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melanoma anesthesia

Julius Höhne, Christoph Hohenberger, Martin Proescholdt, Markus J Riemenschneider, Christina Wendl, Alexander Brawanski, Karl-Michael Schebesch
BACKGROUND: Cerebral metastasis (CM) is the most common malignancy affecting the brain. In patients eligible for surgery, complete tumor removal is the most important predictor of overall survival and neurological outcome. The emergence of surgical microscopes fitted with a fluorescein-specific filter have facilitated fluorescein-guided microsurgery and identification of tumor tissue. In 2012, we started evaluating fluorescein (FL) with the dedicated microscope filter in cerebral metastases (CM)...
February 2017: Acta Neurochirurgica
Ding-Kun Kang, Li-Yan Zhao, Hong-Li Wang
BACKGROUND: Local anesthetics (LAs) are generally considered as safe, but cytotoxicity has been reported for several local anesthetics used in humans, which is not well investigated. In the present study, the cytotoxicity of lidocaine, ropivacaine and the combination of lidocaine and ropivacaine were evaluated on human melanoma cell lines. Melphalan, a nitrogen mustard alkylating agent, was used as a control agent for comparison of cytotoxic activity. METHODS: Melanoma cell lines, A375 and Hs294T, were exposed to 1h to different concentrations of above agents...
November 2016: Brazilian Journal of Anesthesiology
James W Behan, Adam Sutton, Ashley Wysong
Skin cancer is the most common of human cancers and outnumbers all other types of cancer combined in the USA by over threefold. The majority of non-melanoma skin cancers are easily treated with surgery or locally destructive techniques performed under local anesthesia in the cost-effective outpatient setting. However, there is a subset of "high-risk" cases that prove challenging in terms of morbidity, mortality, adjuvant treatment required, as well as overall cost to the health care system. In our opinion, the term "high risk" when applied to skin cancer can mean one of three things: a high-risk tumor with aggressive histologic and/or clinical features with an elevated risk for local recurrence or regional/distant metastasis, a high-risk patient with the ongoing development of multiple skin cancers, and a high-risk patient based on immunosuppression...
December 2016: Current Treatment Options in Oncology
Mansi Patel, HyunJi Boo, Suganthi Kandasamy, Dhagash Patel, Anthony Iorio
INTRODUCTION AND OBJECTIVES: Melanoma is one of the most common primary malignant tumors arising in the lower extremity. It is crucial to diagnose melanoma as quickly and as efficiently as possible for a better prognosis. The use of dermoscopy is helpful in diagnosing such conditions. Dermoscopy is a non-invasive, in-vivo technique primarily used in the examination of pigmented skin lesions. This procedure allows the visualization of subsurface skin structures in the epidermis, dermoepidermal junction, and upper dermis - structures not visible to the naked eye...
September 2016: Journal of the American Podiatric Medical Association
Ding-Kun Kang, Li-Yan Zhao, Hong-Li Wang
BACKGROUND: Local anesthetics (LAs) are generally considered as safe, but cytotoxicity has been reported for several local anesthetics used in humans, which is not well investigated. In the present study, the cytotoxicity of lidocaine, ropivacaine and the combination of lidocaine and ropivacaine were evaluated on human melanoma cell lines. Melphalan, a nitrogen mustard alkylating agent, was used as a control agent for comparison of cytotoxic activity. METHODS: Melanoma cell lines, A375 and Hs294T, were exposed to 1h to different concentrations of above agents...
September 14, 2016: Revista Brasileira de Anestesiologia
Sabrina N Pavri, James Clune, Stephan Ariyan, Deepak Narayan
LEARNING OBJECTIVES: After reading this article, the participant should be able to: 1. Discuss the initial management of cutaneous malignant melanoma with regard to diagnostic biopsy and currently accepted resection margins. 2. Be familiar with the management options for melanoma in specific situations such as subungual melanoma, auricular melanoma, and melanoma in the pregnant patient. 3. Discuss the differentiating characteristics of desmoplastic melanoma and its treatment options. 4...
August 2016: Plastic and Reconstructive Surgery
Diana Crisan, Nicolai Treiber, Thomas Kull, Peter Widschwendter, Oliver Adolph, Lars Alexander Schneider
A tumor primarily requiring surgical treatment, newly diagnosed or preexisting melanoma during pregnancy is a clinical rarity. In such cases, the surgeon faces the challenge of having to decide on the appropriate therapeutic course of action. Based on our clinical experience and a review of the literature, we herein provide a guideline on how to practically deal with this rare clinical conundrum. In our experience, pregnant melanoma patients require thorough counseling with respect to their therapeutic options...
June 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
O Šedivý, A Fibír, I Slaninka
No abstract text is available yet for this article.
2015: Acta Chirurgiae Plasticae
Uwe Wollina
The face is a common localization for skin malignancies. Mohs surgery or delayed Mohs surgery are considered the gold standard of treatment despite new drug developments. We analyzed our patient files over a three-year period. Only large facial defects ≥3 cm in diameter after complete tumor removal were considered. Twenty patients (9 men and 11 women) were found, with a mean age of 83.6 years. The following tumor entities were responsible for large defects: basal and squamous cell carcinoma, melanoma, Merkel cell carcinoma, atypical fibroxanthoma, and cutaneous angiosarcoma...
2015: Acta Dermatovenerologica Croatica: ADC
Bingjun Yang, Qingzhao Li, Hui Zhao, Huibin Liu, Tao Tang, Chunyang Jiang
BACKGROUND: Oral malignant melanoma (OMM) is an aggressive tumor with very low survival rate and easy to metastasize. Pleural metastatic melanoma via primary OMM is rare. CASE PRESENTATION: In this report, we presented a case of metastatic malignant melanoma of the pleura originated from OMM. A 54-year-old man without primary skin lesion was diagnosed multiple nodular shadows, pleural invasion, and pleural effusion by chest computed tomography (CT). One cyst-form tumor on the tongue base was observed by bronchoscopy, which was diagnosed as OMM by pathological examination and then was resected...
2015: World Journal of Surgical Oncology
Pulsar Li, J Wallis Marsh, Charles D Boucek
We report the perioperative management of a patient with melanoma. Surgical intervention was withheld at multiple institutions because of the presence of metastases; the patient was undergoing experimental immunotherapy and had responded everywhere except in the liver. She underwent hepatic right trisegmentectomy to improve her quality of life and to allow resumption of immunotherapy. Dyspnea because of heart compression, pleural effusion, lung collapse, and pulmonary emboli improved. She died of late complications...
April 1, 2016: A & A Case Reports
Kirsten Eibl-Lindner, Christoph Fürweger, Martin Nentwich, Paul Foerster, Berndt Wowra, Ulrich Schaller, Alexander Muacevic
The aim of the study was to analyze the local efficacy and eye retention rate after frameless, image-guided robotic radiosurgery against uveal melanoma. A total of 217 patients, mostly with medium and large unilateral uveal melanomas (3% small, 62% medium, and 35% large) were treated. The median age was 64 years (range 21-95 years). All patients underwent a single-session procedure beginning with retrobulbar anesthesia, followed by MRI and computerized tomography scanning to generate the treatment plan. The tumor dose was 18-22 Gy (mean, 20...
February 2016: Melanoma Research
Roberta Rotunno, Federica Marenco, Simone Ribero, Stefano Calvieri, Paolo Amerio, Pietro Curatolo, Pietro Quaglino
BACKGROUND: The main purposes of this study were to evaluate the efficacy of electrochemotherapy in head and neck tumors, to assess local tumor control, its safety profile and its impact on the patients' quality of life. METHODS: This is a multicenter prospective, non-randomized phase II trial. This trial was carried out at the Dermatology Clinic of the "Sapienza" University of Rome, at the Dermatology Clinic of the University of Chieti and at the Dermatology Clinic of the University of Turin...
December 2016: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
Kimberly A Thompson, Mark Campbell, Gregory Levens, Dalen Agnew
A 17-yr-old boa constrictor (Boa constrictor constrictor) presented initially with diffuse gingival swelling, loose teeth, and loss of body condition. Examination under anesthesia revealed two firm pink masses within the oral cavity. The largest mass was removed for biopsy. Histopathology and Melan-A-positive immunohistochemistry labeling confirmed a diagnosis of amelanotic melanoma. Secondary stomatitis was treated with antibiotics to improve quality of life, but the snake's condition deteriorated quickly over the next 2 mo...
September 2015: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
Hyder Ridha, Jennifer J Garioch, Eunice K Tan, Martin J Heaton, Laszlo Igali, Marc D Moncrieff
BACKGROUND: Complete excision of high-risk extensive non-melanoma skin cancers in the head and neck is paramount to achieving loco-regional control. However, achieving clear margins still remains a significant challenge. Mohs' micrographic surgery (MMS) provides the most accurate method of intraoperative mapping and histological assessment of tumour margins. We have developed a technique combining MMS with reconstruction as a single-stage procedure performed under general anaesthetic...
December 2015: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
J Jeremić, K Jeremić, A Stefanović, M Gojnić, J Stojnić, Z Nikolić
The estimated incidence of melanoma complicating pregnancy has ranged from 0.1 to 2.8 per 1,000 pregnancies. Here the Authors present a case of a 40-year-old pregnant woman, who was admitted to the Clinic of Obstetrics and Gynaecology in 26 weeks of gestation, with diagnosis of melanoma and suspected with fetal anomaly, as possible bowel obstruction, and polyhydraminos. The melanoma was asported with a wide local excision under local anesthesia. Histological evaluation revealed melanoma Stage Ib (Clark IV, Breslow thickness 1...
2015: Clinical and Experimental Obstetrics & Gynecology
Fahed Zairi, Emilie Le Rhun, Nicolas Bertrand, Thomas Boulanger, Sophie Taillibert, Rabih Aboukais, Richard Assaker, Marc C Chamberlain
Ventricular access devices (VAD) offer several advantages compared to intralumbar injections for the administration of intra-CSF agents in the treatment of leptomeningeal metastases (LM). However, there are few prospective studies reporting on complications with the use of VADs. All complications were prospectively collected that pertained to the implantation and use of a VAD in consecutive patients with solid tumor-related LM from June 2006 to December 2013. Clinical follow-up was every 2 weeks during the initial 2 months of treatment and then once monthly...
September 2015: Journal of Neuro-oncology
Andre A M Torricelli, Gustavo K Marino, Abirami Santhanam, Jiahui Wu, Arun Singh, Steven E Wilson
The epithelial basement membrane (BM) is a specialized extracellular matrix that has been shown to have a critical role in corneal development, wound healing, and disease. Although the epithelial BM contributes to corneal homeostasis, relatively little is know about non-epithelial production of its components that may be important in defective regeneration of the epithelial basement membrane associated with opacity after photorefractive keratectomy. The purpose of the current study was to investigate stromal production of corneal epithelial BM proteins in wounded human corneas using immunohistochemistry...
May 2015: Experimental Eye Research
Chaohui Gu, Fengyan Tian, Zhankui Jia, Guanru Li, Zhenglei Meng, Weizhi Xing, Yafei Ding, Zhibo Jin, Quancheng Kan, Jinjian Yang
OBJECTIVE: The purpose of the study was to evaluate the safety and feasibility of treatment for male circumcision using modified sleeve circumcision and subcuticular suture with the Quill™ device. METHODS: From May 2011 to March 2012, 70 consecutive cases of male circumcision were performed using an alternative technique with the Quill™ device by a single surgeon in our institution. The inclusion and exclusion criteria for the selection process of this procedure were the same as for conventional circumcision...
2015: Urologia Internationalis
Pietro Quaglino, Louise Wichmann Matthiessen, Pietro Curatolo, Tobian Muir, Giulia Bertino, Christian Kunte, Joy Odili, Roberta Rotunno, Alison Claire Humphreys, Valerie Letulé, Federica Marenco, Carol Cuthbert, Rikke Albret, Marco Benazzo, Francesca De Terlizzi, Julie Gehl
BACKGROUND: Electrochemotherapy describes the use of electric pulses to enhance chemotherapy uptake, and has proven highly efficient in treating cutaneous metastases. Patients referred for electrochemotherapy present with diverse clinical pictures, from multiple small lesions to large, ulcerated lesions. Post-electrochemotherapy pain has been observed in some patients. The objectives of this study were to evaluate pain scores before and after electrochemotherapy, and to investigate if patients at risk of post-procedure pain could be identified...
March 2015: Acta Oncologica
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