Patrick M Sleiman, Hui-Qi Qu, John J Connolly, Frank Mentch, Alexandre Pereira, Paulo A Lotufo, Stephen Tollman, Ananyo Choudhury, Michele Ramsay, Norihiro Kato, Kouichi Ozaki, Risa Mitsumori, Jae-Pil Jeon, Chang Hyung Hong, Sang Joon Son, Hyun Woong Roh, Dong-Gi Lee, Naaheed Mukadam, Isabelle F Foote, Charles R Marshall, Adam Butterworth, Bram P Prins, Joseph T Glessner, Hakon Hakonarson
BACKGROUND: As a collaboration model between the International HundredK+ Cohorts Consortium (IHCC) and the Davos Alzheimer's Collaborative (DAC), our aim was to develop a trans-ethnic genomic informed risk assessment (GIRA) algorithm for Alzheimer's disease (AD). METHODS: The GIRA model was created to include polygenic risk score calculated from the AD genome-wide association study loci, the apolipoprotein E haplotypes, and non-genetic covariates including age, sex, and the first three principal components of population substructure...
July 14, 2023: Alzheimer's & Dementia: the Journal of the Alzheimer's Association