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https://www.readbyqxmd.com/read/29786168/variation-in-electrode-redox-potential-selects-for-different-microorganisms-under-cathodic-current-flow-from-electrodes-in-marine-sediments
#1
Bonita R Lam, Annette R Rowe, Kenneth H Nealson
Extracellular electron transport (EET) is a microbial process that allows microorganisms to transport electrons to and from insoluble substrates outside of the cell. Although progress has been made in understanding how microbes transfer electrons to insoluble substrates, the process of receiving electrons has largely remained unexplored. We investigated redox potentials favorable for donating electrons to dissolved and insoluble components in Catalina Harbor marine sediment by combining electrochemical techniques with geochemistry and molecular methods...
May 22, 2018: Environmental Microbiology
https://www.readbyqxmd.com/read/29778558/successful-kidney-transplant-with-eculizumab-thymoglobulin-and-belatacept-therapy-in-a-highly-sensitised-patient-with-atypical-haemolytic-uraemic-syndrome-due-to-factor-h-mutation
#2
John Fredy Nieto-Ríos, Mónica Zuluaga-Quintero, Diana Carolina Bello-Márquez, Arbey Aristizabal-Alzate, Catalina Ocampo-Kohn, Lina María Serna-Higuita, Lina Arias, Gustavo Zuluaga-Valencia
Atypical haemolytic uremic syndrome is a disease caused by complement regulation abnormalities that generally progresses to chronic end-stage renal disease with a high rate of recurrence in kidney transplantation and a high risk of graft loss. Anti-complement therapy has improved the prognosis of these patients, achieving disease remission in most cases, increasing the likelihood of a successful kidney transplant and increasing patient and graft survival. Drugs with low risk of induction of thrombotic microangiopathies such as belatacept and mycophenolate have also been used with satisfactory results...
May 16, 2018: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/29775757/molecular-characterization-of-physis-tissue-by-rna-sequencing
#3
Christopher R Paradise, Catalina Galeano-Garces, Daniela Galeano-Garces, Amel Dudakovic, Todd A Milbrandt, Daniel B F Saris, Aaron J Krych, Marcel Karperien, Gabriel B Ferguson, Denis Evseenko, Scott M Riester, Andre J van Wijnen, A Noelle Larson
The physis is a well-established and anatomically distinct cartilaginous structure that is crucial for normal long-bone development and growth. Abnormalities in physis function are linked to growth plate disorders and other pediatric musculoskeletal diseases. Understanding the molecular pathways operative in the physis may permit development of regenerative therapies to complement surgically-based procedures that are the current standard of care for growth plate disorders. Here, we performed next generation RNA sequencing on mRNA isolated from human physis and other skeletal tissues (e...
May 15, 2018: Gene
https://www.readbyqxmd.com/read/29767736/pollination-of-granadilla-passiflora-ligularis-benefits-from-large-wild-insects
#4
Catalina Gutiérrez-Chacón, Felix Fornoff, Rodulfo Ospina-Torres, Alexandra-Maria Klein
The contribution of wild pollinators to food production has recently been assessed for many crops, although it remains unclear for several tropical crops. Granadilla (Passiflora ligularis Juss), a crop native to the tropical Andes, is one such crop where a gap exists regarding comprehensive knowledge about its pollination system. In a field experiment in the Colombian Andes, we 1) describe flower visitors in terms of visit quantity (visitation rate) and quality (touches of flower-reproductive structures), 2) assess the pollination system by comparing fruit set and fruit weight per flower in three pollination treatments: pollinator exclusion, open pollination, and supplementary pollination, and 3) evaluate pollination deficits (difference between open and supplementary pollination) in relation to pollinator density...
May 15, 2018: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29766554/primary-cutaneous-aspergillosis-at-the-site-of-cyanoacrylate-skin-adhesive-in-a-neonate
#5
Ayan Kusari, Jessica Sprague, Lawrence F Eichenfield, Catalina Matiz, Victoria R Barrio
Primary cutaneous aspergillosis is a rare but potentially life-threatening disease. We present the case of a premature infant who developed primary cutaneous aspergillosis with Aspergillus niger at the site of a skin abrasion that had been treated with a purple-colored cyanoacrylate product. The infection was treated successfully with gentle debridement of the cyanoacrylate product, followed by intravenous voriconazole and topical fluconazole. To our knowledge, this is the first reported case of primary cutaneous aspergillosis occurring at the site of cyanoacrylate-based skin adhesive...
May 15, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29760692/il17-il17ra-as-a-novel-signaling-axis-driving-mesenchymal-stem-cell-therapeutic-function-in-experimental-autoimmune-encephalomyelitis
#6
Mónica Kurte, Patricia Luz-Crawford, Ana María Vega-Letter, Rafael A Contreras, Gautier Tejedor, Roberto Elizondo-Vega, Luna Martinez-Viola, Catalina Fernández-O'Ryan, Fernando E Figueroa, Christian Jorgensen, Farida Djouad, Flavio Carrión
The therapeutic effect of mesenchymal stem cells (MSCs) in multiple sclerosis (MS) and the experimental autoimmune encephalomyelitis (EAE) model has been well described. This effect is, in part, mediated through the inhibition of IL17-producing cells and the generation of regulatory T cells. While proinflammatory cytokines such as IFNγ, TNFα, and IL1β have been shown to enhance MSCs immunosuppressive function, the role of IL17 remains poorly elucidated. The aim of this study was, therefore, to investigate the role of the IL17/IL17R pathway on MSCs immunoregulatory effects focusing on Th17 cell generation in vitro and on Th17-mediated EAE pathogenesis in vivo ...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29753182/personalized-computational-modeling-of-left-atrial-geometry-and-transmural-myofiber-architecture
#7
Thomas E Fastl, Catalina Tobon-Gomez, Andrew Crozier, John Whitaker, Ronak Rajani, Karen P McCarthy, Damian Sanchez-Quintana, Siew Y Ho, Mark D O'Neill, Gernot Plank, Martin J Bishop, Steven A Niederer
Atrial fibrillation (AF) is a supraventricular tachyarrhythmia characterized by complete absence of coordinated atrial contraction and is associated with an increased morbidity and mortality. Personalized computational modeling provides a novel framework for integrating and interpreting the role of atrial electrophysiology (EP) including the underlying anatomy and microstructure in the development and sustenance of AF. Coronary computed tomography angiography data were segmented using a statistics-based approach and the smoothed voxel representations were discretized into high-resolution tetrahedral finite element (FE) meshes...
April 5, 2018: Medical Image Analysis
https://www.readbyqxmd.com/read/29751526/molecular-responses-to-the-zika-virus-in-mosquitoes
#8
REVIEW
Catalina Alfonso-Parra, Frank W Avila
The Zika virus (ZIKV), originally discovered in 1947, did not become a major concern until the virus swept across the Pacific and into the Americas in the last decade, bringing with it news of neurological complications and birth defects in ZIKV affected areas. This prompted researchers to dissect the molecular interactions between ZIKV and the mosquito vector in an attempt to better understand not only the changes that occur upon infection, but to also identify molecules that may potentially enhance or suppress a mosquito’s ability to become infected and/or transmit the virus...
May 3, 2018: Pathogens
https://www.readbyqxmd.com/read/29746871/discrete-typing-units-of-trypanosoma-cruzi-detected-by-real-time-pcr-in-chilean-patients-with-chronic-chagas-cardiomyopathy
#9
Catalina Muñoz-San Martín, Inés Zulantay, Miguel Saavedra, Cristián Fuentealba, Gabriela Muñoz, Werner Apt
Chagas disease is a major public health problem in Latin America and has spread to other countries due to immigration of infected persons. 10-30% of patients with chronic Chagas disease will develop cardiomyopathy. Chagas cardiomyopathy is the worst form of the disease, due to its high morbidity and mortality. Because of its prognostic value and adequate medical monitoring, it is very important to identify infected people who could develop Chagas cardiomyopathy. The aim of this study was to determine if discrete typing units (DTUs) of Trypanosoma cruzi are related to the presence of heart disease in patients with chronic Chagas disease...
May 7, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29746743/-prevalence-and-trends-of-physical-activity-in-children-and-adolescents-results-of-the-ensanut-2012-and-ensanut-mc-2016
#10
Catalina Medina, Alejandra Jáuregui, Ismael Campos-Nonato, Simón Barquera
OBJECTIVE: To describe the prevalence and trends of physical activity (PA) in children and adolescents from Ensanut 2012 and Ensanut MC 2016. MATERIALS AND METHODS: Physical activity levels were obtained from the Health Behaviour in School-aged Children (HBSC) and the International Physical Activity (IPAQ) questionnaires for children and adolescents respectively. RESULTS: More than 80% of the children and 35% of the adolescents in Mexico do not meet the PA recom¬mendations...
May 2018: Salud Pública de México
https://www.readbyqxmd.com/read/29746740/-hypertension-in-mexican-adults-prevalence-diagnosis-and-type-of-treatment-ensanut-mc-2016
#11
Ismael Campos-Nonato, Lucía Hernández-Barrera, Andrea Pedroza-Tobías, Catalina Medina, Simón Barquera
OBJECTIVE: To describe the prevalence, awareness and proportion of adults with an adequate control of hypertension. MATERIALS AND METHODS: Blood pressure was measured at 8 352 adults who participated in the Ensanut MC 2016. The adults who reported having diagnosis of hypertension or had systolic blood pressure values (TAS) ≥140mmHg or diastolic blood pressure (TAD) ≥90mmHg were classified as hypertensive. Hypertension was considered controlled when blood pressure was TAS <140mmHg and TAD <90mmHg...
May 2018: Salud Pública de México
https://www.readbyqxmd.com/read/29742764/ectopic-pancreas-mimicking-gastrointestinal-stromal-tumor-in-the-stomach-fundus
#12
Cătălina Diaconu, Mihai Ciocîrlan, Mariana Jinga, Raluca Simona Costache, Gabriel Constantinescu, Mădălina Ilie, Mircea Diculescu
No abstract text is available yet for this article.
May 9, 2018: Endoscopy
https://www.readbyqxmd.com/read/29740394/metabolic-syndrome-and-antipsychotics-the-role-of-mitochondrial-fission-fusion-imbalance
#13
Andrea Del Campo, Catalina Bustos, Carolina Mascayano, Claudio Acuña-Castillo, Rodrigo Troncoso, Leonel E Rojo
Second-generation antipsychotics (SGAs) are known to increase cardiovascular risk through several physiological mechanisms, including insulin resistance, hepatic steatosis, hyperphagia, and accelerated weight gain. There are limited prophylactic interventions to prevent these side effects of SGAs, in part because the molecular mechanisms underlying SGAs toxicity are not yet completely elucidated. In this perspective article, we introduce an innovative approach to study the metabolic side effects of antipsychotics through the alterations of the mitochondrial dynamics, which leads to an imbalance in mitochondrial fusion/fission ratio and to an inefficient mitochondrial phenotype of muscle cells...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29739318/safety-of-cilostazol-in-peripheral-artery-disease-a-cohort-from-a-primary-healthcare-electronic-database
#14
Jordi Real, M Catalina Serna, Maria Giner-Soriano, Rosa Forés, Guillem Pera, Esther Ribes, Maite Alzamora, Josep Ramon Marsal, Antonio Heras, Rosa Morros
BACKGROUND: Cilostazol has been associated with spontaneous reports of cardiovascular adverse events and serious bleeding. The objective of this study is to determine the relative risk of cardiovascular adverse events or haemorrhages in patients with peripheral artery disease treated with cilostazol in comparison to pentoxifylline users. METHODS: Population-based cohort study including all individuals older than 40 who initiated cilostazol or pentoxifylline during 2009-2011 in SIDIAP database...
May 8, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29734940/correction-to-dialectical-behaviour-therapy-for-treating-adults-and-adolescents-with-emotional-and-behavioural-dysregulation-study-protocol-of-a-coordinated-implementation-in-a-publicly-funded-health-service
#15
Daniel Flynn, Mary Kells, Mary Joyce, Catalina Suarez, Conall Gillespie
Upon publication of the original article (1) it was highlighted by the authors that there was just one error in the manuscript in the 'Sample size' subsection of the Methods/Design.
May 7, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29733965/mesenchymal-stem-cell-s-secretome-promotes-selective-enrichment-of-cancer-stem-like-cells-with-specific-cytogenetic-profile
#16
Gema Jiménez, Michael Hackenberg, Purificación Catalina, Houria Boulaiz, Carmen Griñán-Lisón, María Ángel García, Macarena Perán, Elena López-Ruiz, Alberto Ramírez, Cynthia Morata-Tarifa, Esther Carrasco, Margarita Aguilera, Juan Antonio Marchal
Cancer stem cells (CSCs) are responsible for tumour initiation, metastasis and cancer recurrence, however the involvement of microenvironment is crucial. Here, we have analyzed how human mesenchymal stem cells (MSCs)-derived conditioned medium (CM) affect colon and melanoma CSCs enrichment and maintenance. Our results strongly suggest that the secretome of CM-MSCs selects and maintains subpopulations with high expression of CSCs markers and ALDH1 activity, low proliferation rates with G1 phase arrest, and notably retain in vivo these properties...
May 4, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29727453/the-protein-family-tctasv-c-is-a-novel-trypanosoma-cruzi-virulence-factor-secreted-in-extracellular-vesicles-by-trypomastigotes-and-highly-expressed-in-bloodstream-forms
#17
Lucas D Caeiro, Catalina D Alba-Soto, Mariana Rizzi, María Elisa Solana, Giselle Rodriguez, Agustina M Chidichimo, Matías E Rodriguez, Daniel O Sánchez, Gabriela V Levy, Valeria Tekiel
TcTASV-C is a protein family of about 15 members that is expressed only in the trypomastigote stage of Trypanosoma cruzi. We have previously shown that TcTASV-C is located at the parasite surface and secreted to the medium. Here we report that the expression of different TcTASV-C genes occurs simultaneously at the trypomastigote stage and while some secreted and parasite-associated products are found in both fractions, others are different. Secreted TcTASV-C are mainly shedded through trypomastigote extracellular vesicles, of which they are an abundant constituent, despite its scarce expression on culture-derived trypomastigotes...
May 4, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29724029/somatotropic-axis-dysfunction-in-non-alcoholic-fatty-liver-disease-beneficial-hepatic-and-systemic-effects-of-hormone-supplementation
#18
Daniel Cabrera, Claudio Cabello-Verrugio, Nancy Solís, Diego San Martín, Catalina Cofré, Margarita Pizarro, Juan Pablo Arab, Johanna Abrigo, Fabián Campos, Betzabé Irigoyen, Gonzalo Carrasco-Avino, Katiuska Bezares, Valentina Riquelme, Arnoldo Riquelme, Marco Arrese, Francisco Barrera
BACKGROUND: Somatotropic axis dysfunction associated with non-alcoholic fatty liver disease (NAFLD) has potential multisystemic detrimental effects. Here, we analysed the effects of growth hormone (GH) and insulin -like growth factor-1 (IGF-1) supplementation on liver histology, adipokine profile and muscle function in an NAFLD model. METHODS: C57BL/6 mice were fed with a high fat diet (HFD) for 12 weeks and were separated into three groups treated for 4 weeks with: (1) High fat diet (HFD) ( n = 10); (2) HFD + GH 9 &mu;g/g/d ( n = 10); (3) HFD + IGF-1 0...
May 2, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29723075/orlistat-as-a-fasn-inhibitor-and-multitargeted-agent-for-cancer-therapy
#19
Alejandro Schcolnik-Cabrera, Alma Chávez-Blanco, Guadalupe Domínguez-Gómez, Lucia Taja-Chayeb, Rocio Cardenas-Barcenas, Catalina Trejo-Becerril, Enrique Perez-Cardenas, Aurora Gonzalez-Fierro, Alfonso Dueñas-González
Cancer cells have increased glycolysis and glutaminolysis. Their third feature is increased de novo lipogenesis. As such, fatty acid (FA) synthesis enzymes are over-expressed in cancer and their depletion causes antitumor effects. As fatty acid synthase (FASN) plays a pivotal role in this process, it is an attractive target for cancer therapy. Areas covered: This is a review of the lipogenic phenotype of cancer and how this phenomenon can be exploited for cancer therapy using inhibitors of FASN, with particular emphasis on orlistat as a repurposing drug...
May 3, 2018: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/29720357/a-mental-health-storytelling-intervention-using-transmedia-to-engage-latinas-grounded-theory-analysis-of-participants-perceptions-of-the-story-s-main-character
#20
MarySue V Heilemann, Adrienne Martinez, Patricia D Soderlund
BACKGROUND: Transmedia storytelling was used to attract English-speaking Latina women with elevated symptoms of depression and anxiety to engage in an intervention that included videos and a webpage with links to symptom management resources. However, a main character for the storyline who was considered dynamic, compelling, and relatable by the target group was needed. OBJECTIVE: We conducted interviews with 28 English-speaking Latinas (target group) with elevated symptoms of depression or anxiety who participated in an Internet-accessible transmedia storytelling intervention...
May 2, 2018: Journal of Medical Internet Research
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