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https://www.readbyqxmd.com/read/28527265/-profile-of-lithium-carbonate-use-in-patients-with-bipolar-disorder-in-colombia
#1
Manuel Enrique Machado-Duque, Catalina Alzate-Carvajal, Kevin Zapata-Castañeda, Jorge Enrique Machado-Alba
INTRODUCTION: Lithium is the drug of choice for the treatment of bipolar affective disorder. OBJECTIVE: To define lithium therapeutic profile and adverse reactions to its use in patients with bipolar affective disorder in Colombia. MATERIALS AND METHODS: We conducted an observational retrospective cohort study between January 1 and December 31, 2013, which included patients with a diagnosis of bipolar disorder treated with lithium carbonate in 25 Colombian cities; we evaluated socio-demographic variables, lithium dose, co-medication, drug interactions and adverse reactions...
April 1, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/28526725/phylogeography-and-genetic-structure-of-endemic-acmispon-argophyllus-and-a-dendroideus-fabaceae-across-the-california-channel-islands
#2
Lisa E Wallace, Gregory L Wheeler, Mitchell E McGlaughlin, Gerald Bresowar, Kaius Helenurm
PREMISE OF THE STUDY: Taxa inhabiting the California Channel Islands exhibit variation in their degree of isolation, but few studies have considered patterns across the entire archipelago. We studied phylogeography of insular Acmispon argophyllus and A. dendroideus to determine whether infraspecific taxa are genetically divergent and to elucidate patterns of diversification across these islands. METHODS: DNA sequences were collected from nuclear (ADH) and plastid genomes (rpL16, ndhA, psbD-trnT) from >450 samples on the Channel Islands and California...
May 19, 2017: American Journal of Botany
https://www.readbyqxmd.com/read/28523864/allergic-contact-dermatitis-due-to-methylisothiazolinone-in-a-young-girl-s-laundry-detergent
#3
Colleen H Cotton, Cliff G Duah, Catalina Matiz
Methylisothiazolinone (MI) is an emerging and increasing cause of allergic contact dermatitis (ACD) in children. We present the case of a 7-year-old girl with an unusual dermatitis suspicious for contact allergy. Patch testing confirmed allergy to MI, found only in the patient's laundry detergent. This case highlights the importance of checking household product ingredients and the role of MI as an increasing cause of ACD in children.
May 19, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28523324/anatomical-features-and-prosthetic-considerations-of-edentulous-patients-with-mandibular-reconstruction-with-autograft-performed-more-than-40-years-ago
#4
Cătălina Murariu-Măgureanu, Cristina Teodora Preoteasa, Laura Iosif, Marina Imre, Marian Cuculescu, Elena Preoteasa
In this manuscript there are presented two cases, both with mandibular reconstruction with autograft harvested from the iliac crest, performed more than 40 years ago, but with different bone defect etiology, i.e., mandibular dysplasia and mandibular fracture, both having currently extensive tooth loss in the mandible, being in need for prosthetic rehabilitation. These cases confirm that reconstructive surgery of mandibular bone defects with autograft from iliac crest has a satisfactory long-term outcome, providing acceptable conditions for prosthetic rehabilitation...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28518147/survivin-a-key-player-in-cancer-progression-increases-in-obesity-and-protects-adipose-tissue-stem-cells-from-apoptosis
#5
Miriam Ejarque, Victòria Ceperuelo-Mallafré, Carolina Serena, Gisela Pachón, Yaiza Núñez-Álvarez, Margarida Terrón-Puig, Enrique Calvo, Catalina Núñez-Roa, Wilfredo Oliva-Olivera, Francisco J Tinahones, Miguel Angel Peinado, Joan Vendrell, Sonia Fernández-Veledo
Adipose tissue (AT) has a central role in obesity-related metabolic imbalance through the dysregulated production of cytokines and adipokines. In addition to its known risk for cardiovascular disease and diabetes, obesity is also a major risk for cancer. We investigated the impact of obesity for the expression of survivin, an antiapoptotic protein upregulated by adipokines and a diagnostic biomarker of tumor onset and recurrence. In a cross-sectional study of 111 subjects classified by body mass index, circulating levels of survivin and gene expression in subcutaneous AT were significantly higher in obese patients and positively correlated with leptin...
May 18, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28513599/corrigendum-arctic-megaslide-at-presumed-rest
#6
Wolfram H Geissler, A Catalina Gebhardt, Felix Gross, Jutta Wollenburg, Laura Jensen, Mechita C Schmidt-Aursch, Sebastian Krastel, Judith Elger, Giacomo Osti
No abstract text is available yet for this article.
May 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28508775/semantic-technologies-for-re-use-of-clinical-routine-data
#7
Markus Kreuzthaler, Catalina Martínez-Costa, Peter Kaiser, Stefan Schulz
Routine patient data in electronic patient records are only partly structured, and an even smaller segment is coded, mainly for administrative purposes. Large parts are only available as free text. Transforming this content into a structured and semantically explicit form is a prerequisite for querying and information extraction. The core of the system architecture presented in this paper is based on SAP HANA in-memory database technology using the SAP Connected Health platform for data integration as well as for clinical data warehousing...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28508599/image-and-related-undergrowth-syndromes-the-complex-spectrum-of-gain-of-function-cdkn1c-mutations
#8
Catalina Cabrera-Salcedo, Priya Kumar, Vivian Hwa, Andrew Dauber
CDKN1C is a cyclin-dependent kinase Inhibitor and negative regulator of cellular proliferation. Recently, gain-of-function mutations in the PCNA domain of CDKN1C have been reported as the genetic basis of various growth-retarded syndromes including IMAGe syndrome, Russell Silver syndrome as well as a novel undergrowth syndrome that additionally exhibited early adulthood onset diabetes. This review summarizes the key clinical features and the molecular advances that have contributed to our understanding of this complex phenotypic spectrum...
March 2017: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28506861/do-urinary-leakage-circumstances-in-women-with-urinary-incontinence-correlate-with-physician-diagnosis-and-urodynamic-results-a-questionnaire-validation-study
#9
Krystel Nyangoh Timoh, Arnaud Fauconnier, Marion Ravit, Georges Bader, Catalina Varas Ramos, Xavier Fritel
OBJECTIVES: To investigate if leakage circumstances collected using the Urinary Leakage Circumstances Questionnaire (ULCQ) are correlated with physician diagnosis and urodynamic results and resolve after surgery. METHODS: The ULCQ was developed to investigate leakage circumstances encountered by incontinent women. Women completed both the ULCQ and the International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form (ICIQ-UI SF) before clinical and urodynamic exam...
May 12, 2017: Urology
https://www.readbyqxmd.com/read/28504683/normalizing-single-cell-rna-sequencing-data-challenges-and-opportunities
#10
Catalina A Vallejos, Davide Risso, Antonio Scialdone, Sandrine Dudoit, John C Marioni
Single-cell transcriptomics is becoming an important component of the molecular biologist's toolkit. A critical step when analyzing data generated using this technology is normalization. However, normalization is typically performed using methods developed for bulk RNA sequencing or even microarray data, and the suitability of these methods for single-cell transcriptomics has not been assessed. We here discuss commonly used normalization approaches and illustrate how these can produce misleading results. Finally, we present alternative approaches and provide recommendations for single-cell RNA sequencing users...
May 15, 2017: Nature Methods
https://www.readbyqxmd.com/read/28487760/isoxazole-derivatives-as-new-nitric-oxide-elicitors-in-plants
#11
Anca Oancea, Emilian Georgescu, Florentina Georgescu, Alina Nicolescu, Elena Iulia Oprita, Catalina Tudora, Lucian Vladulescu, Marius-Constantin Vladulescu, Florin Oancea, Calin Deleanu
Several 3,5-disubstituted isoxazoles were obtained in good yields by regiospecific 1,3-dipolar cycloaddition reactions between aromatic nitrile oxides, generated in situ from the corresponding hydroxyimidoyl chlorides, with non-symmetrical activated alkynes in the presence of catalytic amounts of copper(I) iodide. Effects of 3,5-disubstituted isoxazoles on nitric oxide and reactive oxygen species generation in Arabidopsis tissues was studied using specific diaminofluoresceine dyes as fluorescence indicators...
2017: Beilstein Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28483921/lack-of-liver-glycogen-causes-hepatic-insulin-resistance-and-steatosis-in-mice
#12
Jose M Irimia, Catalina M Meyer, Dyann M Segvich, Sneha Surendran, Anna A DePaoli-Roach, Nuria Morral, Peter J Roach
Disruption of the Gys2 gene that encodes the liver isoform of glycogen synthase generates a mouse (LGSKO mouse) with an almost complete lack of hepatic glycogen, impaired glucose disposal and a pre-disposition to enter the fasted state. This study explores how the lack of liver glycogen increases fat accumulation and the development of liver insulin resistance. Insulin signaling in LGSKO mice is reduced in liver, but not in muscle, suggesting an organ specific defect. Phosphorylation of several components of the hepatic insulin signaling pathway, IRS1, Akt, and GSK3, were decreased in LGSKO mice and, after insulin stimulation, their responses were significantly suppressed, both temporally and in an insulin dose response...
May 8, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28483171/-a-38-year-old-woman-with-a-legal-and-voluntary-interruption-of-pregnancy-due-to-mental-health-risk-an-unexpected-outcome
#13
Diana Restrepo, Marle Duque, Laura Montoya, Catalina Hoyos
OBJECTIVE: To describe a case of legal and voluntary interruption of pregnancy due to a mental health risk in the mother. However, the foetus survived and the mother decided to care for the child. METHODS: Description of the case and a non-systematic review of the relevant literature. RESULTS: A multiparous woman of 38 years with unknown gestational age who requests legal and voluntary interruption of pregnancy. After abortion a male child born of 1050 grams was born, intubated and admitted to intensive care...
April 2017: Revista Colombiana de Psiquiatría
https://www.readbyqxmd.com/read/28476327/associations-between-neighborhood-characteristics-and-sexual-risk-behaviors-among-hiv-infected-and-hiv-uninfected-women-in-the-southern-united-states
#14
Danielle F Haley, Regine Haardörfer, Michael R Kramer, Adaora A Adimora, Gina M Wingood, Neela D Goswami, Anna Rubtsova, Christina Ludema, DeMarc A Hickson, Catalina Ramirez, Zev Ross, Hector Bolivar, Hannah L F Cooper
PURPOSE: Neighborhood characteristics shape sexual risk in HIV-uninfected adults in the United States (US). We assess relationships between census tract characteristics and sexual risk behaviors in a predominantly HIV-infected cohort of women living in the Southern US. METHODS: This cross-sectional multilevel analysis included data from 737 HIV-infected and HIV-uninfected women enrolled in the Women's Interagency HIV Study. Administrative data captured characteristics of census tracts where women lived; participant-level data were gathered via survey...
April 2017: Annals of Epidemiology
https://www.readbyqxmd.com/read/28476126/key-aspects-related-to-implementation-of-risk-stratification-in-health-care-systems-the-assehs-study
#15
Joana Mora, Miren David Iturralde, Lucía Prieto, Cristina Domingo, Marie-Pierre Gagnon, Catalina Martínez-Carazo, Anna Giné March, Daniele De Massari, Tino Martí, Marco Nalin, Francesca Avolio, Jean Bousquet, Esteban de Manuel Keenoy
BACKGROUND: The lack of proven efficacy of new healthcare interventions represents a problem for health systems globally. It is partly related to suboptimal implementation processes, leading to poor adoption of new interventions. Activation of Stratification Strategies and Results of the interventions on frail patients of Healthcare Services (ASSEHS) EU project (N° 2013 12 04) aims to study current existing health Risk Stratification (RS) strategies and tools on frail elderly patients...
May 5, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28473253/g-protein-coupled-receptor-kinases-grks-in-tumorigenesis-and-cancer-progression-gpcr-regulators-and-signaling-hubs
#16
REVIEW
Laura Nogués, Julia Palacios-García, Clara Reglero, Verónica Rivas, María Neves, Catalina Ribas, Petronila Penela, Federico Mayor
Increasing evidences point to G protein-coupled receptor kinases (GRKs), a subfamily of protein kinase A/G/C-like kinases, as relevant players in cancer progression, in a cell-type and tumor-specific way. Alterations in the expression and/or activity of particular GRKs have been identified in several types of tumors, and demonstrated to modulate the proliferation, survival or invasive properties of tumor cells by acting as integrating signaling nodes. GRKs are able to regulate the functionality of both G protein-coupled receptors (GPCR) and growth factor receptors and to directly control cytosolic, cytoskeletal or nuclear signaling components of pathways relevant for these processes...
May 1, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28472919/webgivi-a-web-based-gene-enrichment-analysis-and-visualization-tool
#17
Liang Sun, Yongnan Zhu, A S M Ashique Mahmood, Catalina O Tudor, Jia Ren, K Vijay-Shanker, Jian Chen, Carl J Schmidt
BACKGROUND: A major challenge of high throughput transcriptome studies is presenting the data to researchers in an interpretable format. In many cases, the outputs of such studies are gene lists which are then examined for enriched biological concepts. One approach to help the researcher interpret large gene datasets is to associate genes and informative terms (iTerm) that are obtained from the biomedical literature using the eGIFT text-mining system. However, examining large lists of iTerm and gene pairs is a daunting task...
May 4, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28460112/baseline-in-vivo-ex-vivo-and-molecular-responses-of-plasmodium-falciparum-to-artemether-and-lumefantrine-in-three-endemic-zones-for-malaria-in-colombia
#18
Samanda Aponte, Ángela Patricia Guerra, Catalina Álvarez-Larrotta, Sindy Durley Bernal, César Restrepo, Camila González, María Fernanda Yasnot, Angélica Knudson-Ospina
Background: Colombia began using artemisinin-based combination therapies for the treatment of uncomplicated Plasmodium falciparum malaria in 2006. It is necessary to implement resistance surveillance to antimalarial drugs in order to promptly detect changes in parasite susceptibility. The aim of this study was to establish a susceptibility baseline of P. falciparum to artemether-lumefantrine using three monitoring tools. Methods: Patients with uncomplicated malaria treated with artemether-lumefantrine underwent clinical and parasitological follow-up over 28 days...
February 1, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28454342/feasibility-and-antitumor-efficacy-in-vivo-of-simultaneously-targeting-glycolysis-glutaminolysis-and-fatty-acid-synthesis-using-lonidamine-6-diazo-5-oxo-l-norleucine-and-orlistat-in-colon-cancer
#19
Diana Cervantes-Madrid, Guadalupe Dominguez-Gomez, Aurora Gonzalez-Fierro, Enrique Perez-Cardenas, Lucia Taja-Chayeb, Catalina Trejo-Becerril, Alfonso Duenas-Gonzalez
The aim of the present study was to investigate in vivo the feasibility and efficacy of the combination of lonidamine (LND), 6-diazo-5-oxo-L-norleucine (DON) and orlistat to simultaneously target glycolysis, glutaminolysis and de novo synthesis of fatty acids, respectively. The doses of LND and DON used in humans were translated to mouse doses (77.7 mg/kg and 145.5 mg/kg, respectively) and orlistat was used at 240 mg/kg. Three schedules of LND, DON and orlistat at different doses were administered by intraperitoneal injection to BALB/c mice in a 21-day cycle (schedule 1: LND, 0...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28453222/noncontingent-reinforcement-competes-with-response-performance
#20
Michael E Kelley, Cy B Nadler, Catalina Rey, Sarah Cowie, Christopher A Podlesnik
Noncontingent reinforcement is a commonly used procedure to decrease levels of problem behavior. Goals of this intervention are to decrease motivation, responding, and the functional relation between behavior and consequences, but it could also possibly compete with performance of alternative desirable responses. In the current study, we assessed the effects of noncontingent reinforcement arranged from 0% to 100% of sessions on performance of alternative responding across two experiments. Experiment 1 assessed manding (i...
April 28, 2017: Journal of the Experimental Analysis of Behavior
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