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Zoraida Verde, Jose M Rodríguez González-Moro, Luis M Chicharro, Luis Reinoso-Barbero, Fernando Bandrés, Félix Gómez-Gallego, Catalina Santiago
Reports regarding smoking differences in α-klotho expression have provided conflicting results. In the current study we focused on the influence of smoking intensity to serum levels of the aging molecule α-klotho in healthy smokers. 40 middle aged healthy smokers without airway obstruction or restriction were selected for the analysis. Serum levels of soluble α-klotho were significantly higher in heavy smokers (P < 0.001). These results are in agreement with the possibility that α-klotho acts as anti-inflammatory molecule and strengthen the hypothesis that an increase of serum levels of α-klotho might be a compensatory response to smoking stress in healthy population...
October 17, 2016: Lung
Matthew D Sacchet, M Catalina Camacho, Emily E Livermore, Ewart A C Thomas, Ian H Gotlib
BACKGROUND: Growing evidence indicates that major depressive disorder (MDD) is characterized by accelerated biological aging, including greater age-related changes in physiological functioning. The disorder is also associated with abnormal neural reward circuitry, particularly in the basal ganglia (BG). Here we assessed age-related changes in BG volume in both patients with MDD and healthy control participants. METHODS: We obtained whole-brain T1-weighted images from patients with MDD and healthy controls...
January 1, 2017: Journal of Psychiatry & Neuroscience: JPN
Catalina E Kopetz, Anahi Collado, Carl W Lejuez
The current research explores the idea that self-defeating behaviors represent means toward individuals' goals. In this quality, they may be automatically initiated upon goal activation without individual's voluntary intention and thus exemplify the long-held idea that the end justifies the means. To investigate this notion empirically we explored one of the most problematic self-defeating behavior: engagement in sex exchange for crack cocaine. This behavior is common among female drug users despite its well-known health and legal consequences...
December 2015: Motivation Science
Emilio Yángüez, Alicia García-Culebras, Aldo Frau, Catalina Llompart, Klaus-Peter Knobeloch, Sylvia Gutierrez-Erlandsson, Adolfo García-Sastre, Mariano Esteban, Amelia Nieto, Susana Guerra
[This corrects the article DOI: 10.1371/journal.ppat.1003632.].
October 2016: PLoS Pathogens
Berta Gallego, Soledad Martos, Catalina Cabot, Juan Barceló, Charlotte Poschenrieder
The hypothesis of metal defense as a substitute for a defective biotic stress signaling system in metal hyperaccumulators was tested using the pathosystem Alternaria brassicicola - Noccaea caerulescens under low (2 μM), medium (12 μM), and high (102 μM) Zn supply. Regardless the Zn supply, N. caerulescens responded to fungal attack with the activation of both HMA4 coding for a Zn transporter, and biotic stress signaling pathways. Salicylate, jasmonate, abscisic acid, and indoleacetic acid concentrations, as well as biotic stress marker genes (PDF1...
October 13, 2016: Physiologia Plantarum
Ana María Vega-Letter, Mónica Kurte, Catalina Fernández-O'Ryan, Melanie Gauthier-Abeliuk, Patricia Fuenzalida, Ivón Moya-Uribe, Claudia Altamirano, Fernando Figueroa, Carlos Irarrázabal, Flavio Carrión
BACKGROUND: Recently, it has been observed that mesenchymal stem cells (MSCs) can modulate their immunoregulatory properties depending on the specific in-vitro activation of different Toll-like receptors (TLR), such as TLR3 and TLR4. In the present study, we evaluated the effect of polyinosinic:polycytidylic acid (poly(I:C)) and lipopolysaccharide (LPS) pretreatment on the immunological capacity of MSCs in vitro and in vivo. METHODS: C57BL/6 bone marrow-derived MSCs were pretreated with poly(I:C) and LPS for 1 hour and their immunomodulatory capacity was evaluated...
October 10, 2016: Stem Cell Research & Therapy
Carolina Gómez-Gaete, Macarena Retamal, Catalina Chávez, Paulina Bustos, Ricardo Godoy, Pablo Torres-Vergara
Rhein is an active metabolite of the drug diacerein, whose anti-inflammatory properties have been demonstrated in both in vitro and in vivo models. However, the low oral bioavailability of rhein has limited its utility as a potential treatment of osteoarthritis (OA), a chronic inflammatory disease. In order to overcome this limitation, the aim of this work was the development of a drug delivery system intended for intra-articular administration of rhein, based on polymeric biodegradable PLGA microparticles (MPs) loaded with the drug...
October 6, 2016: European Journal of Pharmaceutical Sciences
Héctor Gómez-Dantés, Nancy Fullman, Héctor Lamadrid-Figueroa, Lucero Cahuana-Hurtado, Blair Darney, Leticia Avila-Burgos, Ricardo Correa-Rotter, Juan A Rivera, Simon Barquera, Eduardo González-Pier, Tania Aburto-Soto, Elga Filipa Amorin de Castro, Tonatiuh Barrientos-Gutiérrez, Ana C Basto-Abreu, Carolina Batis, Guilherme Borges, Ismael Campos-Nonato, Julio C Campuzano-Rincón, Alejandra de Jesús Cantoral-Preciado, Alejandra G Contreras-Manzano, Lucia Cuevas-Nasu, Vanessa V de la Cruz-Gongora, Jose L Diaz-Ortega, María de Lourdes García-García, Armando Garcia-Guerra, Teresita González de Cossío, Luz D González-Castell, Ileana Heredia-Pi, Marta C Hijar-Medina, Alejandra Jauregui, Aida Jimenez-Corona, Nancy Lopez-Olmedo, Carlos Magis-Rodríguez, Catalina Medina-Garcia, Maria E Medina-Mora, Fabiola Mejia-Rodriguez, Julio C Montañez, Pablo Montero, Alejandra Montoya, Grea L Moreno-Banda, Andrea Pedroza-Tobías, Rogelio Pérez-Padilla, Amado D Quezada, Vesta L Richardson-López-Collada, Horacio Riojas-Rodríguez, Maria J Ríos Blancas, Christian Razo-Garcia, Martha P Romero Mendoza, Tania G Sánchez-Pimienta, Luz M Sánchez-Romero, Astrid Schilmann, Edson Servan-Mori, Teresa Shamah-Levy, Martha M Téllez-Rojo, José L Texcalac-Sangrador, Haidong Wang, Theo Vos, Mohammad H Forouzanfar, Mohsen Naghavi, Alan D Lopez, Christopher J L Murray, Rafael Lozano
BACKGROUND: Child and maternal health outcomes have notably improved in Mexico since 1990, whereas rising adult mortality rates defy traditional epidemiological transition models in which decreased death rates occur across all ages. These trends suggest Mexico is experiencing a more complex, dissonant health transition than historically observed. Enduring inequalities between states further emphasise the need for more detailed health assessments over time. The Global Burden of Diseases, Injuries, and Risk Factors Study 2013 (GBD 2013) provides the comprehensive, comparable framework through which such national and subnational analyses can occur...
October 5, 2016: Lancet
Karina Banda-R, Alfonso Delgado-Salinas, Kyle G Dexter, Reynaldo Linares-Palomino, Ary Oliveira-Filho, Darién Prado, Martin Pullan, Catalina Quintana, Ricarda Riina, Gina M Rodríguez M, Julia Weintritt, Pedro Acevedo-Rodríguez, Juan Adarve, Esteban Álvarez, Anairamiz Aranguren B, Julián Camilo Arteaga, Gerardo Aymard, Alejandro Castaño, Natalia Ceballos-Mago, Álvaro Cogollo, Hermes Cuadros, Freddy Delgado, Wilson Devia, Hilda Dueñas, Laurie Fajardo, Ángel Fernández, Miller Ángel Fernández, Janet Franklin, Ethan H Freid, Luciano A Galetti, Reina Gonto, Roy González-M, Roger Graveson, Eileen H Helmer, Álvaro Idárraga, René López, Humfredo Marcano-Vega, Olga G Martínez, Hernán M Maturo, Morag McDonald, Kurt McLaren, Omar Melo, Francisco Mijares, Virginia Mogni, Diego Molina, Natalia Del Pilar Moreno, Jafet M Nassar, Danilo M Neves, Luis J Oakley, Michael Oatham, Alma Rosa Olvera-Luna, Flávia F Pezzini, Orlando Joel Reyes Dominguez, María Elvira Ríos, Orlando Rivera, Nelly Rodríguez, Alicia Rojas, Tiina Särkinen, Roberto Sánchez, Melvin Smith, Carlos Vargas, Boris Villanueva, R Toby Pennington
Seasonally dry tropical forests are distributed across Latin America and the Caribbean and are highly threatened, with less than 10% of their original extent remaining in many countries. Using 835 inventories covering 4660 species of woody plants, we show marked floristic turnover among inventories and regions, which may be higher than in other neotropical biomes, such as savanna. Such high floristic turnover indicates that numerous conservation areas across many countries will be needed to protect the full diversity of tropical dry forests...
September 23, 2016: Science
Tolunay Beker Aydemir, Catalina Troche, Min-Hyun Kim, Robert J Cousins
Zinc influences signaling pathways through controlled targeted zinc transport. Zinc transporter Zip14 KO mice display a phenotype which includes impaired intestinal barrier function with low-grade chronic inflammation, hyperinsulinemia and increased body fat which are signatures of diet-induced diabetes (type 2 diabetes) and obesity in humans. Hyperglycemia in type 2 diabetes and obesity is caused by insulin resistance. Insulin resistance results in inhibition of glucose uptake by liver and other peripheral tissues, principally adipose and muscle and with concurrently higher hepatic glucose production...
October 4, 2016: Journal of Biological Chemistry
Juliana Velosa-Porras, Francina Escobar-Arregoces, Catalina Latorre-Uriza, María B Ferro-Camargo, Álvaro J Ruiz, Luis F Uriza-Carrasco
Over the past two decades, there has been increasing interest in the impact of oral health on cardiovascular disease, particularly regarding the effects of chronic infections such as periodontitis on the endothelium. The aim of this study was to evaluate in healthy smokers whether there are any significant differences in the frequency of endothelial dysfunction between subjects with chronic moderate to severe periodontal disease and periodontally healthy subjects. An observational cross-sectional study was conducted...
April 2016: Acta Odontológica Latinoamericana: AOL
Elizabeth Moses, Teresa Wang, Sean Corbett, George R Jackson, Eduard Drizik, Catalina Perdomo, Claudia Perdomo, Eric Kleerup, Daniel Brooks, George O'Connor, Steven Dubinett, Patrick Hayden, Marc E Lenburg, Avrum Spira
Little evidence is available regarding the physiological effects of exposure to electronic cigarette (ECIG) aerosol. We sought to determine the molecular impact of ECIG aerosol exposure in human bronchial epithelial cells. Gene expression profiling was conducted in primary human bronchial epithelial cells (HBECs) grown at Air Liquid Interface and exposed to one of four different ECIG aerosols, traditional cigarette (TCIG) smoke, or clean air. Findings were validated experimentally with qPCR and a reactive oxygen species immunoassay...
October 3, 2016: Toxicological Sciences: An Official Journal of the Society of Toxicology
Catalina Ana Rosselló, Lisa Lindström, Johan Glindre, Greta Eklund, Maria Alvarado-Kristensson
The cytosolic role of γ-tubulin as a microtubule organizer has been studied thoroughly, but its nuclear function is poorly understood. Here, we show that γ-tubulin is located throughout the chromatin of demembranated Xenopus laevis sperm and, as the nucleus is formed, γ-tubulin recruits lamin B3 and nuclear membranes. Immunodepletion of γ-tubulin impairs X. laevis assembly of both the lamina and the nuclear membrane. During nuclear formation in mammalian cell lines, γ-tubulin establishes a cellular protein boundary around chromatin that coordinates nuclear assembly of the daughter nuclei...
September 2016: Heliyon
Jinoos Yazdany, Nick Bansback, Megan Clowse, Deborah Collier, Karen Law, Katherine P Liao, Kaleb Michaud, Esi M Morgan, James C Oates, Catalina Orozco, Andreas Reimold, Julia F Simard, Rachel Myslinski, Salahuddin Kazi
BACKGROUND: The Rheumatology Informatics System for Effectiveness (RISE) is a national electronic medical record (EMR)-enabled registry. RISE passively collects data from EMRs of participating practices, provides advanced quality measurement and data analytic capacities, and fulfills national quality reporting requirements. Here we report the registry's architecture and initial data, and demonstrate how RISE is being used to improve the quality of care. METHODS: RISE is a certified Centers for Medicare and Medicaid Services Qualified Clinical Data Registry, allowing collection of data without individual patient informed consent...
October 1, 2016: Arthritis Care & Research
Nerea Maiz, Ignacio Alonso, María Belar, Jorge Burgos, Ana Irasarri, Francisca S Molina, Catalina De Paco, José I Pijoan, Walter Plasencia, Carlota Rodó, M Angeles Rodríguez, Mauricio Tajada, Albert Tubau
OBJECTIVE: to evaluate the acquisition-related factors influencing the quality of the brain volumes for further study of advanced neurosonography. METHODS: This was a prospective multicentre study. Five centres were asked to include five cases each, acquiring two volumes per case, at different gestational ages. Ten operators performed an advanced neurosonography per case. The potential influence of the following factors on the number of evaluable structures was assessed: vaginal/ abdominal acquisition, position of the head, gestational age, subjective quality of the volume, and the acquiring operator itself...
October 1, 2016: Prenatal Diagnosis
Hugo Sepulveda, Rodrigo Aguilar, Catalina P Prieto, Francisco Bustos, Sócrates Aedo, José Lattus, Brigitte van Zundert, Veronica Palma, Martin Montecino
Wharton's Jelly mesenchymal stem cells (WJ-MSCs) are an attractive potential source of multipotent stem cells for bone tissue replacement therapies. However, the molecular mechanisms involved in their osteogenic conversion are poorly understood. Particularly, epigenetic control operating at the promoter regions of the two master regulators of the osteogenic program, RUNX2/P57 and SP7 has not yet been described in WJ-MSCs. Via quantitative PCR profiling and chromatin immunoprecipitation (ChIP) studies here we analyze the ability of WJ-MSCs to engage osteoblast lineage...
September 30, 2016: Journal of Cellular Physiology
Catalina Coclitu, Cris S Constantinescu, Radu Tanasescu
INTRODUCTION: There are not many conditions in which the last few decades have brought such a major change in the landscape of treatments as is the case of multiple sclerosis (MS). A number of disease modifying treatments (DMTs) are presently available for the treatment of the inflammatory phase of this disabling disease; however, the need for treating neurodegeneration and halting the progression of disability is still unmet. AREAS COVERED: In this paper we review the available information on existing and emerging DMTs and we discuss their place within the context of different treatment strategies in MS, Expert Commentary: The future of MS treatments should include the development of new treatment strategies tackling disease progression, together with a better understanding of the side-effects and the best sequential strategy of implementation of available and emerging drugs...
September 29, 2016: Expert Review of Neurotherapeutics
Diana Rocío Higuera-Mendieta, Sebastián Cortés-Corrales, Juliana Quintero, Catalina González-Uribe
During the last few decades, several studies have analyzed and described knowledge, attitudes, and practices (KAP) of populations regarding dengue. However, few studies have applied geometric data analytic techniques to generate indices from KAP domains. Results of such analyses have not been used to determine the potential effects of sociodemographic variables on the levels of KAP. The objective was to determine the sociodemographic factors related to different levels of KAP regarding dengue in two hyper-endemic cities of Colombia, using a multiple correspondence analysis (MCA) technique...
September 2016: PLoS Neglected Tropical Diseases
Catalina Vargas, Patricio Torres, María Isabel Jercic, Marta Lobos, Alan Oyarce, Juan Carlos Miranda, Salvador Ayala
The frequency of anti-Toxocara spp. antibodies in individuals attended by the Centro de Salud Familiar in the coastal Niebla town, Chile, was related to the host and to environmental factors. IgG anti- Toxocara antibodies were detected with a commercial ELISA kit (SCIMEDX Corporation, USA). Samples with undetermined absorbance values were subjected to an additional ELISA standardized by the Instituto de Salud Pública, Chilean Health Ministry, a commercial ELISA (NOVATEC, Germany), and a commercial Western blot kit (LDBio Diagnostics, France)...
2016: Revista do Instituto de Medicina Tropical de São Paulo
W Porter McRoberts, Catalina Apostol, Abdul Haleem
UNLABELLED: Complex regional pain syndrome (CRPS) presents a therapeutic challenge due to its many presentations and multifaceted pathophysiology. There is no approved treatment algorithm and clinical interventions are often applied empirically. In cases of CRPS where symptoms are localized to an extremity, a targeted treatment is indicated. We describe the use of intrathecal bupivacaine monotherapy, delivered through a retrograde catheter, in the treatment of CRPS affecting the lower extremity...
September 2016: Pain Physician
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