, Julia E Hölper, Barbara G Klupp, Jens P Teifke, Ulrike Blohm, Thomas C Mettenleiter
Herpes simplex encephalitis (HSE) is one of the most serious diseases of the nervous system in humans. However, its pathogenesis is still only poorly understood. Although several mouse models of predominantly herpes simplex virus 1 (HSV-1) infections mimic different crucial aspects of HSE, central questions remain unanswered. They comprise the specific temporofrontal tropism, viral spread within the central nervous system (CNS), as well as potential molecular and immunological barriers that drive virus into latency while only rarely resulting in severe HSE...
May 2022: Brain Pathology
https://read.qxmd.com/read/34688092/anti-n-methyl-d-aspartate-receptor-encephalitis-an-observational-and-comparative-study-in-mexican-children-and-adults
#35
MULTICENTER STUDY
Patricia Herrera-Mora, Leticia Munive-Baez, Matilde Ruiz García, Alfredo Galindo-Martínez, Daniela Ellis Maldonado-Diaz, Rosa Delia Delgado, Graciela Cárdenas
OBJECTIVE: To present a case series of encephalitis patients with anti-N-methyl-D-aspartate receptor antibodies, attending two neurological referral centers in a three-year period. METHODS: A retrospective, descriptive, comparative study included child and adult patients in two neurological populations, positive for antibodies against the NR1 and NR2 subunits of the glutamate (NMDA) receptor in serum and CSF, as determined during a three-year period. RESULTS: Sixty-six patients were included (40 children and 26 adults)...
November 2021: Clinical Neurology and Neurosurgery
https://read.qxmd.com/read/34616813/agranulocytosis-following-injection-of-inactivated-japanese-encephalitis-vaccine-vero-cell-a-case-report
#36
Li Wang, Xu Zhang, Yan-Tao Liu
BACKGROUND: Japanese encephalitis virus (JEV), a mosquito borne flavivirus, is the leading cause of viral encephalitis in Asia, in terms of frequency and severity. JEV infection is thought to confer lifelong immunity. With the near eradication of poliomyelitis, JEV is now the continent's leading cause of childhood viral neurologic infection and disability. The most common clinical manifestation of JEV infection is acute encephalitis, and currently there is no specific antiviral therapy...
September 6, 2021: World Journal of Clinical Cases
https://read.qxmd.com/read/34576791/herpes-simplex-virus-re-activation-in-patients-with-sars-cov-2-pneumonia-a-prospective-observational-study
#37
JOURNAL ARTICLE
Erica Franceschini, Alessandro Cozzi-Lepri, Antonella Santoro, Erica Bacca, Guido Lancellotti, Marianna Menozzi, William Gennari, Marianna Meschiari, Andrea Bedini, Gabriella Orlando, Cinzia Puzzolante, Margherita Digaetano, Jovana Milic, Mauro Codeluppi, Monica Pecorari, Federica Carli, Gianluca Cuomo, Gaetano Alfano, Luca Corradi, Roberto Tonelli, Nicola De Maria, Stefano Busani, Emanuela Biagioni, Irene Coloretti, Giovanni Guaraldi, Mario Sarti, Mario Luppi, Enrico Clini, Massimo Girardis, Inge C Gyssens, Cristina Mussini
BACKGROUND: Herpes simplex 1 co-infections in patients with COVID-19 are considered relatively uncommon; some reports on re-activations in patients in intensive-care units were published. The aim of the study was to analyze herpetic re-activations and their clinical manifestations in hospitalized COVID-19 patients, performing HSV-1 PCR on plasma twice a week. METHODS: we conducted a prospective, observational, single-center study involving 70 consecutive patients with severe/critical SARS-CoV-2 pneumonia tested for HSV-1 hospitalized at Azienda Ospedaliero-Universitaria of Modena...
September 7, 2021: Microorganisms
https://read.qxmd.com/read/34548521/a-novel-bioluminescent-herpes-simplex-virus-1-for-in-vivo-monitoring-of-herpes-simplex-encephalitis
#38
JOURNAL ARTICLE
Olus Uyar, Pier-Luc Plante, Jocelyne Piret, Marie-Christine Venable, Julie Carbonneau, Jacques Corbeil, Guy Boivin
Herpes simplex virus 1 (HSV-1) is responsible for herpes simplex virus encephalitis (HSE), associated with a 70% mortality rate in the absence of treatment. Despite intravenous treatment with acyclovir, mortality remains significant, highlighting the need for new anti-herpetic agents. Herein, we describe a novel neurovirulent recombinant HSV-1 (rHSV-1), expressing the fluorescent tdTomato and Gaussia luciferase (Gluc) enzyme, generated by the Clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (Cas9) (CRISPR-Cas9) system...
September 21, 2021: Scientific Reports
https://read.qxmd.com/read/34522478/an-infant-with-seborrhoeic-dermatitis-and-eczema-herpeticum-complicated-by-a-generalized-infection
#39
Katarzyna Karpierz, Ernest P Kuchar
Primary herpes simplex virus 1 (HSV-1) infection in children (beyond the neonatal period) may be asymptomatic or manifest as herpetic gingivostomatitis accompanied by fever and other symptoms. However, severe, health- and life-threatening infection is observed in rare cases, especially in at-risk patients. Children with atopic dermatitis may develop extensive eczema herpeticum ( eruptio varicelliformis Kaposi ). Herpes simplex eye infection, herpes simplex encephalitis, and disseminated (generalized) herpes infection also pose danger...
August 2021: Curēus
https://read.qxmd.com/read/34452501/rational-design-of-live-attenuated-vaccines-against-herpes-simplex-viruses
#40
REVIEW
Brent A Stanfield, Konstantin G Kousoulas, Agustin Fernandez, Edward Gershburg
Diseases caused by human herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) affect millions of people worldwide and range from fatal encephalitis in neonates and herpes keratitis to orofacial and genital herpes, among other manifestations. The viruses can be shed efficiently by asymptomatic carriers, causing increased rates of infection. Viral transmission occurs through direct contact of mucosal surfaces followed by initial replication of the incoming virus in skin tissues. Subsequently, the viruses infect sensory neurons in the trigeminal and lumbosacral dorsal root ganglia, where they are primarily maintained in a transcriptionally repressed state termed "latency", which persists for the lifetime of the host...
August 18, 2021: Viruses
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