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herpetic encephalitis

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https://www.readbyqxmd.com/read/27681121/immune-and-nonimmune-compartment-specific-interferon-responses-are-critical-determinants-of-herpes-simplex-virus-induced-generalized-infections-and-acute-liver-failure
#1
Zachary M Parker, Tracy Jo Pasieka, George A Parker, David A Leib
: The interferon (IFN) response to viral pathogens is critical for host survival. In humans and mouse models, defects in IFN responses can result in lethal herpes simplex virus 1 (HSV-1) infections, usually from encephalitis. Although rare, HSV-1 can also cause fulminant hepatic failure, which is often fatal. Although herpes simplex encephalitis has been extensively studied, HSV-1 generalized infections and subsequent acute liver failure are less well understood. We previously demonstrated that IFN-αβγR(-/-) mice are exquisitely susceptible to liver infection following corneal infection with HSV-1...
December 1, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27577846/acute-retinal-necrosis-results-in-low-vision-in-a-young-patient-with-a-history-of-herpes-simplex-virus-encephalitis
#2
Sanjeet K Shahi
Acute retinal necrosis (ARN), secondary to herpes simplex encephalitis, is a rare syndrome that can present in healthy individuals, as well as immuno-compromised patients. Most cases are caused by a secondary infection from the herpes virus family, with varicella zoster virus being the leading cause of this syndrome. Potential symptoms include blurry vision, floaters, ocular pain and photophobia. Ocular findings may consist of severe uveitis, retinal vasculitis, retinal necrosis, papillitis and retinal detachment...
August 31, 2016: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/27315001/-recurrent-encephalitis-following-annual-influenza-vaccine-case-report
#3
Bernardita González, Alberto Fica
Influenza vaccine is rarely associated with neurological adverse effects such as Guillain Barré syndrome, encephalitis or aseptic meningitis. We report the case of a male patient that presented two episodes of acute encephalitis in consecutive years, 16 and 20 days after his annual influenza vaccine shot, respectively. In both instances, patient required ICU admission and evolved with fast recovery and no sequels. The first episode was managed empirically as herpetic encephalitis but an extensive study was performed in the second episode without identifying any microorganism...
April 2016: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/27191471/acute-retinal-necrosis-presenting-in-developmentally-delayed-patients-with-neonatal-encephalitis-a-case-series-and-literature-review
#4
Kingsley Okafor, Jonathan Liu, Sumeer Thinda, Ivan Schwab, Lawrence S Morse, Susanna S Park, Ala Moshiri
We report three cases of patients with developmental-delay from neonatal herpetic encephalitis and/or meningitis who presented years later with acute retinal necrosis due to herpes simplex virus. The diagnosis was delayed in all cases due to the patients' inability to verbalize their ocular complaints and cooperate with eye examinations. This case series documents the clinical course, pathophysiologic mechanism, and treatment of acute retinal necrosis in this patient population. Clinicians should understand the importance of prudent consideration of acute retinal necrosis in patients with a history of neonatal herpetic encephalitis and/or meningitis presenting with a red eye...
May 18, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27106239/herpes-simplex-virus-1-encephalitis-in-adults-pathophysiology-diagnosis-and-management
#5
REVIEW
Michael J Bradshaw, Arun Venkatesan
Herpetic infections have plagued humanity for thousands of years, but only recently have advances in antiviral medications and supportive treatments equipped physicians to combat the most severe manifestations of disease. Prompt recognition and treatment can be life-saving in the care of patients with herpes simplex-1 virus encephalitis, the most commonly identified cause of sporadic encephalitis worldwide. Clinicians should be able to recognize the clinical signs and symptoms of the infection and familiarize themselves with a rational diagnostic approach and therapeutic modalities, as early recognition and treatment are key to improving outcomes...
July 2016: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/27099786/study-of-antiherpetic-efficiency-of-phosphite-of-acycloguanosine-ableto-over-come-the-barrier-of-resistance-to-acyclovir
#6
V L Andronova, M V Jasko, M K Kukhanova, G A Galegov, Yr S Skoblov, S N Kochetkov
As has been shown previously, phosphite of acycloguanosine (Hp-ACG) exhibits equal efficacy against ACV-sensitive and ACV-resistant HSV-1 strains in cell culture. Intraperitoneal administration of Hp-ACG to model mice with herpetic encephalitis caused by HSV-1 infection was shown to be effective in protecting against death. In the present work, we continue the study of the antiviral efficiency of Hp-ACG against HSV administered non-invasively; namely in vivo, orally and in the form of ointment formulations...
January 2016: Acta Naturae
https://www.readbyqxmd.com/read/27085724/managing-atypical-and-typical-herpetic-central-nervous-system-infections-results-of-a-multinational-study
#7
Y Cag, H Erdem, S Leib, S Defres, S Kaya, L Larsen, M Poljak, D Ozturk-Engin, B Barsic, X Argemi, S M Sørensen, A L Bohr, P Tattevin, J D Gunst, L Baštáková, M Jereb, I S Johansen, O Karabay, A U Pekok, O R Sipahi, M Chehri, G Beraud, G Shehata, R Fontana, M Maresca, H Karsen, G Sengoz, M Sunbul, G Yilmaz, H Yilmaz, A Sharif-Yakan, S Kanj, E Parlak, F Pehlivanoglu, F Korkmaz, S Komur, S Kose, M Ulug, S Bolukcu, S A Coskuner, J P Stahl, N Ince, Y Akkoyunlu, G Halac, E Sahin-Horasan, H Tireli, G Kilicoglu, A Al-Mahdawi, S A Nemli, A Inan, S Senbayrak, H Vahaboglu, N Elaldi
There have been many studies pertaining to the management of herpetic meningoencephalitis (HME), but the majority of them have focussed on virologically unconfirmed cases or included only small sample sizes. We have conducted a multicentre study aimed at providing management strategies for HME. Overall, 501 adult patients with PCR-proven HME were included retrospectively from 35 referral centres in 10 countries; 496 patients were found to be eligible for the analysis. Cerebrospinal fluid (CSF) analysis using a PCR assay yielded herpes simplex virus (HSV)-1 DNA in 351 patients (70...
June 2016: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/26995500/relapsing-polychondritis-and-lymphocytic-meningitis-with-varied-neurological-symptoms
#8
Renata Dal-Prá Ducci, Francisco Manoel Branco Germiniani, Letícia Elizabeth Augustin Czecko, Eduardo S Paiva, Hélio Afonso Ghizoni Teive
BACKGROUND: Relapsing polychondritis is a rare multisystem disease characterized by bilateral auricular and nasal chondritis and vestibular involvement, additionally affecting various other organs/systems. However, Central Nervous System involvement has only been reported in a few instances. OBJECTIVE: To report the case of a patient with relapsing polychondritis and several neurological manifestations. CASE REPORT: We report the case of a 69 year-old male with a 20-day history of ataxia, paraparesis, tinnitus, vertigo and confusion...
February 5, 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/26988237/herpes-simplex-virus-1-encephalitis-induced-by-chemoradiotherapy-and-steroids-in-an-esophageal-cancer-patient-a-case-report
#9
Masaaki Saito, Hirokazu Kiyozaki, Tamotu Obitsu, Hirofumi Imoto, Yusuke Taniyama, Osamu Takata, Toshiki Rikiyama
BACKGROUND: Systemic chemotherapy combined with steroids used as prophylactic antiemetics have been reported to induce immunosuppression. Further, herpes simplex virus-1 (HSV-1) infection has been reported to occur in patients with small cell carcinomas after chemoradiotherapy that includes brain irradiation. Here, we report a case of HSV-1 encephalitis that occurred in a patient undergoing chemoradiotherapy for advanced esophageal cancer. CASE PRESENTATION: A 77-year-old woman received chemoradiotherapy (5-fluorouracil, 700 mg/m(2); cisplatin, 70 mg/m(2); and radiotherapy, 60 Gy in total) for stage III esophageal cancer...
2016: BMC Cancer
https://www.readbyqxmd.com/read/26958155/recurrent-transcortical-motor-aphasia-another-cns-infectious-syndrome-associated-with-herpes-virus-infection
#10
Raghav Govindarajan, Efrain Salgado
Herpes simplex encephalitis is an acute/subacute illness that causes both general and focal signs of cerebral dysfunction with fever, headache, and confusion as cardinal features. Recurrent herpes simplex meningitis, also known as Mollaret's meningitis, is another manifestation of central nervous system herpetic infection with recurrent episodes of fever, headache, and nuchal rigidity associated with cerebrospinal fluid (CSF) evidence of active herpes simplex infection. Bell's palsy is yet another manifestation of a herpes virus infection in at least some reported cases documented by CSF analysis...
January 2016: Journal of Vascular and Interventional Neurology
https://www.readbyqxmd.com/read/26709736/simultaneous-detection-and-genotype-determination-of-hsv-1-and-2-by-real-time-pcr-using-melting-curve-analysis-and-a-unique-pair-of-primers
#11
Mahdi Paryan, Samira Mohammadi-Yeganeh, Houri Rezvan, Vahid Kia, Ardalan Mansouri, Siamak Mirab Samiee
Herpes simplex virus (HSV) is a human pathogen that causes different pathologic manifestations. Rapid and feasible detection and discrimination methods for HSV genotyping is a challenge in clinical laboratories, especially in children suffering from herpetic encephalitis. A quantitative real-time polymerase chain reaction (PCR)-based genotyping assay using SYBR Green I was established. We designed only 1 pair of primer for HSV 1 and 2, targeting thymidine kinase gene conserved region. HSV genotypes were determined by PCR using melting curve analysis with LightCycler...
December 24, 2015: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/26691173/phase-ii-study-of-capecitabine-in-substitution-of-5-fu-in-the-chemoradiotherapy-regimen-for-patients-with-localized-squamous-cell-carcinoma-of-the-anal-canal
#12
Suilane Coelho Ribeiro Oliveira, Camila Motta Venchiarutti Moniz, Rachel Riechelmann, Alexandra Kichfy Alex, Maria Ignez Braghirolli, Giovanni Bariani, Caio Nahas, Paulo Marcelo Gehm Hoff
UNLABELLED: This was a phase II study of capecitabine in substitution of 5-fluorouracil (5-FU) in the chemoradiotherapy regimen for patients with localized squamous cell carcinoma of the anal canal. BACKGROUND: Combined chemoradiation with infusional 5-FU and mitomycin is the standard treatment for localized squamous cell carcinoma (SCC) of the anal canal. Capecitabine is an oral fluoropirimidine that has been shown to be equally effective to 5-FU in many solid tumors...
March 2016: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/26669609/effects-of-rna-interference-therapy-against-herpes-simplex-virus-type-1-encephalitis
#13
Alexandre S da Silva, Jéssica V Raposo, Tiago C Pereira, Marcelo A Pinto, Vanessa S de Paula
BACKGROUND: Herpetic encephalitis (HSE) is caused mainly by herpes simplex virus type 1 (HSV-1) with an annual incidence of 1-4 cases/million inhabitants. Currently, HSE treatment faces difficulties such as the use of antivirals with elevated toxicity, metabolic side effects and HSV-1 resistance. An alternative to antivirals is the use of small interfering RNA (siRNA) as a viral replication inhibitor. In this work, siRNA targeting the UL-39 region was evaluated for HSE treatment in vivo...
2016: Antiviral Therapy
https://www.readbyqxmd.com/read/26445122/periodic-lateralized-epileptiform-discharges-pleds-in-herpetic-encephalitis
#14
William Alves Martins, André Palmini
No abstract text is available yet for this article.
December 2015: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/26230431/-clinical-characteristics-of-adult-patients-with-herpetic-meningoencephalitis-a-nested-case-control-study
#15
María de Las Mercedes Magaz, Vanna Wainsztein, Joaquín Maritano, María Nelly Gutiérrez, Fernando Binder, Bruno L Ferreyro, Federico Angriman, Gabriel Waisman
INTRODUCTION: Herpes simplex virus (HSV) is the most common etiology of sporadic encephalitis and presents with an estimated mortality of 50-70%. OBJECTIVE: To describe baseline characteristics of patients with herpetic encephalitis admitted to a tertiary teaching hospital and their difference with patients with non herpetic encephalitis. MATERIALS AND METHODS: Nested case control study using a retrospective cohort of patients with suspected encephalitis admitted to the Hospital Italiano de Buenos Aires (2006-2013)...
June 2015: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/26216066/-post-herpes-simplex-encephalitis-chorea-viral-replication-or-immunological-mechanism
#16
H Benrhouma, A Nasri, I Kraoua, H Klaa, I Turki, N Gouider-Khouja
INTRODUCTION: Herpes simplex encephalitis is a severe neurological condition, whose outcome is improved if treated early with acyclovir. Post-herpes simplex encephalitis with acute chorea has rarely been reported. CASE REPORT: We report on two observations of children presenting with post-herpes simplex encephalitis with acute chorea, related to two different pathophysiological mechanisms. The first one is an 11-month-old girl developing relapsing herpes simplex encephalitis with chorea due to resumption of viral replication...
September 2015: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/26103811/-a-case-of-bilateral-auricular-chondritis-with-anti-glutamate-receptor-glur%C3%AE%C2%B52-antibody-positive-non-herpetic-acute-limbic-encephalitis
#17
Ryo Nishiguchi, Takeshi Fujimoto, Katsumi Eguchi, Yasuo Fukuda, Yukitoshi Takahashi
A 62-year-old man experienced pain and swelling in both of his auricles. One and a half months later, he was referred to us because of a memory disturbance. A neurological examination revealed disorientation and recent memory impairment. Diffusion-weighted and fluid-attenuated inversion recovery magnetic resonance images showed high intensity and swelling lesions in the bilateral medial temporal regions. In cerebrospinal fluid, mononuclear cell counts and total protein concentration were increased, but a herpes polymerase chain reaction was negative...
2015: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/26001830/a-man-with-an-infected-finger-a-case-report
#18
Pieter J Gathier, Titus J A Schönberger
INTRODUCTION: Whitlow is an infection of a finger or around the fingernails, generally caused by bacterium. However, in rare cases, it may also be caused by the herpes simplex virus. As herpetic whitlow is not seen often, it may go under-recognised or be mistaken for a different kind of infection of the finger. Delayed recognition and/or treatment puts patients at risk of complications ranging from superinfection to herpetic encephalitis. CASE PRESENTATION: A 23-year-old Caucasian man with no medical history was referred by his primary care physician because of erythema and swelling of the little finger of his left hand...
May 23, 2015: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/25883839/herpes-simplex-reactivation-or-postinfectious-inflammatory-response-after-epilepsy-surgery-case-report-and-review-of-the-literature
#19
Anna Lo Presti, Alexander G Weil, Toba N Niazi, Sanjiv Bhatia
BACKGROUND: Herpes simplex virus encephalitis (HSVE) is the most morbid clinical syndrome associated with the human herpes virus. Despite treatment with appropriate dosages of acyclovir, neurologic relapse of HSV infection have been reported after cranial surgery. Rarely, neurological deterioration due to postinfectious inflammatory response without demonstrable HSV reactivation may recur following cranial surgery. CASE DESCRIPTION: We report a case of a 17-year-old girl who presented with a HSVE relapse on the 6(th) postoperative day following resective surgery for medically refractory epilepsy and review the literature...
2015: Surgical Neurology International
https://www.readbyqxmd.com/read/25856282/autophagy-stimulation-abrogates-herpes-simplex-virus-1-infection
#20
Abraam M Yakoub, Deepak Shukla
Herpes simplex virus-1 (HSV-1) is a double-stranded DNA virus that causes life-long infections. HSV-1 infections may lead to herpetic stromal keratitis that may advance to corneal blindness. HSV-1 infections can also cause fatal conditions, such as herpes encephalitis, or neonatal disease. A major virulence mechanism of HSV-1 is the control of autophagy, an innate immune defense strategy that could otherwise degrade viral particles. Here, to investigate a new mechanism for antiviral therapy, we tested the effect of various autophagy inducers (physiological and pharmacological) on infection...
April 9, 2015: Scientific Reports
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