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https://www.readbyqxmd.com/read/29933461/arrested-hydrocephalus-in-childhood-case-series-and-review-of-the-literature
#1
Yannick Hurni, Andrea Poretti, Jacques Schneider, Raphael Guzman, Gian Paolo Ramelli
INTRODUCTION:  Hydrocephalus can be progressive or spontaneously arrested. In arrested hydrocephalus, the balance between production and absorption of the cerebrospinal fluid is restored. Patients are mostly asymptomatic, and no surgical treatment is necessary for them. METHODS:  We performed a two-center consecutive case series study, aimed at investigating the safety of nonsurgical management of hydrocephalus in selected pediatric patients. We retrospectively selected all consecutive patients, suspected to suffer from arrested hydrocephalus and referred to our two institutions between January 2011 and December 2013...
June 22, 2018: Neuropediatrics
https://www.readbyqxmd.com/read/29933385/testosterone-treatment-and-the-risk-of-aggressive-prostate-cancer-in-men-with-low-testosterone-levels
#2
Thomas J Walsh, Molly M Shores, Chloe A Krakauer, Christopher W Forsberg, Alexandra E Fox, Kathryn P Moore, Anna Korpak, Susan R Heckbert, Steven B Zeliadt, Chloe E Kinsey, Mary Lou Thompson, Nicholas L Smith, Alvin M Matsumoto
PURPOSE: Testosterone treatment of men with low testosterone is common and, although relatively short-term, has raised concern regarding an increased risk of prostate cancer (CaP). We investigated the association between modest-duration testosterone treatment and incident aggressive CaP. MATERIALS AND METHODS: Retrospective inception cohort study of male Veterans aged 40 to 89 years with a laboratory-defined low testosterone measurement from 2002 to 2011 and recent prostate specific antigen (PSA) testing; excluding those with recent testosterone treatment, prostate or breast cancer, high PSA or prior prostate biopsy...
2018: PloS One
https://www.readbyqxmd.com/read/29933364/pharmacokinetics-pharmacodynamics-safety-and-tolerability-of-single-dose-denosumab-in-healthy-chinese-volunteers-a-randomized-single-blind-placebo-controlled-study
#3
Qian Chen, Chaoying Hu, Yanmei Liu, Rong Song, Wenjing Zhu, Hongxin Zhao, Antonio Nino, Fan Zhang, Yun Liu
BACKGROUND: Denosumab is a fully human monoclonal antibody against receptor activator of nuclear factor kappa-B ligand, a cytokine essential for the formation, function and survival of osteoclasts. This study assessed the pharmacokinetics, pharmacodynamics, safety and tolerability of single-dose denosumab (60 and 120 mg) in healthy Chinese volunteers. METHODS: This randomized (3:3:2), single-blind, placebo-controlled study enrolled healthy Chinese volunteers to receive single subcutaneous injection of denosumab 60 mg, 120 mg, or placebo...
2018: PloS One
https://www.readbyqxmd.com/read/29933343/impact-of-a-graded-exercise-program-on-vo2peak-and-survival-in-heart-failure-patients
#4
Johan A Snoek, Thijs M H Eijsvogels, Arnoud W J van 't Hof, Eva Prescott, Maria T Hopman, Evelien Kolkman, Ed P de Kluiver
INTRODUCTION: Although exercise therapy has the potential to improve health outcomes of patients with Chronic Heart Failure (CHF), less than 50% of patients adhere to prescribed physical activity guidelines one year after Cardiac Rehabilitation (CR). We aimed to assess the effects of an extended CR program with 12-months of Graded Exercise Therapy (GET) and resistance exercise training (RT) on exercise capacity and long-term survival in patients with CHF. METHODS: This prospective cohort study included sixty CHF patients between 2009 and 2010...
June 21, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29933314/impact-of-dermoscopy-and-reflectance-confocal-microscopy-on-the-histopathologic-diagnosis-of-lentigo-maligna-lentigo-maligna-melanoma
#5
Ema Mataca, Mario Migaldi, Anna M Cesinaro
BACKGROUND: Equivocal pigmented lesions of the head are usually biopsied to avoid inappropriate treatment. Clinical approach has evolved from simple visual examination to sophisticated techniques for selecting the biopsy sites. OBJECTIVE: This study aimed to retrospectively evaluate the efficiency of dermoscopy (DE) and reflectance confocal microscopy (RCM) in sampling a histopathologically representative focus of lentigo maligna/lentigo maligna melanoma. METHODS: Punch biopsies and surgical excisions of 72 patients, 37 men and 35 women (median age 70...
June 15, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29933309/the-effectiveness-of-the-sport-dragon-boat-racing-in-reducing-the-risk-of-lymphedema-incidence-an-observational-study
#6
Laura Iacorossi, Francesca Gambalunga, Simona Molinaro, Rosaria De Domenico, Diana Giannarelli, Alessandra Fabi
BACKGROUND: Upper extremity lymphedema is a complication that often occurs in women with breast cancer as a result of surgery and/or radiotherapy. Some studies report that a boating activity known as the "dragon boat" sport can benefit these women. AIM: The aim of this study was to assess whether this type of sport prevents or reduces lymphedema, its impact on quality of life (QoL), and the possible predictors of this condition. METHODS: This was an observational study of 2 groups: group A (women who participated in dragon boat racing for at least 6 months) and group B (women who participated in other forms of physical exercise biweekly)...
June 22, 2018: Cancer Nursing
https://www.readbyqxmd.com/read/29933299/preliminary-experience-with-more-stable-polidocanol-foam-in-the-sclerotherapy-of-head-and-neck-venous-malformations
#7
An-Wei Chen, Shao-Hua Liu, Ying-Ying Huang, Tao Wang
BACKGROUND: Foam sclerotherapy is an effective treatment strategy for venous malformations (VMs). Stability is one of the characteristics of sclerosant foams that determine the sclerosing power. OBJECTIVE: To evaluate the clinical outcomes of sclerotherapy with prolonged half-life of hyaluronic acid (HA)-polidocanol (POL) foam for treating head and neck VMs. MATERIALS AND METHODS: Seventy patients with head and neck VMs were enrolled between October 2013 and January 2015 in Qilu Hospital Shandong University...
June 21, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29933272/electroencephalographic-arousal-patterns-under-dexmedetomidine-sedation
#8
Jamie W Sleigh, Susana Vacas, Alana M Flexman, Pekka O Talke
BACKGROUND: The depth of dexmedetomidine-induced sedation is difficult to assess without arousing the patient. We evaluated frontal electroencephalogram (EEG) as an objective measure of dexmedetomidine-induced sedation. Our aims were to characterize the response patterns of EEG during a wide range of dexmedetomidine-induced sedation and to determine which spectral power best correlated with assessed levels of dexmedetomidine-induced sedation. METHODS: Sedline EEG sensor was positioned on the forehead of 16 volunteers...
June 20, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29933267/perioperative-management-in-hepatic-resections-comparative-effectiveness-of-neuraxial-anesthesia-and-disparity-of-care-patterns
#9
Jeron Zerillo, Parul Agarwal, Jashvant Poeran, Nicole Zubizarreta, George Poultsides, Myron Schwartz, Stavros Memtsoudis, Madhu Mazumdar, Samuel DeMaria
BACKGROUND: Complication rates after hepatic resection can be affected by management decisions of the hospital care team and/or disparities in care. This is true in many other surgical populations, but little study has been done regarding patients undergoing hepatectomy. METHODS: Data from the claims-based national Premier Perspective database were used for 2006 to 2014. The analytical sample consisted of adults undergoing partial hepatectomy and total hepatic lobectomy with anesthesia care consisting of general anesthesia (GA) only or neuraxial and GA (n = 9442)...
June 20, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29933251/use-of-communication-tools-for-mechanically-ventilated-patients-in-the-intensive-care-unit
#10
Anna Holm, Pia Dreyer
The use of light and no sedation is gaining currency in the intensive care unit, resulting in more conscious patients. Due to mechanical ventilation, patients are unable to communicate verbally, and may feel frustration. Communication tools may help; however, they are not used systematically in clinical practice. Based on "complex interventions" and a qualitative approach, a communication tool was modified, tested, and evaluated in this study. The tools consisted of a tablet with communication software and a laminated "communication book" with identical structure...
June 22, 2018: Computers, Informatics, Nursing: CIN
https://www.readbyqxmd.com/read/29933207/multi-targeting-effects-of-a-new-synthetic-molecule-jm-20-in-experimental-models-of-cerebral-ischemia
#11
REVIEW
Yanier Nuñez-Figueredo, Jeney Ramírez-Sánchez, Gilberto L Pardo Andreu, Estael Ochoa-Rodríguez, Yamila Verdecia-Reyes, Diogo O Souza
Ischemic stroke is a major cause of death and disability worldwide. Thrombolysis by tissue plasminogen activator is the only pharmacological treatment approved for clinical practice, but has a narrow therapeutic window and poor efficacy when the cell death cascade is activated. Numerous drugs that are thought to protect neurons against injury have previously failed in human trials despite showing efficacy in experimental models of stroke. Herein, we reviewed the main pre-clinical results of the neuroprotective effects of JM-20, a new hybrid molecule, against brain ischemia...
February 12, 2018: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29933206/the-pattern-of-pharmacological-treatment-of-bipolar-patients-discharged-from-psychiatric-units-in-poland
#12
Jan Jaracz, Edyta Tetera- Rudnicka, Magdalena Bierejszyk, Kaja Witczyk, Agnieszka Raczyńska, Wojciech Nowak, Anna Pisarczyk, Krzysztof Woźniak, Wojciech Czernaś, Adam Moniakowski, Krystyna Jaracz
BACKGROUND: The concomitant use of two or more mood stabilisers (MS), second-generation antipsychotics (SGA), lamotrigine as well as antidepressants, is frequently reported in the treatment of bipolar patients The aim of this study was to investigate the pattern of pharmacological treatment with special regard to polypharmacy defined as two or more psychiatric drugs taken at the same time in the same patients with bipolar disorder discharged from psychiatric units in Poland. METHOD: Pharmacotherapy of 127 consecutive patients (57 females and 70 males) with an ICD-10 diagnosis of bipolar disorder (BP) at the point of discharge from five psychiatric regional hospitals/units in Poland, was evaluated in 2015/2016 on the basis of medical files...
February 5, 2018: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29933180/feasibility-and-oncological-safety-of-sentinel-node-biopsy-in-breast-cancer-patients-with-a-local-recurrence
#13
N Biglia, V E Bounous, M Gallo, L Fuso, L G Sgro, F Maggiorotto, R Ponzone
OBJECTIVES: To investigate the role and feasibility of sentinel lymph node biopsy (SLNB) in breast cancer patients with a local recurrence and no clinically positive axillary lymph nodes. MATERIALS AND METHODS: A total of 71 patients underwent SLNB for breast cancer recurrence. At first surgery, they had received SLNB (46.5%), axillary lymph node dissection (ALND) (36.6%) or no axillary surgery (16.9%). RESULTS: Lymphatic migration was successful in 53 out of 71 patients (74...
June 7, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29933106/titania-coating-of-mesoporous-silica-nanoparticles-for-improved-biocompatibility-and-drug-release-within-blood-vessels
#14
Asima Farooq, Ali Shukur, Cai Astley, Lubomira Tosheva, Peter Kelly, Debra Whitehead, May Azzawi
Blood vessel disease is a major contributor to cardiovascular morbidity and mortality and is hallmarked by dysfunction of the lining endothelial cells (ECs). These cells play a significant role in vascular homeostasis, through the release of mediators to control vessel diameter, hence tissue perfusion. Mesoporous silica nanoparticles (MSNs) can be used as potential drug delivery platforms for vasodilator drugs. Here, using an ex vivo model of vascular function, we examine the use of titania coating for improved biocompatibility and release dynamics of MSN loaded sodium nitroprusside (SNP)...
June 19, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29933079/treatment-of-cyclosporine-induced-hypertension-results-from-a-long-term-observational-study-using-different-antihypertensive-medications
#15
Kim Marienhagen, Frank Lehner, Jürgen Klempnauer, Hartmut Hecker, Jürgen Borlak
Post-transplant hypertension (PTH) is a common complication in cyclosporine immunosuppressed patients; however choosing the right antihypertensive medication is challenging. In a long-term observational study (≤13y) we examined different antihypertensive medications on graft/patient survival of kidney recipients with pre-existing and PTH. Altogether thirty-three co-variables were analyzed including dose and type of immunosuppressive and antihypertensive medication, co-medications, serum biochemistries and the glomerular filtration rate (GFR)...
June 19, 2018: Vascular Pharmacology
https://www.readbyqxmd.com/read/29933075/toxicology-study-for-magnetic-injection-of-prednisolone-into-the-rat-cochlea
#16
M Shimoji, B Ramaswamy, M I Shukoor, P Benhal, A Broda, S Kulkarni, P Malik, B McCaffrey, J-F Lafond, A Nacev, I N Weinberg, B Shapiro, D A Depireux
This paper investigates the safety of a novel 'magnetic injection' method of delivering therapy to the cochlea, in a rodent model. In this method of administration, a magnetic field is employed to actively transport drug-eluting iron oxide-core nanoparticles into the cochlea, where they then release their drug payload (we delivered the steroid prednisolone). Our study design and selection of control groups was based on published regulatory guidance for safety studies that involve local drug delivery. We tested for both single and multiple delivery doses to the cochlea, and found that magnetic delivery did not harm hearing...
June 19, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29933055/what-is-the-therapeutic-mechanism-of-pedunculopontine-nucleus-stimulation-in-parkinson-s-disease
#17
REVIEW
Wesley Thevathasan, Elena Moro
Pedunculopontine nucleus (PPN) deep brain stimulation (DBS) is an experimental treatment for in Parkinson's disease (PD) which offers a fairly circumscribed benefit for gait freezing and perhaps balance impairment. The benefit on gait freezing is variable and typically incomplete, which may reflect that the clinical application is yet to be optimised or reflect a fundamental limitation of the therapeutic mechanism. Thus, a better understanding of the therapeutic mechanism of PPN DBS may guide the further development of this therapy...
June 19, 2018: Neurobiology of Disease
https://www.readbyqxmd.com/read/29933054/imaging-correlates-of-behavioral-impairments-an-experimental-pet-study-in-the-rat-pilocarpine-epilepsy-model
#18
Valentina Di Liberto, R Maarten van Dijk, Matthias Brendel, Ann-Marie Waldron, Christina Möller, Ines Koska, Isabel Seiffert, Fabio Gualtieri, Franz Josef Gildehaus, Barbara von Ungern-Sternberg, Magdalena Lindner, Sibylle Ziegler, Rupert Palme, Rainer Hellweg, Peter Gass, Peter Bartenstein, Heidrun Potschka
Psychiatric comorbidities are prevalent in patients with epilepsy and greatly contribute to the overall burden of disease. The availability of reliable biomarkers to diagnose epilepsy-associated comorbidities would allow for effective treatment and improved disease management. Due to their non-invasive nature, molecular imaging techniques such as positron emission tomography (PET) are ideal tools to measure pathologic changes. In the current study we investigated the potential of [18 F]fluoro-2-deoxy-d-glucose ([18 F]FDG) and 2'-methoxyphenyl-(N-2'-pyridinyl)-p-18 F-fluoro-benzamidoethylpiperazine ([18 F]MPPF) as imaging correlates of neurobehavioral comorbidities in the pilocarpine rat model of epilepsy...
June 19, 2018: Neurobiology of Disease
https://www.readbyqxmd.com/read/29933047/pharmacologic-inhibition-of-akt-leads-to-cell-death-in-relapsed-multiple-myeloma
#19
In-Sung Song, Yu Jeong Jeong, Seung Hun Jeong, Hyoung Kyu Kim, Nam-Chul Ha, MyungGeun Shin, Kyung Soo Ko, Byoung Doo Rhee, Sungbo Shim, Sung-Wuk Jang, Jin Han
Multiple myeloma (MM) is a neoplastic plasma cell disorder with high disease recurrence rates. Novel therapeutic approaches capable of improving outcomes in patients with MM are urgently required. The AKT signalling plays a critical regulatory role in MM pathophysiology, including survival, proliferation, metabolism, and has emerged as a key therapeutic target. Here, we identified a novel AKT inhibitor, HS1793, and defined its mechanism of action and clinical significance in MM. HS1793 disrupted the interaction between AKT and heat shock protein 90, resulting in protein phosphatase 2A-modulated phosphorylated-AKT (p-AKT) reduction...
June 19, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29933022/blood-brain-barrier-disruption-dictates-nanoparticle-accumulation-following-experimental-brain-injury
#20
Vimala N Bharadwaj, Rachel K Rowe, Jordan Harrison, Chen Wu, Trent R Anderson, Jonathan Lifshitz, P David Adelson, Vikram D Kodibagkar, Sarah E Stabenfeldt
Clinically, traumatic brain injury (TBI) results in complex heterogeneous pathology that cannot be recapitulated in single pre-clinical animal model. Therefore, we focused on evaluating utility of nanoparticle (NP)-based therapeutics following three diffuse-TBI models: mild-closed-head injury (mCHI), repetitive-mCHI and midline-fluid percussion injury (FPI). We hypothesized that NP accumulation after diffuse TBI correlates directly with blood-brain-barrier permeability. Mice received PEGylated-NP cocktail (20-500nm) (intravenously) after single- or repetitive-(1 impact/day, 5 consecutive days) CHI (immediately) and midline-FPI (1h, 3h and 6h)...
June 19, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
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